Page last updated: 2024-08-24

triazoles and lesinurad

triazoles has been researched along with lesinurad in 75 studies

Research

Studies (75)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's64 (85.33)24.3611
2020's11 (14.67)2.80

Authors

AuthorsStudies
Baumgartner, S; Fleischmann, R; Hingorani, V; Kerr, B; Manhard, K; Miner, JN; Polvent, E; Quart, B; Shen, Z; Suster, M; Yeh, LT1
Edwards, NL; So, A1
Jansen, TL1
Diaz-Torné, C; Perez-Herrero, N; Perez-Ruiz, F1
Hingorani, V; Kerr, B; Manhard, K; Quart, B; Rowlings, C; Shen, Z; Storgard, C; Yeh, LT1
Cravets, M; Miner, JN; Perez-Ruiz, F; Storgard, C; Sundy, JS1
Hoy, SM1
Gillen, M; Kerr, B; Shen, Z; Wallach, K; Yeh, LT; Zhu, N1
Keenan, RT; Schlesinger, N1
Schulze-Koops, H; Witt, M1
Adler, S; Baumgartner, S; Becker, MA; Bhakta, N; Fitz-Patrick, D; Fung, M; Kopicko, J; Saag, KG; Storgard, C1
Girardet, JL; Hagerty, DT; Hyndman, D; Iverson, C; Liu, S; Manhard, K; Miner, JN; Nanavati, P; Quart, B; Shen, Z; Tan, PK; Terkeltaub, R; Yeh, LT1
Hawkes, N1
Adler, S; Bardin, T; Baumgartner, S; Bhakta, N; Fung, M; Keenan, RT; Khanna, PP; Kopicko, J; So, A; Storgard, C1
Gillen, M; Harmon, E; Kerr, B; Lee, CA; Nguyen, M; Shen, Z; Tieu, K; Wilson, DM1
Gillen, M; Kerr, B; Lee, CA; Shen, Z; Valdez, S; Zhou, D1
Saag, KG1
Abeles, AM1
Singh, JA2
Gillen, M; Kerr, B; Lee, C; Shen, Z; Valdez, S; Wilson, D; Yang, C1
Bucci, G; Gillen, M; Kerr, B; Lee, C; Shen, Z; Tieu, K; Wilson, D1
Deeks, ED1
Finn, LA; Hussar, DA1
Hussar, DA1
Adler, S; Baumgartner, S; Bhakta, N; Dalbeth, N; Fung, M; Jones, G; Khanna, D; Kopicko, J; Perez-Ruiz, F; Storgard, C; Terkeltaub, R1
Hill-McManus, D; Hughes, D; Lane, S; Marshall, S; Soto, E2
Schechter, B; Valiyil, R1
Cao, Y; Chen, J; Dong, S; Fu, W; Li, H; Pang, J; Tian, Y; Wu, T; Xi, B; Zhou, P1
Adler, S; Alten, R; Baumgartner, S; Bhakta, N; Dalbeth, N; Fung, M; Kopicko, J; Saag, K; Storgard, C; Tausche, AK1
Dalbeth, N; Robinson, PC1
Day, R; Jones, G; Panova, E1
Abhishek, A1
Cai, W; Liu, W; Liu, Y; Tang, L; Wang, J; Wu, J; Xie, Y; Xu, W; Zhang, S; Zhao, G1
Abdelazim, AH; Attia, KAM; El-Abasawi, NM; El-Olemy, A1
Cano, AJ; Fente, G; Fenton, SN; Haber, SL; Vu, K; Walker, EP; Weaver, BM1
Aksenov, S; Eriksson, UG; Peck, CC; Stanski, DR1
Kuehn, BM1
Basile, M; Cicchetti, A; Drago, C; Rolli, FR; Ruggeri, M1
On, PC1
Baumgartner, S; Kerr, B; Manhard, K; Quart, B; Shen, Z; Yeh, LT1
Bly, CA; Cinfio, FN; Kabadi, S; Klein, RW; Szymanski, KA; Taylor, DC1
Chen, R; Du, Z; Jia, Z; Liu, J; Sun, J; Wang, K; Xin, Y; Xu, Q; Xu, T; Zhang, C1
Gillen, M; Hall, J; Ito, Y; Liu, S; Shen, Z; Shiramoto, M; Yamamoto, A; Yan, X1
Čápová, A; Meloun, M; Pekárek, T; Pilařová, L1
Gillen, M; Hall, J; Kerr, BM; Lee, CA; Shah, V; Shen, Z; Tieu, K; Wilson, DM; Yang, C1
Baumgartner, S; Goldfarb, DS; Jalal, D; Pillinger, M; Saag, KG; Schechter, BM; Terkeltaub, R; Valiyil, R; White, WB1
Gellrich, L; Goebel, T; Heering, J; Heitel, P; Kahnt, A; Merk, D; Proschak, E; Schubert-Zsilavecz, M1
Jansen, TL; Perez-Ruiz, F; Richette, P; Tausche, AK1
Chang, YS; Chang, YT; Lee, CH; Lin, YC; Loh, EW; Tam, KW; Wu, JY; Wu, MY1
Robinson, PC1
Girardet, JL; Lee, CA; Miner, JN; Renner, M; Shen, Z; Wilson, DM; Yang, C; Zhou, D1
Fields, TR1
Bartsch, LA; Castillo-Rodriguez, E; Fernandez-Prado, R; Kanbay, M; Ortiz, A; Perez-Gomez, MV1
Baumgartner, S; Dalbeth, N; Fung, M; Jones, G; Khanna, D; Perez-Ruiz, F; Terkeltaub, R1
Gillen, M; Kerr, B; Lee, CA; Shen, Z; Valdez, S; Wallach, K; Wilson, DM1
Gupta, MK; Singh, JA1
Alam, O; Ezzeldin, E; Herqash, RN; Iqbal, M1
Lee, YH; Song, GG1
Oyagüez, I; Pérez-Ruiz, F; Presa, M1
Nguyen, M; Sun, L; Wilson, DM; Yeh, LT; Zhou, D1
Alghamdi, YS; Nassan, MA; Soliman, MM1
Abdelazim, AH; Attia, KAM; El-Olemy, A; Hasan, MA; Omar, MKM; Ramzy, S; Shahin, M1
Desai, RJ; Kim, E; Kim, SC; Lii, J; Neogi, T1
Abdelazim, AH; El-Olemy, A; Mohamed, AA; Omar, MKM; Ramzy, S; Shahin, M1
Borghi, C; Cicero, AFG; Fogacci, F; Kuwabara, M1
Abdelazim, AH; Shahin, M1
Abdel Hakiem, AF; Abdel-Megied, AM; Belal, F; Magdy, G1
Bombardier, C; Edwards, CJ; Pardo Pardo, J; Sriranganathan, MK; Vinik, O1
Saeed Alghamdi, Y1
Abdelazim, AH; Ramzy, S1
Abd Elhalim, LM; Abdelazim, AH; Abourehab, MAS; Almrasy, AA; Ramzy, S1

Reviews

21 review(s) available for triazoles and lesinurad

ArticleYear
Emerging therapies for gout.
    Rheumatic diseases clinics of North America, 2014, Volume: 40, Issue:2

    Topics: Acetamides; Adrenocorticotropic Hormone; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Benzodiazepines; Febuxostat; Gout; Gout Suppressants; Humans; Imino Furanoses; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Melanocortins; Phenylacetates; Polyethylene Glycols; Pyrimidinones; Recombinant Fusion Proteins; Thiazoles; Thioglycolates; Triazoles; Urate Oxidase; Uricosuric Agents

2014
New medications in development for the treatment of hyperuricemia of gout.
    Current opinion in rheumatology, 2015, Volume: 27, Issue:2

    Topics: Acetamides; Drug Design; Gout; Gout Suppressants; Humans; Hyperuricemia; Imino Furanoses; Molecular Targeted Therapy; Phenylacetates; Pyrimidinones; Thioglycolates; Triazoles; Uricosuric Agents

2015
Lesinurad: First Global Approval.
    Drugs, 2016, Volume: 76, Issue:4

    Topics: Clinical Trials as Topic; Enzyme Inhibitors; Gout; Humans; Hyperuricemia; Thioglycolates; Triazoles; Uricosuric Agents; Xanthine Oxidase

2016
New and Pipeline Drugs for Gout.
    Current rheumatology reports, 2016, Volume: 18, Issue:6

    Topics: Anti-Inflammatory Agents; Biological Products; Cysteine; Drug Discovery; Gout; Gout Suppressants; Humans; Interleukin-1beta; Thioglycolates; Triazoles

2016
[Hyperuricemia and gout : New aspects of an old disease].
    Der Internist, 2016, Volume: 57, Issue:7

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Gouty; Diagnosis, Differential; Evidence-Based Medicine; Gout Suppressants; Humans; Hyperuricemia; Radiography, Dual-Energy Scanned Projection; Thioglycolates; Treatment Outcome; Triazoles; Uricosuric Agents

2016
Lesinurad (Zurampic) for gout-associated hyperuricemia.
    The Medical letter on drugs and therapeutics, 2016, Nov-21, Volume: 58, Issue:1508

    Topics: Clinical Trials as Topic; Gout; Humans; Hyperuricemia; Thioglycolates; Triazoles; Uricosuric Agents; Xanthine Oxidase

2016
Lesinurad: A Review in Hyperuricaemia of Gout.
    Drugs & aging, 2017, Volume: 34, Issue:5

    Topics: Adult; Allopurinol; Drug Therapy, Combination; Enzyme Inhibitors; Febuxostat; Gout; Humans; Hyperuricemia; Kidney; Middle Aged; Organic Anion Transporters; Organic Cation Transport Proteins; Thioglycolates; Treatment Outcome; Triazoles; Uric Acid; Uricosuric Agents; Xanthine Oxidase

2017
NewDrugs 2017, part 2.
    Nursing, 2017, Volume: 47, Issue:7

    Topics: Amides; Antibodies, Monoclonal, Humanized; Benzofurans; Carbamates; Cyclopropanes; Drug Approval; Drug Therapy; gamma-Cyclodextrins; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Peptides; Phenylalanine; Quinoxalines; Sofosbuvir; Sugammadex; Sulfonamides; Sulfones; Thioglycolates; Triazoles; United States; United States Food and Drug Administration

2017
Guideline development for the management of gout: role of combination therapy with a focus on lesinurad.
    Drug design, development and therapy, 2017, Volume: 11

    Topics: Dose-Response Relationship, Drug; Drug Therapy, Combination; Gout; Gout Suppressants; Humans; Patient Selection; Practice Guidelines as Topic; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents

2017
New urate-lowing therapies.
    Current opinion in rheumatology, 2018, Volume: 30, Issue:2

    Topics: Acetamides; Drug Interactions; Enzyme Inhibitors; Gout; Gout Suppressants; Humans; Phenylacetates; Probenecid; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents

2018
Lesinurad: A Novel Agent for Management of Chronic Gout.
    The Annals of pharmacotherapy, 2018, Volume: 52, Issue:7

    Topics: Drug Interactions; Gout; Gout Suppressants; Humans; Randomized Controlled Trials as Topic; Thioglycolates; Triazoles

2018
Lesinurad (Zurampic) for Gout.
    American family physician, 2018, Mar-15, Volume: 97, Issue:6

    Topics: Drug Evaluation; Gout; Gout Suppressants; Humans; Thioglycolates; Triazoles

2018
International position paper on the appropriate use of uricosurics with the introduction of lesinurad.
    Clinical rheumatology, 2018, Volume: 37, Issue:12

    Topics: Benzbromarone; Europe; Febuxostat; Gout; Humans; International Cooperation; Practice Guidelines as Topic; Probenecid; Rheumatology; Thioglycolates; Triazoles; Uricosuric Agents; Xanthine Oxidase

2018
Efficacy and Safety of Lesinurad in Patients with Hyperuricemia Associated with Gout: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Pharmacotherapy, 2018, Volume: 38, Issue:11

    Topics: Gout; Humans; Hyperuricemia; Randomized Controlled Trials as Topic; Thioglycolates; Triazoles; Uricosuric Agents

2018
Gout - An update of aetiology, genetics, co-morbidities and management.
    Maturitas, 2018, Volume: 118

    Topics: Allopurinol; Chronic Disease; Comorbidity; Diet; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Probenecid; Thioglycolates; Triazoles; Uric Acid

2018
The Challenges of Approaching and Managing Gout.
    Rheumatic diseases clinics of North America, 2019, Volume: 45, Issue:1

    Topics: Acetamides; Allopurinol; Antibodies, Monoclonal, Humanized; Colchicine; Diet Therapy; Febuxostat; Gout; Gout Suppressants; Humans; Medication Adherence; Patient Education as Topic; Phenylacetates; Polyethylene Glycols; Quality of Health Care; Rheumatology; Thioglycolates; Triazoles; Urate Oxidase; Uric Acid

2019
Potential Dangers of Serum Urate-Lowering Therapy.
    The American journal of medicine, 2019, Volume: 132, Issue:4

    Topics: Cardiovascular Diseases; Gout Suppressants; Humans; Oxidative Stress; Polyethylene Glycols; Thioglycolates; Triazoles; Urate Oxidase; Uric Acid; Xanthine Oxidase

2019
Cardiovascular Disease in Gout and the Protective Effect of Treatments Including Urate-Lowering Therapy.
    Drugs, 2019, Volume: 79, Issue:5

    Topics: Allopurinol; Anti-Inflammatory Agents; Cardiovascular Diseases; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Thioglycolates; Treatment Outcome; Triazoles; Uric Acid

2019
Comparative efficacy and safety of lesinurad 200 mg and 400 mg combined with a xanthine oxidase inhibitor in hyperuricemic patients with gout: A Bayesian network meta-analysis of randomized controlled trials
.
    International journal of clinical pharmacology and therapeutics, 2019, Volume: 57, Issue:7

    Topics: Bayes Theorem; Drug Therapy, Combination; Gout; Humans; Network Meta-Analysis; Randomized Controlled Trials as Topic; Thioglycolates; Triazoles; Uric Acid; Xanthine Oxidase

2019
Therapeutic Strategies for the Treatment of Chronic Hyperuricemia: An Evidence-Based Update.
    Medicina (Kaunas, Lithuania), 2021, Jan-10, Volume: 57, Issue:1

    Topics: Acetamides; Allopurinol; Benzbromarone; Chronic Disease; Evidence-Based Medicine; Febuxostat; Gout Suppressants; Humans; Hyperuricemia; Naphthalenes; Nitriles; Phenylacetates; Polyethylene Glycols; Probenecid; Propionates; Pyridines; Thioglycolates; Triazoles; Urate Oxidase; Uricosuric Agents; Xanthine Oxidase

2021
Interventions for tophi in gout.
    The Cochrane database of systematic reviews, 2021, 08-11, Volume: 8

    Topics: Allopurinol; Febuxostat; Gout; Gout Suppressants; Humans; Polyethylene Glycols; Randomized Controlled Trials as Topic; Thioglycolates; Triazoles; Urate Oxidase

2021

Trials

16 trial(s) available for triazoles and lesinurad

ArticleYear
Pharmacodynamic, pharmacokinetic and tolerability evaluation of concomitant administration of lesinurad and febuxostat in gout patients with hyperuricaemia.
    Rheumatology (Oxford, England), 2014, Volume: 53, Issue:12

    Topics: Adult; Aged; Colchicine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Thiazoles; Thioglycolates; Triazoles; Uric Acid

2014
Pharmacokinetics, pharmacodynamics, and safety of lesinurad, a selective uric acid reabsorption inhibitor, in healthy adult males.
    Drug design, development and therapy, 2015, Volume: 9

    Topics: Administration, Oral; Adolescent; Adult; Biological Availability; Capsules; Cross-Over Studies; Double-Blind Method; Gastrointestinal Absorption; Healthy Volunteers; Humans; Male; Organic Anion Transporters; Organic Cation Transport Proteins; Pharmaceutical Solutions; Renal Elimination; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents; Young Adult

2015
Lesinurad in combination with allopurinol: results of a phase 2, randomised, double-blind study in patients with gout with an inadequate response to allopurinol.
    Annals of the rheumatic diseases, 2016, Volume: 75, Issue:6

    Topics: Adult; Allopurinol; Double-Blind Method; Drug Therapy, Combination; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Thioglycolates; Treatment Outcome; Triazoles

2016
Lesinurad Combined With Allopurinol: A Randomized, Double-Blind, Placebo-Controlled Study in Gout Patients With an Inadequate Response to Standard-of-Care Allopurinol (a US-Based Study).
    Arthritis & rheumatology (Hoboken, N.J.), 2017, Volume: 69, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Double-Blind Method; Drug Combinations; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Thioglycolates; Triazoles; United States; Uricosuric Agents; Young Adult

2017
Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney.
    Arthritis research & therapy, 2016, 10-03, Volume: 18, Issue:1

    Topics: Cell Line; Gout; Humans; Kidney; Male; Organic Anion Transporters; Organic Cation Transport Proteins; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents

2016
Lesinurad in combination with allopurinol: a randomised, double-blind, placebo-controlled study in patients with gout with inadequate response to standard of care (the multinational CLEAR 2 study).
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Cardiovascular Diseases; Creatinine; Double-Blind Method; Drug Therapy, Combination; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Renal Insufficiency; Retreatment; Symptom Flare Up; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents; Young Adult

2017
Effects of renal function on pharmacokinetics and pharmacodynamics of lesinurad in adult volunteers.
    Drug design, development and therapy, 2016, Volume: 10

    Topics: Administration, Oral; Adult; Aged; Area Under Curve; Biological Availability; Biomarkers; Creatinine; Female; Glomerular Filtration Rate; Gout Suppressants; Humans; Kidney; Kidney Diseases; Male; Metabolic Clearance Rate; Middle Aged; Renal Elimination; Severity of Illness Index; Thioglycolates; Triazoles; Uric Acid

2016
Lesinurad, a Selective Uric Acid Reabsorption Inhibitor, in Combination With Febuxostat in Patients With Tophaceous Gout: Findings of a Phase III Clinical Trial.
    Arthritis & rheumatology (Hoboken, N.J.), 2017, Volume: 69, Issue:9

    Topics: Creatinine; Double-Blind Method; Drug Therapy, Combination; Febuxostat; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Thioglycolates; Treatment Outcome; Triazoles; Uric Acid

2017
Lesinurad monotherapy in gout patients intolerant to a xanthine oxidase inhibitor: a 6 month phase 3 clinical trial and extension study.
    Rheumatology (Oxford, England), 2017, 12-01, Volume: 56, Issue:12

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Double-Blind Method; Drug Resistance; Enzyme Inhibitors; Female; Gout; Humans; Male; Middle Aged; Thioglycolates; Treatment Outcome; Triazoles; Uricosuric Agents; Xanthine Oxidase; Young Adult

2017
Lesinurad for the treatment of hyperuricaemia in people with gout.
    Expert opinion on pharmacotherapy, 2017, Volume: 18, Issue:17

    Topics: Animals; Gout; Gout Suppressants; Haplorhini; Humans; Hyperuricemia; Thioglycolates; Triazoles

2017
The Effect of Lesinurad in Combination With Allopurinol on Serum Uric Acid Levels in Patients With Gout.
    Journal of clinical pharmacology, 2018, Volume: 58, Issue:9

    Topics: Adult; Allopurinol; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Thioglycolates; Triazoles; Uric Acid

2018
Verinurad combined with febuxostat in Japanese adults with gout or asymptomatic hyperuricaemia: a phase 2a, open-label study.
    Rheumatology (Oxford, England), 2018, 09-01, Volume: 57, Issue:9

    Topics: Administration, Oral; Adult; Aged; Benzbromarone; Dose-Response Relationship, Drug; Drug Therapy, Combination; Febuxostat; Female; Follow-Up Studies; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Organic Anion Transporters; Organic Cation Transport Proteins; Thioglycolates; Time Factors; Treatment Outcome; Triazoles; Uric Acid; Uricosuric Agents; Young Adult

2018
Metabolism and disposition of lesinurad, a uric acid reabsorption inhibitor, in humans.
    Xenobiotica; the fate of foreign compounds in biological systems, 2019, Volume: 49, Issue:7

    Topics: Adult; Biological Availability; Cytochrome P-450 CYP2C9; Humans; Infusions, Intravenous; Male; Renal Elimination; Thioglycolates; Triazoles; Uric Acid

2019
Characterization of Stereoselective Metabolism, Inhibitory Effect on Uric Acid Uptake Transporters, and Pharmacokinetics of Lesinurad Atropisomers.
    Drug metabolism and disposition: the biological fate of chemicals, 2019, Volume: 47, Issue:2

    Topics: Administration, Oral; Adult; Gout; Healthy Volunteers; HEK293 Cells; Humans; Kidney; Male; Microsomes, Liver; Middle Aged; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Renal Reabsorption; Stereoisomerism; Structure-Activity Relationship; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents; Young Adult

2019
Efficacy and safety during extended treatment of lesinurad in combination with febuxostat in patients with tophaceous gout: CRYSTAL extension study.
    Arthritis research & therapy, 2019, 01-07, Volume: 21, Issue:1

    Topics: Adult; Drug Therapy, Combination; Febuxostat; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Thioglycolates; Treatment Outcome; Triazoles; Uricosuric Agents

2019
Lesinurad: Evaluation of Pharmacokinetic and Pharmacodynamic Interactions With Warfarin in Healthy Volunteers.
    Clinical pharmacology in drug development, 2019, Volume: 8, Issue:5

    Topics: Adult; Anticoagulants; Blood Coagulation; Cytochrome P-450 CYP2C9; Drug Interactions; Gout Suppressants; Healthy Volunteers; Humans; Male; Middle Aged; Prothrombin Time; Thioglycolates; Triazoles; Vitamin K Epoxide Reductases; Warfarin; Young Adult

2019

Other Studies

38 other study(ies) available for triazoles and lesinurad

ArticleYear
Treat to target in gout by combining two modes of action.
    Rheumatology (Oxford, England), 2014, Volume: 53, Issue:12

    Topics: Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Thiazoles; Thioglycolates; Triazoles

2014
In Vitro and In Vivo Interaction Studies Between Lesinurad, a Selective Urate Reabsorption Inhibitor, and Major Liver or Kidney Transporters.
    Clinical drug investigation, 2016, Volume: 36, Issue:6

    Topics: Adolescent; Adult; Aged; Atorvastatin; Carrier Proteins; Cell Line; Diuretics; Drug Interactions; Furosemide; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Kidney; Liver; Liver-Specific Organic Anion Transporter 1; Male; Metformin; Middle Aged; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents; Young Adult

2016
European drug agency launches website giving open access to trial data.
    BMJ (Clinical research ed.), 2016, Oct-21, Volume: 355

    Topics: Access to Information; Antineoplastic Agents; Clinical Trials as Topic; Drug Industry; Europe; Gout; Gout Suppressants; Humans; Internet; Multiple Myeloma; Oligopeptides; Thioglycolates; Triazoles

2016
Supratherapeutic dose evaluation and effect of lesinurad on cardiac repolarization: a thorough QT/QTc study.
    Drug design, development and therapy, 2016, Volume: 10

    Topics: Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Europe; Female; Heart Rate; Humans; Male; Statistics as Topic; Thioglycolates; Triazoles; Uric Acid; Xanthine Oxidase

2016
Reply.
    Arthritis & rheumatology (Hoboken, N.J.), 2017, Volume: 69, Issue:5

    Topics: Allopurinol; Double-Blind Method; Gout; Humans; Thioglycolates; Triazoles

2017
Lesinurad in Combination With Allopurinol: Risk Without Reward? Comment on the Article by Saag et al.
    Arthritis & rheumatology (Hoboken, N.J.), 2017, Volume: 69, Issue:5

    Topics: Allopurinol; Double-Blind Method; Gout; Humans; Reward; Thioglycolates; Triazoles

2017
Lesinurad combination therapy with allopurinol in gout: do CLEAR studies make the treatment of gout clearer?
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:5

    Topics: Allopurinol; Double-Blind Method; Gout; Humans; Standard of Care; Thioglycolates; Triazoles

2017
Evaluation of Pharmacokinetic Interactions Between Lesinurad, a New Selective Urate Reabsorption Inhibitor, and CYP Enzyme Substrates Sildenafil, Amlodipine, Tolbutamide, and Repaglinide.
    Clinical pharmacology in drug development, 2017, Volume: 6, Issue:4

    Topics: Adult; Amlodipine; Area Under Curve; Carbamates; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Gene Expression Regulation; Healthy Volunteers; Humans; In Vitro Techniques; Male; Middle Aged; Piperidines; Sildenafil Citrate; Thioglycolates; Tolbutamide; Triazoles; Young Adult

2017
Evaluation of Pharmacokinetic Interactions Between Lesinurad, a New Selective Urate Reabsorption Inhibitor, and Commonly Used Drugs for Gout Treatment.
    Clinical pharmacology in drug development, 2017, Volume: 6, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Colchicine; Drug Administration Schedule; Drug Interactions; Female; Gout Suppressants; Humans; Hyperuricemia; Indomethacin; Male; Middle Aged; Naproxen; Thioglycolates; Treatment Outcome; Triazoles; Uricosuric Agents; Young Adult

2017
2017 New Drug Update.
    The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists, 2017, May-01, Volume: 32, Issue:5

    Topics: Anti-Inflammatory Agents; Antipsychotic Agents; Drugs, Investigational; Dry Eye Syndromes; Gout Suppressants; Humans; Hypoglycemic Agents; Insulin, Long-Acting; Peptides; Phenylalanine; Piperidines; Sulfones; Thioglycolates; Triazoles; Urea

2017
Impact of non-adherence on the safety and efficacy of uric acid-lowering therapies in the treatment of gout.
    British journal of clinical pharmacology, 2018, Volume: 84, Issue:1

    Topics: Computer Simulation; Drug Therapy, Combination; Febuxostat; Gout; Gout Suppressants; Humans; Male; Medication Adherence; Models, Biological; Risk Assessment; Thioglycolates; Treatment Outcome; Triazoles; Uric Acid; Xanthine Oxidase

2018
Response to: 'A response to Singh. "Lesinurad combination therapy with allopurinol in gout: do CLEAR studies make the treatment of gout clearer?"' by Valiyil and Schechter.
    Annals of the rheumatic diseases, 2018, Volume: 77, Issue:7

    Topics: Allopurinol; Double-Blind Method; Gout; Humans; Standard of Care; Thioglycolates; Triazoles

2018
Lesinurad combination therapy with allopurinol in gout: do CLEAR studies make the treatment of gout clearer?
    Annals of the rheumatic diseases, 2018, Volume: 77, Issue:7

    Topics: Allopurinol; Double-Blind Method; Gout; Humans; Standard of Care; Thioglycolates; Triazoles

2018
Identification and characterization of a potent and selective inhibitor of human urate transporter 1.
    Pharmacological reports : PR, 2017, Volume: 69, Issue:5

    Topics: Animals; Blood Urea Nitrogen; Cell Line; Cell Survival; Creatinine; Dogs; Humans; Hyperuricemia; Molecular Structure; Organic Anion Transporters; Organic Cation Transport Proteins; Rats; Thioglycolates; Triazoles

2017
Lesinurad/Allopurinol (Duzallo) for Gout-Associated Hyperuricemia.
    JAMA, 2018, 01-09, Volume: 319, Issue:2

    Topics: Allopurinol; Drug Combinations; Drug Interactions; Gout; Gout Suppressants; Humans; Hyperuricemia; Organic Anion Transporters; Organic Cation Transport Proteins; Thioglycolates; Triazoles; Xanthine Oxidase

2018
Systematic Structure-Activity Relationship (SAR) Exploration of Diarylmethane Backbone and Discovery of A Highly Potent Novel Uric Acid Transporter 1 (URAT1) Inhibitor.
    Molecules (Basel, Switzerland), 2018, Jan-27, Volume: 23, Issue:2

    Topics: Benzbromarone; Biological Transport, Active; Carbon Radioisotopes; Drug Design; Gene Expression; HEK293 Cells; Humans; Methane; Organic Anion Transporters; Organic Cation Transport Proteins; Structure-Activity Relationship; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents

2018
Validated Stability Indicating High Performance Liquid Chromatographic Determination of Lesinurad.
    Journal of chromatographic science, 2018, Apr-01, Volume: 56, Issue:4

    Topics: Acetonitriles; Chromatography, High Pressure Liquid; Drug Stability; Limit of Detection; Linear Models; Reproducibility of Results; Thioglycolates; Triazoles

2018
Individualized treatment strategies for hyperuricemia informed by a semi-mechanistic exposure-response model of uric acid dynamics.
    Physiological reports, 2018, Volume: 6, Issue:5

    Topics: Allopurinol; Clinical Trials as Topic; Febuxostat; Humans; Hyperuricemia; Models, Theoretical; Precision Medicine; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents

2018
Chronic Disease Approaches Needed to Curb Gout's Growing Burden.
    JAMA, 2018, Apr-03, Volume: 319, Issue:13

    Topics: Allopurinol; Chronic Disease; Diet; Drug Combinations; Febuxostat; Gout; Gout Suppressants; Healthy Lifestyle; Humans; Patient Education as Topic; Practice Guidelines as Topic; Purines; Thioglycolates; Triazoles; Uric Acid

2018
Cost-Effectiveness Analysis of Lesinurad/Allopurinol Versus Febuxostat for the Management of Gout/Hyperuricemia in Italy.
    PharmacoEconomics, 2018, Volume: 36, Issue:5

    Topics: Allopurinol; Cost-Benefit Analysis; Drug Costs; Drug Therapy, Combination; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Italy; Male; Markov Chains; Middle Aged; Models, Economic; Monte Carlo Method; Quality-Adjusted Life Years; Thioglycolates; Triazoles

2018
Budget impact of adding lesinurad for second-line treatment of gout: a US health plan perspective.
    Journal of comparative effectiveness research, 2018, Volume: 7, Issue:8

    Topics: Allopurinol; Budgets; Gout; Gout Suppressants; Humans; Markov Chains; Models, Econometric; Thioglycolates; Triazoles; United States

2018
Zurampic Protects Pancreatic β-Cells from High Uric Acid Induced-Damage by Inhibiting URAT1 and Inactivating the ROS/AMPK/ERK Pathways.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 47, Issue:3

    Topics: AMP-Activated Protein Kinases; Animals; Anion Transport Proteins; Extracellular Signal-Regulated MAP Kinases; Insulin-Secreting Cells; MAP Kinase Signaling System; Rats; Reactive Oxygen Species; Thioglycolates; Triazoles; Uric Acid

2018
Multiwavelength UV-metric and pH-metric determination of the multiple dissociation constants of the lesinurad.
    Journal of pharmaceutical and biomedical analysis, 2018, Sep-05, Volume: 158

    Topics: Chemistry, Pharmaceutical; Hydrogen-Ion Concentration; Potentiometry; Spectrophotometry, Ultraviolet; Thermodynamics; Thioglycolates; Triazoles; Uricosuric Agents

2018
Integrated safety studies of the urate reabsorption inhibitor lesinurad in treatment of gout.
    Rheumatology (Oxford, England), 2019, 01-01, Volume: 58, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Clinical Trials, Phase III as Topic; Drug Therapy, Combination; Enzyme Inhibitors; Female; Gout; Gout Suppressants; Humans; Kidney Diseases; Male; Middle Aged; Randomized Controlled Trials as Topic; Thioglycolates; Treatment Outcome; Triazoles; Uric Acid; Xanthine Oxidase; Young Adult

2019
Urate transporter inhibitor lesinurad is a selective peroxisome proliferator-activated receptor gamma modulator (sPPARγM) in vitro.
    Scientific reports, 2018, 09-10, Volume: 8, Issue:1

    Topics: 3T3 Cells; Adipocytes; Adipogenesis; Animals; Cell Differentiation; Gout; HEK293 Cells; Hep G2 Cells; Humans; Mice; Molecular Docking Simulation; PPAR gamma; Recombinant Proteins; Thioglycolates; Transfection; Triazoles; Uricosuric Agents

2018
Impact of Non-Adherence and Flare Resolution on the Cost-Effectiveness of Treatments for Gout: Application of a Linked Pharmacometric/Pharmacoeconomic Model.
    Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 2018, Volume: 21, Issue:12

    Topics: Allopurinol; Cohort Studies; Cost-Benefit Analysis; Drug Therapy, Combination; Economics, Pharmaceutical; Febuxostat; Gout; Gout Suppressants; Health Care Costs; Humans; Medication Adherence; Models, Biological; Models, Economic; Quality of Life; Quality-Adjusted Life Years; Thioglycolates; Treatment Outcome; Triazoles; United Kingdom; Uric Acid

2018
Ultra-performance hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry for simultaneous determination of allopurinol, oxypurinol and lesinurad in rat plasma: Application to pharmacokinetic study in rats.
    PloS one, 2019, Volume: 14, Issue:3

    Topics: Allopurinol; Animals; Chromatography, Liquid; Hydrophobic and Hydrophilic Interactions; Oxypurinol; Rats; Reproducibility of Results; Tandem Mass Spectrometry; Thioglycolates; Tissue Distribution; Triazoles

2019
Second-line treatment with lesinurad and allopurinol versus febuxostat for management of hyperuricemia: a cost-effectiveness analysis for Spanish patients.
    Clinical rheumatology, 2019, Volume: 38, Issue:12

    Topics: Allopurinol; Cost-Benefit Analysis; Febuxostat; Gout Suppressants; Humans; Hyperuricemia; Markov Chains; Spain; Thioglycolates; Triazoles

2019
The Effects of Special Patient Population Plasma on Pharmacokinetic Quantifications Using LC-MS/MS.
    Drug metabolism letters, 2019, Volume: 13, Issue:2

    Topics: Allopurinol; Calibration; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Hepatic Insufficiency; Humans; Kidney; Liver; Oxypurinol; Reference Standards; Renal Insufficiency; Renal Reabsorption; Reproducibility of Results; Tandem Mass Spectrometry; Thioglycolates; Triazoles; Uricosuric Agents; Verapamil

2019
Impact of Lesinurad and allopurinol on experimental Hyperuricemia in mice: biochemical, molecular and Immunohistochemical study.
    BMC pharmacology & toxicology, 2020, 02-10, Volume: 21, Issue:1

    Topics: Allopurinol; Animals; Blood Urea Nitrogen; Catalase; Drug Synergism; Glutathione Peroxidase; Gout Suppressants; Hyperuricemia; Interleukin-1beta; Kidney; Liver; Male; Mice; Thioglycolates; Triazoles; Tumor Necrosis Factor-alpha; Uric Acid; Xanthine Oxidase

2020
Application of different spectrofluorimetric methods for determination of lesinurad and allopurinol in pharmaceutical preparation and human plasma.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2021, Jan-05, Volume: 244

    Topics: Allopurinol; Calibration; Humans; Spectrometry, Fluorescence; Thioglycolates; Triazoles

2021
Trends in Utilization of Urate-Lowering Therapies Following the US Food and Drug Administration's Boxed Warning on Febuxostat.
    Arthritis & rheumatology (Hoboken, N.J.), 2021, Volume: 73, Issue:3

    Topics: Allopurinol; Cardiovascular Diseases; Cause of Death; Drug Labeling; Febuxostat; Gout; Gout Suppressants; Humans; Mortality; Polyethylene Glycols; Practice Patterns, Physicians'; Probenecid; Risk Factors; Thioglycolates; Triazoles; United States; United States Food and Drug Administration; Urate Oxidase

2021
Spectrophotometric determination of lesinurad and allopurinol in recently approved FDA pharmaceutical preparation.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2021, Feb-15, Volume: 247

    Topics: Allopurinol; Spectrophotometry; Thioglycolates; Triazoles

2021
Different chemometric assisted approaches for spectrophotometric quantitative analysis of lesinurad and allopurinol.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2021, Apr-15, Volume: 251

    Topics: Allopurinol; Least-Squares Analysis; Spectrophotometry; Thioglycolates; Triazoles

2021
A novel quality by design approach for development and validation of a green reversed-phase HPLC method with fluorescence detection for the simultaneous determination of lesinurad, febuxostat, and diflunisal: Application to human plasma.
    Journal of separation science, 2021, Volume: 44, Issue:11

    Topics: Chromatography, High Pressure Liquid; Diflunisal; Equipment Design; Febuxostat; Fluorescence; Humans; Software; Tablets; Thioglycolates; Triazoles

2021
Hepatic and Renal Impacts of Lesinurad on Experimental Hyperuricemia: Biochemical, Molecular and Pathological Investigations.
    Pakistan journal of biological sciences : PJBS, 2021, Volume: 24, Issue:7

    Topics: Animals; Humans; Hyperuricemia; Kidney; Liver; Male; Mice; Thioglycolates; Triazoles; Uricosuric Agents

2021
Spectrophotometric quantitative analysis of lesinurad using extractive acid dye reaction based on greener selective computational approach.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2022, Sep-05, Volume: 277

    Topics: Acids; Bromphenol Blue; Coloring Agents; Spectrophotometry; Thioglycolates; Triazoles

2022
Different spectrophotometric methods for simultaneous determination of lesinurad and allopurinol in the new FDA approved pharmaceutical preparation; additional greenness evaluation.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2023, Jan-15, Volume: 285

    Topics: Allopurinol; Gout; Gout Suppressants; Humans; Triazoles

2023