triazoles has been researched along with lesinurad in 75 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 64 (85.33) | 24.3611 |
| 2020's | 11 (14.67) | 2.80 |
| Authors | Studies |
|---|---|
| Baumgartner, S; Fleischmann, R; Hingorani, V; Kerr, B; Manhard, K; Miner, JN; Polvent, E; Quart, B; Shen, Z; Suster, M; Yeh, LT | 1 |
| Edwards, NL; So, A | 1 |
| Jansen, TL | 1 |
| Diaz-Torné, C; Perez-Herrero, N; Perez-Ruiz, F | 1 |
| Hingorani, V; Kerr, B; Manhard, K; Quart, B; Rowlings, C; Shen, Z; Storgard, C; Yeh, LT | 1 |
| Cravets, M; Miner, JN; Perez-Ruiz, F; Storgard, C; Sundy, JS | 1 |
| Hoy, SM | 1 |
| Gillen, M; Kerr, B; Shen, Z; Wallach, K; Yeh, LT; Zhu, N | 1 |
| Keenan, RT; Schlesinger, N | 1 |
| Schulze-Koops, H; Witt, M | 1 |
| Adler, S; Baumgartner, S; Becker, MA; Bhakta, N; Fitz-Patrick, D; Fung, M; Kopicko, J; Saag, KG; Storgard, C | 1 |
| Girardet, JL; Hagerty, DT; Hyndman, D; Iverson, C; Liu, S; Manhard, K; Miner, JN; Nanavati, P; Quart, B; Shen, Z; Tan, PK; Terkeltaub, R; Yeh, LT | 1 |
| Hawkes, N | 1 |
| Adler, S; Bardin, T; Baumgartner, S; Bhakta, N; Fung, M; Keenan, RT; Khanna, PP; Kopicko, J; So, A; Storgard, C | 1 |
| Gillen, M; Harmon, E; Kerr, B; Lee, CA; Nguyen, M; Shen, Z; Tieu, K; Wilson, DM | 1 |
| Gillen, M; Kerr, B; Lee, CA; Shen, Z; Valdez, S; Zhou, D | 1 |
| Saag, KG | 1 |
| Abeles, AM | 1 |
| Singh, JA | 2 |
| Gillen, M; Kerr, B; Lee, C; Shen, Z; Valdez, S; Wilson, D; Yang, C | 1 |
| Bucci, G; Gillen, M; Kerr, B; Lee, C; Shen, Z; Tieu, K; Wilson, D | 1 |
| Deeks, ED | 1 |
| Finn, LA; Hussar, DA | 1 |
| Hussar, DA | 1 |
| Adler, S; Baumgartner, S; Bhakta, N; Dalbeth, N; Fung, M; Jones, G; Khanna, D; Kopicko, J; Perez-Ruiz, F; Storgard, C; Terkeltaub, R | 1 |
| Hill-McManus, D; Hughes, D; Lane, S; Marshall, S; Soto, E | 2 |
| Schechter, B; Valiyil, R | 1 |
| Cao, Y; Chen, J; Dong, S; Fu, W; Li, H; Pang, J; Tian, Y; Wu, T; Xi, B; Zhou, P | 1 |
| Adler, S; Alten, R; Baumgartner, S; Bhakta, N; Dalbeth, N; Fung, M; Kopicko, J; Saag, K; Storgard, C; Tausche, AK | 1 |
| Dalbeth, N; Robinson, PC | 1 |
| Day, R; Jones, G; Panova, E | 1 |
| Abhishek, A | 1 |
| Cai, W; Liu, W; Liu, Y; Tang, L; Wang, J; Wu, J; Xie, Y; Xu, W; Zhang, S; Zhao, G | 1 |
| Abdelazim, AH; Attia, KAM; El-Abasawi, NM; El-Olemy, A | 1 |
| Cano, AJ; Fente, G; Fenton, SN; Haber, SL; Vu, K; Walker, EP; Weaver, BM | 1 |
| Aksenov, S; Eriksson, UG; Peck, CC; Stanski, DR | 1 |
| Kuehn, BM | 1 |
| Basile, M; Cicchetti, A; Drago, C; Rolli, FR; Ruggeri, M | 1 |
| On, PC | 1 |
| Baumgartner, S; Kerr, B; Manhard, K; Quart, B; Shen, Z; Yeh, LT | 1 |
| Bly, CA; Cinfio, FN; Kabadi, S; Klein, RW; Szymanski, KA; Taylor, DC | 1 |
| Chen, R; Du, Z; Jia, Z; Liu, J; Sun, J; Wang, K; Xin, Y; Xu, Q; Xu, T; Zhang, C | 1 |
| Gillen, M; Hall, J; Ito, Y; Liu, S; Shen, Z; Shiramoto, M; Yamamoto, A; Yan, X | 1 |
| Čápová, A; Meloun, M; Pekárek, T; Pilařová, L | 1 |
| Gillen, M; Hall, J; Kerr, BM; Lee, CA; Shah, V; Shen, Z; Tieu, K; Wilson, DM; Yang, C | 1 |
| Baumgartner, S; Goldfarb, DS; Jalal, D; Pillinger, M; Saag, KG; Schechter, BM; Terkeltaub, R; Valiyil, R; White, WB | 1 |
| Gellrich, L; Goebel, T; Heering, J; Heitel, P; Kahnt, A; Merk, D; Proschak, E; Schubert-Zsilavecz, M | 1 |
| Jansen, TL; Perez-Ruiz, F; Richette, P; Tausche, AK | 1 |
| Chang, YS; Chang, YT; Lee, CH; Lin, YC; Loh, EW; Tam, KW; Wu, JY; Wu, MY | 1 |
| Robinson, PC | 1 |
| Girardet, JL; Lee, CA; Miner, JN; Renner, M; Shen, Z; Wilson, DM; Yang, C; Zhou, D | 1 |
| Fields, TR | 1 |
| Bartsch, LA; Castillo-Rodriguez, E; Fernandez-Prado, R; Kanbay, M; Ortiz, A; Perez-Gomez, MV | 1 |
| Baumgartner, S; Dalbeth, N; Fung, M; Jones, G; Khanna, D; Perez-Ruiz, F; Terkeltaub, R | 1 |
| Gillen, M; Kerr, B; Lee, CA; Shen, Z; Valdez, S; Wallach, K; Wilson, DM | 1 |
| Gupta, MK; Singh, JA | 1 |
| Alam, O; Ezzeldin, E; Herqash, RN; Iqbal, M | 1 |
| Lee, YH; Song, GG | 1 |
| Oyagüez, I; Pérez-Ruiz, F; Presa, M | 1 |
| Nguyen, M; Sun, L; Wilson, DM; Yeh, LT; Zhou, D | 1 |
| Alghamdi, YS; Nassan, MA; Soliman, MM | 1 |
| Abdelazim, AH; Attia, KAM; El-Olemy, A; Hasan, MA; Omar, MKM; Ramzy, S; Shahin, M | 1 |
| Desai, RJ; Kim, E; Kim, SC; Lii, J; Neogi, T | 1 |
| Abdelazim, AH; El-Olemy, A; Mohamed, AA; Omar, MKM; Ramzy, S; Shahin, M | 1 |
| Borghi, C; Cicero, AFG; Fogacci, F; Kuwabara, M | 1 |
| Abdelazim, AH; Shahin, M | 1 |
| Abdel Hakiem, AF; Abdel-Megied, AM; Belal, F; Magdy, G | 1 |
| Bombardier, C; Edwards, CJ; Pardo Pardo, J; Sriranganathan, MK; Vinik, O | 1 |
| Saeed Alghamdi, Y | 1 |
| Abdelazim, AH; Ramzy, S | 1 |
| Abd Elhalim, LM; Abdelazim, AH; Abourehab, MAS; Almrasy, AA; Ramzy, S | 1 |
21 review(s) available for triazoles and lesinurad
| Article | Year |
|---|---|
Emerging therapies for gout.
Topics: Acetamides; Adrenocorticotropic Hormone; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Benzodiazepines; Febuxostat; Gout; Gout Suppressants; Humans; Imino Furanoses; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Melanocortins; Phenylacetates; Polyethylene Glycols; Pyrimidinones; Recombinant Fusion Proteins; Thiazoles; Thioglycolates; Triazoles; Urate Oxidase; Uricosuric Agents | 2014 |
New medications in development for the treatment of hyperuricemia of gout.
Topics: Acetamides; Drug Design; Gout; Gout Suppressants; Humans; Hyperuricemia; Imino Furanoses; Molecular Targeted Therapy; Phenylacetates; Pyrimidinones; Thioglycolates; Triazoles; Uricosuric Agents | 2015 |
Lesinurad: First Global Approval.
Topics: Clinical Trials as Topic; Enzyme Inhibitors; Gout; Humans; Hyperuricemia; Thioglycolates; Triazoles; Uricosuric Agents; Xanthine Oxidase | 2016 |
New and Pipeline Drugs for Gout.
Topics: Anti-Inflammatory Agents; Biological Products; Cysteine; Drug Discovery; Gout; Gout Suppressants; Humans; Interleukin-1beta; Thioglycolates; Triazoles | 2016 |
[Hyperuricemia and gout : New aspects of an old disease].
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Gouty; Diagnosis, Differential; Evidence-Based Medicine; Gout Suppressants; Humans; Hyperuricemia; Radiography, Dual-Energy Scanned Projection; Thioglycolates; Treatment Outcome; Triazoles; Uricosuric Agents | 2016 |
Lesinurad (Zurampic) for gout-associated hyperuricemia.
Topics: Clinical Trials as Topic; Gout; Humans; Hyperuricemia; Thioglycolates; Triazoles; Uricosuric Agents; Xanthine Oxidase | 2016 |
Lesinurad: A Review in Hyperuricaemia of Gout.
Topics: Adult; Allopurinol; Drug Therapy, Combination; Enzyme Inhibitors; Febuxostat; Gout; Humans; Hyperuricemia; Kidney; Middle Aged; Organic Anion Transporters; Organic Cation Transport Proteins; Thioglycolates; Treatment Outcome; Triazoles; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2017 |
NewDrugs 2017, part 2.
Topics: Amides; Antibodies, Monoclonal, Humanized; Benzofurans; Carbamates; Cyclopropanes; Drug Approval; Drug Therapy; gamma-Cyclodextrins; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Peptides; Phenylalanine; Quinoxalines; Sofosbuvir; Sugammadex; Sulfonamides; Sulfones; Thioglycolates; Triazoles; United States; United States Food and Drug Administration | 2017 |
Guideline development for the management of gout: role of combination therapy with a focus on lesinurad.
Topics: Dose-Response Relationship, Drug; Drug Therapy, Combination; Gout; Gout Suppressants; Humans; Patient Selection; Practice Guidelines as Topic; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents | 2017 |
New urate-lowing therapies.
Topics: Acetamides; Drug Interactions; Enzyme Inhibitors; Gout; Gout Suppressants; Humans; Phenylacetates; Probenecid; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents | 2018 |
Lesinurad: A Novel Agent for Management of Chronic Gout.
Topics: Drug Interactions; Gout; Gout Suppressants; Humans; Randomized Controlled Trials as Topic; Thioglycolates; Triazoles | 2018 |
Lesinurad (Zurampic) for Gout.
Topics: Drug Evaluation; Gout; Gout Suppressants; Humans; Thioglycolates; Triazoles | 2018 |
International position paper on the appropriate use of uricosurics with the introduction of lesinurad.
Topics: Benzbromarone; Europe; Febuxostat; Gout; Humans; International Cooperation; Practice Guidelines as Topic; Probenecid; Rheumatology; Thioglycolates; Triazoles; Uricosuric Agents; Xanthine Oxidase | 2018 |
Efficacy and Safety of Lesinurad in Patients with Hyperuricemia Associated with Gout: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Topics: Gout; Humans; Hyperuricemia; Randomized Controlled Trials as Topic; Thioglycolates; Triazoles; Uricosuric Agents | 2018 |
Gout - An update of aetiology, genetics, co-morbidities and management.
Topics: Allopurinol; Chronic Disease; Comorbidity; Diet; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Probenecid; Thioglycolates; Triazoles; Uric Acid | 2018 |
The Challenges of Approaching and Managing Gout.
Topics: Acetamides; Allopurinol; Antibodies, Monoclonal, Humanized; Colchicine; Diet Therapy; Febuxostat; Gout; Gout Suppressants; Humans; Medication Adherence; Patient Education as Topic; Phenylacetates; Polyethylene Glycols; Quality of Health Care; Rheumatology; Thioglycolates; Triazoles; Urate Oxidase; Uric Acid | 2019 |
Potential Dangers of Serum Urate-Lowering Therapy.
Topics: Cardiovascular Diseases; Gout Suppressants; Humans; Oxidative Stress; Polyethylene Glycols; Thioglycolates; Triazoles; Urate Oxidase; Uric Acid; Xanthine Oxidase | 2019 |
Cardiovascular Disease in Gout and the Protective Effect of Treatments Including Urate-Lowering Therapy.
Topics: Allopurinol; Anti-Inflammatory Agents; Cardiovascular Diseases; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Thioglycolates; Treatment Outcome; Triazoles; Uric Acid | 2019 |
Comparative efficacy and safety of lesinurad 200 mg and 400 mg combined with a xanthine oxidase inhibitor in hyperuricemic patients with gout: A Bayesian network meta-analysis of randomized controlled trials
.
Topics: Bayes Theorem; Drug Therapy, Combination; Gout; Humans; Network Meta-Analysis; Randomized Controlled Trials as Topic; Thioglycolates; Triazoles; Uric Acid; Xanthine Oxidase | 2019 |
Therapeutic Strategies for the Treatment of Chronic Hyperuricemia: An Evidence-Based Update.
Topics: Acetamides; Allopurinol; Benzbromarone; Chronic Disease; Evidence-Based Medicine; Febuxostat; Gout Suppressants; Humans; Hyperuricemia; Naphthalenes; Nitriles; Phenylacetates; Polyethylene Glycols; Probenecid; Propionates; Pyridines; Thioglycolates; Triazoles; Urate Oxidase; Uricosuric Agents; Xanthine Oxidase | 2021 |
Interventions for tophi in gout.
Topics: Allopurinol; Febuxostat; Gout; Gout Suppressants; Humans; Polyethylene Glycols; Randomized Controlled Trials as Topic; Thioglycolates; Triazoles; Urate Oxidase | 2021 |
16 trial(s) available for triazoles and lesinurad
| Article | Year |
|---|---|
Pharmacodynamic, pharmacokinetic and tolerability evaluation of concomitant administration of lesinurad and febuxostat in gout patients with hyperuricaemia.
Topics: Adult; Aged; Colchicine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Thiazoles; Thioglycolates; Triazoles; Uric Acid | 2014 |
Pharmacokinetics, pharmacodynamics, and safety of lesinurad, a selective uric acid reabsorption inhibitor, in healthy adult males.
Topics: Administration, Oral; Adolescent; Adult; Biological Availability; Capsules; Cross-Over Studies; Double-Blind Method; Gastrointestinal Absorption; Healthy Volunteers; Humans; Male; Organic Anion Transporters; Organic Cation Transport Proteins; Pharmaceutical Solutions; Renal Elimination; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents; Young Adult | 2015 |
Lesinurad in combination with allopurinol: results of a phase 2, randomised, double-blind study in patients with gout with an inadequate response to allopurinol.
Topics: Adult; Allopurinol; Double-Blind Method; Drug Therapy, Combination; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Thioglycolates; Treatment Outcome; Triazoles | 2016 |
Lesinurad Combined With Allopurinol: A Randomized, Double-Blind, Placebo-Controlled Study in Gout Patients With an Inadequate Response to Standard-of-Care Allopurinol (a US-Based Study).
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Double-Blind Method; Drug Combinations; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Thioglycolates; Triazoles; United States; Uricosuric Agents; Young Adult | 2017 |
Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney.
Topics: Cell Line; Gout; Humans; Kidney; Male; Organic Anion Transporters; Organic Cation Transport Proteins; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents | 2016 |
Lesinurad in combination with allopurinol: a randomised, double-blind, placebo-controlled study in patients with gout with inadequate response to standard of care (the multinational CLEAR 2 study).
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Cardiovascular Diseases; Creatinine; Double-Blind Method; Drug Therapy, Combination; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Renal Insufficiency; Retreatment; Symptom Flare Up; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents; Young Adult | 2017 |
Effects of renal function on pharmacokinetics and pharmacodynamics of lesinurad in adult volunteers.
Topics: Administration, Oral; Adult; Aged; Area Under Curve; Biological Availability; Biomarkers; Creatinine; Female; Glomerular Filtration Rate; Gout Suppressants; Humans; Kidney; Kidney Diseases; Male; Metabolic Clearance Rate; Middle Aged; Renal Elimination; Severity of Illness Index; Thioglycolates; Triazoles; Uric Acid | 2016 |
Lesinurad, a Selective Uric Acid Reabsorption Inhibitor, in Combination With Febuxostat in Patients With Tophaceous Gout: Findings of a Phase III Clinical Trial.
Topics: Creatinine; Double-Blind Method; Drug Therapy, Combination; Febuxostat; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Thioglycolates; Treatment Outcome; Triazoles; Uric Acid | 2017 |
Lesinurad monotherapy in gout patients intolerant to a xanthine oxidase inhibitor: a 6 month phase 3 clinical trial and extension study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Double-Blind Method; Drug Resistance; Enzyme Inhibitors; Female; Gout; Humans; Male; Middle Aged; Thioglycolates; Treatment Outcome; Triazoles; Uricosuric Agents; Xanthine Oxidase; Young Adult | 2017 |
Lesinurad for the treatment of hyperuricaemia in people with gout.
Topics: Animals; Gout; Gout Suppressants; Haplorhini; Humans; Hyperuricemia; Thioglycolates; Triazoles | 2017 |
The Effect of Lesinurad in Combination With Allopurinol on Serum Uric Acid Levels in Patients With Gout.
Topics: Adult; Allopurinol; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Thioglycolates; Triazoles; Uric Acid | 2018 |
Verinurad combined with febuxostat in Japanese adults with gout or asymptomatic hyperuricaemia: a phase 2a, open-label study.
Topics: Administration, Oral; Adult; Aged; Benzbromarone; Dose-Response Relationship, Drug; Drug Therapy, Combination; Febuxostat; Female; Follow-Up Studies; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Organic Anion Transporters; Organic Cation Transport Proteins; Thioglycolates; Time Factors; Treatment Outcome; Triazoles; Uric Acid; Uricosuric Agents; Young Adult | 2018 |
Metabolism and disposition of lesinurad, a uric acid reabsorption inhibitor, in humans.
Topics: Adult; Biological Availability; Cytochrome P-450 CYP2C9; Humans; Infusions, Intravenous; Male; Renal Elimination; Thioglycolates; Triazoles; Uric Acid | 2019 |
Characterization of Stereoselective Metabolism, Inhibitory Effect on Uric Acid Uptake Transporters, and Pharmacokinetics of Lesinurad Atropisomers.
Topics: Administration, Oral; Adult; Gout; Healthy Volunteers; HEK293 Cells; Humans; Kidney; Male; Microsomes, Liver; Middle Aged; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Renal Reabsorption; Stereoisomerism; Structure-Activity Relationship; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents; Young Adult | 2019 |
Efficacy and safety during extended treatment of lesinurad in combination with febuxostat in patients with tophaceous gout: CRYSTAL extension study.
Topics: Adult; Drug Therapy, Combination; Febuxostat; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Thioglycolates; Treatment Outcome; Triazoles; Uricosuric Agents | 2019 |
Lesinurad: Evaluation of Pharmacokinetic and Pharmacodynamic Interactions With Warfarin in Healthy Volunteers.
Topics: Adult; Anticoagulants; Blood Coagulation; Cytochrome P-450 CYP2C9; Drug Interactions; Gout Suppressants; Healthy Volunteers; Humans; Male; Middle Aged; Prothrombin Time; Thioglycolates; Triazoles; Vitamin K Epoxide Reductases; Warfarin; Young Adult | 2019 |
38 other study(ies) available for triazoles and lesinurad
| Article | Year |
|---|---|
Treat to target in gout by combining two modes of action.
Topics: Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Thiazoles; Thioglycolates; Triazoles | 2014 |
In Vitro and In Vivo Interaction Studies Between Lesinurad, a Selective Urate Reabsorption Inhibitor, and Major Liver or Kidney Transporters.
Topics: Adolescent; Adult; Aged; Atorvastatin; Carrier Proteins; Cell Line; Diuretics; Drug Interactions; Furosemide; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Kidney; Liver; Liver-Specific Organic Anion Transporter 1; Male; Metformin; Middle Aged; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents; Young Adult | 2016 |
European drug agency launches website giving open access to trial data.
Topics: Access to Information; Antineoplastic Agents; Clinical Trials as Topic; Drug Industry; Europe; Gout; Gout Suppressants; Humans; Internet; Multiple Myeloma; Oligopeptides; Thioglycolates; Triazoles | 2016 |
Supratherapeutic dose evaluation and effect of lesinurad on cardiac repolarization: a thorough QT/QTc study.
Topics: Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Europe; Female; Heart Rate; Humans; Male; Statistics as Topic; Thioglycolates; Triazoles; Uric Acid; Xanthine Oxidase | 2016 |
Reply.
Topics: Allopurinol; Double-Blind Method; Gout; Humans; Thioglycolates; Triazoles | 2017 |
Lesinurad in Combination With Allopurinol: Risk Without Reward? Comment on the Article by Saag et al.
Topics: Allopurinol; Double-Blind Method; Gout; Humans; Reward; Thioglycolates; Triazoles | 2017 |
Lesinurad combination therapy with allopurinol in gout: do CLEAR studies make the treatment of gout clearer?
Topics: Allopurinol; Double-Blind Method; Gout; Humans; Standard of Care; Thioglycolates; Triazoles | 2017 |
Evaluation of Pharmacokinetic Interactions Between Lesinurad, a New Selective Urate Reabsorption Inhibitor, and CYP Enzyme Substrates Sildenafil, Amlodipine, Tolbutamide, and Repaglinide.
Topics: Adult; Amlodipine; Area Under Curve; Carbamates; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Gene Expression Regulation; Healthy Volunteers; Humans; In Vitro Techniques; Male; Middle Aged; Piperidines; Sildenafil Citrate; Thioglycolates; Tolbutamide; Triazoles; Young Adult | 2017 |
Evaluation of Pharmacokinetic Interactions Between Lesinurad, a New Selective Urate Reabsorption Inhibitor, and Commonly Used Drugs for Gout Treatment.
Topics: Adult; Aged; Aged, 80 and over; Colchicine; Drug Administration Schedule; Drug Interactions; Female; Gout Suppressants; Humans; Hyperuricemia; Indomethacin; Male; Middle Aged; Naproxen; Thioglycolates; Treatment Outcome; Triazoles; Uricosuric Agents; Young Adult | 2017 |
2017 New Drug Update.
Topics: Anti-Inflammatory Agents; Antipsychotic Agents; Drugs, Investigational; Dry Eye Syndromes; Gout Suppressants; Humans; Hypoglycemic Agents; Insulin, Long-Acting; Peptides; Phenylalanine; Piperidines; Sulfones; Thioglycolates; Triazoles; Urea | 2017 |
Impact of non-adherence on the safety and efficacy of uric acid-lowering therapies in the treatment of gout.
Topics: Computer Simulation; Drug Therapy, Combination; Febuxostat; Gout; Gout Suppressants; Humans; Male; Medication Adherence; Models, Biological; Risk Assessment; Thioglycolates; Treatment Outcome; Triazoles; Uric Acid; Xanthine Oxidase | 2018 |
Response to: 'A response to Singh. "Lesinurad combination therapy with allopurinol in gout: do CLEAR studies make the treatment of gout clearer?"' by Valiyil and Schechter.
Topics: Allopurinol; Double-Blind Method; Gout; Humans; Standard of Care; Thioglycolates; Triazoles | 2018 |
Lesinurad combination therapy with allopurinol in gout: do CLEAR studies make the treatment of gout clearer?
Topics: Allopurinol; Double-Blind Method; Gout; Humans; Standard of Care; Thioglycolates; Triazoles | 2018 |
Identification and characterization of a potent and selective inhibitor of human urate transporter 1.
Topics: Animals; Blood Urea Nitrogen; Cell Line; Cell Survival; Creatinine; Dogs; Humans; Hyperuricemia; Molecular Structure; Organic Anion Transporters; Organic Cation Transport Proteins; Rats; Thioglycolates; Triazoles | 2017 |
Lesinurad/Allopurinol (Duzallo) for Gout-Associated Hyperuricemia.
Topics: Allopurinol; Drug Combinations; Drug Interactions; Gout; Gout Suppressants; Humans; Hyperuricemia; Organic Anion Transporters; Organic Cation Transport Proteins; Thioglycolates; Triazoles; Xanthine Oxidase | 2018 |
Systematic Structure-Activity Relationship (SAR) Exploration of Diarylmethane Backbone and Discovery of A Highly Potent Novel Uric Acid Transporter 1 (URAT1) Inhibitor.
Topics: Benzbromarone; Biological Transport, Active; Carbon Radioisotopes; Drug Design; Gene Expression; HEK293 Cells; Humans; Methane; Organic Anion Transporters; Organic Cation Transport Proteins; Structure-Activity Relationship; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents | 2018 |
Validated Stability Indicating High Performance Liquid Chromatographic Determination of Lesinurad.
Topics: Acetonitriles; Chromatography, High Pressure Liquid; Drug Stability; Limit of Detection; Linear Models; Reproducibility of Results; Thioglycolates; Triazoles | 2018 |
Individualized treatment strategies for hyperuricemia informed by a semi-mechanistic exposure-response model of uric acid dynamics.
Topics: Allopurinol; Clinical Trials as Topic; Febuxostat; Humans; Hyperuricemia; Models, Theoretical; Precision Medicine; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents | 2018 |
Chronic Disease Approaches Needed to Curb Gout's Growing Burden.
Topics: Allopurinol; Chronic Disease; Diet; Drug Combinations; Febuxostat; Gout; Gout Suppressants; Healthy Lifestyle; Humans; Patient Education as Topic; Practice Guidelines as Topic; Purines; Thioglycolates; Triazoles; Uric Acid | 2018 |
Cost-Effectiveness Analysis of Lesinurad/Allopurinol Versus Febuxostat for the Management of Gout/Hyperuricemia in Italy.
Topics: Allopurinol; Cost-Benefit Analysis; Drug Costs; Drug Therapy, Combination; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Italy; Male; Markov Chains; Middle Aged; Models, Economic; Monte Carlo Method; Quality-Adjusted Life Years; Thioglycolates; Triazoles | 2018 |
Budget impact of adding lesinurad for second-line treatment of gout: a US health plan perspective.
Topics: Allopurinol; Budgets; Gout; Gout Suppressants; Humans; Markov Chains; Models, Econometric; Thioglycolates; Triazoles; United States | 2018 |
Zurampic Protects Pancreatic β-Cells from High Uric Acid Induced-Damage by Inhibiting URAT1 and Inactivating the ROS/AMPK/ERK Pathways.
Topics: AMP-Activated Protein Kinases; Animals; Anion Transport Proteins; Extracellular Signal-Regulated MAP Kinases; Insulin-Secreting Cells; MAP Kinase Signaling System; Rats; Reactive Oxygen Species; Thioglycolates; Triazoles; Uric Acid | 2018 |
Multiwavelength UV-metric and pH-metric determination of the multiple dissociation constants of the lesinurad.
Topics: Chemistry, Pharmaceutical; Hydrogen-Ion Concentration; Potentiometry; Spectrophotometry, Ultraviolet; Thermodynamics; Thioglycolates; Triazoles; Uricosuric Agents | 2018 |
Integrated safety studies of the urate reabsorption inhibitor lesinurad in treatment of gout.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Clinical Trials, Phase III as Topic; Drug Therapy, Combination; Enzyme Inhibitors; Female; Gout; Gout Suppressants; Humans; Kidney Diseases; Male; Middle Aged; Randomized Controlled Trials as Topic; Thioglycolates; Treatment Outcome; Triazoles; Uric Acid; Xanthine Oxidase; Young Adult | 2019 |
Urate transporter inhibitor lesinurad is a selective peroxisome proliferator-activated receptor gamma modulator (sPPARγM) in vitro.
Topics: 3T3 Cells; Adipocytes; Adipogenesis; Animals; Cell Differentiation; Gout; HEK293 Cells; Hep G2 Cells; Humans; Mice; Molecular Docking Simulation; PPAR gamma; Recombinant Proteins; Thioglycolates; Transfection; Triazoles; Uricosuric Agents | 2018 |
Impact of Non-Adherence and Flare Resolution on the Cost-Effectiveness of Treatments for Gout: Application of a Linked Pharmacometric/Pharmacoeconomic Model.
Topics: Allopurinol; Cohort Studies; Cost-Benefit Analysis; Drug Therapy, Combination; Economics, Pharmaceutical; Febuxostat; Gout; Gout Suppressants; Health Care Costs; Humans; Medication Adherence; Models, Biological; Models, Economic; Quality of Life; Quality-Adjusted Life Years; Thioglycolates; Treatment Outcome; Triazoles; United Kingdom; Uric Acid | 2018 |
Ultra-performance hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry for simultaneous determination of allopurinol, oxypurinol and lesinurad in rat plasma: Application to pharmacokinetic study in rats.
Topics: Allopurinol; Animals; Chromatography, Liquid; Hydrophobic and Hydrophilic Interactions; Oxypurinol; Rats; Reproducibility of Results; Tandem Mass Spectrometry; Thioglycolates; Tissue Distribution; Triazoles | 2019 |
Second-line treatment with lesinurad and allopurinol versus febuxostat for management of hyperuricemia: a cost-effectiveness analysis for Spanish patients.
Topics: Allopurinol; Cost-Benefit Analysis; Febuxostat; Gout Suppressants; Humans; Hyperuricemia; Markov Chains; Spain; Thioglycolates; Triazoles | 2019 |
The Effects of Special Patient Population Plasma on Pharmacokinetic Quantifications Using LC-MS/MS.
Topics: Allopurinol; Calibration; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Hepatic Insufficiency; Humans; Kidney; Liver; Oxypurinol; Reference Standards; Renal Insufficiency; Renal Reabsorption; Reproducibility of Results; Tandem Mass Spectrometry; Thioglycolates; Triazoles; Uricosuric Agents; Verapamil | 2019 |
Impact of Lesinurad and allopurinol on experimental Hyperuricemia in mice: biochemical, molecular and Immunohistochemical study.
Topics: Allopurinol; Animals; Blood Urea Nitrogen; Catalase; Drug Synergism; Glutathione Peroxidase; Gout Suppressants; Hyperuricemia; Interleukin-1beta; Kidney; Liver; Male; Mice; Thioglycolates; Triazoles; Tumor Necrosis Factor-alpha; Uric Acid; Xanthine Oxidase | 2020 |
Application of different spectrofluorimetric methods for determination of lesinurad and allopurinol in pharmaceutical preparation and human plasma.
Topics: Allopurinol; Calibration; Humans; Spectrometry, Fluorescence; Thioglycolates; Triazoles | 2021 |
Trends in Utilization of Urate-Lowering Therapies Following the US Food and Drug Administration's Boxed Warning on Febuxostat.
Topics: Allopurinol; Cardiovascular Diseases; Cause of Death; Drug Labeling; Febuxostat; Gout; Gout Suppressants; Humans; Mortality; Polyethylene Glycols; Practice Patterns, Physicians'; Probenecid; Risk Factors; Thioglycolates; Triazoles; United States; United States Food and Drug Administration; Urate Oxidase | 2021 |
Spectrophotometric determination of lesinurad and allopurinol in recently approved FDA pharmaceutical preparation.
Topics: Allopurinol; Spectrophotometry; Thioglycolates; Triazoles | 2021 |
Different chemometric assisted approaches for spectrophotometric quantitative analysis of lesinurad and allopurinol.
Topics: Allopurinol; Least-Squares Analysis; Spectrophotometry; Thioglycolates; Triazoles | 2021 |
A novel quality by design approach for development and validation of a green reversed-phase HPLC method with fluorescence detection for the simultaneous determination of lesinurad, febuxostat, and diflunisal: Application to human plasma.
Topics: Chromatography, High Pressure Liquid; Diflunisal; Equipment Design; Febuxostat; Fluorescence; Humans; Software; Tablets; Thioglycolates; Triazoles | 2021 |
Hepatic and Renal Impacts of Lesinurad on Experimental Hyperuricemia: Biochemical, Molecular and Pathological Investigations.
Topics: Animals; Humans; Hyperuricemia; Kidney; Liver; Male; Mice; Thioglycolates; Triazoles; Uricosuric Agents | 2021 |
Spectrophotometric quantitative analysis of lesinurad using extractive acid dye reaction based on greener selective computational approach.
Topics: Acids; Bromphenol Blue; Coloring Agents; Spectrophotometry; Thioglycolates; Triazoles | 2022 |
Different spectrophotometric methods for simultaneous determination of lesinurad and allopurinol in the new FDA approved pharmaceutical preparation; additional greenness evaluation.
Topics: Allopurinol; Gout; Gout Suppressants; Humans; Triazoles | 2023 |