epiyangambin profile

epiyangambin: a furofuran lignan; also a PAF receptor antagonist; from the leaves of Rollinia pickeli; RN given for epiyangambin, the (1S-(1alpha,3aalpha,4beta,6aalpha))-isomer; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Rollinia	genus	A plant genus of the family ANNONACEAE. Members contain aporphines, acetogenins and rollinone.[MeSH]	Annonaceae	The custard-apple plant family of the order Magnoliales, subclass Magnoliidae, class Magnoliopsida. Some members provide large pulpy fruits and commercial timber. Leaves and wood are often fragrant. Leaves are simple, with smooth margins, and alternately arranged in two rows along the stems.[MeSH]

ID Source	ID
PubMed CID	10049223
CHEMBL ID	510536
MeSH ID	M0220557

Synonym
24192-64-1
MEGXP0_001363
NCGC00180070-01
ACON1_001856
epiyangambin
BRD-K29039292-001-01-5
CHEMBL510536
lirioresinol a, dimethyl-
nsc 172767
lirioresinol a, o,o-dimethyl-
1h,3h-furo(3,4-c)furan, tetrahydro-1,4-bis(3,4,5-trimethoxyphenyl)-, (1s-(1alpha,3aalpha,4beta,6aalpha))-
lirioresinol a dimethyl ether
o,o-dimethyllirioresinol a
(3r,3ar,6s,6ar)-3,6-bis(3,4,5-trimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan
1h,3h-furo[3,4-c]furan, tetrahydro-1,4-bis(3,4,5-trimethoxyphenyl)-, (1r,3ar,4s,6ar)-
DTXSID401035064
AKOS040761692
CS-0081825
HY-121377

Excerpt	Relevance	Reference
" Dose-response curves to noradrenaline-induced vasoconstriction were performed before and after continuous infusions of two different PAF-receptor antagonists (WEB 2086 and yangambin) and of the phospholipase A2 inhibitor mepacrine."	( Involvement of platelet-activating factor in the modulation of vascular tone in the isolated perfused rabbit kidney. Aimbire, F; Cailleaux, S; Cordeiro, RS; Lopes-Martins, RA; Tibiriçá, E, 1999)	0.3

Assay ID	Title	Year	Journal	Article
AID361151	Ratio of IC50 for mouse JB6 cells to IC50 for inhibition of 12-O-tetradecanoylphorbol 13-acetate-induced transformation of mouse JB6 cells	2002	Journal of natural products, Jul, Volume: 65, Issue:7	Constituents of the twigs of Hernandia ovigera that inhibit the transformation of JB6 murine epidermal cells.
AID361149	Inhibition of 12-O-tetradecanoylphorbol 13-acetate-induced transformation of mouse JB6 cells after 14 days by soft agar assay	2002	Journal of natural products, Jul, Volume: 65, Issue:7	Constituents of the twigs of Hernandia ovigera that inhibit the transformation of JB6 murine epidermal cells.
AID361150	Cytotoxicity against mouse JB6 cells after 3 days by trypan blue staining	2002	Journal of natural products, Jul, Volume: 65, Issue:7	Constituents of the twigs of Hernandia ovigera that inhibit the transformation of JB6 murine epidermal cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	6 (37.50)	18.2507
2000's	6 (37.50)	29.6817
2010's	3 (18.75)	24.3611
2020's	1 (6.25)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (5.56%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	17 (94.44%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
quinacrine Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.. quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.	2	1	acridines; aromatic ether; organochlorine compound; tertiary amino compound	antimalarial; EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor
potassium chloride Potassium Chloride: A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.. potassium chloride : A metal chloride salt with a K(+) counterion.	2.1	1	inorganic chloride; inorganic potassium salt; potassium salt	fertilizer
phenylephrine Phenylephrine: An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.. phenylephrine : A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.	2.1	1	phenols; phenylethanolamines; secondary amino compound	alpha-adrenergic agonist; cardiotonic drug; mydriatic agent; nasal decongestant; protective agent; sympathomimetic agent; vasoconstrictor agent
thiazoles [no description available]	2.39	2	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
acridine orange Acridine Orange: A cationic cytochemical stain specific for cell nuclei, especially DNA. It is used as a supravital stain and in fluorescence cytochemistry. It may cause mutations in microorganisms.. acridine orange : Fluorescent dye useful for cell cycle determination. It is cell-permeable, and interacts with DNA and RNA by intercalation or electrostatic attractions respectively.. acridine orange free base : A member of the class of aminoacridines that is acridine carrying two dimethylamino substituents at positions 3 and 6. The hydrochloride salt is the fluorescent dye 'acridine orange', used for cell cycle determination.	2.06	1	aminoacridines; aromatic amine; tertiary amino compound	fluorochrome; histological dye
web 2086 WEB 2086: structure given in first source; PAF antagonist	2.91	4	organonitrogen heterocyclic compound; organosulfur heterocyclic compound
triazoles Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.	2.91	4	1,2,3-triazole
1-hexadecyl-2-acetyl-glycero-3-phosphocholine Platelet Activating Factor: A phospholipid derivative formed by PLATELETS; BASOPHILS; NEUTROPHILS; MONOCYTES; and MACROPHAGES. It is a potent platelet aggregating agent and inducer of systemic anaphylactic symptoms, including HYPOTENSION; THROMBOCYTOPENIA; NEUTROPENIA; and BRONCHOCONSTRICTION.. 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine : A 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine betaine which has hexadecyl as the alkyl group. PAF is a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation, inflammation, and anaphylaxis.	4.34	6	2-acetyl-1-alkyl-sn-glycero-3-phosphocholine	antihypertensive agent; beta-adrenergic antagonist; bronchoconstrictor agent; hematologic agent; vasodilator agent
foropafant Foropafant: structure given in first source; PAF antagonist	2.39	2
lignin Lignin: The most abundant natural aromatic organic polymer found in all vascular plants. Lignin together with cellulose and hemicellulose are the major cell wall components of the fibers of all wood and grass species. Lignin is composed of coniferyl, p-coumaryl, and sinapyl alcohols in varying ratios in different plant species. (From Merck Index, 11th ed). lignin : A polyphenylpropanoid derived from three monolignol monomers: trans-p-coumaryl alcohol, coniferol and trans-sinapyl alcohol. There is extensive cross-linking and no defined primary structure.	1.98	1
kobusin kobusin: from flower buds of Magnolia fargesii; structure in first source. demethoxyaschantin : A member of the class of furofurans that is tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-1,3-benzodioxole carrying an additional 3,4-dimethoxyphenyl substituent at position 4.	2.13	1	benzodioxoles; dimethoxybenzene; furofuran; lignan	plant metabolite
n-methylcorydaldine N-methylcorydaldine: isolated from Annona squamosa twigs; structure in first source	2.01	1	quinolone	metabolite
yatein yatein: isolated from Anthriscus sylvestris; structure in first source. dihydroanhydropodorhizol : A member of the class of butan-4-olides carrying 3,4,5-trimethoxybenzyl and (1,3-benzodioxol-5-yl)methyl substituents at positions 3 and 4 respectively.	2.01	1	benzodioxoles; butan-4-olide; lignan; methoxybenzenes	plant metabolite
lignans Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)	5.19	15
yangambin [no description available]	2.01	1	lignan
dinoprost Dinoprost: A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions.. prostaglandin F2alpha : A prostaglandins Falpha that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9, 11 and 15. It is a naturally occurring prostaglandin used to induce labor.	2	1	monocarboxylic acid; prostaglandins Falpha	human metabolite; mouse metabolite
cardiovascular agents Cardiovascular Agents: Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.	3.1	1

Condition	Relationship Strength	Studies
Leishmaniasis, American [description not available]	2.41	1
Leishmaniasis, Cutaneous An endemic disease that is characterized by the development of single or multiple localized lesions on exposed areas of skin that typically ulcerate. The disease has been divided into Old and New World forms. Old World leishmaniasis is separated into three distinct types according to epidemiology and clinical manifestations and is caused by species of the L. tropica and L. aethiopica complexes as well as by species of the L. major genus. New World leishmaniasis, also called American leishmaniasis, occurs in South and Central America and is caused by species of the L. mexicana or L. braziliensis complexes.	2.41	1
Blood Pressure, Low [description not available]	2.1	1
Tachyarrhythmia [description not available]	2.1	1
Hypotension Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.	2.1	1
Tachycardia Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.	2.1	1
B16 Melanoma [description not available]	2.13	1
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	2.03	1
Thrombopenia [description not available]	2.68	3
Thrombocytopenia A subnormal level of BLOOD PLATELETS.	2.68	3
Leukocytosis A transient increase in the number of leukocytes in a body fluid.	1.99	1
Pleurisy INFLAMMATION of PLEURA, the lining of the LUNG. When PARIETAL PLEURA is involved, there is pleuritic CHEST PAIN.	1.99	1
Leukocytopenia [description not available]	1.99	1
Leukopenia A decrease in the number of LEUKOCYTES in a blood sample below the normal range (LEUKOCYTE COUNT less than 4000).	1.99	1
Shock, Cardiogenic Shock resulting from diminution of cardiac output in heart disease.	2	1
Endotoxin Shock [description not available]	3.33	2
Shock, Septic Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.	3.33	2
Anaphylactic Reaction [description not available]	2.92	1
Anaphylaxis An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.	2.92	1

epiyangambin

Description

Cross-References

Synonyms (19)

Research Excerpts

Dosage Studied

Bioassays (3)

Research

Studies (16)

Study Types