A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active insecticide for which it is a proacaricide.
ChEBI ID: 136647
| Member | Definition | Class |
|---|---|---|
| chlorfenapyr | A member of the class of pyrroles that is 4-bromo-1H-pyrrole-3-carbonitrile which is substituted at positions 1, 2 and 5 by ethoxymethyl, p-chlorophenyl and trifluoromethyl groups, respectively. A proinsecticide used for termite control and crop protection against several insects and mite pests. | chlorfenapyr |
| cyenopyrafen | A member of the class of pyrazoles that is ethene in which the hydrogens at position 1 have been replaced by p-tert-butylphenyl and cyano groups, while the hydrogens at position 2 have been replaced by pivaloyloxy and 1,3,4-trimethylpyrazol-5-yl groups (the E isomer). A proacaricide (by hydrolysis of the pivalate ester linkage to give the corresponding enol), it was formerly used for the control of mites in fruit, vegetables and tea. | cyenopyrafen |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 31 (18.67) | 29.6817 |
| 2010's | 67 (40.36) | 24.3611 |
| 2020's | 68 (40.96) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 8 (4.79%) | 5.53% |
| Reviews | 6 (3.59%) | 6.00% |
| Case Studies | 11 (6.59%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 142 (85.03%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| activating transcription factor 6 | Homo sapiens (human) | Potency | 21.8724 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 1.4102 | 8 | 8 |
| Ataxin-2 | Homo sapiens (human) | Potency | 0.5448 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 0.5448 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 5.9070 | 3 | 3 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 9.6885 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 8.3860 | 11 | 11 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 12.1972 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 0.8988 | 6 | 6 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 35.9977 | 3 | 3 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 0.4711 | 2 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 14.2869 | 4 | 4 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 1.9331 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 5.8293 | 2 | 2 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 61.6448 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 14.0378 | 2 | 2 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 13.1169 | 3 | 3 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 22.2628 | 4 | 4 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 41.4508 | 4 | 4 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 1.3685 | 1 | 1 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 0.8913 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 12.1972 | 2 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 0.8091 | 2 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 2.6164 | 2 | 2 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 2.0675 | 4 | 4 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 6.0624 | 2 | 2 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 6.0624 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 1.0997 | 2 | 2 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 34.3899 | 3 | 3 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 45.0830 | 2 | 2 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 21.7833 | 4 | 4 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 1.9331 | 1 | 1 |