cloransulam-methyl

Description

Cloransulam-methyl is a sulfonylurea herbicide used to control broadleaf weeds in a variety of crops, including corn, soybeans, and wheat. It is a highly effective herbicide, but its use has been linked to negative environmental impacts, including contamination of water sources. Cloransulam-methyl is synthesized through a multi-step process, starting with the reaction of 2-chloro-4-trifluoromethylbenzoic acid with N,N-dimethylformamide. The resulting product is then reacted with an amine, followed by a series of steps that result in the formation of cloransulam-methyl. Cloransulam-methyl works by inhibiting the enzyme acetolactate synthase (ALS), which is essential for the biosynthesis of branched-chain amino acids in plants. Inhibition of ALS results in the death of plants. The importance of studying cloransulam-methyl includes its use in agriculture to control weeds, understanding its environmental impact, and exploring alternative herbicides with reduced environmental risks. Research on cloransulam-methyl focuses on understanding its mechanism of action, its environmental fate and transport, and the development of methods to mitigate its negative impacts.'

cloransulam-methyl: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

cloransulam-methyl : The methyl ester of cloransulam. An inhibitor of acetohydroxyacid synthase (AHAS), it prevents the synthesis of amino acids in plants and is used as a herbicide for the control of post-emergence control of broad-leaved weeds in soybeans. It is not approved for use within the European Area. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]