ribavirin 5'-diphosphate profile

Ribavirin 5'-diphosphate is a nucleotide analog that inhibits the activity of the viral enzyme inosine monophosphate dehydrogenase (IMPDH). IMPDH is responsible for the synthesis of guanine nucleotides, which are essential for viral replication. By inhibiting IMPDH, ribavirin 5'-diphosphate reduces the production of guanine nucleotides, thereby inhibiting viral replication. Ribavirin 5'-diphosphate has been shown to be effective against a variety of viruses, including hepatitis C virus (HCV), respiratory syncytial virus (RSV), and influenza virus. The compound has also been studied for its potential use in the treatment of cancer. Ribavirin 5'-diphosphate is synthesized by phosphorylation of ribavirin, a nucleoside analog that is also used as an antiviral drug. The synthesis of ribavirin 5'-diphosphate involves a multi-step process that utilizes enzymes and chemical reagents to convert ribavirin to its diphosphate form. The compound is studied because of its potential to inhibit viral replication and its possible use in the treatment of cancer. Ribavirin 5'-diphosphate is an important compound because it may provide new avenues for the development of antiviral and anticancer therapies.'

ribavirin-5'-phosphate: RN given refers to 5'-phosphate cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ribavirin 5'-monophosphate : A 1-ribosyltriazole that is ribavirin in which the hydroxy group at the 5'-position is replaced by a phosphonooxy group. It is the active metabolite of the antiviral agent ribavirin. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ribavirin 5'-diphosphate : A 1-ribosyltriazole that is ribavirin in which the hydroxy group at the 5'-position is replaced by a diphosphate group. It is the metabolite of the antiviral agent ribavirin. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	100252
CHEMBL ID	1235764
CHEBI ID	45490
SCHEMBL ID	10882076
MeSH ID	M0157239
PubMed CID	124970
CHEMBL ID	3306225
CHEBI ID	180481
MeSH ID	M0157239

Synonym
CHEMBL1235764
1h-1,2,4-triazole-3-carboxamide, 1-(5-o-phosphono-.beta.-d-ribofuranosyl)-
[(2r,3s,4r,5r)-5-(3-carbamoyl-1,2,4-triazol-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate
icn 3847
nsc274937
ribavirin-5'-monophosphate
ribavirin 5'-p
40925-28-8
RVP ,
ribavirin monophosphate
nsc-274937
1h-1,2,4-triazole-3-carboxamide, 1-(5-o-phosphono-beta-d-ribofuranosyl)- (9ci)
ribavirin-5'-phosphate
1beta-d-ribofuranosyl-1,2,4-triazole-3-carboxamide-5'-phosphate
1-(5-o-phosphono-beta-d-ribofuranosyl)-1h-1,2,4-triazole-3-carboxamide
1h-1,2,4-triazole-3-carboxamide, 1-(5-o-phosphono-beta-d-ribofuranosyl)-
virazole 5'-phosphate
ribavirin 5'-monophosphate
ribavirin 5'-phosphate
1ME7
1ME8
nsc 274937
unii-o9fvv27p11
o9fvv27p11 ,
1-.beta.-d-ribofuranosyl-1,2,4-triazole-3-carboxamide-5'-phosphate
SCHEMBL10882076
DTXSID20193928
DB14663
Q27285517
ribavirin-mp
CHEBI:45490
rbv-mp
ribavirin-dp
63142-70-1
CHEBI:180481
ribavirin diphosphate
1-{5-o-[hydroxy(phosphonooxy)phosphoryl]-beta-d-ribofuranosyl}-1h-1,2,4-triazole-3-carboxamide
[5-(3-carbamoyl(1,2,4-triazolyl))-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
[(2r,3s,4r,5r)-5-(3-carbamoyl-1,2,4-triazol-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate
rdp
ribavirin 5'-diphosphate
[(2r,3s,4r,5r)-5-(3-carbamoyl-1,2,4-triazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphono hydrogen phosphate
1h-1,2,4-triazole-3-carboxamide, 1-(5-o-(hydroxy(phosphonooxy)phosphinyl)-beta-d-ribofuranosyl)-
ribavirin 5'-diphosphate lithium salt
CHEMBL3306225
DTXSID00212489

Role	Description
human blood serum metabolite	Any metabolite (endogenous or exogenous) found in human blood serum samples.
drug metabolite	null
antiviral agent	A substance that destroys or inhibits replication of viruses.
EC 1.1.1.205 (IMP dehydrogenase) inhibitor	An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of IMP dehydrogenase (EC 1.1.1.205), so blocking de novo biosynthesis of purine nucleotides.
antiviral agent	A substance that destroys or inhibits replication of viruses.
drug metabolite	null
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
1-ribosyltriazole	A 1-glycosyltriazole in which the glycosyl residue is specified as ribosyl.
ribose monophosphate
aromatic amide	An amide in which the amide linkage is bonded directly to an aromatic system.
monocarboxylic acid amide	A carboxamide derived from a monocarboxylic acid.
primary carboxamide	A carboxamide resulting from the formal condensation of a carboxylic acid with ammonia; formula RC(=O)NH2.
1-ribosyltriazole	A 1-glycosyltriazole in which the glycosyl residue is specified as ribosyl.
aromatic amide	An amide in which the amide linkage is bonded directly to an aromatic system.
monocarboxylic acid amide	A carboxamide derived from a monocarboxylic acid.
primary carboxamide	A carboxamide resulting from the formal condensation of a carboxylic acid with ammonia; formula RC(=O)NH2.
ribose diphosphate
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, Inosine-5'-monophosphate Dehydrogenase	Tritrichomonas suis	Ki	0.0650	0.0650	0.0650	0.0650	AID977610
Chain A, Inosine-5'-monophosphate Dehydrogenase	Tritrichomonas suis	Ki	0.0650	0.0650	0.0650	0.0650	AID977610
Genome polyprotein		IC50 (µMol)	250.0000	0.7000	1.9567	3.8000	AID240983
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (28)

Assay ID	Title	Year	Journal	Article
AID977610	Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB	2002	The Journal of biological chemistry, Dec-27, Volume: 277, Issue:52	Crystal structure of Tritrichomonas foetus inosine monophosphate dehydrogenase in complex with the inhibitor ribavirin monophosphate reveals a catalysis-dependent ion-binding site.
AID1811	Experimentally measured binding affinity data derived from PDB	2002	The Journal of biological chemistry, Dec-27, Volume: 277, Issue:52	Crystal structure of Tritrichomonas foetus inosine monophosphate dehydrogenase in complex with the inhibitor ribavirin monophosphate reveals a catalysis-dependent ion-binding site.
AID578590	Inhibition of GATA4-DNA interaction in HEK293 nuclear extract at 150 uM after 15 mins by EMSA assay	2011	Bioorganic & medicinal chemistry, Mar-01, Volume: 19, Issue:5	Identification of new GATA4-small molecule inhibitors by structure-based virtual screening.
AID578592	Inhibition of GATA4- DNA interaction in mouse C2C12 cells at 100 uM after 24 hrs by EMSA assay	2011	Bioorganic & medicinal chemistry, Mar-01, Volume: 19, Issue:5	Identification of new GATA4-small molecule inhibitors by structure-based virtual screening.
AID1133197	Inhibition of Escherichia coli IMP cyclohydrolase (unknown origin) assessed as ratio of compound concentration for 50% inhibition of enzyme activity to 1.7 to 3 x 10'-5 M of substrate concentration	1978	Journal of medicinal chemistry, Dec, Volume: 21, Issue:12	Synthesis and antiviral and enzymatic studies of certain 3-deazaguanines and their imidazolecarboxamide precursors.
AID578597	Inhibition of GATA4-DNA interaction in HEK293 nuclear extract at 50 to 150 uM after 15 mins by EMSA assay	2011	Bioorganic & medicinal chemistry, Mar-01, Volume: 19, Issue:5	Identification of new GATA4-small molecule inhibitors by structure-based virtual screening.
AID578595	Lipophilicity, log P of compound	2011	Bioorganic & medicinal chemistry, Mar-01, Volume: 19, Issue:5	Identification of new GATA4-small molecule inhibitors by structure-based virtual screening.
AID578589	Inhibition of GATA4-DNA interaction in HEK293 nuclear extract at 100 uM after 15 mins by EMSA assay	2011	Bioorganic & medicinal chemistry, Mar-01, Volume: 19, Issue:5	Identification of new GATA4-small molecule inhibitors by structure-based virtual screening.
AID1133195	Inhibition of Escherichia coli IMP dehydrogenase assessed as ratio of compound concentration for 50% inhibition of enzyme activity to 1.7 to 3 x 10'-5 M of substrate concentration	1978	Journal of medicinal chemistry, Dec, Volume: 21, Issue:12	Synthesis and antiviral and enzymatic studies of certain 3-deazaguanines and their imidazolecarboxamide precursors.
AID92599	Noncompetitive inhibitory activity against Inosine-5'-monophosphate dehydrogenase using NAD as viable substrate	1985	Journal of medicinal chemistry, Jan, Volume: 28, Issue:1	Ribavirin, tiazofurin, and selenazofurin: mononucleotides and nicotinamide adenine dinucleotide analogues. Synthesis, structure, and interactions with IMP dehydrogenase.
AID578600	Cytotoxicity in mouse C2C12 cells assessed as effect on cell proliferation upto 150 uM	2011	Bioorganic & medicinal chemistry, Mar-01, Volume: 19, Issue:5	Identification of new GATA4-small molecule inhibitors by structure-based virtual screening.
AID578593	Inhibition of GATA4 in mouse C2C12 cells assessed as myoblast differentiation to myotubes at 100 uM after 48 hrs by immunofluorescence assay in presence of 0.5% FBS relative to control	2011	Bioorganic & medicinal chemistry, Mar-01, Volume: 19, Issue:5	Identification of new GATA4-small molecule inhibitors by structure-based virtual screening.
AID578594	Inhibition of GATA4 in mouse C2C12 cells assessed as myoblast differentiation to myotubes at 100 uM after 48 hrs by immunofluorescence assay in presence of 20 % FBS relative to control	2011	Bioorganic & medicinal chemistry, Mar-01, Volume: 19, Issue:5	Identification of new GATA4-small molecule inhibitors by structure-based virtual screening.
AID578603	Cytotoxicity in human HEK293 cells assessed as cell death upto 150 uM	2011	Bioorganic & medicinal chemistry, Mar-01, Volume: 19, Issue:5	Identification of new GATA4-small molecule inhibitors by structure-based virtual screening.
AID92590	Competitive Inhibitory activity against Inosine-5'-monophosphate dehydrogenase using IMP as viable substrate	1985	Journal of medicinal chemistry, Jan, Volume: 28, Issue:1	Ribavirin, tiazofurin, and selenazofurin: mononucleotides and nicotinamide adenine dinucleotide analogues. Synthesis, structure, and interactions with IMP dehydrogenase.
AID578602	Cytotoxicity in mouse C2C12 cells assessed as cell death upto 150 uM	2011	Bioorganic & medicinal chemistry, Mar-01, Volume: 19, Issue:5	Identification of new GATA4-small molecule inhibitors by structure-based virtual screening.
AID578599	Cytotoxicity in human HEK293 cells assessed as effect on cell proliferation upto 150 uM	2011	Bioorganic & medicinal chemistry, Mar-01, Volume: 19, Issue:5	Identification of new GATA4-small molecule inhibitors by structure-based virtual screening.
AID578605	Effect on NFATc1 in HEK293 nuclear extract at 50 uM after 15 mins by EMSA assay	2011	Bioorganic & medicinal chemistry, Mar-01, Volume: 19, Issue:5	Identification of new GATA4-small molecule inhibitors by structure-based virtual screening.
AID1123337	Inhibition of rat spleen IMP dehydrogenase using NAD and IMP up to 1 hr	1979	Journal of medicinal chemistry, Jun, Volume: 22, Issue:6	Studies on the mechanism of antiviral action of 1-(beta-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide (ribavirin).
AID578591	Inhibition of GATA4- mediated BNP promoter activation in HeLa cells at 100 uM after 24 hrs by luciferase reporter gene assay	2011	Bioorganic & medicinal chemistry, Mar-01, Volume: 19, Issue:5	Identification of new GATA4-small molecule inhibitors by structure-based virtual screening.
AID578588	Inhibition of GATA4-DNA interaction in HEK293 nuclear extract at 50 uM after 15 mins by EMSA assay	2011	Bioorganic & medicinal chemistry, Mar-01, Volume: 19, Issue:5	Identification of new GATA4-small molecule inhibitors by structure-based virtual screening.
AID578601	Cytotoxicity in human HeLa cells assessed as cell death upto 150 uM	2011	Bioorganic & medicinal chemistry, Mar-01, Volume: 19, Issue:5	Identification of new GATA4-small molecule inhibitors by structure-based virtual screening.
AID578598	Cytotoxicity in human HeLa cells assessed as effect on cell proliferation upto 150 uM	2011	Bioorganic & medicinal chemistry, Mar-01, Volume: 19, Issue:5	Identification of new GATA4-small molecule inhibitors by structure-based virtual screening.
AID578604	Effect on Tbx5 in HEK293 nuclear extract at 50 uM after 15 mins by EMSA assay	2011	Bioorganic & medicinal chemistry, Mar-01, Volume: 19, Issue:5	Identification of new GATA4-small molecule inhibitors by structure-based virtual screening.
AID578596	Drug uptake in human HeLa cells after 24 hrs	2011	Bioorganic & medicinal chemistry, Mar-01, Volume: 19, Issue:5	Identification of new GATA4-small molecule inhibitors by structure-based virtual screening.
AID1133196	Inhibition of Escherichia coli adenylosuccinate synthetase assessed as ratio of compound concentration for 50% inhibition of enzyme activity to 1.7 to 3 x 10'-5 M of substrate concentration	1978	Journal of medicinal chemistry, Dec, Volume: 21, Issue:12	Synthesis and antiviral and enzymatic studies of certain 3-deazaguanines and their imidazolecarboxamide precursors.
AID152713	Cytotoxicity against P388 cells in culture	1985	Journal of medicinal chemistry, Jan, Volume: 28, Issue:1	Ribavirin, tiazofurin, and selenazofurin: mononucleotides and nicotinamide adenine dinucleotide analogues. Synthesis, structure, and interactions with IMP dehydrogenase.
AID240983	Inhibitory concentration against hepatitis C virus helicase	2005	Journal of medicinal chemistry, Jan-13, Volume: 48, Issue:1	Control of hepatitis C: a medicinal chemistry perspective.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	9 (52.94)	18.7374
1990's	1 (5.88)	18.2507
2000's	3 (17.65)	29.6817
2010's	4 (23.53)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Reviews	1 (16.67%)	6.00%
Case Studies	0 (0.00%)	4.05%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Observational	0 (0.00%)	0.25%
Other	14 (100.00%)	84.16%
Other	5 (83.33%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
xanthine 7H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-7 is protonated.. 9H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-9 is protonated.	1.97	1	xanthine	Saccharomyces cerevisiae metabolite
uridine [no description available]	2.07	1	uridines	drug metabolite; fundamental metabolite; human metabolite
uridine monophosphate Uridine Monophosphate: 5'-Uridylic acid. A uracil nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position.. uridine 5'-monophosphate : A pyrimidine ribonucleoside 5'-monophosphate having uracil as the nucleobase.	2.07	1	pyrimidine ribonucleoside 5'-monophosphate; uridine 5'-phosphate	Escherichia coli metabolite; human metabolite; mouse metabolite
uridine diphosphate Uridine Diphosphate: A uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety.	2.07	1	pyrimidine ribonucleoside 5'-diphosphate; uridine 5'-phosphate	Escherichia coli metabolite; mouse metabolite
adenosine monophosphate Adenosine Monophosphate: Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.	2.07	1	adenosine 5'-phosphate; purine ribonucleoside 5'-monophosphate	adenosine A1 receptor agonist; cofactor; EC 3.1.3.1 (alkaline phosphatase) inhibitor; EC 3.1.3.11 (fructose-bisphosphatase) inhibitor; fundamental metabolite; micronutrient; nutraceutical
3,4-dihydropyran [no description available]	1.95	1
ribavirin Rebetron: Rebetron is tradename	3.68	10	1-ribosyltriazole; aromatic amide; monocarboxylic acid amide; primary carboxamide	anticoronaviral agent; antiinfective agent; antimetabolite; antiviral agent; EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
3-deazaguanine 3-deazaguanine: structure	1.95	1
adenosine quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit	1.95	1	adenosines; purines D-ribonucleoside	analgesic; anti-arrhythmia drug; fundamental metabolite; human metabolite; vasodilator agent
aica ribonucleotide AICA ribonucleotide: purine precursor that has antineoplastic activity. AICA ribonucleotide : A 1-(phosphoribosyl)imidazolecarboxamide that is acadesine in which the hydroxy group at the 5' position has been converted to its monophosphate derivative.	1.96	1	1-(phosphoribosyl)imidazolecarboxamide; aminoimidazole	cardiovascular drug; Escherichia coli metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite
1,2,4-triazole-3-carboxamide 1,2,4-triazole-3-carboxamide : A member of the class of triazoles that is 1H-1,2,4-triazole substituted by an aminocarbonyl group at position 3. It is the major catabolite and aglycon of ribavirin.	1.95	1	aromatic amide; monocarboxylic acid amide; primary carboxamide; triazoles	drug metabolite; human urinary metabolite
triazoles Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.	1.95	1	1,2,3-triazole
xanthosine 5'-triphosphate xanthosine 5'-phosphate : xanthosine phosphate compounds having phosphate groups at position 5'.. 5'-xanthylic acid : A purine ribonucleoside 5'-monophosphate having xanthine as the nucleobase.	1.97	1	purine ribonucleoside 5'-monophosphate; xanthosine 5'-phosphate	Escherichia coli metabolite; metabolite; mouse metabolite
thiazole-4-carboxamide adenine dinucleotide thiazole-4-carboxamide adenine dinucleotide: structure given in first source	2.37	2
mizoribine [no description available]	2.08	1	imidazoles	anticoronaviral agent
ribavirin 5'-triphosphate ribavirin 5'-triphosphate: structure given in first source. ribavirin 5'-triphosphate : A 1-ribosyltriazole that is ribavirin in which the hydroxy group at the 5'-position is replaced by a triphosphate group. It is the active metabolite of the antiviral agent ribavirin.	3.1	5	1-ribosyltriazole; aromatic amide; monocarboxylic acid amide; primary carboxamide; ribose triphosphate	antiviral agent; drug metabolite; EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitor; eukaryotic initiation factor 4F inhibitor; human blood serum metabolite
3-deazaguanosine 3-deazaguanosine: structure	1.95	1
mycophenolic acid Mycophenolic Acid: Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION.. mycophenolate : A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of mycophenolic acid.. mycophenolic acid : A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases.	2.08	1	2-benzofurans; gamma-lactone; monocarboxylic acid; phenols	anticoronaviral agent; antimicrobial agent; antineoplastic agent; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; environmental contaminant; immunosuppressive agent; mycotoxin; Penicillium metabolite; xenobiotic
nad NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.	2.41	2	organophosphate oxoanion	cofactor; human metabolite; hydrogen acceptor; Saccharomyces cerevisiae metabolite
guanosine monophosphate Guanosine Monophosphate: A guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.. guanosine 5'-monophosphate : A purine ribonucleoside 5'-monophosphate having guanine as the nucleobase.	1.97	1	guanosine 5'-phosphate; purine ribonucleoside 5'-monophosphate	biomarker; Escherichia coli metabolite; metabolite; mouse metabolite
inosinic acid Inosine Monophosphate: Inosine 5'-Monophosphate. A purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety.	2.41	2	inosine phosphate; purine ribonucleoside 5'-monophosphate	Escherichia coli metabolite; human metabolite; mouse metabolite
4,5,6,7-tetrabromo-2-azabenzimidazole 4,5,6,7-tetrabromobenzotriazole: a CK2 kinase inhibitor	3.12	1
patulin Patulin: 4-Hydroxy-4H-furo(3,2-c)pyran-2(6H)-one. A mycotoxin produced by several species of Aspergillus and Penicillium. It is found in unfermented apple and grape juice and field crops. It has antibiotic properties and has been shown to be carcinogenic and mutagenic and causes chromosome damage in biological systems.. patulin : A furopyran and lactone that is (2H-pyran-3(6H)-ylidene)acetic acid which is substituted by hydroxy groups at positions 2 and 4 and in which the hydroxy group at position 4 has condensed with the carboxy group to give the corresponding bicyclic lactone. A mycotoxin produced by several species of Aspergillus and Penicillium, it has antibiotic properties but has been shown to be carcinogenic and mutagenic.	3.12	1	furopyran; gamma-lactone; lactol	antimicrobial agent; Aspergillus metabolite; carcinogenic agent; mutagen; mycotoxin; Penicillium metabolite
trifluoperazine [no description available]	3.12	1	N-alkylpiperazine; N-methylpiperazine; organofluorine compound; phenothiazines	antiemetic; calmodulin antagonist; dopaminergic antagonist; EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor; EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor; phenothiazine antipsychotic drug
uridine [no description available]	2.07	1	uridines	drug metabolite; fundamental metabolite; human metabolite
uridine monophosphate Uridine Monophosphate: 5'-Uridylic acid. A uracil nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position.. uridine 5'-monophosphate : A pyrimidine ribonucleoside 5'-monophosphate having uracil as the nucleobase.	2.07	1	pyrimidine ribonucleoside 5'-monophosphate; uridine 5'-phosphate	Escherichia coli metabolite; human metabolite; mouse metabolite
uridine diphosphate Uridine Diphosphate: A uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety.	2.07	1	pyrimidine ribonucleoside 5'-diphosphate; uridine 5'-phosphate	Escherichia coli metabolite; mouse metabolite
adenosine monophosphate Adenosine Monophosphate: Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.	2.07	1	adenosine 5'-phosphate; purine ribonucleoside 5'-monophosphate	adenosine A1 receptor agonist; cofactor; EC 3.1.3.1 (alkaline phosphatase) inhibitor; EC 3.1.3.11 (fructose-bisphosphatase) inhibitor; fundamental metabolite; micronutrient; nutraceutical
michler's ketone [no description available]	3.12	1	benzophenones
neutral red base neutral red base : A member of the class of phenazines carrying methyl, amino and dimethylamino substituents at positions 2, 3 and 7 respectively. The free base of neutral red, which acts as a pH indicator, changing from red to yellow between pH 6.8 and 8.0.	3.12	1	aromatic amine; phenazines; primary amino compound; tertiary amino compound	acid-base indicator; dye; two-colour indicator
zidovudine Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.. zidovudine : A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.	1.97	1	azide; pyrimidine 2',3'-dideoxyribonucleoside	antimetabolite; antiviral drug; HIV-1 reverse transcriptase inhibitor
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	3.12	1	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
ribavirin Rebetron: Rebetron is tradename	3.09	5	1-ribosyltriazole; aromatic amide; monocarboxylic acid amide; primary carboxamide	anticoronaviral agent; antiinfective agent; antimetabolite; antiviral agent; EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
epirubicin Epirubicin: An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.	3.12	1	aminoglycoside; anthracycline antibiotic; anthracycline; deoxy hexoside; monosaccharide derivative; p-quinones; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	antimicrobial agent; antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
ribavirin 5'-triphosphate ribavirin 5'-triphosphate: structure given in first source. ribavirin 5'-triphosphate : A 1-ribosyltriazole that is ribavirin in which the hydroxy group at the 5'-position is replaced by a triphosphate group. It is the active metabolite of the antiviral agent ribavirin.	4.2	5	1-ribosyltriazole; aromatic amide; monocarboxylic acid amide; primary carboxamide; ribose triphosphate	antiviral agent; drug metabolite; EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitor; eukaryotic initiation factor 4F inhibitor; human blood serum metabolite
4-phenyl-4-oxo-2-hydroxybuten-2-oic acid 2,4-dioxo-4-phenylbutanoic acid: structure in first source	3.12	1
biln 2061 BILN 2061: a macrocyclic NS3 protease inhibitor and antiviral agent; structure in first source	3.12	1

Condition	Relationship Strength	Studies
Carcinoma, Ehrlich Tumor A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.	2.36	2
Infections, Orthomyxoviridae [description not available]	1.95	1
Orthomyxoviridae Infections Virus diseases caused by the ORTHOMYXOVIRIDAE.	1.95	1
Leukemia P388 An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.	1.96	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.78	3
Chronic Hepatitis C [description not available]	2.48	2
Hepatitis C, Chronic INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead to LIVER CIRRHOSIS.	2.48	2
Experimental Hepatoma [description not available]	2.37	2
Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted [description not available]	2.94	1
Hepatitis C INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.	2.94	1

ribavirin 5'-diphosphate

Description

Cross-References

Synonyms (46)

Roles (4)

Drug Classes (6)

Protein Targets (3)

Inhibition Measurements

Bioassays (28)

Research

Studies (17)

Market Indicators

Research Demand Index: 11.88

Study Types

ribavirin 5'-diphosphate

Description

Cross-References

Synonyms (46)

Roles (4)

Drug Classes (6)

Protein Targets (3)

Inhibition Measurements

Bioassays (28)

Research

Studies (17)

Market Indicators

Research Demand Index: 11.88

Study Types

Related Drugs (37)

Related Conditions (10)