Drug Refractory Epilepsy

Epileptic condition in which adequate trials of two tolerated and appropriately chosen and used ANTIEPILEPTIC DRUGS schedules to achieve sustained seizure freedom failed.

Synonym
Epilepsy, Drug Resistant
Epilepsy, Drug Refractory
Medication Resistant Epilepsy
Epilepsy, Intractable
Drug Refractory Epilepsy
Refractory Epilepsy
Drug Resistant Epilepsy
Intractable Epilepsy

Excerpt	Reference
"Patients with refractory epilepsy are resistance to antiepileptic drugs (AEDs)."	( Chen, Y; Hong, Z; Jiang, H; Wang, C; Xiao, X; Xu, G, 2015)
"Intractable epilepsy is a brain disorder characterized by recurrent seizures and intracellular alpha-synuclein (αS) deposits; however, the neurobiological basis of this protein accumulation is still poorly understood."	( Jin, L; Rong, H; Wang, X; Wei, W; Xi, Z, 2015)
"Refractory epilepsy is a type of epilepsy involving seizures uncontrolled by first or second- line anticonvulsant drugs at a regular therapeutic dose."	( Chawla, P; Gupta, GD; Langeh, U; Singh, S, 2020)

Excerpt	Reference
"People with drug-refractory epilepsy have increased risks of premature death, injuries, psychosocial dysfunction, and a reduced quality of life."	( Ji, H; Jia, Y; Liu, F; Liu, Y; Song, L; Zhang, R, 2018)

Excerpt	Reference
"Medical records of 50 children with refractory epilepsy treated with levetiracetam and regularly followed at Assaf Harofeh Medical Center were retrospectively reviewed."	( Berkovitch, M; Dagan, Z; Gandelman-Marton, R; Heyman, E; Kohn, E; Sheinberg, R; Youngster, I, 2015)
"A 12-year-old boy with intractable epilepsy had tonic and atonic seizures despite treatment with valproic acid (3000mg/day), levetiracetam (3000mg/day) and clobazam (40mg/day)."	( Aydın, A; Aydınlı, N; Bektaş, G; Çalışkan, M; Özmen, M; Pembegül Yıldız, E; Tatlı, B, 2016)
"Children with intractable epilepsy treated with prednisone or IVIg between 2005-2016 were reviewed retrospectively."	( Mailo, J; Rosenblatt, B; Tang-Wai, R, 2017)
"Patients with childhood-onset refractory epilepsy, treated at the tertiary epilepsy center of the University Children's Hospital Ljubljana, Slovenia, were included in the study."	( Neubauer, D; Osredkar, D; Perković Benedik, M, 2018)
"All participants with treatment-refractory epilepsy participating in our expanded access program (EAP) were approached for participation."	( Ampah, SB; Bebin, EM; Gaston, TE; Grayson, LE; Hernando, K; Moreadith, R; Szaflarski, JP, 2019)
"The difficulty to treat refractory epilepsy is because of drug resistance due to cellular drug efflux, use of drug monotherapy, and subtherapeutic dose administration."	( Chawla, P; Gupta, GD; Langeh, U; Singh, S, 2020)
"A total of 184 paediatric patients with refractory epilepsy received addon perampanel therapy, and of these, 128 received treatment for ≥nine months and underwent genetic analysis."	( Chen, X; Dai, Y; Li, Y; Qu, R; Qu, X; Shao, X; Zhou, R; Zhu, Y, 2022)
"Adults with refractory epilepsy who were treated with diazepam nasal spray for seizure clusters maintained or improved QOLIE subscale scores across the 12-month study period."	( Carrazana, E; Cramer, JA; Davis, C; Faught, E; Misra, SN; Rabinowicz, AL, 2022)
"Management of drug resistant epilepsy (DRE) represents a challenge to the treating clinician."	( Ben-Menachem, E; Kälviäinen, R; Lattanzi, S; Nashef, L; Schmitz, B; Vonck, K, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	384 (53.41)	28.8240
2020's	335 (46.59)	9.53

Drug	Relationship Strength	Studies	Trials
acetylcarnitine	low	1	0
gamma-aminobutyric acid	medium	14	1
aminolevulinic acid	low	1	0
bromide	low	4	0
carbamates	medium	12	1
carnitine	low	1	0
choline	low	3	0
citric acid, anhydrous	low	1	0
chlorine	low	1	0
salicylic acid	low	23	0
3-hydroxybutyric acid	low	4	0
methylmalonic acid	low	1	0
creatine	low	3	0
lactic acid	low	2	0
histamine	low	1	0
kynurenine	low	1	0
inositol	low	2	0
melatonin	low	1	0
pyridoxal phosphate	low	1	0
pyridoxine	low	2	0
selenic acid	medium	2	1
spermine	low	1	0
huperzine a	low	1	0
homovanillic acid	low	1	0
phenytoin	medium	21	3
hydroxyindoleacetic acid	low	1	0
ambroxol	low	1	0
amobarbital	low	3	0
baclofen	low	1	0
bumetanide	medium	4	1
caffeine	low	1	0
verapamil	medium	6	1
carbamazepine	medium	33	3
carbamazepine epoxide	medium	1	1
ciprofloxacin	low	1	0
clobazam	medium	22	2
clonazepam	low	3	0
clotrimazole	low	1	0
decanoic acid	low	1	0
diazepam	medium	12	1
diazoxide	low	2	0
valproic acid	medium	30	1
dsp 4	low	1	0
erythrosine	low	2	0
ethosuximide	low	1	0
felbamate	low	3	0
fenfluramine	medium	2	2
fenofibrate	low	1	0
fentanyl	low	1	0
flumazenil	low	2	0
fluoxetine	low	1	0
gabapentin	medium	8	1
isoflurane	low	2	0
isoniazid	low	1	0
ketamine	low	11	0
ketoconazole	low	1	0
khellin	low	1	0
kynurenic acid	low	1	0
lamotrigine	medium	30	2
lorazepam	low	2	0
losartan	low	1	0
metformin	low	1	0
metoclopramide	low	1	0
midazolam	medium	10	1
modafinil	low	1	0
muscimol	medium	1	1
apnea	low	4	0
nimodipine	low	1	0
pentobarbital	low	1	0
phenobarbital	low	10	0
piracetam	low	10	0
propofol	low	12	0
risperidone	low	1	0
ro 15-4513	low	1	0
sevoflurane	low	3	0
sulthiame	low	3	0
temozolomide	low	1	0
tranexamic acid	low	1	0
vigabatrin	medium	6	1
zonisamide	low	8	0
thyroxine	low	4	0
prednisone	low	2	0
pilocarpine	low	13	0
pentylenetetrazole	low	6	0
triiodothyronine	low	2	0
serine	low	3	0
aspartic acid	low	3	0
glutamine	low	1	0
2,3,4,6-tetrachlorophenol	low	4	0
uridine	low	2	0
barbituric acid	low	1	0
asparagine	low	1	0
tryptophan	low	1	0
isoleucine	low	1	0
3-mercaptopropionic acid	low	1	0
methylprednisolone	low	4	0
rotenone	low	1	0
pyrroles	low	1	0
isoxazoles	low	1	0
bicuculline	low	1	0
kainic acid	low	11	0
malondialdehyde	low	1	0
acetylcysteine	low	1	0
potassium citrate	medium	1	1
tetramethylpyrazine	low	1	0
s,n,n'-tripropylthiocarbamate	low	2	0
dronabinol	low	7	0
n-methylaspartate	low	2	0
titanium	low	1	0
gadolinium	low	1	0
gold	low	1	0
pregnanolone	low	3	0
8-bromo cyclic adenosine monophosphate	low	1	0
glutamic acid	medium	15	1
azides	low	1	0
oxcarbazepine	low	15	0
s-adenosylmethionine	low	1	0
etoposide	low	1	0
nimustine	low	1	0
fosphenytoin	low	2	0
tiagabine	low	3	0
remifentanil	low	2	0
adenosine	low	2	0
venlafaxine hydrochloride	low	1	0
n-acetylaspartic acid	low	3	0
triazoles	low	7	0
fluorodeoxyglucose f18	low	37	0
triheptanoin	medium	2	2
tetrandrine	low	1	0
n-desmethylclobazam	low	1	0
homocysteine	low	3	0
vitamin b 6	low	2	0
bicuculline methiodide	low	1	0
fingolimod hydrochloride	low	1	0
ezogabine	medium	4	1
methotrexate	low	2	0
rufinamide	low	7	0
proline	low	1	0
sdz wag-994	low	1	0
atropine	low	1	0
organophosphonates	low	1	0
eslicarbazepine acetate	medium	8	2
lacosamide	medium	36	1
potassium bromide	low	4	0
lithium chloride	low	1	0
quinidine	low	4	0
rocuronium	low	1	0
vinpocetine	low	1	0
arachidonic acid	low	1	0
tacrolimus	low	1	0
eicosapentaenoic acid	medium	2	1
kt 5720	low	1	0
cannabidiol	medium	106	18
etomidate	low	1	0
D-fructopyranose	medium	3	1
at 61	low	1	0
thiopental	low	5	0
lithium	low	2	0
thiamylal	low	1	0
cystine	low	1	0
freedom	low	15	0
sb 225002	low	1	0
myelin basic protein	low	1	0
sphingosine	low	1	0
bilirubin	low	1	0
cholecalciferol	low	1	0
alpha-linolenic acid	low	1	0
humulene	medium	19	2
sphingosine 1-phosphate	low	1	0
levetiracetam	medium	41	11
nabilone	low	1	0
sirolimus	medium	5	2
topiramate	medium	12	1
morphine	low	1	0
dexmedetomidine	low	3	0
stiripentol	medium	12	1
cysteine	low	2	0
pregabalin	medium	5	1
tetrodotoxin	low	1	0
selenium	low	2	0
everolimus	medium	8	2
ganaxolone	low	3	0
rwj-333369	low	1	0
sincalide	low	1	0
ucb 34714	medium	21	5
mocetinostat	low	1	0
perampanel	medium	63	10
alpha-synuclein	low	1	0
oxadiazoles	medium	1	1
ptc 124	medium	1	1
cannabidivarin	low	1	0
lorcaserin	low	1	0
losartan potassium	low	1	0
dextrothyroxine	low	3	0
cholecystokinin	low	1	0
neuropeptide y	low	2	0
adenosine kinase	low	1	0
gw 1000	low	1	0
piperidines	medium	2	1
selurampanel	low	1	0
vasoactive intestinal peptide	low	1	0
natriuretic peptide, brain	low	1	0
3-amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid	low	1	0
warfarin	low	1	0
sar127303	low	1	0
transforming growth factor beta	low	2	0
coriaria lactone	low	1	0
vitamin b 12	low	1	0
transforming growth factor alpha	low	1	0
cyclosporine	low	1	0
acyclovir	low	1	0
folic acid	low	1	0
clozapine	low	2	0
clozapine n-oxide	low	1	0
5-methyltetrahydrofolate	low	1	0
eye	low	1	0
technetium tc 99m bicisate	low	2	0
2',7'-bis-(2-carboxyethyl)-5(6)-carboxyfluorescein acetoxymethyl ester	low	1	0
leptin	low	4	0

Protein Targets (1,664)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, HADH2 protein	19	0	0	19
Chain B, HADH2 protein	19	0	0	19
Luciferase	16	0	0	16
interleukin 8	3	0	0	3
RAR-related orphan receptor gamma	24	0	0	24
GLI family zinc finger 3	32	0	0	32
AR protein	49	0	0	49
thyroid stimulating hormone receptor	27	0	0	27
estrogen receptor 2 (ER beta)	14	0	0	14
nuclear receptor subfamily 1, group I, member 3	28	0	0	28
progesterone receptor	21	0	0	21
glucocorticoid receptor [Homo sapiens]	36	0	0	36
retinoic acid nuclear receptor alpha variant 1	25	0	0	25
retinoid X nuclear receptor alpha	22	0	0	22
estrogen-related nuclear receptor alpha	36	0	0	36
farnesoid X nuclear receptor	19	0	0	19
pregnane X nuclear receptor	33	0	0	33
estrogen nuclear receptor alpha	55	0	0	55
peroxisome proliferator-activated receptor delta	14	0	0	14
peroxisome proliferator activated receptor gamma	25	0	0	25
aryl hydrocarbon receptor	17	0	0	17
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	26	0	0	26
Histone H2A.x	11	0	0	11
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	17	0	0	17
thyroid hormone receptor beta isoform 2	35	0	0	35
heat shock protein beta-1	9	0	0	9
mitogen-activated protein kinase 1	12	0	0	12
nuclear factor erythroid 2-related factor 2 isoform 1	26	0	0	26
Voltage-dependent calcium channel gamma-2 subunit	14	0	0	14
Cellular tumor antigen p53	33	0	0	33
Glutamate receptor 2	14	6	3	26
Nuclear receptor ROR-gamma	6	0	0	6
Peroxisome proliferator-activated receptor alpha	1	1	2	4
ATPase family AAA domain-containing protein 5	12	0	0	12
Ataxin-2	16	0	0	16
Protein skinhead-1	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
Solute carrier family 22 member 20	0	4	0	4
Solute carrier family 22 member 6	0	4	0	4
Stromelysin-1	0	1	2	3
Beta-lactamase	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	4	0	4
Chain A, JmjC domain-containing histone demethylation protein 3A	12	0	0	12
Chain A, 2-oxoglutarate Oxygenase	25	0	0	25
Chain A, ATP-DEPENDENT DNA HELICASE Q1	7	0	0	7
acetylcholinesterase	11	0	0	11
dopamine D1 receptor	3	0	0	3
15-lipoxygenase, partial	9	0	0	9
pregnane X receptor	3	0	0	3
phosphopantetheinyl transferase	26	0	0	26
USP1 protein, partial	28	0	0	28
NFKB1 protein, partial	8	0	0	8
Microtubule-associated protein tau	20	0	0	20
Thrombopoietin	3	0	0	3
regulator of G-protein signaling 4	23	0	0	23
vitamin D (1,25- dihydroxyvitamin D3) receptor	16	0	0	16
arylsulfatase A	27	0	0	27
euchromatic histone-lysine N-methyltransferase 2	64	0	0	64
Bloom syndrome protein isoform 1	33	0	0	33
D(1A) dopamine receptor	15	0	0	15
thyroid hormone receptor beta isoform a	17	0	0	17
flap endonuclease 1	11	0	0	11
geminin	51	0	0	51
peripheral myelin protein 22	21	0	0	21
survival motor neuron protein isoform d	17	0	0	17
muscarinic acetylcholine receptor M1	24	0	0	24
Histone deacetylase 3	0	6	0	6
Solute carrier family 22 member 6	0	3	0	4
Histone deacetylase 4	0	5	0	5
Guanine nucleotide-binding protein G	4	0	0	4
Histone deacetylase 1	0	6	0	6
Histone deacetylase 7	0	5	0	5
Histone deacetylase 2	0	6	0	6
Polyamine deacetylase HDAC10	0	4	0	4
Histone deacetylase 11	0	5	0	5
Histone deacetylase 8	0	5	0	5
Histone deacetylase 6	0	5	0	5
Histone deacetylase 9	0	4	0	4
Histone deacetylase 5	0	5	0	5
ATP-dependent phosphofructokinase	27	0	0	27
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, Ferritin light chain	20	0	0	20
Thymidine kinase	0	1	0	1
thioredoxin reductase	41	0	0	41
GLS protein	28	0	0	28
TDP1 protein	48	0	0	48
Smad3	9	0	0	9
EWS/FLI fusion protein	30	0	0	30
activating transcription factor 6	10	0	0	10
hemoglobin subunit beta	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	5	0	0	5
ubiquitin carboxyl-terminal hydrolase 2 isoform a	7	0	0	7
lamin isoform A-delta10	47	0	0	47
Solute carrier family 22 member 1	0	13	0	17
ATP-binding cassette sub-family C member 3	0	41	0	41
Multidrug resistance-associated protein 4	0	41	0	43
Bile salt export pump	0	12	0	12
Bile salt export pump	0	62	0	62
Purine nucleoside phosphorylase	0	2	0	2
Thymidine kinase, cytosolic	0	0	0	1
POU domain, class 2, transcription factor 2	0	0	0	1
Cytochrome P450 2C9	0	16	1	18
Cytochrome P450 2J2	0	6	0	7
Disintegrin and metalloproteinase domain-containing protein 17	5	0	0	5
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	1	0	3
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	3
Canalicular multispecific organic anion transporter 1	0	39	0	40
Thymidine kinase	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	29	0	0	29
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
NPYLR7B	0	0	1	1
IDH1	11	0	0	11
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
nuclear receptor ROR-gamma isoform 1	23	0	0	23
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	4	0	4
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Sodium/nucleoside cotransporter 2	0	4	0	4
Rap guanine nucleotide exchange factor 3	6	0	0	6
Epidermal growth factor receptor	0	2	2	4
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Insulin receptor	0	0	2	3
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	1	1	2
Platelet-derived growth factor receptor beta	0	0	2	3
Adenosine receptor A3	0	8	2	11
Heat shock 70 kDa protein 1A	0	1	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
Fibroblast growth factor receptor 1	0	0	2	3
Inosine-5'-monophosphate dehydrogenase 2	0	1	2	3
Endoplasmin	0	1	1	2
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	0	0	1
Adenosine receptor A1	0	5	1	8
Adenosine receptor A3	0	2	0	2
Adenosine receptor A2a	0	5	3	10
Adenosine receptor A2b	0	1	1	4
Adenosine receptor A2b	0	3	1	5
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	7	3	13
Adenosine receptor A2a	0	5	1	9
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	2	0	3
Adenosine receptor A1	0	1	1	2
Adenosine kinase	0	0	2	3
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	4	0	4
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	3
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	4	0	4
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	3
Solute carrier family 28 member 3	0	4	0	4
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	2	0	3
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	18	0	0	18
Chain A, Beta-lactamase	13	0	0	13
Chain A, Cruzipain	10	0	0	10
WRN	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	8	0	0	8
SMAD family member 2	8	0	0	8
SMAD family member 3	8	0	0	8
thioredoxin glutathione reductase	8	0	0	8
aldehyde dehydrogenase 1 family, member A1	36	0	0	36
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	11	0	0	11
v-jun sarcoma virus 17 oncogene homolog (avian)	13	0	0	13
Caspase-7	3	0	0	3
phospholipase A2 precursor	0	1	0	1
vitamin D3 receptor isoform VDRA	14	0	0	14
caspase-3	3	0	0	3
importin subunit beta-1 isoform 1	7	0	0	7
serine/threonine-protein kinase PLK1	3	0	0	3
snurportin-1	7	0	0	7
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	7	0	0	7
DNA polymerase eta isoform 1	4	0	0	4
DNA polymerase iota isoform a (long)	15	0	0	15
cysteine protease ATG4B isoform a	0	1	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	4	0	0	4
DNA polymerase kappa isoform 1	18	0	0	18
cytochrome P450 3A4 isoform 1	21	0	0	21
histone acetyltransferase KAT2A isoform 1	18	0	0	18
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	3	0	0	3
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	21	17	3	41
Free fatty acid receptor 1	0	0	1	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	6	0	0	6
Prostaglandin G/H synthase 1	0	3	0	4
Nuclear receptor subfamily 1 group I member 2	0	0	8	8
Trypsin	0	3	0	3
Coagulation factor VII	0	4	0	4
Aromatase	0	7	0	7
Tissue factor	0	5	0	5
Gamma-aminobutyric acid receptor subunit beta-1	21	17	3	41
Gamma-aminobutyric acid receptor subunit delta	21	17	3	41
Gamma-aminobutyric acid receptor subunit gamma-2	21	17	5	43
Gamma-aminobutyric acid receptor subunit alpha-5	21	17	3	41
Gamma-aminobutyric acid receptor subunit alpha-3	21	17	3	41
Prostaglandin G/H synthase 1	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	21	17	3	41
Gamma-aminobutyric acid receptor subunit alpha-2	21	17	3	41
Gamma-aminobutyric acid receptor subunit alpha-4	21	17	3	41
Gamma-aminobutyric acid receptor subunit gamma-3	21	17	3	41
Gamma-aminobutyric acid receptor subunit alpha-6	21	17	3	41
Peroxisome proliferator-activated receptor gamma	0	2	9	11
Histamine H2 receptor	13	0	1	15
Gamma-aminobutyric acid receptor subunit alpha-1	21	17	5	43
Gamma-aminobutyric acid receptor subunit beta-3	21	17	3	41
Gamma-aminobutyric acid receptor subunit beta-2	21	17	5	43
Prostaglandin G/H synthase 2	0	2	0	3
Free fatty acid receptor 4	0	0	1	1
GABA theta subunit	21	17	3	41
Gamma-aminobutyric acid receptor subunit epsilon	21	17	3	41
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	8	0	0	8
cytochrome P450 2D6	23	0	0	23
glucocerebrosidase	7	0	0	7
cytochrome P450 2D6 isoform 1	14	0	0	14
chromobox protein homolog 1	30	0	0	30
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
Lysosomal acid glucosylceramidase	0	1	0	1
Cytochrome P450 2D6	0	15	0	17
Sodium-dependent serotonin transporter	0	17	3	20
TAR DNA-binding protein 43	8	0	0	8
bromodomain adjacent to zinc finger domain 2B	14	0	0	14
Gamma-aminobutyric acid receptor subunit rho-1	0	1	4	5
Glutamate receptor 1	0	5	2	7
Glutamate receptor 2	0	4	2	6
Glutamate receptor 3	0	2	2	4
Glutamate receptor ionotropic, kainate 3	0	7	0	8
Solute carrier family 15 member 1	0	1	0	1
Glutamate receptor 4	0	4	1	5
Solute carrier family 15 member 1	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
ATAD5 protein, partial	19	0	0	19
neuropeptide S receptor isoform A	12	0	0	12
Chain A, ADIPOCYTE LIPID-BINDING PROTEIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
cellular tumor antigen p53 isoform a	6	0	0	6
caspase-1 isoform alpha precursor	3	0	0	3
Fatty-acid amide hydrolase 1	0	3	0	3
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	2	0	2
Fatty acid-binding protein, adipocyte	0	1	1	2
Prostaglandin G/H synthase 2	0	2	1	4
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
10 kDa heat shock protein, mitochondrial	0	2	0	2
Calmodulin	0	0	1	2
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Fatty acid-binding protein 5	0	1	0	1
Fatty acid-binding protein 5	0	0	1	1
Thiosulfate sulfurtransferase	0	2	0	2
Lanosterol 14-alpha demethylase	0	4	1	5
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
Solute carrier organic anion transporter family member 1B3	0	8	0	12
Cytosolic phospholipase A2 gamma	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	2	1	3
Solute carrier organic anion transporter family member 1B1	0	10	0	13
Carbonic anhydrase 1	0	19	0	29
Carbonic anhydrase 2	0	20	3	34
Neutral amino acid transporter A	0	4	0	4
Neutral amino acid transporter B(0)	0	4	0	4
Carbonic anhydrase-like protein, putative	0	0	0	6
Amino acid transporter	0	4	0	4
cytochrome P450 2C19 precursor	15	0	0	15
lethal factor (plasmid)	9	0	0	9
Metabotropic glutamate receptor 6	0	1	3	5
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	13	4	22
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Glutamate receptor ionotropic, NMDA 2A	0	11	3	19
Glutamate receptor ionotropic, NMDA 2B	0	12	4	21
Glutamate receptor ionotropic, NMDA 2C	0	11	3	19
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Glutamate receptor ionotropic, NMDA 2D	0	11	3	19
Glutamate receptor ionotropic, NMDA 3B	0	11	3	19
Carbonic anhydrase 4	0	2	0	4
Glutamate receptor ionotropic, NMDA 3A	0	11	3	19
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	8	0	0	8
short transient receptor potential channel 6 isoform 1	0	0	2	2
5-hydroxytryptamine receptor 4	0	18	1	19
Muscarinic acetylcholine receptor M2	0	10	3	16
Muscarinic acetylcholine receptor M4	0	7	2	11
Muscarinic acetylcholine receptor M1	0	8	2	13
Muscarinic acetylcholine receptor M3	0	8	2	13
Muscarinic acetylcholine receptor M4	0	8	2	13
Muscarinic acetylcholine receptor M5	0	8	2	13
Muscarinic acetylcholine receptor M5	0	8	1	11
Muscarinic acetylcholine receptor M2	0	8	2	14
Muscarinic acetylcholine receptor M1	0	10	4	17
Muscarinic acetylcholine receptor M1	0	0	1	2
Muscarinic acetylcholine receptor M3	0	10	2	14
Alpha-1D adrenergic receptor	0	9	0	9
5-hydroxytryptamine receptor 2C	0	20	2	22
Muscarinic acetylcholine receptor M4	0	1	0	1
5-hydroxytryptamine receptor 7	0	5	0	5
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	2	1	4
Carbonic anhydrase 4	0	12	0	18
Carbonic anhydrase	0	4	0	6
Carbonic anhydrase 15	0	9	0	11
67.9K protein	6	0	0	6
Gamma-aminobutyric acid type B receptor subunit 2	0	3	2	5
Gamma-aminobutyric acid type B receptor subunit 2	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	3	2	5
Gamma-aminobutyric acid type B receptor subunit 1	0	2	0	2
Polyphenol oxidase 2	0	3	0	4
Gamma-aminobutyric acid receptor subunit pi	0	13	0	13
Gamma-aminobutyric acid receptor subunit delta	0	13	0	13
Gamma-aminobutyric acid receptor subunit alpha-1	0	18	11	29
Gamma-aminobutyric acid receptor subunit beta-1	0	14	4	18
Gamma-aminobutyric acid receptor subunit gamma-2	0	16	9	25
Gamma-aminobutyric acid receptor subunit beta-3	0	17	6	23
Gamma-aminobutyric acid receptor subunit alpha-5	0	15	8	23
Gamma-aminobutyric acid receptor subunit alpha-3	0	15	6	21
Gamma-aminobutyric acid receptor subunit alpha-2	0	15	7	22
Gamma-aminobutyric acid receptor subunit beta-2	0	16	8	24
Gamma-aminobutyric acid receptor subunit alpha-4	0	15	4	19
Gamma-aminobutyric acid receptor subunit epsilon	0	13	0	13
Gamma-aminobutyric acid receptor subunit alpha-6	0	15	4	19
Gamma-aminobutyric acid receptor subunit gamma-1	0	13	0	13
Gamma-aminobutyric acid receptor subunit gamma-3	0	13	0	13
Gamma-aminobutyric acid receptor subunit theta	0	13	0	13
acid sphingomyelinase	4	0	0	4
hypothetical protein, conserved	3	0	0	3
lysosomal alpha-glucosidase preproprotein	5	0	0	5
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	4	0	5
Neuronal acetylcholine receptor subunit beta-2	1	4	0	5
Chain A, Putative fructose-1,6-bisphosphate aldolase	7	0	0	7
Caspase-7	2	0	0	2
Inositol monophosphatase 1	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 2	14	0	0	14
muscleblind-like protein 1 isoform 1	6	0	0	6
Carbonic anhydrase 12	0	9	0	15
Carbonic anhydrase 3	0	8	0	10
Carbonic anhydrase 6	0	8	0	14
Carbonic anhydrase 5A, mitochondrial	0	10	2	18
Carbonic anhydrase 7	0	8	0	14
Solute carrier family 12 member 2	0	1	0	1
Carbonic anhydrase 9	0	10	0	16
Carbonic anhydrase 13	0	4	0	10
Carbonic anhydrase 14	0	8	0	14
Carbonic anhydrase 5B, mitochondrial	0	8	0	14
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
thyroid stimulating hormone receptor	11	0	0	11
Potassium channel subfamily K member 2	0	1	1	2
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	1	0	1
Cholinesterase	0	5	0	5
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Replicase polyprotein 1ab	0	3	0	3
Amine oxidase [flavin-containing] A	0	2	0	2
Acetylcholinesterase	0	10	0	10
Amine oxidase [flavin-containing] B	0	4	0	4
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	4	2	6
Adenosine receptor A2a	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	2	2	4
Endochitinase B1	0	1	0	1
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	7	1	9
Guanine deaminase	0	1	0	1
PPM1D protein	6	0	0	6
Acetylcholinesterase	0	4	0	4
L-lactate dehydrogenase A chain	0	2	0	2
Interferon beta	26	0	0	26
Cytochrome P450 1A1	0	6	0	6
Cytochrome P450 1A2	0	7	1	8
Cytochrome P450 2C11	0	3	0	3
Cytochrome P450 3A4	0	19	2	24
5-hydroxytryptamine receptor 1A	0	3	3	6
Cytochrome P450 2A6	0	4	1	5
Steroid 17-alpha-hydroxylase/17,20 lyase	0	2	0	2
Fatty acid-binding protein, liver	0	2	0	2
5-hydroxytryptamine receptor 2A	0	9	2	11
Alpha-2B adrenergic receptor	0	11	0	11
Alpha-2C adrenergic receptor	0	6	1	7
Cannabinoid receptor 1	0	5	1	6
Cytochrome P450 2B6	0	3	1	4
Cytochrome P450 3A5	0	2	0	2
Cannabinoid receptor 1	0	7	2	11
D(1A) dopamine receptor	0	7	0	8
Cytochrome P450 3A7	0	1	0	1
Caspase-1	0	0	1	1
Cytochrome P450 2C19	0	14	0	15
Cannabinoid receptor 2	0	5	3	10
Mu-type opioid receptor	0	9	4	16
Delta-type opioid receptor	0	11	4	18
Kappa-type opioid receptor	0	9	2	15
Spike glycoprotein	19	0	0	19
Cholinesterase	0	5	0	5
N-acylethanolamine-hydrolyzing acid amidase	0	2	0	2
Cytochrome P450 1B1	0	4	0	4
Heat sensitive channel TRPV3	0	1	1	2
Sigma intracellular receptor 2	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	1	3	4
Transient receptor potential cation channel subfamily V member 1	0	2	2	4
Transient receptor potential cation channel subfamily M member 8	0	2	0	2
Transient receptor potential cation channel subfamily V member 4	0	1	1	2
G-protein coupled receptor 55	0	1	3	4
Diacylglycerol lipase-alpha	0	2	0	2
Histamine H3 receptor	0	8	2	11
Transient receptor potential cation channel subfamily A member 1	0	1	1	3
G-protein coupled receptor 6	0	0	1	1
Transient receptor potential cation channel subfamily M member 8	0	1	0	1
Transient receptor potential cation channel subfamily V member 3	0	1	1	2
Transient receptor potential cation channel subfamily V member 4	0	1	1	2
Transient receptor potential cation channel subfamily V member 2	0	1	1	2
Vpr	1	0	0	1
Albumin	0	0	7	7
Major prion protein	0	0	1	1
Sodium channel protein type 1 subunit alpha	0	3	0	3
Sodium channel protein type 2 subunit alpha	0	4	1	5
Sodium channel protein type 3 subunit alpha	0	3	0	3
UDP-glucuronosyltransferase 2B7	0	3	1	7
Sodium channel protein type 4 subunit alpha	0	4	0	7
Potassium voltage-gated channel subfamily H member 2	0	25	0	26
Sodium channel protein type 9 subunit alpha	0	6	0	6
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	4	0	4
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Vitamin D3 receptor	0	1	1	4
Glycine receptor subunit alpha-1	0	0	3	3
Vitamin D3 receptor	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	2	0	4
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	5	0	5
Solute carrier family 22 member 1	0	4	0	8
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	4	0	6
cytochrome P450 2C9 precursor	9	0	0	9
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	2	0	4
DNA gyrase subunit B	0	2	0	4
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
DNA topoisomerase 2-alpha	0	3	3	14
DNA gyrase subunit A	0	1	0	2
Multidrug resistance protein MdtK	0	0	1	1
DNA gyrase subunit B	0	2	0	2
DNA gyrase subunit A	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	3
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Beta-lactamase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	2	3
3-dehydroquinate dehydratase	0	0	1	1
ATP-citrate synthase	0	1	0	2
Ribonuclease T	0	0	0	1
Cell death-related nuclease 4	0	0	0	1
3-dehydroquinate dehydratase	0	0	1	1
Prolyl 4-hydroxylase	0	2	0	2
Alpha-ketoglutarate-dependent dioxygenase FTO	0	2	0	2
nuclear receptor subfamily 1, group I, member 2	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	0	5	0	8
Gamma-aminobutyric acid receptor subunit beta-1	0	5	0	8
Gamma-aminobutyric acid receptor subunit alpha-2	0	5	0	8
Gamma-aminobutyric acid receptor subunit alpha-3	0	5	0	8
Gamma-aminobutyric acid receptor subunit alpha-4	0	5	0	8
Gamma-aminobutyric acid receptor subunit gamma-2	0	5	0	8
Translocator protein	0	2	0	2
Translocator protein	0	3	0	3
Cholecystokinin receptor type A	1	4	0	5
Gastrin/cholecystokinin type B receptor	1	3	1	5
endonuclease IV	10	0	0	10
glp-1 receptor, partial	12	0	0	12
Fumarate hydratase	8	0	0	8
isocitrate dehydrogenase 1, partial	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	31	0	0	31
nonstructural protein 1	8	0	0	8
G	23	0	0	23
polyprotein	8	0	0	8
alpha-galactosidase	7	0	0	7
pyruvate kinase	1	0	0	1
heat shock protein 90	0	0	1	1
calcineurin A1, putative	0	0	1	1
thyrotropin-releasing hormone receptor	2	0	0	2
beta-2 adrenergic receptor	1	0	1	2
peripheral myelin protein 22 isoform 1	15	0	0	15
potassium voltage-gated channel subfamily H member 2 isoform d	22	0	0	22
huntingtin isoform 2	3	0	0	3
ras-related protein Rab-9A	4	0	0	4
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
M-phase phosphoprotein 8	13	0	0	13
streptokinase A precursor	0	0	2	2
Intermediate conductance calcium-activated potassium channel protein 4	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	5
Transient receptor potential cation channel subfamily M member 2	0	1	0	1
Chymotrypsinogen A	0	2	0	2
Beta-lactamase	0	2	0	2
HLA class I histocompatibility antigen, B alpha chain	23	0	0	23
Glucocorticoid receptor	0	6	1	7
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	2	0	2
Steroid 17-alpha-hydroxylase/17,20 lyase	0	3	0	3
Integrin beta-3	3	0	1	4
Histidine-rich protein PFHRP-II	0	2	0	2
Estrogen receptor	0	0	2	2
Tyrosine-protein kinase Fyn	0	1	2	3
Heme oxygenase 1	0	1	0	1
ATP-dependent translocase ABCB1	0	9	0	9
Epoxide hydrolase 1	0	0	0	2
Glycine receptor subunit alpha-1	0	6	0	6
Aldo-keto reductase family 1 member B1	0	13	0	13
ATP-dependent translocase ABCB1	0	15	1	29
Integrin alpha-IIb	3	0	1	4
Beta-1 adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	14	2	16
Beta-3 adrenergic receptor	0	4	0	4
D(2) dopamine receptor	0	10	0	13
Androgen receptor	0	4	0	4
Alpha-1B adrenergic receptor	0	11	1	12
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
5-hydroxytryptamine receptor 1A	0	15	1	16
Glycine receptor subunit beta	0	6	0	6
ATP-dependent translocase ABCB1	0	9	0	10
Substance-K receptor	0	4	0	4
D(4) dopamine receptor	0	7	0	9
Potassium voltage-gated channel subfamily A member 3	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Glycine receptor subunit alpha-2	0	6	0	6
Heme oxygenase 2	0	1	0	1
Sodium-dependent noradrenaline transporter	0	17	1	18
Glycine receptor subunit alpha-3	0	6	0	6
Thromboxane-A synthase	0	2	0	2
Histamine H2 receptor	0	11	2	13
C-X-C chemokine receptor type 1	0	2	0	2
Substance-P receptor	0	2	0	2
Platelet-activating factor receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	15	1	18
5-hydroxytryptamine receptor 1B	0	9	0	9
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Vasopressin V2 receptor	0	1	0	1
Histamine H1 receptor	0	10	4	16
D(3) dopamine receptor	0	14	1	17
Alpha-synuclein	4	0	0	4
Malate dehydrogenase, cytoplasmic	0	2	0	2
5-hydroxytryptamine receptor 2B	0	13	2	15
Alpha-1A adrenergic receptor	0	12	1	13
5-hydroxytryptamine receptor 6	0	9	0	10
C-C chemokine receptor type 4	0	1	0	1
Transitional endoplasmic reticulum ATPase	0	1	0	1
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Cytochrome P450 130	0	0	1	1
Cytochrome P450 130	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Sodium-dependent dopamine transporter	0	13	1	14
Voltage-dependent L-type calcium channel subunit alpha-1C	0	11	0	11
Nuclear receptor subfamily 1 group I member 3	0	2	0	2
Sterol 14-alpha demethylase	0	0	1	1
Estrogen receptor beta	0	0	2	2
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Rap guanine nucleotide exchange factor 4	3	0	0	3
Inositol hexakisphosphate kinase 1	23	0	0	23
Bile acid receptor	0	3	0	3
14-alpha sterol demethylase	0	0	1	1
Cysteinyl leukotriene receptor 1	0	2	0	2
cytochrome P450 2C9, partial	23	0	0	23
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
heat shock protein 90, putative	0	0	0	1
5-hydroxytryptamine receptor 3E	0	2	1	3
caspase 7, apoptosis-related cysteine protease	5	0	0	5
Beta-1 adrenergic receptor	0	1	0	1
caspase-3	5	0	0	5
Adenylate cyclase type 1	0	1	0	1
atrial natriuretic peptide receptor 2 precursor	3	0	0	3
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	8	0	8
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 3B	0	2	1	3
5-hydroxytryptamine receptor 2C	0	8	0	9
Calmodulin-1	0	1	0	1
Beta-2 adrenergic receptor	0	2	0	2
Angiotensin-converting enzyme	0	6	0	6
Beta-1 adrenergic receptor	0	2	0	2
D	0	4	0	4
D(3) dopamine receptor	0	4	0	4
Alpha-2B adrenergic receptor	0	6	1	7
D(2) dopamine receptor	0	3	0	3
Endothelin receptor type B	0	1	0	1
D(1B) dopamine receptor	0	1	0	2
Adenylate cyclase type 3	0	1	0	1
Alpha-2C adrenergic receptor	0	6	1	7
UDP-glucuronosyltransferase 1A4	0	2	1	6
Alpha-2A adrenergic receptor	0	6	1	7
Alpha-1D adrenergic receptor	0	7	1	8
Sodium-dependent dopamine transporter	0	8	1	9
5-hydroxytryptamine receptor 3A	0	2	0	2
Endothelin receptor type B	0	1	0	1
D(1B) dopamine receptor	0	3	0	3
Beta-3 adrenergic receptor	0	1	0	1
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
5-hydroxytryptamine receptor 1D	0	3	0	3
D(4) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 1F	0	3	0	3
5-hydroxytryptamine receptor 2B	0	7	1	8
Histamine H1 receptor	0	3	2	5
Histamine H1 receptor	0	4	1	5
Sodium-dependent serotonin transporter	0	6	1	7
5-hydroxytryptamine receptor 7	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
5-hydroxytryptamine receptor 7	0	2	0	2
Alpha-1A adrenergic receptor	0	3	0	3
5-hydroxytryptamine receptor 2A	0	2	0	2
Alpha-1B adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 3A	0	3	0	3
Adenylate cyclase type 8	0	1	0	1
5-hydroxytryptamine receptor 3A	0	2	1	3
5-hydroxytryptamine receptor 5A	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	3	0	3
D(2) dopamine receptor	0	2	0	2
D(2) dopamine receptor	0	10	0	10
Voltage-dependent L-type calcium channel subunit alpha-1D	0	8	0	8
5-hydroxytryptamine receptor 2B	0	2	0	2
Adenylate cyclase type 6	0	1	0	1
Adenylate cyclase type 5	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	8	0	8
Transporter	0	4	0	4
Cholecystokinin receptor type A	0	3	0	3
5-hydroxytryptamine receptor 1A	0	3	0	3
Nuclear receptor subfamily 3 group C member 3	0	6	0	6
5-hydroxytryptamine receptor 3D	0	2	1	3
Adenylyl cyclase 7	0	1	0	1
5-hydroxytryptamine receptor 3C	0	2	1	3
D	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	6	0	6
Histamine H4 receptor	0	3	3	6
5-hydroxytryptamine receptor 3B	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	4	1	5
Transporter	0	6	0	6
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	5	0	5
G-protein coupled receptor 84	0	1	1	2
Alpha-1B adrenergic receptor	0	0	1	1
Alpha-1A adrenergic receptor	0	0	1	1
Gamma-aminobutyric acid	0	2	2	4
Fatty acid-binding protein, liver	0	3	1	4
Alpha-1-acid glycoprotein 1	0	0	0	1
Albumin	0	1	3	5
Translocator protein	0	4	2	7
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	2	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	2	4
Gamma-aminobutyric acid receptor subunit delta	0	2	2	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	2	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	2	4
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	2	4
Gamma-aminobutyric acid receptor subunit beta-1	0	2	2	4
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	2	5
Gamma-aminobutyric acid receptor subunit beta-3	0	2	2	4
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	2	4
Gamma-aminobutyric acid receptor subunit pi	0	2	2	4
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	2	4
Gamma-aminobutyric acid receptor subunit theta	0	2	2	4
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	2	4
GTP-binding nuclear protein Ran isoform 1	3	0	0	3
Glutamate receptor 1	0	6	3	12
Glutamate receptor 3	0	6	3	12
Glutamate receptor 4	0	6	3	12
Nicotinamide phosphoribosyltransferase	0	0	1	1
ATP-binding cassette sub-family C member 8	0	1	1	2
ATP-sensitive inward rectifier potassium channel 11	0	1	1	2
Cannabinoid receptor 1	0	1	0	1
Cannabinoid receptor 2	0	1	1	2
N-arachidonyl glycine receptor	0	0	1	1
Lysophosphatidylserine lipase ABHD12	0	1	0	1
Monoglyceride lipase	0	2	0	2
Monoacylglycerol lipase ABHD6	0	1	0	1
Cannabinoid receptor 2	0	2	0	2
Chain A, Protein (peroxisome Proliferator Activated Receptor (ppar-delta))	0	1	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	6	0	0	6
Retinoic acid receptor RXR-alpha	0	1	2	3
Oxoeicosanoid receptor 1	0	1	0	1
Genome polyprotein	0	1	1	2
chaperonin-containing TCP-1 beta subunit homolog	3	0	0	3
eyes absent homolog 2 isoform a	1	0	0	1
relaxin receptor 1 isoform 1	1	0	0	1
Flavin reductase (NADPH)	0	0	2	2
large T antigen	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1I	0	2	0	2
Acetylcholine receptor subunit alpha	0	1	0	1
Acetylcholine receptor subunit beta	0	1	0	1
Acetylcholine receptor subunit gamma	0	1	0	1
Acetylcholine receptor subunit delta	0	1	0	1
Acetylcholine receptor subunit delta	0	1	0	1
Acetylcholine receptor subunit alpha	0	1	0	1
Acetylcholine receptor subunit gamma	0	1	0	1
Acetylcholine receptor subunit beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Cytochrome P450 11B2, mitochondrial	0	2	0	2
LMP1 [Human herpesvirus 4]	0	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	2	0	2
transactivating tegument protein VP16 [Human herpesvirus 1]	0	2	0	2
nuclear receptor coactivator 3 isoform a	0	2	0	2
Prothrombin	0	0	2	3
Regulatory protein E2	0	0	1	1
DNA topoisomerase 1	0	1	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
DNA topoisomerase 2	0	0	0	1
UDP-glucuronosyltransferase 1A1	0	4	1	8
Serum paraoxonase/arylesterase 1	0	1	0	1
Caspase-3	0	1	0	1
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	3	10
Tubulin beta-2B chain	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Bone morphogenetic protein receptor type-1B	0	0	2	2
Cell division cycle 7-related protein kinase	0	0	2	2
Serine/threonine-protein kinase PLK4	0	0	2	2
ATP-dependent RNA helicase DDX3X	0	0	2	2
Pyridoxal kinase	0	0	2	3
Citron Rho-interacting kinase	0	0	2	2
Serine/threonine-protein kinase Chk1	0	0	2	2
Aurora kinase A	0	0	2	2
Cyclin-G-associated kinase	0	0	2	2
Ephrin type-B receptor 6	0	0	2	2
Peroxisomal acyl-coenzyme A oxidase 3	0	0	2	2
Receptor-interacting serine/threonine-protein kinase 2	0	0	2	2
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	2	2
Dynamin-like 120 kDa protein, mitochondrial	0	0	2	2
Eukaryotic translation initiation factor 5B	0	0	2	2
Rho-associated protein kinase 2	0	0	2	2
Serine/threonine-protein kinase ULK1	0	0	2	2
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	2	2
Ribosomal protein S6 kinase alpha-5	0	0	2	2
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	2	2
Ribosomal protein S6 kinase alpha-4	0	0	2	2
Serine/threonine-protein kinase 16	0	0	2	2
Serine/threonine-protein kinase 10	0	0	2	2
Serine/threonine-protein kinase D3	0	0	2	2
Structural maintenance of chromosomes protein 2	0	0	2	2
Mitogen-activated protein kinase kinase kinase 6	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	2	2
Serine/threonine-protein kinase LATS1	0	0	2	2
Serine/threonine-protein kinase PAK 4	0	0	2	2
Tyrosine-protein kinase ABL1	0	1	3	4
High affinity nerve growth factor receptor	0	0	2	2
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	1	1
ADP/ATP translocase 2	0	0	2	2
Protein kinase C beta type	0	0	2	2
Tyrosine-protein kinase Lck	0	0	2	2
Cyclin-dependent kinase 1	0	0	2	2
Glycogen phosphorylase, liver form	0	0	2	2
Tyrosine-protein kinase Fes/Fps	0	0	2	2
Adenine phosphoribosyltransferase	0	0	2	2
Tyrosine-protein kinase Yes	0	0	2	2
Tyrosine-protein kinase Lyn	0	0	2	2
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	2	2
Insulin-like growth factor 1 receptor	0	0	2	2
Signal recognition particle receptor subunit alpha	0	0	2	2
Cytochrome c1, heme protein, mitochondrial	0	0	2	2
Hepatocyte growth factor receptor	0	0	2	2
Tyrosine-protein kinase HCK	0	0	2	2
Tyrosine-protein kinase Fgr	0	0	2	2
Serine/threonine-protein kinase A-Raf	0	0	2	2
Glycogen phosphorylase, brain form	0	0	2	2
Breakpoint cluster region protein	0	0	2	2
Serine/threonine-protein kinase pim-1	0	0	2	2
Cyclin-dependent kinase 4	0	0	2	2
ADP/ATP translocase 3	0	0	2	2
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	2	2
Serine/threonine-protein kinase B-raf	0	0	2	2
Potassium voltage-gated channel subfamily E member 1	0	3	0	3
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	2	2
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	2	4
Tyrosine-protein kinase Fer	0	0	2	2
Protein kinase C alpha type	0	0	2	2
cAMP-dependent protein kinase catalytic subunit alpha	0	0	2	2
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	2	2
Casein kinase II subunit alpha'	0	0	2	2
Ras-related protein Rab-6A	0	0	2	2
Ephrin type-A receptor 1	0	0	2	2
Multifunctional protein ADE2	0	0	2	2
cAMP-dependent protein kinase catalytic subunit gamma	0	0	1	1
cAMP-dependent protein kinase catalytic subunit beta	0	0	2	2
Ferrochelatase, mitochondrial	0	0	2	2
Ribosomal protein S6 kinase beta-1	0	0	2	2
Tyrosine-protein kinase JAK1	0	0	2	2
Cyclin-dependent kinase 2	0	0	3	3
Beta-adrenergic receptor kinase 1	0	0	2	2
Probable ATP-dependent RNA helicase DDX6	0	0	2	2
Mitogen-activated protein kinase 3	0	0	2	2
MAP/microtubule affinity-regulating kinase 3	0	0	2	2
Deoxycytidine kinase	0	0	2	2
Mitogen-activated protein kinase 1	0	0	2	2
Ephrin type-A receptor 2	0	0	2	2
Ephrin type-B receptor 2	0	0	2	2
Non-receptor tyrosine-protein kinase TYK2	0	0	2	2
UMP-CMP kinase	0	0	2	2
Phosphatidylethanolamine-binding protein 1	0	0	2	2
Wee1-like protein kinase	0	0	2	2
Heme oxygenase 2	0	0	2	2
S-adenosylmethionine synthase isoform type-2	0	0	2	2
DnaJ homolog subfamily A member 1	0	0	2	2
RAC-alpha serine/threonine-protein kinase	0	0	2	2
RAC-beta serine/threonine-protein kinase	0	0	2	2
Dual specificity protein kinase TTK	0	0	2	2
DNA replication licensing factor MCM4	0	0	2	2
Myosin-10	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 2	0	0	2	2
Receptor-type tyrosine-protein kinase FLT3	0	0	2	2
Bone morphogenetic protein receptor type-1A	0	0	2	2
Activin receptor type-1B	0	0	2	2
TGF-beta receptor type-1	0	0	2	2
TGF-beta receptor type-2	0	0	2	2
Electron transfer flavoprotein subunit beta	0	0	2	2
Tyrosine-protein kinase CSK	0	0	2	2
Glycine--tRNA ligase	0	0	2	2
Protein kinase C iota type	0	0	2	2
Exosome RNA helicase MTR4	0	0	2	2
Tyrosine-protein kinase Tec	0	0	2	2
Tyrosine-protein kinase ABL2	0	1	2	3
Tyrosine-protein kinase FRK	0	0	2	2
G protein-coupled receptor kinase 6	0	0	2	2
Tyrosine-protein kinase SYK	0	0	2	2
26S proteasome regulatory subunit 6B	0	0	2	2
Mitogen-activated protein kinase 8	0	0	2	2
Mitogen-activated protein kinase 9	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 3	0	0	2	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	2	2
Casein kinase I isoform alpha	0	0	2	2
Casein kinase I isoform delta	0	0	2	2
MAP kinase-activated protein kinase 2	0	0	2	2
Elongation factor Tu, mitochondrial	0	0	2	2
Choline-phosphate cytidylyltransferase A	0	0	2	2
Cysteine--tRNA ligase, cytoplasmic	0	0	2	2
Casein kinase I isoform epsilon	0	0	2	2
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	2	2
Dual specificity protein kinase CLK1	0	0	2	2
Dual specificity protein kinase CLK2	0	0	2	2
Dual specificity protein kinase CLK3	0	0	2	2
Glycogen synthase kinase-3 alpha	0	0	2	2
Glycogen synthase kinase-3 beta	0	1	3	4
Cyclin-dependent kinase 7	0	0	2	2
Cyclin-dependent kinase 9	0	0	2	2
Ras-related protein Rab-27A	0	0	2	2
Interleukin-1 receptor-associated kinase 1	0	0	2	2
Potassium voltage-gated channel subfamily KQT member 1	0	3	0	3
Ribosomal protein S6 kinase alpha-3	0	0	2	2
Serine/threonine-protein kinase Nek2	0	0	2	2
Serine/threonine-protein kinase Nek3	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 6	0	0	2	2
Serine/threonine-protein kinase PLK1	0	0	2	2
LIM domain kinase 1	0	0	2	2
LIM domain kinase 2	0	0	2	2
Mitogen-activated protein kinase 10	0	0	2	2
Tyrosine--tRNA ligase, cytoplasmic	0	0	2	2
5'-AMP-activated protein kinase subunit gamma-1	0	0	2	3
Ephrin type-B receptor 3	0	0	2	2
Ephrin type-A receptor 5	0	0	2	2
Ephrin type-B receptor 4	0	0	2	2
Ephrin type-A receptor 4	0	0	2	2
Adenylate kinase 2, mitochondrial	0	0	2	2
Ras-related protein Rab-10	0	0	2	2
Actin-related protein 3	0	0	2	2
Actin-related protein 2	0	0	2	2
GTP-binding nuclear protein Ran	0	0	2	2
Casein kinase I isoform gamma-2	0	0	2	2
Cyclin-dependent kinase 3	0	0	1	1
Cyclin-dependent kinase 6	0	0	2	2
Cyclin-dependent-like kinase 5	0	0	2	2
Cyclin-dependent kinase 16	0	0	2	2
Cyclin-dependent kinase 17	0	0	2	2
ATP-dependent 6-phosphofructokinase, platelet type	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 1	0	0	2	2
Protein kinase C theta type	0	0	2	2
Activin receptor type-1	0	0	2	2
Macrophage-stimulating protein receptor	0	0	2	2
Focal adhesion kinase 1	0	0	2	2
Protein kinase C delta type	0	0	2	2
Tyrosine-protein kinase BTK	0	0	2	2
Activated CDC42 kinase 1	0	0	2	2
Epithelial discoidin domain-containing receptor 1	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	2	2
Serine/threonine-protein kinase 4	0	0	2	2
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	2	3
Dual specificity mitogen-activated protein kinase kinase 5	0	0	2	2
Mitogen-activated protein kinase 7	0	0	2	2
Serine/threonine-protein kinase PAK 2	0	0	2	2
Serine/threonine-protein kinase 3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 1	0	0	2	2
Integrin-linked protein kinase	0	0	2	2
Rho-associated protein kinase 1	0	0	2	2
Non-receptor tyrosine-protein kinase TNK1	0	0	2	2
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	2	2
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	2	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	2	2
Activin receptor type-2B	0	0	2	2
Bone morphogenetic protein receptor type-2	0	0	2	2
Protein-tyrosine kinase 6	0	0	2	2
cGMP-dependent protein kinase 1	0	0	2	2
Cyclin-dependent kinase 13	0	0	2	2
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	2	2
Protein-tyrosine kinase 2-beta	0	0	2	2
Sodium channel protein type 5 subunit alpha	0	7	0	7
Maternal embryonic leucine zipper kinase	0	0	2	2
Structural maintenance of chromosomes protein 1A	0	0	2	2
Chromodomain-helicase-DNA-binding protein 4	0	0	2	2
Peroxisomal acyl-coenzyme A oxidase 1	0	0	2	2
Ephrin type-A receptor 7	0	0	1	1
Delta(24)-sterol reductase	0	0	2	2
Ribosomal protein S6 kinase alpha-1	0	0	2	2
Dual specificity testis-specific protein kinase 1	0	0	2	2
Myosin light chain kinase, smooth muscle	0	0	2	2
Mitogen-activated protein kinase 11	0	1	2	3
Serine/threonine-protein kinase STK11	0	0	2	2
Serine/threonine-protein kinase N1	0	0	2	2
Serine/threonine-protein kinase N2	0	0	2	2
Mitogen-activated protein kinase 14	0	1	2	3
Calcium/calmodulin-dependent protein kinase type IV	0	0	2	2
Mitogen-activated protein kinase kinase kinase 11	0	0	2	2
Discoidin domain-containing receptor 2	0	0	2	2
AP2-associated protein kinase 1	0	0	2	2
Myosin light chain kinase 3	0	0	2	2
Putative heat shock protein HSP 90-beta 2	0	0	2	2
Serine/threonine-protein kinase MRCK alpha	0	0	2	2
Serine/threonine-protein kinase MRCK gamma	0	0	2	2
Acyl-CoA dehydrogenase family member 10	0	0	2	2
Serine/threonine-protein kinase N3	0	0	2	2
Serine/threonine-protein kinase ULK3	0	0	2	2
Uncharacterized protein FLJ45252	0	0	2	2
Acyl-CoA dehydrogenase family member 11	0	0	2	2
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	2	2
Serine/threonine-protein kinase MARK2	0	0	2	2
ATP-dependent RNA helicase DHX30	0	0	2	2
Serine/threonine-protein kinase TAO1	0	0	2	2
STE20-related kinase adapter protein alpha	0	0	2	2
Myosin-14	0	0	2	2
AarF domain-containing protein kinase 1	0	0	2	2
ATP-dependent RNA helicase DDX42	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	2	2
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	1	1
Regulatory-associated protein of mTOR	0	2	0	2
Atypical kinase COQ8A, mitochondrial	0	0	2	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	2	2
Mitogen-activated protein kinase 15	0	0	2	2
Serine/threonine-protein kinase Nek9	0	0	2	2
Serine/threonine-protein kinase Nek7	0	0	1	1
ATP-dependent RNA helicase DDX1	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	2	2
Aurora kinase B	0	0	2	2
MAP/microtubule affinity-regulating kinase 4	0	0	2	2
Serine/threonine-protein kinase Nek1	0	0	2	2
PAS domain-containing serine/threonine-protein kinase	0	0	2	2
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	2	2
EKC/KEOPS complex subunit TP53RK	0	0	2	2
Dual specificity testis-specific protein kinase 2	0	0	2	2
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	2	2
Mitogen-activated protein kinase kinase kinase 5	0	0	2	2
Mitogen-activated protein kinase kinase kinase 3	0	0	2	2
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	2	2
Target of rapamycin complex subunit LST8	0	2	0	2
Nucleolar GTP-binding protein 1	0	0	2	2
Serine/threonine-protein kinase D2	0	0	2	2
NUAK family SNF1-like kinase 2	0	0	1	1
RNA cytidine acetyltransferase	0	0	2	2
Serine/threonine-protein kinase SIK2	0	0	2	2
STE20-like serine/threonine-protein kinase	0	0	2	2
Serine/threonine-protein kinase TAO3	0	0	2	2
dCTP pyrophosphatase 1	0	0	2	2
Dual specificity protein kinase CLK4	0	0	2	2
Casein kinase I isoform gamma-1	0	0	2	2
Phenylalanine--tRNA ligase beta subunit	0	0	2	2
BMP-2-inducible protein kinase	0	0	2	2
Obg-like ATPase 1	0	0	2	2
Midasin	0	0	2	2
Interleukin-1 receptor-associated kinase 4	0	0	2	2
Mitogen-activated protein kinase kinase kinase 20	0	0	2	2
Cyclin-dependent kinase 12	0	0	2	2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	1	1
Serine/threonine-protein kinase 26	0	0	2	2
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	2	2
Serine/threonine-protein kinase NLK	0	0	2	2
5'-AMP-activated protein kinase subunit gamma-2	0	0	2	3
Serine/threonine-protein kinase TBK1	0	0	2	2
Septin-9	0	0	2	2
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
Ribosomal protein S6 kinase alpha-6	0	0	2	2
TRAF2 and NCK-interacting protein kinase	0	0	2	2
Serine/threonine-protein kinase TAO2	0	0	2	2
Long-chain-fatty-acid--CoA ligase 5	0	0	1	1
RAC-gamma serine/threonine-protein kinase	0	0	2	2
Serine/threonine-protein kinase SIK3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 2	0	0	2	2
Thyroid hormone receptor-associated protein 3	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	2	2
Receptor-interacting serine/threonine-protein kinase 3	0	0	2	2
Serine/threonine-protein kinase MRCK beta	0	0	2	2
Interleukin-1 receptor-associated kinase 3	0	0	2	2
Casein kinase I isoform gamma-3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 4	0	0	2	2
Potassium voltage-gated channel subfamily KQT member 3	0	0	1	3
Potassium voltage-gated channel subfamily KQT member 2	0	0	1	3
UDP-glucuronosyltransferase 1A9	0	0	1	3
UDP-glucuronosyltransferase 2B11	0	0	1	1
UDP-glucuronosyltransferase 2B17	0	0	1	1
Potassium voltage-gated channel subfamily KQT member 2	0	0	1	1
Potassium voltage-gated channel subfamily KQT member 3	0	0	1	1
UDP-glucuronosyltransferase 2B4	0	0	1	1
UDP-glucuronosyltransferase 2A1	0	0	1	1
UDP-glucuronosyltransferase 2A2	0	0	1	1
UDP-glucuronosyltransferase 1-6	0	2	1	4
UDP-glucuronosyltransferase 1A3	0	0	1	2
UDP-glucuronosyltransferase 1A5	0	0	1	1
UDP-glucuronosyltransferase 2B10	0	2	1	3
UDP-glucuronosyltransferase 2B15	0	0	1	1
Potassium voltage-gated channel subfamily KQT member 4	0	0	1	1
UDP-glucuronosyltransferase 2A3	0	0	1	1
UDP-glucuronosyltransferase 2B28	0	0	1	1
UDP-glucuronosyltransferase 1A7	0	0	1	1
UDP-glucuronosyltransferase 1A10	0	0	1	1
UDP-glucuronosyltransferase 1A8	0	0	1	3
Potassium voltage-gated channel subfamily KQT member 5	0	0	1	2
Potassium voltage-gated channel subfamily KQT member 2	0	0	1	1
pyruvate kinase PKM isoform b	1	0	0	1
Ornithine decarboxylase	1	0	0	1
Glutamate receptor ionotropic, NMDA 2B	0	4	1	6
serine-protein kinase ATM isoform a	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
Fatty acid-binding protein, liver	0	1	0	1
Fatty acid-binding protein, intestinal	0	1	1	2
Peroxisome proliferator-activated receptor alpha	0	0	1	1
Cruzipain	0	1	0	1
Peroxisome proliferator-activated receptor alpha	0	0	1	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Delta-type opioid receptor	0	9	1	12
Delta-type opioid receptor	0	10	2	13
Mu-type opioid receptor	0	13	4	20
Kappa-type opioid receptor	0	6	2	9
Kappa-type opioid receptor	0	7	0	8
Mu-type opioid receptor	0	5	2	10
Mu-type opioid receptor	0	9	1	11
Sigma non-opioid intracellular receptor 1	0	6	1	7
Sphingosine 1-phosphate receptor 1	0	1	2	3
RCG53912, isoform CRA_a	0	0	0	1
Sphingosine kinase 1	0	0	0	1
Sphingosine kinase 2	0	1	0	2
Sphingosine kinase 1	0	1	0	2
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
Sodium-dependent noradrenaline transporter	0	1	0	1
Cytochrome P450 2C8	0	5	0	5
Dipeptidyl peptidase 4	0	1	0	1
Acetylcholinesterase	0	2	0	2
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
D(1A) dopamine receptor	2	0	0	2
Gastrin/cholecystokinin type B receptor	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Beta-2 adrenergic receptor	0	2	0	2
Chain A, Dihydrofolate reductase	0	0	1	1
Thymidylate synthase	0	4	0	4
Thymidylate synthase	0	3	0	3
Dihydrofolate reductase	0	4	3	7
Aldo-keto reductase family 1 member B1	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Solute carrier organic anion transporter family member 1A3	0	1	0	4
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Multidrug resistance associated protein	0	1	0	3
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	3	4
transcriptional regulator ERG isoform 3	5	0	0	5
Sodium- and chloride-dependent GABA transporter 1	0	6	0	6
Gamma-aminobutyric acid receptor subunit rho-2	0	0	2	2
Sodium- and chloride-dependent GABA transporter 1	0	3	1	6
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	6	0	6
Sodium- and chloride-dependent GABA transporter 3	0	5	0	5
Sodium- and chloride-dependent GABA transporter 1	0	3	0	3
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	5	0	5
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	2
Sterol O-acyltransferase 1	0	0	1	1
Platelet glycoprotein VI	0	1	2	4
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
Metabotropic glutamate receptor 8	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	3	0	3
Glutamate receptor ionotropic, NMDA 3B	0	3	0	3
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Glutamate receptor ionotropic, kainate 1	0	6	2	9
Metabotropic glutamate receptor 1	0	2	1	3
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	1	2	3
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	3	2	5
Metabotropic glutamate receptor 5	0	1	2	4
Glutamate receptor ionotropic, kainate 2	0	6	3	10
Metabotropic glutamate receptor 8	0	0	1	1
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	3	0	3
Glutamate receptor ionotropic, kainate 4	0	6	0	7
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	4	0	4
Glutamate receptor ionotropic, NMDA 2A	0	4	0	4
Glutamate receptor ionotropic, kainate 2	0	3	2	5
Glutamate receptor ionotropic, kainate 3	0	3	0	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	3	0	3
Glutamate receptor ionotropic, kainate 5	0	3	0	3
Glutamate receptor ionotropic, kainate 5	0	6	0	7
Glutamate racemase	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	3	0	3
Chain A, Glutamine Binding Protein	0	0	1	1
Asc-type amino acid transporter 1	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
GALC protein	4	0	0	4
apical membrane antigen 1, AMA1	4	0	0	4
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Solute carrier family 22 member 3	0	1	0	2
Plasma kallikrein	0	0	0	2
Macrophage migration inhibitory factor	0	3	0	3
Carbonic anhydrase	0	3	0	6
Histamine H3 receptor	0	2	0	2
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	2	0	5
Carbonic anhydrase	0	1	0	4
Carbonic anhydrase	0	3	0	6
Carbonic anhydrase	0	2	0	5
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	5	0	6
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Histamine H3 receptor	0	2	1	3
Carboxylic ester hydrolase	0	0	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
ClpP	3	0	0	3
Solute carrier family 22 member 8	0	0	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	2	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	2	0	2
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
Amyloid-beta precursor protein	0	1	0	1
Sodium/myo-inositol cotransporter 2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Large neutral amino acids transporter small subunit 1	0	2	0	2
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
N-glycosylase/DNA lyase	0	1	0	1
Myeloperoxidase	0	4	0	4
Formamidopyrimidine-DNA glycosylase	0	1	0	1
Endonuclease III-like protein 1	0	1	0	1
Pantothenate synthetase	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Endonuclease 8-like 1	0	1	0	1
Chain A, Glutamate receptor 2	0	0	1	1
Chain A, Glutamate receptor 2	0	0	1	1
Chain C, Glutamate receptor 2	0	0	1	1
Glutamate receptor ionotropic, kainate 4	0	1	0	1
Estrogen receptor beta	0	1	0	2
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	2	0	2
Cytochrome P450 26A1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Camphor 5-monooxygenase	0	0	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Steroid 21-hydroxylase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	3
Cytochrome P450 2A2	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Cytochrome P450 7A1	0	1	0	1
Estrogen receptor	0	1	0	2
Gonadotropin-releasing hormone receptor	0	1	1	2
Type-1 angiotensin II receptor	0	2	1	3
Cytochrome P450 4F2	0	1	0	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	2	0	2
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Cytochrome P450 7A1	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Parkin	3	0	0	3
Mitogen-activated protein kinase 13	0	1	0	1
Aryl hydrocarbon receptor	0	0	1	1
Mitogen-activated protein kinase 12	0	1	0	1
G protein-coupled receptor GPR35	0	0	1	1
Vesicular glutamate transporter 3	0	1	0	1
G-protein coupled receptor 35	0	2	1	3
Histamine H3 receptor	0	1	1	2
Sodium channel protein type 10 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	3	0	3
Sodium channel protein type 3 subunit alpha	0	3	0	3
Sodium channel protein type 10 subunit alpha	0	1	0	1
Synaptic vesicle glycoprotein 2A	0	3	0	3
inositol monophosphatase 1	1	0	0	1
5-hydroxytryptamine receptor 2C	0	0	1	1
Neprilysin	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Atrial natriuretic peptide receptor 3	0	1	0	1
Thromboxane A2 receptor	0	1	0	2
Type-1A angiotensin II receptor	0	3	1	4
Type-1B angiotensin II receptor	0	4	0	4
Type-1 angiotensin II receptor	0	2	1	5
Type-2 angiotensin II receptor	0	3	0	3
Type-2 angiotensin II receptor	0	1	0	1
Squalene synthase	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	3	0	3
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	3	0	3
Multidrug and toxin extrusion protein 1	0	4	0	4
Type-1 angiotensin II receptor	0	2	1	3
Cytochrome P450 1A2	0	1	0	1
Acetylcholinesterase	0	1	0	1
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Carboxylic ester hydrolase	0	1	0	1
Dihydrofolate reductase	0	5	0	6
Dipeptidyl peptidase 4	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	2	3
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	2	1	5
Reduced folate transporter	0	2	0	2
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Pteridine reductase 1	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
tumor susceptibility gene 101 protein	1	0	0	1
Serine racemase	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Lactoperoxidase	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	2
5-hydroxytryptamine receptor 3B	0	1	0	1
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Integrin alpha-4	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Proteinase-activated receptor 1	0	1	1	2
Kappa-type opioid receptor	0	4	2	7
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
D-amino-acid oxidase	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
Nociceptin receptor	0	1	0	1
Atrial natriuretic peptide receptor 1	0	1	0	1
Neuropeptide Y receptor type 1	0	2	0	2
Neuropeptide Y receptor type 2	0	2	0	2
Voltage-dependent L-type calcium channel subunit beta-4	0	1	0	1
Voltage-dependent P/Q-type calcium channel subunit alpha-1A	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1G	0	1	0	1
Voltage-dependent calcium channel gamma-3 subunit	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1H	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-3	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	2	0	3
Voltage-dependent calcium channel gamma-7 subunit	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-1	0	1	0	1
Voltage-dependent calcium channel gamma-1 subunit	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-2	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	3	0	3
Voltage-dependent R-type calcium channel subunit alpha-1E	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-4	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Voltage-dependent calcium channel subunit alpha-2/delta-3	0	1	0	1
Voltage-dependent calcium channel gamma-8 subunit	0	1	0	1
Voltage-dependent calcium channel gamma-6 subunit	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	2	0	2
Voltage-dependent calcium channel gamma-4 subunit	0	1	0	1
Voltage-dependent calcium channel gamma-5 subunit	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	0	1	0	1
polyadenylate-binding protein 1	0	2	0	2
bcl-2-related protein A1	0	2	0	2
Sodium channel protein type 1 subunit alpha	0	2	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Cytochrome P450 2A13	0	1	1	2
Glutamate 5-kinase	0	0	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
histone deacetylase 9 isoform 3	1	0	0	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	1	0	1
P2X purinoceptor 4	0	0	1	1
Trans-sialidase	0	1	0	1
Trans-sialidase	0	1	0	1
P2X purinoceptor 2	0	0	1	1
Solute carrier organic anion transporter family member 1A4	0	2	0	4
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Cytochrome P450 2D4	0	1	0	1
Multidrug resistance protein 1a	0	0	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Coagulation factor X	0	1	0	1
Pancreatic triacylglycerol lipase	0	1	0	1
NADH-ubiquinone oxidoreductase chain 1	0	1	0	1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	0	1	0	1
Dihydroorotate dehydrogenase (fumarate)	0	1	0	1
Acyl carrier protein, mitochondrial	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
Met repressor	0	0	2	2
Protein arginine N-methyltransferase 5	0	0	1	1
Histone H3K27 methylase	0	0	0	1
Phenylethanolamine N-methyltransferase	0	0	1	2
S-adenosylmethionine decarboxylase proenzyme	0	1	0	2
Protein-L-isoaspartate(D-aspartate) O-methyltransferase	0	1	0	1
Catechol O-methyltransferase	0	0	0	1
Protein arginine N-methyltransferase 1	0	1	0	1
Methylosome protein 50	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Monoglyceride lipase	0	1	0	1
C-X-C chemokine receptor type 2	0	1	0	1
Pyruvate kinase PKM	0	0	1	1
Cholecystokinin receptor type A	0	1	0	1
Cholecystokinin receptor type A	0	2	2	4
Gastrin/cholecystokinin type B receptor	0	2	2	4
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Tyrosine-protein kinase JAK2	0	0	1	1
Cyclin-dependent kinase-like 5	0	0	1	1
Eukaryotic translation initiation factor 4E	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
Serine/threonine-protein kinase receptor R3	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	4	2	6
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	2	2
Protein kinase C zeta type	0	0	1	1
Cyclin-dependent kinase 18	0	0	1	1
Tyrosine-protein kinase Mer	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	2	0	2
Uncharacterized aarF domain-containing protein kinase 5	0	0	1	1
Programmed cell death protein 4	0	0	1	1
MAP kinase-activated protein kinase 5	0	0	1	1
Misshapen-like kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1G	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Isoleucine--tRNA ligase, mitochondrial	0	0	1	1
Serine/threonine-protein kinase ICK	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	1	1
Serine/threonine-protein kinase 24	0	0	1	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Caspase-2	0	0	1	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
C-X-C chemokine receptor type 5 isoform 1	0	1	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
C-C chemokine receptor type 6	0	1	0	1
apelin receptor	0	1	0	1
Endoglycoceramidase II	0	0	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Protein kinase C eta type	0	1	0	1
Protein kinase C theta type	0	1	0	1
Sphingosine 1-phosphate receptor 2	0	1	1	2
Sphingosine 1-phosphate receptor 4	0	1	1	2
Sphingosine 1-phosphate receptor 3	0	1	1	2
Sphingosine 1-phosphate receptor 5	0	1	1	2
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase	0	3	0	3
Beta-carbonic anhydrase 1	0	3	0	3
Carbonic anhydrase 2	0	3	0	3
Carbonic anhydrase, alpha family	0	3	0	3
Carbonic anhydrase	0	3	0	3
Delta carbonic anhydrase	0	3	0	3
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Thioredoxin reductase 1, cytoplasmic	0	1	0	1
Thioredoxin reductase 3	0	1	0	1
Thioredoxin reductase 2, mitochondrial	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Transthyretin	0	1	0	3
Thyroid hormone receptor alpha	0	2	3	5
Thyroid hormone receptor beta	0	2	3	5
Proliferating cell nuclear antigen	0	2	0	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	2
Solute carrier organic anion transporter family member 4C1	0	1	0	2
Monocarboxylate transporter 8	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Chain A, Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	2	0	2
Prolyl endopeptidase	0	2	0	2
Carbonic anhydrase-related protein 11	0	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Arachidonate 5-lipoxygenase-activating protein	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	2	0	2
Chain A, PLASMINOGEN	0	0	1	1
Chain A, PLASMINOGEN	0	0	1	1
Plasminogen	0	2	1	3
Urokinase-type plasminogen activator	0	1	0	1
Androgen receptor	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Substance-P receptor	0	1	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
SLC16A10 protein	0	0	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Monocarboxylate transporter 10	0	0	0	1
Phospholipase A-2-activating protein	0	1	0	1
Chain A, Cytidine Deaminase	0	1	0	1
Cytidine deaminase	0	1	0	1
Protein cereblon	0	2	0	2
Uridine-cytidine kinase 1	0	0	0	1
Cocaine esterase	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Liver carboxylesterase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Glycoprotein	0	1	0	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Catechol O-methyltransferase	0	1	0	1
Chloroquine resistance transporter	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Phosphodiesterase	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	2	0	2
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
Carbonic anhydrase 2	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Amine oxidase [flavin-containing]	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(8)

Research Excerpts

Overview

Context

Treatment

Research

Studies (719)

Protein Targets (1,664)

Drug Refractory Epilepsy

Synonyms(8)

Research Excerpts

Overview

Context

Treatment

Research

Studies (719)

Drugs Studied (241)

Protein Targets (1,664)