Page last updated: 2024-09-27

Cutaneous Phaeohyphomycosis

OPPORTUNISTIC INFECTIONS caused by the dematiaceous (darkly pigmented) MITOSPORIC FUNGI of ALTERNARIA, Bipolaris, CLADOSPORIUM, Curvularia, and EXOPHIALA. These fungi have pigmented HYPHAE due to MELANIN in the cell wall. The initial subcutaneous cyst from the infection can become systemic and spread rapidly to renal, pulmonary and cerebral systems (see CEREBRAL PHAEOHYPHOMYCOSIS) in an IMMUNOCOMPROMISED HOST.

Synonyms(3)

Synonym
Phaeohyphomycosis
Cutaneous Phaeohyphomycosis
Subcutaneous Phaeohyphomycosis

Research Excerpts

Overview

ExcerptReference
"Subcutaneous phaeohyphomycosis is the most common variety of phaeohyphomycosis and presents as asymptomatic or mildly painful, localized cysts, abscesses, or sometimes chromoblastomycosis-like lesions over the feet, legs, or hands in about 60-85% of cases."( Abhinav, C; Chauhan, PS; Mahajan, VK; Mehta, KS; Sharma, V; Thakur, K, 2013)
"Phaeohyphomycosis is a heterogeneous group of opportunistic infections caused by dematiaceous molds, which are distributed worldwide as plant pathogens but rarely cause human diseases."( Anwar, K; Khan, RU; Muhammad, K; Raza, H, 2015)
"PurposePhaeohyphomycosis are melanin-containing fungi that rarely infect the eye."( Johnson, Z; Maudgil, A; Mudhar, HS; Rogers, N, 2016)
"Phaeohyphomycosis is caused by a heterogeneous group of mycelial dematiaceous (phaeoid) fungi, which produce melanin pigment."( Chander, J; Chowdhary, A; Handa, U; Kundu, R; Singla, N, 2017)
"Phaeohyphomycosis is an infection caused by a heterogeneous group of melanized fungi."( Chen, CB; de Hoog, S; Lee, YY; Li, HE; Ng, CY; Sun, PL, 2017)
"Phaeohyphomycosis is an infrequent infection in human beings."( Caviedes, MP; Eliceche, ML; Galimberti, RL; Torre, AC; Valdivia Monteros, DC; Volonteri, VI, 2017)
"Phaeohyphomycosis is a fungal infection caused by heterogenous group of fungi known as phaeoid or dematiaceous fungi."( Basu, D; Bheemanati Hanuman, S; Jinkala, SR; Neelaiah, S; Singh, R; Stephen, N, 2018)
"Phaeohyphomycosis is a rare mycotic infection caused by heterogenous groups of dematiaceous fungi involving the skin and subcutaneous tissue."( Kakkar, N; Kapatia, G; Kaur, H; Pandey, T; Verma, R, 2019)
"Phaeohyphomycosis is a term used to describe a heterogenous group of cutaneous and systemic mycotic infections caused by melanized fungi."( Huang, PY; Ng, CY; Sun, PL; Wu, TS; Wu, YM; Yang, SJ, 2019)
"Disseminated phaeohyphomycosis is an extremely rare clinical syndrome, especially in a host without apparent immunological defect."( Changpradub, D; Mitthamsiri, W; Nasomsong, W; Oer-Areemitr, N; Srisuttiyakorn, C; Vasikasin, V, 2019)
"Phaeohyphomycosis is a chronic subcutaneous fungal infection caused by dematiaceous fungi, commonly involving the extremities, which present as single or multiple lesions mimicking a benign tumor."( Gochhait, D; Keloth, T; Siddaraju, N; Sivaranjani, S, 2019)
"Phaeohyphomycosis is a diverse group of uncommon mycotic infections caused by dematiaceous fungi which appears to be increasing in incidence, particularly in transplant recipients."( Baj, A; Dalla Gasperina, D; Di Rosa, Z; Grossi, PA; Lepera, V; Lombardi, D; Lombardi, G; Nava, A; Rovelli, C, 2019)
"Disseminated phaeohyphomycosis is a rare and unusual infection that can be caused by dematiaceous fungi."( Layegh, P; Razmyar, M; Taghizadeh-Armaki, M; Tayyebi Meibodi, N; Zarrinfar, H, 2020)
"Phaeohyphomycosis is a set of fungal infections caused by various dematiaceous fungi such as coelomycetes."( Denis-Musquer, M; Hartuis, S; Jeddi, F; Lavergne, RA; Le Pape, P; Muguet, L; Paugam, C; Sabou, M, 2020)
"Phaeohyphomycosis is a chronic infectious disease caused by dematiaceous fungi."( Bailly, É; Bastides, F; Bernard, L; De Muret, A; Desoubeaux, G; El Baz, Z; Garcia-Hermoso, D; Marteau, E; Mercier, V; Miquelestorena-Standley, E; Vermes, E, 2020)
"Although cases of phaeohyphomycosis are not very common, they may end fatally."( Dobiáš, R; Havlíček, V, 2020)
"CNS phaeohyphomycosis is a serious, life-threatening infection."( Boguniewicz, J; Cameron, LH; Demmler-Harrison, GJ; Dutta, A; Fogarty, T; Frontiero, J; Hunter, JV; Jarjour, IT; Lotze, TE; Ogunbona, OB; Pareek, AV; Whitehead, WE, 2022)

Treatment

ExcerptReference
"Regarding episodes of subcutaneous phaeohyphomycosis, a complete surgical excision without antifungal therapy was possible in 21 of 51 (41."( Camargo, LF; Colombo, AL; Enokihara, MM; Gonçalves, SS; Medina-Pestana, JO; Ogawa, MM; Santos, DW; Tomimori, J, 2017)

Research

Studies (101)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's76 (75.25)28.8240
2020's25 (24.75)9.53
DrugIndicatedRelationship StrengthStudiesTrials
aminolevulinic acid0low20
fluconazole0low10
flucytosine0low10
ketoconazole0low10
potassium iodide0low10
prednisolone0low20
prednisone0low20
tobramycin0low10
propiconazole0low10
itraconazole0low400
triazoles0low160
voriconazole0low300
imipenem, anhydrous0low10
methotrexate0low10
levofloxacin0low10
anidulafungin0low10
deoxycholic acid0low10
trimethoprim, sulfamethoxazole drug combination0low10
epiglucan0low20
laminaran0low10
tacrolimus0low10
posaconazole0low100
l 743,8720low30
micafungin0low10
terbinafine0low120
amphotericin b0low190
phenylephrine hydrochloride0low10
tanespimycin0low10
isavuconazole0low30
amphotericin b, deoxycholate drug combination0low10
bassianolide0low10
acyclovir0low10

Protein Targets (487)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain E, Purine nucleoside phosphorylase0101
Chain A, HADH2 protein4004
Chain B, HADH2 protein4004
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, Ferritin light chain4004
Thymidine kinase 0101
thioredoxin reductase4004
phosphopantetheinyl transferase5005
GLS protein3003
TDP1 protein120012
Smad31001
thyroid stimulating hormone receptor1001
EWS/FLI fusion protein6006
arylsulfatase A2002
euchromatic histone-lysine N-methyltransferase 26006
activating transcription factor 63003
Histone H2A.x3003
Bloom syndrome protein isoform 13003
hemoglobin subunit beta1001
atrial natriuretic peptide receptor 1 precursor1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
lamin isoform A-delta108008
Solute carrier family 22 member 1 0102
ATP-binding cassette sub-family C member 3011011
Multidrug resistance-associated protein 4011012
Solute carrier family 22 member 60001
Bile salt export pump0404
Bile salt export pump012012
Purine nucleoside phosphorylase0101
Thymidine kinase, cytosolic0001
POU domain, class 2, transcription factor 20001
Cytochrome P450 2C9 0707
Cytochrome P450 2J20202
Disintegrin and metalloproteinase domain-containing protein 171001
Purine nucleoside phosphorylase0011
Solute carrier family 22 member 60002
Thymidine kinase 0101
Solute carrier family 22 member 80002
Canalicular multispecific organic anion transporter 1011011
Thymidine kinase0101
Chain A, Beta-lactamase2002
bromodomain adjacent to zinc finger domain 2B1001
geminin9009
Gamma-aminobutyric acid receptor subunit rho-10101
Glutamate receptor 10101
Glutamate receptor 20101
Glutamate receptor 30101
Glutamate receptor ionotropic, kainate 30101
Solute carrier family 15 member 10101
Glutamate receptor 40101
Solute carrier family 15 member 10101
Solute carrier family 15 member 20101
Chain A, Cruzipain1001
interleukin 81001
glucocorticoid receptor [Homo sapiens]100010
farnesoid X nuclear receptor6006
peroxisome proliferator-activated receptor delta4004
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
tumor necrosis factor1001
vitamin D3 receptor isoform VDRA5005
nuclear factor erythroid 2-related factor 2 isoform 18008
peripheral myelin protein 226006
Cytochrome P450 1A20202
Cytochrome P450 3A409010
Cytochrome P450 2D60303
Cytochrome P450 2C190303
Nuclear receptor ROR-gamma2002
Potassium voltage-gated channel subfamily H member 20505
Aurora kinase B0101
Broad substrate specificity ATP-binding cassette transporter ABCG20506
Replicase polyprotein 1ab0101
Cytochrome P450 2C80202
Cytochrome P450 2B60202
Chain A, STEROID DELTA-ISOMERASE0011
nuclear factor erythroid 2-related factor 2 isoform 24004
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
Steroid Delta-isomerase0011
Vitamin D3 receptor0112
Ileal sodium/bile acid cotransporter0101
TAR DNA-binding protein 434004
G-protein coupled bile acid receptor 10011
Bile acid receptor0011
Chain A, BCL-2-RELATED PROTEIN A10011
acetylcholinesterase1001
GLI family zinc finger 38008
apical membrane antigen 1, AMA11001
cytochrome P450 family 3 subfamily A polypeptide 48008
retinoic acid nuclear receptor alpha variant 17007
retinoid X nuclear receptor alpha6006
pregnane X nuclear receptor9009
estrogen nuclear receptor alpha110011
G6006
cytochrome P450 2D63003
unnamed protein product0101
chromobox protein homolog 14004
transcriptional regulator ERG isoform 32002
heat shock protein HSP 90-alpha isoform 20002
DNA polymerase iota isoform a (long)4004
cytochrome P450 3A4 isoform 11001
bcl-2-like protein 11 isoform 10011
Gamma-aminobutyric acid receptor subunit pi1012
Histone deacetylase 30202
Rap guanine nucleotide exchange factor 32002
Chymotrypsinogen A0202
Beta-lactamase0202
Interferon beta8008
HLA class I histocompatibility antigen, B alpha chain 6006
Cellular tumor antigen p53110011
Steroid 17-alpha-hydroxylase/17,20 lyase0404
Heme oxygenase 1 0101
ATP-dependent translocase ABCB10303
ATP-dependent translocase ABCB10304
Lanosterol 14-alpha demethylase0134
Aromatase0404
Gamma-aminobutyric acid receptor subunit beta-11012
Cytochrome P450 11B1, mitochondrial0303
Gamma-aminobutyric acid receptor subunit delta1012
Gamma-aminobutyric acid receptor subunit gamma-21012
Cytochrome P450 11B2, mitochondrial0303
Gamma-aminobutyric acid receptor subunit alpha-51012
Gamma-aminobutyric acid receptor subunit alpha-31012
ATP-dependent translocase ABCB10303
Gamma-aminobutyric acid receptor subunit gamma-11012
Gamma-aminobutyric acid receptor subunit alpha-21012
Heme oxygenase 20101
Gamma-aminobutyric acid receptor subunit alpha-41012
Gamma-aminobutyric acid receptor subunit gamma-31012
Gamma-aminobutyric acid receptor subunit alpha-61012
Malate dehydrogenase, cytoplasmic0202
Histone deacetylase 40202
Gamma-aminobutyric acid receptor subunit alpha-11012
Gamma-aminobutyric acid receptor subunit beta-31012
Gamma-aminobutyric acid receptor subunit beta-21012
Cytochrome P450 1440033
Steroid C26-monooxygenase0033
Steroid C26-monooxygenase0033
Mycocyclosin synthase0011
Lanosterol 14-alpha demethylase0011
Lanosterol 14-alpha demethylase0011
Histone deacetylase 10202
Lanosterol 14-alpha demethylase0325
Sterol 14-alpha demethylase0033
Sterol 14-alpha demethylase0224
Histone deacetylase 70202
GABA theta subunit1012
Inositol hexakisphosphate kinase 16006
Histone deacetylase 20202
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0202
14-alpha sterol demethylase 0033
Histone deacetylase 80202
Gamma-aminobutyric acid receptor subunit epsilon1012
Histone deacetylase 60202
Histone deacetylase 90202
Histone deacetylase 50202
cytochrome P450 2C9, partial6006
heat shock protein 90, putative0002
likely tRNA 2'-phosphotransferase0101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Skn7p0001
AR protein100010
nonstructural protein 12002
heat shock protein 900011
calcineurin A1, putative0011
serine/threonine-protein kinase PLK11001
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
Beta-lactamase 0101
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase type 20001
Metallo-beta-lactamase VIM-11 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0101
Metallo-beta-lactamase VIM-19 0001
Beta-lactamase 0001
Metallo-beta-lactamase0001
Beta-lactamase 0001
potassium voltage-gated channel subfamily H member 2 isoform d3003
Beta-lactamase 0001
Beta-lactamase0001
Beta-lactamase SHV-10001
Beta-lactamase0001
Metallo-beta-lactamase type 20001
Kappa-type opioid receptor0001
Beta-lactamase TEM0001
B2 metallo-beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-130001
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-b-lactamase 0001
Beta-lactamase IMP-1 0001
BlaVIM-1 0001
Beta-lactamase 0001
Beta-lactamase 0001
Carbapenem-hydrolyzing beta-lactamase KPC0001
Histamine H3 receptor0001
Beta-lactamase class B VIM-2 0001
Beta-lactamase 0001
Beta-lactamase VIM-1 0001
Spike glycoprotein8008
hypoxia-inducible factor 1 alpha subunit2002
RAR-related orphan receptor gamma6006
Fumarate hydratase2002
GALC protein2002
estrogen receptor 2 (ER beta)5005
nuclear receptor subfamily 1, group I, member 36006
estrogen-related nuclear receptor alpha7007
polyprotein2002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
thyroid hormone receptor beta isoform 28008
heat shock protein beta-11001
Voltage-dependent calcium channel gamma-2 subunit5005
Glutamate receptor 25005
Estrogen receptor beta0101
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial0101
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial0202
Cytochrome P450 26A10101
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
3',5'-cyclic-AMP phosphodiesterase 0101
Camphor 5-monooxygenase0001
Phospholipase A2, major isoenzyme0101
Epoxide hydrolase 10001
Aldo-keto reductase family 1 member B10404
Muscarinic acetylcholine receptor M20202
Cytochrome P450 2C11 0101
Steroid 21-hydroxylase0101
Alpha-2A adrenergic receptor0404
Steroid 17-alpha-hydroxylase/17,20 lyase 0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Cholesterol side-chain cleavage enzyme, mitochondrial 0101
5-hydroxytryptamine receptor 2A0202
Indoleamine 2,3-dioxygenase 10101
Cytochrome P450 2A20101
Cytochrome P450 11B1, mitochondrial 0202
Translocator protein0101
Alpha-2B adrenergic receptor0202
Cytochrome P450 7A1 0101
Estrogen receptor0101
Substance-K receptor0202
UDP-glucuronosyltransferase 1A1 0101
Sodium-dependent noradrenaline transporter 0404
Thromboxane-A synthase 0101
Histamine H2 receptor0202
Gonadotropin-releasing hormone receptor0112
Sodium-dependent serotonin transporter0202
Type-1 angiotensin II receptor0101
Delta-type opioid receptor0202
Cytochrome P450 4F20101
Sodium-dependent dopamine transporter 0202
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0202
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0101
Sodium/bile acid cotransporter0101
Cytochrome P450 7A10101
Lanosterol 14-alpha demethylase 0202
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Chain A, 2-oxoglutarate Oxygenase3003
Replicase polyprotein 1ab0101
CAAX prenyl protease 2 isoform 20001
DNA polymerase beta2002
histone acetyltransferase KAT2A isoform 12002
streptokinase A precursor0011
Tubulin beta-4A chain0101
Tubulin beta chain0101
Tubulin alpha-3C chain0101
Tubulin alpha-1B chain0101
Tubulin alpha-4A chain0101
Tubulin beta-4B chain0101
Fatty-acid amide hydrolase 10101
DNA gyrase subunit A0101
DNA primase0101
Tubulin beta-3 chain0101
Tubulin beta-2A chain0101
Tubulin beta-8 chain0101
Tubulin alpha-3E chain0101
Tubulin alpha-1A chain0101
Multidrug and toxin extrusion protein 10101
Tubulin alpha-1C chain0101
Tubulin beta-6 chain0101
Tubulin beta-2B chain0101
Tubulin beta-1 chain0101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain B, DIHYDROFOLATE REDUCTASE0011
acid sphingomyelinase1001
dopamine D1 receptor1001
ClpP1001
15-lipoxygenase, partial1001
ATAD5 protein, partial1001
USP1 protein, partial4004
Microtubule-associated protein tau2002
aldehyde dehydrogenase 1 family, member A12002
progesterone receptor6006
67.9K protein1001
peroxisome proliferator activated receptor gamma5005
Thymidylate synthase 0101
alpha-galactosidase1001
IDH12002
Thymidylate synthase 0101
cellular tumor antigen p53 isoform a1001
polyunsaturated fatty acid lipoxygenase ALOX121001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
importin subunit beta-1 isoform 11001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
flap endonuclease 11001
snurportin-11001
DNA polymerase eta isoform 11001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
DNA polymerase kappa isoform 12002
survival motor neuron protein isoform d2002
M-phase phosphoprotein 81001
muscleblind-like protein 1 isoform 11001
caspase-1 isoform alpha precursor1001
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10112
Carbonic anhydrase 20112
Thymidylate synthase0202
Integrin beta-31001
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
Integrin alpha-IIb1001
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Solute carrier organic anion transporter family member 1A30001
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200101
Dihydrofolate reductase 0101
Solute carrier family 22 member 60101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
ATPase family AAA domain-containing protein 55005
Ataxin-25005
Solute carrier organic anion transporter family member 1B30001
Solute carrier family 22 member 110001
Protein-arginine deiminase type-40101
ATP-dependent phosphofructokinase1001
glp-1 receptor, partial2002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
thyroid stimulating hormone receptor2002
beta-2 adrenergic receptor1001
lysosomal alpha-glucosidase preproprotein1001
mu-type opioid receptor isoform MOR-10011
Vpr1001
5-hydroxytryptamine receptor 2A0011
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
Sterol 14-alpha-demethylase0022
SMAD family member 22002
SMAD family member 32002
caspase 7, apoptosis-related cysteine protease1001
caspase-31001
14-alpha sterol demethylase 0022
14-alpha sterol demethylase 0022
Carbonic anhydrase 10101
Carbonic anhydrase 40101
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase 90101
luciferase0001
aryl hydrocarbon receptor2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
v-jun sarcoma virus 17 oncogene homolog (avian)3003
nuclear receptor subfamily 1, group I, member 21001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Glucocorticoid receptor04211
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10404
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Androgen receptor0101
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Histamine H1 receptor0011
Prostaglandin G/H synthase 20101
Nociceptin receptor0011
Estrogen receptor beta0202
pregnane X receptor2002
thioredoxin glutathione reductase1001
nuclear receptor ROR-gamma isoform 14004
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
thyroid hormone receptor beta isoform a1001
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Histamine H2 receptor2002
Guanine nucleotide-binding protein G1001
Nuclear receptor subfamily 1 group I member 20011
UDP-glucuronosyltransferase 2B70001
Cytochrome P450 3A50101
UDP-glucuronosyltransferase 1A40001
Serine/threonine-protein kinase mTOR0101
Peptidyl-prolyl cis-trans isomerase FKBP1A0213
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Peptidyl-prolyl cis-trans isomerase FKBP50101
Splicing factor 3B subunit 30101
Solute carrier organic anion transporter family member 1B10101
PPM1D protein1001
regulator of G-protein signaling 41001
Corticotropin releasing hormone receptor 20101
serine/threonine-protein kinase mTOR isoform 11001
Lysine-specific demethylase 6B0101
Lysine-specific demethylase 4B0101
ATP-dependent molecular chaperone HSP820101
Receptor tyrosine-protein kinase erbB-20101
Heat shock protein HSP 90-alpha0325
Heat shock protein HSP 90-beta0226
Breakpoint cluster region protein0101
Cholesteryl ester transfer protein0011
ATP-dependent molecular chaperone HSC820101
Lysine-specific demethylase 5A0101
Endoplasmin0112
DNA-dependent protein kinase catalytic subunit0101
Heat shock protein 75 kDa, mitochondrial0101
Heat-shock protein0101
Putative heat shock protein HSP 90-alpha A40101
Lysine-specific demethylase 4C0101
cystic fibrosis transmembrane conductance regulator0101
C-8 sterol isomerase0101
Squalene monooxygenase 0101
Squalene monooxygenase0202
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Sigma non-opioid intracellular receptor 10202
Protein Rev 0011
mitogen-activated protein kinase 11001
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Cholesterol side-chain cleavage enzyme, mitochondrial 0011
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Cholesterol 24-hydroxylase0213
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]