Compounds > oxadixyl
Page last updated: 2024-12-06

oxadixyl

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Oxadixyl is a fungicide that is used to control a variety of diseases in crops. It is a member of the oxathiin carboxamide class of fungicides and has a broad spectrum of activity against fungi. Oxadixyl is a systemic fungicide, meaning that it is absorbed by the plant and translocated throughout the plant, providing protection from fungal infections. It is effective against a wide range of fungal diseases, including downy mildew, powdery mildew, rust, and leaf spot. Oxadixyl is applied to crops as a foliar spray, and it is also available in formulations that can be mixed with water and applied to the soil. Oxadixyl is a relatively safe fungicide and has been approved for use in a number of countries around the world. However, it is important to follow the instructions on the label and to use it only as directed. The compound is typically used as a preventive treatment, and it is not as effective against established infections. Oxadixyl is thought to work by inhibiting the growth of fungal cells. Specifically, it is believed to disrupt the synthesis of fungal DNA, which is essential for the growth and development of the fungi. Oxadixyl has been studied extensively, and it has been shown to be effective in controlling a wide range of fungal diseases. It is also a relatively safe fungicide, and it has been approved for use in many countries. However, it is important to follow the instructions on the label and to use it only as directed. Oxadixyl is a relatively new fungicide, and it is important to continue to monitor its safety and effectiveness over time.'

oxadixyl: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

oxadixyl : An oxazolidinone that is N-(2,6-dimethylphenyl)-2-methoxyacetamide in which the amide hydrogen is replaced by a 2-oxo-1,3-oxazolidin-3-yl group. A systemic fungicide used to treat seeds of a variety of food crops, as well as lawns. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID53735
CHEMBL ID1864998
CHEBI ID81937
SCHEMBL ID6304
MeSH IDM0172672

Synonyms (48)

Synonym
wakil
oxadixyl
acetamide, n-(2,6-dimethylphenyl)-2-methoxy-n-(2-oxo-3-oxazolidinyl)-
2-methoxy-n-(2-oxo-1,3-oxazolidine-3-yl)-acet-2,6-xylidine [french]
san 371
2-methoxy-n-(2-oxo-1,3-oxazolidin-3-yl)acet-2',6'-xylidide
sandofan
n-(2,6-dimethylphenyl)-2-methoxy-n-(2-oxo-3-oxazolidinyl)acetamide
san 371f
recoil
oxadixyl [bsi:iso]
m 10797
ripost
NCGC00164271-01
n-(2,6-dimethylphenyl)-2-methoxy-n-(2-oxo-1,3-oxazolidin-3-yl)acetamide
77732-09-3
C18753
236cma8a12 ,
unii-236cma8a12
2-methoxy-n-(2-oxo-1,3-oxazolidine-3-yl)-acet-2,6-xylidine
cas-77732-09-3
dtxsid2032631 ,
NCGC00255297-01
tox21_301853
dtxcid0012631
FT-0630856
AKOS015902934
san-371f
oxadixyl [mi]
oxadixyl [iso]
SCHEMBL6304
CHEBI:81937 ,
n-(2,6-dimethylphenyl)-2-methoxy-n-(2-oxooxazolidin-3-yl)acetamide
2-methoxy-n-(2,6-dimethylphenyl)-n-(2-oxo-3-oxazolidinyl)-acetamide
CHEMBL1864998
anchor
n-(2,6-dimethylphenyl)-2-methoxy-n-(2-oxo-1,3-oxazolidin-3-yl)acetamide #
oxadixyl, pestanal(r), analytical standard
oxadixyl 10 microg/ml in cyclohexane
oxadixyl 100 microg/ml in acetone
oxadixyl 10 microg/ml in acetonitrile
oxadixyl;sandofan
3-[bis(2-hydroxyethyl)amino]benzanilide
Q19297826
m10797
m-10797
CDA73209
CS-W020896

Research Excerpts

Overview

Oxadixyl is a systemic phenylamide fungicide. Used to prevent and control disease caused by phytophthora and downy mildew in cash crops.

ExcerptReferenceRelevance
"Oxadixyl is a systemic phenylamide fungicide, used to prevent and control disease caused by phytophthora and downy mildew in a variety of cash crops. "( An immunochromatographic assay for the rapid detection of oxadixyl in cucumber, tomato and wine samples.
Kuang, H; Liu, J; Liu, L; Song, S; Sun, M; Wang, Z; Wu, A; Xu, C; Xu, L; Xu, X, 2022)		2.41

Bioavailability

ExcerptReferenceRelevance
" The mobility of pesticides in soil, bioavailability and transfer to other environmental compartments depend on sorption and desorption kinetics and mechanisms."( Leaching of oxadyxil and tebuconazole in Colombian soil.
Aldana, M; De Prado, R; Martínez, MJ, 2011)		0.37
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
agrochemicalAn agrochemical is a substance that is used in agriculture or horticulture.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (5)

ClassDescription
aromatic amideAn amide in which the amide linkage is bonded directly to an aromatic system.
oxazolidinoneAn oxazolidine containing one or more oxo groups.
carbohydrazideA hydrazide consisting of hydrazine carrying one or more carboacyl groups.
etherAn organooxygen compound with formula ROR, where R is not hydrogen.
anilide fungicideAny amide fungicide whose structure contains an anilide group.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (3)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
AR proteinHomo sapiens (human)Potency0.00560.000221.22318,912.5098AID588515
estrogen nuclear receptor alphaHomo sapiens (human)Potency1.23000.000229.305416,493.5996AID743075
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency1.25890.010039.53711,122.0200AID588547
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (20.00)18.7374
1990's1 (20.00)18.2507
2000's1 (20.00)29.6817
2010's1 (20.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 34.49

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index34.49 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.80 (4.65)
Search Engine Demand Index42.91 (26.88)
Search Engine Supply Index2.14 (0.95)

This Compound (34.49)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
alachlor
alachlor : An aromatic amide that is N-(2,6-diethylphenyl)acetamide substituted by a methoxymethyl group at at the nitrogen atom while one of the hydrogens of the methyl group has been replaced by a chlorine atom.		6.9710aromatic amide;
monocarboxylic acid amide;
organochlorine compound		environmental contaminant;
herbicide;
xenobiotic
alanine
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.. alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.		2.0110alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid		EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite
oxazoles
Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.		3.11501,3-oxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
metalaxyl
metalaxyl: RN given refers to (DL-Ala)-isomer. metalaxyl : A racemate comprising equal amounts of (R)- and (S)-metalaxyl. A systemic fungicide, it is active against phytopathogens of the order Peronosporales and is used to conrtrol Pythium in a number of vegetable crops.. methyl N-(2,6-dimethylphenyl)-N-(methoxyacetyl)alaninate : An alanine derivative that is methyl alaninate in which one of the hydrogens attached to the nitrogen is substituted by a methoxyacetyl group, while the other is substituted by a 2,6-dimethylphenyl group.		2.0110alanine derivative;
aromatic amide;
carboxamide;
ether;
methyl ester
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		2.06101,2,3-triazole
tebuconazole
Lynx: A genus in the family FELIDAE comprising felines with long legs, ear tufts, and a short tail.. 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol : A tertiary alcohol that is pentan-3-ol substituted by a 4-chlorophenyl, methyl, methyl, and a 1H-1,2,4-triazol-1-ylmethyl at positions 1, 4, 4 and 3 respectively.. tebuconazole : A racemate composed of equimolar amounts of (R)- and (S)-tebuconazole. A fungicide effective against various smut and bunt diseases in cereals and other field crops.		2.0610monochlorobenzenes;
tertiary alcohol;
triazoles
2-cyano-n-((ethylamino)carbonyl)-2-(methoxyimino)acetamide
2-cyano-N-((ethylamino)carbonyl)-2-(methoxyimino)acetamide: RN given refers to parent cpd; structure in first source		2.0110
dimethomorph
dimethomorph: structure given in first source; RN given refers to cpd without isomeric designation. (Z)-dimethomorph : An enamide resulting from the formal condensation of (2Z)-3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)acrylic acid with the amino group of morpholine. The agricultural fungicide dimethomorph is a mixture of (E)- and (Z)-dimethomorph; only the Z isomer has fungicidal activity.. dimethomorph : A mixture of (E)- and (Z)-dimethomorph in an unspecified ratio. It is used as a systemic fungicide used on vines, potatoes, and greenhouse crops; only the Z isomer has fungicidal activity.		2.0110aromatic ether;
enamide;
monochlorobenzenes;
morpholine fungicide;
tertiary carboxamide
ConditionIndicatedRelationship StrengthStudiesTrials