Page last updated: 2024-08-24

triazoles and azomycin

triazoles has been researched along with azomycin in 68 studies

Research

Studies (68)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (4.41)	18.7374
1990's	2 (2.94)	18.2507
2000's	7 (10.29)	29.6817
2010's	47 (69.12)	24.3611
2020's	9 (13.24)	2.80

Authors

Authors	Studies
Abe, M; Ito, T; Kagiya, VT; Nishimoto, S; Sasai, K; Wang, J	1
Abe, M; Hisanaga, Y; Kagiya, T; Nishimoto, S; Sasai, K; Shibamoto, Y; Shimokawa, K; Takahashi, M; Wang, J; Zhou, L	1
Abe, M; Kagiya, T; Kimura, R; Nishidai, T; Nishimoto, S; Ono, K; Sakano, K; Shibamoto, Y	1
Morishima, I; Neya, S; Yonezawa, T	1
Nielsen, C; Pedersen, EB; Walczak, K	1
Brener, Z; Loebenberg, D; Martins-Filho, O; Molina, J; Romanha, AJ; Urbina, JA	1
Afonso, LC; Bahia, MT; Chiari, E; de Lana, M; Guedes, PM; Machado-Coelho, GL; Tafuri, WL; Urbina, JA; Veloso, VM	1
Basombrío, MA; Cardozo, R; Corrales, M; Segura, MA; Urbina, JA	1
Hori, H; Ito, M; Nagasawa, H; Ogino, H; Shibamoto, Y; Sugie, C; Suzuki, H; Uto, Y	1
Alves, RO; Ferraz, ML; Gazzinelli, RT; Romanha, AJ; Urbina, JA	2
Keshavarz, MH; Shokrolahi, A; Zali, A	1
Aerts, HJ; Brans, B; De Ruysscher, D; Dingemans, AM; Dubois, L; Hochstenbag, M; Janssen, MH; Kolb, H; Lalisang, R; Lambin, P; Ollers, M; van Dongen, GA; van Loon, J; Windhorst, B; Zhang, J	1
Araújo-Jorge, TC; Calvet, CM; de Castro, SL; Molina, JT; Olivieri, BP; Pereira, MC; Urbina, JA	1
Clayton, J	1
Alpaugh, K; Bélanger, MJ; Doss, M; Hostetler, ED; Kolb, HC; Stubbs, JB; Yu, JQ; Zhang, JJ	1
Barea, E; Caballero, AB; Marín, C; Ramírez-Macías, I; Rodríguez-Diéguez, A; Salas, JM; Sánchez-Moreno, M	1
Mugunthan, G; Ramakrishna, K; Ravindranathan Kartha, KP; Sriram, D; Yogeeswari, P	1
Le Loup, G; Lescure, FX; Pialoux, G	1
Bussink, J; Dubois, LJ; Janssen, MH; Kolb, HC; Lambin, P; Lieuwes, NG; Ollers, MC; Peeters, WJ; van der Kogel, A; van Dongen, GA; Walsh, JC; Windhorst, AD	1
Albesa, I; Becerra, MC; Gea, S; Guiñazú, N; Hergert, LY; Mazzieri, MR; Pellegrini, A	1
Bahia, MT; Buckner, FS; Charman, SA; Chatelain, E; Chennamaneni, NK; Gelb, MH; Hulverson, MA; Laydbak, JU; Lepesheva, GI; Scandale, I; Shackleford, DM; Suryadevara, PK; Verlinde, CL; White, KL	1
Carlin, S; Humm, JL	1
Chen, L; Guan, Y; Kolb, HC; Walsh, JC; Zhang, J; Zhang, Z	1
Carlier, Y; Cencig, S; Coltel, N; Truyens, C	1
Barrett, MP; Croft, SL	1
Aldasoro, E; Cortes-Lletget, C; Espinosa, G; Gállego, M; Gascon, J; Muñoz, J; Oliveira, I; Pinazo, MJ; Posada, Ede J	1
Aiub, CA; Araújo, JS; Batista, Dda G; Batista, MM; Britto, C; da Silva, CF; da Silva, PB; de Souza, EM; Hargrove, TY; Kim, K; Lepesheva, GI; Lionel, J; Pavão, BP; Soeiro, Mde N; Sulikowski, G; Waterman, MR	1
Bahia, MT; Caldas, IS; de Andrade, IM; Diniz, Lde F; Martins, TA; Mazzeti, AL; Ribeiro, I; Talvani, A; Urbina, JA	1
Blanco-Grau, A; Cabezos, J; Gómez i Prat, J; Molina, I; Pahissa, A; Pou, D; Roure, S; Salvador, F; Sánchez-Montalvá, A; Serre, N; Sulleiro, E; Treviño, B; Valerio, L; Vidal, X	1
Albajar-Viñas, P; Dias, JC	1
Molina, I; Salvador, F; Sánchez-Montalvá, A	1
Marin-Neto, JA; Rassi, A	1
Bestetti, RB; Restini, CB	1
Dubois, L; Eriksson, J; Lambin, P; Lieuwes, NG; Peeters, SG; van Dongen, GA; van Elmpt, W; Zegers, CM	1
Betts, HM; Dutton, D; Perkins, AC; Turton, DR	1
Biemans, R; Dubois, LJ; Hart, CP; Lambin, P; Lieuwes, NG; Peeters, SG; Sun, JD; van Elmpt, W; van Stiphout, RG; Windhorst, AD; Yaromina, A; Zegers, CM	1
Chatelain, E; Francisco, AF; Jayawardhana, S; Kelly, JM; Lewis, MD; Taylor, MC	1
Brunetti, JC; Chien, D; Kolb, H; Lambin, P; Moon, DH; Srinivas, SM; Subramaniam, RM; Szardenings, K; van Elmpt, W; Waxman, A; Zegers, CM	1
Mönnich, D; Thorwarth, D; Troost, EG; van Elmpt, W; Wack, LJ; Zegers, CM; Zips, D	1
Glynne, R; Groessl, T; Khare, S; Liu, X; Molteni, V; Rivera, I; Stinson, M; Supek, F; Tuntland, T; Wen, B; Yeh, V	1
Das, M; Dingemans, AC; Even, AJG; Lambin, P; Mottaghy, FM; Oellers, M; Reymen, B; Troost, EGC; van Elmpt, W; Wildberger, JE; Zegers, CML	1
Carneiro, ZA; Carvalho, I; Carvalho, MR; de Andrade, P; de Melo, EB; Galo, OA; Lopes, CD; Sesti-Costa, R; Silva, JS	1
Chu, T; Huang, H; Zhang, Q	1
Baillie, TA; Cyrus Khojasteh, S; Dalvie, D; Rietjens, IM	1
Botero, A; Keatley, S; Peacock, C; Thompson, RC	1
Apt, W; Beloscar, J; Bonilla, LR; Colombo, H; Cuneo, C; Del Carmen Bangher, M; Echeverria, LE; Gao, P; Gascon, J; Mallagray, M; McCarthy, M; Meeks, B; Milesi, R; Molina, I; Morillo, CA; Perez-Molina, JA; Sosa-Estani, S; Waskin, H; Wei, B; Wyss, F; Yusuf, S	1
Bern, C	1
Bahia, MT; Bloomer, WD; Gonçalves, KR; Mazzeti, AL; Mendes, PF; Papadopoulou, MV; Rosenzweig, HS	1
de La Roca Soares, MF; de Medeiros Vieira, ACQ; Figueirêdo, CBM; Lee, PI; Nadvorny, D; Rolim Neto, PJ; Soares Sobrinho, JL	1
Urbina, JA	1
Campos, MC; Clark, TG; Francisco, AF; Kelly, JM; Lewis, MD; Pain, A; Phelan, J; Taylor, MC	1
Alonso-Vega, C; Alves, F; Curto, MA; de la Barra, A; Flevaud, L; García, L; Gascón, J; Irazu, L; Molina, I; Ortiz, L; Parrado, R; Ramírez, JC; Ribeiro, I; Rodríguez, M; Schijman, AG; Sulleiro, E; Torrico, F; Villarroel, S	1
Almeida, IC; Alonso-Vega, C; Alves, F; Gascon, J; Ortiz, L; Pinazo, MJ; Ribeiro, I; Schijman, A; Strub-Wourgaft, N; Torrico, F	1
Bahia, MT; Caldas, IS; Diniz, LF; Mazzeti, AL; Ribeiro, I	1
Figueirêdo, CBM; Lee, PI; Nadvorny, D; Rolim Neto, PJ; Schver, GCRM; Soares Sobrinho, JL; Soares, MFR; Vieira, ACQM	1
Bastos, MM; Batista, DDGJ; Bianco, MDCAD; Boechat, N; da Gama, ANS; da Silva, CF; da Silva, PB; de Oliveira, AP; Fontes, FV; Hoelz, LVB; Leite, DI; Peres, RB; Soeiro, MNC; Villar, JDF	1
Betts, HM; Christian, JA; Foweraker, K; O'Connor, RA; Pascoe, AC; Perkins, AC; Vinayakamoorthy, V	1
Alonso-Vega, C; Alves, F; de la Barra, A; Flevaud, L; Garcia, L; Gascon, J; Illanes, D; Juiz, N; Ortiz, L; Parrado, R; Ramirez, JC; Ribeiro, I; Schijman, AG; Torrico, F	1
Díaz, ML; Echeverría, LE; Eduardo Nieto, J; González, CI; Hernandez, JCM; López-Romero, LA; Morillo, CA; Ochoa, SAG; Rivera, JD; Rojas, LZ; Suárez, EU	1
Bahia, MT; Caldas, IS; Diniz, LF; Machado, YA; Marques, MJ; Martins-Filho, OA; Mazzeti, AL; Novaes, RD; Santos, LJS; Vilas Boas, BR	1
Au, HYA; Bhattacharyya, T; Chatelain, E; Franco, CH; Freitas-Junior, LH; Giardini, MA; Le, H; Madeira, RP; Miles, MA; Moraes, CB; Pascoalino, BS; Romera, LMD; Schenkman, S; Torrecilhas, AC; Warhurst, DC	1
Braissant, O; Fesser, AF; Kaiser, M; Kelly, JM; Mäser, P; Olmo, F	1
Assunção, ELF; Baroni, ACM; Carvalho, DB; das Neves, AR; de Albuquerque, S; Kawasoko Shiguemotto, CY; Portapilla, GB	1
Bardach, A; Barreira, F; Ciapponi, A; Gascón, J; Molina, I; Morillo, C; Perelli, L; Prado, N; Riarte, A; Ribeiro, I; Sosa-Estani, S; Torrico, F; Villar, JC	1
Calvet, CM; Hirata, K; McKerrow, JH; Silva, TA; Siqueira-Neto, JL; Suzuki, B; Thomas, D	1
Acosta, N; Bobadilla, C; Escobar, P; Fernández, I; López, E; Ramírez, A; Yaluff, G	1
Almeida, IC; Alonso-Vega, C; Barboza, T; Barreira, F; Bilbe, G; Blum, B; Correia, E; Garcia, W; Gascón, J; Ortiz, L; Parrado, R; Ramirez, JC; Ribeiro, I; Sosa-Estani, S; Strub-Wourgaft, N; Torrico, F; Vaillant, M	1

Reviews

6 review(s) available for triazoles and azomycin

Article	Year
Update in treatment of Chagas disease. Current opinion in infectious diseases, 2011, Volume: 24, Issue:5 Topics: Chagas Disease; Chronic Disease; Humans; Immune Tolerance; Immunocompromised Host; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2011
PET of hypoxia: current and future perspectives. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2012, Volume: 53, Issue:8 Topics: Etanidazole; Humans; Hydrocarbons, Fluorinated; Hypoxia; Nitroimidazoles; Positron-Emission Tomography; Radioactive Tracers; Triazoles	2012
Management of trypanosomiasis and leishmaniasis. British medical bulletin, 2012, Volume: 104 Topics: Administration, Oral; Africa; Amphotericin B; Antiprotozoal Agents; Benzamides; Boron Compounds; Chagas Disease; Drug Therapy, Combination; Humans; India; Leishmaniasis; Nitroimidazoles; Pentamidine; Triazoles; Trypanosomiasis, African	2012
Immunosuppression and Chagas disease: a management challenge. PLoS neglected tropical diseases, 2013, Volume: 7, Issue:1 Topics: Adult; Antiprotozoal Agents; Chagas Disease; Female; Humans; Immunocompromised Host; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Opportunistic Infections; Triazoles; Trypanosoma cruzi	2013
Biotransformation and bioactivation reactions - 2015 literature highlights. Drug metabolism reviews, 2016, Volume: 48, Issue:2 Topics: Acetaminophen; Allylbenzene Derivatives; Aniline Compounds; Animals; Anisoles; Benzbromarone; Biotransformation; Humans; Imidazoles; Niacinamide; Nitroimidazoles; Nitrosamines; Oxazoles; Oxazolidinones; Peroxides; Pyrazines; Pyrazoles; Pyridazines; Pyridines; Pyridones; Pyrimidinones; Thiophenes; Triazoles	2016
Fixed vs adjusted-dose benznidazole for adults with chronic Chagas disease without cardiomyopathy: A systematic review and meta-analysis. PLoS neglected tropical diseases, 2020, Volume: 14, Issue:8 Topics: Adult; Cardiomyopathies; Chagas Disease; Databases, Factual; Humans; Nifurtimox; Nitroimidazoles; Patient Safety; Randomized Controlled Trials as Topic; Treatment Outcome; Triazoles; Trypanosoma cruzi	2020

Trials

9 trial(s) available for triazoles and azomycin

Article	Year
PET imaging of hypoxia using [18F]HX4: a phase I trial. European journal of nuclear medicine and molecular imaging, 2010, Volume: 37, Issue:9 Topics: Aged; Cell Hypoxia; Dose-Response Relationship, Drug; Female; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Neoplasms; Nitroimidazoles; Positron-Emission Tomography; Time Factors; Triazoles	2010
Biodistribution and radiation dosimetry of the hypoxia marker 18F-HX4 in monkeys and humans determined by using whole-body PET/CT. Nuclear medicine communications, 2010, Volume: 31, Issue:12 Topics: Animals; Biomarkers; Female; Haplorhini; Humans; Hypoxia; Male; Middle Aged; Nitroimidazoles; Positron-Emission Tomography; Radiometry; Radiopharmaceuticals; Species Specificity; Tomography, X-Ray Computed; Triazoles; Whole Body Imaging	2010
Randomized trial of posaconazole and benznidazole for chronic Chagas' disease. The New England journal of medicine, 2014, May-15, Volume: 370, Issue:20 Topics: Adult; Chagas Disease; Chronic Disease; DNA, Protozoan; Female; Humans; Intention to Treat Analysis; Male; Middle Aged; Nitroimidazoles; Prospective Studies; Transaminases; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2014
Repeatability of hypoxia PET imaging using [¹⁸F]HX4 in lung and head and neck cancer patients: a prospective multicenter trial. European journal of nuclear medicine and molecular imaging, 2015, Volume: 42, Issue:12 Topics: Aged; Biological Transport; Cell Hypoxia; Female; Head and Neck Neoplasms; Humans; Lung Neoplasms; Male; Middle Aged; Nitroimidazoles; Positron-Emission Tomography; Prospective Studies; Reproducibility of Results; Triazoles	2015
Multiparametric imaging of patient and tumour heterogeneity in non-small-cell lung cancer: quantification of tumour hypoxia, metabolism and perfusion. European journal of nuclear medicine and molecular imaging, 2016, Volume: 43, Issue:2 Topics: Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Female; Fluorodeoxyglucose F18; Humans; Lung Neoplasms; Male; Multimodal Imaging; Nitroimidazoles; Oxygen; Oxygen Consumption; Positron-Emission Tomography; Radiopharmaceuticals; Tomography, X-Ray Computed; Triazoles	2016
Benznidazole and Posaconazole in Eliminating Parasites in Asymptomatic T. Cruzi Carriers: The STOP-CHAGAS Trial. Journal of the American College of Cardiology, 2017, Feb-28, Volume: 69, Issue:8 Topics: Administration, Oral; Adult; Chagas Disease; Chronic Disease; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Nitroimidazoles; Prospective Studies; Single-Blind Method; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2017
Treatment of adult chronic indeterminate Chagas disease with benznidazole and three E1224 dosing regimens: a proof-of-concept, randomised, placebo-controlled trial. The Lancet. Infectious diseases, 2018, Volume: 18, Issue:4 Topics: Administration, Oral; Adolescent; Adult; Bolivia; Chagas Disease; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Incidence; Male; Middle Aged; Nitroimidazoles; Parasite Load; Placebos; Polymerase Chain Reaction; Prospective Studies; Thiazoles; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Young Adult	2018
Usefulness of Serial Blood Sampling and PCR Replicates for Treatment Monitoring of Patients with Chronic Chagas Disease. Antimicrobial agents and chemotherapy, 2019, Volume: 63, Issue:2 Topics: Adolescent; Adult; Chagas Disease; DNA, Protozoan; Humans; Middle Aged; Monitoring, Physiologic; Nitroimidazoles; Parasite Load; Placebos; Real-Time Polymerase Chain Reaction; Thiazoles; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Young Adult	2019
New regimens of benznidazole monotherapy and in combination with fosravuconazole for treatment of Chagas disease (BENDITA): a phase 2, double-blind, randomised trial. The Lancet. Infectious diseases, 2021, Volume: 21, Issue:8 Topics: Adult; Bolivia; Chagas Disease; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Nitroimidazoles; Parasite Load; Treatment Outcome; Triazoles; Young Adult	2021

Other Studies

53 other study(ies) available for triazoles and azomycin

Article	Year
Fluorine modification of nitroazole radiosensitizers for the enhancement of sensitizing activity with lowering toxicity: a pharmacokinetic characterization. International journal of radiation oncology, biology, physics, 1992, Volume: 22, Issue:3 Topics: Animals; Brain; Combined Modality Therapy; Female; Lethal Dose 50; Mice; Mice, Inbred C3H; Mice, Inbred ICR; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Triazoles	1992
Characteristics of fluorinated nitroazoles as hypoxic cell radiosensitizers. International journal of radiation oncology, biology, physics, 1989, Volume: 16, Issue:4 Topics: Animals; Cell Survival; Combined Modality Therapy; Hydrocarbons, Fluorinated; In Vitro Techniques; Lethal Dose 50; Mice; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Triazoles	1989
Radiosensitization in vitro and in vivo by 3-nitrotriazoles. International journal of radiation oncology, biology, physics, 1986, Volume: 12, Issue:7 Topics: Animals; Combined Modality Therapy; Cricetinae; Female; In Vitro Techniques; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Neoplasm Transplantation; Neoplasms, Experimental; Nitro Compounds; Nitroimidazoles; Radiation-Sensitizing Agents; Triazoles	1986
Proton NMR study of hemoproteins. Ionization and orientation of iron-bound imidazole in methemoglobin and metmyoblobin. Biochimica et biophysica acta, 1980, Feb-27, Volume: 621, Issue:2 Topics: Animals; Hemeproteins; Horses; Hydrogen-Ion Concentration; Imidazoles; Iron; Magnetic Resonance Spectroscopy; Methemoglobin; Metmyoglobin; Nitroimidazoles; Stereoisomerism; Temperature; Triazoles; Whales	1980
Synthesis of 3'-azolyl-2',3'-dideoxyhexose nucleosides. Acta chemica Scandinavica (Copenhagen, Denmark : 1989), 1998, Volume: 52, Issue:7 Topics: Antiviral Agents; Chromatography, High Pressure Liquid; Hexoses; HIV-1; Humans; Magnetic Resonance Spectroscopy; Nitroimidazoles; Nucleosides; Triazoles	1998
Activities of the triazole derivative SCH 56592 (posaconazole) against drug-resistant strains of the protozoan parasite Trypanosoma (Schizotrypanum) cruzi in immunocompetent and immunosuppressed murine hosts. Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:1 Topics: Acute Disease; Animals; Chagas Disease; Chronic Disease; Drug Resistance; Female; Immunocompetence; Immunosuppression Therapy; Mice; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2000
Activity of the new triazole derivative albaconazole against Trypanosoma (Schizotrypanum) cruzi in dog hosts. Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:11 Topics: Animals; Chagas Disease; Dogs; Enzyme-Linked Immunosorbent Assay; Immunoglobulin G; Monocytes; Nifurtimox; Nitroimidazoles; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2004
Comparative efficacies of TAK-187, a long-lasting ergosterol biosynthesis inhibitor, and benznidazole in preventing cardiac damage in a murine model of Chagas' disease. Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:4 Topics: Acute Disease; Animals; Chagas Cardiomyopathy; Chagas Disease; Disease Models, Animal; Ergosterol; Male; Mice; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2005
Reevaluation of the radiosensitizing effects of sanazole and nimorazole in vitro and in vivo. Journal of radiation research, 2005, Volume: 46, Issue:4 Topics: Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Evaluation, Preclinical; Female; Mice; Nimorazole; Nitroimidazoles; Radiation Tolerance; Radiation-Sensitizing Agents; Treatment Outcome; Triazoles	2005
The Anti-Trypanosoma cruzi activity of posaconazole in a murine model of acute Chagas' disease is less dependent on gamma interferon than that of benznidazole. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:4 Topics: Animals; Chagas Disease; Interferon-gamma; Interleukin-12; Mice; Mice, Inbred C57BL; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2007
Absence of CD4+ T lymphocytes, CD8+ T lymphocytes, or B lymphocytes has different effects on the efficacy of posaconazole and benznidazole in treatment of experimental acute Trypanosoma cruzi infection. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:1 Topics: Animals; B-Lymphocytes; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chagas Disease; Male; Mice; Mice, Knockout; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2009
A simple approach for predicting impact sensitivity of polynitroheteroarenes. Journal of hazardous materials, 2009, Jul-30, Volume: 166, Issue:2-3 Topics: Explosions; Explosive Agents; Heterocyclic Compounds, 1-Ring; Materials Testing; Models, Theoretical; Neural Networks, Computer; Nitro Compounds; Nitrofurans; Nitroimidazoles; Oxadiazoles; Pyrazoles; Pyridines; Pyrimidines; Structure-Activity Relationship; Triazoles	2009
A comparative study of posaconazole and benznidazole in the prevention of heart damage and promotion of trypanocidal immune response in a murine model of Chagas disease. International journal of antimicrobial agents, 2010, Volume: 36, Issue:1 Topics: Animals; Antiprotozoal Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chagas Cardiomyopathy; Chagas Disease; Disease Models, Animal; Female; Heart; Humans; Mice; Myocardium; Nitroimidazoles; Survival Analysis; Triazoles; Trypanosoma cruzi	2010
Chagas disease: pushing through the pipeline. Nature, 2010, Jun-24, Volume: 465, Issue:7301 Topics: Adult; Animals; Chagas Disease; Child; Chronic Disease; Clinical Trials as Topic; Drug Evaluation, Preclinical; Female; Humans; Infant, Newborn; Lupus Erythematosus, Systemic; Molecular Targeted Therapy; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Young Adult	2010
In vitro and in vivo antiparasital activity against Trypanosoma cruzi of three novel 5-methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one-based complexes. Journal of inorganic biochemistry, 2011, Volume: 105, Issue:6 Topics: Animals; Chagas Disease; Chlorocebus aethiops; Coordination Complexes; Crystallography, X-Ray; Female; Ligands; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Nitroimidazoles; Perchlorates; Pyrimidinones; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells	2011
Synthesis and screening of galactose-linked nitroimidazoles and triazoles against Mycobacterium tuberculosis. European journal of medicinal chemistry, 2011, Volume: 46, Issue:9 Topics: Galactose; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Nitroimidazoles; Triazoles	2011
Preclinical evaluation and validation of [18F]HX4, a promising hypoxia marker for PET imaging. Proceedings of the National Academy of Sciences of the United States of America, 2011, Aug-30, Volume: 108, Issue:35 Topics: Animals; Biomarkers; Cell Hypoxia; Fluorine Radioisotopes; Imidazoles; Male; Neoplasms, Experimental; Nitroimidazoles; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Triazoles	2011
In vitro activity of N-benzenesulfonylbenzotriazole on Trypanosoma cruzi epimastigote and trypomastigote forms. Experimental parasitology, 2012, Volume: 131, Issue:1 Topics: Animals; Cell Line; Cell Survival; Chagas Disease; Erythrocytes; Humans; Inhibitory Concentration 50; Macrophages; Mice; Mice, Inbred BALB C; Nitroimidazoles; Sulfonamides; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2012
Pharmacological characterization, structural studies, and in vivo activities of anti-Chagas disease lead compounds derived from tipifarnib. Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:9 Topics: 14-alpha Demethylase Inhibitors; Administration, Oral; Alkyl and Aryl Transferases; Animals; Chagas Disease; Crystallography, X-Ray; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Administration Schedule; Female; Humans; Mice; Models, Molecular; Nitroimidazoles; Quinolones; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2012
¹⁸F-HX4 hypoxia imaging with PET/CT in head and neck cancer: a comparison with ¹⁸F-FMISO. Nuclear medicine communications, 2012, Volume: 33, Issue:10 Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Cell Hypoxia; Feasibility Studies; Female; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Humans; Male; Middle Aged; Misonidazole; Multimodal Imaging; Nitroimidazoles; Positron-Emission Tomography; Tomography, X-Ray Computed; Triazoles	2012
Evaluation of benznidazole treatment combined with nifurtimox, posaconazole or AmBisome® in mice infected with Trypanosoma cruzi strains. International journal of antimicrobial agents, 2012, Volume: 40, Issue:6 Topics: Amphotericin B; Animals; Chagas Disease; Disease Models, Animal; DNA, Protozoan; Drug Therapy, Combination; Female; Mice; Mice, Inbred BALB C; Nifurtimox; Nitroimidazoles; Parasite Load; Parasitemia; Real-Time Polymerase Chain Reaction; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2012
In vitro and in vivo studies of the antiparasitic activity of sterol 14α-demethylase (CYP51) inhibitor VNI against drug-resistant strains of Trypanosoma cruzi. Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:9 Topics: 14-alpha Demethylase Inhibitors; Animals; Chagas Disease; Drug Resistance; Endoplasmic Reticulum; Golgi Apparatus; Imidazoles; Male; Mice; Microscopy, Electron, Transmission; Nitroimidazoles; Oxadiazoles; Protozoan Proteins; Sterol 14-Demethylase; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2013
Benznidazole and posaconazole in experimental Chagas disease: positive interaction in concomitant and sequential treatments. PLoS neglected tropical diseases, 2013, Volume: 7, Issue:8 Topics: Animals; Antiprotozoal Agents; Chagas Disease; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Mice; Nitroimidazoles; Parasitemia; Treatment Outcome; Triazoles; Trypanosoma cruzi	2013
Advancing the treatment for Chagas' disease. The New England journal of medicine, 2014, May-15, Volume: 370, Issue:20 Topics: Chagas Disease; Female; Humans; Male; Nitroimidazoles; Triazoles; Trypanocidal Agents	2014
Posaconazole versus benznidazole for chronic Chagas' disease. The New England journal of medicine, 2014, 09-04, Volume: 371, Issue:10 Topics: Chagas Disease; Female; Humans; Male; Nitroimidazoles; Triazoles; Trypanocidal Agents	2014
Posaconazole versus benznidazole for chronic Chagas' disease. The New England journal of medicine, 2014, 09-04, Volume: 371, Issue:10 Topics: Chagas Disease; Female; Humans; Male; Nitroimidazoles; Triazoles; Trypanocidal Agents	2014
Posaconazole versus benznidazole for chronic Chagas' disease. The New England journal of medicine, 2014, 09-04, Volume: 371, Issue:10 Topics: Chagas Disease; Female; Humans; Male; Nitroimidazoles; Triazoles; Trypanocidal Agents	2014
A comparative study of the hypoxia PET tracers [¹⁸F]HX4, [¹⁸F]FAZA, and [¹⁸F]FMISO in a preclinical tumor model. International journal of radiation oncology, biology, physics, 2015, Feb-01, Volume: 91, Issue:2 Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Computer Simulation; Imidazoles; Misonidazole; Models, Biological; Nitroimidazoles; Oxygen; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Reproducibility of Results; Rhabdomyosarcoma; Sensitivity and Specificity; Triazoles	2015
Automated radiosynthesis of GMP quality [18F]HX4 for PET imaging of hypoxia. Nuclear medicine and biology, 2015, Volume: 42, Issue:5 Topics: Automation; Hypoxia; Nitroimidazoles; Positron-Emission Tomography; Quality Control; Radiochemistry; Triazoles	2015
TH-302 in Combination with Radiotherapy Enhances the Therapeutic Outcome and Is Associated with Pretreatment [18F]HX4 Hypoxia PET Imaging. Clinical cancer research : an official journal of the American Association for Cancer Research, 2015, Jul-01, Volume: 21, Issue:13 Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Chemoradiotherapy; Imidazoles; Lung Neoplasms; Nitroimidazoles; Phosphoramide Mustards; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Treatment Outcome; Triazoles; Xenograft Model Antitumor Assays	2015
Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging. Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:8 Topics: Animals; Antifungal Agents; Chagas Disease; Chronic Disease; Disease Models, Animal; Female; Mice; Mice, Inbred BALB C; Mice, SCID; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2015
Comparison of [18F]-FMISO, [18F]-FAZA and [18F]-HX4 for PET imaging of hypoxia--a simulation study. Acta oncologica (Stockholm, Sweden), 2015, Volume: 54, Issue:9 Topics: Humans; Hypoxia; Imidazoles; Misonidazole; Models, Theoretical; Nitroimidazoles; Positron-Emission Tomography; Radiopharmaceuticals; Triazoles	2015
Antitrypanosomal Treatment with Benznidazole Is Superior to Posaconazole Regimens in Mouse Models of Chagas Disease. Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:10 Topics: 14-alpha Demethylase Inhibitors; Administration, Oral; Animals; Chagas Disease; Clinical Trials, Phase II as Topic; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Heart; Humans; Immunosuppression Therapy; Mice; NIH 3T3 Cells; Nitroimidazoles; Parasitemia; Recurrence; Sterol 14-Demethylase; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2015
1,2,3-Triazole-based analogue of benznidazole displays remarkable activity against Trypanosoma cruzi. Bioorganic & medicinal chemistry, 2015, Nov-01, Volume: 23, Issue:21 Topics: Catalysis; Click Chemistry; Copper; Cycloaddition Reaction; Microwaves; Nitroimidazoles; Ruthenium; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2015
In vitro and in vivo evaluation of technetium-99m-labeled propylene amine oxime complexes containing nitroimidazole and nitrotriazole groups as hypoxia markers. Journal of labelled compounds & radiopharmaceuticals, 2016, Volume: 59, Issue:1 Topics: Animals; Cell Line, Tumor; Hypoxia; Male; Mice; Nitroimidazoles; Organotechnetium Compounds; Oximes; Radionuclide Imaging; Radiopharmaceuticals; Tissue Distribution; Triazoles	2016
In vitro drug susceptibility of two strains of the wildlife trypanosome, Trypanosoma copemani: A comparison with Trypanosoma cruzi. International journal for parasitology. Drugs and drug resistance, 2017, Volume: 7, Issue:1 Topics: Animals; Animals, Wild; Australia; Cell Line; Drug Discovery; High-Throughput Screening Assays; Inhibitory Concentration 50; Melarsoprol; Nitroimidazoles; Phosphorylcholine; Potoroidae; Pyrimidines; Triazoles; Trypanocidal Agents; Trypanosoma; Trypanosoma cruzi	2017
A New Epoch in Antitrypanosomal Treatment for Chagas Disease. Journal of the American College of Cardiology, 2017, 02-28, Volume: 69, Issue:8 Topics: Animals; Chagas Disease; Nitroimidazoles; Parasites; Triazoles	2017
Nitrotriazole-Based Compounds as Antichagasic Agents in a Long-Treatment Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:5 Topics: Animals; Chagas Disease; Dose-Response Relationship, Drug; Female; Mice; Nitroimidazoles; Parasitemia; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2017
Enhancement of dissolution rate through eutectic mixture and solid solution of posaconazole and benznidazole. International journal of pharmaceutics, 2017, Jun-15, Volume: 525, Issue:1 Topics: Drug Combinations; Drug Compounding; Nitroimidazoles; Solubility; Triazoles	2017
Pharmacodynamics and Follow-Up Period in the Treatment of Human Trypanosoma Cruzi Infections With Posaconazole. Journal of the American College of Cardiology, 2017, 07-11, Volume: 70, Issue:2 Topics: Animals; Chagas Disease; Follow-Up Studies; Humans; Nitroimidazoles; Parasites; Triazoles	2017
Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole. Scientific reports, 2017, 10-31, Volume: 7, Issue:1 Topics: Animals; Chagas Disease; Disease Models, Animal; Drug Resistance, Multiple; Female; Genome, Protozoan; Mice, SCID; Mutagenesis; Mutagens; Mutation; Nitroimidazoles; Sequence Analysis, DNA; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2017
First external quality assurance program for bloodstream Real-Time PCR monitoring of treatment response in clinical trials of Chagas disease. PloS one, 2017, Volume: 12, Issue:11 Topics: Chagas Disease; Humans; Monitoring, Physiologic; Nitroimidazoles; Real-Time Polymerase Chain Reaction; Triazoles; Trypanocidal Agents	2017
Outcome of E1224-Benznidazole Combination Treatment for Infection with a Multidrug-Resistant Trypanosoma cruzi Strain in Mice. Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:6 Topics: Animals; Combined Modality Therapy; Disease Models, Animal; Drug Interactions; Female; Mice; Microbial Sensitivity Tests; Nitroimidazoles; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2018
Enhanced delivery of fixed-dose combination of synergistic antichagasic agents posaconazole-benznidazole based on amorphous solid dispersions. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2018, Jul-01, Volume: 119 Topics: Biological Availability; Chagas Disease; Drug Carriers; Drug Combinations; Drug Liberation; Drug Synergism; Models, Molecular; Nitroimidazoles; Povidone; Pyrrolidines; Triazoles; Trypanocidal Agents; Vinyl Compounds	2018
New 1,2,3-triazole-based analogues of benznidazole for use against Trypanosoma cruzi infection: In vitro and in vivo evaluations. Chemical biology & drug design, 2018, Volume: 92, Issue:3 Topics: Animals; Cell Line; Cell Survival; Chagas Disease; Male; Mice; Nifurtimox; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2018
Hypoxia imaging with [18F]HX4 PET in squamous cell head and neck cancers: a pilot study for integration into treatment planning. Nuclear medicine communications, 2019, Volume: 40, Issue:1 Topics: Aged; Chemoradiotherapy; Female; Humans; Male; Middle Aged; Nitroimidazoles; Pilot Projects; Positron-Emission Tomography; Radiotherapy Planning, Computer-Assisted; Squamous Cell Carcinoma of Head and Neck; Triazoles; Tumor Hypoxia	2019
Efficacy of the Benznidazole+Posaconazole combination therapy in parasitemia reduction: An experimental murine model of acute Chagas. Revista da Sociedade Brasileira de Medicina Tropical, 2020, Volume: 53 Topics: Acute Disease; Animals; Chagas Disease; Disease Models, Animal; Disease Progression; DNA, Protozoan; Drug Therapy, Combination; Nitroimidazoles; Parasite Load; Parasitemia; Rats; Rats, Wistar; Triazoles; Trypanocidal Agents	2020
Amlodipine Increases the Therapeutic Potential of Ravuconazole upon Trypanosoma cruzi Infection. Antimicrobial agents and chemotherapy, 2020, 07-22, Volume: 64, Issue:8 Topics: Amlodipine; Animals; Chagas Disease; Mice; Nitroimidazoles; Parasitemia; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2020
Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity. International journal for parasitology. Drugs and drug resistance, 2020, Volume: 13 Topics: 14-alpha Demethylase Inhibitors; Animals; Cell Line; Chagas Disease; Drug Resistance, Multiple; Genes, Protozoan; Mutation; Nitroimidazoles; Sterol 14-Demethylase; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2020
Non-invasive monitoring of drug action: A new live in vitro assay design for Chagas' disease drug discovery. PLoS neglected tropical diseases, 2020, Volume: 14, Issue:7 Topics: Chagas Disease; Drug Discovery; Humans; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2020
Synthesis and Antitrypanosomal Activity of 1,4-Disubstituted Triazole Compounds Based on a 2-Nitroimidazole Scaffold: a Structure-Activity Relationship Study. ChemMedChem, 2020, 11-04, Volume: 15, Issue:21 Topics: Animals; Cells, Cultured; Macaca mulatta; Molecular Structure; Nitroimidazoles; Parasitic Sensitivity Tests; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2020
Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole. PLoS neglected tropical diseases, 2020, Volume: 14, Issue:9 Topics: Administration, Oral; Animals; Chagas Disease; Disease Models, Animal; Follow-Up Studies; Male; Mice, Inbred C57BL; Nitroimidazoles; Polymerase Chain Reaction; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2020
In vitro susceptibility to benznidazole, nifurtimox and posaconazole of Trypanosoma cruzi isolates from Paraguay Biomedica : revista del Instituto Nacional de Salud, 2020, 12-02, Volume: 40, Issue:4 Topics: Analysis of Variance; Genotype; Lethal Dose 50; Nifurtimox; Nitroimidazoles; Paraguay; Phenotype; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2020