Compounds > 1-aminoadenosine
Page last updated: 2024-11-08

1-aminoadenosine

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Description

1-aminoadenosine: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID7075199
CHEMBL ID236757
SCHEMBL ID8712645
MeSH IDM0049092

Synonyms (11)

Synonym
inosine, hydrazone
nsc 29408
9h-purine, 6-hydrazino-9-beta-d-ribofuranosyl-
CHEMBL236757 ,
n6-aminoadenosine
1-aminoadenosine
bdbm50214817
SCHEMBL8712645
AKOS030488442
n-aminoadenosine
(2r,3r,4s,5r)-2-(6-hydrazinyl-9h-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (6)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Heat shock protein HSP 90-alphaHomo sapiens (human)Ki3.00000.00020.54152.7000AID1694547
EndoplasminHomo sapiens (human)Ki10.00000.00401.32057.0000AID1694546
Adenosine receptor A3Rattus norvegicus (Norway rat)Ki16.90000.00030.91969.0000AID33337
Ribonucleoside-diphosphate reductase subunit M2Homo sapiens (human)IC50 (µMol)238.00000.18500.18500.1850AID595464; AID595465
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Heat shock protein HSP 90-alphaHomo sapiens (human)Kd50.00000.00030.94889.8000AID1694547
EndoplasminHomo sapiens (human)Kd50.00000.20001.93908.6000AID1694546
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (74)

Processvia Protein(s)Taxonomy
telomere maintenance via telomeraseHeat shock protein HSP 90-alphaHomo sapiens (human)
neuron migrationHeat shock protein HSP 90-alphaHomo sapiens (human)
positive regulation of protein phosphorylationHeat shock protein HSP 90-alphaHomo sapiens (human)
activation of innate immune responseHeat shock protein HSP 90-alphaHomo sapiens (human)
positive regulation of defense response to virus by hostHeat shock protein HSP 90-alphaHomo sapiens (human)
skeletal muscle contractionHeat shock protein HSP 90-alphaHomo sapiens (human)
mitochondrial transportHeat shock protein HSP 90-alphaHomo sapiens (human)
response to unfolded proteinHeat shock protein HSP 90-alphaHomo sapiens (human)
response to heatHeat shock protein HSP 90-alphaHomo sapiens (human)
response to coldHeat shock protein HSP 90-alphaHomo sapiens (human)
response to xenobiotic stimulusHeat shock protein HSP 90-alphaHomo sapiens (human)
response to salt stressHeat shock protein HSP 90-alphaHomo sapiens (human)
positive regulation of lamellipodium assemblyHeat shock protein HSP 90-alphaHomo sapiens (human)
cardiac muscle cell apoptotic processHeat shock protein HSP 90-alphaHomo sapiens (human)
regulation of protein ubiquitinationHeat shock protein HSP 90-alphaHomo sapiens (human)
positive regulation of protein polymerizationHeat shock protein HSP 90-alphaHomo sapiens (human)
positive regulation of interferon-beta productionHeat shock protein HSP 90-alphaHomo sapiens (human)
regulation of protein localizationHeat shock protein HSP 90-alphaHomo sapiens (human)
protein refoldingHeat shock protein HSP 90-alphaHomo sapiens (human)
response to cocaineHeat shock protein HSP 90-alphaHomo sapiens (human)
positive regulation of protein import into nucleusHeat shock protein HSP 90-alphaHomo sapiens (human)
regulation of apoptotic processHeat shock protein HSP 90-alphaHomo sapiens (human)
regulation of protein-containing complex assemblyHeat shock protein HSP 90-alphaHomo sapiens (human)
protein unfoldingHeat shock protein HSP 90-alphaHomo sapiens (human)
response to estrogenHeat shock protein HSP 90-alphaHomo sapiens (human)
protein insertion into mitochondrial outer membraneHeat shock protein HSP 90-alphaHomo sapiens (human)
positive regulation of nitric oxide biosynthetic processHeat shock protein HSP 90-alphaHomo sapiens (human)
positive regulation of protein catabolic processHeat shock protein HSP 90-alphaHomo sapiens (human)
positive regulation of cell sizeHeat shock protein HSP 90-alphaHomo sapiens (human)
response to antibioticHeat shock protein HSP 90-alphaHomo sapiens (human)
protein stabilizationHeat shock protein HSP 90-alphaHomo sapiens (human)
chaperone-mediated protein complex assemblyHeat shock protein HSP 90-alphaHomo sapiens (human)
positive regulation of cardiac muscle contractionHeat shock protein HSP 90-alphaHomo sapiens (human)
chaperone-mediated autophagyHeat shock protein HSP 90-alphaHomo sapiens (human)
cellular response to virusHeat shock protein HSP 90-alphaHomo sapiens (human)
regulation of postsynaptic membrane neurotransmitter receptor levelsHeat shock protein HSP 90-alphaHomo sapiens (human)
positive regulation of tau-protein kinase activityHeat shock protein HSP 90-alphaHomo sapiens (human)
telomerase holoenzyme complex assemblyHeat shock protein HSP 90-alphaHomo sapiens (human)
cellular response to heatHeat shock protein HSP 90-alphaHomo sapiens (human)
protein foldingHeat shock protein HSP 90-alphaHomo sapiens (human)
actin rod assemblyEndoplasminHomo sapiens (human)
regulation of phosphoprotein phosphatase activityEndoplasminHomo sapiens (human)
cellular response to ATPEndoplasminHomo sapiens (human)
response to hypoxiaEndoplasminHomo sapiens (human)
protein transportEndoplasminHomo sapiens (human)
retrograde protein transport, ER to cytosolEndoplasminHomo sapiens (human)
protein folding in endoplasmic reticulumEndoplasminHomo sapiens (human)
response to endoplasmic reticulum stressEndoplasminHomo sapiens (human)
ERAD pathwayEndoplasminHomo sapiens (human)
negative regulation of apoptotic processEndoplasminHomo sapiens (human)
sequestering of calcium ionEndoplasminHomo sapiens (human)
cellular response to manganese ionEndoplasminHomo sapiens (human)
protein foldingEndoplasminHomo sapiens (human)
DNA synthesis involved in DNA repairRibonucleoside-diphosphate reductase large subunitHomo sapiens (human)
pyrimidine nucleobase metabolic processRibonucleoside-diphosphate reductase large subunitHomo sapiens (human)
mitochondrial DNA replicationRibonucleoside-diphosphate reductase large subunitHomo sapiens (human)
DNA repairRibonucleoside-diphosphate reductase large subunitHomo sapiens (human)
male gonad developmentRibonucleoside-diphosphate reductase large subunitHomo sapiens (human)
ribonucleoside diphosphate metabolic processRibonucleoside-diphosphate reductase large subunitHomo sapiens (human)
deoxyribonucleotide biosynthetic processRibonucleoside-diphosphate reductase large subunitHomo sapiens (human)
2'-deoxyribonucleotide biosynthetic processRibonucleoside-diphosphate reductase large subunitHomo sapiens (human)
response to ionizing radiationRibonucleoside-diphosphate reductase large subunitHomo sapiens (human)
positive regulation of G2/M transition of mitotic cell cycleRibonucleoside-diphosphate reductase large subunitHomo sapiens (human)
cell proliferation in forebrainRibonucleoside-diphosphate reductase large subunitHomo sapiens (human)
protein heterotetramerizationRibonucleoside-diphosphate reductase large subunitHomo sapiens (human)
retina development in camera-type eyeRibonucleoside-diphosphate reductase large subunitHomo sapiens (human)
positive regulation of G0 to G1 transitionRibonucleoside-diphosphate reductase large subunitHomo sapiens (human)
positive regulation of G1/S transition of mitotic cell cycleRibonucleoside-diphosphate reductase large subunitHomo sapiens (human)
blastocyst developmentRibonucleoside-diphosphate reductase subunit M2Homo sapiens (human)
ribonucleoside diphosphate metabolic processRibonucleoside-diphosphate reductase subunit M2Homo sapiens (human)
deoxyribonucleotide biosynthetic processRibonucleoside-diphosphate reductase subunit M2Homo sapiens (human)
2'-deoxyribonucleotide biosynthetic processRibonucleoside-diphosphate reductase subunit M2Homo sapiens (human)
protein heterotetramerizationRibonucleoside-diphosphate reductase subunit M2Homo sapiens (human)
positive regulation of G1/S transition of mitotic cell cycleRibonucleoside-diphosphate reductase subunit M2Homo sapiens (human)
DNA synthesis involved in DNA repairRibonucleoside-diphosphate reductase subunit M2 BHomo sapiens (human)
kidney developmentRibonucleoside-diphosphate reductase subunit M2 BHomo sapiens (human)
renal system processRibonucleoside-diphosphate reductase subunit M2 BHomo sapiens (human)
mitochondrial DNA replicationRibonucleoside-diphosphate reductase subunit M2 BHomo sapiens (human)
DNA repairRibonucleoside-diphosphate reductase subunit M2 BHomo sapiens (human)
response to oxidative stressRibonucleoside-diphosphate reductase subunit M2 BHomo sapiens (human)
ribonucleoside diphosphate metabolic processRibonucleoside-diphosphate reductase subunit M2 BHomo sapiens (human)
deoxyribonucleoside triphosphate metabolic processRibonucleoside-diphosphate reductase subunit M2 BHomo sapiens (human)
2'-deoxyribonucleotide biosynthetic processRibonucleoside-diphosphate reductase subunit M2 BHomo sapiens (human)
positive regulation of G2/M transition of mitotic cell cycleRibonucleoside-diphosphate reductase subunit M2 BHomo sapiens (human)
response to amineRibonucleoside-diphosphate reductase subunit M2 BHomo sapiens (human)
positive regulation of G0 to G1 transitionRibonucleoside-diphosphate reductase subunit M2 BHomo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediatorRibonucleoside-diphosphate reductase subunit M2 BHomo sapiens (human)
deoxyribonucleotide biosynthetic processRibonucleoside-diphosphate reductase subunit M2 BHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (34)

Processvia Protein(s)Taxonomy
UTP bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
CTP bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
RNA bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
mRNA bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
protein bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
ATP bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
GTP bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
ATP hydrolysis activityHeat shock protein HSP 90-alphaHomo sapiens (human)
sulfonylurea receptor bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
protein phosphatase bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
MHC class II protein complex bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
nitric-oxide synthase regulator activityHeat shock protein HSP 90-alphaHomo sapiens (human)
TPR domain bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
ubiquitin protein ligase bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
dATP bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
identical protein bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
protein homodimerization activityHeat shock protein HSP 90-alphaHomo sapiens (human)
histone deacetylase bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
transmembrane transporter bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
tau protein bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
GTPase bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
Rho GDP-dissociation inhibitor bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
DNA polymerase bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
scaffold protein bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
disordered domain specific bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
ATP-dependent protein folding chaperoneHeat shock protein HSP 90-alphaHomo sapiens (human)
protein tyrosine kinase bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
unfolded protein bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
RNA bindingEndoplasminHomo sapiens (human)
calcium ion bindingEndoplasminHomo sapiens (human)
protein bindingEndoplasminHomo sapiens (human)
ATP bindingEndoplasminHomo sapiens (human)
ATP hydrolysis activityEndoplasminHomo sapiens (human)
protein phosphatase bindingEndoplasminHomo sapiens (human)
low-density lipoprotein particle receptor bindingEndoplasminHomo sapiens (human)
ATP-dependent protein folding chaperoneEndoplasminHomo sapiens (human)
unfolded protein bindingEndoplasminHomo sapiens (human)
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptorRibonucleoside-diphosphate reductase large subunitHomo sapiens (human)
protein bindingRibonucleoside-diphosphate reductase large subunitHomo sapiens (human)
identical protein bindingRibonucleoside-diphosphate reductase large subunitHomo sapiens (human)
ribonucleoside-diphosphate reductase activityRibonucleoside-diphosphate reductase large subunitHomo sapiens (human)
disordered domain specific bindingRibonucleoside-diphosphate reductase large subunitHomo sapiens (human)
ATP bindingRibonucleoside-diphosphate reductase large subunitHomo sapiens (human)
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptorRibonucleoside-diphosphate reductase subunit M2Homo sapiens (human)
protein bindingRibonucleoside-diphosphate reductase subunit M2Homo sapiens (human)
ferric iron bindingRibonucleoside-diphosphate reductase subunit M2Homo sapiens (human)
protein homodimerization activityRibonucleoside-diphosphate reductase subunit M2Homo sapiens (human)
protein bindingRibonucleoside-diphosphate reductase subunit M2 BHomo sapiens (human)
identical protein bindingRibonucleoside-diphosphate reductase subunit M2 BHomo sapiens (human)
metal ion bindingRibonucleoside-diphosphate reductase subunit M2 BHomo sapiens (human)
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptorRibonucleoside-diphosphate reductase subunit M2 BHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (38)

Processvia Protein(s)Taxonomy
extracellular regionHeat shock protein HSP 90-alphaHomo sapiens (human)
nucleusHeat shock protein HSP 90-alphaHomo sapiens (human)
nucleoplasmHeat shock protein HSP 90-alphaHomo sapiens (human)
cytoplasmHeat shock protein HSP 90-alphaHomo sapiens (human)
mitochondrionHeat shock protein HSP 90-alphaHomo sapiens (human)
cytosolHeat shock protein HSP 90-alphaHomo sapiens (human)
plasma membraneHeat shock protein HSP 90-alphaHomo sapiens (human)
cell surfaceHeat shock protein HSP 90-alphaHomo sapiens (human)
membraneHeat shock protein HSP 90-alphaHomo sapiens (human)
basolateral plasma membraneHeat shock protein HSP 90-alphaHomo sapiens (human)
apical plasma membraneHeat shock protein HSP 90-alphaHomo sapiens (human)
brush border membraneHeat shock protein HSP 90-alphaHomo sapiens (human)
secretory granule lumenHeat shock protein HSP 90-alphaHomo sapiens (human)
melanosomeHeat shock protein HSP 90-alphaHomo sapiens (human)
neuronal cell bodyHeat shock protein HSP 90-alphaHomo sapiens (human)
lysosomal lumenHeat shock protein HSP 90-alphaHomo sapiens (human)
dendritic growth coneHeat shock protein HSP 90-alphaHomo sapiens (human)
axonal growth coneHeat shock protein HSP 90-alphaHomo sapiens (human)
perinuclear region of cytoplasmHeat shock protein HSP 90-alphaHomo sapiens (human)
collagen-containing extracellular matrixHeat shock protein HSP 90-alphaHomo sapiens (human)
extracellular exosomeHeat shock protein HSP 90-alphaHomo sapiens (human)
endocytic vesicle lumenHeat shock protein HSP 90-alphaHomo sapiens (human)
sperm mitochondrial sheathHeat shock protein HSP 90-alphaHomo sapiens (human)
sperm plasma membraneHeat shock protein HSP 90-alphaHomo sapiens (human)
ficolin-1-rich granule lumenHeat shock protein HSP 90-alphaHomo sapiens (human)
protein-containing complexHeat shock protein HSP 90-alphaHomo sapiens (human)
plasma membraneHeat shock protein HSP 90-alphaHomo sapiens (human)
neuronal cell bodyHeat shock protein HSP 90-alphaHomo sapiens (human)
perinuclear region of cytoplasmHeat shock protein HSP 90-alphaHomo sapiens (human)
myelin sheathHeat shock protein HSP 90-alphaHomo sapiens (human)
cytosolHeat shock protein HSP 90-alphaHomo sapiens (human)
nucleusHeat shock protein HSP 90-alphaHomo sapiens (human)
extracellular regionEndoplasminHomo sapiens (human)
nucleusEndoplasminHomo sapiens (human)
endoplasmic reticulumEndoplasminHomo sapiens (human)
endoplasmic reticulum lumenEndoplasminHomo sapiens (human)
endoplasmic reticulum membraneEndoplasminHomo sapiens (human)
smooth endoplasmic reticulumEndoplasminHomo sapiens (human)
cytosolEndoplasminHomo sapiens (human)
focal adhesionEndoplasminHomo sapiens (human)
membraneEndoplasminHomo sapiens (human)
midbodyEndoplasminHomo sapiens (human)
sarcoplasmic reticulum lumenEndoplasminHomo sapiens (human)
melanosomeEndoplasminHomo sapiens (human)
perinuclear region of cytoplasmEndoplasminHomo sapiens (human)
collagen-containing extracellular matrixEndoplasminHomo sapiens (human)
extracellular exosomeEndoplasminHomo sapiens (human)
endocytic vesicle lumenEndoplasminHomo sapiens (human)
sperm plasma membraneEndoplasminHomo sapiens (human)
protein-containing complexEndoplasminHomo sapiens (human)
endoplasmic reticulum chaperone complexEndoplasminHomo sapiens (human)
endoplasmic reticulumEndoplasminHomo sapiens (human)
perinuclear region of cytoplasmEndoplasminHomo sapiens (human)
nuclear envelopeRibonucleoside-diphosphate reductase large subunitHomo sapiens (human)
mitochondrionRibonucleoside-diphosphate reductase large subunitHomo sapiens (human)
cytosolRibonucleoside-diphosphate reductase large subunitHomo sapiens (human)
ribonucleoside-diphosphate reductase complexRibonucleoside-diphosphate reductase large subunitHomo sapiens (human)
cell projectionRibonucleoside-diphosphate reductase large subunitHomo sapiens (human)
neuronal cell bodyRibonucleoside-diphosphate reductase large subunitHomo sapiens (human)
nucleusRibonucleoside-diphosphate reductase subunit M2Homo sapiens (human)
cytosolRibonucleoside-diphosphate reductase subunit M2Homo sapiens (human)
ribonucleoside-diphosphate reductase complexRibonucleoside-diphosphate reductase subunit M2Homo sapiens (human)
cytosolRibonucleoside-diphosphate reductase subunit M2Homo sapiens (human)
nucleoplasmRibonucleoside-diphosphate reductase subunit M2 BHomo sapiens (human)
mitochondrionRibonucleoside-diphosphate reductase subunit M2 BHomo sapiens (human)
cytosolRibonucleoside-diphosphate reductase subunit M2 BHomo sapiens (human)
ribonucleoside-diphosphate reductase complexRibonucleoside-diphosphate reductase subunit M2 BHomo sapiens (human)
cytosolRibonucleoside-diphosphate reductase subunit M2 BHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (28)

Assay IDTitleYearJournalArticle
AID31885Binding affinity to adenosine A1 receptor in rat brain membranes by measuring displacement of specific [3H]PIA as radioligand.1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
Search for new purine- and ribose-modified adenosine analogues as selective agonists and antagonists at adenosine receptors.
AID300104Antimalarial activity against chloroquine, pyrimethamine and cycloguanil-resistant Plasmodium falciparum VS1 after 24 hrs2007Bioorganic & medicinal chemistry, Aug-15, Volume: 15, Issue:16
Anti-malarial activity of N6-modified purine analogues.
AID595466Antiproliferative activity against doxorubicin-sensitive human K562 cells after 72 hrs by MTS assay2011European journal of medicinal chemistry, May, Volume: 46, Issue:5
Synthesis and biological activity of novel N6-substituted and 2,N6-disubstituted adenine ribo- and 3'-C-methyl-ribonucleosides as antitumor agents.
AID595461Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay2011European journal of medicinal chemistry, May, Volume: 46, Issue:5
Synthesis and biological activity of novel N6-substituted and 2,N6-disubstituted adenine ribo- and 3'-C-methyl-ribonucleosides as antitumor agents.
AID595465Inhibition of human recombinant ribonucleotide reductase p53R2/M1 expressed in Escherichia coli BL21 (DE3) after 30 mins by [3H]CDP reduction method2011European journal of medicinal chemistry, May, Volume: 46, Issue:5
Synthesis and biological activity of novel N6-substituted and 2,N6-disubstituted adenine ribo- and 3'-C-methyl-ribonucleosides as antitumor agents.
AID25507HPLC capacity factor (k')1985Journal of medicinal chemistry, Nov, Volume: 28, Issue:11
Dog coronary artery adenosine receptor: structure of the N6-alkyl subregion.
AID300102Antimalarial activity against drug-sensitive Plasmodium falciparum 3D7 after 24 hrs2007Bioorganic & medicinal chemistry, Aug-15, Volume: 15, Issue:16
Anti-malarial activity of N6-modified purine analogues.
AID1694546Displacement of FITC-geldanamycin from GRP94 (unknown origin) after 24 hrs by fluorescence polarization assay2021ACS medicinal chemistry letters, Mar-11, Volume: 12, Issue:3
Biological Evaluation of 5'-(
AID1694549Displacement of FITC-geldanamycin from HSP90alpha (unknown origin) at 50 uM after 24 hrs by fluorescence polarization assay relative to control2021ACS medicinal chemistry letters, Mar-11, Volume: 12, Issue:3
Biological Evaluation of 5'-(
AID228918Molar potency ratio was evaluated1985Journal of medicinal chemistry, Nov, Volume: 28, Issue:11
Dog coronary artery adenosine receptor: structure of the N6-alkyl subregion.
AID33337Binding affinity determined by displacement of specific binding of [125I]N-(4-amino-3-iodophenethyl)-adenosine in membranes of CHO cells stably transfected with the rat adenosine A3 receptor1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
Search for new purine- and ribose-modified adenosine analogues as selective agonists and antagonists at adenosine receptors.
AID300105Cytotoxicity against human KB cells2007Bioorganic & medicinal chemistry, Aug-15, Volume: 15, Issue:16
Anti-malarial activity of N6-modified purine analogues.
AID300106Selectivity index, ratio of CC50 for human KB cells to IC50 for Plasmodium falciparum 3D72007Bioorganic & medicinal chemistry, Aug-15, Volume: 15, Issue:16
Anti-malarial activity of N6-modified purine analogues.
AID1694547Displacement of FITC-geldanamycin from HSP90alpha (unknown origin) after 24 hrs by fluorescence polarization assay2021ACS medicinal chemistry letters, Mar-11, Volume: 12, Issue:3
Biological Evaluation of 5'-(
AID521783Antiviral activity against Poliovirus G64S infected in HeLaS3 cells at 2 mM after 6 hrs2008Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3
Lethal mutagenesis of picornaviruses with N-6-modified purine nucleoside analogues.
AID595464Inhibition of human recombinant ribonucleotide reductase M2/M1 expressed in Escherichia coli BL21 (DE3) after 30 mins by [3H]CDP reduction method2011European journal of medicinal chemistry, May, Volume: 46, Issue:5
Synthesis and biological activity of novel N6-substituted and 2,N6-disubstituted adenine ribo- and 3'-C-methyl-ribonucleosides as antitumor agents.
AID595459Antiproliferative activity against human HeLa cells after 72 hrs by MTS assay2011European journal of medicinal chemistry, May, Volume: 46, Issue:5
Synthesis and biological activity of novel N6-substituted and 2,N6-disubstituted adenine ribo- and 3'-C-methyl-ribonucleosides as antitumor agents.
AID595460Antiproliferative activity against human K562 cells after 72 hrs by MTS assay2011European journal of medicinal chemistry, May, Volume: 46, Issue:5
Synthesis and biological activity of novel N6-substituted and 2,N6-disubstituted adenine ribo- and 3'-C-methyl-ribonucleosides as antitumor agents.
AID521786Antiviral activity against Coxsackievirus infected in compound pre-treated HeLaS3 cells assessed as reduction in viral titer at 0.5 mM after 6 hrs relative to control2008Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3
Lethal mutagenesis of picornaviruses with N-6-modified purine nucleoside analogues.
AID521785Antiviral activity against Poliovirus infected in compound pre-treated HeLaS3 cells assessed as reduction in viral titer at 0.5 mM after 6 hrs relative to control2008Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3
Lethal mutagenesis of picornaviruses with N-6-modified purine nucleoside analogues.
AID595462Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay2011European journal of medicinal chemistry, May, Volume: 46, Issue:5
Synthesis and biological activity of novel N6-substituted and 2,N6-disubstituted adenine ribo- and 3'-C-methyl-ribonucleosides as antitumor agents.
AID595463Antiproliferative activity against human Caco2 cells after 72 hrs by MTS assay2011European journal of medicinal chemistry, May, Volume: 46, Issue:5
Synthesis and biological activity of novel N6-substituted and 2,N6-disubstituted adenine ribo- and 3'-C-methyl-ribonucleosides as antitumor agents.
AID300107Selectivity index, ratio of CC50 for human KB cells to IC50 for Plasmodium falciparum K12007Bioorganic & medicinal chemistry, Aug-15, Volume: 15, Issue:16
Anti-malarial activity of N6-modified purine analogues.
AID521781Cytotoxicity against human HeLaS3 cells assessed cell viability at 0.05 after 24 hrs by Alamar blue assay2008Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3
Lethal mutagenesis of picornaviruses with N-6-modified purine nucleoside analogues.
AID1694548Displacement of FITC-geldanamycin from GRP94 (unknown origin) at 50 uM after 24 hrs by fluorescence polarization assay relative to control2021ACS medicinal chemistry letters, Mar-11, Volume: 12, Issue:3
Biological Evaluation of 5'-(
AID33792Binding affinity to adenosine A2A receptor in rat striatal membranes by measuring displacement of specific [3H]-CGS- 21680 as radioligand1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
Search for new purine- and ribose-modified adenosine analogues as selective agonists and antagonists at adenosine receptors.
AID300103Antimalarial activity against chloroquine,pyrimethamine-resistant Plasmodium falciparum K1 after 24 hrs2007Bioorganic & medicinal chemistry, Aug-15, Volume: 15, Issue:16
Anti-malarial activity of N6-modified purine analogues.
AID300108Selectivity index, ratio of CC50 for human KB cells to IC50 for Plasmodium falciparum VS12007Bioorganic & medicinal chemistry, Aug-15, Volume: 15, Issue:16
Anti-malarial activity of N6-modified purine analogues.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (25.00)18.7374
1990's1 (12.50)18.2507
2000's3 (37.50)29.6817
2010's1 (12.50)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
9-xylosyladenine
9-xylosyladenine: RN given refers to cpd with unspecified isomeric designation; structure in first source		1.9810purine nucleoside
3-deazaadenosine
[no description available]		1.9810
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		2.0310aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
pyrimethamine
Maloprim: contains above 2 cpds		2.0310aminopyrimidine;
monochlorobenzenes		antimalarial;
antiprotozoal drug;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor
tubercidin
Tubercidin: An antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic acids.. tubercidin : An N-glycosylpyrrolopyrimidine that is adenosine in which the in the 5-membered ring that is not attached to the ribose moiety is replaced by a carbon. Tubercidin is produced in the culture broth of Streptomyces tubericidus.		1.9810antibiotic antifungal agent;
N-glycosylpyrrolopyrimidine;
ribonucleoside		antimetabolite;
antineoplastic agent;
bacterial metabolite
2-chloroadenosine
5-chloroformycin A: structure given in first source		2.4420purine nucleoside
podophyllotoxin
Podophyllum: A genus of poisonous American herbs, family BERBERIDACEAE. The roots yield PODOPHYLLOTOXIN and other pharmacologically important agents. The plant was formerly used as a cholagogue and cathartic. It is different from the European mandrake, MANDRAGORA.		2.0310furonaphthodioxole;
lignan;
organic heterotetracyclic compound		antimitotic;
antineoplastic agent;
keratolytic drug;
microtubule-destabilising agent;
plant metabolite;
tubulin modulator
2'-deoxyadenosine
2'-deoxyformycin A: RN not in Chemline 9/85; RN and structure given in first source		1.9810purine 2'-deoxyribonucleoside;
purines 2'-deoxy-D-ribonucleoside		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
1-octen-3-ol
1-octen-3-ol: main flavor component of mushrooms; RN given refers to cpd without isomeric designation; bait for insect vectors (tsetse, sandflies, mosquitoes). oct-1-en-3-ol : An alkenyl alcohol with a structure based on a C8 unbranched chain with the hydroxy group at C-2 and unsaturation at C-1-C-2. It is a major volatile compound present in many mushrooms and fungi.		2.0410alkenyl alcohol;
medium-chain fatty alcohol		antimicrobial agent;
fungal metabolite;
insect attractant;
volatile oil component
6-hydroxyadenosine
[no description available]		2.9340
cladribine
[no description available]		1.9810organochlorine compound;
purine 2'-deoxyribonucleoside		antineoplastic agent;
immunosuppressive agent
hyaluronoglucosaminidase
kinetin riboside: preferentially induces apoptosis by modulating Bcl-2 family proteins and caspase-3 in cancer cells; structure in first source		1.9810purine nucleoside
vidarabine
adenine arabinoside : A purine nucleoside in which adenine is attached to arabinofuranose via a beta-N(9)-glycosidic bond.		1.9810beta-D-arabinoside;
purine nucleoside		antineoplastic agent;
bacterial metabolite;
nucleoside antibiotic
6-n-hydroxylaminopurine
N(6)-hydroxyadenine : A member of the class of 6-aminopurinnes that is adenine in which one of the exocyclic amino hydrogens is replaced by a hydroxy group.		2.03106-aminopurines;
hydroxylamines;
nucleobase analogue		mutagen;
teratogenic agent
3-deazaadenosine
3-deazaadenosine: RN given refers to parent cpd.		1.9810
adenosine
quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit		8.0950adenosines;
purines D-ribonucleoside		analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent
aristeromycin
aristeromycin: RN given refers to (1R-(1alpha,2alpha,3beta,5alpha)-isomer		1.9810
metrifudil
[no description available]		1.9810
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		1.95101,2,3-triazole
nebularine
nebularine: structure. nebularine : A purine ribonucleoside that is 9H-purine attached to a beta-D-ribofuranosyl residue at position 9 via a glycosidic (N-glycosyl) linkage.		1.9610purine ribonucleoside;
purines D-ribonucleoside		fungal metabolite
n(6)-benzyladenosine
N(6)-benzyladenosine: RN given refers to parent cpd		1.9810
6-chloropurine riboside
[no description available]		1.9610
phenylisopropyladenosine
[no description available]		1.9610aromatic amine;
benzenes;
hydrocarbyladenosine;
purine nucleoside;
secondary amino compound		adenosine A1 receptor agonist;
neuroprotective agent
8-bromoadenosine
[no description available]		1.9810purine nucleoside
8-aminoadenosine
[no description available]		1.9810
n-allyladenosine
[no description available]		1.9610purine nucleoside
6-methylpurine riboside
[no description available]		1.9610
adenosine-5'-carboxylic acid
[no description available]		2.3110purine nucleoside
adenosine 5'-carboxamide
adenosine 5'-carboxamide: structure		2.3110
5'-n-methylcarboxamideadenosine
5'-N-methylcarboxamideadenosine: RN given refers to (beta-D)-isomer		2.3110
n(6)-methoxyadenine
[no description available]		2.0310
2-amino-n(6)-hydroxyadenine
2-amino-N(6)-hydroxyadenine: mutagen & bacterial growth inhibitor; structure in first source. 2-amino-6-hydroxyaminopurine : A 2,6-diaminopurine that is the N(6)-hydroxy derivative of 2,6-diamino-3H-purine.		2.03102,6-diaminopurines;
hydroxylamines;
nucleobase analogue		mutagen;
teratogenic agent
n(6)-methoxyadenosine
[no description available]		2.7430
n-methyladenosine
N-methyladenosine: is a inhibitor of cell differentiation. N(6)-methyladenosine : A methyladenosine compound with one methyl group attached to N(6) of the adenine nucleobase.		2.4220methyladenosine
2'-o-methyladenosine
cordysinin B : A member of the class of adenosines that is adenosine in which the hydroxy group at position 2' is replaced by a methoxy group. It has been isolated from the mycelia of Cordyceps sinensis.		1.9810adenosines;
ether		fungal metabolite
n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine
N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine: structure given in first source; a selective A(3) adenosine receptor agonist. 3-iodobenzyl-5'-N-methylcarboxamidoadenosine : A derivative of adenosine in which the 5'-hydroxymethyl group is replaced by N-ethylcarboxamido and one of the hydrogens of the exocyclic amino function is substituted by a 3-iodobenzyl group.		1.9810adenosines;
monocarboxylic acid amide;
organoiodine compound		adenosine A3 receptor agonist
6-methoxypurine arabinoside
[no description available]		1.9610
5'-noraristeromycin
5'-noraristeromycin: structure given in first source		1.9810
2-hexynyladenosine-5'-n-ethylcarboxamide
2-hexynyladenosine-5'-N-ethylcarboxamide: adenosine receptor agonist		1.9810
5'-deoxyadenosine
5'-deoxyadenosine: main heading DEOXYADENOSINE refers to the 3' cpd. 5'-deoxyadenosine : A 5'-deoxyribonucleoside compound having adenosine as the nucleobase.		1.98105'-deoxyribonucleoside;
adenosines		Escherichia coli metabolite;
human metabolite;
mouse metabolite
n(6),n(6)-dimethyladenosine
N(6),N(6)-dimethyladenosine : A methyladenosine compound with two methyl groups attached to N(6) of the adenine nucleobase.		1.9610hydrocarbyladenosine
adenosine 5'-phosphoramidate
adenosine 5'-phosphoramidate : The phosphoramadite analogue of AMP.		2.3110organic phosphoramidateMycoplasma genitalium metabolite
adenosine-5'-(n-ethylcarboxamide)
Adenosine-5'-(N-ethylcarboxamide): A stable adenosine A1 and A2 receptor agonist. Experimentally, it inhibits cAMP and cGMP phosphodiesterase activity.. N-ethyl-5'-carboxamidoadenosine : A derivative of adenosine in which the 5'-hydroxymethyl group is replaced by an N-ethylcarboxamido group.		2.4420adenosines;
monocarboxylic acid amide		adenosine A1 receptor agonist;
adenosine A2A receptor agonist;
antineoplastic agent;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
vasodilator agent
3'-c-methyladenosine
3'-C-methyladenosine: structure in first source		2.4220
fludarabine
[no description available]		1.9810purine nucleoside
n(6)-cyclopentyladenosine
[no description available]		1.9610
adenosine-5'-(N-propyl)carboxamide
adenosine-5'-(N-propyl)carboxamide : A monocarboxylic acid amide that is the propyl amide of adenosine 5'-carboxylic acid.		2.3110adenosines;
monocarboxylic acid amide
n-(1-methyl-2-phenylethyl)adenosine, (s)-isomer
[no description available]		1.9610
5'-amino-5'-deoxyadenosine
[no description available]		2.3110
n(6)-cyclohexyladenosine
N(6)-cyclohexyladenosine: structure given in first source; receptors, purinergic P1 agonist		1.9610
n(6)-(2,2-diphenylethyl)adenosine
N(6)-(2,2-diphenylethyl)adenosine: adenosine receptor agonist; structure given in first source		2.3110
n-cyclopropyl adenosine-5'-carboxamide
[no description available]		2.3110
ConditionIndicatedRelationship StrengthStudiesTrials