An EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor that interferes with the action of Delta(14)-sterol reductase (EC 1.3.1.70).
ChEBI ID: 83319
| Member | Definition | Class |
|---|---|---|
| loceryl | A member of the class of morpholines that is cis-2,6-dimethylmorpholine in which the hydrogen attached to the nitrogen is replaced by a racemic 2-methyl-3-[p-(2-methylbutan-2-yl)phenyl]propyl group. An inhibitor of the action of squalene monooxygenase, Delta(14) reductase and D7-D8 isomerase and an antifungal agent, it is used (generally as its hydrochloride salt) for the topical treatment of fungal nail and skin infections. | amorolfine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 16 (8.79) | 18.7374 |
| 1990's | 46 (25.27) | 18.2507 |
| 2000's | 41 (22.53) | 29.6817 |
| 2010's | 60 (32.97) | 24.3611 |
| 2020's | 19 (10.44) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 37 (18.78%) | 5.53% |
| Reviews | 23 (11.68%) | 6.00% |
| Case Studies | 22 (11.17%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 115 (58.38%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| activating transcription factor 6 | Homo sapiens (human) | Potency | 23.9145 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 27.3441 | 5 | 5 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 29.8493 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 29.8493 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 24.5454 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 4.8975 | 1 | 1 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 15.4871 | 1 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 29.2153 | 6 | 6 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 25.7565 | 3 | 3 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 23.4850 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 24.5454 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 13.3359 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 26.6032 | 2 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 22.6142 | 2 | 2 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 49.1940 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 24.5454 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 26.8325 | 2 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 24.5454 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 24.5454 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 30.7312 | 2 | 2 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 26.8325 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 31.6228 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 23.9145 | 1 | 1 |
| polyprotein | Zika virus | Potency | 23.4850 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 28.2262 | 2 | 2 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 2.3914 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 39.8107 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 33.4983 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 12.3572 | 2 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 29.8493 | 2 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 15.6992 | 2 | 2 |