Page last updated: 2024-08-24

triazoles and allopurinol

triazoles has been researched along with allopurinol in 66 studies

Research

Studies (66)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (9.09)	18.7374
1990's	8 (12.12)	18.2507
2000's	2 (3.03)	29.6817
2010's	37 (56.06)	24.3611
2020's	13 (19.70)	2.80

Authors

Authors	Studies
Baer, JE; Baldwin, JJ; Duggan, DE; Noll, RM; Novello, FC	1
Baldwin, JJ; Duggan, DE; Kasinger, PA; Novello, FC; Sprague, JM	1
Levine, BA; McCollum, MO; Olson, MS; Zhou, W	1
Arison, BH; Baldwin, JJ; Duggan, DE; Rhodes, RE	1
Bergmann, F; Kwietny-Govrin, H; Ungar-Waron, H	1
Blake, DA; Cascorbi, HF; Meyer, FJ; Rozman, RS	1
Durack, DT; Smego, RA	1
Biagi, G; Costantino, L; Giorgi, I; Livi, O; Scartoni, V; Tonetti, I	1
Anderson, DC; Gaboury, JP; Kubes, P	1
Baroggi, N; Braquet, P; Defaux, JP; Etienne, A; Thonier, F	1
Cook, JA; Grisham, MB; Jourd'heuil, D; Kim, SY; Krishna, MC; Miles, AM; Mitchell, JB; Pacelli, R; Russo, A; Vodovotz, Y; Wink, DA	1
Alexander, JS; Aw, TY; Coe, L; Granger, DN; Ichikawa, H; Ohno, N; Wolf, RE; Yoshikawa, T	1
Shchepetkin, IA	1
Schepetkin, IA	1
Kamendulis, LM; Klaunig, JE; Zhang, H	1
Antunes, C; Böhmer, AE; Elisabetsky, E; Lara, DR; Porciúncula, LO; Schallenberger, C; Schmidt, AP; Souza, DO	1
Bodade, RG; Dawane, BS; Khandare, NT; Khobragade, CN; Konda, SG	1
Ball, C; Bejot, R; Carroll, L; Elizarov, AM; Gouverneur, V; Hill, S; Kelly, C; Kersemans, V; King, RC; Kolb, HC; Miraghaie, R; Smart, S; Zhang, J	1
Bhalodia, Y; Manek, R; Sheth, N; Vaghasiya, J	1
Cravets, M; Miner, JN; Perez-Ruiz, F; Storgard, C; Sundy, JS	1
Hoy, SM	1
Adler, S; Baumgartner, S; Becker, MA; Bhakta, N; Fitz-Patrick, D; Fung, M; Kopicko, J; Saag, KG; Storgard, C	1
Adler, S; Bardin, T; Baumgartner, S; Bhakta, N; Fung, M; Keenan, RT; Khanna, PP; Kopicko, J; So, A; Storgard, C	1
Gillen, M; Harmon, E; Kerr, B; Lee, CA; Nguyen, M; Shen, Z; Tieu, K; Wilson, DM	1
Saag, KG	1
Abeles, AM	1
Singh, JA	2
Li, SY; Meng, FH; Sun, Q; Wang, L; Wu, QX; Yang, S; Yuan, WY; Zhang, TJ	1
Deeks, ED	1
Gao, H; Li, SY; Meng, FH; Sun, Q; Wang, L; Wu, QX; Zhang, TJ; Zhang, Y	1
Hill-McManus, D; Hughes, D; Lane, S; Marshall, S; Soto, E	2
Schechter, B; Valiyil, R	1
Adler, S; Alten, R; Baumgartner, S; Bhakta, N; Dalbeth, N; Fung, M; Kopicko, J; Saag, K; Storgard, C; Tausche, AK	1
Aksenov, S; Eriksson, UG; Peck, CC; Stanski, DR	1
Kuehn, BM	1
Basile, M; Cicchetti, A; Drago, C; Rolli, FR; Ruggeri, M	1
Baumgartner, S; Kerr, B; Manhard, K; Quart, B; Shen, Z; Yeh, LT	1
Bly, CA; Cinfio, FN; Kabadi, S; Klein, RW; Szymanski, KA; Taylor, DC	1
Baumgartner, S; Goldfarb, DS; Jalal, D; Pillinger, M; Saag, KG; Schechter, BM; Terkeltaub, R; Valiyil, R; White, WB	1
Jansen, TL; Perez-Ruiz, F; Richette, P; Tausche, AK	1
Robinson, PC	1
Fields, TR	1
Bartsch, LA; Castillo-Rodriguez, E; Fernandez-Prado, R; Kanbay, M; Ortiz, A; Perez-Gomez, MV	1
Gupta, MK; Singh, JA	1
Alam, O; Ezzeldin, E; Herqash, RN; Iqbal, M	1
Li, SY; Meng, FH; Olounfeh, KM; Wu, QX; Zhang, TJ; Zhang, Y	1
Lee, YH; Song, GG	1
Boran, A; Chen, Y; Gallo, J; Goldfarb, J; Hu, Y; Iyengar, R; Jayaraman, G; Li, L; Mariottini, C; Tavassoly, I; Tolentino, RE; Zhao, S	1
Oyagüez, I; Pérez-Ruiz, F; Presa, M	1
Nguyen, M; Sun, L; Wilson, DM; Yeh, LT; Zhou, D	1
Alghamdi, YS; Nassan, MA; Soliman, MM	1
Abdelazim, AH; Attia, KAM; El-Olemy, A; Hasan, MA; Omar, MKM; Ramzy, S; Shahin, M	1
Desai, RJ; Kim, E; Kim, SC; Lii, J; Neogi, T	1
Abdelazim, AH; El-Olemy, A; Mohamed, AA; Omar, MKM; Ramzy, S; Shahin, M	1
Borghi, C; Cicero, AFG; Fogacci, F; Kuwabara, M	1
Abdelazim, AH; Shahin, M	1
Al-Khafaji, K; Altundas, A; Ates, B; Noma, SAA; Taskin-Tok, T; Yagiz, G	1
Bombardier, C; Edwards, CJ; Pardo Pardo, J; Sriranganathan, MK; Vinik, O	1
Guo, S; Hu, SS; Lu, PF; Meng, FH; Wang, ZR; Zhang, TJ; Zhang, X; Zhang, Y; Zhang, ZH	1
Bedi, PMS; Bhagat, K; Chadha, R; Gulati, HK; Heer, S; Kaur, G; Kaur, K; Kumar, N; Sharma, A; Singh, A; Singh, H; Singh, JV	1
Abd Elhalim, LM; Abdelazim, AH; Abourehab, MAS; Almrasy, AA; Ramzy, S	1
Cheng, H; Hou, X; Li, X; Nan, G; Ren, L; Tian, J; Xiao, Z; Yan, D; Yang, Y; Ye, F	1

Reviews

11 review(s) available for triazoles and allopurinol

Article	Year
Lesinurad: First Global Approval. Drugs, 2016, Volume: 76, Issue:4 Topics: Clinical Trials as Topic; Enzyme Inhibitors; Gout; Humans; Hyperuricemia; Thioglycolates; Triazoles; Uricosuric Agents; Xanthine Oxidase	2016
Lesinurad (Zurampic) for gout-associated hyperuricemia. The Medical letter on drugs and therapeutics, 2016, Nov-21, Volume: 58, Issue:1508 Topics: Clinical Trials as Topic; Gout; Humans; Hyperuricemia; Thioglycolates; Triazoles; Uricosuric Agents; Xanthine Oxidase	2016
Lesinurad: A Review in Hyperuricaemia of Gout. Drugs & aging, 2017, Volume: 34, Issue:5 Topics: Adult; Allopurinol; Drug Therapy, Combination; Enzyme Inhibitors; Febuxostat; Gout; Humans; Hyperuricemia; Kidney; Middle Aged; Organic Anion Transporters; Organic Cation Transport Proteins; Thioglycolates; Treatment Outcome; Triazoles; Uric Acid; Uricosuric Agents; Xanthine Oxidase	2017
International position paper on the appropriate use of uricosurics with the introduction of lesinurad. Clinical rheumatology, 2018, Volume: 37, Issue:12 Topics: Benzbromarone; Europe; Febuxostat; Gout; Humans; International Cooperation; Practice Guidelines as Topic; Probenecid; Rheumatology; Thioglycolates; Triazoles; Uricosuric Agents; Xanthine Oxidase	2018
Gout - An update of aetiology, genetics, co-morbidities and management. Maturitas, 2018, Volume: 118 Topics: Allopurinol; Chronic Disease; Comorbidity; Diet; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Probenecid; Thioglycolates; Triazoles; Uric Acid	2018
The Challenges of Approaching and Managing Gout. Rheumatic diseases clinics of North America, 2019, Volume: 45, Issue:1 Topics: Acetamides; Allopurinol; Antibodies, Monoclonal, Humanized; Colchicine; Diet Therapy; Febuxostat; Gout; Gout Suppressants; Humans; Medication Adherence; Patient Education as Topic; Phenylacetates; Polyethylene Glycols; Quality of Health Care; Rheumatology; Thioglycolates; Triazoles; Urate Oxidase; Uric Acid	2019
Potential Dangers of Serum Urate-Lowering Therapy. The American journal of medicine, 2019, Volume: 132, Issue:4 Topics: Cardiovascular Diseases; Gout Suppressants; Humans; Oxidative Stress; Polyethylene Glycols; Thioglycolates; Triazoles; Urate Oxidase; Uric Acid; Xanthine Oxidase	2019
Cardiovascular Disease in Gout and the Protective Effect of Treatments Including Urate-Lowering Therapy. Drugs, 2019, Volume: 79, Issue:5 Topics: Allopurinol; Anti-Inflammatory Agents; Cardiovascular Diseases; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Thioglycolates; Treatment Outcome; Triazoles; Uric Acid	2019
Comparative efficacy and safety of lesinurad 200 mg and 400 mg combined with a xanthine oxidase inhibitor in hyperuricemic patients with gout: A Bayesian network meta-analysis of randomized controlled trials . International journal of clinical pharmacology and therapeutics, 2019, Volume: 57, Issue:7 Topics: Bayes Theorem; Drug Therapy, Combination; Gout; Humans; Network Meta-Analysis; Randomized Controlled Trials as Topic; Thioglycolates; Triazoles; Uric Acid; Xanthine Oxidase	2019
Therapeutic Strategies for the Treatment of Chronic Hyperuricemia: An Evidence-Based Update. Medicina (Kaunas, Lithuania), 2021, Jan-10, Volume: 57, Issue:1 Topics: Acetamides; Allopurinol; Benzbromarone; Chronic Disease; Evidence-Based Medicine; Febuxostat; Gout Suppressants; Humans; Hyperuricemia; Naphthalenes; Nitriles; Phenylacetates; Polyethylene Glycols; Probenecid; Propionates; Pyridines; Thioglycolates; Triazoles; Urate Oxidase; Uricosuric Agents; Xanthine Oxidase	2021
Interventions for tophi in gout. The Cochrane database of systematic reviews, 2021, 08-11, Volume: 8 Topics: Allopurinol; Febuxostat; Gout; Gout Suppressants; Humans; Polyethylene Glycols; Randomized Controlled Trials as Topic; Thioglycolates; Triazoles; Urate Oxidase	2021

Trials

5 trial(s) available for triazoles and allopurinol

Article	Year
Lesinurad in combination with allopurinol: results of a phase 2, randomised, double-blind study in patients with gout with an inadequate response to allopurinol. Annals of the rheumatic diseases, 2016, Volume: 75, Issue:6 Topics: Adult; Allopurinol; Double-Blind Method; Drug Therapy, Combination; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Thioglycolates; Treatment Outcome; Triazoles	2016
Lesinurad Combined With Allopurinol: A Randomized, Double-Blind, Placebo-Controlled Study in Gout Patients With an Inadequate Response to Standard-of-Care Allopurinol (a US-Based Study). Arthritis & rheumatology (Hoboken, N.J.), 2017, Volume: 69, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Double-Blind Method; Drug Combinations; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Thioglycolates; Triazoles; United States; Uricosuric Agents; Young Adult	2017
Lesinurad in combination with allopurinol: a randomised, double-blind, placebo-controlled study in patients with gout with inadequate response to standard of care (the multinational CLEAR 2 study). Annals of the rheumatic diseases, 2017, Volume: 76, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Cardiovascular Diseases; Creatinine; Double-Blind Method; Drug Therapy, Combination; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Renal Insufficiency; Retreatment; Symptom Flare Up; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents; Young Adult	2017
Lesinurad monotherapy in gout patients intolerant to a xanthine oxidase inhibitor: a 6 month phase 3 clinical trial and extension study. Rheumatology (Oxford, England), 2017, 12-01, Volume: 56, Issue:12 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Double-Blind Method; Drug Resistance; Enzyme Inhibitors; Female; Gout; Humans; Male; Middle Aged; Thioglycolates; Treatment Outcome; Triazoles; Uricosuric Agents; Xanthine Oxidase; Young Adult	2017
The Effect of Lesinurad in Combination With Allopurinol on Serum Uric Acid Levels in Patients With Gout. Journal of clinical pharmacology, 2018, Volume: 58, Issue:9 Topics: Adult; Allopurinol; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Thioglycolates; Triazoles; Uric Acid	2018

Other Studies

50 other study(ies) available for triazoles and allopurinol

Article	Year
3,5-disubstituted 1,2,3,4-triazoles, 1 new class of xanthine oxidase inhibitor. Journal of medicinal chemistry, 1975, Volume: 18, Issue:9 Topics: Aerobiosis; Allantoin; Anaerobiosis; Animals; Dogs; Enterohepatic Circulation; Ferritins; Haplorhini; Hylobates; Hypoxanthines; Kinetics; Oxidation-Reduction; Polynucleotides; Rats; Saimiri; Species Specificity; Triazoles; Uric Acid; Xanthine Oxidase	1975
4-Trifluoromethylimidazoles and 5-(4-pyridyl)-1,2,4-triazoles, new classes of xanthine oxidase inhibitors. Journal of medicinal chemistry, 1975, Volume: 18, Issue:9 Topics: Animals; Cattle; Imidazoles; Kinetics; Pyridines; Structure-Activity Relationship; Triazoles; Xanthine Oxidase	1975
Inflammation and platelet-activating factor production during hepatic ischemia/reperfusion. Hepatology (Baltimore, Md.), 1992, Volume: 16, Issue:5 Topics: Alanine Transaminase; Allopurinol; Animals; Azepines; Gadolinium; Hepatitis; Ischemia; Leukocytes; Liver; Male; Necrosis; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Triazoles	1992
N-glucoside formation as a detoxification mechanism in mammals. The Journal of pharmacology and experimental therapeutics, 1974, Volume: 190, Issue:3 Topics: Aerobiosis; Animals; Bile; Biotransformation; Chromatography, Thin Layer; Dogs; Fluorescence; Glucosidases; Glucuronidase; Glycosides; Hydrogen-Ion Concentration; Hydrolysis; Hypoxanthines; Inactivation, Metabolic; Injections, Intravenous; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Molecular Conformation; Oxidation-Reduction; Pyridines; Pyrimidines; Spectrophotometry, Ultraviolet; Triazoles; Xanthine Oxidase	1974
Action of 8-azaguanine and 8-azaxanthine on Pseudomonas aeruginosa. The Biochemical journal, 1964, Volume: 91, Issue:2 Topics: Antimetabolites; Azaguanine; In Vitro Techniques; Pseudomonas aeruginosa; Triazoles; Uric Acid; Xanthine Oxidase; Xanthines	1964
Animal toxicity of 2,2,2-trifluoroethanol. Toxicology and applied pharmacology, 1969, Volume: 15, Issue:1 Topics: Acetates; Alcohol Oxidoreductases; Alcohols; Allopurinol; Animals; Carbon Isotopes; Disulfiram; Dogs; Ethanol; Fluoroacetates; Glucuronates; Hydrocarbons, Halogenated; In Vitro Techniques; Male; Mice; Triazoles; Yeasts	1969
In vitro susceptibility testing of Naegleria fowleri to ketoconazole, BAYn7133, and allopurinol riboside. The Journal of parasitology, 1984, Volume: 70, Issue:2 Topics: Allopurinol; Amoeba; Amphotericin B; Animals; Antiprotozoal Agents; Ketoconazole; Microbial Sensitivity Tests; Ribonucleosides; Triazoles	1984
Xanthine oxidase (XO). 4(5)-aminosubstituted-5(4)-carboxyamido-1H-1,2, 3-triazoles: a new class of monocyclic triazole inhibitors. Farmaco (Societa chimica italiana : 1989), 1995, Volume: 50, Issue:4 Topics: Molecular Structure; Triazoles; Xanthine Oxidase	1995
Molecular mechanisms involved in superoxide-induced leukocyte-endothelial cell interactions in vivo. The American journal of physiology, 1994, Volume: 266, Issue:2 Pt 2 Topics: Animals; Antibodies, Monoclonal; Antigens, CD; Azepines; Blood Pressure; Catalase; CD18 Antigens; Endothelium, Vascular; Free Radical Scavengers; Hypoxanthine; Hypoxanthines; Leukocytes; Male; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Receptors, Leukocyte-Adhesion; Splanchnic Circulation; Superoxides; Triazoles; Xanthine Oxidase	1994
Involvement of platelet-activating factor (PAF) in endotoxin- or ischaemia-induced intestinal hyperpermeability in the rat. Journal of lipid mediators, 1993, Volume: 7, Issue:1 Topics: Allopurinol; Animals; Azepines; Endotoxins; Free Radical Scavengers; Intestinal Mucosa; Intestines; Male; Permeability; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Thienopyridines; Triazoles; Xanthine Oxidase	1993
Superoxide modulates the oxidation and nitrosation of thiols by nitric oxide-derived reactive intermediates. Chemical aspects involved in the balance between oxidative and nitrosative stress. The Journal of biological chemistry, 1997, Apr-25, Volume: 272, Issue:17 Topics: Free Radicals; Glutathione; Glutathione Disulfide; Hydrazines; Models, Chemical; Nitrates; Nitric Oxide; Nitrogen Oxides; Nitroso Compounds; Oxidation-Reduction; S-Nitrosoglutathione; Sulfhydryl Compounds; Superoxides; Triazoles; Xanthine Oxidase	1997
Exogenous xanthine promotes neutrophil adherence to cultured endothelial cells. The American journal of physiology, 1997, Volume: 273, Issue:2 Pt 1 Topics: Antioxidants; Azepines; Cell Adhesion; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Heparin; Humans; Neutrophils; Osmolar Concentration; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles; Xanthine; Xanthine Oxidase; Xanthines	1997
Generation of sanazole nitro radicals by xanthine oxidase. Biochemistry. Biokhimiia, 1998, Volume: 63, Issue:12 Topics: Animals; Cattle; Nitro Compounds; Oxidation-Reduction; Radiation-Sensitizing Agents; Triazoles; Xanthine Oxidase	1998
Lucigenin luminescence elicited by microsomes and its modulation by nitroazole compounds. IUBMB life, 1999, Volume: 48, Issue:5 Topics: Acridines; Animals; Cattle; Horses; Luminescent Measurements; Male; Metronidazole; Microsomes, Liver; NADH, NADPH Oxidoreductases; NADP; Oxidation-Reduction; Radiation-Sensitizing Agents; Rats; Rats, Wistar; Superoxide Dismutase; Triazoles; Xanthine Oxidase	1999
Mechanisms for the induction of oxidative stress in Syrian hamster embryo cells by acrylonitrile. Toxicological sciences : an official journal of the Society of Toxicology, 2002, Volume: 67, Issue:2 Topics: Acrylonitrile; Animals; Carcinogens; Catalase; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Dose-Response Relationship, Drug; Drug Synergism; Embryo, Mammalian; Glutathione; Hydroxybenzoates; Hydroxyl Radical; Mesocricetus; Oxidative Stress; Reactive Oxygen Species; Superoxide Dismutase; Time Factors; Triazoles; Xanthine Oxidase	2002
Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors. British journal of pharmacology, 2009, Volume: 156, Issue:1 Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Allopurinol; Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Glutamic Acid; Hot Temperature; Injections, Intraperitoneal; Male; Mice; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pyrimidines; Triazoles; Uric Acid; Xanthine Oxidase; Xanthines	2009
Synthesis and biological activity of pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidin-4-one derivatives: in silico approach. Journal of enzyme inhibition and medicinal chemistry, 2010, Volume: 25, Issue:5 Topics: Computational Biology; Drug Design; Enzyme Inhibitors; Expert Systems; Gout Suppressants; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; Pyrimidinones; Spectrophotometry, Infrared; Thiazoles; Triazoles; Xanthine Oxidase	2010
Pre-clinical evaluation of a 3-nitro-1,2,4-triazole analogue of [18F]FMISO as hypoxia-selective tracer for PET. Nuclear medicine and biology, 2010, Volume: 37, Issue:5 Topics: Animals; Biomarkers; Cell Hypoxia; Cell Line, Tumor; Cell Transformation, Neoplastic; Chemical Phenomena; Drug Evaluation, Preclinical; Female; Glutathione; Kinetics; Mice; Misonidazole; Models, Biological; Neoplasms; Oxidation-Reduction; Positron-Emission Tomography; Propanols; Radioactive Tracers; Triazoles; Xanthine Oxidase	2010
Sitagliptin protects renal ischemia reperfusion induced renal damage in diabetes. Regulatory peptides, 2011, Jan-17, Volume: 166, Issue:1-3 Topics: Animals; Apoptosis; Catalase; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; DNA Fragmentation; Female; Glutathione; Glutathione Peroxidase; Kidney; Kidney Diseases; Lipid Peroxidation; Male; Oxidative Stress; Peroxidase; Pyrazines; Rats; Rats, Wistar; Reperfusion Injury; Sitagliptin Phosphate; Superoxide Dismutase; Triazoles; Xanthine Oxidase	2011
Supratherapeutic dose evaluation and effect of lesinurad on cardiac repolarization: a thorough QT/QTc study. Drug design, development and therapy, 2016, Volume: 10 Topics: Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Europe; Female; Heart Rate; Humans; Male; Statistics as Topic; Thioglycolates; Triazoles; Uric Acid; Xanthine Oxidase	2016
Reply. Arthritis & rheumatology (Hoboken, N.J.), 2017, Volume: 69, Issue:5 Topics: Allopurinol; Double-Blind Method; Gout; Humans; Thioglycolates; Triazoles	2017
Lesinurad in Combination With Allopurinol: Risk Without Reward? Comment on the Article by Saag et al. Arthritis & rheumatology (Hoboken, N.J.), 2017, Volume: 69, Issue:5 Topics: Allopurinol; Double-Blind Method; Gout; Humans; Reward; Thioglycolates; Triazoles	2017
Lesinurad combination therapy with allopurinol in gout: do CLEAR studies make the treatment of gout clearer? Annals of the rheumatic diseases, 2017, Volume: 76, Issue:5 Topics: Allopurinol; Double-Blind Method; Gout; Humans; Standard of Care; Thioglycolates; Triazoles	2017
Discovery and biological evaluation of some (1H-1,2,3-triazol-4-yl)methoxybenzaldehyde derivatives containing an anthraquinone moiety as potent xanthine oxidase inhibitors. Bioorganic & medicinal chemistry letters, 2017, 02-15, Volume: 27, Issue:4 Topics: Anthraquinones; Benzaldehydes; Binding Sites; Drug Evaluation, Preclinical; Enzyme Inhibitors; Inhibitory Concentration 50; Kinetics; Molecular Docking Simulation; Protein Binding; Protein Structure, Tertiary; Structure-Activity Relationship; Triazoles; Xanthine Oxidase	2017
Synthesis and evaluation of 1-phenyl-1H-1,2,3-triazole-4-carboxylic acid derivatives as xanthine oxidase inhibitors. Bioorganic & medicinal chemistry letters, 2017, 08-15, Volume: 27, Issue:16 Topics: Carboxylic Acids; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Triazoles; Xanthine Oxidase	2017
Impact of non-adherence on the safety and efficacy of uric acid-lowering therapies in the treatment of gout. British journal of clinical pharmacology, 2018, Volume: 84, Issue:1 Topics: Computer Simulation; Drug Therapy, Combination; Febuxostat; Gout; Gout Suppressants; Humans; Male; Medication Adherence; Models, Biological; Risk Assessment; Thioglycolates; Treatment Outcome; Triazoles; Uric Acid; Xanthine Oxidase	2018
Response to: 'A response to Singh. "Lesinurad combination therapy with allopurinol in gout: do CLEAR studies make the treatment of gout clearer?"' by Valiyil and Schechter. Annals of the rheumatic diseases, 2018, Volume: 77, Issue:7 Topics: Allopurinol; Double-Blind Method; Gout; Humans; Standard of Care; Thioglycolates; Triazoles	2018
Lesinurad combination therapy with allopurinol in gout: do CLEAR studies make the treatment of gout clearer? Annals of the rheumatic diseases, 2018, Volume: 77, Issue:7 Topics: Allopurinol; Double-Blind Method; Gout; Humans; Standard of Care; Thioglycolates; Triazoles	2018
Lesinurad/Allopurinol (Duzallo) for Gout-Associated Hyperuricemia. JAMA, 2018, 01-09, Volume: 319, Issue:2 Topics: Allopurinol; Drug Combinations; Drug Interactions; Gout; Gout Suppressants; Humans; Hyperuricemia; Organic Anion Transporters; Organic Cation Transport Proteins; Thioglycolates; Triazoles; Xanthine Oxidase	2018
Individualized treatment strategies for hyperuricemia informed by a semi-mechanistic exposure-response model of uric acid dynamics. Physiological reports, 2018, Volume: 6, Issue:5 Topics: Allopurinol; Clinical Trials as Topic; Febuxostat; Humans; Hyperuricemia; Models, Theoretical; Precision Medicine; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents	2018
Chronic Disease Approaches Needed to Curb Gout's Growing Burden. JAMA, 2018, Apr-03, Volume: 319, Issue:13 Topics: Allopurinol; Chronic Disease; Diet; Drug Combinations; Febuxostat; Gout; Gout Suppressants; Healthy Lifestyle; Humans; Patient Education as Topic; Practice Guidelines as Topic; Purines; Thioglycolates; Triazoles; Uric Acid	2018
Cost-Effectiveness Analysis of Lesinurad/Allopurinol Versus Febuxostat for the Management of Gout/Hyperuricemia in Italy. PharmacoEconomics, 2018, Volume: 36, Issue:5 Topics: Allopurinol; Cost-Benefit Analysis; Drug Costs; Drug Therapy, Combination; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Italy; Male; Markov Chains; Middle Aged; Models, Economic; Monte Carlo Method; Quality-Adjusted Life Years; Thioglycolates; Triazoles	2018
Budget impact of adding lesinurad for second-line treatment of gout: a US health plan perspective. Journal of comparative effectiveness research, 2018, Volume: 7, Issue:8 Topics: Allopurinol; Budgets; Gout; Gout Suppressants; Humans; Markov Chains; Models, Econometric; Thioglycolates; Triazoles; United States	2018
Integrated safety studies of the urate reabsorption inhibitor lesinurad in treatment of gout. Rheumatology (Oxford, England), 2019, 01-01, Volume: 58, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Clinical Trials, Phase III as Topic; Drug Therapy, Combination; Enzyme Inhibitors; Female; Gout; Gout Suppressants; Humans; Kidney Diseases; Male; Middle Aged; Randomized Controlled Trials as Topic; Thioglycolates; Treatment Outcome; Triazoles; Uric Acid; Xanthine Oxidase; Young Adult	2019
Impact of Non-Adherence and Flare Resolution on the Cost-Effectiveness of Treatments for Gout: Application of a Linked Pharmacometric/Pharmacoeconomic Model. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 2018, Volume: 21, Issue:12 Topics: Allopurinol; Cohort Studies; Cost-Benefit Analysis; Drug Therapy, Combination; Economics, Pharmaceutical; Febuxostat; Gout; Gout Suppressants; Health Care Costs; Humans; Medication Adherence; Models, Biological; Models, Economic; Quality of Life; Quality-Adjusted Life Years; Thioglycolates; Treatment Outcome; Triazoles; United Kingdom; Uric Acid	2018
Ultra-performance hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry for simultaneous determination of allopurinol, oxypurinol and lesinurad in rat plasma: Application to pharmacokinetic study in rats. PloS one, 2019, Volume: 14, Issue:3 Topics: Allopurinol; Animals; Chromatography, Liquid; Hydrophobic and Hydrophilic Interactions; Oxypurinol; Rats; Reproducibility of Results; Tandem Mass Spectrometry; Thioglycolates; Tissue Distribution; Triazoles	2019
Synthesis and Biological Evaluation of 5-benzyl-3-pyridyl-1H-1,2,4-triazole Derivatives as Xanthine Oxidase Inhibitors. Medicinal chemistry (Shariqah (United Arab Emirates)), 2020, Volume: 16, Issue:1 Topics: Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Molecular Structure; Structure-Activity Relationship; Triazoles; Xanthine Oxidase	2020
Genomic signatures defining responsiveness to allopurinol and combination therapy for lung cancer identified by systems therapeutics analyses. Molecular oncology, 2019, Volume: 13, Issue:8 Topics: Allopurinol; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genomics; Humans; Janus Kinase 2; Lung Neoplasms; Mice, Nude; Phenotype; Protein Kinase Inhibitors; Pyridines; Systems Analysis; Triazoles; Xenograft Model Antitumor Assays	2019
Second-line treatment with lesinurad and allopurinol versus febuxostat for management of hyperuricemia: a cost-effectiveness analysis for Spanish patients. Clinical rheumatology, 2019, Volume: 38, Issue:12 Topics: Allopurinol; Cost-Benefit Analysis; Febuxostat; Gout Suppressants; Humans; Hyperuricemia; Markov Chains; Spain; Thioglycolates; Triazoles	2019
The Effects of Special Patient Population Plasma on Pharmacokinetic Quantifications Using LC-MS/MS. Drug metabolism letters, 2019, Volume: 13, Issue:2 Topics: Allopurinol; Calibration; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Hepatic Insufficiency; Humans; Kidney; Liver; Oxypurinol; Reference Standards; Renal Insufficiency; Renal Reabsorption; Reproducibility of Results; Tandem Mass Spectrometry; Thioglycolates; Triazoles; Uricosuric Agents; Verapamil	2019
Impact of Lesinurad and allopurinol on experimental Hyperuricemia in mice: biochemical, molecular and Immunohistochemical study. BMC pharmacology & toxicology, 2020, 02-10, Volume: 21, Issue:1 Topics: Allopurinol; Animals; Blood Urea Nitrogen; Catalase; Drug Synergism; Glutathione Peroxidase; Gout Suppressants; Hyperuricemia; Interleukin-1beta; Kidney; Liver; Male; Mice; Thioglycolates; Triazoles; Tumor Necrosis Factor-alpha; Uric Acid; Xanthine Oxidase	2020
Application of different spectrofluorimetric methods for determination of lesinurad and allopurinol in pharmaceutical preparation and human plasma. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2021, Jan-05, Volume: 244 Topics: Allopurinol; Calibration; Humans; Spectrometry, Fluorescence; Thioglycolates; Triazoles	2021
Trends in Utilization of Urate-Lowering Therapies Following the US Food and Drug Administration's Boxed Warning on Febuxostat. Arthritis & rheumatology (Hoboken, N.J.), 2021, Volume: 73, Issue:3 Topics: Allopurinol; Cardiovascular Diseases; Cause of Death; Drug Labeling; Febuxostat; Gout; Gout Suppressants; Humans; Mortality; Polyethylene Glycols; Practice Patterns, Physicians'; Probenecid; Risk Factors; Thioglycolates; Triazoles; United States; United States Food and Drug Administration; Urate Oxidase	2021
Spectrophotometric determination of lesinurad and allopurinol in recently approved FDA pharmaceutical preparation. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2021, Feb-15, Volume: 247 Topics: Allopurinol; Spectrophotometry; Thioglycolates; Triazoles	2021
Different chemometric assisted approaches for spectrophotometric quantitative analysis of lesinurad and allopurinol. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2021, Apr-15, Volume: 251 Topics: Allopurinol; Least-Squares Analysis; Spectrophotometry; Thioglycolates; Triazoles	2021
Synthesis, inhibition properties against xanthine oxidase and molecular docking studies of dimethyl N-benzyl-1H-1,2,3-triazole-4,5-dicarboxylate and (N-benzyl-1H-1,2,3-triazole-4,5-diyl)dimethanol derivatives. Bioorganic chemistry, 2021, Volume: 108 Topics: Animals; Cattle; Dose-Response Relationship, Drug; Enzyme Inhibitors; Milk; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Triazoles; Xanthine Oxidase	2021
Discovery of 4-(phenoxymethyl)-1H-1,2,3-triazole derivatives as novel xanthine oxidase inhibitors. Bioorganic & medicinal chemistry letters, 2022, 03-15, Volume: 60 Topics: Animals; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Hyperuricemia; Ligands; Models, Molecular; Molecular Structure; Oxonic Acid; Rats; Structure-Activity Relationship; Triazoles; Uric Acid; Xanthine Oxidase	2022
Design, synthesis, and biological evaluation of isatin-indole-3-carboxaldehyde hybrids as a new class of xanthine oxidase inhibitors. Archiv der Pharmazie, 2022, Volume: 355, Issue:6 Topics: Enzyme Inhibitors; Indoles; Isatin; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Triazoles; Xanthine Oxidase	2022
Different spectrophotometric methods for simultaneous determination of lesinurad and allopurinol in the new FDA approved pharmaceutical preparation; additional greenness evaluation. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2023, Jan-15, Volume: 285 Topics: Allopurinol; Gout; Gout Suppressants; Humans; Triazoles	2023
Discovery of novel 1,2,4-triazole derivatives as xanthine oxidoreductase inhibitors with hypouricemic effects. Bioorganic chemistry, 2022, Volume: 129 Topics: Animals; Enzyme Inhibitors; Febuxostat; Gout; Hyperuricemia; Mice; Triazoles; Xanthine Dehydrogenase; Xanthine Oxidase	2022