Compounds > triazoles
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triazoles and Carcinoma, Non-Small Cell Lung

triazoles has been researched along with Carcinoma, Non-Small Cell Lung in 68 studies

Research

Studies (68)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (1.47)18.2507
2000's5 (7.35)29.6817
2010's50 (73.53)24.3611
2020's12 (17.65)2.80

Authors

AuthorsStudies
Cha, SI; Cho, S; Choi, JE; Choi, SH; Do, SK; Hong, MJ; Jheon, S; Kang, HG; Kim, CH; Lee, EB; Lee, J; Lee, JH; Lee, SY; Lee, WK; Lee, YH; Park, JY; Seo, H; Yoo, SS1
Biegański, P; Godel, M; Kawano, DF; Kopecka, J; Kowalski, K; Riganti, C1
Chen, L; Chen, W; Li, L1
Chen, M; Dong, J; Gao, Y; Liu, W; Wang, T; Zhu, D1
Biegański, P; Dmitrieva, E; Godel, M; Israel, N; Kopecka, J; Kovalski, E; Kowalski, K; Lang, H; Riganti, C; Trzybiński, D; Vrček, V; Woźniak, K1
Castellano, GM; Garbuzenko, OB; Malhotra, J; Minko, T; Pine, SR; Sabaawy, HE; Zeeshan, S1
Beattie, D; Cadogan, EB; Cairns, J; Davies, BR; Dean, E; Farrington, PM; Fawell, SE; Finlay, MRV; Fok, JHL; Follia, V; Goldberg, FW; Hollingsworth, SJ; James, N; Karmokar, A; Lamont, GM; Ling, S; Nikkilä, J; O'Connor, LO; O'Connor, MJ; Ramos-Montoya, A; Smith, A; Vazquez-Chantada, M; Wijnhoven, PWG; Willis, SE; Wilson, J1
Arunrungvichian, K; Doungchawee, J; Pongrakhananon, V; Pothongsrisit, S; Vajragupta, O; Witayateeraporn, W1
Byers, LA; Cardnell, RJ; Diao, L; Fowlkes, NW; Fradette, JJ; Gibbons, DL; Gibson, L; Konen, JM; Kovacs, JJ; Ochieng, JK; Padhye, A; Peng, DH; Rodriguez, BL; Wang, J1
Chen, J; Cheng, Z; Luo, J; Meng, Y; Sun, T; Wang, X; Xia, B; Zhang, Z; Zhou, X1
Banerjee, T; Gross, RA; Naz, S; Santra, S; Totsingan, F; Woody, K1
Hu, X; Shi, L; Wang, Z; Xie, C; Xiong, Y1
Chen, C; Chen, W; Guo, L; Ju, R; Li, J; Shi, J; Sun, F; Ye, C; Zhang, D; Zhu, L1
Bajić, M; Bistrović, A; Grbčić, P; Harej, A; Koštrun, S; Krstulović, L; Pavelić, SK; Raić-Malić, S; Sedić, M1
Dasu, A; Even, AJG; Lambin, P; Lindblom, E; Toma-Dasu, I; Uhrdin, J; Ureba, A; van Elmpt, W; Wersäll, P1
Chiu, CC; Fang, K; Hsieh, CH; Liu, CY; Wang, JP; Yao, CF1
Bistrović, A; Grbčić, P; Harej, A; Koštrun, S; Kraljević-Pavelić, S; Makuc, D; Plavec, J; Raić-Malić, S; Sedić, M1
Cheng, Z; Gao, Z; Li, P; Ni, P; Sun, G; Wang, X; Yuan, T; Zhou, X1
Burns, TF; Chatterjee, S; Goldstein, LA; Han, J; Hou, W; Rabinowich, H1
Handoko, L; Hon, CC; Ito, T; Jeyamohan, P; Kaczkowski, B; Kimura, H; Lizio, M; Matsuda, T; Minoda, A; Sakamoto, K; Sato, Y; Umehara, T; Wakamori, M; Yokoyama, S1
Adeegbe, DO; Bass, AJ; Bowden, M; Bradner, JE; Chen, H; Diehl, JA; Dolgalev, I; Freeman, GJ; Gao, P; Grondine, M; Hammerman, PS; Hattersley, MM; Ivanova, EV; Li, S; Liu, S; Quinn, MM; Rustgi, AK; Tsirigos, A; Vlahos, R; Wong, KK; Zhou, CW1
Fujino, N; Fujishima, F; Ichinose, M; Inoue, A; Itakura, K; Kyogoku, Y; Miyauchi, E; Okada, Y; Okazaki, T; Okutomo, K; Saito, R; Sugiura, H; Tsukita, Y; Yamada, M1
Banerjee, T; Darji, S; Fletcher, C; Gerasimchuk, NN; Higginbotham, R; Kallu, J; Santra, S; Sulthana, S1
Kurihara, E; Namba, K; Ogoshi, Y; Okazaki, M; Sato, H; Shien, K; Shien, T; Soh, J; Suzawa, K; Takahashi, Y; Takeda, T; Tomida, S; Torigoe, H; Toyooka, S; Yamamoto, H; Yoshioka, T1
Liu, JW; Xiong, ZQ; Yang, C; Zhao, M; Zhu, ZC1
Boran, A; Chen, Y; Gallo, J; Goldfarb, J; Hu, Y; Iyengar, R; Jayaraman, G; Li, L; Mariottini, C; Tavassoly, I; Tolentino, RE; Zhao, S1
Dosaka-Akita, H; Furuta, M; Kikuchi, E; Kikuchi, H; Kikuchi, J; Kinoshita, I; Konno, S; Maeda, M; Sakakibara-Konishi, J; Shoji, T; Suzuki, M; Takashima, Y1
Akca, H; Alvur, O; Baygu, Y; Gok, Y; Kabay, N; Tokgun, O1
Acquaviva, J; Bates, RC; Camidge, DR; Doebele, RC; El-Hariry, I; Friedland, JC; He, S; Jiang, Q; Jimenez, JP; Lovly, CM; Morris, SW; Proia, DA; Sang, J; Sequeira, M; Shaw, AT; Smith, DL; Xue, L; Zhang, C1
Belani, CP; Bonomi, P; Brahmer, J; Chen, LC; El-Hariry, I; Goldman, J; Guo, W; Harper, H; Horn, L; Huberman, M; Koczywas, M; Paschold, E; Ramalingam, S; Salgia, R; Sandler, A; Sequist, LV; Shapiro, GI; Socinski, MA; Teofilovici, F; Vukovic, V; Webb, T; West, H; Wong, KK1
Brans, B; De Ruysscher, D; Eriksson, J; Hoebers, F; Lambin, P; Mottaghy, FM; Öllers, MC; Reymen, B; Sharifi, H; Troost, EG; van Baardwijk, A; van Elmpt, W; Wanders, R; Wierts, R; Windhorst, B; Zegers, CM1
Akbay, E; Bradner, JE; Carretero, J; Chen, Z; Cheng, KA; Cohoon, TJ; Gao, Y; Kikuchi, E; Kimmelman, AC; Kung, AL; Qi, J; Shimamura, T; Soucheray, M; Tchaicha, JH; Wong, KK1
Yaqub, F1
Pillai, RN; Ramalingam, SS1
Acquaviva, J; Bates, RC; He, S; Proia, DA; Sang, J; Sequeira, M; Smith, DL; Zhang, C1
Han, X; Shi, Y; Wang, J; Wang, S; Yao, J1
Chien, W; Ding, L; E-Ling, GL; Hattori, N; Kauffman, M; Koeffler, HP; Lim, SL; Nakamaki, T; Shacham, S; Sudo, M; Sun, H; Sun, Q1
Ebi, H; Kita, K; Matsumoto, K; Nanjo, S; Takeuchi, S; Tanimoto, A; Yamada, T; Yano, S1
Acquaviva, J; Bates, RC; Jimenez, JP; Proia, DA; Sang, J; Sequeira, M; Smith, DL; Zhang, C1
De Ruysscher, D; Eriksson, J; Even, AJ; Hoebers, FJ; Houben, RM; Lambin, P; Mottaghy, FM; Ollers, MC; Reymen, B; Troost, EG; van Elmpt, W; Windhorst, AD; Zegers, CM1
Brown, MP; Singhal, N; Vatandoust, S1
Biemans, R; Dubois, LJ; Hart, CP; Lambin, P; Lieuwes, NG; Peeters, SG; Sun, JD; van Elmpt, W; van Stiphout, RG; Windhorst, AD; Yaromina, A; Zegers, CM1
Andric, Z; Bondarenko, I; Ceric, T; Ciuleanu, T; Felip, E; Fennell, D; Goss, G; Hirsh, V; Khuri, F; Komov, D; Ramalingam, S; Rosell, R; Salgia, R; Samarzija, M; Schmid-Bindert, G; Shapiro, G; Sheldon, E; Spicer, J; Teofilovici, F; Vukovic, V; Wehler, T; Zaric, B1
Asahina, H; Beauchamp, EM; Buczkowski, KA; Hammerman, PS; Li, YY; Meyerson, M; Terai, H; Wong, KK; Xu, C; Zhang, Y1
Das, M; Dingemans, AC; Even, AJG; Lambin, P; Mottaghy, FM; Oellers, M; Reymen, B; Troost, EGC; van Elmpt, W; Wildberger, JE; Zegers, CML1
Cai, H; Huang, X; Huang, Y; Jiang, B; Jiang, J; Shen, H; Sun, Y; Wu, X; Xu, J; Xu, S; Yao, H; Zhang, P1
Diao, L; Komaki, R; Lin, SH; Liu, H; Potter, A; Proia, DA; Qiao, Y; Tailor, R; Wang, J; Wang, Y; Zhang, J1
Bogman, K; Bordogna, W; Cleary, Y; Dall, G; De Petris, L; Guerini, E; Martin-Facklam, M; Morcos, PN; Phipps, A; Viteri, S; Yu, L1
Gelato, KA; Haendler, B; Klingbeil, O; Lejeune, P; Lesche, R1
Banerjee, T; Heckert, B; Kallu, J; Naz, S; Santra, S; Shelby, T; Sulthana, S; Vuppala, SR; Yambem, O1
Geng, Y; Lin, Z; Mei, H; Wang, J; Wang, Y; Wu, G; Yin, Z; Zhang, T1
Barnett, J; Cuthbertson, A; Morrison, MS; Ricketts, SA; Tessier, J; Wedge, SR1
Ballman, KV; Bot, B; Buckner, JC; DeMatteo, RP; Hillman, SL; Mandrekar, SJ; Nelson, H; Perez, EA; Sargent, DJ1
Blackman, RK; Foley, KP; He, S; Koya, K; Liu, Y; Proia, DA; Sang, J; Sequeira, M; Smith, DL; Wada, Y; Ye, S; Zhang, C; Zhou, D1
Fandzloch, M; Popławska, B; Sitkowski, J; Łakomska, I1
Barsoum, J; Borgman, CL; Carey, CD; Carretero, J; Chen, L; Foley, KP; Inoue, T; Jimenez, JP; Li, D; Li, YC; Meyerson, M; Perera, SA; Rodig, SJ; Sang, J; Shapiro, GI; Shimamura, T; Sinha, P; Wong, KK; Ying, W1
Bill, A; Famulok, M; Hannam, JS; Heukamp, LC; König, K; Schmitz, A1
Abe, K; Kondo, T; Miki, Y; Nagasaki, S; Niikawa, H; Sasano, H; Suzuki, S; Verma, MK1
Chen, Z; Li, Z; Liao, M; Lu, S; Niu, X; Shen, L; Shen, S; Yu, Y1
Acquaviva, J; Friedland, JC; He, S; Proia, DA; Sang, J; Sequeira, M; Smith, DL; Wada, Y; Zhang, C1
Hosoya, T; Imai, S; Kuzumaki, N; Morita, H; Nagasawa, A; Narita, M; Okada, Y; Okano, H; Okano, HJ; Suzuki, A; Suzuki, T; Yamamizu, K; Yamashita, JK1
Zhang, HJ; Zhang, L; Zhang, XT1
Digklia, A; Voutsadakis, IA1
Dubinett, SM; Fishbein, MC; Garban, HJ; Goodglick, L; Marquez-Garban, DC; Pietras, RJ; Weinberg, OK1
Cai, LF; Erdjument-Bromage, H; Kaufman, AJ; Pandolfi, PP; Scaglioni, PP; Singh, B; Tempst, P; Teruya-Feldstein, J; Yung, TM1
Assaraf, YG; Bram, EE; Grimberg, M; Ifergan, I; Lemke, K; Skladanowski, A1
Adjei, AA; Bauman, MD; Bernath, AM; Fitch, TR; Graham, DL; Hauge, MD; Hillman, SL; Jett, JR; Johnson, EA; Kugler, JW; Mandrekar, SJ; Marks, RS; Moore, DF; Perez, EA; Soori, GS; Windschitl, HE; Wos, EJ1
Shibamoto, Y1

Reviews

3 review(s) available for triazoles and Carcinoma, Non-Small Cell Lung

ArticleYear
Heat shock protein 90 inhibitors in non-small-cell lung cancer.
    Current opinion in oncology, 2014, Volume: 26, Issue:2

    Topics: Benzamides; Benzoquinones; Carcinoma, Non-Small-Cell Lung; HSP90 Heat-Shock Proteins; Humans; Isoindoles; Isoxazoles; Lactams, Macrocyclic; Lung Neoplasms; Molecular Targeted Therapy; Resorcinols; Treatment Outcome; Triazoles

2014
[Mechanisms of resistance to crizotinib in patients with transforming EML4-ALK fusion gene].
    Zhonghua bing li xue za zhi = Chinese journal of pathology, 2012, Volume: 41, Issue:12

    Topics: Apoptosis; Benzoquinones; Carcinoma, Non-Small-Cell Lung; Crizotinib; Drug Resistance, Neoplasm; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Lung Neoplasms; Mutation; Oncogene Proteins, Fusion; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Triazoles

2012
[Contribution of radiation biology to the development of radiation therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1999, Volume: 26, Issue:9

    Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Dose Fractionation, Radiation; Humans; Imidazoles; Lung Neoplasms; Neoplasms; Nimorazole; Radiation-Sensitizing Agents; Triazoles

1999

Trials

7 trial(s) available for triazoles and Carcinoma, Non-Small Cell Lung

ArticleYear
Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancer.
    Cancer discovery, 2013, Volume: 3, Issue:4

    Topics: Adult; Anaplastic Lymphoma Kinase; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Crizotinib; Drug Resistance, Neoplasm; Female; HSP90 Heat-Shock Proteins; Humans; Lung Neoplasms; Male; Mice; Mice, Nude; Mice, SCID; Pyrazoles; Pyridines; Receptor Protein-Tyrosine Kinases; Triazoles; Tumor Burden; Xenograft Model Antitumor Assays; Young Adult

2013
A multicenter phase II study of ganetespib monotherapy in patients with genotypically defined advanced non-small cell lung cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2013, Jun-01, Volume: 19, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Anaplastic Lymphoma Kinase; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Female; Gene Rearrangement; Genotype; HSP90 Heat-Shock Proteins; Humans; Lung Neoplasms; Male; Middle Aged; Mutation; Neoplasm Staging; Receptor Protein-Tyrosine Kinases; Treatment Outcome; Triazoles

2013
Phase II study evaluating efficacy and safety of everolimus with letrozole for management of advanced (unresectable or metastatic) non-small cell lung cancer after failure of platinum-based treatment: a preliminary analysis of toxicity.
    Cancer chemotherapy and pharmacology, 2015, Volume: 75, Issue:2

    Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Carcinoma, Non-Small-Cell Lung; Everolimus; Female; Humans; Letrozole; Lung Diseases; Lung Neoplasms; Male; Middle Aged; Nitriles; Organoplatinum Compounds; Sirolimus; Smoking; Triazoles

2015
A randomized phase II study of ganetespib, a heat shock protein 90 inhibitor, in combination with docetaxel in second-line therapy of advanced non-small cell lung cancer (GALAXY-1).
    Annals of oncology : official journal of the European Society for Medical Oncology, 2015, Volume: 26, Issue:8

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Disease-Free Survival; Docetaxel; Female; HSP90 Heat-Shock Proteins; Humans; L-Lactate Dehydrogenase; Lung Neoplasms; Male; Middle Aged; Proportional Hazards Models; Proto-Oncogene Proteins p21(ras); Taxoids; Treatment Outcome; Triazoles

2015
Multiparametric imaging of patient and tumour heterogeneity in non-small-cell lung cancer: quantification of tumour hypoxia, metabolism and perfusion.
    European journal of nuclear medicine and molecular imaging, 2016, Volume: 43, Issue:2

    Topics: Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Female; Fluorodeoxyglucose F18; Humans; Lung Neoplasms; Male; Multimodal Imaging; Nitroimidazoles; Oxygen; Oxygen Consumption; Positron-Emission Tomography; Radiopharmaceuticals; Tomography, X-Ray Computed; Triazoles

2016
Clinical Drug-Drug Interactions Through Cytochrome P450 3A (CYP3A) for the Selective ALK Inhibitor Alectinib.
    Clinical pharmacology in drug development, 2017, Volume: 6, Issue:3

    Topics: Adult; Anaplastic Lymphoma Kinase; Carbazoles; Carcinoma, Non-Small-Cell Lung; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Female; Humans; Lung Neoplasms; Male; Midazolam; Middle Aged; Piperidines; Receptor Protein-Tyrosine Kinases; Rifampin; Treatment Outcome; Triazoles; Young Adult

2017
Phase III randomized, double-blind study of maintenance CAI or placebo in patients with advanced non-small cell lung cancer (NSCLC) after completion of initial therapy (NCCTG 97-24-51).
    Lung cancer (Amsterdam, Netherlands), 2008, Volume: 60, Issue:2

    Topics: Aged; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Double-Blind Method; Female; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Male; Middle Aged; Placebos; Quality of Life; Triazoles

2008

Other Studies

58 other study(ies) available for triazoles and Carcinoma, Non-Small Cell Lung

ArticleYear
Epigenetic readers and lung cancer: the rs2427964C>T variant of the bromodomain and extraterminal domain gene BRD3 is associated with poorer survival outcome in NSCLC.
    Molecular oncology, 2022, Volume: 16, Issue:3

    Topics: Azepines; Carcinoma, Non-Small-Cell Lung; Epigenesis, Genetic; Humans; Lung Neoplasms; Transcription Factors; Triazoles

2022
Click ferrocenyl-erlotinib conjugates active against erlotinib-resistant non-small cell lung cancer cells in vitro.
    Bioorganic chemistry, 2022, Volume: 119

    Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; ErbB Receptors; Erlotinib Hydrochloride; Humans; Iron Compounds; Lung Neoplasms; Molecular Structure; Protein Kinase Inhibitors; Structure-Activity Relationship; Triazoles

2022
Use of Modeling and Simulation to Predict the Influence of Triazole Antifungal Agents on the Pharmacokinetics of Crizotinib.
    Clinical pharmacology in drug development, 2022, Volume: 11, Issue:6

    Topics: Antifungal Agents; Carcinoma, Non-Small-Cell Lung; Crizotinib; Fluconazole; Humans; Itraconazole; Lung Neoplasms; Triazoles; Voriconazole

2022
Mubritinib enhanced the inhibiting function of cisplatin in lung cancer by interfering with mitochondrial function.
    Thoracic cancer, 2022, Volume: 13, Issue:10

    Topics: Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cisplatin; Humans; Lung Neoplasms; Mice; Mitochondria; Oxazoles; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Triazoles

2022
Electronic Coupling in 1,2,3-Triazole Bridged Ferrocenes and Its Impact on Reactive Oxygen Species Generation and Deleterious Activity in Cancer Cells.
    Inorganic chemistry, 2022, Jun-27, Volume: 61, Issue:25

    Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Electronics; Humans; Lung Neoplasms; Metallocenes; Reactive Oxygen Species; Triazoles

2022
Inhibition of Mtorc1/2 and DNA-PK via CC-115 Synergizes with Carboplatin and Paclitaxel in Lung Squamous Cell Carcinoma.
    Molecular cancer therapeutics, 2022, 09-06, Volume: 21, Issue:9

    Topics: Animals; Carboplatin; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Line, Tumor; Class I Phosphatidylinositol 3-Kinases; DNA; Humans; Lung; Lung Neoplasms; Mechanistic Target of Rapamycin Complex 1; Mice; Paclitaxel; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyrazines; TOR Serine-Threonine Kinases; Triazoles

2022
AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity.
    Nature communications, 2019, 11-07, Volume: 10, Issue:1

    Topics: A549 Cells; Animals; Antibiotics, Antineoplastic; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; DNA-Activated Protein Kinase; Doxorubicin; Drug Synergism; Genomic Instability; Humans; Lung Neoplasms; Mice; Phthalazines; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Polyethylene Glycols; Protein Kinase Inhibitors; Purines; Pyrans; Radiation Tolerance; Radiotherapy; Triazoles; Xenograft Model Antitumor Assays

2019
α7-Nicotinic acetylcholine receptor antagonist QND7 suppresses non-small cell lung cancer cell proliferation and migration via inhibition of Akt/mTOR signaling.
    Biochemical and biophysical research communications, 2020, 01-22, Volume: 521, Issue:4

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Humans; Inhibitory Concentration 50; Lung Neoplasms; Proto-Oncogene Proteins c-akt; Quinuclidines; Signal Transduction; TOR Serine-Threonine Kinases; Triazoles

2020
Dual Inhibition of MEK and AXL Targets Tumor Cell Heterogeneity and Prevents Resistant Outgrowth Mediated by the Epithelial-to-Mesenchymal Transition in NSCLC.
    Cancer research, 2021, 03-01, Volume: 81, Issue:5

    Topics: A549 Cells; Animals; Antineoplastic Combined Chemotherapy Protocols; Axl Receptor Tyrosine Kinase; Benzimidazoles; Benzocycloheptenes; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Epithelial-Mesenchymal Transition; Humans; Lung Neoplasms; Mice, Inbred Strains; Mitogen-Activated Protein Kinase Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Triazoles; Xenograft Model Antitumor Assays

2021
BET inhibitors combined with chemotherapy synergistically inhibit the growth of NSCLC cells.
    Oncology reports, 2021, Volume: 45, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azepines; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cisplatin; Drug Synergism; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Heterocyclic Compounds, 4 or More Rings; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Paclitaxel; Prognosis; Signal Transduction; Transcription Factors; Triazoles

2021
Therapeutic Efficacy of Lactonic Sophorolipids: Nanoceria-Assisted Combination Therapy of NSCLC using HDAC and Hsp90 Inhibitors.
    Nanotheranostics, 2021, Volume: 5, Issue:4

    Topics: A549 Cells; Animals; Antineoplastic Agents; Antioxidants; Carcinoma, Non-Small-Cell Lung; Cerium; CHO Cells; Combined Modality Therapy; Cricetinae; Cricetulus; Glycolipids; Histone Deacetylase Inhibitors; HSP90 Heat-Shock Proteins; Humans; Lung Neoplasms; Triazoles

2021
BRD4 inhibition promotes TRAIL-induced apoptosis by suppressing the transcriptional activity of NF-κB in NSCLC.
    International journal of medical sciences, 2021, Volume: 18, Issue:14

    Topics: A549 Cells; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azepines; Carcinoma, Non-Small-Cell Lung; Cell Cycle Proteins; Fas-Associated Death Domain Protein; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Lung Neoplasms; NF-kappa B; Recombinant Proteins; TNF-Related Apoptosis-Inducing Ligand; Transcription Factors; Transcriptional Activation; Triazoles

2021
Carboxyamidotriazole Synergizes with Sorafenib to Combat Non-Small Cell Lung Cancer through Inhibition of NANOG and Aggravation of Apoptosis.
    The Journal of pharmacology and experimental therapeutics, 2017, Volume: 362, Issue:2

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Lewis Lung; Carcinoma, Non-Small-Cell Lung; Dose-Response Relationship, Drug; Drug Synergism; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Nanog Homeobox Protein; Niacinamide; Phenylurea Compounds; Sorafenib; Triazoles; Xenograft Model Antitumor Assays

2017
Design, synthesis and biological evaluation of novel benzimidazole amidines as potent multi-target inhibitors for the treatment of non-small cell lung cancer.
    European journal of medicinal chemistry, 2018, Jan-01, Volume: 143

    Topics: Amidines; Antineoplastic Agents; Apoptosis; Benzimidazoles; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Cells, Cultured; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Lung Neoplasms; Models, Molecular; Molecular Structure; Protein Kinase Inhibitors; Protein Kinases; Structure-Activity Relationship; Triazoles

2018
Non-linear conversion of HX4 uptake for automatic segmentation of hypoxic volumes and dose prescription.
    Acta oncologica (Stockholm, Sweden), 2018, Volume: 57, Issue:4

    Topics: Carcinoma, Non-Small-Cell Lung; Fluorine Radioisotopes; Humans; Imidazoles; Lung Neoplasms; Positron-Emission Tomography; Radiopharmaceuticals; Radiotherapy Planning, Computer-Assisted; Triazoles; Tumor Hypoxia

2018
A triazole-conjugated benzoxazone induces reactive oxygen species and promotes autophagic apoptosis in human lung cancer cells.
    Apoptosis : an international journal on programmed cell death, 2018, Volume: 23, Issue:1

    Topics: A549 Cells; Animals; Antineoplastic Agents; Apoptosis; Autophagy; Benzoxazines; Carcinoma, Non-Small-Cell Lung; Caspase 3; Cell Cycle; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 2-Ring; Humans; Injections, Subcutaneous; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Microtubule-Associated Proteins; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; Signal Transduction; Triazoles; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

2018
Small molecule purine and pseudopurine derivatives: synthesis, cytostatic evaluations and investigation of growth inhibitory effect in non-small cell lung cancer A549.
    Journal of enzyme inhibition and medicinal chemistry, 2018, Volume: 33, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Cells, Cultured; Cytostatic Agents; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Lung Neoplasms; Models, Molecular; Molecular Structure; Purines; Small Molecule Libraries; Structure-Activity Relationship; Triazoles

2018
Targeting BRD4 proteins suppresses the growth of NSCLC through downregulation of eIF4E expression.
    Cancer biology & therapy, 2018, 05-04, Volume: 19, Issue:5

    Topics: A549 Cells; Animals; Azepines; Carcinoma, Non-Small-Cell Lung; Cell Cycle Proteins; Cell Line, Tumor; Disease Models, Animal; Down-Regulation; Eukaryotic Initiation Factor-4E; Heterocyclic Compounds, 4 or More Rings; Humans; Lung Neoplasms; Mice; Mice, Nude; Molecular Targeted Therapy; Nuclear Proteins; Random Allocation; Transcription Factors; Transfection; Triazoles; Xenograft Model Antitumor Assays

2018
HSP90 inhibition targets autophagy and induces a CASP9-dependent resistance mechanism in NSCLC.
    Autophagy, 2018, Volume: 14, Issue:6

    Topics: Autophagy; Autophagy-Related Protein 7; Carcinoma, Non-Small-Cell Lung; Caspase 9; Cell Line, Tumor; Cytoprotection; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Stability; HSP90 Heat-Shock Proteins; Humans; Lung Neoplasms; Mutation; Protein Domains; Triazoles; Up-Regulation

2018
JQ1 affects BRD2-dependent and independent transcription regulation without disrupting H4-hyperacetylated chromatin states.
    Epigenetics, 2018, Volume: 13, Issue:4

    Topics: Acetylation; Animals; Azepines; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chromatin; Gene Expression Regulation, Neoplastic; Histones; Humans; Lung Neoplasms; Mice; Models, Molecular; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-myc; Transcription Factors; Transcription Initiation Site; Triazoles

2018
BET Bromodomain Inhibition Cooperates with PD-1 Blockade to Facilitate Antitumor Response in
    Cancer immunology research, 2018, Volume: 6, Issue:10

    Topics: Adoptive Transfer; Animals; Azepines; Carcinoma, Non-Small-Cell Lung; Cytokines; Lung Neoplasms; Mice, Nude; Mice, Transgenic; Mutation; Nuclear Proteins; Programmed Cell Death 1 Receptor; Proto-Oncogene Proteins p21(ras); T-Lymphocytes; Triazoles; Tumor Suppressor Protein p53

2018
Axl kinase drives immune checkpoint and chemokine signalling pathways in lung adenocarcinomas.
    Molecular cancer, 2019, 02-11, Volume: 18, Issue:1

    Topics: Adenocarcinoma of Lung; Antineoplastic Agents; Axl Receptor Tyrosine Kinase; B7-H1 Antigen; Benzocycloheptenes; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cohort Studies; Disease Progression; Epithelial-Mesenchymal Transition; ErbB Receptors; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Oligonucleotide Array Sequence Analysis; Prognosis; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptors, CXCR6; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Triazoles

2019
Nanomedicine-Assisted Combination Therapy of NSCLC: New Platinum-Based Anticancer Drug Synergizes the Therapeutic Efficacy of Ganetespib.
    Nanotheranostics, 2019, Volume: 3, Issue:1

    Topics: A549 Cells; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; CHO Cells; Cricetulus; Humans; Lung Neoplasms; Magnetic Fields; Magnetite Nanoparticles; Nanomedicine; Organoplatinum Compounds; Proto-Oncogene Proteins p21(ras); Triazoles

2019
Ganetespib in Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor-resistant Non-small Cell Lung Cancer.
    Anticancer research, 2019, Volume: 39, Issue:4

    Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Resistance, Neoplasm; ErbB Receptors; Female; HSP90 Heat-Shock Proteins; Humans; Lung Neoplasms; Mice, Inbred BALB C; Mice, Nude; Mutation; Protein Kinase Inhibitors; Proto-Oncogene Mas; Signal Transduction; Triazoles; Tumor Burden; Xenograft Model Antitumor Assays

2019
XPO1 inhibitor KPT-330 synergizes with Bcl-xL inhibitor to induce cancer cell apoptosis by perturbing rRNA processing and Mcl-1 protein synthesis.
    Cell death & disease, 2019, 05-21, Volume: 10, Issue:6

    Topics: Animals; Antineoplastic Agents; Apoptosis; Benzothiazoles; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Down-Regulation; Drug Synergism; Eukaryotic Initiation Factor-4F; Exportin 1 Protein; Humans; Hydrazines; Isoquinolines; Karyopherins; Lung Neoplasms; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred NOD; Mice, SCID; Myeloid Cell Leukemia Sequence 1 Protein; Receptors, Cytoplasmic and Nuclear; RNA, Ribosomal; Triazoles

2019
Genomic signatures defining responsiveness to allopurinol and combination therapy for lung cancer identified by systems therapeutics analyses.
    Molecular oncology, 2019, Volume: 13, Issue:8

    Topics: Allopurinol; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genomics; Humans; Janus Kinase 2; Lung Neoplasms; Mice, Nude; Phenotype; Protein Kinase Inhibitors; Pyridines; Systems Analysis; Triazoles; Xenograft Model Antitumor Assays

2019
Bromodomain and extraterminal domain inhibition synergizes with WEE1-inhibitor AZD1775 effect by impairing nonhomologous end joining and enhancing DNA damage in nonsmall cell lung cancer.
    International journal of cancer, 2020, 02-15, Volume: 146, Issue:4

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Azepines; Carcinoma, Non-Small-Cell Lung; Cell Cycle Proteins; Cell Line, Tumor; DNA Breaks, Double-Stranded; DNA End-Joining Repair; DNA-Binding Proteins; Drug Synergism; Female; Gene Knockdown Techniques; Heterocyclic Compounds, 2-Ring; Humans; Lung Neoplasms; Mice; Piperazines; Protein-Tyrosine Kinases; Pyrazoles; Pyridazines; Pyrimidinones; Transcription Factors; Triazoles; Xenograft Model Antitumor Assays

2020
The triazole linked galactose substituted dicyano compound can induce autophagy in NSCLC cell lines.
    Gene, 2019, Sep-05, Volume: 712

    Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chloroquine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Galactose; Humans; Inhibitory Concentration 50; Lung Neoplasms; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Naphthyridines; Signal Transduction; TOR Serine-Threonine Kinases; Triazoles

2019
Hypoxia imaging with [¹⁸F]HX4 PET in NSCLC patients: defining optimal imaging parameters.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2013, Volume: 109, Issue:1

    Topics: Adult; Aged; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Female; Fluorine Radioisotopes; Humans; Imidazoles; Lung Neoplasms; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Triazoles

2013
Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2013, Nov-15, Volume: 19, Issue:22

    Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Azepines; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Lung Neoplasms; Mice; Mice, Knockout; Nuclear Proteins; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins p21(ras); RNA Interference; RNA, Small Interfering; Signal Transduction; Transcription Factors; Triazoles

2013
American Society of Clinical Oncology Annual Meeting 2013.
    The Lancet. Respiratory medicine, 2013, Volume: 1, Issue:5

    Topics: Antibodies, Monoclonal; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Docetaxel; Erlotinib Hydrochloride; Female; Humans; Imidazoles; Indoles; Lung Neoplasms; Male; Medical Oncology; Multicenter Studies as Topic; Oximes; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quinazolines; Randomized Controlled Trials as Topic; Small Cell Lung Carcinoma; Societies, Medical; Sulfones; Sunitinib; Taxoids; Treatment Outcome; Triazoles; United States

2013
mTOR inhibition potentiates HSP90 inhibitor activity via cessation of HSP synthesis.
    Molecular cancer research : MCR, 2014, Volume: 12, Issue:5

    Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Female; Heat-Shock Response; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Lung Neoplasms; Male; Mice; Mice, SCID; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Random Allocation; Signal Transduction; TOR Serine-Threonine Kinases; Triazoles; Up-Regulation; Xenograft Model Antitumor Assays

2014
Antitumor effects of a novel chromosome region maintenance 1 (CRM1) inhibitor on non-small cell lung cancer cells in vitro and in mouse tumor xenografts.
    PloS one, 2014, Volume: 9, Issue:3

    Topics: Acrylates; Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Down-Regulation; Enzyme Activation; Exportin 1 Protein; Humans; Karyopherins; Lung Neoplasms; Mice, Inbred NOD; Mice, SCID; Receptors, Cytoplasmic and Nuclear; Triazoles; Xenograft Model Antitumor Assays

2014
KPT-330 has antitumour activity against non-small cell lung cancer.
    British journal of cancer, 2014, Jul-15, Volume: 111, Issue:2

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Growth Processes; Cell Line, Tumor; Cisplatin; Exportin 1 Protein; G1 Phase; Genes, p53; Humans; Hydrazines; Karyopherins; Lung Neoplasms; Male; Mice; Mice, Inbred NOD; Mice, SCID; Mutation; Receptors, Cytoplasmic and Nuclear; Triazoles; Xenograft Model Antitumor Assays

2014
Receptor ligand-triggered resistance to alectinib and its circumvention by Hsp90 inhibition in EML4-ALK lung cancer cells.
    Oncotarget, 2014, Jul-15, Volume: 5, Issue:13

    Topics: Benzoquinones; Blotting, Western; Carbazoles; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Epidermal Growth Factor; ErbB Receptors; Hepatocyte Growth Factor; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Ligands; Lung Neoplasms; Mutation; Oncogene Proteins, Fusion; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Transforming Growth Factor alpha; Triazoles

2014
The HSP90 inhibitor ganetespib potentiates the antitumor activity of EGFR tyrosine kinase inhibition in mutant and wild-type non-small cell lung cancer.
    Targeted oncology, 2015, Volume: 10, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; ErbB Receptors; Female; HSP90 Heat-Shock Proteins; Humans; Lung Neoplasms; Mice, SCID; Mutation; Protein Kinase Inhibitors; Signal Transduction; Time Factors; Triazoles; Tumor Burden; Xenograft Model Antitumor Assays

2015
In vivo quantification of hypoxic and metabolic status of NSCLC tumors using [18F]HX4 and [18F]FDG-PET/CT imaging.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2014, Dec-15, Volume: 20, Issue:24

    Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Female; Fluorodeoxyglucose F18; Humans; Hypoxia; Image Interpretation, Computer-Assisted; Image Processing, Computer-Assisted; Imidazoles; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Staging; Positron-Emission Tomography; Radiopharmaceuticals; Tomography, X-Ray Computed; Triazoles

2014
TH-302 in Combination with Radiotherapy Enhances the Therapeutic Outcome and Is Associated with Pretreatment [18F]HX4 Hypoxia PET Imaging.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2015, Jul-01, Volume: 21, Issue:13

    Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Chemoradiotherapy; Imidazoles; Lung Neoplasms; Nitroimidazoles; Phosphoramide Mustards; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Treatment Outcome; Triazoles; Xenograft Model Antitumor Assays

2015
NSCLC Driven by DDR2 Mutation Is Sensitive to Dasatinib and JQ1 Combination Therapy.
    Molecular cancer therapeutics, 2015, Volume: 14, Issue:10

    Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Azepines; Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Dasatinib; Discoidin Domain Receptors; Humans; Inhibitory Concentration 50; Lung Neoplasms; Mice, Nude; Mutation, Missense; N-Myc Proto-Oncogene Protein; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptors, Mitogen; Triazoles; Tumor Burden; Xenograft Model Antitumor Assays

2015
Discovery of novel hybrids of diaryl-1,2,4-triazoles and caffeic acid as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase for cancer therapy.
    European journal of medicinal chemistry, 2016, Jan-27, Volume: 108

    Topics: Antineoplastic Agents; Apoptosis; Arachidonate 5-Lipoxygenase; Caffeic Acids; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Lipoxygenase Inhibitors; Lung Neoplasms; Molecular Structure; Structure-Activity Relationship; Triazoles

2016
Hsp90 Inhibitor Ganetespib Sensitizes Non-Small Cell Lung Cancer to Radiation but Has Variable Effects with Chemoradiation.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2016, Dec-01, Volume: 22, Issue:23

    Topics: A549 Cells; Animals; Carboplatin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chemoradiotherapy; Female; HSP90 Heat-Shock Proteins; Humans; Lung Neoplasms; Mice; Mice, Nude; Paclitaxel; Radiation-Sensitizing Agents; Triazoles; Xenograft Model Antitumor Assays

2016
Inhibition of BET bromodomain-dependent XIAP and FLIP expression sensitizes KRAS-mutated NSCLC to pro-apoptotic agents.
    Cell death & disease, 2016, 09-08, Volume: 7, Issue:9

    Topics: A549 Cells; Acetanilides; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azepines; Benzodiazepines; Carcinoma, Non-Small-Cell Lung; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Cycle; Cell Line, Tumor; Cisplatin; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 3-Ring; Humans; Lung Neoplasms; Mice, SCID; Mutation; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins p21(ras); Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Triazoles; X-Linked Inhibitor of Apoptosis Protein; Xenograft Model Antitumor Assays

2016
Combination Therapy of NSCLC Using Hsp90 Inhibitor and Doxorubicin Carrying Functional Nanoceria.
    Molecular pharmaceutics, 2017, 03-06, Volume: 14, Issue:3

    Topics: A549 Cells; Acrylic Resins; Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cerium; Combined Modality Therapy; Doxorubicin; Drug Carriers; Folic Acid; HSP90 Heat-Shock Proteins; Humans; Lung Neoplasms; Nanoparticles; Rats; Reactive Oxygen Species; Triazoles

2017
The BET bromodomain inhibitor JQ1 radiosensitizes non-small cell lung cancer cells by upregulating p21.
    Cancer letters, 2017, 04-10, Volume: 391

    Topics: Animals; Azepines; Carcinoma, Non-Small-Cell Lung; Female; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Radiation Tolerance; Triazoles; Up-Regulation

2017
Use of a novel Arg-Gly-Asp radioligand, 18F-AH111585, to determine changes in tumor vascularity after antitumor therapy.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2009, Volume: 50, Issue:1

    Topics: Animals; Antineoplastic Agents; Carcinoma, Lewis Lung; Carcinoma, Non-Small-Cell Lung; Dose-Response Relationship, Drug; Mice; Neoplasms; Oligopeptides; Paclitaxel; Peptides; Polyethylene Glycols; Positron-Emission Tomography; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Tissue Distribution; Triazoles

2009
Evaluation of the value of attribution in the interpretation of adverse event data: a North Central Cancer Treatment Group and American College of Surgeons Oncology Group investigation.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Jun-20, Volume: 28, Issue:18

    Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Benzamides; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase III as Topic; Double-Blind Method; Female; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Lung Neoplasms; Male; Middle Aged; Piperazines; Placebos; Pyrimidines; Randomized Controlled Trials as Topic; Retrospective Studies; Survival Rate; Treatment Outcome; Triazoles; Young Adult

2010
Synergistic activity of the Hsp90 inhibitor ganetespib with taxanes in non-small cell lung cancer models.
    Investigational new drugs, 2012, Volume: 30, Issue:6

    Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Docetaxel; Drug Combinations; Female; HSP90 Heat-Shock Proteins; Humans; Mice; Mice, SCID; Paclitaxel; Taxoids; Triazoles; Tumor Burden; Xenograft Model Antitumor Assays

2012
Platinum(II) complexes with 5,7-disubstituted-1,2,4-triazolo [1,5-a]pyrimidines: spectroscopical characterization and cytotoxic activity in vitro.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2012, Volume: 91

    Topics: Antineoplastic Agents; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Female; Humans; Magnetic Resonance Spectroscopy; Organoplatinum Compounds; Pyrimidines; Triazoles

2012
Ganetespib (STA-9090), a nongeldanamycin HSP90 inhibitor, has potent antitumor activity in in vitro and in vivo models of non-small cell lung cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, Sep-15, Volume: 18, Issue:18

    Topics: Animals; Antineoplastic Agents; Benzoquinones; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Female; HSP90 Heat-Shock Proteins; Humans; Intramolecular Oxidoreductases; Lactams, Macrocyclic; Lung Neoplasms; Mice; Mice, SCID; Prostaglandin-E Synthases; Protein Binding; Protein Stability; Triazoles; Xenograft Model Antitumor Assays

2012
Anti-proliferative effect of cytohesin inhibition in gefitinib-resistant lung cancer cells.
    PloS one, 2012, Volume: 7, Issue:7

    Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cytoplasm; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; ErbB Receptors; Gefitinib; Gene Expression Regulation, Neoplastic; Guanine Nucleotide Exchange Factors; Humans; Lung Neoplasms; Male; Mice; Mice, Nude; Neoplasm Transplantation; Quinazolines; Receptor, IGF Type 1; Signal Transduction; Triazoles

2012
Co-expression of estrogen receptor beta and aromatase in Japanese lung cancer patients: gender-dependent clinical outcome.
    Life sciences, 2012, Oct-22, Volume: 91, Issue:15-16

    Topics: Aged; Androgens; Aromatase; Aromatase Inhibitors; Asian People; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Estrogen Receptor beta; Estrogens; Female; Gene Expression Regulation, Neoplastic; Humans; Letrozole; Lung; Lung Neoplasms; Male; Middle Aged; Nitriles; Sex Factors; Testosterone; Treatment Outcome; Triazoles

2012
The synergistic effect of EGFR tyrosine kinase inhibitor gefitinib in combination with aromatase inhibitor anastrozole in non-small cell lung cancer cell lines.
    Lung cancer (Amsterdam, Netherlands), 2012, Volume: 78, Issue:3

    Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Synergism; ErbB Receptors; Estrogen Receptor alpha; Estrogen Receptor beta; Extracellular Signal-Regulated MAP Kinases; Gefitinib; Gene Expression; Humans; Inhibitory Concentration 50; Lung Neoplasms; MAP Kinase Signaling System; Nitriles; Protein Kinase Inhibitors; Protein Transport; Proto-Oncogene Proteins c-akt; Quinazolines; Triazoles

2012
Targeting KRAS-mutant non-small cell lung cancer with the Hsp90 inhibitor ganetespib.
    Molecular cancer therapeutics, 2012, Volume: 11, Issue:12

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Female; Genes, ras; Humans; Imidazoles; Lung Neoplasms; Mice; Mice, Nude; Mutation; Phosphoinositide-3 Kinase Inhibitors; Quinolines; Signal Transduction; TOR Serine-Threonine Kinases; Triazoles; Xenograft Model Antitumor Assays

2012
Multiple analyses of G-protein coupled receptor (GPCR) expression in the development of gefitinib-resistance in transforming non-small-cell lung cancer.
    PloS one, 2012, Volume: 7, Issue:10

    Topics: Adenosine A2 Receptor Antagonists; Antineoplastic Agents; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Fibroblasts; Gefitinib; Humans; Lung; Lung Neoplasms; Oligonucleotide Array Sequence Analysis; Pyrimidines; Quinazolines; Receptor, Adenosine A2A; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Transcriptome; Triazoles

2012
Acute cerebrovascular accident after cisplatin treatment in a patient taking letrozole.
    Chemotherapy, 2012, Volume: 58, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Female; Hemianopsia; Humans; Letrozole; Lung Neoplasms; Middle Aged; Nitriles; Stroke; Triazoles

2012
Aromatase inhibitors in human lung cancer therapy.
    Cancer research, 2005, Dec-15, Volume: 65, Issue:24

    Topics: Anastrozole; Androstenedione; Animals; Aromatase; Aromatase Inhibitors; Carcinoma, Non-Small-Cell Lung; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoblotting; Immunoenzyme Techniques; Lung Neoplasms; Male; Mice; Mice, Nude; Nitriles; Ovariectomy; Reverse Transcriptase Polymerase Chain Reaction; Transplantation, Heterologous; Triazoles

2005
A CK2-dependent mechanism for degradation of the PML tumor suppressor.
    Cell, 2006, Jul-28, Volume: 126, Issue:2

    Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Casein Kinase II; Cell Line; Cell Line, Transformed; Cell Line, Tumor; Enzyme Activation; Enzyme Inhibitors; Genes, Tumor Suppressor; Green Fluorescent Proteins; Hemagglutinins; Humans; Leupeptins; Lung Neoplasms; Mice; Mice, Transgenic; Molecular Sequence Data; Neoplasm Proteins; NIH 3T3 Cells; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Promyelocytic Leukemia Protein; Proteasome Endopeptidase Complex; Protein Structure, Tertiary; Protein Subunits; RNA, Small Interfering; Sequence Deletion; Serine; Sorbitol; Transcription Factors; Transcriptional Activation; Triazoles; Tumor Suppressor Proteins; Ubiquitin

2006
C421 allele-specific ABCG2 gene amplification confers resistance to the antitumor triazoloacridone C-1305 in human lung cancer cells.
    Biochemical pharmacology, 2007, Jun-30, Volume: 74, Issue:1

    Topics: Acridines; Aminoacridines; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Gene Amplification; Gene Expression Regulation, Neoplastic; Heterozygote; Humans; Indoles; Irinotecan; Mitoxantrone; Neoplasm Proteins; RNA, Messenger; Triazoles

2007