triazoles has been researched along with allopurinol in 66 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 6 (9.09) | 18.7374 |
1990's | 8 (12.12) | 18.2507 |
2000's | 2 (3.03) | 29.6817 |
2010's | 37 (56.06) | 24.3611 |
2020's | 13 (19.70) | 2.80 |
Authors | Studies |
---|---|
Baer, JE; Baldwin, JJ; Duggan, DE; Noll, RM; Novello, FC | 1 |
Baldwin, JJ; Duggan, DE; Kasinger, PA; Novello, FC; Sprague, JM | 1 |
Levine, BA; McCollum, MO; Olson, MS; Zhou, W | 1 |
Arison, BH; Baldwin, JJ; Duggan, DE; Rhodes, RE | 1 |
Bergmann, F; Kwietny-Govrin, H; Ungar-Waron, H | 1 |
Blake, DA; Cascorbi, HF; Meyer, FJ; Rozman, RS | 1 |
Durack, DT; Smego, RA | 1 |
Biagi, G; Costantino, L; Giorgi, I; Livi, O; Scartoni, V; Tonetti, I | 1 |
Anderson, DC; Gaboury, JP; Kubes, P | 1 |
Baroggi, N; Braquet, P; Defaux, JP; Etienne, A; Thonier, F | 1 |
Cook, JA; Grisham, MB; Jourd'heuil, D; Kim, SY; Krishna, MC; Miles, AM; Mitchell, JB; Pacelli, R; Russo, A; Vodovotz, Y; Wink, DA | 1 |
Alexander, JS; Aw, TY; Coe, L; Granger, DN; Ichikawa, H; Ohno, N; Wolf, RE; Yoshikawa, T | 1 |
Shchepetkin, IA | 1 |
Schepetkin, IA | 1 |
Kamendulis, LM; Klaunig, JE; Zhang, H | 1 |
Antunes, C; Böhmer, AE; Elisabetsky, E; Lara, DR; Porciúncula, LO; Schallenberger, C; Schmidt, AP; Souza, DO | 1 |
Bodade, RG; Dawane, BS; Khandare, NT; Khobragade, CN; Konda, SG | 1 |
Ball, C; Bejot, R; Carroll, L; Elizarov, AM; Gouverneur, V; Hill, S; Kelly, C; Kersemans, V; King, RC; Kolb, HC; Miraghaie, R; Smart, S; Zhang, J | 1 |
Bhalodia, Y; Manek, R; Sheth, N; Vaghasiya, J | 1 |
Cravets, M; Miner, JN; Perez-Ruiz, F; Storgard, C; Sundy, JS | 1 |
Hoy, SM | 1 |
Adler, S; Baumgartner, S; Becker, MA; Bhakta, N; Fitz-Patrick, D; Fung, M; Kopicko, J; Saag, KG; Storgard, C | 1 |
Adler, S; Bardin, T; Baumgartner, S; Bhakta, N; Fung, M; Keenan, RT; Khanna, PP; Kopicko, J; So, A; Storgard, C | 1 |
Gillen, M; Harmon, E; Kerr, B; Lee, CA; Nguyen, M; Shen, Z; Tieu, K; Wilson, DM | 1 |
Saag, KG | 1 |
Abeles, AM | 1 |
Singh, JA | 2 |
Li, SY; Meng, FH; Sun, Q; Wang, L; Wu, QX; Yang, S; Yuan, WY; Zhang, TJ | 1 |
Deeks, ED | 1 |
Gao, H; Li, SY; Meng, FH; Sun, Q; Wang, L; Wu, QX; Zhang, TJ; Zhang, Y | 1 |
Hill-McManus, D; Hughes, D; Lane, S; Marshall, S; Soto, E | 2 |
Schechter, B; Valiyil, R | 1 |
Adler, S; Alten, R; Baumgartner, S; Bhakta, N; Dalbeth, N; Fung, M; Kopicko, J; Saag, K; Storgard, C; Tausche, AK | 1 |
Aksenov, S; Eriksson, UG; Peck, CC; Stanski, DR | 1 |
Kuehn, BM | 1 |
Basile, M; Cicchetti, A; Drago, C; Rolli, FR; Ruggeri, M | 1 |
Baumgartner, S; Kerr, B; Manhard, K; Quart, B; Shen, Z; Yeh, LT | 1 |
Bly, CA; Cinfio, FN; Kabadi, S; Klein, RW; Szymanski, KA; Taylor, DC | 1 |
Baumgartner, S; Goldfarb, DS; Jalal, D; Pillinger, M; Saag, KG; Schechter, BM; Terkeltaub, R; Valiyil, R; White, WB | 1 |
Jansen, TL; Perez-Ruiz, F; Richette, P; Tausche, AK | 1 |
Robinson, PC | 1 |
Fields, TR | 1 |
Bartsch, LA; Castillo-Rodriguez, E; Fernandez-Prado, R; Kanbay, M; Ortiz, A; Perez-Gomez, MV | 1 |
Gupta, MK; Singh, JA | 1 |
Alam, O; Ezzeldin, E; Herqash, RN; Iqbal, M | 1 |
Li, SY; Meng, FH; Olounfeh, KM; Wu, QX; Zhang, TJ; Zhang, Y | 1 |
Lee, YH; Song, GG | 1 |
Boran, A; Chen, Y; Gallo, J; Goldfarb, J; Hu, Y; Iyengar, R; Jayaraman, G; Li, L; Mariottini, C; Tavassoly, I; Tolentino, RE; Zhao, S | 1 |
Oyagüez, I; Pérez-Ruiz, F; Presa, M | 1 |
Nguyen, M; Sun, L; Wilson, DM; Yeh, LT; Zhou, D | 1 |
Alghamdi, YS; Nassan, MA; Soliman, MM | 1 |
Abdelazim, AH; Attia, KAM; El-Olemy, A; Hasan, MA; Omar, MKM; Ramzy, S; Shahin, M | 1 |
Desai, RJ; Kim, E; Kim, SC; Lii, J; Neogi, T | 1 |
Abdelazim, AH; El-Olemy, A; Mohamed, AA; Omar, MKM; Ramzy, S; Shahin, M | 1 |
Borghi, C; Cicero, AFG; Fogacci, F; Kuwabara, M | 1 |
Abdelazim, AH; Shahin, M | 1 |
Al-Khafaji, K; Altundas, A; Ates, B; Noma, SAA; Taskin-Tok, T; Yagiz, G | 1 |
Bombardier, C; Edwards, CJ; Pardo Pardo, J; Sriranganathan, MK; Vinik, O | 1 |
Guo, S; Hu, SS; Lu, PF; Meng, FH; Wang, ZR; Zhang, TJ; Zhang, X; Zhang, Y; Zhang, ZH | 1 |
Bedi, PMS; Bhagat, K; Chadha, R; Gulati, HK; Heer, S; Kaur, G; Kaur, K; Kumar, N; Sharma, A; Singh, A; Singh, H; Singh, JV | 1 |
Abd Elhalim, LM; Abdelazim, AH; Abourehab, MAS; Almrasy, AA; Ramzy, S | 1 |
Cheng, H; Hou, X; Li, X; Nan, G; Ren, L; Tian, J; Xiao, Z; Yan, D; Yang, Y; Ye, F | 1 |
11 review(s) available for triazoles and allopurinol
Article | Year |
---|---|
Lesinurad: First Global Approval.
Topics: Clinical Trials as Topic; Enzyme Inhibitors; Gout; Humans; Hyperuricemia; Thioglycolates; Triazoles; Uricosuric Agents; Xanthine Oxidase | 2016 |
Lesinurad (Zurampic) for gout-associated hyperuricemia.
Topics: Clinical Trials as Topic; Gout; Humans; Hyperuricemia; Thioglycolates; Triazoles; Uricosuric Agents; Xanthine Oxidase | 2016 |
Lesinurad: A Review in Hyperuricaemia of Gout.
Topics: Adult; Allopurinol; Drug Therapy, Combination; Enzyme Inhibitors; Febuxostat; Gout; Humans; Hyperuricemia; Kidney; Middle Aged; Organic Anion Transporters; Organic Cation Transport Proteins; Thioglycolates; Treatment Outcome; Triazoles; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2017 |
International position paper on the appropriate use of uricosurics with the introduction of lesinurad.
Topics: Benzbromarone; Europe; Febuxostat; Gout; Humans; International Cooperation; Practice Guidelines as Topic; Probenecid; Rheumatology; Thioglycolates; Triazoles; Uricosuric Agents; Xanthine Oxidase | 2018 |
Gout - An update of aetiology, genetics, co-morbidities and management.
Topics: Allopurinol; Chronic Disease; Comorbidity; Diet; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Probenecid; Thioglycolates; Triazoles; Uric Acid | 2018 |
The Challenges of Approaching and Managing Gout.
Topics: Acetamides; Allopurinol; Antibodies, Monoclonal, Humanized; Colchicine; Diet Therapy; Febuxostat; Gout; Gout Suppressants; Humans; Medication Adherence; Patient Education as Topic; Phenylacetates; Polyethylene Glycols; Quality of Health Care; Rheumatology; Thioglycolates; Triazoles; Urate Oxidase; Uric Acid | 2019 |
Potential Dangers of Serum Urate-Lowering Therapy.
Topics: Cardiovascular Diseases; Gout Suppressants; Humans; Oxidative Stress; Polyethylene Glycols; Thioglycolates; Triazoles; Urate Oxidase; Uric Acid; Xanthine Oxidase | 2019 |
Cardiovascular Disease in Gout and the Protective Effect of Treatments Including Urate-Lowering Therapy.
Topics: Allopurinol; Anti-Inflammatory Agents; Cardiovascular Diseases; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Thioglycolates; Treatment Outcome; Triazoles; Uric Acid | 2019 |
Comparative efficacy and safety of lesinurad 200 mg and 400 mg combined with a xanthine oxidase inhibitor in hyperuricemic patients with gout: A Bayesian network meta-analysis of randomized controlled trials
.
Topics: Bayes Theorem; Drug Therapy, Combination; Gout; Humans; Network Meta-Analysis; Randomized Controlled Trials as Topic; Thioglycolates; Triazoles; Uric Acid; Xanthine Oxidase | 2019 |
Therapeutic Strategies for the Treatment of Chronic Hyperuricemia: An Evidence-Based Update.
Topics: Acetamides; Allopurinol; Benzbromarone; Chronic Disease; Evidence-Based Medicine; Febuxostat; Gout Suppressants; Humans; Hyperuricemia; Naphthalenes; Nitriles; Phenylacetates; Polyethylene Glycols; Probenecid; Propionates; Pyridines; Thioglycolates; Triazoles; Urate Oxidase; Uricosuric Agents; Xanthine Oxidase | 2021 |
Interventions for tophi in gout.
Topics: Allopurinol; Febuxostat; Gout; Gout Suppressants; Humans; Polyethylene Glycols; Randomized Controlled Trials as Topic; Thioglycolates; Triazoles; Urate Oxidase | 2021 |
5 trial(s) available for triazoles and allopurinol
Article | Year |
---|---|
Lesinurad in combination with allopurinol: results of a phase 2, randomised, double-blind study in patients with gout with an inadequate response to allopurinol.
Topics: Adult; Allopurinol; Double-Blind Method; Drug Therapy, Combination; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Thioglycolates; Treatment Outcome; Triazoles | 2016 |
Lesinurad Combined With Allopurinol: A Randomized, Double-Blind, Placebo-Controlled Study in Gout Patients With an Inadequate Response to Standard-of-Care Allopurinol (a US-Based Study).
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Double-Blind Method; Drug Combinations; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Thioglycolates; Triazoles; United States; Uricosuric Agents; Young Adult | 2017 |
Lesinurad in combination with allopurinol: a randomised, double-blind, placebo-controlled study in patients with gout with inadequate response to standard of care (the multinational CLEAR 2 study).
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Cardiovascular Diseases; Creatinine; Double-Blind Method; Drug Therapy, Combination; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Renal Insufficiency; Retreatment; Symptom Flare Up; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents; Young Adult | 2017 |
Lesinurad monotherapy in gout patients intolerant to a xanthine oxidase inhibitor: a 6 month phase 3 clinical trial and extension study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Double-Blind Method; Drug Resistance; Enzyme Inhibitors; Female; Gout; Humans; Male; Middle Aged; Thioglycolates; Treatment Outcome; Triazoles; Uricosuric Agents; Xanthine Oxidase; Young Adult | 2017 |
The Effect of Lesinurad in Combination With Allopurinol on Serum Uric Acid Levels in Patients With Gout.
Topics: Adult; Allopurinol; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Thioglycolates; Triazoles; Uric Acid | 2018 |
50 other study(ies) available for triazoles and allopurinol
Article | Year |
---|---|
3,5-disubstituted 1,2,3,4-triazoles, 1 new class of xanthine oxidase inhibitor.
Topics: Aerobiosis; Allantoin; Anaerobiosis; Animals; Dogs; Enterohepatic Circulation; Ferritins; Haplorhini; Hylobates; Hypoxanthines; Kinetics; Oxidation-Reduction; Polynucleotides; Rats; Saimiri; Species Specificity; Triazoles; Uric Acid; Xanthine Oxidase | 1975 |
4-Trifluoromethylimidazoles and 5-(4-pyridyl)-1,2,4-triazoles, new classes of xanthine oxidase inhibitors.
Topics: Animals; Cattle; Imidazoles; Kinetics; Pyridines; Structure-Activity Relationship; Triazoles; Xanthine Oxidase | 1975 |
Inflammation and platelet-activating factor production during hepatic ischemia/reperfusion.
Topics: Alanine Transaminase; Allopurinol; Animals; Azepines; Gadolinium; Hepatitis; Ischemia; Leukocytes; Liver; Male; Necrosis; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Triazoles | 1992 |
N-glucoside formation as a detoxification mechanism in mammals.
Topics: Aerobiosis; Animals; Bile; Biotransformation; Chromatography, Thin Layer; Dogs; Fluorescence; Glucosidases; Glucuronidase; Glycosides; Hydrogen-Ion Concentration; Hydrolysis; Hypoxanthines; Inactivation, Metabolic; Injections, Intravenous; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Molecular Conformation; Oxidation-Reduction; Pyridines; Pyrimidines; Spectrophotometry, Ultraviolet; Triazoles; Xanthine Oxidase | 1974 |
Action of 8-azaguanine and 8-azaxanthine on Pseudomonas aeruginosa.
Topics: Antimetabolites; Azaguanine; In Vitro Techniques; Pseudomonas aeruginosa; Triazoles; Uric Acid; Xanthine Oxidase; Xanthines | 1964 |
Animal toxicity of 2,2,2-trifluoroethanol.
Topics: Acetates; Alcohol Oxidoreductases; Alcohols; Allopurinol; Animals; Carbon Isotopes; Disulfiram; Dogs; Ethanol; Fluoroacetates; Glucuronates; Hydrocarbons, Halogenated; In Vitro Techniques; Male; Mice; Triazoles; Yeasts | 1969 |
In vitro susceptibility testing of Naegleria fowleri to ketoconazole, BAYn7133, and allopurinol riboside.
Topics: Allopurinol; Amoeba; Amphotericin B; Animals; Antiprotozoal Agents; Ketoconazole; Microbial Sensitivity Tests; Ribonucleosides; Triazoles | 1984 |
Xanthine oxidase (XO). 4(5)-aminosubstituted-5(4)-carboxyamido-1H-1,2, 3-triazoles: a new class of monocyclic triazole inhibitors.
Topics: Molecular Structure; Triazoles; Xanthine Oxidase | 1995 |
Molecular mechanisms involved in superoxide-induced leukocyte-endothelial cell interactions in vivo.
Topics: Animals; Antibodies, Monoclonal; Antigens, CD; Azepines; Blood Pressure; Catalase; CD18 Antigens; Endothelium, Vascular; Free Radical Scavengers; Hypoxanthine; Hypoxanthines; Leukocytes; Male; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Receptors, Leukocyte-Adhesion; Splanchnic Circulation; Superoxides; Triazoles; Xanthine Oxidase | 1994 |
Involvement of platelet-activating factor (PAF) in endotoxin- or ischaemia-induced intestinal hyperpermeability in the rat.
Topics: Allopurinol; Animals; Azepines; Endotoxins; Free Radical Scavengers; Intestinal Mucosa; Intestines; Male; Permeability; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Thienopyridines; Triazoles; Xanthine Oxidase | 1993 |
Superoxide modulates the oxidation and nitrosation of thiols by nitric oxide-derived reactive intermediates. Chemical aspects involved in the balance between oxidative and nitrosative stress.
Topics: Free Radicals; Glutathione; Glutathione Disulfide; Hydrazines; Models, Chemical; Nitrates; Nitric Oxide; Nitrogen Oxides; Nitroso Compounds; Oxidation-Reduction; S-Nitrosoglutathione; Sulfhydryl Compounds; Superoxides; Triazoles; Xanthine Oxidase | 1997 |
Exogenous xanthine promotes neutrophil adherence to cultured endothelial cells.
Topics: Antioxidants; Azepines; Cell Adhesion; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Heparin; Humans; Neutrophils; Osmolar Concentration; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles; Xanthine; Xanthine Oxidase; Xanthines | 1997 |
Generation of sanazole nitro radicals by xanthine oxidase.
Topics: Animals; Cattle; Nitro Compounds; Oxidation-Reduction; Radiation-Sensitizing Agents; Triazoles; Xanthine Oxidase | 1998 |
Lucigenin luminescence elicited by microsomes and its modulation by nitroazole compounds.
Topics: Acridines; Animals; Cattle; Horses; Luminescent Measurements; Male; Metronidazole; Microsomes, Liver; NADH, NADPH Oxidoreductases; NADP; Oxidation-Reduction; Radiation-Sensitizing Agents; Rats; Rats, Wistar; Superoxide Dismutase; Triazoles; Xanthine Oxidase | 1999 |
Mechanisms for the induction of oxidative stress in Syrian hamster embryo cells by acrylonitrile.
Topics: Acrylonitrile; Animals; Carcinogens; Catalase; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Dose-Response Relationship, Drug; Drug Synergism; Embryo, Mammalian; Glutathione; Hydroxybenzoates; Hydroxyl Radical; Mesocricetus; Oxidative Stress; Reactive Oxygen Species; Superoxide Dismutase; Time Factors; Triazoles; Xanthine Oxidase | 2002 |
Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Allopurinol; Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Glutamic Acid; Hot Temperature; Injections, Intraperitoneal; Male; Mice; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pyrimidines; Triazoles; Uric Acid; Xanthine Oxidase; Xanthines | 2009 |
Synthesis and biological activity of pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidin-4-one derivatives: in silico approach.
Topics: Computational Biology; Drug Design; Enzyme Inhibitors; Expert Systems; Gout Suppressants; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; Pyrimidinones; Spectrophotometry, Infrared; Thiazoles; Triazoles; Xanthine Oxidase | 2010 |
Pre-clinical evaluation of a 3-nitro-1,2,4-triazole analogue of [18F]FMISO as hypoxia-selective tracer for PET.
Topics: Animals; Biomarkers; Cell Hypoxia; Cell Line, Tumor; Cell Transformation, Neoplastic; Chemical Phenomena; Drug Evaluation, Preclinical; Female; Glutathione; Kinetics; Mice; Misonidazole; Models, Biological; Neoplasms; Oxidation-Reduction; Positron-Emission Tomography; Propanols; Radioactive Tracers; Triazoles; Xanthine Oxidase | 2010 |
Sitagliptin protects renal ischemia reperfusion induced renal damage in diabetes.
Topics: Animals; Apoptosis; Catalase; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; DNA Fragmentation; Female; Glutathione; Glutathione Peroxidase; Kidney; Kidney Diseases; Lipid Peroxidation; Male; Oxidative Stress; Peroxidase; Pyrazines; Rats; Rats, Wistar; Reperfusion Injury; Sitagliptin Phosphate; Superoxide Dismutase; Triazoles; Xanthine Oxidase | 2011 |
Supratherapeutic dose evaluation and effect of lesinurad on cardiac repolarization: a thorough QT/QTc study.
Topics: Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Europe; Female; Heart Rate; Humans; Male; Statistics as Topic; Thioglycolates; Triazoles; Uric Acid; Xanthine Oxidase | 2016 |
Reply.
Topics: Allopurinol; Double-Blind Method; Gout; Humans; Thioglycolates; Triazoles | 2017 |
Lesinurad in Combination With Allopurinol: Risk Without Reward? Comment on the Article by Saag et al.
Topics: Allopurinol; Double-Blind Method; Gout; Humans; Reward; Thioglycolates; Triazoles | 2017 |
Lesinurad combination therapy with allopurinol in gout: do CLEAR studies make the treatment of gout clearer?
Topics: Allopurinol; Double-Blind Method; Gout; Humans; Standard of Care; Thioglycolates; Triazoles | 2017 |
Discovery and biological evaluation of some (1H-1,2,3-triazol-4-yl)methoxybenzaldehyde derivatives containing an anthraquinone moiety as potent xanthine oxidase inhibitors.
Topics: Anthraquinones; Benzaldehydes; Binding Sites; Drug Evaluation, Preclinical; Enzyme Inhibitors; Inhibitory Concentration 50; Kinetics; Molecular Docking Simulation; Protein Binding; Protein Structure, Tertiary; Structure-Activity Relationship; Triazoles; Xanthine Oxidase | 2017 |
Synthesis and evaluation of 1-phenyl-1H-1,2,3-triazole-4-carboxylic acid derivatives as xanthine oxidase inhibitors.
Topics: Carboxylic Acids; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Triazoles; Xanthine Oxidase | 2017 |
Impact of non-adherence on the safety and efficacy of uric acid-lowering therapies in the treatment of gout.
Topics: Computer Simulation; Drug Therapy, Combination; Febuxostat; Gout; Gout Suppressants; Humans; Male; Medication Adherence; Models, Biological; Risk Assessment; Thioglycolates; Treatment Outcome; Triazoles; Uric Acid; Xanthine Oxidase | 2018 |
Response to: 'A response to Singh. "Lesinurad combination therapy with allopurinol in gout: do CLEAR studies make the treatment of gout clearer?"' by Valiyil and Schechter.
Topics: Allopurinol; Double-Blind Method; Gout; Humans; Standard of Care; Thioglycolates; Triazoles | 2018 |
Lesinurad combination therapy with allopurinol in gout: do CLEAR studies make the treatment of gout clearer?
Topics: Allopurinol; Double-Blind Method; Gout; Humans; Standard of Care; Thioglycolates; Triazoles | 2018 |
Lesinurad/Allopurinol (Duzallo) for Gout-Associated Hyperuricemia.
Topics: Allopurinol; Drug Combinations; Drug Interactions; Gout; Gout Suppressants; Humans; Hyperuricemia; Organic Anion Transporters; Organic Cation Transport Proteins; Thioglycolates; Triazoles; Xanthine Oxidase | 2018 |
Individualized treatment strategies for hyperuricemia informed by a semi-mechanistic exposure-response model of uric acid dynamics.
Topics: Allopurinol; Clinical Trials as Topic; Febuxostat; Humans; Hyperuricemia; Models, Theoretical; Precision Medicine; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents | 2018 |
Chronic Disease Approaches Needed to Curb Gout's Growing Burden.
Topics: Allopurinol; Chronic Disease; Diet; Drug Combinations; Febuxostat; Gout; Gout Suppressants; Healthy Lifestyle; Humans; Patient Education as Topic; Practice Guidelines as Topic; Purines; Thioglycolates; Triazoles; Uric Acid | 2018 |
Cost-Effectiveness Analysis of Lesinurad/Allopurinol Versus Febuxostat for the Management of Gout/Hyperuricemia in Italy.
Topics: Allopurinol; Cost-Benefit Analysis; Drug Costs; Drug Therapy, Combination; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Italy; Male; Markov Chains; Middle Aged; Models, Economic; Monte Carlo Method; Quality-Adjusted Life Years; Thioglycolates; Triazoles | 2018 |
Budget impact of adding lesinurad for second-line treatment of gout: a US health plan perspective.
Topics: Allopurinol; Budgets; Gout; Gout Suppressants; Humans; Markov Chains; Models, Econometric; Thioglycolates; Triazoles; United States | 2018 |
Integrated safety studies of the urate reabsorption inhibitor lesinurad in treatment of gout.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Clinical Trials, Phase III as Topic; Drug Therapy, Combination; Enzyme Inhibitors; Female; Gout; Gout Suppressants; Humans; Kidney Diseases; Male; Middle Aged; Randomized Controlled Trials as Topic; Thioglycolates; Treatment Outcome; Triazoles; Uric Acid; Xanthine Oxidase; Young Adult | 2019 |
Impact of Non-Adherence and Flare Resolution on the Cost-Effectiveness of Treatments for Gout: Application of a Linked Pharmacometric/Pharmacoeconomic Model.
Topics: Allopurinol; Cohort Studies; Cost-Benefit Analysis; Drug Therapy, Combination; Economics, Pharmaceutical; Febuxostat; Gout; Gout Suppressants; Health Care Costs; Humans; Medication Adherence; Models, Biological; Models, Economic; Quality of Life; Quality-Adjusted Life Years; Thioglycolates; Treatment Outcome; Triazoles; United Kingdom; Uric Acid | 2018 |
Ultra-performance hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry for simultaneous determination of allopurinol, oxypurinol and lesinurad in rat plasma: Application to pharmacokinetic study in rats.
Topics: Allopurinol; Animals; Chromatography, Liquid; Hydrophobic and Hydrophilic Interactions; Oxypurinol; Rats; Reproducibility of Results; Tandem Mass Spectrometry; Thioglycolates; Tissue Distribution; Triazoles | 2019 |
Synthesis and Biological Evaluation of 5-benzyl-3-pyridyl-1H-1,2,4-triazole Derivatives as Xanthine Oxidase Inhibitors.
Topics: Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Molecular Structure; Structure-Activity Relationship; Triazoles; Xanthine Oxidase | 2020 |
Genomic signatures defining responsiveness to allopurinol and combination therapy for lung cancer identified by systems therapeutics analyses.
Topics: Allopurinol; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genomics; Humans; Janus Kinase 2; Lung Neoplasms; Mice, Nude; Phenotype; Protein Kinase Inhibitors; Pyridines; Systems Analysis; Triazoles; Xenograft Model Antitumor Assays | 2019 |
Second-line treatment with lesinurad and allopurinol versus febuxostat for management of hyperuricemia: a cost-effectiveness analysis for Spanish patients.
Topics: Allopurinol; Cost-Benefit Analysis; Febuxostat; Gout Suppressants; Humans; Hyperuricemia; Markov Chains; Spain; Thioglycolates; Triazoles | 2019 |
The Effects of Special Patient Population Plasma on Pharmacokinetic Quantifications Using LC-MS/MS.
Topics: Allopurinol; Calibration; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Hepatic Insufficiency; Humans; Kidney; Liver; Oxypurinol; Reference Standards; Renal Insufficiency; Renal Reabsorption; Reproducibility of Results; Tandem Mass Spectrometry; Thioglycolates; Triazoles; Uricosuric Agents; Verapamil | 2019 |
Impact of Lesinurad and allopurinol on experimental Hyperuricemia in mice: biochemical, molecular and Immunohistochemical study.
Topics: Allopurinol; Animals; Blood Urea Nitrogen; Catalase; Drug Synergism; Glutathione Peroxidase; Gout Suppressants; Hyperuricemia; Interleukin-1beta; Kidney; Liver; Male; Mice; Thioglycolates; Triazoles; Tumor Necrosis Factor-alpha; Uric Acid; Xanthine Oxidase | 2020 |
Application of different spectrofluorimetric methods for determination of lesinurad and allopurinol in pharmaceutical preparation and human plasma.
Topics: Allopurinol; Calibration; Humans; Spectrometry, Fluorescence; Thioglycolates; Triazoles | 2021 |
Trends in Utilization of Urate-Lowering Therapies Following the US Food and Drug Administration's Boxed Warning on Febuxostat.
Topics: Allopurinol; Cardiovascular Diseases; Cause of Death; Drug Labeling; Febuxostat; Gout; Gout Suppressants; Humans; Mortality; Polyethylene Glycols; Practice Patterns, Physicians'; Probenecid; Risk Factors; Thioglycolates; Triazoles; United States; United States Food and Drug Administration; Urate Oxidase | 2021 |
Spectrophotometric determination of lesinurad and allopurinol in recently approved FDA pharmaceutical preparation.
Topics: Allopurinol; Spectrophotometry; Thioglycolates; Triazoles | 2021 |
Different chemometric assisted approaches for spectrophotometric quantitative analysis of lesinurad and allopurinol.
Topics: Allopurinol; Least-Squares Analysis; Spectrophotometry; Thioglycolates; Triazoles | 2021 |
Synthesis, inhibition properties against xanthine oxidase and molecular docking studies of dimethyl N-benzyl-1H-1,2,3-triazole-4,5-dicarboxylate and (N-benzyl-1H-1,2,3-triazole-4,5-diyl)dimethanol derivatives.
Topics: Animals; Cattle; Dose-Response Relationship, Drug; Enzyme Inhibitors; Milk; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Triazoles; Xanthine Oxidase | 2021 |
Discovery of 4-(phenoxymethyl)-1H-1,2,3-triazole derivatives as novel xanthine oxidase inhibitors.
Topics: Animals; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Hyperuricemia; Ligands; Models, Molecular; Molecular Structure; Oxonic Acid; Rats; Structure-Activity Relationship; Triazoles; Uric Acid; Xanthine Oxidase | 2022 |
Design, synthesis, and biological evaluation of isatin-indole-3-carboxaldehyde hybrids as a new class of xanthine oxidase inhibitors.
Topics: Enzyme Inhibitors; Indoles; Isatin; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Triazoles; Xanthine Oxidase | 2022 |
Different spectrophotometric methods for simultaneous determination of lesinurad and allopurinol in the new FDA approved pharmaceutical preparation; additional greenness evaluation.
Topics: Allopurinol; Gout; Gout Suppressants; Humans; Triazoles | 2023 |
Discovery of novel 1,2,4-triazole derivatives as xanthine oxidoreductase inhibitors with hypouricemic effects.
Topics: Animals; Enzyme Inhibitors; Febuxostat; Gout; Hyperuricemia; Mice; Triazoles; Xanthine Dehydrogenase; Xanthine Oxidase | 2022 |