Page last updated: 2024-12-07

l-phenylalanine ethylester

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

L-phenylalanine ethyl ester is a derivative of the amino acid phenylalanine. It is synthesized by reacting phenylalanine with ethanol in the presence of an acid catalyst. L-phenylalanine ethyl ester is a potent inhibitor of the enzyme monoamine oxidase (MAO), which is involved in the breakdown of neurotransmitters such as dopamine, norepinephrine, and serotonin. This inhibitory effect makes l-phenylalanine ethylester a potential therapeutic agent for the treatment of depression, anxiety, and other neuropsychiatric disorders. It is also under investigation for its potential as an anti-inflammatory and analgesic agent. L-phenylalanine ethyl ester is studied because of its potential therapeutic applications and its role in understanding the mechanisms of neurotransmission and enzyme inhibition.'

L-phenylalanine ethylester: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID102688
SCHEMBL ID616963
MeSH IDM0492254

Synonyms (21)

Synonym
TIMTEC1_001063
NCGC00174833-01
BRD-A06475750-003-01-1
ethyl 2-amino-3-phenylpropanoate
STL256235
ethyl 3-phenyl-dl-alaninate
einecs 217-278-6
1795-96-6
AKOS022108093
AB00375579-03
ethyl 2-amino-3-phenyl-propionate
ethyl 2-amino-3-phenylpropionate
CJGXMNONHNZEQQ-UHFFFAOYSA-N
SCHEMBL616963
l-phenylalanine ethylester
h-phe-oet hcl
NCGC00174833-02
EN300-57346
mfcd11183436
ethyl2-amino-3-phenylpropanoate
F78542

Research Excerpts

Toxicity

ExcerptReferenceRelevance
"01) and had no side effects or toxic effects on the thymus index (P>0."( Fabrication of novel vesicles of triptolide for antirheumatoid activity with reduced toxicity in vitro and in vivo.
Huang, J; Li, J; Li, Q; Liang, Q; Wang, T; Wang, Y; Xu, H; Zhang, L, 2016
)
0.43
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).2014Journal of biomolecular screening, Jul, Volume: 19, Issue:6
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (15.38)18.7374
1990's0 (0.00)18.2507
2000's2 (15.38)29.6817
2010's7 (53.85)24.3611
2020's2 (15.38)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 24.80

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index24.80 (24.57)
Research Supply Index2.71 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index22.84 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (24.80)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other14 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]