Page last updated: 2024-12-06

tsao-t

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Cross-References

ID SourceID
PubMed CID65005
CHEMBL ID364136
CHEMBL ID1738875
MeSH IDM0202529

Synonyms (17)

Synonym
tsao-t
1-[(1r,3r,4r,5r)-6-amino-4-[tert-butyl(dimethyl)silyl]oxy-1-[[tert-butyl(dimethyl)silyl]oxymethyl]-8,8-dioxo-2,9-dioxa-8$l^{6}-thiaspiro[4.4]non-6-en-3-yl]-5-methyl-pyrimidine-2,4-dione
[1-[2',5'-bis-o-(tert-butyldimethylsilyl)-.beta.-d-ribofuranosyl]thymine]-(r)(ribo)-3'-spiro-5-(4-amino-1,2-oxathiole-2,2-dioxide)
141781-17-1
2,4(1h,3h)-pyrimidinedione, 1-(4-amino-9-(((1,1-dimethylethyl)dimethylsilyl)oxy)-6-((((1,1-dimethylethyl)dimethylsilyl)oxy)methyl)-1,7-dioxa-2-thiaspiro(4,4)non-3-en-8-yl)-5-methyl-, s,s-dioxide. (5r-(5alpha,6beta,8beta,9alpha))-
1-[(5r,6r,8r,9r)-4-amino-9-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dioxo-1,7-dioxa-2lambda*6*-thia-spiro[4.4]non-3-en-8-yl]-5-methyl-1h-pyrimidine-2,4-dione
chembl364136
[2'',5''-bis-o-(tert-butyldimethylsilyl)-b-d-ribofuranosyl]-3''-spiro-5''''-(4''''-amino-1'''',2''''-oxathiole-2'''',2''''-dioxide)thymine
[2'',5''-bis-o-(tert-butyldimethylsilyl)-beta-d-ribofuranosyl]-3''-spiro-5''''-(4''''-amino-1'', 2''-oxathiole-2'',2''-dioxide)thymine
bdbm50169035
CHEMBL1738875
wf66y930kh ,
unii-wf66y930kh
2,4(1h,3h)-pyrimidinedione, 1-((5r,6r,8r,9r)-4-amino-9-(((1,1-dimethylethyl)dimethylsilyl)oxy)-6-((((1,1-dimethylethyl)dimethylsilyl)oxy)methyl)-2,2-dioxido-1,7-dioxa-2-thiaspiro(4.4)non-3-en-8-yl)-5-methyl-
3QO9
Q27292602
1-[(5r,6r,8r,9r)-4-amino-9-[tert-butyl(dimethyl)silyl]oxy-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-2,2-dioxo-1,7-dioxa-2lambda6-thiaspiro[4.4]non-3-en-8-yl]-5-methylpyrimidine-2,4-dione
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Reverse transcriptase/ ribonuclease HHuman immunodeficiency virus type 1 BH10IC50 (µMol)1.20001.20001.20001.2000AID977608
Chain B, p51 RTHuman immunodeficiency virus type 1 BH10IC50 (µMol)1.20001.20001.20001.2000AID977608
Reverse transcriptase/RNaseH Human immunodeficiency virus 1IC50 (µMol)2.96670.00011.076810.0000AID268623; AID268624; AID593599
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (61)

Assay IDTitleYearJournalArticle
AID593504Antiviral activity against wild type HIV1 3B infected in human CEM cells assessed as inhibition of syncytia formation2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
AID593508Antiviral activity against HIV1 3B harboring reverse transcriptase E138K mutant infected in human CEM cells assessed as inhibition of syncytia formation2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
AID593505Antiviral activity against HIV1 3B harboring reverse transcriptase K103N mutant infected in human CEM cells assessed as inhibition of syncytia formation2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
AID593602Inhibition of HIV-1 reverse transcriptase K1001E and E138K mutant-mediated polymerization reaction after 30 mins2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
AID619908Antiviral activity against HIV1 harboring reverse transcriptase E138K mutant infected in human CEM cells assessed as inhibition of virus-induced cytopathicity after 4 days2011European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
Synthesis and in vitro activity of novel N-3 acylated TSAO-T compounds against HIV-1 and HCV.
AID593702Ratio of IC50 for HIV-1 reverse transcriptase K1001E and E138K mutant to IC50 for HIV-1 wild type reverse transcriptase2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
AID593698Ratio of EC50 for HIV1 3B harboring reverse transcriptase Y181I mutant to EC50 for wild type HIV1 3B2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
AID253508Concentration of compound inhibiting Lys103-Asn mutant HIV-1(IIIB) induced cytopathicity in CEM cell culture by 50%2005Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13
First synthesis and evaluation of the inhibitory effects of aza analogues of TSAO on HIV-1 replication.
AID593608Ratio of EC50 for HIV1 3B harboring reverse transcriptase N136A/Q/K mutant to EC50 for wild type HIV1 3B2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
AID593701Ratio of EC50 for HIV1 3B harboring reverse transcriptase G190E mutant to EC50 for wild type HIV1 3B2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
AID593612Ratio of EC50 for HIV1 3B harboring reverse transcriptase Y181C mutant to EC50 for wild type HIV1 3B2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
AID322454Antiviral activity against HIV1 3B in CEM cells assessed as inhibition of viral replication2008Bioorganic & medicinal chemistry letters, Apr-01, Volume: 18, Issue:7
Synthesis, anti-HIV-1 activity, and modeling studies of N-3 Boc TSAO compound.
AID593603Antiviral activity against wild type HIV1 infected in human CEM cells assessed as inhibition of syncytia formation2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
AID593611Ratio of EC50 for HIV1 3B harboring reverse transcriptase V179N mutant to EC50 for wild type HIV1 3B2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
AID245976Concentration of compound required to reduce by 50% the number of viable cells in mock infected MT-4 cell cultures2005Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13
First synthesis and evaluation of the inhibitory effects of aza analogues of TSAO on HIV-1 replication.
AID593503Antiviral activity against HIV1 3B harboring reverse transcriptase L100I mutant infected in human CEM cells assessed as inhibition of syncytia formation2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
AID246287Concentration of compound required to inhibit HIV-1(IIIB) induced cytopathicity in CEM cell culture by 50%2005Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13
First synthesis and evaluation of the inhibitory effects of aza analogues of TSAO on HIV-1 replication.
AID619903Antiviral activity against HIV1 3B infected in human CEM cells assessed as inhibition of virus-induced cytopathicity after 4 days2011European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
Synthesis and in vitro activity of novel N-3 acylated TSAO-T compounds against HIV-1 and HCV.
AID593599Inhibition of wild type HIV-1 reverse transcriptase-mediated polymerization reaction after 30 mins2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
AID268624Inhibition of HIV1 reverse transcriptase RNA-dependent DNA polymerase activity2006Journal of medicinal chemistry, Aug-10, Volume: 49, Issue:16
Structure-activity relationships of [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5' '-(4' '-amino-1' ',2' '-oxathiole-2' ',2' '-dioxide)thymine derivatives as inhibitors of HIV-1 reverse transcriptase dimerization.
AID593610Ratio of EC50 for HIV1 3B harboring reverse transcriptase E138D mutant to EC50 for wild type HIV1 3B2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
AID593509Antiviral activity against HIV1 3B harboring reverse transcriptase E138D mutant infected in human CEM cells assessed as inhibition of syncytia formation2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
AID593594Antiviral activity against HIV1 3B harboring reverse transcriptase Y181C mutant infected in human CEM cells assessed as inhibition of syncytia formation2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
AID593596Antiviral activity against HIV1 3B harboring reverse transcriptase Y188H mutant infected in human CEM cells assessed as inhibition of syncytia formation2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
AID619904Antiviral activity against HIV2 ROD infected in human CEM cells assessed as inhibition of virus-induced cytopathicity after 4 days2011European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
Synthesis and in vitro activity of novel N-3 acylated TSAO-T compounds against HIV-1 and HCV.
AID593598Antiviral activity against HIV1 3B harboring reverse transcriptase G190E mutant infected in human CEM cells assessed as inhibition of syncytia formation2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
AID619906Antiviral activity against HCV2a JFH1 infected in human Huh7 cells assessed as inhibition of viral replication after 72 hrs by luciferase reporter gene assay2011European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
Synthesis and in vitro activity of novel N-3 acylated TSAO-T compounds against HIV-1 and HCV.
AID593506Antiviral activity against HIV1 3B harboring reverse transcriptase V106A mutant infected in human CEM cells assessed as inhibition of syncytia formation2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
AID327202Antiviral activity against HIV2 ROD in CEM cells assessed as inhibition of virus-induced cytopathogenicity after 4 days2008Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8
Synthesis and anti-HIV1 biological activity of novel 5''-ATSAO compounds.
AID619905Cytotoxicity against human CEM cells after 4 days2011European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
Synthesis and in vitro activity of novel N-3 acylated TSAO-T compounds against HIV-1 and HCV.
AID81255Concentration required to inhibit HIV-1 induced cytopathicity in human MT-4 lymphocyte cells.1992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
3'-Spiro nucleosides, a new class of specific human immunodeficiency virus type 1 inhibitors: synthesis and antiviral activity of [2'-5'-bis-O-(tert-butyldimethylsilyl)-beta-D-xylo- and -ribofuranose]-3'-spiro-5"-[4"-amino-1",2"-oxathiole 2",2"-dioxide] (
AID619907Cytotoxicity against human HuH7 cells after 72 hrs2011European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
Synthesis and in vitro activity of novel N-3 acylated TSAO-T compounds against HIV-1 and HCV.
AID253510Concentration of compound inhibiting Tyr181- Cys mutant HIV-1(IIIB) induced cytopathicity in CEM cell culture by 50%2005Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13
First synthesis and evaluation of the inhibitory effects of aza analogues of TSAO on HIV-1 replication.
AID593507Antiviral activity against HIV1 3B harboring reverse transcriptase N136A/Q/K mutant infected in human CEM cells assessed as inhibition of syncytia formation2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
AID106589Concentration required to reduce human MT-4 cell viability by 50%.1992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
3'-Spiro nucleosides, a new class of specific human immunodeficiency virus type 1 inhibitors: synthesis and antiviral activity of [2'-5'-bis-O-(tert-butyldimethylsilyl)-beta-D-xylo- and -ribofuranose]-3'-spiro-5"-[4"-amino-1",2"-oxathiole 2",2"-dioxide] (
AID268626Inhibition of MT4 cell viability2006Journal of medicinal chemistry, Aug-10, Volume: 49, Issue:16
Structure-activity relationships of [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5' '-(4' '-amino-1' ',2' '-oxathiole-2' ',2' '-dioxide)thymine derivatives as inhibitors of HIV-1 reverse transcriptase dimerization.
AID322455Antiviral activity against HIV2 ROD in CEM cells assessed as inhibition of viral replication2008Bioorganic & medicinal chemistry letters, Apr-01, Volume: 18, Issue:7
Synthesis, anti-HIV-1 activity, and modeling studies of N-3 Boc TSAO compound.
AID593595Antiviral activity against HIV1 3B harboring reverse transcriptase Y181I mutant infected in human CEM cells assessed as inhibition of syncytia formation2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
AID593601Inhibition of HIV-1 reverse transcriptase E138K mutant-mediated polymerization reaction after 30 mins2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
AID245974Concentration of compound required to reduce by 50% the number of viable cells in mock infected CEM cell cultures2005Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13
First synthesis and evaluation of the inhibitory effects of aza analogues of TSAO on HIV-1 replication.
AID593609Ratio of EC50 for HIV1 3B harboring reverse transcriptase E138K mutant to EC50 for wild type HIV1 3B2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
AID327203Cytotoxicity against mock-infected human CEM cells assessed as reduction of cell viability after 4 days2008Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8
Synthesis and anti-HIV1 biological activity of novel 5''-ATSAO compounds.
AID268625Antiviral activity against HIV1 in MT4 cells2006Journal of medicinal chemistry, Aug-10, Volume: 49, Issue:16
Structure-activity relationships of [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5' '-(4' '-amino-1' ',2' '-oxathiole-2' ',2' '-dioxide)thymine derivatives as inhibitors of HIV-1 reverse transcriptase dimerization.
AID268623Inhibition of FLAG-p66/HIS-p51-mediated HIV1 reverse transcriptase dimerization2006Journal of medicinal chemistry, Aug-10, Volume: 49, Issue:16
Structure-activity relationships of [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5' '-(4' '-amino-1' ',2' '-oxathiole-2' ',2' '-dioxide)thymine derivatives as inhibitors of HIV-1 reverse transcriptase dimerization.
AID593606Ratio of EC50 for HIV1 3B harboring reverse transcriptase K103N mutant to EC50 for wild type HIV1 3B2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
AID322456Cytotoxicity against human CEM cells2008Bioorganic & medicinal chemistry letters, Apr-01, Volume: 18, Issue:7
Synthesis, anti-HIV-1 activity, and modeling studies of N-3 Boc TSAO compound.
AID246294Concentration of compound required to inhibit HIV-1(IIIB) induced cytopathicity in MT-4 cell culture by 50%2005Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13
First synthesis and evaluation of the inhibitory effects of aza analogues of TSAO on HIV-1 replication.
AID246295Concentration of compound required to inhibit HIV-2 (ROD) induced cytopathicity in MT-4 cell culture by 50%2005Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13
First synthesis and evaluation of the inhibitory effects of aza analogues of TSAO on HIV-1 replication.
AID327201Antiviral activity against HIV1 3B in CEM cells assessed as inhibition of virus-induced cytopathogenicity after 4 days2008Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8
Synthesis and anti-HIV1 biological activity of novel 5''-ATSAO compounds.
AID593600Inhibition of HIV-1 reverse transcriptase K101E mutant-mediated polymerization reaction after 30 mins2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
AID593699Ratio of EC50 for HIV1 3B harboring reverse transcriptase Y188H mutant to EC50 for wild type HIV1 3B2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
AID593510Antiviral activity against HIV1 3B harboring reverse transcriptase V179N mutant infected in human CEM cells assessed as inhibition of syncytia formation2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
AID235889Ratio of effective concentration to that of cytotoxic concentration against HIV-1 induced cytopathogenicity in MT-4 cells1992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
3'-Spiro nucleosides, a new class of specific human immunodeficiency virus type 1 inhibitors: synthesis and antiviral activity of [2'-5'-bis-O-(tert-butyldimethylsilyl)-beta-D-xylo- and -ribofuranose]-3'-spiro-5"-[4"-amino-1",2"-oxathiole 2",2"-dioxide] (
AID593700Ratio of EC50 for HIV1 3B harboring reverse transcriptase Y188L mutant to EC50 for wild type HIV1 3B2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
AID246288Concentration of compound required to inhibit HIV-2 (ROD) induced cytopathicity in CEM cell culture by 50%2005Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13
First synthesis and evaluation of the inhibitory effects of aza analogues of TSAO on HIV-1 replication.
AID593604Antiviral activity against wild type HIV2 infected in human CEM cells assessed as inhibition of syncytia formation2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
AID593597Antiviral activity against HIV1 3B harboring reverse transcriptase Y188L mutant infected in human CEM cells assessed as inhibition of syncytia formation2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
AID593607Ratio of EC50 for HIV1 3B harboring reverse transcriptase V106A mutant to EC50 for wild type HIV1 3B2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
AID593605Ratio of EC50 for HIV1 3B harboring reverse transcriptase L100I mutant to EC50 for wild type HIV1 3B2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
AID253507Concentration of compound inhibiting Glu138-Lys mutant HIV-1(IIIB) induced cytopathicity in CEM cell culture by 50%2005Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13
First synthesis and evaluation of the inhibitory effects of aza analogues of TSAO on HIV-1 replication.
AID977608Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB2011Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (45)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's24 (53.33)18.2507
2000's19 (42.22)29.6817
2010's2 (4.44)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 28.91

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index28.91 (24.57)
Research Supply Index3.91 (2.92)
Research Growth Index4.19 (4.65)
Search Engine Demand Index34.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (28.91)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews4 (8.16%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other45 (91.84%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]