Beuren Syndrome

A disorder caused by hemizygous microdeletion of about 28 genes on chromosome 7q11.23, including the ELASTIN gene. Clinical manifestations include SUPRAVALVULAR AORTIC STENOSIS; MENTAL RETARDATION; elfin facies; impaired visuospatial constructive abilities; and transient HYPERCALCEMIA in infancy. The condition affects both sexes, with onset at birth or in early infancy.

Synonym
Hypercalcemia-Supravalvar Aortic Stenosis
Beuren Syndrome
Williams Syndrome
Contiguous Gene Syndrome, Williams
Williams Contiguous Gene Syndrome
Williams-Beuren Syndrome
Chromosome 7q11.23 Deletion Syndrome
Supravalvar Aortic Stenosis Syndrome

Excerpt	Reference
"Williams syndrome is a developmental disorder affecting predominantly connective tissue and the central nervous system."	( Smoot, LB, 1995)
"Williams syndrome is a complex developmental disorder."	( Boyd, DC; Csiszár, K; Fekete, G; Kádár, K; Kiss, E; Szabolcs, J; Urbán, Z, 1997)
"Williams syndrome is a rare neurodevelopmental disorder with variable phenotypic expression and a contiguous gene syndrome caused by deletion of the elastin gene."	( Berry, AC; Daker, M; Elçioglu, N; Mackie-Ogilvie, C, 1998)
"Individuals with Williams syndrome are hemizygous for the elastin gene, owing to a 1 to 2 megabase deletion of a portion of the long arm of chromosome 7 that encompasses ELN."	( Morris, CA, 1998)
"The Williams syndrome is a relatively rare disease with characteristic facial appearance, mental retardation, growth deficiency, cardiovascular anomalies, hypercalcemia and multiple organic dysfunctions."	( Borrelli Júnior, M; Borrelli, M; Freire, Gde C; Marinelli, CM; Sakuramoto, PK; Spinola, RT; Tobias-Machado, M, 1998)
"Williams syndrome is a rare disease associated with a characteristic facies, supravalvular aortic stenosis, and mental retardation."	( Hirose, Y; Kawahito, S; Kimura, H; Kitahata, H; Oshita, S; Sakai, Y; Tanaka, K, 1998)
"Williams-Beuren syndrome is a rare syndrome for which diagnosis is usually made during early childhood."	( Baudon, JJ; Burglen, L; Chavet, MS; de Montgolfier-Aubron, I; Gold, F; Perrot, C; Tevissen, H, 2000)
"Williams-Beuren syndrome is a rare and usually sporadic genetic anomaly with an estimated frequency of 1:25,000, that also has cardiac defects due to the effect on the elastin locus of a deletion on the 7th chromosome."	( Bal, F; Bayata, S; Gürbüz, A; Yetkin, U, 2004)
"Williams-Beuren syndrome is a neurodevelopmental disorder mainly characterized by dysmorphic features, vascular stenoses, abnormalities of calcium and glucose metabolism, and mental retardation with visuospatial deficits, caused by de novo deletion of 26-28 genes at 7q11."	( Antonell, A; Pérez Jurado, LA; Vilardell, M, 2010)
"Williams-Beuren syndrome is a genomic disorder caused by a hemizygous contiguous gene deletion on chromosome 7q11."	( Bruschini, H; de Bessa, J; Gomes, CM; Honjo, RS; Kim, CA; Pinheiro, MS; Sammour, ZM; Srougi, M; Trigo-Rocha, FE, 2012)
"Williams-Beuren syndrome is a rare congenital disorder involving the cardiovascular system, mental retardation, distinctive facial features, and tooth anomalies."	( Campos-Lara, P; Garrocho-Rangel, JA; Pozos-Guillén, AJ; Ruiz-Rodríguez, MS; Santos-Diaz, MA, 2012)
"Williams-Beuren syndrome is a multisystemic genetic disorder caused by a contiguous gene deletion at 7q11."	( Cunha, Pda S; de Aguiar, MJ; Frasson, M; Gonçalves-Dornelas, H; Leão, LL; Stofanko, M; Viana, MM, 2013)
"Williams-Beuren syndrome is a genetic disorder rarely associated with seizures."	( Bello-Espinosa, L; McLeod, DR; Myers, KA, 2013)
"Williams syndrome is a relatively rare genetic disorder caused by the hemizygous microdeletion of a region in chromosome 7q11."	( McDougle, CJ; Mullett, JE; Pineiro, ML; Pober, BR; Roberts, AM; Waxler, JL, 2014)
"Williams-Beuren syndrome is caused by a chromosome 7q11."	( Barros Filho, TE; Cristante, AF; Damasceno, ML; Marcon, RM, 2014)
"Williams-Beuren syndrome is a rare neurodevelopmental disorder, characterized by congenital heart defects, abnormal facial features, mental retardation with specific cognitive and behavioral profile, growth hormone deficiency, renal and skeletal anomalies, inguinal hernia, infantile hypercalcaemia."	( Abidi, K; Ben Rabeh, R; Gargah, T; Hammi, Y; Jellouli, M, 2015)
"Williams syndrome is a genetic neurodevelopmental disorder characterized by an uncommon hypersociability and a mosaic of retained and compromised linguistic and cognitive abilities."	( Ard, MC; Bardy, C; Bellugi, U; Brown, TT; Chailangkarn, T; Dai, L; Dale, AM; DeWitt, M; Freitas, BC; Gage, FH; Halgren, E; Hanson, KL; Herai, RH; Hrvoj-Mihic, B; Jacobs, B; Järvinen, A; Korenberg, JR; Lai, P; Marchetto, MC; McHenry, L; Muotri, AR; Romero, S; Searcy, YM; Semendeferi, K; Stefanacci, L; Trujillo, CA; Wong, W; Yu, DX, 2016)
"Williams syndrome is a well-recognised congenital disorder characterised by cardiovascular, connective tissue, and central nervous system abnormalities."	( Babu-Narayan, SV; Franklin, RC; Voges, I; Wage, R, 2017)
"Williams-Beuren syndrome is the clinical manifestation of a congenital genetic disorder in the elastin gene, among others."	( Castro Parga, L; Durán la Fuente, P; Gónzalez Rocafort, A; Lucena Delgado, J; Reinoso Barbero, F; Sanabria Carretero, P, 2018)
"Williams-Beuren syndrome is a genetic disorder characterized by physiological and mental abnormalities, and is caused by hemizygous deletion of several genes in chromosome 7."	( Chang, CF; Dontsova, OA; Efimov, SV; Huang, TH; Klochkov, VV; Mariasina, SS; Osterman, IA; Petrova, OA; Polshakov, VI; Sergeeva, OV; Sergiev, PV, 2018)
"Williams-Beuren syndrome is a chromosomal disorder caused by a deletion at region 7q11."	( Bruschini, H; de Bessa, J; Gomes, CM; Hisano, M; Nahas, WC; Sammour, ZM; Srougi, M, 2021)
"Williams syndrome is an autosomal dominant multisystem disorder caused by a 1."	( Gao, X; Jia, YX; Li, CG; Meng, H; Wang, YM; Xin, GY; Yang, HM, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	6 (2.29)	23.3326
1990's	59 (22.52)	12.5806
2000's	72 (27.48)	18.1394
2010's	95 (36.26)	28.8240
2020's	30 (11.45)	9.53

Drug	Relationship Strength	Studies	Trials
phosphoserine	low	1	0
gamma-aminobutyric acid	low	1	0
glycine	low	1	0
alpha-glycerophosphoric acid	low	1	0
melatonin	low	5	0
nitrous oxide	low	2	0
phosphorylcholine	low	1	0
phosphorylethanolamine	low	1	0
uric acid	low	1	0
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid	low	1	0
acetaminophen	low	1	0
acetovanillone	low	1	0
baclofen	low	1	0
bupivacaine	low	1	0
buspirone	low	1	0
verapamil	low	1	0
chloral hydrate	low	1	0
clonazepam	low	1	0
dapi	low	1	0
diphenhydramine	low	1	0
doxazosin	low	1	0
fentanyl	low	1	0
furosemide	low	2	0
ethidium	low	1	0
hydroxychloroquine	low	1	0
hydroxyurea	low	1	0
ifosfamide	low	1	0
2-propanol	low	3	0
ketamine	low	1	0
losartan	low	2	0
methylphenidate	medium	4	2
midazolam	low	1	0
minoxidil	medium	1	1
apnea	low	1	0
activins	low	1	0
nefazodone	low	1	0
nicardipine	low	1	0
nifedipine	low	1	0
oxybutynin	medium	3	1
pamidronate	low	6	0
propranolol	low	1	0
risperidone	low	1	0
sevoflurane	low	5	0
sibutramine	low	1	0
corticosterone	low	2	0
prednisolone	low	2	0
thyroxine	low	5	0
aldosterone	low	2	0
triiodothyronine	low	3	0
serine	low	2	0
aspartic acid	low	1	0
phenylephrine	low	2	0
methylprednisolone	low	1	0
catechin	low	1	0
4-hydroxybutyric acid	low	1	0
acetylcysteine	low	1	0
s,n,n'-tripropylthiocarbamate	low	2	0
n-methylaspartate	low	1	0
gadolinium	low	1	0
clemastine	low	1	0
etoposide	low	2	0
propiconazole	low	2	0
fomesafen	low	1	0
fenoxycarb	low	1	0
irinotecan	low	1	0
oseltamivir	low	1	0
epigallocatechin gallate	low	1	0
n-acetylaspartic acid	low	1	0
iopamidol	low	1	0
triazoles	low	1	0
fluorodeoxyglucose f18	low	2	0
lopinavir	low	1	0
inositol 1-phosphate	low	1	0
imatinib mesylate	low	1	0
angiotensin ii	low	2	0
ritonavir	low	1	0
elastin	medium	130	2
oxytocin	low	3	0
inositol 3-phosphate	low	2	0
tretinoin	low	1	0
zithromax	low	1	0
isomethyleugenol	low	1	0
squalene	low	1	0
leuprolide	low	1	0
curcumin	low	1	0
u 0126	low	1	0
thiamylal	low	1	0
calcitriol	low	1	0
isotretinoin	low	1	0
phenylephrine hydrochloride	low	2	0
sirolimus	low	4	0
fluvoxamine	low	1	0
enalapril	low	1	0
everolimus	low	2	0
phosphocreatine	low	1	0
zotarolimus	low	1	0
calcimycin	low	1	0
pituitrin	low	2	0
calcitonin	low	1	0
c-peptide	low	1	0
technetium tc 99m sestamibi	low	1	0
sodium pertechnetate tc 99m	low	1	0
s-adenosylmethionine	low	1	0
jzl 184	low	1	0
trelstar	low	1	0
piperidines	low	1	0
transforming growth factor beta	low	2	0
transforming growth factor alpha	low	1	0
allopurinol	low	1	0
eye	low	3	0
ego	low	2	0
phosphorus radioisotopes	low	1	0

Protein Targets (1,378)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	13	0	0	13
RAR-related orphan receptor gamma	21	0	0	21
GLI family zinc finger 3	26	0	0	26
AR protein	36	0	0	36
aldehyde dehydrogenase 1 family, member A1	16	0	0	16
retinoic acid nuclear receptor alpha variant 1	22	0	0	22
retinoid X nuclear receptor alpha	21	0	0	21
estrogen nuclear receptor alpha	40	0	0	40
peroxisome proliferator-activated receptor delta	14	0	0	14
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	21	0	0	21
activating transcription factor 6	11	0	0	11
v-jun sarcoma virus 17 oncogene homolog (avian)	11	0	0	11
Histone H2A.x	7	0	0	7
thyroid hormone receptor beta isoform a	14	0	0	14
heat shock protein beta-1	11	0	0	11
nuclear factor erythroid 2-related factor 2 isoform 1	24	0	0	24
lamin isoform A-delta10	27	0	0	27
Voltage-dependent calcium channel gamma-2 subunit	17	0	0	17
Glutamate receptor 2	17	3	1	21
Gamma-aminobutyric acid receptor subunit pi	13	7	3	23
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	13	7	3	23
Gamma-aminobutyric acid receptor subunit delta	13	7	3	23
Gamma-aminobutyric acid receptor subunit gamma-2	13	7	5	25
Gamma-aminobutyric acid receptor subunit alpha-5	13	7	3	23
Gamma-aminobutyric acid receptor subunit alpha-3	13	7	3	23
Gamma-aminobutyric acid receptor subunit gamma-1	13	7	3	23
Gamma-aminobutyric acid receptor subunit alpha-2	13	7	3	23
Gamma-aminobutyric acid receptor subunit alpha-4	13	7	3	23
Gamma-aminobutyric acid receptor subunit gamma-3	13	7	3	23
Gamma-aminobutyric acid receptor subunit alpha-6	13	7	3	23
Gamma-aminobutyric acid receptor subunit alpha-1	13	7	5	25
Gamma-aminobutyric acid receptor subunit beta-3	13	7	3	23
Gamma-aminobutyric acid receptor subunit beta-2	13	7	5	25
Tetraspanin	0	1	0	1
Proton-coupled amino acid transporter 1	0	4	0	4
GABA theta subunit	13	7	3	23
Gamma-aminobutyric acid receptor subunit epsilon	13	7	3	23
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
ATAD5 protein, partial	12	0	0	12
GLS protein	14	0	0	14
Microtubule-associated protein tau	14	0	0	14
Smad3	9	0	0	9
thyroid stimulating hormone receptor	15	0	0	15
nuclear receptor subfamily 1, group I, member 3	18	0	0	18
progesterone receptor	20	0	0	20
EWS/FLI fusion protein	18	0	0	19
estrogen-related nuclear receptor alpha	30	0	0	30
peroxisome proliferator activated receptor gamma	20	0	0	20
aryl hydrocarbon receptor	12	0	0	12
chromobox protein homolog 1	19	0	0	19
thyroid hormone receptor beta isoform 2	27	0	0	27
peripheral myelin protein 22	19	0	0	19
cytochrome P450 3A4 isoform 1	13	0	0	13
ATP-binding cassette sub-family C member 3	0	26	0	26
Multidrug resistance-associated protein 4	0	26	0	26
Solute carrier family 22 member 6	0	3	0	3
Carbonic anhydrase 12	0	2	0	3
UDP-glucuronosyltransferase 1A9	0	0	0	2
Bile salt export pump	0	7	0	7
Bile salt export pump	0	33	0	33
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	4	0	6
Carbonic anhydrase 2	0	5	0	8
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	1	1	3
Cytochrome P450 1A2	0	4	1	7
Prostaglandin G/H synthase 1	0	2	1	3
Carbonic anhydrase 3	0	2	0	2
Cytochrome P450 3A4	0	18	1	22
Cytochrome P450 2D6	0	8	1	9
Cytochrome P450 2C9	0	15	1	17
Polyunsaturated fatty acid lipoxygenase ALOX15	0	4	0	4
Sulfotransferase 1A1	0	0	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	2
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	3	0	5
Carbonic anhydrase 4	0	4	0	5
Prostaglandin G/H synthase 1	0	3	0	3
Carbonic anhydrase 6	0	3	0	4
Carbonic anhydrase 5A, mitochondrial	0	3	0	4
Prostaglandin G/H synthase 2	0	3	0	4
Carbonic anhydrase 7	0	2	0	3
Nuclear receptor ROR-gamma	6	1	1	8
Cytochrome P450 2J2	0	8	0	8
Carbonic anhydrase 9	0	3	0	5
Canalicular multispecific organic anion transporter 1	0	27	0	28
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	2	0	3
Carbonic anhydrase 14	0	2	0	3
Carbonic anhydrase 5B, mitochondrial	0	2	0	3
toxin B	0	0	0	1
TDP1 protein	35	0	0	35
geminin	33	0	0	33
Chain A, JmjC domain-containing histone demethylation protein 3A	7	0	0	7
Chain A, 2-oxoglutarate Oxygenase	11	0	0	11
Chain A, ATP-DEPENDENT DNA HELICASE Q1	6	0	0	6
acetylcholinesterase	9	0	0	9
dopamine D1 receptor	2	0	0	2
15-lipoxygenase, partial	2	0	0	2
pregnane X receptor	7	0	0	7
phosphopantetheinyl transferase	14	0	0	14
USP1 protein, partial	18	0	0	18
NFKB1 protein, partial	6	0	0	6
Thrombopoietin	5	0	0	5
regulator of G-protein signaling 4	12	0	0	12
glucocorticoid receptor [Homo sapiens]	27	0	0	27
farnesoid X nuclear receptor	16	0	0	16
vitamin D (1,25- dihydroxyvitamin D3) receptor	10	0	0	10
arylsulfatase A	10	0	0	10
euchromatic histone-lysine N-methyltransferase 2	33	0	0	33
Bloom syndrome protein isoform 1	16	0	0	16
D(1A) dopamine receptor	14	0	0	14
flap endonuclease 1	8	0	0	8
survival motor neuron protein isoform d	12	0	0	12
muscarinic acetylcholine receptor M1	10	0	0	10
Histone deacetylase 3	0	3	0	3
Histone deacetylase 4	0	3	0	3
Guanine nucleotide-binding protein G	5	0	0	5
Histone deacetylase 1	0	4	0	4
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	4	0	4
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Ataxin-2	18	0	0	18
Histone deacetylase 8	0	4	0	4
Histone deacetylase 6	0	3	0	3
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
ATP-dependent phosphofructokinase	11	0	0	11
nuclear factor erythroid 2-related factor 2 isoform 2	9	0	0	9
Sex hormone-binding globulin	0	0	2	2
Corticosteroid-binding globulin	0	3	0	3
Mineralocorticoid receptor	0	3	4	7
Androgen receptor	0	5	0	5
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	3
interleukin 8	4	0	0	4
estrogen receptor 2 (ER beta)	12	0	0	12
IDH1	11	0	0	11
transcriptional regulator ERG isoform 3	6	0	0	6
ras-related protein Rab-9A	5	0	0	5
Polyphenol oxidase 2	0	1	0	1
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Cellular tumor antigen p53	21	0	0	21
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	1	0	1
Adenosine receptor A2a	0	2	2	4
Xanthine dehydrogenase/oxidase	0	3	0	3
Nuclear receptor ROR-gamma	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	1	4
Purine nucleoside phosphorylase	0	0	1	1
TAR DNA-binding protein 43	7	0	0	7
Shiga toxin subunit A	0	1	0	1
Histamine H3 receptor	0	1	0	2
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Integrin beta-3	3	1	0	4
Integrin alpha-IIb	3	1	0	4
Glutamate receptor 1	0	3	1	4
Glutamate receptor 3	0	3	1	4
Glutamate receptor 4	0	3	1	4
Glutamate receptor ionotropic, kainate 1	0	3	0	3
Glutamate receptor 1	0	1	1	2
Glutamate receptor 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	9	2	13
Glutamate receptor ionotropic, kainate 1	0	2	0	2
Glutamate receptor ionotropic, kainate 2	0	3	0	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	2	0	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	2
Excitatory amino acid transporter 2	0	2	0	2
Excitatory amino acid transporter 3	0	2	0	2
Glutamate receptor 4	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	9	2	13
Glutamate receptor ionotropic, NMDA 2B	0	9	2	13
Glutamate receptor ionotropic, NMDA 2C	0	9	2	13
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	3	0	3
Glutamate receptor ionotropic, NMDA 2A	0	3	0	3
Glutamate receptor ionotropic, kainate 2	0	2	0	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	3	0	3
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Glutamate receptor ionotropic, kainate 4	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	9	2	13
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	9	2	13
Glutamate receptor ionotropic, NMDA 3A	0	9	2	13
Glutamate receptor 4	0	1	0	1
Glutamate receptor 3	0	1	0	1
glucocerebrosidase	6	0	0	6
DNA polymerase kappa isoform 1	10	0	0	10
histone acetyltransferase KAT2A isoform 1	13	0	0	13
Atrial natriuretic peptide receptor 3	0	2	0	2
Type-1A angiotensin II receptor	0	4	2	6
Type-1 angiotensin II receptor	0	0	1	1
Type-1B angiotensin II receptor	0	4	0	4
Type-1 angiotensin II receptor	0	5	4	11
Type-2 angiotensin II receptor	0	5	0	5
Type-2 angiotensin II receptor	0	3	0	3
thioredoxin reductase	22	0	0	22
neuropeptide S receptor isoform A	7	0	0	7
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	12	0	0	12
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	8	0	0	8
Chain A, Ferritin light chain	11	0	0	11
cytochrome P450 2C19 precursor	5	0	0	5
lethal factor (plasmid)	5	0	0	5
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase 4	0	0	0	1
67.9K protein	10	0	0	10
Gamma-aminobutyric acid type B receptor subunit 2	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 2	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 1	0	2	0	2
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	0	2	2
Potassium channel subfamily K member 9	0	1	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	9	0	0	9
cytochrome P450 family 3 subfamily A polypeptide 4	19	0	0	19
pregnane X nuclear receptor	27	0	0	27
cytochrome P450 2D6	10	0	0	10
cytochrome P450 2D6 isoform 1	6	0	0	6
cytochrome P450 2C9 precursor	3	0	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	11	0	0	11
Solute carrier family 22 member 2	0	5	0	5
5-hydroxytryptamine receptor 1A	0	4	5	9
5-hydroxytryptamine receptor 2C	0	4	0	4
Beta-2 adrenergic receptor	0	3	0	4
Angiotensin-converting enzyme	0	3	0	3
D(2) dopamine receptor	0	8	1	9
5-hydroxytryptamine receptor 2A	0	7	0	7
Alpha-1B adrenergic receptor	0	15	2	17
Beta-1 adrenergic receptor	0	5	1	7
D	0	3	0	3
D(3) dopamine receptor	0	4	0	4
5-hydroxytryptamine receptor 1A	0	12	1	14
Alpha-2B adrenergic receptor	0	4	1	5
D(2) dopamine receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	4	1	5
Alpha-2A adrenergic receptor	0	4	1	5
Alpha-1D adrenergic receptor	0	10	2	12
Alpha-1D adrenergic receptor	0	10	1	13
D(1B) dopamine receptor	0	2	0	2
Beta-3 adrenergic receptor	0	3	0	3
5-hydroxytryptamine receptor 2A	0	13	1	14
5-hydroxytryptamine receptor 2C	0	17	1	18
5-hydroxytryptamine receptor 1B	0	8	0	8
5-hydroxytryptamine receptor 1D	0	1	0	1
D(4) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	4	0	4
5-hydroxytryptamine receptor 7	0	3	1	4
D(3) dopamine receptor	0	11	0	11
5-hydroxytryptamine receptor 2B	0	22	1	23
Alpha-1A adrenergic receptor	0	17	3	20
5-hydroxytryptamine receptor 3A	0	1	0	1
Histamine H2 receptor	5	0	0	6
5-hydroxytryptamine receptor 6	0	6	1	7
Spike glycoprotein	14	0	2	16
D(2) dopamine receptor	0	6	0	6
Potassium voltage-gated channel subfamily H member 2	0	18	0	18
Alpha-2A adrenergic receptor	0	1	0	1
D	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Multidrug and toxin extrusion protein 2	0	4	0	4
D	0	1	0	1
Multidrug and toxin extrusion protein 1	0	7	0	7
Sigma non-opioid intracellular receptor 1	0	13	0	13
Lysosomal alpha-glucosidase	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	5	0	0	5
Chain A, Cruzipain	6	0	0	6
acid sphingomyelinase	1	0	0	1
endonuclease IV	2	0	0	2
glp-1 receptor, partial	11	0	0	11
ClpP	2	0	0	2
electroneutral potassium-chloride cotransporter KCC2	0	0	1	1
Fumarate hydratase	8	0	0	8
TSHR protein	1	0	0	1
apical membrane antigen 1, AMA1	4	0	0	4
nonstructural protein 1	6	0	0	6
polyprotein	8	0	0	8
Parkin	6	0	0	6
LacZ protein (plasmid)	0	0	1	1
XBP1	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	4	0	0	4
serine-protein kinase ATM isoform a	1	0	0	1
lysosomal alpha-glucosidase preproprotein	5	0	0	5
hexokinase-4 isoform 1	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
peripheral myelin protein 22 isoform 1	7	0	0	7
type-1 angiotensin II receptor	0	1	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
vitamin D3 receptor isoform VDRA	13	0	0	13
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
glucokinase regulatory protein	1	0	0	1
huntingtin isoform 2	4	0	0	4
mitogen-activated protein kinase 1	6	0	0	6
serine/threonine-protein kinase mTOR isoform 1	7	0	0	7
serine/threonine-protein kinase PLK1	4	0	0	4
apelin receptor	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	2
DNA polymerase iota isoform a (long)	11	0	0	11
DNA damage-inducible transcript 3 protein	0	1	0	1
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
nuclear receptor ROR-gamma isoform 1	12	0	0	12
Vpr	3	0	0	3
streptokinase A precursor	0	0	2	2
Rap guanine nucleotide exchange factor 3	3	0	0	3
Amyloid-beta precursor protein	1	4	0	6
Alpha-synuclein	4	2	1	7
D(1A) dopamine receptor	3	0	0	3
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
heat shock protein 90, putative	0	0	0	2
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Chain A, Beta-lactamase	7	0	0	7
Vitamin D3 receptor	0	0	1	1
PPM1D protein	5	0	0	5
thioredoxin glutathione reductase	4	0	0	4
Interferon beta	19	0	0	19
Vitamin D-binding protein	0	0	1	1
Androgen receptor	0	4	0	4
Vitamin D3 receptor	0	1	2	4
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	2	5	7
Cytochrome P450 2C19	0	6	1	7
Kappa-type opioid receptor	0	3	1	4
Vitamin D3 receptor	0	0	1	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	2	0	2
Vitamin D3 receptor A	0	0	2	2
Chain A, HADH2 protein	6	0	0	6
Chain B, HADH2 protein	6	0	0	6
DNA polymerase beta	3	0	0	3
DNA polymerase eta isoform 1	3	0	0	3
Prostaglandin G/H synthase 1	0	1	0	1
Arginase	0	2	0	2
Pancreatic triacylglycerol lipase	0	1	0	1
Prothrombin	0	1	2	4
Aldo-keto reductase family 1 member B1	0	11	0	11
Sucrase-isomaltase, intestinal	0	1	0	1
Adenosine receptor A1	1	1	0	2
Adenosine receptor A2a	0	4	0	4
Mu-type opioid receptor	0	5	2	8
Delta-type opioid receptor	0	3	1	5
Kappa-type opioid receptor	0	5	1	7
Melatonin receptor type 1A	0	2	2	4
Melatonin receptor type 1B	0	2	2	4
Death-associated protein kinase 1	0	1	0	1
Beta-secretase 1	0	3	0	3
Prostaglandin G/H synthase 2	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
cellular tumor antigen p53 isoform a	3	0	0	3
Solute carrier family 22 member 1	0	10	0	10
Polyunsaturated fatty acid lipoxygenase ALOX15B	4	0	0	4
5-hydroxytryptamine receptor 4	0	16	0	16
Muscarinic acetylcholine receptor M2	0	9	2	13
Muscarinic acetylcholine receptor M4	0	10	0	11
Muscarinic acetylcholine receptor M5	0	8	0	9
Alpha-2A adrenergic receptor	0	10	3	14
Muscarinic acetylcholine receptor M1	0	8	1	11
Angiotensin-converting enzyme	0	9	0	9
Alpha-2B adrenergic receptor	0	11	1	13
Alpha-2C adrenergic receptor	0	10	3	14
Muscarinic acetylcholine receptor M3	0	10	1	12
D(1A) dopamine receptor	0	5	1	6
Sodium-dependent noradrenaline transporter	0	12	2	14
Histamine H2 receptor	0	6	0	6
Histamine H1 receptor	0	7	0	7
5-hydroxytryptamine receptor 7	0	3	0	3
Sodium-dependent dopamine transporter	0	11	1	12
Sigma intracellular receptor 2	0	2	0	2
Nuclear receptor subfamily 3 group C member 3	0	8	0	8
Gamma-aminobutyric acid receptor subunit pi	0	5	0	5
Gamma-aminobutyric acid receptor subunit delta	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	2
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	2
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	6	2	8
Gamma-aminobutyric acid receptor subunit beta-1	0	5	2	7
Gamma-aminobutyric acid receptor subunit gamma-2	0	6	2	8
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	6	2	8
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	5	2	7
Gamma-aminobutyric acid receptor subunit alpha-3	0	5	2	7
Gamma-aminobutyric acid receptor subunit alpha-2	0	5	2	7
Gamma-aminobutyric acid receptor subunit beta-2	0	5	2	7
Gamma-aminobutyric acid receptor subunit alpha-4	0	5	2	7
Gamma-aminobutyric acid receptor subunit epsilon	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-6	0	5	2	7
Gamma-aminobutyric acid receptor subunit gamma-1	0	5	0	5
Gamma-aminobutyric acid receptor subunit gamma-3	0	5	0	5
Gamma-aminobutyric acid receptor subunit theta	0	5	0	5
GALC protein	3	0	0	3
G	14	0	0	14
thyroid stimulating hormone receptor	14	0	0	14
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	10	0	0	10
Solute carrier family 22 member 3	0	3	0	3
Solute carrier family 22 member 3	0	1	0	1
HLA class I histocompatibility antigen, B alpha chain	14	0	0	14
C-8 sterol isomerase	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Solute carrier family 22 member 1	0	3	0	3
Inositol hexakisphosphate kinase 1	14	0	0	14
Solute carrier family 22 member 2	0	3	0	3
cytochrome P450 2C9, partial	14	0	0	14
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Luciferase	11	0	0	11
Nrf2	1	0	0	1
SMAD family member 2	6	0	0	6
SMAD family member 3	6	0	0	6
alkaline phosphatase, intestinal	0	1	0	1
caspase 7, apoptosis-related cysteine protease	4	0	0	4
PINK1	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	7	0	0	7
toll-like receptor 9	0	1	0	1
caspase-3	4	0	0	4
TPA: protein transporter TIM10	0	1	0	1
thyrotropin-releasing hormone receptor	3	0	0	3
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	1	0	1
hemoglobin subunit beta	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
perilipin-5	0	2	0	2
intestinal alkaline phosphatase precursor	0	1	0	1
perilipin-1	0	2	0	2
importin subunit beta-1 isoform 1	1	0	0	1
pyruvate kinase PKM isoform a	2	0	0	2
nuclear factor NF-kappa-B p105 subunit isoform 1	2	0	0	2
snurportin-1	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	5	0	0	5
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	6	0	0	6
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	2	0	2
muscleblind-like protein 1 isoform 1	4	0	0	4
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
alkaline phosphatase, germ cell type preproprotein	0	1	0	1
caspase-1 isoform alpha precursor	1	0	0	1
hypothetical protein SA1422	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Prostaglandin E synthase	0	2	0	2
Acetylcholinesterase	0	3	0	3
Lysine-specific histone demethylase 1A	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Phospholipase A2	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	4	0	4
Neuronal proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Cholinesterase	0	2	0	2
Heme oxygenase 1	0	2	0	2
Glutathione S-transferase P	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
60 kDa chaperonin	0	3	0	3
Replicase polyprotein 1ab	0	3	3	6
Replicase polyprotein 1ab	0	6	3	9
Microtubule-associated protein tau	0	2	0	3
60 kDa heat shock protein, mitochondrial	0	3	0	3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	0	1	0	1
Tissue factor	0	1	0	1
Tyrosinase	0	1	0	1
Aminopeptidase N	0	1	0	1
Aminopeptidase N	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	0	2	0	2
Glycogen synthase kinase-3 beta	0	1	0	1
Amine oxidase [flavin-containing] A	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	6	0	6
Acetylcholinesterase	0	5	0	5
Heme oxygenase 2	0	2	0	2
Amine oxidase [flavin-containing] B	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Proteasome subunit beta type-5	0	2	0	2
17-beta-hydroxysteroid dehydrogenase type 2	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	2	3
Caspase-7	1	0	0	1
10 kDa heat shock protein, mitochondrial	0	3	0	3
Cholinesterase	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Lactoylglutathione lyase	0	1	0	1
Histone acetyltransferase p300	0	2	0	2
Serine/threonine-protein kinase PAK 1	0	1	0	1
5-hydroxytryptamine receptor 4	0	0	1	1
Sodium/bile acid cotransporter	0	3	1	4
Nuclear factor erythroid 2-related factor 2	0	0	1	2
Thiosulfate sulfurtransferase	0	3	0	3
Thioredoxin reductase 1, cytoplasmic	0	1	0	1
60 kDa chaperonin	0	3	0	3
10 kDa chaperonin	0	3	0	3
Thioredoxin reductase 3	0	1	0	1
Sortase A	0	1	0	1
CREB-binding protein	0	2	0	2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3	0	2	0	2
Cysteine protease	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
ATPase family AAA domain-containing protein 5	12	0	0	12
Thioredoxin reductase 2, mitochondrial	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	4	0	4
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	9	1	10
Lymphocyte antigen 96	0	0	1	1
Beta lactamase (plasmid)	0	1	0	1
Prothrombin	0	1	0	1
Glandular kallikrein	0	1	0	1
Cell division protein FtsZ	0	0	1	2
Histamine H1 receptor	0	1	1	3
Histamine N-methyltransferase	0	0	0	1
Sodium channel protein type 5 subunit alpha	0	7	0	7
Calcium release-activated calcium channel protein 1	0	1	0	1
Protein orai-2	0	1	0	1
Protein orai-3	0	1	0	1
Histamine H4 receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Interstitial collagenase	0	2	0	2
Beta-2 adrenergic receptor	0	4	2	6
Alpha-1A adrenergic receptor	0	3	1	4
Sodium-dependent serotonin transporter	0	14	1	15
Alpha-1A adrenergic receptor	0	5	3	10
Alpha-1B adrenergic receptor	0	3	2	7
Succinyl-diaminopimelate desuccinylase	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Angiotensin-converting enzyme 2	0	1	2	3
Chain A, Troponin C, slow skeletal and cardiac muscles	0	0	1	1
Chain A, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	0	1	1
Chain A, POLYMERASE PA	0	1	0	1
Chain A, Polymerase Pa	0	1	0	1
Chain A, Polymerase Pa	0	1	0	1
Chain A, Polymerase Pa	0	1	0	1
Chain A, Polymerase Pa	0	1	0	1
Genome polyprotein	0	2	0	2
Replicase polyprotein 1ab	0	1	2	3
galactokinase	1	0	0	1
POsterior Segregation	0	0	1	1
Telomerase reverse transcriptase	0	1	0	1
Polycomb protein EED	0	0	1	1
NAD kinase	0	2	1	3
Dihydrofolate reductase	0	0	0	1
Urokinase-type plasminogen activator	0	1	0	1
Tissue-type plasminogen activator	0	1	0	1
Transthyretin	0	1	1	4
Polymerase acidic protein	0	1	0	1
Plasminogen activator inhibitor 1	0	1	0	1
Urokinase-type plasminogen activator	0	1	0	1
ATP-dependent translocase ABCB1	0	16	1	28
Heat shock protein HSP 90-beta	0	1	0	1
Neutrophil elastase	0	1	0	1
72 kDa type IV collagenase	0	1	0	1
Hepatocyte growth factor receptor	0	2	2	4
Matrilysin	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Alpha-amylase 1A	0	1	0	1
Apoptosis regulator Bcl-2	0	2	0	2
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Fatty acid synthase	0	1	0	1
CPG DNA methylase	0	1	0	1
Lethal factor	0	1	0	1
Phosphoglycerate mutase 1	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Cannabinoid receptor 2	0	1	0	1
Signal transducer and activator of transcription 1-alpha/beta	0	0	1	1
DNA repair protein RAD52 homolog	0	1	0	1
Fatty acid synthase	0	1	0	1
Matrix metalloproteinase-14	0	1	0	1
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6	0	1	0	1
Squalene monooxygenase	0	1	0	2
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
BH3-interacting domain death agonist	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	0	1	0	1
Lactoperoxidase	0	0	0	1
Bcl-2-like protein 1	0	1	0	1
Induced myeloid leukemia cell differentiation protein Mcl-1	0	1	0	1
Alpha-(1,3)-fucosyltransferase 7	0	1	0	1
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	3	1	4
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	2	3
Mitogen-activated protein kinase 14	0	3	2	5
Bcl-2-related protein A1	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	3	1	4
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	0	1
Reverse transcriptase/RNaseH	0	2	0	2
3-oxoacyl-[acyl-carrier-protein] reductase	0	1	0	1
MAP kinase-activated protein kinase 5	0	2	1	3
Histone acetyltransferase KAT2B	0	1	0	1
Bcl-2-like protein 2	0	1	0	1
Bcl2-associated agonist of cell death	0	1	0	1
Histone acetyltransferase KAT5	0	1	0	1
Enoyl-acyl-carrier protein reductase	0	2	0	2
3-oxoacyl-acyl-carrier protein reductase	0	1	0	1
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)	0	1	0	1
Bcl-2-like protein 10	0	1	0	1
Zinc finger protein mex-5	0	0	1	1
LMP1 [Human herpesvirus 4]	0	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Regulatory protein E2	0	0	1	1
ATP-dependent translocase ABCB1	0	5	0	5
DNA topoisomerase 1	0	1	0	3
DNA topoisomerase 2-alpha	0	1	3	9
DNA topoisomerase 2	0	0	0	1
ATP-dependent translocase ABCB1	0	5	0	6
Serum paraoxonase/arylesterase 1	0	3	0	3
Caspase-3	0	1	0	1
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	3	10
Tubulin beta-2B chain	0	1	0	1
Integrase	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	6	0	7
Bone morphogenetic protein receptor type-1B	0	0	2	2
Cell division cycle 7-related protein kinase	0	0	2	2
Serine/threonine-protein kinase PLK4	0	0	2	2
ATP-dependent RNA helicase DDX3X	0	0	2	2
Pyridoxal kinase	0	0	2	2
Citron Rho-interacting kinase	0	0	2	2
Serine/threonine-protein kinase Chk1	0	0	2	2
Aurora kinase A	0	0	2	2
Cyclin-G-associated kinase	0	0	2	2
Ephrin type-B receptor 6	0	0	2	2
Peroxisomal acyl-coenzyme A oxidase 3	0	0	2	2
Receptor-interacting serine/threonine-protein kinase 2	0	0	2	2
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	2	2
Dynamin-like 120 kDa protein, mitochondrial	0	0	2	2
Eukaryotic translation initiation factor 5B	0	0	2	2
Rho-associated protein kinase 2	0	0	2	2
Serine/threonine-protein kinase ULK1	0	0	2	2
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	2	2
Ribosomal protein S6 kinase alpha-5	0	0	2	2
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	2	2
Ribosomal protein S6 kinase alpha-4	0	0	2	2
Serine/threonine-protein kinase 16	0	0	2	2
Serine/threonine-protein kinase 10	0	0	2	2
Serine/threonine-protein kinase D3	0	0	2	2
Structural maintenance of chromosomes protein 2	0	0	2	2
Mitogen-activated protein kinase kinase kinase 6	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	2	2
Serine/threonine-protein kinase LATS1	0	0	2	2
Serine/threonine-protein kinase PAK 4	0	0	2	2
Tyrosine-protein kinase ABL1	0	1	3	4
Epidermal growth factor receptor	0	0	2	2
High affinity nerve growth factor receptor	0	0	2	2
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	1	1
ADP/ATP translocase 2	0	0	2	2
Protein kinase C beta type	0	0	2	2
Insulin receptor	0	0	2	2
Tyrosine-protein kinase Lck	0	0	2	2
Tyrosine-protein kinase Fyn	0	0	2	2
Cyclin-dependent kinase 1	0	0	2	2
Glycogen phosphorylase, liver form	0	0	2	2
Tyrosine-protein kinase Fes/Fps	0	0	2	2
Adenine phosphoribosyltransferase	0	0	2	2
Tyrosine-protein kinase Yes	0	0	2	2
Tyrosine-protein kinase Lyn	0	0	2	2
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	2	2
Insulin-like growth factor 1 receptor	0	0	2	2
Signal recognition particle receptor subunit alpha	0	0	2	2
Cytochrome c1, heme protein, mitochondrial	0	0	2	2
Tyrosine-protein kinase HCK	0	0	2	2
Platelet-derived growth factor receptor beta	0	0	2	2
Tyrosine-protein kinase Fgr	0	0	2	2
Serine/threonine-protein kinase A-Raf	0	0	2	2
Glycogen phosphorylase, brain form	0	0	2	2
Breakpoint cluster region protein	0	0	3	3
Serine/threonine-protein kinase pim-1	0	0	2	2
Fibroblast growth factor receptor 1	0	0	2	2
Cyclin-dependent kinase 4	0	0	2	2
ADP/ATP translocase 3	0	0	2	2
Inosine-5'-monophosphate dehydrogenase 2	0	0	2	2
Proto-oncogene tyrosine-protein kinase Src	0	0	2	2
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	2	2
Serine/threonine-protein kinase B-raf	0	1	2	3
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	2	2
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	2	4
Tyrosine-protein kinase Fer	0	0	2	2
Protein kinase C alpha type	0	0	2	2
cAMP-dependent protein kinase catalytic subunit alpha	0	0	2	2
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	2	2
Casein kinase II subunit alpha'	0	0	2	2
Ras-related protein Rab-6A	0	0	2	2
Ephrin type-A receptor 1	0	0	2	2
Multifunctional protein ADE2	0	0	2	2
cAMP-dependent protein kinase catalytic subunit gamma	0	0	1	1
cAMP-dependent protein kinase catalytic subunit beta	0	0	2	2
Ferrochelatase, mitochondrial	0	0	2	2
Ribosomal protein S6 kinase beta-1	0	0	2	2
Tyrosine-protein kinase JAK1	0	0	2	2
Cyclin-dependent kinase 2	0	0	2	2
Beta-adrenergic receptor kinase 1	0	0	2	2
Probable ATP-dependent RNA helicase DDX6	0	0	2	2
Mitogen-activated protein kinase 3	0	0	2	2
MAP/microtubule affinity-regulating kinase 3	0	0	2	2
Deoxycytidine kinase	0	0	2	2
Mitogen-activated protein kinase 1	0	2	2	4
Ephrin type-A receptor 2	0	0	2	2
Ephrin type-B receptor 2	0	0	2	2
Non-receptor tyrosine-protein kinase TYK2	0	0	2	2
UMP-CMP kinase	0	0	2	2
Phosphatidylethanolamine-binding protein 1	0	0	2	2
Wee1-like protein kinase	0	0	2	2
Heme oxygenase 2	0	0	2	2
S-adenosylmethionine synthase isoform type-2	0	0	2	2
DnaJ homolog subfamily A member 1	0	0	2	2
RAC-alpha serine/threonine-protein kinase	0	1	2	3
RAC-beta serine/threonine-protein kinase	0	0	2	2
Dual specificity protein kinase TTK	0	0	2	2
DNA replication licensing factor MCM4	0	0	2	2
Myosin-10	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 2	0	1	2	3
Receptor-type tyrosine-protein kinase FLT3	0	0	2	2
Bone morphogenetic protein receptor type-1A	0	0	2	2
Activin receptor type-1B	0	0	2	2
TGF-beta receptor type-1	0	0	2	2
TGF-beta receptor type-2	0	0	2	2
Electron transfer flavoprotein subunit beta	0	0	2	2
Tyrosine-protein kinase CSK	0	0	2	2
Glycine--tRNA ligase	0	0	2	2
Protein kinase C iota type	0	0	2	2
Exosome RNA helicase MTR4	0	0	2	2
Serine/threonine-protein kinase mTOR	0	3	2	5
Tyrosine-protein kinase Tec	0	0	2	2
Tyrosine-protein kinase ABL2	0	0	2	2
Tyrosine-protein kinase FRK	0	0	2	2
G protein-coupled receptor kinase 6	0	0	2	2
Tyrosine-protein kinase SYK	0	0	2	2
26S proteasome regulatory subunit 6B	0	0	2	2
Mitogen-activated protein kinase 8	0	0	2	2
Mitogen-activated protein kinase 9	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 3	0	0	2	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	2	2
Casein kinase I isoform alpha	0	0	2	2
Casein kinase I isoform delta	0	0	2	2
MAP kinase-activated protein kinase 2	0	0	2	2
Elongation factor Tu, mitochondrial	0	0	2	2
Choline-phosphate cytidylyltransferase A	0	0	2	2
Cysteine--tRNA ligase, cytoplasmic	0	0	2	2
Casein kinase I isoform epsilon	0	0	2	2
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	2	2
Dual specificity protein kinase CLK1	0	0	2	2
Dual specificity protein kinase CLK2	0	0	2	2
Dual specificity protein kinase CLK3	0	0	2	2
Glycogen synthase kinase-3 alpha	0	0	2	2
Cyclin-dependent kinase 7	0	0	2	2
Cyclin-dependent kinase 9	0	0	2	2
Ras-related protein Rab-27A	0	0	2	2
Interleukin-1 receptor-associated kinase 1	0	0	2	2
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Ribosomal protein S6 kinase alpha-3	0	0	2	2
Serine/threonine-protein kinase Nek2	0	0	2	2
Serine/threonine-protein kinase Nek3	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 6	0	0	2	2
Serine/threonine-protein kinase PLK1	0	0	2	2
LIM domain kinase 1	0	0	2	2
LIM domain kinase 2	0	0	2	2
Mitogen-activated protein kinase 10	0	0	2	2
Tyrosine--tRNA ligase, cytoplasmic	0	0	2	2
5'-AMP-activated protein kinase subunit gamma-1	0	0	2	2
Ephrin type-B receptor 3	0	0	2	2
Ephrin type-A receptor 5	0	0	2	2
Ephrin type-B receptor 4	0	0	2	2
Ephrin type-A receptor 4	0	0	2	2
Adenylate kinase 2, mitochondrial	0	0	2	2
Adenosine kinase	0	0	2	2
Ras-related protein Rab-10	0	0	2	2
Actin-related protein 3	0	0	2	2
Actin-related protein 2	0	0	2	2
GTP-binding nuclear protein Ran	0	0	2	2
Casein kinase I isoform gamma-2	0	0	2	2
Cyclin-dependent kinase 3	0	0	1	1
Cyclin-dependent kinase 6	0	0	2	2
Cyclin-dependent-like kinase 5	0	0	2	2
Cyclin-dependent kinase 16	0	0	2	2
Cyclin-dependent kinase 17	0	0	2	2
ATP-dependent 6-phosphofructokinase, platelet type	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 1	0	1	2	3
Protein kinase C theta type	0	0	2	2
Activin receptor type-1	0	0	2	2
Macrophage-stimulating protein receptor	0	0	2	2
Focal adhesion kinase 1	0	0	2	2
Protein kinase C delta type	0	0	2	2
Tyrosine-protein kinase BTK	0	0	2	2
Activated CDC42 kinase 1	0	0	2	2
Epithelial discoidin domain-containing receptor 1	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	2	2
Serine/threonine-protein kinase 4	0	0	2	2
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 5	0	0	2	2
Mitogen-activated protein kinase 7	0	0	2	2
Serine/threonine-protein kinase PAK 2	0	0	2	2
Serine/threonine-protein kinase 3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 1	0	0	2	2
Integrin-linked protein kinase	0	0	2	2
Rho-associated protein kinase 1	0	0	2	2
Non-receptor tyrosine-protein kinase TNK1	0	0	2	2
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	2	2
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	2	2
Activin receptor type-2B	0	0	2	2
Bone morphogenetic protein receptor type-2	0	0	2	2
Protein-tyrosine kinase 6	0	0	2	2
cGMP-dependent protein kinase 1	0	0	2	2
Cyclin-dependent kinase 13	0	0	2	2
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	2	2
Protein-tyrosine kinase 2-beta	0	0	2	2
Maternal embryonic leucine zipper kinase	0	0	2	2
Structural maintenance of chromosomes protein 1A	0	0	2	2
Chromodomain-helicase-DNA-binding protein 4	0	0	2	2
Peroxisomal acyl-coenzyme A oxidase 1	0	0	2	2
Ephrin type-A receptor 7	0	0	1	1
Delta(24)-sterol reductase	0	0	2	2
Ribosomal protein S6 kinase alpha-1	0	0	2	2
Dual specificity testis-specific protein kinase 1	0	0	2	2
Myosin light chain kinase, smooth muscle	0	1	2	3
Mitogen-activated protein kinase 11	0	0	2	2
Serine/threonine-protein kinase STK11	0	0	2	2
Serine/threonine-protein kinase N1	0	0	2	2
Serine/threonine-protein kinase N2	0	0	2	2
Calcium/calmodulin-dependent protein kinase type IV	0	0	2	2
Mitogen-activated protein kinase kinase kinase 11	0	0	2	2
Discoidin domain-containing receptor 2	0	0	2	2
AP2-associated protein kinase 1	0	0	2	2
Myosin light chain kinase 3	0	0	2	2
Putative heat shock protein HSP 90-beta 2	0	0	2	2
Serine/threonine-protein kinase MRCK alpha	0	0	2	2
Serine/threonine-protein kinase MRCK gamma	0	0	2	2
Acyl-CoA dehydrogenase family member 10	0	0	2	2
Serine/threonine-protein kinase N3	0	0	2	2
Serine/threonine-protein kinase ULK3	0	0	2	2
Uncharacterized protein FLJ45252	0	0	2	2
Acyl-CoA dehydrogenase family member 11	0	0	2	2
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	2	2
Serine/threonine-protein kinase MARK2	0	0	2	2
ATP-dependent RNA helicase DHX30	0	0	2	2
Serine/threonine-protein kinase TAO1	0	0	2	2
STE20-related kinase adapter protein alpha	0	0	2	2
Myosin-14	0	0	2	2
AarF domain-containing protein kinase 1	0	0	2	2
ATP-dependent RNA helicase DDX42	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	2	2
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	1	1
Regulatory-associated protein of mTOR	0	2	0	2
Atypical kinase COQ8A, mitochondrial	0	0	2	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	2	2
Mitogen-activated protein kinase 15	0	0	2	2
Serine/threonine-protein kinase Nek9	0	0	2	2
Serine/threonine-protein kinase Nek7	0	0	1	1
ATP-dependent RNA helicase DDX1	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	2	2
Aurora kinase B	0	0	2	2
MAP/microtubule affinity-regulating kinase 4	0	0	2	2
Serine/threonine-protein kinase Nek1	0	0	2	2
PAS domain-containing serine/threonine-protein kinase	0	0	2	2
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	2	2
EKC/KEOPS complex subunit TP53RK	0	0	2	2
Dual specificity testis-specific protein kinase 2	0	0	2	2
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	2	2
Mitogen-activated protein kinase kinase kinase 5	0	0	2	2
Mitogen-activated protein kinase kinase kinase 3	0	0	2	2
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	2	2
Target of rapamycin complex subunit LST8	0	2	0	2
Nucleolar GTP-binding protein 1	0	0	2	2
Serine/threonine-protein kinase D2	0	0	2	2
NUAK family SNF1-like kinase 2	0	0	1	1
RNA cytidine acetyltransferase	0	0	2	2
Serine/threonine-protein kinase SIK2	0	0	2	2
STE20-like serine/threonine-protein kinase	0	0	2	2
Serine/threonine-protein kinase TAO3	0	0	2	2
dCTP pyrophosphatase 1	0	0	2	2
Dual specificity protein kinase CLK4	0	0	2	2
Casein kinase I isoform gamma-1	0	0	2	2
Phenylalanine--tRNA ligase beta subunit	0	0	2	2
BMP-2-inducible protein kinase	0	0	2	2
Obg-like ATPase 1	0	0	2	2
Midasin	0	0	2	2
Interleukin-1 receptor-associated kinase 4	0	0	2	2
Mitogen-activated protein kinase kinase kinase 20	0	0	2	2
Cyclin-dependent kinase 12	0	0	2	2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	1	1
Serine/threonine-protein kinase 26	0	0	2	2
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	2	2
Serine/threonine-protein kinase NLK	0	0	2	2
5'-AMP-activated protein kinase subunit gamma-2	0	0	2	2
Serine/threonine-protein kinase TBK1	0	0	2	2
Septin-9	0	0	2	2
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
Ribosomal protein S6 kinase alpha-6	0	0	2	2
TRAF2 and NCK-interacting protein kinase	0	0	2	2
Serine/threonine-protein kinase TAO2	0	0	2	2
Long-chain-fatty-acid--CoA ligase 5	0	0	1	1
RAC-gamma serine/threonine-protein kinase	0	0	2	2
Serine/threonine-protein kinase SIK3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 2	0	0	2	2
Thyroid hormone receptor-associated protein 3	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	2	2
Receptor-interacting serine/threonine-protein kinase 3	0	0	2	2
Serine/threonine-protein kinase MRCK beta	0	0	2	2
Interleukin-1 receptor-associated kinase 3	0	0	2	2
Casein kinase I isoform gamma-3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 4	0	0	2	2
Nuclear receptor subfamily 1 group I member 2	0	0	5	5
D(4) dopamine receptor	0	2	0	2
Delta-type opioid receptor	0	3	0	3
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	5	1	6
Kappa-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Cytochrome P450 1A2	0	2	0	2
Tryptophan 5-hydroxylase 1	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Inositol monophosphatase 1	6	0	0	6
Sigma intracellular receptor 2	0	1	0	1
Transporter	0	2	0	2
Albumin	0	1	2	7
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Adenosine receptor A1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
G-protein coupled receptor 35	0	1	1	2
Gamma-aminobutyric acid	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Sterol O-acyltransferase 1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Platelet glycoprotein VI	0	1	2	4
Gamma-aminobutyric acid receptor subunit theta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	0	1	1
Glycine receptor subunit alpha-1	0	0	2	2
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	1	1	2
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Spike glycoprotein	0	0	2	2
Transmembrane protease serine 2	0	0	2	2
Procathepsin L	0	0	2	2
Replicase polyprotein 1a	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Cyclic GMP-AMP synthase	0	1	0	1
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
Stromelysin-1	0	0	1	1
Urease subunit alpha	0	1	0	1
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Urease subunit beta	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Cytochrome P450 2C8	0	2	0	3
Mast/stem cell growth factor receptor Kit	0	1	1	2
Platelet-derived growth factor receptor alpha	0	1	1	2
Cytochrome P450 3A5	0	1	0	2
Beta-adrenergic receptor kinase 1	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	5	0	0	5
Chain A, Acetylcholinesterase	0	1	0	1
interferon gamma precursor	0	0	0	1
Acetylcholinesterase	0	1	0	1
Liver carboxylesterase 1	0	0	0	2
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
Ornithine decarboxylase	0	0	0	2
Adenosine receptor A3	0	8	1	9
Retinoic acid receptor alpha	0	2	2	4
Retinoic acid receptor gamma	0	2	2	4
Retinoic acid receptor beta	0	2	2	4
Cellular retinoic acid-binding protein 2	0	0	2	2
Retinoic acid receptor RXR-alpha	0	2	2	4
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	2	0	3
Cellular retinoic acid-binding protein 1	0	0	2	2
Rap guanine nucleotide exchange factor 4	2	0	0	2
tyrosine-protein kinase Yes	1	0	0	1
Fatty-acid amide hydrolase 1	0	2	0	2
Monoglyceride lipase	0	1	0	1
Fatty-acid amide hydrolase 1	0	2	0	2
Monoglyceride lipase	0	1	0	1
Monoglyceride lipase	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	2	0	2
Gonadotropin-releasing hormone receptor	0	1	0	1
Gonadotropin-releasing hormone receptor	0	2	0	2
Chain A, protease	0	1	0	1
Chain B, protease	0	1	0	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, PROTEASE RETROPEPSIN	0	1	0	1
Chain B, PROTEASE RETROPEPSIN	0	1	0	1
Chain A, Protease Retropepsin	0	1	0	1
Chain B, Protease Retropepsin	0	1	0	1
Chain A, Protease Retropepsin	0	1	0	1
Chain B, Protease Retropepsin	0	1	0	1
Gag-Pol polyprotein	0	2	0	2
Gag-Pol polyprotein	0	2	0	2
Gag-Pol polyprotein	0	2	0	2
Gag-Pol polyprotein	0	2	0	2
Gag-Pol polyprotein	0	2	0	2
Protease	0	3	2	7
CAAX prenyl protease 1 homolog	0	1	0	1
Plasmepsin V	0	2	0	2
Protease	0	4	3	7
Neprilysin	0	1	0	1
Thromboxane A2 receptor	0	1	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Type-1 angiotensin II receptor	0	1	1	2
Squalene synthase	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Type-1 angiotensin II receptor	0	1	1	2
Solute carrier organic anion transporter family member 1B1	0	7	0	9
M-phase phosphoprotein 8	4	0	0	4
Myeloperoxidase	0	1	0	1
Cytochrome P450 2C11	0	1	0	1
Aromatase	0	1	0	1
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Cytochrome P450 1B1	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Histamine H3 receptor	0	2	0	2
Sodium-dependent dopamine transporter	0	2	0	2
Glucocorticoid receptor	0	4	1	10
Glycine receptor subunit alpha-1	0	4	0	4
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Translocator protein	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
Equilibrative nucleoside transporter 1	0	1	0	1
B2 bradykinin receptor	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	1	0	1
Quinolone resistance protein NorA	0	1	0	1
Adenosine receptor A3	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	6	0	7
Transient receptor potential cation channel subfamily A member 1	0	0	2	2
hypothetical protein, conserved	1	0	0	1
beta-2 adrenergic receptor	2	0	0	2
tumor necrosis factor	1	0	0	1
eyes absent homolog 2 isoform a	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	4	0	4
Glutathione reductase, mitochondrial	0	2	0	2
Phospholipase A2, membrane associated	0	0	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Thromboxane-A synthase	0	2	0	2
Platelet-activating factor receptor	0	0	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Adenosine receptor A1	0	4	0	4
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
C-C chemokine receptor type 2	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	4	0	4
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Leukotriene B4 receptor 1	0	0	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Beta-2 adrenergic receptor	0	1	1	4
Indoleamine 2,3-dioxygenase 2	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Leukotriene B4 receptor 2	0	0	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Neuraminidase	0	2	0	2
Neuraminidase	0	2	0	2
Neuraminidase	0	2	0	2
Neuraminidase	0	2	0	2
Neuraminidase	0	1	0	1
Neuraminidase	0	2	0	2
Sialidase	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Neuraminidase	0	2	0	2
Neuraminidase	0	2	0	2
Neuraminidase	0	1	0	1
Neuraminidase	0	1	0	1
Sialidase-4	0	1	0	1
Sialidase-1	0	1	0	1
Sialidase-3	0	1	0	1
Sialidase-2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
MBT domain-containing protein 1	0	1	0	1
Lethal(3)malignant brain tumor-like protein 4	0	1	0	1
Muscarinic acetylcholine receptor	0	0	1	1
Lethal(3)malignant brain tumor-like protein 3	0	1	0	1
Lethal(3)malignant brain tumor-like protein 1	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	2	2	4
Vasopressin V1a receptor	0	1	0	1
Vasopressin V1a receptor	0	5	2	7
Vasopressin V1b receptor	0	1	1	2
Vasopressin V1b receptor	0	1	0	1
Oxytocin receptor	0	1	0	1
Oxytocin receptor	0	0	1	1
Vasopressin V2 receptor	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	1	0	1
Farnesyl pyrophosphate synthase	0	1	0	1
Alpha-1B adrenergic receptor	0	0	1	1
Beta-1 adrenergic receptor	0	2	2	4
Beta-3 adrenergic receptor	0	2	2	4
POU domain, class 2, transcription factor 1	0	0	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	0	0	1
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Beta-1 adrenergic receptor	0	1	1	3
Endothelin-1 receptor	0	1	1	2
5-hydroxytryptamine receptor 1B	0	2	1	3
Neuromedin-K receptor	0	0	1	1
Cholecystokinin receptor type A	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Albumin	0	0	1	1
5-hydroxytryptamine receptor 7	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
D(2) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Chain A, HIV-1 PROTEASE	0	1	0	1
Chain B, HIV-1 PROTEASE	0	1	0	1
Chain A, POL polyprotein	0	1	0	1
Chain B, POL polyprotein	0	1	0	1
Chain A, POL polyprotein	0	1	0	1
Chain B, POL polyprotein	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
alpha-galactosidase	1	0	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Gag-Pol polyprotein	0	1	0	1
Substance-K receptor	0	2	0	2
Thromboxane-A synthase	0	0	0	1
Pyruvate kinase PKM	0	0	1	1
Neutral amino acid transporter A	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Tyrosine-protein kinase JAK2	0	0	1	1
Cyclin-dependent kinase-like 5	0	0	1	1
Eukaryotic translation initiation factor 4E	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
Serine/threonine-protein kinase receptor R3	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Protein kinase C zeta type	0	0	1	1
Cyclin-dependent kinase 18	0	0	1	1
Tyrosine-protein kinase Mer	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Uncharacterized aarF domain-containing protein kinase 5	0	0	1	1
Programmed cell death protein 4	0	0	1	1
Misshapen-like kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1G	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Isoleucine--tRNA ligase, mitochondrial	0	0	1	1
Serine/threonine-protein kinase ICK	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	1	1
Serine/threonine-protein kinase 24	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Solute carrier organic anion transporter family member 1A4	0	1	0	3
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Thyroid hormone receptor alpha	0	2	3	5
Thyroid hormone receptor beta	0	2	3	5
Proliferating cell nuclear antigen	0	2	0	2
Peroxisome proliferator-activated receptor gamma	0	0	4	4
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	2
Solute carrier organic anion transporter family member 1A3	0	0	0	2
Solute carrier organic anion transporter family member 4C1	0	1	0	2
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Ornithine decarboxylase	0	0	0	1
Retinoic acid receptor alpha	0	2	2	7
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor gamma	0	2	2	7
Retinoic acid receptor RXR-beta	0	2	2	4
Nuclear receptor ROR-alpha	0	1	0	1
Retinoic acid receptor RXR-gamma	0	2	2	4
Nuclear receptor ROR-beta	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
RAF proto-oncogene serine/threonine-protein kinase	0	1	0	1
Malate dehydrogenase	0	1	0	1
Chymotrypsinogen B	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 22 member 6	0	0	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
Glycoprotein	0	1	0	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Catechol O-methyltransferase	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Multidrug resistance-associated protein 1	0	2	1	4
Chloroquine resistance transporter	0	1	0	1
twin arginine protein translocation system - TatA protein	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Protein-arginine deiminase type-4	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(8)

Research Excerpts

Overview

Research

Studies (262)

Protein Targets (1,378)

Beuren Syndrome

Synonyms(8)

Research Excerpts

Overview

Research

Studies (262)

Drugs Studied (129)

Protein Targets (1,378)