| Assay ID | Title | Year | Journal | Article |
|---|
| AID1633831 | Cytotoxicity against human MCF7 cells assessed as reduction in growth after 3 days by MTT assay | 2019 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 29, Issue:15
| Revisiting microtubule targeting agents: α-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics. |
| AID1623547 | Cytotoxicity against human HCT15 cells after 48 hrs by sulforhodamine B assay | 2019 | Journal of natural products, 03-22, Volume: 82, Issue:3
| Structure Elucidation, Conformation, and Configuration of Cytotoxic 6-Heptyl-5,6-dihydro-2 H-pyran-2-ones from Hyptis Species and Their Molecular Docking to α-Tubulin. |
| AID1393348 | Binding affinity to alpha tubulin in human A2780 cells assessed as disruption of tubulin polymerization by measuring reduction in cell proliferation after 48 hrs by CellTiter non-radioactive assay | 2018 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 28, Issue:16
| Synthesis and evaluation of C2 functionalized analogs of the α-tubulin-binding natural product pironetin. |
| AID598271 | Induction of abberant mitosis in human A549 cells assessed as metaphase mitotic cells with DNA forming a ring surrounding mono-aster of microtubule at 50 nM after 4 hrs relative to control | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5
| Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubules. |
| AID1572456 | Protein binding in mouse plasma | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Identification of the Metabolic Profile of the α-Tubulin-Binding Natural Product (-)-Pironetin. |
| AID1633825 | Toxicity in CDF1-SLC mouse injected with mouse P388 cells assessed as change in body weight at 0.78 mg/kg, ip treated for 5 days and measured on day 1 and 10 (Rvb = 5.3g) | 2019 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 29, Issue:15
| Revisiting microtubule targeting agents: α-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics. |
| AID598274 | Inhibition of tubulin assembly assessed as concentration of tubulin required to produce assembly at 25 uM after 30 mins | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5
| Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubules. |
| AID1165179 | Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth after 72 hrs by MTT assay | 2014 | European journal of medicinal chemistry, Nov-24, Volume: 87 | Design and synthesis of pironetin analogue/combretastatin A-4 hybrids containing a 1,2,3-triazole ring and evaluation of their cytotoxic activity. |
| AID598264 | Cytotoxicity against compound-resistant human A2780AD cells after 24 hrs by MTT assay | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5
| Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubules. |
| AID1572458 | Inhibition of CYP2C9 (unknown origin) using tolbutamide as substrate | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Identification of the Metabolic Profile of the α-Tubulin-Binding Natural Product (-)-Pironetin. |
| AID1633821 | Cytotoxicity against C57BL/6 mouse EL4 cells assessed as reduction in growth after 3 days | 2019 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 29, Issue:15
| Revisiting microtubule targeting agents: α-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics. |
| AID1633834 | Cytotoxicity against human T98G cells assessed as reduction in growth after 4 days by MTS assay | 2019 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 29, Issue:15
| Revisiting microtubule targeting agents: α-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics. |
| AID1572460 | Inhibition of CYP3A4 (unknown origin) using midazolam as substrate | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Identification of the Metabolic Profile of the α-Tubulin-Binding Natural Product (-)-Pironetin. |
| AID1633823 | Cytotoxicity against human H69/Txl cells assessed as reduction in growth after 7 days by MTT assay | 2019 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 29, Issue:15
| Revisiting microtubule targeting agents: α-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics. |
| AID1633843 | Antitumor activity in CDF1-SLC mouse injected with mouse P388 cells assessed as mean survival time at 6.25 mg/kg, ip treated for 5 days (Rvb = 11.2 +/- 0.84 days) | 2019 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 29, Issue:15
| Revisiting microtubule targeting agents: α-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics. |
| AID1572455 | Protein binding in human plasma | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Identification of the Metabolic Profile of the α-Tubulin-Binding Natural Product (-)-Pironetin. |
| AID1633824 | Cytotoxicity against human H69/VDS cells assessed as reduction in growth after 7 days by MTT assay | 2019 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 29, Issue:15
| Revisiting microtubule targeting agents: α-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics. |
| AID598263 | Cytotoxicity against compound-sensitive human A2780 cells after 24 hrs by MTT assay | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5
| Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubules. |
| AID1633833 | Cytotoxicity against mouse P388 cells assessed as reduction in growth after 24 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 29, Issue:15
| Revisiting microtubule targeting agents: α-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics. |
| AID1165182 | Selectivity index, ratio of IC50 for HEK293 cells to IC50 for human HT-29 cells | 2014 | European journal of medicinal chemistry, Nov-24, Volume: 87 | Design and synthesis of pironetin analogue/combretastatin A-4 hybrids containing a 1,2,3-triazole ring and evaluation of their cytotoxic activity. |
| AID1633842 | Antitumor activity in CDF1-SLC mouse injected with mouse P388 cells assessed as mean survival time at 3.13 mg/kg, ip treated for 5 days (Rvb = 11.2 +/- 0.84 days) | 2019 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 29, Issue:15
| Revisiting microtubule targeting agents: α-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics. |
| AID1238300 | Inhibition of VEGF mRNA expression in human HT-29 cells assessed as VEGF mRNA level at 5 ug/ml incubated for 48 hrs by RT-PCR method relative to control | 2015 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16
| Inhibitory effect of pironetin analogue/colchicine hybrids on the expression of the VEGF, hTERT and c-Myc genes. |
| AID1633841 | Antitumor activity in CDF1-SLC mouse injected with mouse P388 cells assessed as mean survival time at 1.56 mg/kg, ip treated for 5 days (Rvb = 11.2 +/- 0.84 days) | 2019 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 29, Issue:15
| Revisiting microtubule targeting agents: α-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics. |
| AID1572449 | Stability in human serum assessed as compound remaining at 1.10 mg after 24 hrs by HPLC analysis | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Identification of the Metabolic Profile of the α-Tubulin-Binding Natural Product (-)-Pironetin. |
| AID1238302 | Inhibition of Myc mRNA expression in human HT-29 cells assessed as Myc mRNA level at 5 ug/ml incubated for 48 hrs by RT-PCR method relative to control | 2015 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16
| Inhibitory effect of pironetin analogue/colchicine hybrids on the expression of the VEGF, hTERT and c-Myc genes. |
| AID1393347 | Binding affinity to alpha tubulin in human A2780 cells assessed as disruption of tubulin polymerization by measuring cell proliferation at higher concentration after 48 hrs by CellTiter non-radioactive assay relative to control | 2018 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 28, Issue:16
| Synthesis and evaluation of C2 functionalized analogs of the α-tubulin-binding natural product pironetin. |
| AID1165180 | Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth after 72 hrs by MTT assay | 2014 | European journal of medicinal chemistry, Nov-24, Volume: 87 | Design and synthesis of pironetin analogue/combretastatin A-4 hybrids containing a 1,2,3-triazole ring and evaluation of their cytotoxic activity. |
| AID1165183 | Selectivity index, ratio of IC50 for HEK293 cells to IC50 for human MCF7 cells | 2014 | European journal of medicinal chemistry, Nov-24, Volume: 87 | Design and synthesis of pironetin analogue/combretastatin A-4 hybrids containing a 1,2,3-triazole ring and evaluation of their cytotoxic activity. |
| AID1238301 | Inhibition of hTERT mRNA expression in human HT-29 cells assessed as hTERT mRNA level at 5 ug/ml incubated for 48 hrs by RT-PCR method relative to control | 2015 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16
| Inhibitory effect of pironetin analogue/colchicine hybrids on the expression of the VEGF, hTERT and c-Myc genes. |
| AID1189598 | Inhibition of purified tubulin (unknown origin) assessed as critical concentration of tubulin required to produce assembly at 25 uM after 30 mins by spectrophotometry (Rvb = 3.3 +/- 0.1 uM) | 2014 | Journal of medicinal chemistry, Dec-26, Volume: 57, Issue:24
| Design and synthesis of pironetin analogue/colchicine hybrids and study of their cytotoxic activity and mechanisms of interaction with tubulin. |
| AID1633827 | Cytotoxicity against human HL60 cells assessed as reduction in growth after 24 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 29, Issue:15
| Revisiting microtubule targeting agents: α-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics. |
| AID1633835 | Cytotoxicity against hamster VCRd5L cells assessed as reduction in growth after 4 days by HCS assay | 2019 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 29, Issue:15
| Revisiting microtubule targeting agents: α-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics. |
| AID1572454 | Half life in rat liver microsomes in presence of NADPH regeneration system by LC-MS/MS analysis | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Identification of the Metabolic Profile of the α-Tubulin-Binding Natural Product (-)-Pironetin. |
| AID1633819 | Cytotoxicity against human A549 cells assessed as reduction in growth after 4 days by HCS assay | 2019 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 29, Issue:15
| Revisiting microtubule targeting agents: α-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics. |
| AID1189590 | Selectivity ratio of IC50 for human HEK293 cells to IC50 for human MCF7 cells | 2014 | Journal of medicinal chemistry, Dec-26, Volume: 57, Issue:24
| Design and synthesis of pironetin analogue/colchicine hybrids and study of their cytotoxic activity and mechanisms of interaction with tubulin. |
| AID598270 | Induction of abberant mitosis in human A549 cells assessed as metaphase mitotic cells with type III mitotic spindles at 50 nM after 4 hrs relative to control | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5
| Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubules. |
| AID1633829 | Cytotoxicity against human K562 cells assessed as reduction in growth after 4 days by MTT assay | 2019 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 29, Issue:15
| Revisiting microtubule targeting agents: α-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics. |
| AID598262 | Cell cycle arrest in human A549 cells assessed accumulation at G2/M phase at 50 nM after 20 hrs by propidium iodide staining-based flow cytometry | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5
| Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubules. |
| AID1572450 | Stability in mouse serum assessed as compound remaining at 1.30 ml after 24 hrs by HPLC analysis | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Identification of the Metabolic Profile of the α-Tubulin-Binding Natural Product (-)-Pironetin. |
| AID1633838 | Toxicity in CDF1-SLC mouse injected with mouse P388 cells assessed as change in body weight at 3.13 mg/kg, ip treated for 5 days and measured on day 1 and 10 (Rvb = 5.3g) | 2019 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 29, Issue:15
| Revisiting microtubule targeting agents: α-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics. |
| AID1633828 | Cytotoxicity against rat KNRK cells assessed as reduction in growth | 2019 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 29, Issue:15
| Revisiting microtubule targeting agents: α-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics. |
| AID1189587 | Cytotoxicity against human MCF7 cells after 3 days by MTT assay | 2014 | Journal of medicinal chemistry, Dec-26, Volume: 57, Issue:24
| Design and synthesis of pironetin analogue/colchicine hybrids and study of their cytotoxic activity and mechanisms of interaction with tubulin. |
| AID1189601 | Resistance factor, ratio of IC50 for human A2780AD cells to IC50 for human A2780 cells | 2014 | Journal of medicinal chemistry, Dec-26, Volume: 57, Issue:24
| Design and synthesis of pironetin analogue/colchicine hybrids and study of their cytotoxic activity and mechanisms of interaction with tubulin. |
| AID1572461 | Inhibition of CYP3A4 (unknown origin) using testosterone as substrate | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Identification of the Metabolic Profile of the α-Tubulin-Binding Natural Product (-)-Pironetin. |
| AID1165181 | Cytotoxicity against HEK293 cells assessed as inhibition of cell growth after 72 hrs by MTT assay | 2014 | European journal of medicinal chemistry, Nov-24, Volume: 87 | Design and synthesis of pironetin analogue/combretastatin A-4 hybrids containing a 1,2,3-triazole ring and evaluation of their cytotoxic activity. |
| AID1572453 | Half life in mouse liver microsomes in presence of NADPH regeneration system by LC-MS/MS analysis | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Identification of the Metabolic Profile of the α-Tubulin-Binding Natural Product (-)-Pironetin. |
| AID1633832 | Cytotoxicity against human MDA-MB-231 cells assessed as reduction in growth after 4 days by HCS assay | 2019 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 29, Issue:15
| Revisiting microtubule targeting agents: α-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics. |
| AID1189600 | Cytotoxicity against human A2780AD cells after 24 hrs by MTT assay | 2014 | Journal of medicinal chemistry, Dec-26, Volume: 57, Issue:24
| Design and synthesis of pironetin analogue/colchicine hybrids and study of their cytotoxic activity and mechanisms of interaction with tubulin. |
| AID598265 | Resistance index, ratio of IC50 for human compound-sensitive A2780 cells to IC50 for human compound-resistant A2780AD cells | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5
| Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubules. |
| AID1572462 | Drug metabolism in human liver microsomes assessed as formation of epoxypironetin after 30 mins by LC-MS/MS analysis | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Identification of the Metabolic Profile of the α-Tubulin-Binding Natural Product (-)-Pironetin. |
| AID598277 | Binding affinity to tubulin after 15 min | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5
| Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubules. |
| AID1633822 | Cytotoxicity against human H69 cells assessed as reduction in growth after 7 days by MTT assay | 2019 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 29, Issue:15
| Revisiting microtubule targeting agents: α-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics. |
| AID1572467 | Inhibition of tubulin alpha in human A2780CP cells assessed as cell growth inhibition after 48 hrs by MTT assay | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Identification of the Metabolic Profile of the α-Tubulin-Binding Natural Product (-)-Pironetin. |
| AID1623546 | Cytotoxicity against human HeLa cells after 48 hrs by sulforhodamine B assay | 2019 | Journal of natural products, 03-22, Volume: 82, Issue:3
| Structure Elucidation, Conformation, and Configuration of Cytotoxic 6-Heptyl-5,6-dihydro-2 H-pyran-2-ones from Hyptis Species and Their Molecular Docking to α-Tubulin. |
| AID1633839 | Toxicity in CDF1-SLC mouse injected with mouse P388 cells assessed as change in body weight at 6.25 mg/kg, ip treated for 5 days and measured on day 1 and 10 (Rvb = 5.3g) | 2019 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 29, Issue:15
| Revisiting microtubule targeting agents: α-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics. |
| AID1189586 | Cytotoxicity against human HT-29 cells after 3 days by MTT assay | 2014 | Journal of medicinal chemistry, Dec-26, Volume: 57, Issue:24
| Design and synthesis of pironetin analogue/colchicine hybrids and study of their cytotoxic activity and mechanisms of interaction with tubulin. |
| AID1572451 | Stability in rat serum assessed as compound remaining after 24 hrs | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Identification of the Metabolic Profile of the α-Tubulin-Binding Natural Product (-)-Pironetin. |
| AID1572465 | Inhibition of tubulin alpha in human A2780 cells assessed as reduction in cell growth | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Identification of the Metabolic Profile of the α-Tubulin-Binding Natural Product (-)-Pironetin. |
| AID1572463 | Drug metabolism in human liver microsomes assessed as formation of demethylpironetin after 30 mins by LC-MS/MS analysis | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Identification of the Metabolic Profile of the α-Tubulin-Binding Natural Product (-)-Pironetin. |
| AID1633826 | Cytotoxicity against human HeLa cells assessed as reduction in growth | 2019 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 29, Issue:15
| Revisiting microtubule targeting agents: α-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics. |
| AID598268 | Induction of apoptosis in human A549 cells after 20 hrs | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5
| Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubules. |
| AID1572466 | Inhibition of tubulin alpha in human A2780 cells assessed as cell growth inhibition after 48 hrs by MTT assay | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Identification of the Metabolic Profile of the α-Tubulin-Binding Natural Product (-)-Pironetin. |
| AID1393349 | Binding affinity to alpha tubulin in human OVCAR5 cells assessed as disruption of tubulin polymerization by measuring reduction in cell proliferation after 48 hrs by CellTiter non-radioactive assay | 2018 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 28, Issue:16
| Synthesis and evaluation of C2 functionalized analogs of the α-tubulin-binding natural product pironetin. |
| AID1633836 | Immunosuppressive activity in C3/HeN mouse injected with C57BL/6 mouse EL4 cells assessed as cytotoxic T cells generation by measuring specific lysis level at 5 mg/kg, ip treated for 2 to 15 days and measured on day 16 by gamma scintillation counter metho | 2019 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 29, Issue:15
| Revisiting microtubule targeting agents: α-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics. |
| AID1572452 | Half life in human liver microsomes in presence of NADPH regeneration system by LC-MS/MS analysis | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Identification of the Metabolic Profile of the α-Tubulin-Binding Natural Product (-)-Pironetin. |
| AID1189599 | Cytotoxicity against human A2780 cells after 24 hrs by MTT assay | 2014 | Journal of medicinal chemistry, Dec-26, Volume: 57, Issue:24
| Design and synthesis of pironetin analogue/colchicine hybrids and study of their cytotoxic activity and mechanisms of interaction with tubulin. |
| AID1189589 | Selectivity ratio of IC50 for human HEK293 cells to IC50 for human HT29 cells | 2014 | Journal of medicinal chemistry, Dec-26, Volume: 57, Issue:24
| Design and synthesis of pironetin analogue/colchicine hybrids and study of their cytotoxic activity and mechanisms of interaction with tubulin. |
| AID1572457 | Protein binding in rat plasma | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Identification of the Metabolic Profile of the α-Tubulin-Binding Natural Product (-)-Pironetin. |
| AID1572459 | Inhibition of CYP2D6 (unknown origin) using dextromethorphan as substrate | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Identification of the Metabolic Profile of the α-Tubulin-Binding Natural Product (-)-Pironetin. |
| AID1633840 | Antitumor activity in CDF1-SLC mouse injected with mouse P388 cells assessed as mean survival time at 0.78 mg/kg, ip treated for 5 days (Rvb = 11.2 +/- 0.84 days) | 2019 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 29, Issue:15
| Revisiting microtubule targeting agents: α-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics. |
| AID1238299 | Inhibition of VEGF production in human HT-29 cells assessed as VEGF level at 5 ug/ml incubated for 72 hrs by ELISA method relative to control | 2015 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16
| Inhibitory effect of pironetin analogue/colchicine hybrids on the expression of the VEGF, hTERT and c-Myc genes. |
| AID1189588 | Cytotoxicity against human HEK293 cells after 3 days by MTT assay | 2014 | Journal of medicinal chemistry, Dec-26, Volume: 57, Issue:24
| Design and synthesis of pironetin analogue/colchicine hybrids and study of their cytotoxic activity and mechanisms of interaction with tubulin. |
| AID1633837 | Toxicity in CDF1-SLC mouse injected with mouse P388 cells assessed as change in body weight at 1.56 mg/kg, ip treated for 5 days and measured on day 1 and 10 (Rvb = 5.3g) | 2019 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 29, Issue:15
| Revisiting microtubule targeting agents: α-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics. |
| AID598269 | Induction of microtubule cytoskeleton depolymerization in human A549 cells at 50 nM after 4 hrs by immunofluorescence assay | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5
| Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubules. |
| AID1623545 | Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay | 2019 | Journal of natural products, 03-22, Volume: 82, Issue:3
| Structure Elucidation, Conformation, and Configuration of Cytotoxic 6-Heptyl-5,6-dihydro-2 H-pyran-2-ones from Hyptis Species and Their Molecular Docking to α-Tubulin. |
| AID1633830 | Cytotoxicity against human K562/ADR cells assessed as reduction in growth after 4 days by MTT assay | 2019 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 29, Issue:15
| Revisiting microtubule targeting agents: α-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics. |
| AID1633820 | Cytotoxicity against hamster DC-3F cells assessed as reduction in growth after 4 days by HCS assay | 2019 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 29, Issue:15
| Revisiting microtubule targeting agents: α-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |