Page last updated: 2024-09-27

Dent Disease

X-linked recessive NEPHROLITHIASIS characterized by HYPERCALCIURIA; HYPOPHOSPHATEMIA; NEPHROCALCINOSIS; and PROTEINURIA. It is associated with mutations in the voltage-gated chloride channel, CLC-5 (Dent Disease I). Another group of mutations associated with this disease is in phosphatidylinositol 4,5-bisphosphate-5-phosphatase gene.

Synonyms(3)

Synonym
Dents Disease
Dent's Disease
Dent Disease

Research Excerpts

Overview

ExcerptReference
"The symptoms of Dent disease are replicated in Clcn5 knock-out mice."( Cha, B; Donowitz, M; Duan, X; Guggino, SE; Hubbard, A; Hulamm, P; Jin, S; Lin, Z; Martini, S; Wang, T, 2011)
"Dent's disease is a rare X-linked condition caused by a mutation in CLCN5 and OCRL gene, which impair the megalin-cubilin receptor-mediated endocytosis in kidney's proximal tubules."( Aizawa, M; Asanuma, K; Empitu, MA; Ishii, M; Lee, C; Makino, S; Naito, T; Wakabayashi, H, 2020)
"Dent disease is an X-linked form of progressive renal disease."( Duan, N; Huang, C; Jiang, S; Li, H; Pang, L; Yang, W, 2021)

Research

Studies (20)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's15 (75.00)28.8240
2020's5 (25.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
methane0medium11
chlorine0low10
hydrogen carbonate0low10
kynurenine0medium11
acetaminophen0medium22
gentamicin0low10
hydrochlorothiazide0low10
ibuprofen0medium11
sulfamethoxazole0medium11
prednisolone0low10
carbon tetrachloride0medium11
carvone0medium11
catechin0medium11
thiazoles0low10
fusarium0medium11
diallyl disulfide0medium11
palladium0medium11
epigallocatechin gallate0medium11
triazoles0medium11
glycerophosphoinositol 4,5-bisphosphate0low10
levofloxacin0medium11
amylopectin0medium11
retinol0low10
pectins0medium11
calcitriol0low10
tofacitinib0medium11
angiotensinogen0low10
chitosan0medium11
sodium glutamate0medium11
piperidines0medium11
glpg06340medium11
byl7190low10
cyclosporine0low10

Protein Targets (887)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
RAR-related orphan receptor gamma5005
ATAD5 protein, partial2002
GLS protein3003
Microtubule-associated protein tau7007
Smad31001
aldehyde dehydrogenase 1 family, member A16006
thyroid stimulating hormone receptor3003
nuclear receptor subfamily 1, group I, member 34004
progesterone receptor2002
EWS/FLI fusion protein3003
retinoic acid nuclear receptor alpha variant 16006
retinoid X nuclear receptor alpha4004
estrogen-related nuclear receptor alpha7007
estrogen nuclear receptor alpha7007
peroxisome proliferator activated receptor gamma4004
aryl hydrocarbon receptor3003
chromobox protein homolog 13003
thyroid hormone receptor beta isoform 25005
peripheral myelin protein 223003
cytochrome P450 3A4 isoform 13003
Gamma-aminobutyric acid receptor subunit pi3003
ATP-binding cassette sub-family C member 30808
Multidrug resistance-associated protein 40808
Solute carrier family 22 member 60303
Carbonic anhydrase 120202
UDP-glucuronosyltransferase 1A90001
Bile salt export pump0303
Voltage-dependent calcium channel gamma-2 subunit3003
Bile salt export pump010010
Cytochrome P450 2B10001
Cytochrome P450 1A10001
Carbonic anhydrase 10505
Carbonic anhydrase 20606
Myoglobin0101
Cytochrome P450 1A10012
Cytochrome P450 1A20103
Prostaglandin G/H synthase 10314
Carbonic anhydrase 30202
Cytochrome P450 3A40607
Cytochrome P450 2D60404
Cytochrome P450 2C9 0708
Polyunsaturated fatty acid lipoxygenase ALOX150101
Gamma-aminobutyric acid receptor subunit beta-13003
Sulfotransferase 1A1 0001
Gamma-aminobutyric acid receptor subunit delta3003
Gamma-aminobutyric acid receptor subunit gamma-23003
UDP-glucuronosyltransferase 1-60001
Glutamate receptor 23003
Gamma-aminobutyric acid receptor subunit alpha-53003
Gamma-aminobutyric acid receptor subunit alpha-33003
Arachidonate 5-lipoxygenase-activating protein0101
UDP-glucuronosyltransferase 1A1 0001
Carbonic anhydrase 40505
Prostaglandin G/H synthase 10303
Carbonic anhydrase 60303
Gamma-aminobutyric acid receptor subunit gamma-13003
Gamma-aminobutyric acid receptor subunit alpha-23003
Gamma-aminobutyric acid receptor subunit alpha-43003
Gamma-aminobutyric acid receptor subunit gamma-33003
Gamma-aminobutyric acid receptor subunit alpha-63003
Carbonic anhydrase 5A, mitochondrial0202
Prostaglandin G/H synthase 20315
Carbonic anhydrase 70202
Nuclear receptor ROR-gamma2002
Cytochrome P450 2J20404
Gamma-aminobutyric acid receptor subunit alpha-13003
Gamma-aminobutyric acid receptor subunit beta-33003
Gamma-aminobutyric acid receptor subunit beta-23003
Carbonic anhydrase 90202
GABA theta subunit3003
Canalicular multispecific organic anion transporter 10808
Carbonic anhydrase 150303
Carbonic anhydrase 130202
Gamma-aminobutyric acid receptor subunit epsilon3003
Carbonic anhydrase 140202
Carbonic anhydrase 5B, mitochondrial0202
toxin B0001
PPM1D protein4004
cytochrome P450 family 3 subfamily A polypeptide 42002
G2002
Bone morphogenetic protein receptor type-1B0033
Membrane-associated progesterone receptor component 10033
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform0112
Serine/threonine-protein kinase PLK40033
ATP-dependent RNA helicase DDX3X0033
Pyridoxal kinase0033
Citron Rho-interacting kinase0033
Serine/threonine-protein kinase Chk10134
Aurora kinase A0033
Cyclin-G-associated kinase0033
Ephrin type-B receptor 60033
Peroxisomal acyl-coenzyme A oxidase 30033
Receptor-interacting serine/threonine-protein kinase 20033
Dynamin-like 120 kDa protein, mitochondrial0033
Eukaryotic translation initiation factor 5B0022
Rho-associated protein kinase 20134
Serine/threonine-protein kinase ULK10033
Serine/threonine-protein kinase/endoribonuclease IRE10033
Ribosomal protein S6 kinase alpha-50134
U5 small nuclear ribonucleoprotein 200 kDa helicase0033
Ribosomal protein S6 kinase alpha-40033
Serine/threonine-protein kinase 160033
Serine/threonine-protein kinase 100033
Serine/threonine-protein kinase D30033
Structural maintenance of chromosomes protein 20022
Mitogen-activated protein kinase kinase kinase 60033
Mitogen-activated protein kinase kinase kinase kinase 40033
Serine/threonine-protein kinase LATS10033
Serine/threonine-protein kinase PAK 40033
Tyrosine-protein kinase ABL10033
Epidermal growth factor receptor0235
Interferon beta6006
HLA class I histocompatibility antigen, B alpha chain 2002
Cellular tumor antigen p535106
Guanine nucleotide-binding protein G(i) subunit alpha-20011
ADP/ATP translocase 20033
Protein kinase C beta type0033
Insulin receptor0134
Tyrosine-protein kinase Lck0134
Tyrosine-protein kinase Fyn0033
Cyclin-dependent kinase 10033
Glycogen phosphorylase, liver form0033
Tyrosine-protein kinase Fes/Fps0033
Adenine phosphoribosyltransferase0022
Tyrosine-protein kinase Yes0033
Tyrosine-protein kinase Lyn0033
Proto-oncogene tyrosine-protein kinase receptor Ret0033
Insulin-like growth factor 1 receptor0033
Signal recognition particle receptor subunit alpha0033
Cytochrome c1, heme protein, mitochondrial0033
Hepatocyte growth factor receptor0235
Tyrosine-protein kinase HCK0033
Platelet-derived growth factor receptor beta0033
Serine/threonine-protein kinase A-Raf0033
Glycogen phosphorylase, brain form0033
Breakpoint cluster region protein0033
Serine/threonine-protein kinase pim-10033
Fibroblast growth factor receptor 10033
DNA topoisomerase 2-alpha0022
Cyclin-dependent kinase 40033
ADP/ATP translocase 30033
Inosine-5'-monophosphate dehydrogenase 20022
Proto-oncogene tyrosine-protein kinase Src0033
cAMP-dependent protein kinase type II-alpha regulatory subunit0022
Serine/threonine-protein kinase B-raf0033
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0033
Ribosyldihydronicotinamide dehydrogenase [quinone]0033
Tyrosine-protein kinase Fer0033
Protein kinase C alpha type0134
cAMP-dependent protein kinase catalytic subunit alpha0033
General transcription and DNA repair factor IIH helicase subunit XPD0033
Casein kinase II subunit alpha'0033
Ras-related protein Rab-6A0033
Ephrin type-A receptor 10033
Multifunctional protein ADE20033
cAMP-dependent protein kinase catalytic subunit gamma0033
cAMP-dependent protein kinase catalytic subunit beta0033
Ferrochelatase, mitochondrial0033
Ribosomal protein S6 kinase beta-10134
Tyrosine-protein kinase JAK105411
Cyclin-dependent kinase 20134
Beta-adrenergic receptor kinase 10033
Probable ATP-dependent RNA helicase DDX60033
Mitogen-activated protein kinase 3 0033
MAP/microtubule affinity-regulating kinase 30033
Deoxycytidine kinase0033
Phosphatidylinositol 3-kinase regulatory subunit alpha0101
Mitogen-activated protein kinase 10033
Ephrin type-A receptor 20033
Ephrin type-B receptor 20033
Non-receptor tyrosine-protein kinase TYK205411
UMP-CMP kinase 0022
Phosphatidylethanolamine-binding protein 10022
Wee1-like protein kinase0033
Heme oxygenase 20033
S-adenosylmethionine synthase isoform type-20033
DnaJ homolog subfamily A member 10033
RAC-alpha serine/threonine-protein kinase0134
RAC-beta serine/threonine-protein kinase0033
Delta-type opioid receptor0202
DNA replication licensing factor MCM40022
Dual specificity mitogen-activated protein kinase kinase 20033
Receptor-type tyrosine-protein kinase FLT30134
Bone morphogenetic protein receptor type-1A0033
Activin receptor type-1B0033
TGF-beta receptor type-10033
Electron transfer flavoprotein subunit beta0022
Tyrosine-protein kinase CSK0134
Glycine--tRNA ligase0033
Protein kinase C iota type0033
Exosome RNA helicase MTR40033
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform0213
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform0112
Serine/threonine-protein kinase mTOR0112
Tyrosine-protein kinase Tec0134
Tyrosine-protein kinase ABL20033
Tyrosine-protein kinase FRK0033
Tyrosine-protein kinase SYK0033
26S proteasome regulatory subunit 6B0033
Mitogen-activated protein kinase 80134
Mitogen-activated protein kinase 90033
Dual specificity mitogen-activated protein kinase kinase 40033
Dual specificity mitogen-activated protein kinase kinase 30033
Casein kinase I isoform alpha0033
Casein kinase I isoform delta0033
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0112
MAP kinase-activated protein kinase 20134
Elongation factor Tu, mitochondrial0033
Cysteine--tRNA ligase, cytoplasmic0022
Casein kinase I isoform epsilon0033
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0033
Dual specificity protein kinase CLK10022
Dual specificity protein kinase CLK20033
Glycogen synthase kinase-3 alpha0033
Glycogen synthase kinase-3 beta0134
Cyclin-dependent kinase 70033
Cyclin-dependent kinase 90033
Interleukin-1 receptor-associated kinase 10033
Ribosomal protein S6 kinase alpha-30134
Serine/threonine-protein kinase Nek20033
Serine/threonine-protein kinase Nek30033
Dual specificity mitogen-activated protein kinase kinase 60033
LIM domain kinase 10033
LIM domain kinase 20033
Mitogen-activated protein kinase 100033
Tyrosine--tRNA ligase, cytoplasmic0033
5'-AMP-activated protein kinase subunit gamma-10033
Ephrin type-B receptor 30033
Ephrin type-A receptor 50033
Ephrin type-B receptor 40033
Ephrin type-A receptor 40033
Adenylate kinase 2, mitochondrial0033
Adenosine kinase0033
Ras-related protein Rab-100033
Actin-related protein 30033
Actin-related protein 20022
GTP-binding nuclear protein Ran0033
DNA-dependent protein kinase catalytic subunit0101
Cyclin-dependent kinase 30033
Cyclin-dependent kinase 60033
Cyclin-dependent-like kinase 5 0134
Cyclin-dependent kinase 160033
ATP-dependent 6-phosphofructokinase, platelet type0033
Dual specificity mitogen-activated protein kinase kinase 10033
DNA topoisomerase 2-beta0033
Protein kinase C theta type0033
Activin receptor type-10033
Macrophage-stimulating protein receptor0033
Focal adhesion kinase 10033
Protein kinase C delta type0033
Tyrosine-protein kinase BTK0134
Activated CDC42 kinase 10033
Epithelial discoidin domain-containing receptor 10033
Mitogen-activated protein kinase kinase kinase kinase 20033
Serine/threonine-protein kinase 40033
5'-AMP-activated protein kinase catalytic subunit alpha-10033
Dual specificity mitogen-activated protein kinase kinase 50033
Mitogen-activated protein kinase 70033
Serine/threonine-protein kinase PAK 20033
Serine/threonine-protein kinase 30033
Mitogen-activated protein kinase kinase kinase 10033
Serine-protein kinase ATM0101
Rho-associated protein kinase 10033
Non-receptor tyrosine-protein kinase TNK10033
Serine/threonine-protein kinase ATR0134
Calcium/calmodulin-dependent protein kinase type II subunit gamma0033
Calcium/calmodulin-dependent protein kinase type II subunit delta0033
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0134
Bone morphogenetic protein receptor type-20033
Protein-tyrosine kinase 60033
cGMP-dependent protein kinase 1 0033
Cyclin-dependent kinase 130033
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0033
Protein-tyrosine kinase 2-beta0033
Maternal embryonic leucine zipper kinase0033
Structural maintenance of chromosomes protein 1A0022
Chromodomain-helicase-DNA-binding protein 40033
Peroxisomal acyl-coenzyme A oxidase 10022
Ephrin type-A receptor 70033
Delta(24)-sterol reductase0022
Ribosomal protein S6 kinase alpha-10033
Dual specificity testis-specific protein kinase 10033
Myosin light chain kinase, smooth muscle0033
Serine/threonine-protein kinase STK110033
Serine/threonine-protein kinase N10033
Serine/threonine-protein kinase N20033
Mitogen-activated protein kinase 140235
Mitogen-activated protein kinase kinase kinase 110033
Discoidin domain-containing receptor 20033
AP2-associated protein kinase 10033
Myosin light chain kinase 30033
Putative heat shock protein HSP 90-beta 20033
Serine/threonine-protein kinase MRCK alpha0033
Serine/threonine-protein kinase MRCK gamma0033
Acyl-CoA dehydrogenase family member 100033
Serine/threonine-protein kinase ULK30033
Uncharacterized protein FLJ452520033
Acyl-CoA dehydrogenase family member 110022
Serine/threonine-protein kinase/endoribonuclease IRE20033
Serine/threonine-protein kinase MARK20033
Serine/threonine-protein kinase TAO10033
STE20-related kinase adapter protein alpha0033
Myosin-140033
AarF domain-containing protein kinase 10033
Mitogen-activated protein kinase kinase kinase kinase 30033
MAP kinase-activated protein kinase 50235
Misshapen-like kinase 10033
Phosphatidylinositol 3-kinase catalytic subunit type 30101
Atypical kinase COQ8A, mitochondrial0033
Mitogen-activated protein kinase 150033
Serine/threonine-protein kinase Nek90033
ATP-dependent RNA helicase DDX10033
Inositol hexakisphosphate kinase 12002
Aurora kinase B0033
Serine/threonine-protein kinase Nek10033
Calcium/calmodulin-dependent protein kinase kinase 20033
EKC/KEOPS complex subunit TP53RK0033
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0033
Mitogen-activated protein kinase kinase kinase 50033
Mitogen-activated protein kinase kinase kinase 30033
Eukaryotic translation initiation factor 2-alpha kinase 10033
Nucleolar GTP-binding protein 10033
Serine/threonine-protein kinase D20033
NUAK family SNF1-like kinase 20033
RNA cytidine acetyltransferase0033
Serine/threonine-protein kinase SIK20033
STE20-like serine/threonine-protein kinase 0033
Serine/threonine-protein kinase TAO30033
dCTP pyrophosphatase 10033
Dual specificity protein kinase CLK40033
Casein kinase I isoform gamma-10033
Phenylalanine--tRNA ligase beta subunit0033
Isoleucine--tRNA ligase, mitochondrial0022
BMP-2-inducible protein kinase0033
Obg-like ATPase 10022
Midasin0033
Interleukin-1 receptor-associated kinase 40033
Mitogen-activated protein kinase kinase kinase 200033
Cyclin-dependent kinase 120033
Serine/threonine-protein kinase 260033
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0033
5'-AMP-activated protein kinase subunit gamma-20033
Serine/threonine-protein kinase TBK10134
Septin-90033
Ribosomal protein S6 kinase alpha-60033
TRAF2 and NCK-interacting protein kinase0033
Serine/threonine-protein kinase TAO20033
Serine/threonine-protein kinase ICK0033
RAC-gamma serine/threonine-protein kinase0033
Serine/threonine-protein kinase SIK30033
Mitogen-activated protein kinase kinase kinase 20033
Thyroid hormone receptor-associated protein 30022
Mitogen-activated protein kinase kinase kinase kinase 50033
Receptor-interacting serine/threonine-protein kinase 30033
Serine/threonine-protein kinase MRCK beta0033
Interleukin-1 receptor-associated kinase 30033
Casein kinase I isoform gamma-30033
Mitogen-activated protein kinase kinase kinase 40033
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform0101
cytochrome P450 2C9, partial2002
Chain A, Vitamin D Nuclear Receptor0011
Chain A, Beta-lactamase1001
Chain A, Ferritin light chain1001
Vitamin D3 receptor0011
USP1 protein, partial3003
thioredoxin glutathione reductase2002
euchromatic histone-lysine N-methyltransferase 26006
mitogen-activated protein kinase 12002
nuclear receptor ROR-gamma isoform 13003
geminin6006
Vitamin D-binding protein0011
Androgen receptor0303
Vitamin D3 receptor0124
Vitamin D3 receptor0113
Retinoic acid receptor RXR-alpha0011
Cytochrome P450 2C190303
Kappa-type opioid receptor0011
Vitamin D3 receptor0011
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0011
Vitamin D3 receptor0112
Transporter0101
Vitamin D3 receptor A0022
pregnane X receptor2002
peroxisome proliferator-activated receptor delta2002
potassium voltage-gated channel subfamily H member 2 isoform d2002
lethal factor (plasmid)1001
lamin isoform A-delta103003
Cytochrome P450 2E10202
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE4004
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, 2-oxoglutarate Oxygenase4004
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
thioredoxin reductase3003
arylsulfatase A3003
Bloom syndrome protein isoform 11001
peripheral myelin protein 22 isoform 12002
DNA polymerase beta3003
flap endonuclease 11001
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)2002
DNA polymerase kappa isoform 12002
survival motor neuron protein isoform d2002
neuropeptide S receptor isoform A1001
Prostaglandin G/H synthase 1 0202
Arginase 0202
Pancreatic triacylglycerol lipase0101
Prothrombin0112
Aldo-keto reductase family 1 member B10101
Sucrase-isomaltase, intestinal0101
Adenosine receptor A11203
Adenosine receptor A2a0202
Mu-type opioid receptor0001
Delta-type opioid receptor0001
Kappa-type opioid receptor0001
Xanthine dehydrogenase/oxidase0101
Melatonin receptor type 1A0011
Melatonin receptor type 1B0011
Death-associated protein kinase 10112
Beta-secretase 10202
Prostaglandin G/H synthase 20303
Carbonic anhydrase 30101
Dihydroorotate dehydrogenase 0101
ATP-dependent phosphofructokinase2002
Carbonic anhydrase0202
15-lipoxygenase, partial2002
AR protein5005
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a3003
Histone H2A.x2002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
vitamin D3 receptor isoform VDRA2002
Transient receptor potential cation channel subfamily A member 10011
Fatty acid synthase0202
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Chain A, Troponin C, slow skeletal and cardiac muscles0011
Chain A, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10011
Chain A, POLYMERASE PA0101
Chain A, Polymerase Pa0101
Chain A, Polymerase Pa0101
Chain A, Polymerase Pa0101
Chain A, Polymerase Pa0101
Genome polyprotein 0101
Luciferase2002
acetylcholinesterase3003
phosphopantetheinyl transferase3003
hypoxia-inducible factor 1 alpha subunit2002
GLI family zinc finger 35005
bromodomain adjacent to zinc finger domain 2B1001
thyroid stimulating hormone receptor2002
activating transcription factor 62002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
v-jun sarcoma virus 17 oncogene homolog (avian)3003
Replicase polyprotein 1ab0202
lysosomal alpha-glucosidase preproprotein1001
galactokinase1001
thyroid hormone receptor beta isoform a2002
heat shock protein beta-12002
pyruvate kinase PKM isoform a1001
nuclear factor NF-kappa-B p105 subunit isoform 11001
nuclear factor erythroid 2-related factor 2 isoform 13003
POsterior Segregation0011
Prostaglandin E synthase0101
Telomerase reverse transcriptase0101
Polycomb protein EED0011
NAD kinase0213
Dihydrofolate reductase0102
Urokinase-type plasminogen activator0101
Tissue-type plasminogen activator0101
Transthyretin0011
Polymerase acidic protein0101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Amyloid-beta precursor protein0202
Plasminogen activator inhibitor 10101
Heme oxygenase 1 0101
Urokinase-type plasminogen activator0101
ATP-dependent translocase ABCB10102
Heat shock protein HSP 90-beta0101
Neutrophil elastase0101
72 kDa type IV collagenase0101
Matrilysin0101
60 kDa chaperonin0101
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI0101
Replicase polyprotein 1ab0101
Alpha-amylase 1A 0101
Apoptosis regulator Bcl-20202
Microtubule-associated protein tau0101
60 kDa heat shock protein, mitochondrial0101
Glucose-6-phosphate 1-dehydrogenase0101
CPG DNA methylase0101
Lethal factor0101
Phosphoglycerate mutase 10101
Cannabinoid receptor 10101
Heme oxygenase 20101
Sodium-dependent noradrenaline transporter 0011
DNA (cytosine-5)-methyltransferase 10101
Dipeptidyl peptidase 40101
Proteasome subunit beta type-50101
Cannabinoid receptor 2 0101
Signal transducer and activator of transcription 1-alpha/beta0011
DNA repair protein RAD52 homolog0101
Fatty acid synthase0101
Matrix metalloproteinase-140101
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT60101
Squalene monooxygenase 0101
6-phosphogluconate dehydrogenase, decarboxylating0101
BH3-interacting domain death agonist0101
10 kDa heat shock protein, mitochondrial0101
Disintegrin and metalloproteinase domain-containing protein 171102
Lactoperoxidase0001
Bcl-2-like protein 10101
Induced myeloid leukemia cell differentiation protein Mcl-10101
Histone acetyltransferase p3000101
Alpha-(1,3)-fucosyltransferase 70101
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 10101
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10101
Bcl-2-related protein A10101
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
Sigma non-opioid intracellular receptor 10101
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0101
Reverse transcriptase/RNaseH 0101
10 kDa chaperonin 0101
3-oxoacyl-[acyl-carrier-protein] reductase 0101
CREB-binding protein0101
Histone acetyltransferase KAT2B0101
Bcl-2-like protein 20101
Bcl2-associated agonist of cell death 0101
Histone acetyltransferase KAT50101
Enoyl-acyl-carrier protein reductase 0202
3-oxoacyl-acyl-carrier protein reductase 0101
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)0101
Bcl-2-like protein 100101
Zinc finger protein mex-50011
Mitotic checkpoint serine/threonine-protein kinase BUB10022
Tyrosine-protein kinase JAK205310
High affinity nerve growth factor receptor0022
Macrophage colony-stimulating factor 1 receptor0112
Cytochrome P450 2C80202
Cytochrome P450 2B60101
Myosin-100011
Vascular endothelial growth factor receptor 30112
TGF-beta receptor type-20022
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha0011
Choline-phosphate cytidylyltransferase A0011
Ras-related protein Rab-27A0011
Tyrosine-protein kinase JAK305311
Serine/threonine-protein kinase PLK10022
Ras-related C3 botulinum toxin substrate 10011
Casein kinase I isoform gamma-20022
Cyclin-dependent kinase 170022
Potassium voltage-gated channel subfamily H member 20303
Integrin-linked protein kinase0022
Activin receptor type-2B0022
Mitogen-activated protein kinase 110123
Calcium/calmodulin-dependent protein kinase type IV0022
Uncharacterized aarF domain-containing protein kinase 50022
Jak1 protein0101
Rab-like protein 30022
ATP-dependent RNA helicase DHX300022
ATP-dependent RNA helicase DDX420011
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0022
Serine/threonine-protein kinase Nek70022
Mitogen-activated protein kinase kinase kinase kinase 10022
MAP/microtubule affinity-regulating kinase 40022
Serine/threonine-protein kinase PAK 60022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 130022
Serine/threonine-protein kinase pim-20022
Serine/threonine-protein kinase NLK0022
ALK tyrosine kinase receptor0022
Serine/threonine-protein kinase 38-like0022
Serine/threonine-protein kinase 240022
Carbonic anhydrase 0101
Hsf1 protein0011
glucocorticoid receptor [Homo sapiens]3003
Carbonic anhydrase 0101
cytochrome P450 2C9 precursor1001
Albumin0213
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Histamine H2 receptor1001
Spike glycoprotein3003
Guanine nucleotide-binding protein G1001
Mu-type opioid receptor0202
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0101
Delta carbonic anhydrase0101
NFKB1 protein, partial1001
nonstructural protein 11001
67.9K protein1001
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
IDH11001
transcriptional regulator ERG isoform 31001
importin subunit beta-1 isoform 11001
snurportin-11001
muscleblind-like protein 1 isoform 11001
Acid-sensing ion channel 30101
Solute carrier organic anion transporter family member 1A40101
Prostaglandin G/H synthase 2 0101
Fatty acid-binding protein, liver0202
Albumin0101
Albumin0011
Cholinesterase0101
Fatty acid-binding protein, intestinal0101
Polyunsaturated fatty acid 5-lipoxygenase0102
UDP-glucuronosyltransferase 2B70001
Acetylcholinesterase0101
Prostaglandin G/H synthase 10101
Caspase-10101
Substance-P receptor0101
Prostaglandin G/H synthase 2 0102
UDP-glucuronosyltransferase 1A30001
Aldo-keto reductase family 1 member C30101
Caspase-30101
Solute carrier organic anion transporter family member 1A10101
Caspase-40101
4-aminobutyrate aminotransferase, mitochondrial0101
Caspase-50101
Caspase-90101
Acid-sensing ion channel 10101
Fatty-acid amide hydrolase 10202
Prostaglandin G/H synthase 20101
TAR DNA-binding protein 431001
Solute carrier family 22 member 60101
Prostaglandin G/H synthase 1 0102
Solute carrier family 22 member 200101
Solute carrier family 22 member 80101
Solute carrier family 22 member 60101
Dehydrogenase/reductase SDR family member 90101
Chain A, JmjC domain-containing histone demethylation protein 3A1001
TDP1 protein3003
CAAX prenyl protease 2 isoform 20001
histone acetyltransferase KAT2A isoform 11001
streptokinase A precursor0011
Tubulin beta-4A chain0101
Tubulin beta chain0101
Tubulin alpha-3C chain0101
Tubulin alpha-1B chain0101
Tubulin alpha-4A chain0101
Tubulin beta-4B chain0101
DNA gyrase subunit A0101
DNA primase0101
Tubulin beta-3 chain0101
Tubulin beta-2A chain0101
Tubulin beta-8 chain0101
Tubulin alpha-3E chain0101
Tubulin alpha-1A chain0101
Multidrug and toxin extrusion protein 10101
Tubulin alpha-1C chain0101
Tubulin beta-6 chain0101
Tubulin beta-2B chain0101
Tubulin beta-1 chain0101
luciferase0001
pregnane X nuclear receptor2002
nuclear receptor subfamily 1, group I, member 21001
nuclear factor erythroid 2-related factor 2 isoform 21001
Estrogen receptor0202
Glucocorticoid receptor0218
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10202
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Glutamine synthetase0011
Androgen receptor0101
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Histamine H1 receptor0011
Nociceptin receptor0011
Estrogen receptor beta0202
ATPase family AAA domain-containing protein 51001
Ataxin-21001
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
Chain A, Cruzipain1001
interleukin 82002
SMAD family member 21001
SMAD family member 31001
estrogen receptor 2 (ER beta)1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
Retinol-binding protein 40011
Beta-lactoglobulin0011
Alpha-synuclein0101
farnesoid X nuclear receptor1001
exodeoxyribonuclease V subunit RecD0101
exodeoxyribonuclease V subunit RecB0101
exodeoxyribonuclease V subunit RecC0101
ATP-dependent 6-phosphofructokinase0101
Dihydropteroate synthase0101
5-hydroxytryptamine receptor 2A0101
Dihydrofolate reductase0101
Endothelin-1 receptor0101
Protease 0112
Protein-arginine deiminase type-40101
Chain A, Tyrosine-protein kinase0101
Chain A, Tyrosine-protein kinase0101
Chain A, Tyrosine-protein kinase JAK20101
Leukotriene C4 synthase0011
tyrosine-protein kinase Yes1001
Serine/threonine-protein kinase Sgk10101
Serine/threonine-protein kinase 250011
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta0011
Serine/threonine-protein kinase RIO30011
Dual specificity mitogen-activated protein kinase kinase 70112
Inhibitor of nuclear factor kappa-B kinase subunit beta0011
Peripheral plasma membrane protein CASK0011
Serine/threonine-protein kinase DCLK10011
Inhibitor of nuclear factor kappa-B kinase subunit alpha0011
Muscle, skeletal receptor tyrosine-protein kinase0011
Mitogen-activated protein kinase 130112
3-phosphoinositide-dependent protein kinase 10011
Mitogen-activated protein kinase kinase kinase 130011
Death-associated protein kinase 30011
Mitogen-activated protein kinase kinase kinase 70011
NUAK family SNF1-like kinase 10011
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma0011
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma0011
Serine/threonine-protein kinase PAK 30011
Cyclin-dependent kinase-like 50011
Serine/threonine-protein kinase 17B0011
Cyclin-dependent kinase 140011
Serine/threonine-protein kinase OSR10011
Serine/threonine-protein kinase Chk20011
RAF proto-oncogene serine/threonine-protein kinase0011
Receptor tyrosine-protein kinase erbB-20112
Proto-oncogene tyrosine-protein kinase ROS0011
Tyrosine-protein kinase Fgr0011
Wee1-like protein kinase 20011
Uncharacterized serine/threonine-protein kinase SBK30011
Mast/stem cell growth factor receptor Kit0011
Cytochrome P450 2A60101
Myosin light chain kinase, smooth muscle0011
Insulin receptor-related protein0011
Platelet-derived growth factor receptor alpha0011
Vascular endothelial growth factor receptor 1 0011
5-hydroxytryptamine receptor 1A0101
Interferon-induced, double-stranded RNA-activated protein kinase0011
Serine/threonine-protein kinase MAK0011
Cyclin-dependent kinase 11B0011
Fibroblast growth factor receptor 20011
Receptor tyrosine-protein kinase erbB-30011
Fibroblast growth factor receptor 40011
Fibroblast growth factor receptor 30011
Protein kinase C eta type0011
Activin receptor type-2A0011
Ephrin type-A receptor 30011
Ephrin type-A receptor 80011
Leukocyte tyrosine kinase receptor0011
Tyrosine-protein kinase receptor UFO0011
Mitogen-activated protein kinase 40011
G protein-coupled receptor kinase 40011
Dual specificity protein kinase TTK0011
Tyrosine-protein kinase receptor Tie-10011
Vascular endothelial growth factor receptor 20011
Serine/threonine-protein kinase receptor R30011
Megakaryocyte-associated tyrosine-protein kinase0011
Tyrosine-protein kinase TXK0112
Tyrosine-protein kinase ZAP-700011
Cyclin-dependent kinase 80011
Dual specificity protein kinase CLK30011
Tyrosine-protein kinase Blk0112
Cytoplasmic tyrosine-protein kinase BMX0112
cAMP-dependent protein kinase catalytic subunit PRKX0011
Serine/threonine-protein kinase Nek40011
Mitogen-activated protein kinase 120112
5'-AMP-activated protein kinase catalytic subunit alpha-20011
Ephrin type-B receptor 10011
Hormonally up-regulated neu tumor-associated kinase0011
Serine/threonine-protein kinase SIK10011
Receptor-interacting serine/threonine-protein kinase 40011
Cell division control protein 2 homolog0011
Calcium-dependent protein kinase 10011
Tubulin alpha-1A chain0011
Casein kinase II subunit alpha0011
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta0011
SRSF protein kinase 20011
Mitogen-activated protein kinase kinase kinase 90011
Serine/threonine-protein kinase PknB0011
Cyclin-dependent kinase-like 10011
Glutamate receptor ionotropic, NMDA 2B0101
Protein kinase C epsilon type0011
Angiopoietin-1 receptor0011
Mitogen-activated protein kinase kinase kinase 100011
Tyrosine-protein kinase receptor TYRO30011
Cyclin-dependent kinase 180011
Tyrosine-protein kinase ITK/TSK0112
Myotonin-protein kinase0011
Mitogen-activated protein kinase kinase kinase 120011
Tyrosine-protein kinase Mer0011
Serine/threonine-protein kinase PAK 10011
cGMP-dependent protein kinase 20011
Serine/threonine-protein kinase PRP4 homolog0011
Receptor-interacting serine/threonine-protein kinase 10011
Calcium/calmodulin-dependent protein kinase type II subunit beta0011
Calcium/calmodulin-dependent protein kinase type 10011
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial0101
Serine/threonine-protein kinase D10011
Serine/threonine-protein kinase 380011
Receptor tyrosine-protein kinase erbB-40112
Ribosomal protein S6 kinase alpha-20011
Rhodopsin kinase GRK10011
NT-3 growth factor receptor0011
BDNF/NT-3 growth factors receptor0011
Mitogen-activated protein kinase 60011
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform0011
Serine/threonine-protein kinase SBK10011
Mitogen-activated protein kinase kinase kinase 190011
Serine/threonine-protein kinase TNNI3K0011
Leucine-rich repeat serine/threonine-protein kinase 20011
Sigma intracellular receptor 20101
Tyrosine-protein kinase JAK30101
Tyrosine-protein kinase JAK20101
Tyrosine-protein kinase JAK30101
Serine/threonine-protein kinase Nek50011
Dual serine/threonine and tyrosine protein kinase0011
Mitogen-activated protein kinase kinase kinase 150011
Serine/threonine-protein kinase tousled-like 20011
Serine/threonine-protein kinase 32C0011
Serine/threonine-protein kinase pim-30011
Serine/threonine-protein kinase VRK20011
Myosin light chain kinase family member 40011
Homeodomain-interacting protein kinase 10011
Calcium/calmodulin-dependent protein kinase type 1D0011
Cyclin-dependent kinase-like 30011
Serine/threonine-protein kinase BRSK20011
Serine/threonine-protein kinase NIM10011
Serine/threonine-protein kinase ULK20011
Serine/threonine-protein kinase DCLK20011
Calcium/calmodulin-dependent protein kinase kinase 10011
Casein kinase I isoform alpha-like0011
Homeodomain-interacting protein kinase 40011
Myosin-IIIa0011
Ankyrin repeat and protein kinase domain-containing protein 10011
Serine/threonine-protein kinase Nek110011
Serine/threonine-protein kinase BRSK10011
Serine/threonine-protein kinase 350011
Rhodopsin kinase GRK70011
Serine/threonine-protein kinase 32A0011
Myosin-IIIb0011
Dual specificity tyrosine-phosphorylation-regulated kinase 20011
Cyclin-dependent kinase-like 20011
Serine/threonine-protein kinase Sgk30011
Atypical kinase COQ8B, mitochondrial0011
Calcium/calmodulin-dependent protein kinase type 1G0011
Cyclin-dependent kinase 150011
PAS domain-containing serine/threonine-protein kinase0011
Dual specificity testis-specific protein kinase 20011
SRSF protein kinase 10011
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha0011
Serine/threonine-protein kinase RIO10011
MAP kinase-interacting serine/threonine-protein kinase 10011
Serine/threonine-protein kinase RIO20011
Cyclin-dependent kinase 190011
Transient receptor potential cation channel subfamily M member 60011
Testis-specific serine/threonine-protein kinase 10011
Serine/threonine-protein kinase 330011
Serine/threonine-protein kinase DCLK30011
Myosin light chain kinase 2, skeletal/cardiac muscle0011
Homeodomain-interacting protein kinase 20011
Tyrosine-protein kinase Srms0011
Homeodomain-interacting protein kinase 30011
Serine/threonine-protein kinase PLK30011
MAP kinase-interacting serine/threonine-protein kinase 20011
Serine/threonine-protein kinase Nek60011
SNF-related serine/threonine-protein kinase0011
Serine/threonine-protein kinase LATS20011
Serine/threonine-protein kinase 360011
Serine/threonine-protein kinase 32B0011
Serine/threonine-protein kinase PLK20011
Serine/threonine-protein kinase MARK10011
Serine/threonine-protein kinase PAK 50011
eIF-2-alpha kinase GCN20011
Phosphatidylinositol 4-kinase beta0011
Serine/threonine-protein kinase 17A0011
STE20/SPS1-related proline-alanine-rich protein kinase0011
Ephrin type-A receptor 60011
Death-associated protein kinase 20011
Serine/threonine-protein kinase tousled-like 10011
Long-chain-fatty-acid--CoA ligase 50011
SRSF protein kinase 30011
Cyclin-dependent kinase 11A0011
Aurora kinase C0011
Calcium/calmodulin-dependent protein kinase type II subunit alpha0011
Microtubule-associated serine/threonine-protein kinase 10011
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0011
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]