Compounds > sufotidine
Page last updated: 2024-11-06

sufotidine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Cross-References

ID SourceID
PubMed CID71763
CHEMBL ID2105496
CHEBI ID177728
SCHEMBL ID757
MeSH IDM0172011

Synonyms (27)

Synonym
CHEBI:177728
2-methyl-5-(methylsulonylmethyl)-n-[3-[3-(piperidin-1-ylmethyl)phenoxy]propyl]-1,2,4-triazol-3-amine
D05939
80343-63-1
sufotidine (usan/inn)
sufotidine
L003829
2-methyl-5-(methylsulfonylmethyl)-n-[3-[3-(piperidin-1-ylmethyl)phenoxy]propyl]-1,2,4-triazol-3-amine
56b0591y76 ,
sufotidine [usan:inn:ban]
sufotidinum
sufotidina [spanish]
unii-56b0591y76
sufotidina
ah 25352x
1h-1,2,4-triazol-5-amine, 1-methyl-3-((methylsulfonyl)methyl)-n-(3-(3-(1-piperidinylmethyl)phenoxy)propyl)-
sufotidinum [latin]
1-(m-(3-((1-methyl-3-((methylsulfonyl)methyl)-1h-1,2,4-triazol-5-yl)amino)propoxy)benzyl)piperidine
sufotidine [inn]
sufotidine [usan]
ah-25352x
CHEMBL2105496
SCHEMBL757
DTXSID50230254
JEYKZWRXDALMNG-UHFFFAOYSA-N
1-methyl-3-methylsulphonylmethyl-n-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-1h-1,2,4-triazole-5-amine
Q27261396

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" On day 1 and 15 of dosing with each regimen, each subject's 24-h ambulatory intragastric acidity was measured by radiotelemetry and 24-h plasma gastrin profiles were derived from hourly venous blood samples."( The effects of 15 days of dosing with placebo, sufotidine 600 mg nocte or sufotidine 600 mg twice daily upon 24-hour intragastric acidity and 24-hour plasma gastrin.
Holmfield, JH; Johnston, D; Primrose, JN; Rogers, MJ, 1990)		0.54
" In neither study were there any significant differences between the acid secretory dose-response curves to histamine in control and test animals."( Chronic administration of H2-antagonists does not alter gastric secretory responses to histamine, or the antisecretory activity of sufotidine.
Humphray, JM; Reeves, JJ; Stables, R, 1990)		0.48
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
piperidines
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (12.50)18.7374
1990's7 (87.50)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials5 (62.50%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other3 (37.50%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
histamine
[no description available]		7.3920aralkylamino compound;
imidazoles		human metabolite;
mouse metabolite;
neurotransmitter
roxatidine acetate
roxatidine acetate: structure given in first source		1.9910piperidines
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		6.25851,2,3-triazole
ranitidine
Ranitidine: A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.. ranitidine : A member of the class of furans used to treat peptic ulcer disease (PUD) and gastroesophageal reflux disease.		4.3222C-nitro compound;
furans;
organic sulfide;
tertiary amino compound		anti-ulcer drug;
drug allergen;
environmental contaminant;
H2-receptor antagonist;
xenobiotic
pibutidine hydrochloride
IT 066: structure in first source. pibutidine hydrochloride : The hydrochloride salt of pibutidine. It is a H2 receptor antagonist which was developed for the treatment of peptic ulcers and duodenal ulcers. It was in phase III clinical trials in Japan (now discontinued).		1.9910hydrochlorideanti-ulcer drug;
H2-receptor antagonist
gastrins
Gastrins: A family of gastrointestinal peptide hormones that excite the secretion of GASTRIC JUICE. They may also occur in the central nervous system where they are presumed to be neurotransmitters.		5.6454
piperidines
Piperidines: A family of hexahydropyridines.		6.2585
ConditionIndicatedRelationship StrengthStudiesTrials
Curling Ulcer
Acute stress DUODENAL ULCER, usually observed in patients with extensive third-degree burns.		03.3611
Duodenal Ulcer
A PEPTIC ULCER located in the DUODENUM.		08.3611
Esophagitis
INFLAMMATION, acute or chronic, of the ESOPHAGUS caused by BACTERIA, chemicals, or TRAUMA.		03.3611