Enophthalmos

Recession of the eyeball into the orbit.

Synonyms(1)

Synonym
Enophthalmos

Research Excerpts

Overview

Excerpt	Reference
"Enophthalmos is usually a consequence of orbital trauma resulting in a blowout fracture of the orbital floor."	( Kawahara, T; Miyaguchi, M; Sakai, S, 1992)
"Relative enophthalmos is often cited as a causative factor in the development of involutional entropion."	( Hammer, BJ; Kersten, RC; Kulwin, DR, 1997)
"Enophthalmos is one manifestation that may require corrective treatment."	( Boyd, JH; Holds, J; Yaffee, K, 1998)
"Late surgery for enophthalmos is technically more difficult but is not associated with poorer functional or cosmetic results."	( Inkster, CF; Leatherbarrow, B; Madill, SA; Maloof, AJ; Ng, SG, 2001)
"Enophthalmos is defined as a backward, and usually downward, displacement of the globe into the bony orbit."	( Clauser, L; Galiè, M; Pagliaro, F; Tieghi, R, 2008)
"Late enophthalmos is a well-known consequence of large orbital floor fractures."	( Cestari, DM; Gopal, H; Montezuma, SR; Savar, A; Torun, N; Turalba, A, 2008)
"Enophthalmos is a complex and unpredictable condition to treat secondarily, and this is likely to remain a difficult challenge."	( Holmes, S, 2011)
"Enophthalmos is defined as backward, usually downward, displacement of the globe into the bony orbit."	( Kim, YB; Nam, SM; Park, ES; Shin, HS, 2011)
"Enophthalmos is corrected mostly through reducing the enlarged orbit volume by identifying intact bone edges and spanning the defect with an implant or autogenous graft."	( Kang, SJ; Kim, JW, 2012)
"The enophthalmos is a rare cause of consultation in medical practice."	( Balbo, NS; Lahoz Ibaceta, MJ; Smith, RJ, 2014)
"Enophthalmos is a challenging surgical problem to correct."	( Adenuga, P; Brown, M; Gargesha, M; Guyuron, B; Lee, M; Molavi, S; Varghai, D; Zwiebel, S, 2014)
"Enophthalmos is the posterior displacement of the ocular globe within the bony orbit."	( Daizo, H; Kishibe, M; Shimada, K; Yamashita, A; Yamashita, M, 2015)
"Enophthalmos is a severe complication of primary reconstruction of orbital floor fractures."	( Badiali, G; Marchetti, C; Pizzigallo, A; Tarsitano, A, 2016)
"Posttraumatic enophthalmos is a relatively common problem following orbitozygomatic fractures."	( Eun, SC; Hong, SH; Kim, TH; Park, IH, 2017)
"Enophthalmos is caused by an increase of orbital volume after blowout fracture and is one of the most critical complications of such fractures, but is often masked by swelling soon after injury."	( Inoue, Y; Okumoto, T; Onishi, S; Sugiura, K; Yamada, H, 2017)
"Enophthalmos is one of the most distressing complications of orbital fracture, and when faced with a blowout fracture, plastic surgeons often find it difficult to determine the need for surgical correction."	( Kim, SW; Mo, YW; Shin, HK, 2020)
"Enophthalmos is one of the most distressing complications of blowout orbital fractures."	( Lee, WJ; Mo, YW; Ryu, DH; Shin, HK, 2023)

Context

Excerpt	Reference
"Post-traumatic enophthalmos has a complex pathogenesis, resulting from injuries to the bony walls of the orbit or to the intraorbital contents."	( Aldegheri, A; Gola, R; Tsakoniatis, N; Waller, PY, 1992)
"Non-traumatic enophthalmos has a wide variety of clinical presentations and may be the first manifestation of a number of local or systemic conditions."	( Athanasiov, PA; Prabhakaran, VC; Selva, D, 2008)
"Enophthalmos has many causes, and serious post-traumatic cases indicate the need for operation."	( Nightingale, CL; Shakib, K, 2019)

Treatment

Excerpt	Reference
"Despite adequate treatment, enophthalmos due to intraconjunctival corticosteroid injection and enlargement of the bony orbit after trauma remains a frequent complication."	( Aygit, AC; Cakir, B; Omur-Okten, O; Yalcin, O, 2012)

Research

Studies (371)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	9 (2.43)	23.3326
1990's	72 (19.41)	12.5806
2000's	85 (22.91)	18.1394
2010's	147 (39.62)	28.8240
2020's	58 (15.63)	9.53

Drug	Relationship Strength	Studies	Trials
salicylic acid	low	1	0
lactic acid	medium	2	1
formaldehyde	low	2	0
nickel	low	1	0
acetazolamide	low	1	0
fluconazole	low	1	0
guaifenesin	low	1	0
haloperidol	low	1	0
2-propanol	low	2	0
letrozole	low	1	0
prednisolone	low	2	0
thyroxine	low	1	0
pilocarpine	low	1	0
chloramphenicol	low	1	0
sucrose	low	1	0
ethylene oxide	low	1	0
methylmethacrylate	low	1	0
caprolactam	low	1	0
fluorometholone	low	1	0
durapatite	medium	9	1
titanium	medium	53	2
gold	low	1	0
phosphoric acid, trisodium salt	low	1	0
tricalcium phosphate	low	2	0
calcium sulfate	low	1	0
propiconazole	medium	315	9
itraconazole	low	1	0
topotecan	low	1	0
triazoles	low	1	0
htr composite	low	1	0
melphalan	low	1	0
travoprost	low	1	0
phenylephrine hydrochloride	low	8	0
bimatoprost	low	3	0
cloprostenol	low	1	0
latanoprost	low	1	0
aluminum oxide	low	1	0
cyclosporine	low	1	0
eye	medium	16	1

Protein Targets (604)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
RAR-related orphan receptor gamma	11	0	0	11
GLI family zinc finger 3	13	0	0	13
AR protein	13	0	0	13
aldehyde dehydrogenase 1 family, member A1	6	0	0	6
retinoic acid nuclear receptor alpha variant 1	13	0	0	13
retinoid X nuclear receptor alpha	8	0	0	8
estrogen nuclear receptor alpha	16	0	0	16
peroxisome proliferator-activated receptor delta	5	0	0	5
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	8	0	0	8
activating transcription factor 6	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	7	0	0	7
Histone H2A.x	4	0	0	4
thyroid hormone receptor beta isoform a	4	0	0	4
heat shock protein beta-1	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	10	0	0	10
lamin isoform A-delta10	5	0	0	5
Voltage-dependent calcium channel gamma-2 subunit	6	0	0	6
Glutamate receptor 2	6	0	0	6
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	3	0	0	3
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
thioredoxin reductase	7	0	0	7
GALC protein	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	10	0	0	10
cytochrome P450 family 3 subfamily A polypeptide 4	10	0	0	10
glucocorticoid receptor [Homo sapiens]	8	0	0	8
estrogen-related nuclear receptor alpha	13	0	0	13
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
arylsulfatase A	3	0	0	3
Carbonic anhydrase	0	1	0	1
euchromatic histone-lysine N-methyltransferase 2	7	0	0	7
Bloom syndrome protein isoform 1	2	0	0	2
geminin	8	0	0	8
peripheral myelin protein 22	5	0	0	5
survival motor neuron protein isoform d	3	0	0	3
muscleblind-like protein 1 isoform 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	5	1	0	6
ATP-binding cassette sub-family C member 3	0	9	0	9
Multidrug resistance-associated protein 4	0	9	0	9
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	2	0	2
Carbonic anhydrase 12	0	3	1	6
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	13	0	13
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	2	0	2
Carbonic anhydrase 1	0	5	1	10
Carbonic anhydrase 2	0	7	2	12
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	1	0	1
Carbonic anhydrase 3	0	3	1	6
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	6	0	7
Steryl-sulfatase	0	2	0	2
5-hydroxytryptamine receptor 2C	0	3	0	3
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2D6	0	1	0	1
Cytochrome P450 2A6	0	2	1	3
Cytochrome P450 2C9	0	4	0	4
5-hydroxytryptamine receptor 2A	0	3	0	3
Androgen receptor	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-1	5	1	0	6
Translocator protein	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	5	1	0	6
Gamma-aminobutyric acid receptor subunit gamma-2	5	1	0	6
Gamma-aminobutyric acid receptor subunit alpha-5	5	1	0	6
Gamma-aminobutyric acid receptor subunit alpha-3	5	1	0	6
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	1	0	1
Carbonic anhydrase 4	0	4	1	6
Carbonic anhydrase 6	0	3	1	5
Gamma-aminobutyric acid receptor subunit gamma-1	5	1	0	6
Gamma-aminobutyric acid receptor subunit alpha-2	5	1	0	6
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	2	0	2
Serum paraoxonase/arylesterase 1	0	1	0	1
Dipeptidyl peptidase 4	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	5	1	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	5	1	0	6
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	5	1	0	6
Adenosine receptor A2a	0	1	0	1
5-hydroxytryptamine receptor 2B	0	3	0	3
Sodium-dependent serotonin transporter	0	2	0	2
Delta-type opioid receptor	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	4	1	7
Carbonic anhydrase	0	1	0	1
Kappa-type opioid receptor	0	2	0	2
Carbonic anhydrase 7	0	3	1	5
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	1	2	0	3
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	1	0	1
D(2) dopamine receptor	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	5	1	0	6
Gamma-aminobutyric acid receptor subunit beta-3	5	1	0	6
Gamma-aminobutyric acid receptor subunit beta-2	5	1	0	6
Cholinesterase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Carbonic anhydrase 9	0	5	2	9
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Delta carbonic anhydrase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Renin	0	1	0	1
Carbonic anhydrase	0	1	0	1
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	2	1	4
GABA theta subunit	5	1	0	6
Canalicular multispecific organic anion transporter 1	0	8	0	8
Carbonic anhydrase 4	0	2	0	2
Carbonic anhydrase 15	0	2	0	3
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	3	0	4
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	5	1	0	6
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	3	1	6
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	4	1	7
SMAD family member 2	3	0	0	3
SMAD family member 3	3	0	0	3
caspase 7, apoptosis-related cysteine protease	3	0	0	3
caspase-3	3	0	0	3
interleukin 8	1	0	0	1
TDP1 protein	8	0	0	8
EWS/FLI fusion protein	7	0	0	7
farnesoid X nuclear receptor	6	0	0	6
pregnane X nuclear receptor	11	0	0	11
G	7	0	0	7
cytochrome P450 2D6	5	0	0	5
peroxisome proliferator activated receptor gamma	5	0	0	5
vitamin D (1,25- dihydroxyvitamin D3) receptor	4	0	0	4
aryl hydrocarbon receptor	5	0	0	5
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
thyroid hormone receptor beta isoform 2	7	0	0	7
DNA polymerase iota isoform a (long)	3	0	0	3
streptokinase A precursor	0	0	1	1
lethal factor (plasmid)	2	0	0	2
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
Interferon beta	8	0	0	8
HLA class I histocompatibility antigen, B alpha chain	7	0	0	7
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Cellular tumor antigen p53	9	0	0	9
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Inositol hexakisphosphate kinase 1	7	0	0	7
Methionine--tRNA ligase, mitochondrial	0	0	1	1
cytochrome P450 2C9, partial	7	0	0	7
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Thromboxane A2 receptor	0	1	1	2
Prostaglandin E2 receptor EP1 subtype	0	1	1	2
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin F2-alpha receptor	0	2	1	3
Prostaglandin E2 receptor EP3 subtype	0	1	1	2
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostacyclin receptor	0	1	0	1
Prostaglandin D2 receptor	0	1	0	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
acetylcholinesterase	3	0	0	3
apical membrane antigen 1, AMA1	2	0	0	2
unnamed protein product	0	1	0	1
chromobox protein homolog 1	4	0	0	4
transcriptional regulator ERG isoform 3	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	2
cytochrome P450 3A4 isoform 1	5	0	0	5
bcl-2-like protein 11 isoform 1	0	0	1	1
Histone deacetylase 3	0	1	0	1
Rap guanine nucleotide exchange factor 3	3	0	0	3
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Heme oxygenase 1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	4
Lanosterol 14-alpha demethylase	0	1	1	2
Aromatase	0	3	0	3
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Cytochrome P450 11B2, mitochondrial	0	2	0	2
ATP-dependent translocase ABCB1	0	1	0	1
Heme oxygenase 2	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Histone deacetylase 4	0	1	0	1
Cytochrome P450 144	0	0	2	2
Steroid C26-monooxygenase	0	0	2	2
Steroid C26-monooxygenase	0	0	2	2
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
TAR DNA-binding protein 43	5	0	0	5
Histone deacetylase 1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	1	2
Sterol 14-alpha demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	1	1	2
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
14-alpha sterol demethylase	0	0	1	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
heat shock protein 90, putative	0	0	0	2
likely tRNA 2'-phosphotransferase	0	1	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
progesterone receptor	6	0	0	6
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
lysosomal alpha-glucosidase preproprotein	2	0	0	2
huntingtin isoform 2	1	0	0	1
flap endonuclease 1	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
nuclear receptor ROR-gamma isoform 1	4	0	0	4
DNA polymerase kappa isoform 1	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Glucocorticoid receptor	0	6	2	13
Glycine receptor subunit alpha-1	0	6	0	6
Neuronal acetylcholine receptor subunit alpha-4	2	0	0	2
Neuronal acetylcholine receptor subunit beta-2	2	0	0	2
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	2	0	0	2
glp-1 receptor, partial	4	0	0	4
15-lipoxygenase, partial	2	0	0	2
ATAD5 protein, partial	1	0	0	1
Fumarate hydratase	4	0	0	4
NFKB1 protein, partial	1	0	0	1
Thrombopoietin	1	0	0	1
thyroid stimulating hormone receptor	2	0	0	2
regulator of G-protein signaling 4	2	0	0	2
nonstructural protein 1	2	0	0	2
polyprotein	4	0	0	4
glucocerebrosidase	2	0	0	2
Adenylate cyclase type 1	0	1	0	1
thyroid stimulating hormone receptor	3	0	0	3
cytochrome P450 2D6 isoform 1	1	0	0	1
peripheral myelin protein 22 isoform 1	1	0	0	1
cytochrome P450 2C9 precursor	2	0	0	2
D(1A) dopamine receptor	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
transient receptor potential cation channel subfamily V member 1	1	0	0	1
muscarinic acetylcholine receptor M1	1	0	0	1
Cocaine esterase	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	1	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Potassium channel subfamily K member 2	0	1	0	1
Albumin	0	0	1	1
Major prion protein	0	0	1	1
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	1	3
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M1	0	4	0	5
Muscarinic acetylcholine receptor M3	0	4	0	5
Muscarinic acetylcholine receptor M4	0	4	0	5
5-hydroxytryptamine receptor 1A	0	2	0	2
Muscarinic acetylcholine receptor M5	0	4	0	5
Muscarinic acetylcholine receptor M5	0	3	0	3
Alpha-2A adrenergic receptor	0	2	0	2
Beta-2 adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M2	0	4	0	5
Muscarinic acetylcholine receptor M1	0	3	2	5
Angiotensin-converting enzyme	0	1	0	1
Integrin alpha-4	0	1	0	1
D(2) dopamine receptor	0	2	1	5
Alpha-1B adrenergic receptor	0	2	0	2
Carbonyl reductase [NADPH] 1	0	0	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	2
Alpha-2B adrenergic receptor	0	2	0	2
Beta-1 adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	2	0	2
D	0	2	0	2
D(3) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
Alpha-2B adrenergic receptor	0	1	0	1
D(2) dopamine receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	1	0	1
D(1A) dopamine receptor	0	2	0	3
D(4) dopamine receptor	0	2	1	5
D(1B) dopamine receptor	0	2	0	3
Adenylate cyclase type 3	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Sodium-dependent noradrenaline transporter	0	2	0	2
Sodium-dependent dopamine transporter	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
D(1B) dopamine receptor	0	2	0	2
Beta-3 adrenergic receptor	0	1	0	1
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
5-hydroxytryptamine receptor 1B	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
D(4) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 1F	0	1	0	1
Histamine H1 receptor	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
C-8 sterol isomerase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Histamine H1 receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	1	0	1
Mu-type opioid receptor	0	2	1	3
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
D(3) dopamine receptor	0	2	1	5
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Adenylate cyclase type 8	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
Histamine H2 receptor	3	0	0	4
5-hydroxytryptamine receptor 2A	0	1	0	1
5-hydroxytryptamine receptor 6	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Cytochrome P450 2J2	0	2	0	2
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Spike glycoprotein	5	0	0	5
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Adenylate cyclase type 6	0	1	0	1
Adenylate cyclase type 5	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
5-hydroxytryptamine receptor 4	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Zinc finger protein 664	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Transporter	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Protease	0	2	0	2
Adenylyl cyclase 7	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
D	0	1	0	1
ATPase family AAA domain-containing protein 5	4	0	0	4
Sodium channel protein type 2 subunit alpha	0	1	0	1
Ataxin-2	4	0	0	4
Sigma non-opioid intracellular receptor 1	0	2	0	2
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
ATP-dependent phosphofructokinase	2	0	0	2
estrogen receptor 2 (ER beta)	5	0	0	5
cellular tumor antigen p53 isoform a	1	0	0	1
Integrin beta-3	1	0	0	1
Integrin alpha-IIb	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
Microtubule-associated protein tau	1	0	0	1
beta-2 adrenergic receptor	2	0	0	2
mitogen-activated protein kinase 1	1	0	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
USP1 protein, partial	3	0	0	3
cytochrome P450 2C19 precursor	2	0	0	2
runt-related transcription factor 1 isoform AML1b	1	0	0	1
vitamin D3 receptor isoform VDRA	3	0	0	3
core-binding factor subunit beta isoform 2	1	0	0	1
Estrogen receptor	0	3	0	3
Amine oxidase [flavin-containing] A	0	1	0	1
phosphopantetheinyl transferase	2	0	0	2
GLS protein	2	0	0	2
thioredoxin glutathione reductase	2	0	0	2
Smad3	1	0	0	1
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
Nuclear receptor ROR-gamma	2	0	0	2
Large neutral amino acids transporter small subunit 1	0	1	0	1
IDH1	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Muscarinic acetylcholine receptor M1	0	0	1	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Cytochrome P450 2A13	0	1	1	2
luciferase	0	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
Fatty acid-binding protein, liver	0	1	0	1
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Prostaglandin G/H synthase 2	0	2	0	2
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
pregnane X receptor	2	0	0	2
Chain A, Ferritin light chain	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
Guanine nucleotide-binding protein G	1	0	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
histone acetyltransferase KAT2A isoform 1	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Polyphenol oxidase 2	0	1	0	2
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Bile salt export pump	0	1	0	1
Albumin	0	1	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Acetylcholinesterase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
serine/threonine-protein kinase PLK1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	2	2
UDP-glucuronosyltransferase 1A1	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Solute carrier organic anion transporter family member 1B1	0	0	0	1
NPYLR7B	0	0	1	1
tyrosine-protein kinase Yes	1	0	0	1
Solute carrier family 22 member 2	0	1	0	1
DNA topoisomerase 1	0	1	2	4
DNA topoisomerase 2-alpha	0	1	0	1
DNA topoisomerase 2-beta	0	1	0	1
DNA topoisomerase 1	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	1	1	2
Multidrug and toxin extrusion protein 2	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Endothelial PAS domain-containing protein 1	0	0	1	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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Enophthalmos

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (371)

Drugs Studied (45)

Protein Targets (604)