1,3-diphenyl-1-triazene

Description

1,3-diphenyl-1-triazene is an organic compound with the formula **C₁₃H₁₁N₃**. It's a **white solid** and is primarily used as a **reagent in organic synthesis**.

**Here's why it's important for research:**

* **Versatile synthetic tool:** 1,3-diphenyl-1-triazene can be used to introduce **azido groups** into molecules, which are important functional groups with diverse applications in chemistry and biology.
* **Click chemistry:** The azido group reacts efficiently with alkynes in a **copper-catalyzed azide-alkyne cycloaddition (CuAAC)**, a widely used click reaction for generating triazoles. This allows for the rapid and reliable synthesis of a variety of complex molecules, including pharmaceuticals and biomaterials.
* **Drug discovery:** The triazole ring formed by the CuAAC reaction has been shown to exhibit **pharmacological activity**, making 1,3-diphenyl-1-triazene a valuable tool in drug discovery research.
* **Material science:** Triazoles are also used in the synthesis of **polymers and other materials** with specific properties.

**Specific examples of its use:**

* Synthesis of **anticancer agents:** 1,3-diphenyl-1-triazene has been used to synthesize triazole-based compounds with potential anticancer activity.
* Development of **biocompatible materials:** Triazoles created using 1,3-diphenyl-1-triazene have been used in the development of biocompatible materials for drug delivery and tissue engineering.
* **Probing protein-protein interactions:** The azide group can be used to tag proteins, which can then be used to study protein-protein interactions.

**In summary,** 1,3-diphenyl-1-triazene is a versatile reagent that plays a significant role in various fields of research, including organic chemistry, drug discovery, and material science. Its ability to introduce azido groups, which can be used in click chemistry reactions, makes it an essential tool for building complex molecules and developing new materials with tailored properties.

1,3-diphenyl-1-triazene: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]