Page last updated: 2024-09-27

Adolescent Myoclonic Epilepsy

A disorder characterized by the onset of myoclonus in adolescence, a marked increase in the incidence of absence seizures (see EPILEPSY, ABSENCE), and generalized major motor seizures (see EPILEPSY, TONIC-CLONIC). The myoclonic episodes tend to occur shortly after awakening. Seizures tend to be aggravated by sleep deprivation and alcohol consumption. Hereditary and sporadic forms have been identified. (From Adams et al., Principles of Neurology, 6th ed, p323)

Synonyms(16)

Synonym
Janz Impulsive Petit Mal
Juvenile Myoclonic Epilepsy
Impulsive Petit Mal, Janz
Impulsive Petit Mal Epilepsy
Juvenile Myoclonic Epilepsy of Janz
JME (Juvenile Myoclonic Epilepsy)
Myoclonic Epilepsy, Adolescent
Janz Juvenile Myoclonic Epilepsy
Adolescent Myoclonic Epilepsy
Janz Syndrome
Epilepsy, Myoclonic, Juvenile
Epilepsy, Myoclonic Juvenile
Petit Mal, Impulsive
Petit Mal, Impulsive, Janz
Myoclonic Epilepsy, Juvenile, 1
Myoclonic Epilepsy, Juvenile

Research Excerpts

Overview

ExcerptReference
"Juvenile myoclonic epilepsy is a frequent form of idiopathic generalized epilepsy that is usually and easily controlled by valproate monotherapy."( Dravet, C; Gelisse, P; Genton, P; Thomas, P, 2000)
"Juvenile myoclonic epilepsy is one of the most common idiopathic generalized epilepsies, with most patients experiencing PGTCS."( Biton, V; Bourgeois, BF, 2005)
"Juvenile myoclonic epilepsy is a heterogeneous syndrome, both in genetic and clinical aspects."( Mohammad Ali, S; Motamedi, M; Rahmat, M, 2006)
"Juvenile myoclonic epilepsy is a clinically well-defined, age-related common idiopathic generalized epilepsy syndrome with substantial genetic basis to its etiology."( Anand, A; Kapoor, A; Kuruttukulam, G; Ratnapriya, R, 2007)
"Juvenile myoclonic epilepsy is a common idiopathic generalized epileptic syndrome that includes generalized myoclonic seizures and commonly generalized tonic-clonic and generalized absence seizures."( Abou-Khalil, B; Montouris, G, 2009)
"Juvenile myoclonic epilepsy is the most frequent idiopathic generalized epilepsy syndrome."( Barker, GJ; Duncan, JS; Janz, D; Koepp, MJ; Kumari, V; O'Muircheartaigh, J; Richardson, MP; Symms, MR; Thompson, P; Vollmar, C, 2011)
"Juvenile myoclonic epilepsy is the most common form of idiopathic generalized epilepsy with onset at puberty or late teenage years."( Adamolekun, B; Afra, P, 2012)
"Juvenile myoclonic epilepsy is often regarded as a benign epileptic syndrome, but in this setting, half of the individuals with JME have refractory epilepsy with only about a quarter of those seizure-free in the previous year."( Cação, G; Mannan, S; Parra, J; Sander, JW; Sisodiya, SM, 2018)

Treatment

ExcerptReference
"To determine the risk of aggravation of juvenile myoclonic epilepsy in patients treated with carbamazepine and phenytoin."( Dravet, C; Gelisse, P; Genton, P; Thomas, P, 2000)
"Fourteen patients with juvenile myoclonic epilepsy (JME) were treated with a single low dose of a sustained-release preparation of sodium valproate (VPA, 500 mg daily)."( Alexiou, D; Angelopoulos, P; Armentsoudis, P; Baloyannis, S; Delithanasis, I; Dimitrakoudi, E; Hamlatzis, P; Karlovassitou-Koniari, A, 2002)
"The recommended treatment for juvenile myoclonic epilepsy (JME) is valproate (VPA)."( Hardison, H; Khurana, DS; Kothare, SV; Legido, A; Melvin, JJ; Valencia, I, 2004)
"We have treated a patient with juvenile myoclonic epilepsy who had frequent and inconvenient morning myoclonus with 3,200 mg of piracetam daily."( Andermann, E; Andermann, F; Khani, YA, 2005)
"Drug treatment of juvenile myoclonic epilepsy (JME) is mainly based on clinical experience and prospective and retrospective studies, with little evidence from randomized clinical trials."( Auvin, S, 2008)
"About 80-90% of patients with juvenile myoclonic epilepsy respond to appropriate antiepileptic treatment and achieve seizure freedom, and about 15% of patients become intractable."( Adamolekun, B; Afra, P, 2012)
"A 15-year-old boy with juvenile myoclonic epilepsy developed acute pancreatitis after 2-month therapy with valproic acid."( Talvik, I; Talvik, T; Uibo, O; Veri, K, 2013)
"A 27-year-old woman was diagnosed with juvenile myoclonic epilepsy since the age of 13 and was on valproate therapy."( Acharya, M; Kumawat, BL; Parekh, J; Sharma, C, 2014)
"We aimed to investigate juvenile myoclonic epilepsy (JME) patients complaining of tremor unrelated to valproate (VPA) treatment and evaluate if there were differences between JME patients with and without tremor and essential tremor (ET) patients to exclude comorbidity."( Aydin-Özemir, Z; Baykan, B; Bebek, N; Bilgic, B; Gurses, C; Hanagasi, H; Matur, Z; Oge, AE; Tekturk, P, 2016)
"A 29-year-old man with juvenile myoclonic epilepsy and medically refractory GTCS on a combination of levetiracetam and topiramate was started on lacosamide adjunctive therapy with the plan to replace topiramate."( Ákos Szabó, C; Karkar, KM; Morgan, LC; Sonnenberg, S, 2019)

Research

Studies (181)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's2 (1.10)12.5806
2000's87 (48.07)18.1394
2010's73 (40.33)28.8240
2020's19 (10.50)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low90
choline0low30
chlorine0low10
salicylic acid0low10
creatine0low60
cytosine0low10
glycine0low10
inositol0low20
thymine0low10
n-methyl-3,4-methylenedioxyamphetamine0low10
phenytoin0low20
acetaminophen0low10
carbamazepine0low100
clobazam0low10
clonazepam0low10
valproic acid0medium867
ethosuximide0low10
hydroxyurea0low10
ketamine0low10
lamotrigine0medium232
apnea0low10
oxazepam0low10
phenobarbital0low10
piracetam0medium225
vorinostat0low10
vigabatrin0low10
zonisamide0medium71
aspartic acid0low60
glutamine0low20
testosterone propionate0low10
androstenedione0low10
isoxazoles0medium61
flurothyl0low10
methoxyhydroxyphenylglycol0low10
formestane0low10
glutamic acid0low20
adenosine diphosphate ribose0low10
oxcarbazepine0low50
paroxetine0low10
fomesafen0low40
n-acetylaspartic acid0low60
triazoles0low10
fluorodeoxyglucose f180low20
dipropylacetamide0low10
homocysteine0low10
rufinamide0low10
lacosamide0low30
carnosine0low10
D-fructopyranose0medium124
levetiracetam0medium306
topiramate0medium154
stiripentol0low10
phosphocreatine0low10
ucb 347140low20
perampanel0low20
g(m1) ganglioside0low10
n-((1-allyl-2-pyrrolidinyl)methyl)-5-(3-fluoropropyl)-2,3-dimethoxybenzamide0low10
homocarnosine0low10
nad0low10
exudates0low10
folic acid0low10
eye0low10

Protein Targets (672)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
RAR-related orphan receptor gamma9009
ATAD5 protein, partial5005
GLS protein9009
Microtubule-associated protein tau4004
Smad34004
aldehyde dehydrogenase 1 family, member A18008
thyroid stimulating hormone receptor7007
nuclear receptor subfamily 1, group I, member 39009
progesterone receptor8008
EWS/FLI fusion protein6006
retinoic acid nuclear receptor alpha variant 1110011
retinoid X nuclear receptor alpha8008
estrogen-related nuclear receptor alpha160016
estrogen nuclear receptor alpha170017
peroxisome proliferator activated receptor gamma7007
aryl hydrocarbon receptor3003
chromobox protein homolog 19009
thyroid hormone receptor beta isoform 28008
peripheral myelin protein 225005
cytochrome P450 3A4 isoform 14004
Gamma-aminobutyric acid receptor subunit pi4408
ATP-binding cassette sub-family C member 3014014
Multidrug resistance-associated protein 4014015
Solute carrier family 22 member 60202
Carbonic anhydrase 120609
UDP-glucuronosyltransferase 1A90002
Bile salt export pump0404
Voltage-dependent calcium channel gamma-2 subunit3003
Bile salt export pump019019
Cytochrome P450 2B10001
Cytochrome P450 1A10001
Carbonic anhydrase 1010017
Carbonic anhydrase 2011221
Myoglobin0101
Cytochrome P450 1A10012
Cytochrome P450 1A20001
Prostaglandin G/H synthase 10101
Carbonic anhydrase 30607
Cytochrome P450 3A40405
Cytochrome P450 2D60607
Cytochrome P450 2C9 0505
Polyunsaturated fatty acid lipoxygenase ALOX150101
Gamma-aminobutyric acid receptor subunit beta-14408
Sulfotransferase 1A1 0001
Gamma-aminobutyric acid receptor subunit delta4408
Gamma-aminobutyric acid receptor subunit gamma-24419
UDP-glucuronosyltransferase 1-60002
Glutamate receptor 23216
Gamma-aminobutyric acid receptor subunit alpha-54408
Gamma-aminobutyric acid receptor subunit alpha-34408
Arachidonate 5-lipoxygenase-activating protein0303
UDP-glucuronosyltransferase 1A1 0001
Carbonic anhydrase 408012
Prostaglandin G/H synthase 10202
Carbonic anhydrase 60609
Gamma-aminobutyric acid receptor subunit gamma-14408
Gamma-aminobutyric acid receptor subunit alpha-24408
Gamma-aminobutyric acid receptor subunit alpha-44408
Gamma-aminobutyric acid receptor subunit gamma-34408
Gamma-aminobutyric acid receptor subunit alpha-64408
Carbonic anhydrase 5A, mitochondrial08213
Prostaglandin G/H synthase 20203
Carbonic anhydrase 70609
Nuclear receptor ROR-gamma3003
Cytochrome P450 2J20202
Gamma-aminobutyric acid receptor subunit alpha-14419
Gamma-aminobutyric acid receptor subunit beta-34408
Gamma-aminobutyric acid receptor subunit beta-24419
Carbonic anhydrase 907011
GABA theta subunit4408
Canalicular multispecific organic anion transporter 1014014
Carbonic anhydrase 150607
Carbonic anhydrase 130305
Gamma-aminobutyric acid receptor subunit epsilon4408
Carbonic anhydrase 140609
Carbonic anhydrase 5B, mitochondrial0609
toxin B0001
TDP1 protein150015
Transient receptor potential cation channel subfamily M member 20011
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
interleukin 81001
acetylcholinesterase4004
SMAD family member 22002
SMAD family member 32002
GLI family zinc finger 3100010
AR protein150015
estrogen receptor 2 (ER beta)7007
regulator of G-protein signaling 44004
cytochrome P450 family 3 subfamily A polypeptide 47007
nonstructural protein 12002
glucocorticoid receptor [Homo sapiens]7007
farnesoid X nuclear receptor6006
pregnane X nuclear receptor130013
peroxisome proliferator-activated receptor delta3003
vitamin D (1,25- dihydroxyvitamin D3) receptor6006
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a9009
Histone H2A.x3003
Caspase-72002
Bloom syndrome protein isoform 1110011
peripheral myelin protein 22 isoform 15005
potassium voltage-gated channel subfamily H member 2 isoform d3003
caspase-32002
importin subunit beta-1 isoform 11001
mitogen-activated protein kinase 13003
nuclear factor NF-kappa-B p105 subunit isoform 11001
snurportin-11001
nuclear factor erythroid 2-related factor 2 isoform 18008
GTP-binding nuclear protein Ran isoform 11001
DNA polymerase iota isoform a (long)3003
nuclear receptor ROR-gamma isoform 14004
geminin170017
survival motor neuron protein isoform d3003
muscleblind-like protein 1 isoform 11001
lamin isoform A-delta10120012
neuropeptide S receptor isoform A4004
Sex hormone-binding globulin0011
Beta-glucuronidase0101
Cholinesterase0101
Corticosteroid-binding globulin0101
Aromatase0408
Androgen receptor0303
Gastrin/cholecystokinin type B receptor0102
Testosterone 17-beta-dehydrogenase 30101
Alpha-synuclein1102
TAR DNA-binding protein 436006
thioredoxin reductase130013
arylsulfatase A100010
euchromatic histone-lysine N-methyltransferase 2160016
D(1A) dopamine receptor6006
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE8008
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Chain A, Ferritin light chain3003
phosphopantetheinyl transferase5005
cytochrome P450 2C19 precursor3003
lethal factor (plasmid)2002
Metabotropic glutamate receptor 60124
Excitatory amino acid transporter 40202
Glutamate transporter homolog0011
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase0101
5-hydroxytryptamine receptor 1D0002
Glutamate receptor ionotropic, NMDA 1 07210
Excitatory amino acid transporter 10304
Excitatory amino acid transporter 20304
Excitatory amino acid transporter 30304
Glutamate receptor ionotropic, NMDA 2A 07210
Glutamate receptor ionotropic, NMDA 2B09212
Glutamate receptor ionotropic, NMDA 2C07210
Metabotropic glutamate receptor 10124
Metabotropic glutamate receptor 20124
Carbonic anhydrase-like protein, putative0004
Glutamate receptor ionotropic, NMDA 2D07210
Glutamate receptor ionotropic, NMDA 3B07210
Carbonic anhydrase 40204
Glutamate receptor ionotropic, NMDA 3A07210
Chain A, Beta-lactamase2002
USP1 protein, partial5005
IDH12002
thyroid hormone receptor beta isoform a5005
nuclear factor erythroid 2-related factor 2 isoform 24004
Vpr1001
Albumin0011
Major prion protein0011
Cellular tumor antigen p539009
Sodium channel protein type 1 subunit alpha0202
Sodium channel protein type 2 subunit alpha0404
Sodium channel protein type 3 subunit alpha0303
UDP-glucuronosyltransferase 2B70103
Cytochrome P450 2B60011
Sodium channel protein type 4 subunit alpha0407
Potassium voltage-gated channel subfamily H member 20808
Sodium channel protein type 9 subunit alpha0505
Frizzled-80011
P2X purinoceptor 40303
cytochrome P450 2D6 isoform 12002
cytochrome P450 2C9 precursor3003
Histamine H2 receptor3104
Solute carrier family 15 member 10101
Solute carrier family 15 member 20101
Solute carrier family 15 member 20101
Carbonic anhydrase0203
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein0011
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Choline-binding protein0011
muscarinic acetylcholine receptor M14004
Solute carrier family 22 member 10102
Solute carrier family 22 member 20001
Solute carrier family 22 member 1 0102
Solute carrier family 22 member 20101
Neuronal acetylcholine receptor subunit alpha-30101
Neuronal acetylcholine receptor subunit alpha-40202
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit beta-20202
Neuronal acetylcholine receptor subunit beta-30101
Neuronal acetylcholine receptor subunit beta-40101
Neuronal acetylcholine receptor subunit alpha-50101
Acetylcholinesterase0202
Sodium- and chloride-dependent creatine transporter 10101
Choline O-acetyltransferase 0001
Neuronal acetylcholine receptor subunit alpha-60101
Neuronal acetylcholine receptor subunit alpha-90101
Neuronal acetylcholine receptor subunit alpha-70202
Solute carrier family 22 member 10102
High affinity choline transporter 10101
Neuronal acetylcholine receptor subunit alpha-100101
Solute carrier family 22 member 20102
ATP-dependent phosphofructokinase6006
nuclear receptor subfamily 1, group I, member 21001
Gamma-aminobutyric acid receptor subunit pi0505
Gamma-aminobutyric acid receptor subunit delta0505
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit alpha-10527
Gamma-aminobutyric acid receptor subunit beta-10516
Gamma-aminobutyric acid receptor subunit gamma-20527
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit beta-30516
Translocator protein0101
Translocator protein0202
Cholecystokinin receptor type A0101
Gamma-aminobutyric acid receptor subunit alpha-50516
Gamma-aminobutyric acid receptor subunit alpha-30516
Gamma-aminobutyric acid receptor subunit alpha-20516
Gamma-aminobutyric acid receptor subunit beta-20527
Gamma-aminobutyric acid receptor subunit alpha-40516
Gamma-aminobutyric acid receptor subunit epsilon0505
Gamma-aminobutyric acid receptor subunit alpha-60516
Gamma-aminobutyric acid receptor subunit gamma-10505
Gamma-aminobutyric acid receptor subunit gamma-30505
Gamma-aminobutyric acid receptor subunit theta0505
Sodium- and chloride-dependent creatine transporter 10101
Proton-coupled amino acid transporter 10404
Deoxycytidine kinase0001
Chain A, limonene-1,2-epoxide hydrolase0101
Chain A, Epoxide hydrolase0101
hypoxia-inducible factor 1 alpha subunit3003
Voltage-dependent T-type calcium channel subunit alpha-1I0101
Chain A, Dihydrofolate reductase0011
Chain A, Putative fructose-1,6-bisphosphate aldolase3003
Chain A, 2-oxoglutarate Oxygenase4004
acid sphingomyelinase1001
glp-1 receptor, partial4004
glucocerebrosidase1001
alpha-galactosidase1001
activating transcription factor 64004
lysosomal alpha-glucosidase preproprotein1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
DNA polymerase beta1001
Thymidylate synthase0202
Thymidylate synthase0101
Dihydrofolate reductase0213
Aldo-keto reductase family 1 member B10202
Folylpolyglutamate synthase, mitochondrial0001
Solute carrier organic anion transporter family member 1A30101
Folylpolyglutamate synthase, mitochondrial0001
Multidrug resistance associated protein0001
Luciferase3003
thyroid stimulating hormone receptor3003
v-jun sarcoma virus 17 oncogene homolog (avian)3003
tyrosine-protein kinase Yes1001
Gamma-aminobutyric acid 0112
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0023
bromodomain adjacent to zinc finger domain 2B1001
transcriptional regulator ERG isoform 33003
histone-lysine N-methyltransferase 2A isoform 2 precursor3003
histone acetyltransferase KAT2A isoform 14004
Histone deacetylase 30519
Gamma-aminobutyric acid type B receptor subunit 20112
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-60112
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit delta0112
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20112
Gamma-aminobutyric acid receptor subunit alpha-30112
Gamma-aminobutyric acid receptor subunit gamma-30112
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit beta-10112
Histone deacetylase 40519
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-30112
4-aminobutyrate aminotransferase, mitochondrial0102
4-aminobutyrate aminotransferase, mitochondrial0102
Histone deacetylase 105210
Sterol O-acyltransferase 10011
Gamma-aminobutyric acid receptor subunit alpha-50112
Gamma-aminobutyric acid receptor subunit pi0112
Histone deacetylase 705210
Histone deacetylase 205210
Polyamine deacetylase HDAC100519
Histone deacetylase 11 0519
Histone deacetylase 805210
Gamma-aminobutyric acid receptor subunit alpha-40112
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0112
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10112
Histone deacetylase 605210
Gamma-aminobutyric acid type B receptor subunit 10112
Histone deacetylase 90519
Histone deacetylase 50519
Gamma-aminobutyric acid type B receptor subunit 10101
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
beta-2 adrenergic receptor1001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
Metabotropic glutamate receptor 80202
Glutamate receptor ionotropic, NMDA 2D0202
Glutamate receptor ionotropic, NMDA 3B0202
Glutathione reductase, mitochondrial0202
Bifunctional aspartokinase/homoserine dehydrogenase 10101
Prothrombin0011
Integrin beta-30011
Integrin alpha-IIb0011
ATP-citrate synthase 0101
Glutamate receptor 10213
Glutamate receptor 30213
Glutamate receptor 40213
Glutamate receptor ionotropic, kainate 10213
Metabotropic glutamate receptor 10112
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50011
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, kainate 10112
Metabotropic glutamate receptor 50113
Glutamate receptor ionotropic, kainate 20213
Glutamate receptor 10314
Glutamate receptor 20213
Glutamate receptor 30112
Glutamate receptor ionotropic, kainate 30202
Metabotropic glutamate receptor 80011
Glutamate receptor 40213
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Fatty-acid amide hydrolase 10101
Glutamate receptor ionotropic, kainate 40202
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, NMDA 10303
Glutamate receptor ionotropic, NMDA 2A0303
Glutamate receptor ionotropic, kainate 20112
Glutamate receptor ionotropic, kainate 30101
Glutamate receptor ionotropic, NMDA 2B0303
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate receptor ionotropic, NMDA 2C0202
Glutamate receptor ionotropic, kainate 50101
Glutamate receptor ionotropic, kainate 50202
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Glutamate receptor ionotropic, NMDA 3A0202
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Chain A, Glutamine Binding Protein0011
15-lipoxygenase, partial1001
flap endonuclease 13003
Neutral amino acid transporter A0202
Asc-type amino acid transporter 10101
Neutral amino acid transporter B(0)0202
Amino acid transporter0202
Glycine receptor subunit alpha-10011
Sodium- and chloride-dependent glycine transporter 10101
Large neutral amino acids transporter small subunit 10202
Serine racemase0101
Olfactory receptor 51E20011
Sodium- and chloride-dependent glycine transporter 20101
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10101
Fumarate hydratase1001
NFKB1 protein, partial1001
polyprotein1001
vitamin D3 receptor isoform VDRA3003
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
Stromelysin-10022
Urease subunit alpha0101
Ribonucleoside-diphosphate reductase large subunit0101
Urease subunit beta0101
Inositol monophosphatase 12002
Chain B, Pulmonary surfactant-associated protein D0101
Chain A, Pulmonary surfactant-associated protein D0101
parathyroid hormone/parathyroid hormone-related peptide receptor precursor3003
Amyloid-beta precursor protein0202
Sodium/myo-inositol cotransporter 20101
Acetylcholinesterase0202
Rap guanine nucleotide exchange factor 31001
Cholinesterase0202
Potassium voltage-gated channel subfamily E member 10202
Potassium voltage-gated channel subfamily KQT member 10202
Voltage-dependent L-type calcium channel subunit alpha-1C0404
Sodium channel protein type 5 subunit alpha0303
Sodium channel protein type 10 subunit alpha0101
Carbonic anhydrase 130404
GALC protein2002
cytochrome P450 2D65005
Sodium channel protein type 2 subunit alpha0303
Sodium channel protein type 3 subunit alpha0303
Sigma non-opioid intracellular receptor 10101
Sodium channel protein type 10 subunit alpha0101
chaperonin-containing TCP-1 beta subunit homolog2002
Synaptic vesicle glycoprotein 2A0303
D(2) dopamine receptor0202
D(4) dopamine receptor0101
D(3) dopamine receptor0101
67.9K protein1001
DNA polymerase kappa isoform 13003
Solute carrier family 22 member 200202
Solute carrier family 22 member 60202
Rap guanine nucleotide exchange factor 42002
Aldo-keto reductase family 1 member B10303
Sodium-dependent noradrenaline transporter 0426
Sodium-dependent dopamine transporter0314
Sodium-dependent serotonin transporter0426
Sodium-dependent serotonin transporter0325
Sodium-dependent dopamine transporter 0426
Trace amine-associated receptor 10011
Chain B, Exotoxin A0011
Chain B, Exotoxin A0011
Chain B, Exotoxin A0011
Albumin0213
polyadenylate-binding protein 10101
bcl-2-related protein A10101
Spike glycoprotein5005
G5005
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
NPC intracellular cholesterol transporter 1 precursor1001
atrial natriuretic peptide receptor 2 precursor1001
ras-related protein Rab-9A1001
serine/threonine-protein kinase mTOR isoform 11001
M-phase phosphoprotein 82002
Sodium-dependent noradrenaline transporter0101
Voltage-dependent L-type calcium channel subunit alpha-1F0202
Interferon beta7007
HLA class I histocompatibility antigen, B alpha chain 5005
Myeloperoxidase0101
Aldo-keto reductase family 1 member B10303
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40202
ATP-dependent translocase ABCB10101
5-hydroxytryptamine receptor 1A0011
Muscarinic acetylcholine receptor M50202
Quinolone resistance protein NorA0101
Muscarinic acetylcholine receptor M10202
Angiotensin-converting enzyme0202
Alpha-2B adrenergic receptor0101
Muscarinic acetylcholine receptor M30202
Beta-adrenergic receptor kinase 10101
Potassium voltage-gated channel subfamily A member 30101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Beta-adrenergic receptor kinase 10112
Substance-P receptor0101
Rhodopsin kinase GRK10101
G protein-coupled receptor kinase 50101
G protein-coupled receptor kinase 50101
D(1A) dopamine receptor1001
P2X purinoceptor 40101
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Envelope glycoprotein0011
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Rhodopsin kinase GRK10101
Sodium-dependent serotonin transporter0101
Sodium-dependent dopamine transporter0101
Nuclear receptor subfamily 3 group C member 3 0202
Inositol hexakisphosphate kinase 15005
ATPase family AAA domain-containing protein 53003
Ataxin-23003
Sigma non-opioid intracellular receptor 10202
Beta-adrenergic receptor kinase 10001
Transporter0202
cytochrome P450 2C9, partial5005
Replicase polyprotein 1ab0101
Sodium channel protein type 1 subunit alpha0202
endonuclease IV2002
atrial natriuretic peptide receptor 1 precursor1001
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Dihydrofolate reductase 0101
5-hydroxytryptamine receptor 1A0202
Guanine nucleotide-binding protein G1001
Parkin1001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Polyphenol oxidase 20103
5'-AMP-activated protein kinase subunit beta-20001
Polymerase acidic protein0011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Cystathionine gamma-lyase0101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase0101
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 80101
Ubiquitin-like domain-containing CTD phosphatase 10101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
5'-AMP-activated protein kinase subunit beta-10001
Pyruvate kinase PKM0011
pregnane X receptor2002
caspase 7, apoptosis-related cysteine protease2002
caspase-32002
heat shock protein beta-11001
Steroid 17-alpha-hydroxylase/17,20 lyase0101
Androgen receptor0102
Androgen receptor0011
Neuropeptide FF receptor 20001
Thymidine phosphorylase0101
Chain A, Carbonic anhydrase 10101
Carbonic anhydrase 0002
Carbonic anhydrase 0202
Carbonic anhydrase 0202
Carbonic anhydrase 0202
Carbonic anhydrase0202
Carbonic anhydrase0202
Prolyl endopeptidase0202
Carbonic anhydrase-related protein 110001
Polyunsaturated fatty acid 5-lipoxygenase0203
Cytochrome P450 2C80202
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase 20101
Delta-type opioid receptor0202
Cytochrome P450 2C190202
Delta-type opioid receptor0202
Mu-type opioid receptor0202
Carbonic anhydrase0203
D(2) dopamine receptor0202
Carbonic anhydrase 0202
Mu-type opioid receptor0202
Beta-carbonic anhydrase 10202
Carbonic anhydrase 20202
Carbonic anhydrase, alpha family 0202
Carbonic anhydrase 0203
Carbonic anhydrase0102
Carbonic anhydrase0203
Carbonic anhydrase 0202
Delta carbonic anhydrase0202
Carbonic anhydrase 0203
Mu-type opioid receptor0112
Delta-type opioid receptor0202
Kappa-type opioid receptor0101
Chain A, CHORISMATE MUTASE0101
Chain A, TYROSYL-tRNA SYNTHETASE0011
Plasma kallikrein0001
Adenosine receptor A10001
Adenosine receptor A2a0001
SLC16A10 protein0001
Tubulin--tyrosine ligase0101
Monocarboxylate transporter 100001
Taste receptor type 2 member 140001
Cocaine esterase0101
Cytochrome P450 2A60101
Tissue factor0101
Aldo-keto reductase family 1 member A10101
Liver carboxylesterase 10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
Sigma non-opioid intracellular receptor 10202
NAD-dependent protein deacylase sirtuin-5, mitochondrial0202
4-aminobutyrate aminotransferase, mitochondrial0101
Chain A, Histone deacetylase-like amidohydrolase0101
Chain A, Histone deacetylase-like amidohydrolase0101
Histone deacetylase 80101
Nrf21001
PAX80001
PPM1D protein1001
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 70001
Histone deacetylase 0101
Lysine-specific demethylase 4E0101
Gli10101
nuclear receptor subfamily 0 group B member 10101
cystic fibrosis transmembrane conductance regulator0101
histone deacetylase 9 isoform 31001
steroidogenic factor 10101
protein Wnt-3a precursor0101
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
Histone deacetylase 10202
Transient receptor potential cation channel subfamily V member 10101
Lysine-specific histone demethylase 1A0101
Tyrosine-protein kinase JAK20101
Bromodomain-containing protein 40101
Nuclear receptor corepressor 10202
Nuclear receptor subfamily 1 group I member 20011
Tyrosine-protein kinase ABL10101
Epidermal growth factor receptor0101
Tubulin alpha-1A chain0101
Tubulin beta chain0101
3-hydroxy-3-methylglutaryl-coenzyme A reductase0101
Protein Tat0011
Heat shock protein HSP 90-alpha0101
Leukotriene A-4 hydrolase0101
Aminopeptidase N0101
Alpha-1B adrenergic receptor0101
Polyunsaturated fatty acid lipoxygenase ALOX150001
Polyunsaturated fatty acid lipoxygenase ALOX120001
Cannabinoid receptor 10101
Amine oxidase [flavin-containing] A0101
Alpha-1D adrenergic receptor0101
Leukotriene A-4 hydrolase0101
DNA (cytosine-5)-methyltransferase 10101
Amine oxidase [flavin-containing] B0202
Phosphatidylinositol 3-kinase regulatory subunit alpha0101
Proteasome subunit beta type-50101
Vascular endothelial growth factor receptor 20101
Receptor-type tyrosine-protein kinase FLT30101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform0101
Alpha-1A adrenergic receptor0101
E3 ubiquitin-protein ligase Mdm20101
Apoptosis regulator BAX 0011
Platelet-activating factor acetylhydrolase0101
Histone deacetylase 10101
Histone deacetylase 0101
Renin0101
Histone deacetylase 30101
Histone deacetylase-like amidohydrolase0213
Histone deacetylase 0101
HD2 type histone deacetylase HDA106 0202
Carboxypeptidase B20101
Histone-lysine N-methyltransferase EHMT20101
Histone deacetylase 70101
Histone deacetylase 6 0101
Histone deacetylase 40101
REST corepressor 30101
Nuclear receptor subfamily 1 group I member 20011
Histone deacetylase 0101
Nuclear receptor corepressor 20202
Histone deacetylase 60101
Histone deacetylase 0101
Carbonic anhydrase 20101
Translocator protein0101
Amine oxidase [flavin-containing] B0101
Carbonic anhydrase 30101
Amine oxidase [flavin-containing]0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]