Page last updated: 2024-09-27

Lymphangioleiomyomatosis

A disease characterized by the progressive invasion of SMOOTH MUSCLE CELLS into the LYMPHATIC VESSELS, and the BLOOD VESSELS. The majority of the cases occur in the LUNGS of women of child-bearing age, eventually blocking the flow of air, blood, and lymph. The common symptom is shortness of breath (DYSPNEA).

Synonyms(1)

Synonym
Lymphangioleiomyomatosis

Research Excerpts

Overview

ExcerptReference
"Pulmonary lymphangioleiomyomatosis is a rare and exclusively female disease which is oestrogen dependent and has a serious prognosis."( Bauters, C; Copin, MC; Desurmont, S; Dewailly, D; Tonnel, AB; Wallaert, B, 1996)
"Lymphangioleiomyomatosis is a rare lung disease of unknown aetiology that affects only women."( Bestry, I; Korzeniewska-Koseła, M; Kowalski, J; Kuś, J; Langfort, R; Maziarka, D; Słodkowska, J; Wesołowski, S, 2001)
"Lymphangioleiomyomatosis is a progressive interstitial lung disease that affects young women."( Contini, P; Foschini, MP; Pozzati, E; Schiavina, M; Zucchelli, M, 2007)
"The prevalence of lymphangioleiomyomatosis is probably underestimated based on its clinical latency and the absence of specific laboratory tests."( Hohman, DW; Noghrehkar, D; Ratnayake, S, 2008)
"Pulmonary lymphangioleiomyomatosis is a rare disease that generally progresses to respiratory failure."( Bando, T; Chen, F; Fujinaga, T; Kondo, N; Omasa, M; Sakai, H; Shoji, T, 2009)
"Lymphangioleiomyomatosis is a rare cause of pneumothorax in women."( Keane, MP; Kelly, E; McDonnell, TJ; Mhurchu, EN; Sukor, S; Tryfonopoulos, D, 2010)
"Lymphangioleiomyomatosis is a rare disease which results from a defect of TSC genes."( Jaguś, P; Mydłowski, T; Oniszh, K; Radzikowska, E; Szczepulska-Wójcik, E; Wiatr, E, 2013)
"Pulmonary lymphangioleiomyomatosis is an uncommon disease of unknown etiology characterized by the proliferation of abnormal smooth muscle cells in the lungs, leading to parenchymal destruction and progressive respiratory failure."( Adorno-Fontánez, E; Adorno-Fontánez, J; Fernández-Gonzales, R; Fernández-Medero, R; Nieves-Nieves, J; Valentín-Mendoza, S, 2013)
"Lymphangioleiomyomatosis is a rare, progressive cystic lung disorder characterised by dysregulated activation of mammalian target of rapamycin (mTOR) signalling."( Biswal, S; Cheng, Y; Cottin, V; Goldberg, HJ; Harari, S; Henske, EP; Khindri, S; Kovarik, JM; Ma, S; McCormack, FX; Peters, E; Rosas, IO, 2015)
"Lymphangioleiomyomatosis is a rare multisystem disease predominantly affecting women that can occur sporadically or in association with tuberous sclerosis."( Johnson, SR; Moss, J; Taveira-DaSilva, AM, 2016)
"Lymphangioleiomyomatosis is a rare lung disease caused by proliferation of abnormal smooth muscle-like cells and typically occurs in premenopausal women."( Akazawa, K; Arai, T; Hattori, N; Hayashida, M; Hirai, T; Hirose, M; Inoue, Y; Kitamura, N; Mishima, M; Moriyama, H; Nagai, K; Nakata, K; Seyama, K; Sugimoto, C; Suzuki, M; Takada, T; Tamada, T; Tanaka, T; Tazawa, R; Watanabe, K, 2017)
"Lymphangioleiomyomatosis is a rare progressive disease that causes cystic destruction of the lungs and is frequently associated with extrapulmonary tumor infiltration, typically of the kidney and liver."( Kazim, M; Mechel, E; Tooley, A; Tran, AQ, 2022)

Treatment

ExcerptReference
"Sirolimus, the standard treatment for lymphangioleiomyomatosis, stabilizes lung function, but all patients do not respond to or tolerate sirolimus."( Moss, J; Pacheco-Rodriguez, G; Steagall, WK; Stylianou, M, 2019)

Research

Studies (312)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's28 (8.97)12.5806
2000's78 (25.00)18.1394
2010's157 (50.32)28.8240
2020's49 (15.71)9.53
DrugIndicatedRelationship StrengthStudiesTrials
carbon monoxide0low70
histamine0low10
methanol0low10
diatrizoic acid0low10
aspirin0low10
azathioprine0low10
chloroquine0low10
fenthion0low10
hydrochlorothiazide0low10
iohexol0low10
pamidronate0low10
ritanserin0low10
prednisolone0low20
estrone0low10
methacholine chloride0low10
medroxyprogesterone acetate0low70
n-vinyl-2-pyrrolidinone0low20
pyrroles0low20
quinazolines0low20
indazoles0low10
evans blue0low10
medroxyprogesterone0low120
malondialdehyde0medium11
isodesmosine0low10
vancomycin0low10
megestrol0low10
xenon0low10
technetium 99m0low10
danazol0low10
ribavirin0low10
pirfenidone0low20
propiconazole0low10
buserelin0low10
simvastatin0medium41
itraconazole0low10
atorvastatin0low10
xenon radioisotopes0low10
triazoles0low10
fluorodeoxyglucose f180low20
clarithromycin0low10
fibrinogen0medium11
nomegestrol acetate0low10
fulvestrant0low10
tryptoline0low10
1,4,7-triazacyclononane-n,n',n''-triacetic acid0low10
technetium tc 99m pentetate0low10
angiotensin ii0low10
lapatinib0low10
trimethoprim, sulfamethoxazole drug combination0low10
bortezomib0low10
glycogen0low10
elastin0low30
farnesol0low20
tacrolimus0low10
mycophenolic acid0low10
bromochloroacetic acid0low20
stilbenes0low20
picibanil0low30
leuprolide0low50
enclomiphene0low10
tamoxifen0low100
nadp0low10
osteoprotegerin0low10
dinoprostone0low20
lipoxin a40low10
pulmicort0low10
cyproterone0low10
goserelin0low20
lysophosphatidylcholines0low10
antimony0low10
cysteine0low10
s-trans,trans-farnesylthiosalicylic acid0low20
s-farnesylcysteine0low10
axitinib0low10
mart-1 antigen0low30
tofacitinib0low10
3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2h)-isoquinolinone0low10
trametinib0low10
losartan potassium0low10
desmosine0low10
hes1 protein, human0low10
angiotensinogen0low10
endothelin-10low10
sodium pertechnetate tc 99m0low20
olaparib0low10
trelstar0low20
piperidines0low20
interleukin-80low10
salicylates0low20
epidermal growth factor0low20
transforming growth factor beta0low20
cyclin d10low10
cyclosporine0low10
entecavir0low10
nu 10250low10
guanine0low10
sildenafil citrate0low10
nintedanib0low10
pyrimidinones0low10

Protein Targets (1,347)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Beta-lactamase 0202
Poly [ADP-ribose] polymerase 20101
Transient receptor potential cation channel subfamily M member 20101
Poly [ADP-ribose] polymerase 10426
Chain E, Purine nucleoside phosphorylase0101
Chain A, HADH2 protein100010
Chain B, HADH2 protein100010
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Chain A, Ferritin light chain9009
Thymidine kinase 0101
thioredoxin reductase9009
phosphopantetheinyl transferase8008
GLS protein8008
TDP1 protein320032
Smad37007
thyroid stimulating hormone receptor110011
EWS/FLI fusion protein140014
arylsulfatase A110011
euchromatic histone-lysine N-methyltransferase 2200020
activating transcription factor 6110011
Histone H2A.x110011
Bloom syndrome protein isoform 19009
hemoglobin subunit beta2002
atrial natriuretic peptide receptor 1 precursor1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
lamin isoform A-delta10150015
Solute carrier family 22 member 1 0003
ATP-binding cassette sub-family C member 3026026
Multidrug resistance-associated protein 4026027
Solute carrier family 22 member 60203
Bile salt export pump0202
Bile salt export pump032032
Purine nucleoside phosphorylase0303
Thymidine kinase, cytosolic0001
POU domain, class 2, transcription factor 20001
Cytochrome P450 2C9 0707
Cytochrome P450 2J20505
Disintegrin and metalloproteinase domain-containing protein 171001
Purine nucleoside phosphorylase0011
Solute carrier family 22 member 60002
Thymidine kinase 0101
Solute carrier family 22 member 80002
Canalicular multispecific organic anion transporter 1025025
Thymidine kinase0101
glp-1 receptor, partial100010
regulator of G-protein signaling 48008
estrogen-related nuclear receptor alpha310031
estrogen nuclear receptor alpha360036
NPYLR7B0011
thyroid stimulating hormone receptor120012
flap endonuclease 13003
peripheral myelin protein 22110011
Beta-2 adrenergic receptor0224
Beta-1 adrenergic receptor0224
60 kDa chaperonin0202
60 kDa heat shock protein, mitochondrial0303
Beta-3 adrenergic receptor0819
Delta-type opioid receptor0213
10 kDa heat shock protein, mitochondrial0303
Thiosulfate sulfurtransferase0303
Beta-2 adrenergic receptor 0013
60 kDa chaperonin 0303
10 kDa chaperonin 0303
Beta-2 adrenergic receptor0123
ATP-dependent phosphofructokinase6006
glucocerebrosidase4004
DNA polymerase kappa isoform 15005
histone acetyltransferase KAT2A isoform 14004
Atrial natriuretic peptide receptor 30101
Type-1A angiotensin II receptor 0314
Type-1 angiotensin II receptor0011
Type-1B angiotensin II receptor0404
Type-1 angiotensin II receptor0224
Type-2 angiotensin II receptor0303
Type-2 angiotensin II receptor0202
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE100010
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Chain A, Phospholipase A2 isoform 30011
Chain A, 2-oxoglutarate Oxygenase6006
GTP-binding protein (rab7)0022
ras protein, partial0022
interleukin 84004
AR protein360036
aldehyde dehydrogenase 1 family, member A19009
hypothetical protein, conserved1001
cytochrome P450 family 3 subfamily A polypeptide 4210021
glucocorticoid receptor [Homo sapiens]280028
retinoic acid nuclear receptor alpha variant 1260026
cytochrome P450 2D6100010
peroxisome proliferator-activated receptor delta180018
Rac1 protein0022
IDH1100010
cell division cycle 42 (GTP binding protein, 25kDa), partial0022
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 15005
DNA polymerase iota isoform a (long)110011
muscarinic acetylcholine receptor M15005
lethal factor (plasmid)5005
Prostaglandin-H2 D-isomerase0101
Prostaglandin G/H synthase 1 0202
Prostaglandin G/H synthase 2 0202
Epidermal growth factor receptor08715
Carbonic anhydrase 10709
Carbonic anhydrase 209012
Fatty acid-binding protein, liver0202
Integrin beta-33104
Myeloperoxidase0101
Prostaglandin G/H synthase 10314
Seed linoleate 13S-lipoxygenase-10202
Integrin alpha-IIb3104
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10607
Adenosine receptor A10203
Adenosine receptor A2a0102
Substance-P receptor0101
Prostaglandin G/H synthase 208514
Urotensin-2 receptor0202
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma7007
Ras-related protein Rab-2A0022
Gamma-aminobutyric acid receptor subunit alpha-1143017
Prostaglandin G/H synthase 20404
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200202
Solute carrier family 22 member 60202
Sigma non-opioid intracellular receptor 10617
Sigma non-opioid intracellular receptor 10011
Chain A, Cruzipain4004
RAR-related orphan receptor gamma260026
SMAD family member 2160016
SMAD family member 3160016
GLI family zinc finger 3280028
caspase 7, apoptosis-related cysteine protease7007
estrogen receptor 2 (ER beta)170017
nuclear receptor subfamily 1, group I, member 3250025
retinoid X nuclear receptor alpha220022
pregnane X nuclear receptor250025
peroxisome proliferator activated receptor gamma220022
vitamin D (1,25- dihydroxyvitamin D3) receptor150015
caspase-37007
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a250025
Caspase-74004
vitamin D3 receptor isoform VDRA8008
thyroid hormone receptor beta isoform a6006
caspase-34004
thyroid hormone receptor beta isoform 2270027
nuclear factor erythroid 2-related factor 2 isoform 1250025
geminin250025
Voltage-dependent calcium channel gamma-2 subunit210021
Solute carrier organic anion transporter family member 2B1 0001
3-hydroxy-3-methylglutaryl-coenzyme A reductase0404
Cellular tumor antigen p53240024
ATP-dependent translocase ABCB107412
Insulin receptor 0202
Glutamate receptor 2211022
Dipeptidyl peptidase 40101
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0202
Histone deacetylase 10404
Histone deacetylase 20404
Solute carrier organic anion transporter family member 1B30102
Histone deacetylase 60404
Broad substrate specificity ATP-binding cassette transporter ABCG20516
Solute carrier organic anion transporter family member 1B10506
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 20101
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 20101
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 20101
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 20101
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 20101
Leukotriene C4 synthase0044
Luciferase5005
acetylcholinesterase8008
PPM1D protein100010
progesterone receptor190019
farnesoid X nuclear receptor180018
G190019
aryl hydrocarbon receptor110011
histone deacetylase 9 isoform 33003
tyrosine-protein kinase Yes4004
Bone morphogenetic protein receptor type-1B0077
Cell division cycle 7-related protein kinase0055
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform0044
Serine/threonine-protein kinase PLK40279
Serine/threonine-protein kinase 250044
ATP-dependent RNA helicase DDX3X0077
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta0044
Pyridoxal kinase0077
Citron Rho-interacting kinase0077
Serine/threonine-protein kinase RIO30044
Dual specificity mitogen-activated protein kinase kinase 70145
Serine/threonine-protein kinase Chk10279
Inhibitor of nuclear factor kappa-B kinase subunit beta0044
Peripheral plasma membrane protein CASK0044
Aurora kinase A0077
Cyclin-G-associated kinase0077
Serine/threonine-protein kinase DCLK10044
Inhibitor of nuclear factor kappa-B kinase subunit alpha0044
Muscle, skeletal receptor tyrosine-protein kinase0044
Ephrin type-B receptor 60077
Peroxisomal acyl-coenzyme A oxidase 30077
Mitogen-activated protein kinase 130145
3-phosphoinositide-dependent protein kinase 10145
Mitogen-activated protein kinase kinase kinase 130044
Death-associated protein kinase 30044
Mitogen-activated protein kinase kinase kinase 70044
Receptor-interacting serine/threonine-protein kinase 20077
Mitotic checkpoint serine/threonine-protein kinase BUB10077
NUAK family SNF1-like kinase 10044
Dynamin-like 120 kDa protein, mitochondrial0077
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma0044
Tyrosine-protein kinase JAK203712
Eukaryotic translation initiation factor 5B0055
Rho-associated protein kinase 20178
Serine/threonine-protein kinase ULK10077
Serine/threonine-protein kinase/endoribonuclease IRE10077
Ribosomal protein S6 kinase alpha-50178
U5 small nuclear ribonucleoprotein 200 kDa helicase0077
Ribosomal protein S6 kinase alpha-40077
Serine/threonine-protein kinase 160077
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma0044
Serine/threonine-protein kinase PAK 30044
Cyclin-dependent kinase-like 50066
Serine/threonine-protein kinase 17B0044
Serine/threonine-protein kinase 100077
Serine/threonine-protein kinase D30178
Cyclin-dependent kinase 140044
Structural maintenance of chromosomes protein 20066
Mitogen-activated protein kinase kinase kinase 60077
Serine/threonine-protein kinase OSR10044
Mitogen-activated protein kinase kinase kinase kinase 40077
Serine/threonine-protein kinase LATS10077
Serine/threonine-protein kinase PAK 40077
Serine/threonine-protein kinase Chk20044
Tyrosine-protein kinase ABL104712
Interferon beta260026
HLA class I histocompatibility antigen, B alpha chain 190019
RAF proto-oncogene serine/threonine-protein kinase0044
Receptor tyrosine-protein kinase erbB-20549
High affinity nerve growth factor receptor0077
Guanine nucleotide-binding protein G(i) subunit alpha-20055
ADP/ATP translocase 20077
Protein kinase C beta type0178
Insulin receptor03710
Tyrosine-protein kinase Lck04711
Tyrosine-protein kinase Fyn0279
Cyclin-dependent kinase 10279
Glycogen phosphorylase, liver form0077
Tyrosine-protein kinase Fes/Fps0077
Macrophage colony-stimulating factor 1 receptor0044
Adenine phosphoribosyltransferase0055
Tyrosine-protein kinase Yes0077
Tyrosine-protein kinase Lyn0178
Proto-oncogene tyrosine-protein kinase receptor Ret0077
Insulin-like growth factor 1 receptor0279
Signal recognition particle receptor subunit alpha0077
Cytochrome c1, heme protein, mitochondrial0077
Hepatocyte growth factor receptor0077
Tyrosine-protein kinase HCK0077
Cytochrome P450 3A4012113
Proto-oncogene tyrosine-protein kinase ROS0044
Platelet-derived growth factor receptor beta0279
Tyrosine-protein kinase Fgr0077
Wee1-like protein kinase 20044
Uncharacterized serine/threonine-protein kinase SBK30044
Serine/threonine-protein kinase A-Raf0077
Cytochrome P450 2D60415
Mast/stem cell growth factor receptor Kit0246
Glycogen phosphorylase, brain form0077
Breakpoint cluster region protein02710
Serine/threonine-protein kinase pim-10077
Fibroblast growth factor receptor 10279
DNA topoisomerase 2-alpha0077
Cyclin-dependent kinase 40178
ADP/ATP translocase 30077
Inosine-5'-monophosphate dehydrogenase 20268
Proto-oncogene tyrosine-protein kinase Src0178
cAMP-dependent protein kinase type II-alpha regulatory subunit0066
Insulin receptor-related protein0044
Serine/threonine-protein kinase B-raf0077
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0077
Ribosyldihydronicotinamide dehydrogenase [quinone]03811
Platelet-derived growth factor receptor alpha0246
Tyrosine-protein kinase Fer0077
Protein kinase C alpha type02810
cAMP-dependent protein kinase catalytic subunit alpha0077
Vascular endothelial growth factor receptor 1 0246
General transcription and DNA repair factor IIH helicase subunit XPD0077
Interferon-induced, double-stranded RNA-activated protein kinase0044
Casein kinase II subunit alpha'0077
Ras-related protein Rab-6A0077
Serine/threonine-protein kinase MAK0044
Cyclin-dependent kinase 11B0044
Ephrin type-A receptor 10077
Fibroblast growth factor receptor 20145
Receptor tyrosine-protein kinase erbB-30044
Multifunctional protein ADE20077
Fibroblast growth factor receptor 40145
Fibroblast growth factor receptor 30145
cAMP-dependent protein kinase catalytic subunit gamma0066
cAMP-dependent protein kinase catalytic subunit beta0077
Ferrochelatase, mitochondrial0077
Ribosomal protein S6 kinase beta-10178
Tyrosine-protein kinase JAK103813
Protein kinase C eta type0145
Cyclin-dependent kinase 204711
Beta-adrenergic receptor kinase 10077
Probable ATP-dependent RNA helicase DDX60077
Activin receptor type-2A0044
Mitogen-activated protein kinase 3 0077
MAP/microtubule affinity-regulating kinase 30077
Deoxycytidine kinase0077
Mitogen-activated protein kinase 10077
Ephrin type-A receptor 20077
Ephrin type-A receptor 30044
Ephrin type-A receptor 80044
Ephrin type-B receptor 20077
Leukocyte tyrosine kinase receptor0044
Non-receptor tyrosine-protein kinase TYK203813
UMP-CMP kinase 0055
Phosphatidylethanolamine-binding protein 10055
Wee1-like protein kinase0077
Heme oxygenase 20077
Tyrosine-protein kinase receptor UFO0044
Mitogen-activated protein kinase 40044
S-adenosylmethionine synthase isoform type-20077
DnaJ homolog subfamily A member 10077
RAC-alpha serine/threonine-protein kinase0279
RAC-beta serine/threonine-protein kinase0077
G protein-coupled receptor kinase 40044
Dual specificity protein kinase TTK0077
DNA replication licensing factor MCM40066
Myosin-100066
Tyrosine-protein kinase receptor Tie-10044
Vascular endothelial growth factor receptor 30246
Vascular endothelial growth factor receptor 20448
Dual specificity mitogen-activated protein kinase kinase 20178
Receptor-type tyrosine-protein kinase FLT30178
Bone morphogenetic protein receptor type-1A0077
Activin receptor type-1B0077
TGF-beta receptor type-10077
Serine/threonine-protein kinase receptor R30066
TGF-beta receptor type-20077
Electron transfer flavoprotein subunit beta0055
Tyrosine-protein kinase CSK0178
Glycine--tRNA ligase0077
Protein kinase C iota type0178
Exosome RNA helicase MTR40077
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform0145
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform0044
Serine/threonine-protein kinase mTOR04610
Megakaryocyte-associated tyrosine-protein kinase0044
Tyrosine-protein kinase Tec0178
Tyrosine-protein kinase TXK0145
Tyrosine-protein kinase ABL20077
Tyrosine-protein kinase FRK0077
G protein-coupled receptor kinase 60066
Tyrosine-protein kinase ZAP-700044
Tyrosine-protein kinase SYK0077
26S proteasome regulatory subunit 6B0178
Mitogen-activated protein kinase 80178
Mitogen-activated protein kinase 90077
Dual specificity mitogen-activated protein kinase kinase 40055
Dual specificity mitogen-activated protein kinase kinase 30077
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha0066
Casein kinase I isoform alpha0077
Casein kinase I isoform delta0077
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0044
MAP kinase-activated protein kinase 20178
Cyclin-dependent kinase 80044
Elongation factor Tu, mitochondrial0077
Choline-phosphate cytidylyltransferase A0066
Cysteine--tRNA ligase, cytoplasmic0066
Casein kinase I isoform epsilon0077
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0077
Dual specificity protein kinase CLK10077
Dual specificity protein kinase CLK20077
Dual specificity protein kinase CLK30077
Glycogen synthase kinase-3 alpha0077
Glycogen synthase kinase-3 beta0178
Cyclin-dependent kinase 70077
Cyclin-dependent kinase 90077
Ras-related protein Rab-27A0066
Tyrosine-protein kinase Blk0145
Interleukin-1 receptor-associated kinase 10077
Ribosomal protein S6 kinase alpha-30178
Cytoplasmic tyrosine-protein kinase BMX0145
cAMP-dependent protein kinase catalytic subunit PRKX0044
Serine/threonine-protein kinase Nek20077
Serine/threonine-protein kinase Nek30077
Serine/threonine-protein kinase Nek40044
Tyrosine-protein kinase JAK303511
Dual specificity mitogen-activated protein kinase kinase 60077
Serine/threonine-protein kinase PLK104711
Death-associated protein kinase 10044
LIM domain kinase 10077
LIM domain kinase 20077
Mitogen-activated protein kinase 120145
Mitogen-activated protein kinase 100077
Tyrosine--tRNA ligase, cytoplasmic0066
5'-AMP-activated protein kinase subunit gamma-10077
5'-AMP-activated protein kinase catalytic subunit alpha-20044
Ephrin type-B receptor 30077
Ephrin type-A receptor 50077
Ephrin type-B receptor 40077
Ephrin type-B receptor 10044
Ephrin type-A receptor 40077
Adenylate kinase 2, mitochondrial0077
Adenosine kinase0077
Hormonally up-regulated neu tumor-associated kinase0044
Serine/threonine-protein kinase SIK10044
Receptor-interacting serine/threonine-protein kinase 40044
Spike glycoprotein161421
Ras-related protein Rab-100077
Cell division control protein 2 homolog0044
Actin-related protein 30077
Actin-related protein 20066
Calcium-dependent protein kinase 10044
GTP-binding nuclear protein Ran0077
Casein kinase II subunit alpha0044
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta0044
SRSF protein kinase 20044
Casein kinase I isoform gamma-20077
Mitogen-activated protein kinase kinase kinase 90044
Serine/threonine-protein kinase PknB0044
Cyclin-dependent kinase 30066
Cyclin-dependent kinase-like 10044
Cyclin-dependent kinase 60077
Cyclin-dependent-like kinase 5 0178
Cyclin-dependent kinase 160077
Cyclin-dependent kinase 170077
ATP-dependent 6-phosphofructokinase, platelet type0077
Protein kinase C epsilon type0145
Dual specificity mitogen-activated protein kinase kinase 10178
Angiopoietin-1 receptor0044
Mitogen-activated protein kinase kinase kinase 100044
DNA topoisomerase 2-beta0077
Protein kinase C theta type0178
Activin receptor type-10077
Macrophage-stimulating protein receptor0077
Focal adhesion kinase 10077
Protein kinase C zeta type0156
Protein kinase C delta type0178
Tyrosine-protein kinase BTK0178
Tyrosine-protein kinase receptor TYRO30044
Cyclin-dependent kinase 180066
Activated CDC42 kinase 10077
Epithelial discoidin domain-containing receptor 10077
Tyrosine-protein kinase ITK/TSK0145
Myotonin-protein kinase0044
Mitogen-activated protein kinase kinase kinase kinase 20077
Mitogen-activated protein kinase kinase kinase 120044
Tyrosine-protein kinase Mer0055
Serine/threonine-protein kinase 40077
5'-AMP-activated protein kinase catalytic subunit alpha-10077
Serine/threonine-protein kinase PAK 10145
Dual specificity mitogen-activated protein kinase kinase 50077
Mitogen-activated protein kinase 70077
Serine/threonine-protein kinase PAK 20077
Serine/threonine-protein kinase 30077
Mitogen-activated protein kinase kinase kinase 10077
cGMP-dependent protein kinase 20044
Integrin-linked protein kinase0077
Rho-associated protein kinase 10077
Non-receptor tyrosine-protein kinase TNK10077
Serine/threonine-protein kinase PRP4 homolog0044
Receptor-interacting serine/threonine-protein kinase 10044
Calcium/calmodulin-dependent protein kinase type II subunit beta0044
Calcium/calmodulin-dependent protein kinase type II subunit gamma0077
Calcium/calmodulin-dependent protein kinase type II subunit delta0077
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0077
Activin receptor type-2B0077
Bone morphogenetic protein receptor type-20077
Protein-tyrosine kinase 60077
cGMP-dependent protein kinase 1 0077
Cyclin-dependent kinase 130077
Calcium/calmodulin-dependent protein kinase type 10044
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0077
Protein-tyrosine kinase 2-beta0077
Maternal embryonic leucine zipper kinase0279
Structural maintenance of chromosomes protein 1A0066
Chromodomain-helicase-DNA-binding protein 40077
Peroxisomal acyl-coenzyme A oxidase 10066
Serine/threonine-protein kinase D10145
Serine/threonine-protein kinase 380044
Receptor tyrosine-protein kinase erbB-40246
Ribosomal protein S6 kinase alpha-20044
Ephrin type-A receptor 70066
Delta(24)-sterol reductase0066
Ribosomal protein S6 kinase alpha-10077
Dual specificity testis-specific protein kinase 10077
Myosin light chain kinase, smooth muscle0077
Mitogen-activated protein kinase 110178
Serine/threonine-protein kinase STK110077
Rhodopsin kinase GRK10044
NT-3 growth factor receptor0044
Serine/threonine-protein kinase N10077
Serine/threonine-protein kinase N20077
Mitogen-activated protein kinase 1403710
Calcium/calmodulin-dependent protein kinase type IV0077
Mitogen-activated protein kinase kinase kinase 110077
BDNF/NT-3 growth factors receptor0044
Mitogen-activated protein kinase 60044
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform0044
Discoidin domain-containing receptor 20077
AP2-associated protein kinase 10077
Myosin light chain kinase 30077
Serine/threonine-protein kinase SBK10044
Mitogen-activated protein kinase kinase kinase 190044
Putative heat shock protein HSP 90-beta 20077
Serine/threonine-protein kinase TNNI3K0044
Leucine-rich repeat serine/threonine-protein kinase 20044
Serine/threonine-protein kinase MRCK alpha0077
Serine/threonine-protein kinase MRCK gamma0077
Acyl-CoA dehydrogenase family member 100066
Serine/threonine-protein kinase Nek50044
Serine/threonine-protein kinase N30066
Serine/threonine-protein kinase ULK30077
Dual serine/threonine and tyrosine protein kinase0044
Mitogen-activated protein kinase kinase kinase 150044
Uncharacterized protein FLJ452520077
Acyl-CoA dehydrogenase family member 110066
Serine/threonine-protein kinase/endoribonuclease IRE20077
Serine/threonine-protein kinase MARK20077
ATP-dependent RNA helicase DHX300077
Serine/threonine-protein kinase TAO10077
STE20-related kinase adapter protein alpha0077
Myosin-140077
AarF domain-containing protein kinase 10077
Serine/threonine-protein kinase tousled-like 20044
Serine/threonine-protein kinase 32C0044
Serine/threonine-protein kinase pim-30044
ATP-dependent RNA helicase DDX420055
Serine/threonine-protein kinase VRK20044
Myosin light chain kinase family member 40044
Homeodomain-interacting protein kinase 10044
Calcium/calmodulin-dependent protein kinase type 1D0044
Mitogen-activated protein kinase kinase kinase kinase 30077
Cyclin-dependent kinase-like 30044
MAP kinase-activated protein kinase 50167
Serine/threonine-protein kinase BRSK20044
Serine/threonine-protein kinase NIM10044
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B0044
Serine/threonine-protein kinase ULK20044
Misshapen-like kinase 10066
Serine/threonine-protein kinase DCLK20044
Calcium/calmodulin-dependent protein kinase kinase 10044
Casein kinase I isoform alpha-like0044
Homeodomain-interacting protein kinase 40044
Myosin-IIIa0044
Ankyrin repeat and protein kinase domain-containing protein 10044
Serine/threonine-protein kinase Nek110044
Atypical kinase COQ8A, mitochondrial0077
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0077
Mitogen-activated protein kinase 150077
Serine/threonine-protein kinase Nek90077
Serine/threonine-protein kinase BRSK10044
Serine/threonine-protein kinase 350044
Serine/threonine-protein kinase Nek70055
Rhodopsin kinase GRK70044
Serine/threonine-protein kinase 32A0044
Myosin-IIIb0044
ATP-dependent RNA helicase DDX10077
Inositol hexakisphosphate kinase 1190019
Dual specificity tyrosine-phosphorylation-regulated kinase 20044
Cyclin-dependent kinase-like 20044
Mitogen-activated protein kinase kinase kinase kinase 10077
Serine/threonine-protein kinase Sgk30044
Atypical kinase COQ8B, mitochondrial0044
Aurora kinase B0077
MAP/microtubule affinity-regulating kinase 40077
Calcium/calmodulin-dependent protein kinase type 1G0055
Serine/threonine-protein kinase Nek10077
Cyclin-dependent kinase 150044
ATPase family AAA domain-containing protein 5160016
PAS domain-containing serine/threonine-protein kinase0077
Calcium/calmodulin-dependent protein kinase kinase 20077
EKC/KEOPS complex subunit TP53RK0077
SRSF protein kinase 10044
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0077
Mitogen-activated protein kinase kinase kinase 50077
Ataxin-2190019
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha0044
Mitogen-activated protein kinase kinase kinase 30077
Eukaryotic translation initiation factor 2-alpha kinase 10077
Serine/threonine-protein kinase RIO10044
MAP kinase-interacting serine/threonine-protein kinase 10044
Serine/threonine-protein kinase RIO20044
Cyclin-dependent kinase 190044
Transient receptor potential cation channel subfamily M member 60044
Testis-specific serine/threonine-protein kinase 10044
Serine/threonine-protein kinase 330044
Nucleolar GTP-binding protein 10077
Serine/threonine-protein kinase D20077
Serine/threonine-protein kinase DCLK30044
NUAK family SNF1-like kinase 20066
RNA cytidine acetyltransferase0077
Serine/threonine-protein kinase SIK20077
Myosin light chain kinase 2, skeletal/cardiac muscle0044
STE20-like serine/threonine-protein kinase 0077
Serine/threonine-protein kinase TAO30077
Homeodomain-interacting protein kinase 20044
Tyrosine-protein kinase Srms0044
Homeodomain-interacting protein kinase 30044
Serine/threonine-protein kinase PLK30246
dCTP pyrophosphatase 10077
Dual specificity protein kinase CLK40077
MAP kinase-interacting serine/threonine-protein kinase 20044
Serine/threonine-protein kinase Nek60044
Casein kinase I isoform gamma-10077
Serine/threonine-protein kinase PAK 60055
SNF-related serine/threonine-protein kinase0044
Serine/threonine-protein kinase LATS20044
Serine/threonine-protein kinase 360044
Phenylalanine--tRNA ligase beta subunit0077
BMP-2-inducible protein kinase0077
Obg-like ATPase 10055
Midasin0077
Interleukin-1 receptor-associated kinase 40077
Serine/threonine-protein kinase 32B0044
Mitogen-activated protein kinase kinase kinase 200077
Cyclin-dependent kinase 120077
Serine/threonine-protein kinase PLK20246
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 130066
Serine/threonine-protein kinase MARK10044
Serine/threonine-protein kinase pim-20055
Serine/threonine-protein kinase PAK 50044
Serine/threonine-protein kinase 260077
eIF-2-alpha kinase GCN20044
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0066
Serine/threonine-protein kinase NLK0077
Phosphatidylinositol 4-kinase beta0044
Serine/threonine-protein kinase 17A0044
STE20/SPS1-related proline-alanine-rich protein kinase0044
Ephrin type-A receptor 60044
5'-AMP-activated protein kinase subunit gamma-20077
Serine/threonine-protein kinase TBK10279
Septin-90077
Death-associated protein kinase 20044
Ribosomal protein S6 kinase alpha-60077
TRAF2 and NCK-interacting protein kinase0077
Serine/threonine-protein kinase tousled-like 10044
Serine/threonine-protein kinase TAO20077
Long-chain-fatty-acid--CoA ligase 50055
ALK tyrosine kinase receptor0044
SRSF protein kinase 30044
Serine/threonine-protein kinase ICK0066
Cyclin-dependent kinase 11A0044
Aurora kinase C0044
Calcium/calmodulin-dependent protein kinase type II subunit alpha0044
RAC-gamma serine/threonine-protein kinase0077
Serine/threonine-protein kinase 38-like0044
Microtubule-associated serine/threonine-protein kinase 10044
Serine/threonine-protein kinase SIK30077
Mitogen-activated protein kinase kinase kinase 20077
Thyroid hormone receptor-associated protein 30077
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0066
Mitogen-activated protein kinase kinase kinase kinase 50077
Receptor-interacting serine/threonine-protein kinase 30077
Serine/threonine-protein kinase MRCK beta0077
Interleukin-1 receptor-associated kinase 30077
Serine/threonine-protein kinase 240066
Casein kinase I isoform gamma-30077
Mitogen-activated protein kinase kinase kinase 40077
cytochrome P450 2C9, partial190019
ATAD5 protein, partial8008
Fumarate hydratase6006
Microtubule-associated protein tau8008
thioredoxin glutathione reductase2002
polyprotein6006
P532002
v-jun sarcoma virus 17 oncogene homolog (avian)140014
peripheral myelin protein 22 isoform 16006
cellular tumor antigen p53 isoform a4004
heat shock protein beta-1100010
survival motor neuron protein isoform d8008
cytochrome P450 3A4 isoform 1140014
M-phase phosphoprotein 85005
muscleblind-like protein 1 isoform 13003
Gamma-aminobutyric acid receptor subunit pi141015
Gamma-aminobutyric acid receptor subunit beta-1141015
Gamma-aminobutyric acid receptor subunit delta141015
Gamma-aminobutyric acid receptor subunit gamma-2141015
Gamma-aminobutyric acid receptor subunit alpha-5141015
Gamma-aminobutyric acid receptor subunit alpha-3141015
Gamma-aminobutyric acid receptor subunit gamma-1141015
Gamma-aminobutyric acid receptor subunit alpha-2141015
Gamma-aminobutyric acid receptor subunit alpha-4141015
Gamma-aminobutyric acid receptor subunit gamma-3141015
Gamma-aminobutyric acid receptor subunit alpha-6141015
Gamma-aminobutyric acid receptor subunit beta-3141015
Gamma-aminobutyric acid receptor subunit beta-2141015
GABA theta subunit141015
Gamma-aminobutyric acid receptor subunit epsilon141015
Protein-arginine deiminase type-40101
Chain H, Proteasome component PUP10101
Chain I, Proteasome component PUP30101
Chain K, Proteasome component PRE20101
Chain L, Proteasome component C50101
Chain K, Proteasome component PRE20101
Chain L, Proteasome component C50101
Proteasome subunit beta type-110101
nuclear receptor subfamily 1, group I, member 2100010
26S proteasome non-ATPase regulatory subunit 110101
26S proteasome non-ATPase regulatory subunit 120101
26S proteasome non-ATPase regulatory subunit 140101
Proteasome subunit alpha type-70101
Histone deacetylase 30303
26S proteasome non-ATPase regulatory subunit 30101
Carbonic anhydrase 120406
Prothrombin0101
Chymotrypsinogen A0101
Carbonic anhydrase 30406
Cathepsin B0101
Neutrophil elastase0101
Cathepsin G0202
Lysosomal protective protein0101
Chymotrypsinogen B0101
26S proteasome regulatory subunit 6A0101
Nuclear factor NF-kappa-B p105 subunit0304
Proteasome subunit beta type-10102
Carbonic anhydrase 40406
Carbonic anhydrase 60406
Chymase0101
Proteasome subunit alpha type-10101
Proteasome subunit alpha type-20101
Proteasome subunit alpha type-30101
Proteasome subunit alpha type-40101
Proteasome subunit beta type-80101
Proteasome subunit beta type-80101
Proteasome subunit beta type-90101
Proteasome subunit alpha type-50101
Proteasome subunit beta type-40101
Proteasome subunit beta type-60101
Proteasome subunit beta type-50203
Carbonic anhydrase 5A, mitochondrial0406
26S proteasome regulatory subunit 70101
Lon protease homolog, mitochondrial0101
Proteasome subunit beta type-100101
Carbonic anhydrase 70406
26S proteasome non-ATPase regulatory subunit 80101
Proteasome subunit beta type-30101
Proteasome subunit beta type-20102
26S proteasome non-ATPase regulatory subunit 70101
26S proteasome non-ATPase regulatory subunit 40101
26S proteasome complex subunit SEM10101
Proteasome subunit alpha type-60101
26S proteasome regulatory subunit 40101
26S proteasome regulatory subunit 80101
26S proteasome regulatory subunit 10B0101
Beta-carbonic anhydrase 10202
Nuclear factor NF-kappa-B p100 subunit 0303
Transcription factor p650303
26S proteasome non-ATPase regulatory subunit 20101
26S proteasome non-ATPase regulatory subunit 60101
Proteasomal ubiquitin receptor ADRM10101
Carbonic anhydrase 90507
ATP-dependent Clp protease proteolytic subunit0112
Carbonic anhydrase 130304
NACHT, LRR and PYD domains-containing protein 3 0101
Proteasome subunit alpha-type 80101
Proteasome subunit beta type-70101
26S proteasome non-ATPase regulatory subunit 10101
Carbonic anhydrase 150304
Histone deacetylase 80303
Carbonic anhydrase 140406
26S proteasome non-ATPase regulatory subunit 130101
Carbonic anhydrase 5B, mitochondrial0406
Chain A, Carbonic anhydrase II0101
Carbonic anhydrase 0001
Carbonic anhydrase 0202
pregnane X receptor4004
hypoxia-inducible factor 1 alpha subunit8008
USP1 protein, partial110011
Carbonic anhydrase 0202
Carbonic anhydrase 0101
67.9K protein5005
Carbonic anhydrase0101
thyrotropin-releasing hormone receptor3003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a100010
interferon gamma precursor0002
prostaglandin E2 receptor EP2 subtype1002
nuclear factor erythroid 2-related factor 2 isoform 29009
potassium voltage-gated channel subfamily H member 2 isoform d5005
Prostaglandin E synthase0101
cGMP-specific 3',5'-cyclic phosphodiesterase0202
Cytochrome c oxidase subunit 10101
Cytochrome c oxidase subunit 20101
Catechol O-methyltransferase0101
Cytochrome c oxidase subunit 20101
Procathepsin L0246
Aldo-keto reductase family 1 member B1010010
Neuronal acetylcholine receptor subunit alpha-40202
Polyunsaturated fatty acid 5-lipoxygenase0404
Quinolone resistance protein NorA0101
Adenosine receptor A30909
Neuronal acetylcholine receptor subunit beta-20202
Alpha-1B adrenergic receptor011112
Calpain-2 catalytic subunit0101
Alpha-2B adrenergic receptor010010
5-hydroxytryptamine receptor 1A0506
D(1A) dopamine receptor0606
Prostaglandin G/H synthase 10101
Sodium-dependent noradrenaline transporter 010111
Cruzipain0101
Sodium/hydrogen exchanger 10101
Indoleamine 2,3-dioxygenase 10101
Sodium-dependent serotonin transporter010010
Sodium-dependent serotonin transporter0314
Delta-type opioid receptor0202
Mu-type opioid receptor0213
Bifunctional epoxide hydrolase 20303
Prostaglandin G/H synthase 2 0101
Carbonic anhydrase0102
Alpha-1A adrenergic receptor011112
Carbonic anhydrase0103
Histone deacetylase 40202
D(2) dopamine receptor0303
Carbonic anhydrase 0101
Mu-type opioid receptor0314
Carbonic anhydrase 20101
Sodium-dependent dopamine transporter 0808
Prostaglandin G/H synthase 20101
Carbonic anhydrase, alpha family 0202
Carbonic anhydrase 0103
Carbonic anhydrase0103
Carbonic anhydrase0103
Carbonic anhydrase 0202
Sigma intracellular receptor 20202
Delta carbonic anhydrase0202
Prostaglandin G/H synthase 1 0101
Carbonic anhydrase 0103
Prostaglandin G/H synthase 10101
Cyclooxygenase-2 0101
Histone deacetylase 70202
Rap guanine nucleotide exchange factor 43003
Carbonic anhydrase 40203
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0202
P2Y purinoceptor 120101
Histone deacetylase 90202
Histone deacetylase 50202
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0101
Spike glycoprotein0145
Replicase polyprotein 1ab0145
glucose-6-phosphate 1-dehydrogenase isoform b0101
Transmembrane protease serine 20145
Dihydrofolate reductase 0101
DNA ligase0101
Riboflavin-binding protein0011
Major prion protein0011
Amyloid-beta precursor protein0213
Histidine-rich protein PFHRP-II0102
Muscarinic acetylcholine receptor M20707
Muscarinic acetylcholine receptor M40606
Muscarinic acetylcholine receptor M50606
Alpha-2A adrenergic receptor0909
Replicase polyprotein 1a0145
Replicase polyprotein 1ab0145
Replicase polyprotein 1ab0246
Spike glycoprotein0101
Replicase polyprotein 1ab0246
Muscarinic acetylcholine receptor M10606
Alpha-2C adrenergic receptor0606
DNA ligase 10101
Muscarinic acetylcholine receptor M30808
Nuclear receptor subfamily 4 group A member 20022
Beta-secretase 10101
Calcium-dependent protein kinase 10011
MO15-related protein kinase Pfmrk 0101
DNA ligase A0101
Potassium voltage-gated channel subfamily H member 20909
Sigma intracellular receptor 20202
Phosphoethanolamine N-methyltransferase0101
Angiotensin-converting enzyme 2 0145
Cysteine proteinase falcipain 2a 0101
Cysteine proteinase falcipain 2a 0101
importin subunit beta-1 isoform 13003
mitogen-activated protein kinase 12002
snurportin-13003
GTP-binding nuclear protein Ran isoform 13003
urokinase-type plasminogen activator precursor6006
plasminogen precursor6006
urokinase plasminogen activator surface receptor precursor6006
streptokinase A precursor0022
parathyroid hormone/parathyroid hormone-related peptide receptor precursor4004
Rap guanine nucleotide exchange factor 33003
Estrogen receptor016525
Glucocorticoid receptor012320
Sex hormone-binding globulin0033
Cytochrome P450 1A20303
Glycine receptor subunit alpha-1012012
Androgen receptor015015
Glycine receptor subunit beta012012
Substance-K receptor0606
Glycine receptor subunit alpha-2012012
Glycine receptor subunit alpha-3012012
5-hydroxytryptamine receptor 2A0808
Mu-type opioid receptor0404
D(3) dopamine receptor0606
Kappa-type opioid receptor0404
Solute carrier family 22 member 20002
Solute carrier organic anion transporter family member 1A50001
Prostaglandin E2 receptor EP3 subtype0101
Prostaglandin E2 receptor EP4 subtype0101
Prostaglandin E2 receptor EP1 subtype0213
Prostaglandin E2 receptor EP1 subtype0101
Prostaglandin E2 receptor EP4 subtype0213
Prostaglandin F2-alpha receptor0011
Prostaglandin E2 receptor EP4 subtype0112
Prostaglandin E2 receptor EP3 subtype0213
Prostaglandin E2 receptor EP2 subtype0213
Prostacyclin receptor0213
Solute carrier organic anion transporter family member 2A10001
Solute carrier family 22 member 70001
Prostaglandin E2 receptor EP2 subtype0101
Prostaglandin E2 receptor EP2 subtype0112
Solute carrier family 22 member 70001
Solute carrier organic anion transporter family member 2A10001
Solute carrier family 22 member 110001
Solute carrier organic anion transporter family member 1B20001
Solute carrier family 22 member 70001
Chain A, Beta-lactamase110011
Chain A, JmjC domain-containing histone demethylation protein 3A5005
chaperonin-containing TCP-1 beta subunit homolog1001
bromodomain adjacent to zinc finger domain 2B6006
ubiquitin-conjugating enzyme E2 N0303
protein AF-9 isoform a0001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
nuclear receptor ROR-gamma isoform 19009
5-hydroxytryptamine receptor 40404
5-hydroxytryptamine receptor 2C0606
C-8 sterol isomerase0202
Alpha-synuclein5106
5-hydroxytryptamine receptor 2B0707
5-hydroxytryptamine receptor 60505
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0314
Endothelin-1 receptor0101
Capsid protein 0011
endonuclease IV2002
NFKB1 protein, partial4004
GALC protein8008
nonstructural protein 15005
hexokinase-4 isoform 12002
chromobox protein homolog 1100010
glucokinase regulatory protein2002
Corticosteroid-binding globulin0202
Steryl-sulfatase0202
Aromatase0505
Polyunsaturated fatty acid lipoxygenase ALOX150101
17-beta-hydroxysteroid dehydrogenase type 10203
Solute carrier organic anion transporter family member 1A10101
Inositol monophosphatase 12002
TAR DNA-binding protein 434004
Cytochrome P450 1B10303
Estrogen receptor beta09313
Ghrelin O-acyltransferase0101
Albumin0123
Luciferin 4-monooxygenase0202
Tyrosine-protein phosphatase non-receptor type 10202
Tyrosine-protein phosphatase 10101
Ectonucleotide pyrophosphatase/phosphodiesterase family member 20202
Vesicular glutamate transporter 30101
Potassium voltage-gated channel subfamily E member 10202
Potassium voltage-gated channel subfamily KQT member 10202
Sodium channel protein type 5 subunit alpha0202
Regulatory-associated protein of mTOR0202
Dual specificity testis-specific protein kinase 20044
Target of rapamycin complex subunit LST80202
Potassium voltage-gated channel subfamily D member 30101
15-lipoxygenase, partial2002
Neuraminidase0101
Amine oxidase [flavin-containing] B0102
Amine oxidase [flavin-containing] A0202
UDP-glucuronosyltransferase 1A1 0102
Amine oxidase [flavin-containing] B0202
Amine oxidase [flavin-containing] B0101
Amine oxidase [flavin-containing] B0101
Guanine nucleotide-binding protein G5005
Nuclear receptor subfamily 1 group I member 20044
Estrogen receptor0113
Progesterone receptor0719
Steroid hormone receptor ERR10202
Beta-lactamase TEM0101
Bile acid receptor0101
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
Hypoxanthine-guanine phosphoribosyltransferase0001
Ricin0101
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase0011
Purine nucleoside phosphorylase 0012
Shiga toxin subunit A0101
Guanine deaminase0001
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Protein (female-specific Histamine Binding Protein 2)0011
aryl hydrocarbon receptor nuclear translocator0001
apical membrane antigen 1, AMA12002
transforming acidic coiled-coil-containing protein 30001
Solute carrier family 22 member 30102
Plasma kallikrein0001
Macrophage migration inhibitory factor0202
Histamine H2 receptor0527
5-hydroxytryptamine receptor 1D0001
Histamine H1 receptor0235
Histamine H1 receptor0213
Metabotropic glutamate receptor 50112
Histamine H1 receptor0224
Glutamate receptor ionotropic, NMDA 1 0001
Histamine H2 receptor7018
Histamine H3 receptor0101
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0102
Glutamate receptor ionotropic, NMDA 2C0001
Histamine N-methyltransferase 0101
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase-like protein, putative0001
Glutamate receptor ionotropic, NMDA 2D0001
Solute carrier family 22 member 10102
Equilibrative nucleoside transporter 40001
Glutamate receptor ionotropic, NMDA 3B0001
Histamine H4 receptor0123
Histamine H4 receptor0123
Histamine H4 receptor 0101
Carbonic anhydrase 130103
Histamine H4 receptor0123
Histamine H3 receptor0202
Carboxylic ester hydrolase 0001
Solute carrier family 22 member 20102
Glutamate receptor ionotropic, NMDA 3A0001
Histamine H3 receptor0123
Hsf1 protein0011
cytochrome P450 2C9 precursor4004
Genome polyprotein 0101
Alpha-1D adrenergic receptor0404
Cyclic GMP-AMP synthase0101
Toll-like receptor 90101
Toll-like receptor 70101
Chain A, Cell Division Protein Kinase 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, Cell Division Protein Kinase 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, Cell Division Protein Kinase 20101
DNA repair and recombination protein RadA0011
Heat shock protein HSP 90-alpha0011
G2/mitotic-specific cyclin-B10101
Indoleamine 2,3-dioxygenase 10011
Cyclin-A20101
Nitric oxide synthase, brain0101
Cyclin-A10101
Cytochrome P450 1440011
Steroid C26-monooxygenase0011
Steroid C26-monooxygenase0011
Chain A, Epidermal growth factor receptor0101
dual specificity tyrosine-phosphorylation-regulated kinase 1A0001
Membrane-associated progesterone receptor component 10033
Myosin light chain kinase, smooth muscle0022
Cytochrome P450 3A50202
G1/S-specific cyclin-E10101
D(1A) dopamine receptor3104
Tubulin alpha-1A chain0022
Serine/threonine-protein kinase ATR0033
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Cyclin-dependent kinase 100033
Uncharacterized aarF domain-containing protein kinase 50044
Rab-like protein 30044
Isoleucine--tRNA ligase, mitochondrial0033
Alpha-1A adrenergic receptor 0101
cytochrome P450 2C19 precursor2002
runt-related transcription factor 1 isoform AML1b1001
core-binding factor subunit beta isoform 21001
Cytochrome P450 11B1, mitochondrial0101
Cytochrome P450 11B2, mitochondrial0101
Amine oxidase [flavin-containing] A 0102
Gonadotropin-releasing hormone receptor0101
Gonadotropin-releasing hormone receptor0202
N-formyl peptide receptor 20101
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
5-hydroxytryptamine receptor 1A0101
Type-1 angiotensin II receptor0101
HLA class I histocompatibility antigen, A alpha chain 0101
5-hydroxytryptamine receptor 2C0415
5-hydroxytryptamine receptor 2A0415
5-hydroxytryptamine receptor 2B0314
Gastrin/cholecystokinin type B receptor0101
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)6006
PINK13003
Parkin4004
Cytochrome P450 2C190404
transcriptional regulator ERG isoform 32002
neuropeptide S receptor isoform A2002
Mineralocorticoid receptor 0426
Androgen receptor0426
Androgen receptor0011
5-hydroxytryptamine receptor 1B0303
Aldo-keto reductase family 1 member C30101
Aldo-keto reductase family 1 member C2 0101
Aldo-keto reductase family 1 member C10101
galanin receptor type 30101
Nuclear receptor subfamily 1 group I member 20011
Chain A, Inosine-5'-Monophosphate Dehydrogenase 20101
UDP-glucuronosyltransferase 1A90001
Glutamate receptor 10101
Glutamate receptor 30101
Glutamate receptor 40101
Inosine-5'-monophosphate dehydrogenase 1 0202
Peroxisome proliferator-activated receptor gamma0011
Inosine-5'-monophosphate dehydrogenase0102
UDP-glucuronosyltransferase 1A70001
UDP-glucuronosyltransferase 1A100001
UDP-glucuronosyltransferase 1A80001
Platelet-derived growth factor receptor beta0101
Platelet-derived growth factor receptor alpha 0101
Vascular endothelial growth factor receptor 20101
Chain A, Poly(adp-ribose) Polymerase0101
Chain A, Poly(adp-ribose) Polymerase0101
Chain A, Poly(adp-ribose) Polymerase0101
cytochrome P450 2D6 isoform 13003
Poly [ADP-ribose] polymerase 1 0101
Poly [ADP-ribose] polymerase tankyrase-10101
Cholinesterase0202
Protein mono-ADP-ribosyltransferase PARP60101
Protein mono-ADP-ribosyltransferase PARP150101
Protein mono-ADP-ribosyltransferase PARP100112
Protein mono-ADP-ribosyltransferase PARP80011
Protein mono-ADP-ribosyltransferase PARP160112
Protein mono-ADP-ribosyltransferase PARP120101
Poly [ADP-ribose] polymerase tankyrase-20101
Poly [ADP-ribose] polymerase 20123
Protein mono-ADP-ribosyltransferase PARP40112
Protein mono-ADP-ribosyltransferase PARP30123
Geranylgeranyl pyrophosphate synthase0101
Farnesyl pyrophosphate synthase0202
Hypoxanthine-guanine phosphoribosyltransferase0101
Farnesyl pyrophosphate synthase 0101
ClpP2002
Transforming growth factor beta-1 proprotein0101
Mothers against decapentaplegic homolog 3 0101
luciferase0001
Glucocorticoid receptor0213
Glucocorticoid receptor0011
Glutamine synthetase0011
Nociceptin receptor0011
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
heat shock protein HSP 90-alpha isoform 20001
Polyunsaturated fatty acid lipoxygenase ALOX15B5005
heat shock protein 90, putative0001
Thrombopoietin2002
Interleukin-50101
Interleukin-50101
Matrix metalloproteinase-90101
Interleukin-5 receptor subunit alpha0101
Chain A, Troponin C, slow skeletal and cardiac muscles0011
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
BRCA11001
pyruvate kinase2002
M18 aspartyl aminopeptidase0101
cathepsin L10101
lysosomal alpha-glucosidase preproprotein1001
NPC intracellular cholesterol transporter 1 precursor3003
huntingtin isoform 21001
DNA polymerase beta2002
atrial natriuretic peptide receptor 2 precursor1001
nuclear factor NF-kappa-B p105 subunit isoform 10011
ras-related protein Rab-9A3003
serine/threonine-protein kinase mTOR isoform 13003
FAD-linked sulfhydryl oxidase ALR0001
Vif0202
DNA dC->dU-editing enzyme APOBEC-3G isoform 11203
transcription factor p65 isoform 10011
serine/threonine-protein kinase 33 isoform a0011
POsterior Segregation0011
Aryl hydrocarbon receptor0101
Estrogen receptor beta0011
Acetylcholinesterase0202
Polyphenol oxidase 20101
Lysine-specific histone demethylase 1A0101
Transient receptor potential cation channel subfamily A member 10123
Myc proto-oncogene protein0102
Transthyretin0011
Cytochrome P450 1A10101
Cathepsin D0101
DNA polymerase alpha catalytic subunit0101
Leukotriene A-4 hydrolase0101
Tyrosinase0303
Ornithine decarboxylase0101
Tyrosinase0101
Estrogen receptor0011
Endothelin receptor type B1102
Acetylcholinesterase0101
Sucrase-isomaltase, intestinal0101
Endothelin-1 receptor1001
Dipeptidyl peptidase 40101
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 10101
Nitric oxide synthase, inducible0101
Cannabinoid receptor 10101
Alpha-glucosidase MAL120101
Cholinesterase0101
Squalene synthase0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0001
Bcl-2-like protein 10101
Nuclear factor erythroid 2-related factor 20012
N1L 0101
NAD(P)H dehydrogenase [quinone] 10003
Tubulin beta-2B chain0101
Lysosomal alpha-glucosidase0101
Transient receptor potential cation channel subfamily A member 10101
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
NAD-dependent protein deacetylase sirtuin-20011
NAD-dependent protein deacetylase sirtuin-10013
Prenyltransferase homolog0001
NAD-dependent protein deacetylase sirtuin-3, mitochondrial0011
Zinc finger protein mex-50011
large T antigen0101
NS5 0011
alpha-galactosidase2002
glycogen synthase kinase-3 beta isoform 10011
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Polymerase basic protein 20011
RNA-directed RNA polymerase catalytic subunit0011
Polymerase acidic protein0011
Adenosylhomocysteinase0002
Adenosine receptor A2a0303
Adenosine receptor A10303
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Adenosine receptor A10101
Genome polyprotein0011
DNA polymerase III, partial2002
D(1A) dopamine receptor2002
pyruvate kinase PKM isoform b1001
5-hydroxytryptamine receptor 1A0011
Ornithine decarboxylase1001
Diacylglycerol kinase alpha0101
Alpha-1D adrenergic receptor0314
Endothelin receptor type B0101
5-hydroxytryptamine receptor 7 0101
5-hydroxytryptamine receptor 2C 0101
5-hydroxytryptamine receptor 70101
5-hydroxytryptamine receptor 2A0101
5-hydroxytryptamine receptor 2B0101
DNA polymerase eta isoform 11001
Protein-S-isoprenylcysteine O-methyltransferase0101
Protein-S-isoprenylcysteine O-methyltransferase 0101
Chain A, Lysr-type Regulatory Protein0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, 146aa long hypothetical transcriptional regulator0011
Chain A, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Chain B, Anthranilate phosphoribosyltransferase0101
Chain C, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Anthranilate phosphoribosyltransferase0101
photoreceptor-specific nuclear receptor0101
serine/threonine-protein kinase PLK11001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
3-hydroxy-3-methylglutaryl-coenzyme A reductase0101
Sigma non-opioid intracellular receptor 10101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Eukaryotic translation initiation factor 4E0011
Peptidyl-prolyl cis-trans isomerase FKBP1A0101
Peptidyl-prolyl cis-trans isomerase FKBP1A0426
Peptidyl-prolyl cis-trans isomerase FKBP1B0022
Peptidyl-prolyl cis-trans isomerase FKBP50202
Programmed cell death protein 40011
Serine/threonine-protein kinase mTOR 0101
UDP-glucuronosyltransferase 2B70001
UDP-glucuronosyltransferase 1A40002
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0202
Splicing factor 3B subunit 30101
Chain A, CES1 protein0101
Lysosomal acid glucosylceramidase0011
Protein kinase C gamma type0101
Protein kinase C alpha type0101
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Transcriptional activator protein LuxR0101
Angiotensin-converting enzyme0202
D(2) dopamine receptor0202
Cytochrome P450 2B60101
D(4) dopamine receptor0202
Thromboxane-A synthase 0101
Substance-P receptor0202
B2 bradykinin receptor0202
Melanocortin receptor 40202
Melanocortin receptor 50202
Delta-type opioid receptor0202
Melanocortin receptor 30202
Estrogen-related receptor gamma0101
Protein kinase C gamma type0101
Protein kinase C beta type0101
Phospholipase D1 0101
Platelet-activating factor acetylhydrolase0101
Phospholipase D10101
Estrogen receptor beta0012
Protein kinase C eta type0101
Nuclear receptor subfamily 3 group C member 3 0202
Emopamil-binding protein-like0101
7-dehydrocholesterol reductase0112
Protein kinase C theta type0101
Chain A, Tyrosine-protein kinase0101
Chain A, Tyrosine-protein kinase0101
Chain A, Tyrosine-protein kinase JAK20101
Serine/threonine-protein kinase Sgk10101
Cytochrome P450 2C80101
Cytochrome P450 2A60101
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial0101
Tyrosine-protein kinase JAK30101
Tyrosine-protein kinase JAK20101
Tyrosine-protein kinase JAK30101
MAP kinase-activated protein kinase 30011
Alpha-2B adrenergic receptor0202
Alpha-2C adrenergic receptor0202
Alpha-2A adrenergic receptor0202
Sodium-dependent dopamine transporter0101
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 5A0101
Nischarin0101
Nuclear receptor subfamily 2 group E member 10011
D-alanyl-D-alanine dipeptidase0101
Transporter0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]