Assay ID | Title | Year | Journal | Article |
AID593504 | Antiviral activity against wild type HIV1 3B infected in human CEM cells assessed as inhibition of syncytia formation | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
AID593508 | Antiviral activity against HIV1 3B harboring reverse transcriptase E138K mutant infected in human CEM cells assessed as inhibition of syncytia formation | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
AID593505 | Antiviral activity against HIV1 3B harboring reverse transcriptase K103N mutant infected in human CEM cells assessed as inhibition of syncytia formation | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
AID593602 | Inhibition of HIV-1 reverse transcriptase K1001E and E138K mutant-mediated polymerization reaction after 30 mins | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
AID619908 | Antiviral activity against HIV1 harboring reverse transcriptase E138K mutant infected in human CEM cells assessed as inhibition of virus-induced cytopathicity after 4 days | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Synthesis and in vitro activity of novel N-3 acylated TSAO-T compounds against HIV-1 and HCV. |
AID593702 | Ratio of IC50 for HIV-1 reverse transcriptase K1001E and E138K mutant to IC50 for HIV-1 wild type reverse transcriptase | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
AID593698 | Ratio of EC50 for HIV1 3B harboring reverse transcriptase Y181I mutant to EC50 for wild type HIV1 3B | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
AID253508 | Concentration of compound inhibiting Lys103-Asn mutant HIV-1(IIIB) induced cytopathicity in CEM cell culture by 50% | 2005 | Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13
| First synthesis and evaluation of the inhibitory effects of aza analogues of TSAO on HIV-1 replication. |
AID593608 | Ratio of EC50 for HIV1 3B harboring reverse transcriptase N136A/Q/K mutant to EC50 for wild type HIV1 3B | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
AID593701 | Ratio of EC50 for HIV1 3B harboring reverse transcriptase G190E mutant to EC50 for wild type HIV1 3B | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
AID593612 | Ratio of EC50 for HIV1 3B harboring reverse transcriptase Y181C mutant to EC50 for wild type HIV1 3B | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
AID322454 | Antiviral activity against HIV1 3B in CEM cells assessed as inhibition of viral replication | 2008 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 18, Issue:7
| Synthesis, anti-HIV-1 activity, and modeling studies of N-3 Boc TSAO compound. |
AID593603 | Antiviral activity against wild type HIV1 infected in human CEM cells assessed as inhibition of syncytia formation | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
AID593611 | Ratio of EC50 for HIV1 3B harboring reverse transcriptase V179N mutant to EC50 for wild type HIV1 3B | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
AID245976 | Concentration of compound required to reduce by 50% the number of viable cells in mock infected MT-4 cell cultures | 2005 | Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13
| First synthesis and evaluation of the inhibitory effects of aza analogues of TSAO on HIV-1 replication. |
AID593503 | Antiviral activity against HIV1 3B harboring reverse transcriptase L100I mutant infected in human CEM cells assessed as inhibition of syncytia formation | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
AID246287 | Concentration of compound required to inhibit HIV-1(IIIB) induced cytopathicity in CEM cell culture by 50% | 2005 | Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13
| First synthesis and evaluation of the inhibitory effects of aza analogues of TSAO on HIV-1 replication. |
AID619903 | Antiviral activity against HIV1 3B infected in human CEM cells assessed as inhibition of virus-induced cytopathicity after 4 days | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Synthesis and in vitro activity of novel N-3 acylated TSAO-T compounds against HIV-1 and HCV. |
AID593599 | Inhibition of wild type HIV-1 reverse transcriptase-mediated polymerization reaction after 30 mins | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
AID268624 | Inhibition of HIV1 reverse transcriptase RNA-dependent DNA polymerase activity | 2006 | Journal of medicinal chemistry, Aug-10, Volume: 49, Issue:16
| Structure-activity relationships of [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5' '-(4' '-amino-1' ',2' '-oxathiole-2' ',2' '-dioxide)thymine derivatives as inhibitors of HIV-1 reverse transcriptase dimerization. |
AID593610 | Ratio of EC50 for HIV1 3B harboring reverse transcriptase E138D mutant to EC50 for wild type HIV1 3B | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
AID593509 | Antiviral activity against HIV1 3B harboring reverse transcriptase E138D mutant infected in human CEM cells assessed as inhibition of syncytia formation | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
AID593594 | Antiviral activity against HIV1 3B harboring reverse transcriptase Y181C mutant infected in human CEM cells assessed as inhibition of syncytia formation | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
AID593596 | Antiviral activity against HIV1 3B harboring reverse transcriptase Y188H mutant infected in human CEM cells assessed as inhibition of syncytia formation | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
AID619904 | Antiviral activity against HIV2 ROD infected in human CEM cells assessed as inhibition of virus-induced cytopathicity after 4 days | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Synthesis and in vitro activity of novel N-3 acylated TSAO-T compounds against HIV-1 and HCV. |
AID593598 | Antiviral activity against HIV1 3B harboring reverse transcriptase G190E mutant infected in human CEM cells assessed as inhibition of syncytia formation | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
AID619906 | Antiviral activity against HCV2a JFH1 infected in human Huh7 cells assessed as inhibition of viral replication after 72 hrs by luciferase reporter gene assay | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Synthesis and in vitro activity of novel N-3 acylated TSAO-T compounds against HIV-1 and HCV. |
AID593506 | Antiviral activity against HIV1 3B harboring reverse transcriptase V106A mutant infected in human CEM cells assessed as inhibition of syncytia formation | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
AID327202 | Antiviral activity against HIV2 ROD in CEM cells assessed as inhibition of virus-induced cytopathogenicity after 4 days | 2008 | Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8
| Synthesis and anti-HIV1 biological activity of novel 5''-ATSAO compounds. |
AID619905 | Cytotoxicity against human CEM cells after 4 days | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Synthesis and in vitro activity of novel N-3 acylated TSAO-T compounds against HIV-1 and HCV. |
AID81255 | Concentration required to inhibit HIV-1 induced cytopathicity in human MT-4 lymphocyte cells. | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| 3'-Spiro nucleosides, a new class of specific human immunodeficiency virus type 1 inhibitors: synthesis and antiviral activity of [2'-5'-bis-O-(tert-butyldimethylsilyl)-beta-D-xylo- and -ribofuranose]-3'-spiro-5"-[4"-amino-1",2"-oxathiole 2",2"-dioxide] ( |
AID619907 | Cytotoxicity against human HuH7 cells after 72 hrs | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Synthesis and in vitro activity of novel N-3 acylated TSAO-T compounds against HIV-1 and HCV. |
AID253510 | Concentration of compound inhibiting Tyr181- Cys mutant HIV-1(IIIB) induced cytopathicity in CEM cell culture by 50% | 2005 | Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13
| First synthesis and evaluation of the inhibitory effects of aza analogues of TSAO on HIV-1 replication. |
AID593507 | Antiviral activity against HIV1 3B harboring reverse transcriptase N136A/Q/K mutant infected in human CEM cells assessed as inhibition of syncytia formation | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
AID106589 | Concentration required to reduce human MT-4 cell viability by 50%. | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| 3'-Spiro nucleosides, a new class of specific human immunodeficiency virus type 1 inhibitors: synthesis and antiviral activity of [2'-5'-bis-O-(tert-butyldimethylsilyl)-beta-D-xylo- and -ribofuranose]-3'-spiro-5"-[4"-amino-1",2"-oxathiole 2",2"-dioxide] ( |
AID268626 | Inhibition of MT4 cell viability | 2006 | Journal of medicinal chemistry, Aug-10, Volume: 49, Issue:16
| Structure-activity relationships of [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5' '-(4' '-amino-1' ',2' '-oxathiole-2' ',2' '-dioxide)thymine derivatives as inhibitors of HIV-1 reverse transcriptase dimerization. |
AID322455 | Antiviral activity against HIV2 ROD in CEM cells assessed as inhibition of viral replication | 2008 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 18, Issue:7
| Synthesis, anti-HIV-1 activity, and modeling studies of N-3 Boc TSAO compound. |
AID593595 | Antiviral activity against HIV1 3B harboring reverse transcriptase Y181I mutant infected in human CEM cells assessed as inhibition of syncytia formation | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
AID593601 | Inhibition of HIV-1 reverse transcriptase E138K mutant-mediated polymerization reaction after 30 mins | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
AID245974 | Concentration of compound required to reduce by 50% the number of viable cells in mock infected CEM cell cultures | 2005 | Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13
| First synthesis and evaluation of the inhibitory effects of aza analogues of TSAO on HIV-1 replication. |
AID593609 | Ratio of EC50 for HIV1 3B harboring reverse transcriptase E138K mutant to EC50 for wild type HIV1 3B | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
AID327203 | Cytotoxicity against mock-infected human CEM cells assessed as reduction of cell viability after 4 days | 2008 | Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8
| Synthesis and anti-HIV1 biological activity of novel 5''-ATSAO compounds. |
AID268625 | Antiviral activity against HIV1 in MT4 cells | 2006 | Journal of medicinal chemistry, Aug-10, Volume: 49, Issue:16
| Structure-activity relationships of [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5' '-(4' '-amino-1' ',2' '-oxathiole-2' ',2' '-dioxide)thymine derivatives as inhibitors of HIV-1 reverse transcriptase dimerization. |
AID268623 | Inhibition of FLAG-p66/HIS-p51-mediated HIV1 reverse transcriptase dimerization | 2006 | Journal of medicinal chemistry, Aug-10, Volume: 49, Issue:16
| Structure-activity relationships of [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5' '-(4' '-amino-1' ',2' '-oxathiole-2' ',2' '-dioxide)thymine derivatives as inhibitors of HIV-1 reverse transcriptase dimerization. |
AID593606 | Ratio of EC50 for HIV1 3B harboring reverse transcriptase K103N mutant to EC50 for wild type HIV1 3B | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
AID322456 | Cytotoxicity against human CEM cells | 2008 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 18, Issue:7
| Synthesis, anti-HIV-1 activity, and modeling studies of N-3 Boc TSAO compound. |
AID246294 | Concentration of compound required to inhibit HIV-1(IIIB) induced cytopathicity in MT-4 cell culture by 50% | 2005 | Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13
| First synthesis and evaluation of the inhibitory effects of aza analogues of TSAO on HIV-1 replication. |
AID246295 | Concentration of compound required to inhibit HIV-2 (ROD) induced cytopathicity in MT-4 cell culture by 50% | 2005 | Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13
| First synthesis and evaluation of the inhibitory effects of aza analogues of TSAO on HIV-1 replication. |
AID327201 | Antiviral activity against HIV1 3B in CEM cells assessed as inhibition of virus-induced cytopathogenicity after 4 days | 2008 | Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8
| Synthesis and anti-HIV1 biological activity of novel 5''-ATSAO compounds. |
AID593600 | Inhibition of HIV-1 reverse transcriptase K101E mutant-mediated polymerization reaction after 30 mins | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
AID593699 | Ratio of EC50 for HIV1 3B harboring reverse transcriptase Y188H mutant to EC50 for wild type HIV1 3B | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
AID593510 | Antiviral activity against HIV1 3B harboring reverse transcriptase V179N mutant infected in human CEM cells assessed as inhibition of syncytia formation | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
AID235889 | Ratio of effective concentration to that of cytotoxic concentration against HIV-1 induced cytopathogenicity in MT-4 cells | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| 3'-Spiro nucleosides, a new class of specific human immunodeficiency virus type 1 inhibitors: synthesis and antiviral activity of [2'-5'-bis-O-(tert-butyldimethylsilyl)-beta-D-xylo- and -ribofuranose]-3'-spiro-5"-[4"-amino-1",2"-oxathiole 2",2"-dioxide] ( |
AID593700 | Ratio of EC50 for HIV1 3B harboring reverse transcriptase Y188L mutant to EC50 for wild type HIV1 3B | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
AID246288 | Concentration of compound required to inhibit HIV-2 (ROD) induced cytopathicity in CEM cell culture by 50% | 2005 | Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13
| First synthesis and evaluation of the inhibitory effects of aza analogues of TSAO on HIV-1 replication. |
AID593604 | Antiviral activity against wild type HIV2 infected in human CEM cells assessed as inhibition of syncytia formation | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
AID593597 | Antiviral activity against HIV1 3B harboring reverse transcriptase Y188L mutant infected in human CEM cells assessed as inhibition of syncytia formation | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
AID593607 | Ratio of EC50 for HIV1 3B harboring reverse transcriptase V106A mutant to EC50 for wild type HIV1 3B | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
AID593605 | Ratio of EC50 for HIV1 3B harboring reverse transcriptase L100I mutant to EC50 for wild type HIV1 3B | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
AID253507 | Concentration of compound inhibiting Glu138-Lys mutant HIV-1(IIIB) induced cytopathicity in CEM cell culture by 50% | 2005 | Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13
| First synthesis and evaluation of the inhibitory effects of aza analogues of TSAO on HIV-1 replication. |
AID977608 | Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |