Myelolipoma

A rare benign tumor of the adrenal gland, several centimeters in diameter, composed in varying proportions of adipose tissue, lymphocytes, and primitive myeloid cells, probably a developmental abnormality. (Dorland, 27th ed)

Synonym
Myelolipoma

Excerpt	Reference
"Adrenal myelolipomas are rare nonfunctioning neoplasias consisting of a variable mixture of mature fat and bone marrow tissue."	( Boraschi, P; Braccini, G; Campatelli, A; Cartei, F; Di Vito, A; Gigoni, R; Perri, G, 1996)
"Myelolipoma is a rare, hormonally inactive, benign tumor consisting of fat and hematopoietic cells."	( Adams, S; Liermann, D; Mruck, S, 2009)
"Adrenal myelolipomas are uncommon benign tumors, composed of mature adipose tissue and haematopoietic elements in varying proportions."	( Alfaro, JJ; Atienzar, M; Botella, F; Lamas, C; López, LM; Lozano, E; Ruiz-Mondéjar, R, 2009)
"Myelolipomas are adrenal tumors composed of both adipose and hematopoietic tissues which are rarely associated with primary aldosteronism (PA)."	( Arai, H; Fujii, T; Fukuda, Y; Honda, K; Inuzuka, M; Kanamoto, N; Kojima, K; Kondo, E; Mikami, Y; Miura, M; Nakao, K; Sasano, H; Sone, M; Sonoyama, T; Tamura, N; Taura, D; Ueda, Y; Yamada, G; Yamashita, Y; Yasoda, A, 2012)
"Adrenal myelolipoma is a benign hormone-inactive tumor composed of hematopoietic tissue and mature adipose tissue."	( Inamura, K; Kohno, A; Koizumi, M; Numao, N; Yamamoto, T, 2019)

Excerpt	Reference
"Myelolipomas have occasionally been found in patients with Cushing's syndrome, pheochromocytoma and hyperthyroidism."	( Bober, J; Lazurova, I; Pajtasova, D; Sokol, L; Trejbal, D; Zachar, M, 1998)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	10 (27.03)	12.5806
2000's	7 (18.92)	18.1394
2010's	15 (40.54)	28.8240
2020's	5 (13.51)	9.53

Drug	Relationship Strength	Studies	Trials
normetanephrine	low	1	0
amlodipine	low	1	0
pentetic acid	low	1	0
thalidomide	medium	1	1
aldosterone	low	11	0
prednisone	low	1	0
dehydroepiandrosterone	low	2	0
17-alpha-hydroxyprogesterone	low	2	0
hematoxylin	low	1	0
eosine yellowish-(ys)	low	1	0
dehydroepiandrosterone sulfate	low	2	0
sulfur hexafluoride	low	1	0
metanephrine	low	2	0
gadolinium	low	1	0
fludrocortisone	low	1	0
3-iodobenzylguanidine	low	1	0
triazoles	low	1	0
fluorodeoxyglucose f18	low	4	0
adosterol	low	1	0
deferasirox	low	1	0
cortisone	low	1	0
indium	low	1	0
gadolinium dtpa	low	1	0
19-iodocholesterol	low	1	0
6-iodomethylcholesterol	low	1	0
technetium tc 99m sulfur colloid	low	2	0
capromab pendetide	low	1	0

Protein Targets (254)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
acetylcholinesterase	1	0	0	1
pregnane X receptor	3	0	0	3
SMAD family member 2	3	0	0	3
SMAD family member 3	3	0	0	3
TDP1 protein	10	0	0	10
GLI family zinc finger 3	7	0	0	7
Microtubule-associated protein tau	2	0	0	2
AR protein	9	0	0	9
progesterone receptor	6	0	0	6
glucocorticoid receptor [Homo sapiens]	7	0	0	7
retinoic acid nuclear receptor alpha variant 1	5	0	0	5
retinoid X nuclear receptor alpha	5	0	0	5
estrogen-related nuclear receptor alpha	5	0	0	5
farnesoid X nuclear receptor	4	0	0	4
pregnane X nuclear receptor	4	0	0	4
estrogen nuclear receptor alpha	8	0	0	8
G	3	0	0	3
vitamin D (1,25- dihydroxyvitamin D3) receptor	4	0	0	4
arylsulfatase A	4	0	0	4
euchromatic histone-lysine N-methyltransferase 2	7	0	0	7
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	5	0	0	5
activating transcription factor 6	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
chromobox protein homolog 1	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 1	6	0	0	6
geminin	8	0	0	8
survival motor neuron protein isoform d	3	0	0	3
histone acetyltransferase KAT2A isoform 1	4	0	0	4
lamin isoform A-delta10	2	0	0	2
Voltage-dependent calcium channel gamma-2 subunit	2	0	0	2
Interferon beta	4	0	0	4
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
Glucocorticoid receptor	0	6	1	7
Sex hormone-binding globulin	0	0	4	4
Glycine receptor subunit alpha-1	0	6	0	6
Corticosteroid-binding globulin	0	4	0	4
Adenosine receptor A3	0	2	0	2
Replicase polyprotein 1ab	0	1	0	1
Androgen receptor	0	3	0	3
Alpha-1B adrenergic receptor	0	2	0	2
Glutamate receptor 2	2	0	0	2
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Mitogen-activated protein kinase 3	0	1	0	1
Alpha-1A adrenergic receptor	0	2	0	2
Sodium-dependent dopamine transporter	0	4	0	4
TAR DNA-binding protein 43	3	0	0	3
Inositol hexakisphosphate kinase 1	3	0	0	3
cytochrome P450 2C9, partial	3	0	0	3
ATP-dependent phosphofructokinase	5	0	0	5
dopamine D1 receptor	2	0	0	2
thioredoxin reductase	4	0	0	4
GLS protein	4	0	0	4
Thrombopoietin	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
cytochrome P450 2D6 isoform 1	1	0	0	1
cytochrome P450 2C19 precursor	2	0	0	2
ras-related protein Rab-9A	1	0	0	1
lethal factor (plasmid)	1	0	0	1
POU domain, class 2, transcription factor 1	0	0	0	1
Spike glycoprotein	3	0	0	3
thyroid hormone receptor beta isoform a	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
Mineralocorticoid receptor	0	1	2	3
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	2
Guanine nucleotide-binding protein G	1	0	0	1
Chain A, Ferritin light chain	1	0	0	1
acid sphingomyelinase	1	0	0	1
Smad3	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	6	0	0	6
cytochrome P450 2D6	3	0	0	3
IDH1	1	0	0	1
NEDD8-activating enzyme E1 regulatory subunit isoform a	0	1	0	1
NEDD8-conjugating enzyme Ubc12	0	1	0	1
nuclear receptor ROR-gamma isoform 1	3	0	0	3
ATP-binding cassette sub-family C member 3	0	2	0	2
Multidrug resistance-associated protein 4	0	3	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Potassium channel subfamily K member 2	0	1	1	2
Bile salt export pump	0	4	0	4
ATP-dependent translocase ABCB1	0	1	0	1
Alpha-2A adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 6	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Potassium channel subfamily K member 2	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	2	0	2
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
endonuclease IV	2	0	0	2
RAR-related orphan receptor gamma	5	0	0	5
aldehyde dehydrogenase 1 family, member A1	4	0	0	4
regulator of G-protein signaling 4	2	0	0	2
peroxisome proliferator-activated receptor delta	4	0	0	4
peroxisome proliferator activated receptor gamma	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	2	0	0	2
peripheral myelin protein 22 isoform 1	2	0	0	2
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
heat shock protein beta-1	2	0	0	2
flap endonuclease 1	4	0	0	4
cytochrome P450 3A4 isoform 1	2	0	0	2
M-phase phosphoprotein 8	2	0	0	2
muscarinic acetylcholine receptor M1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit delta	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-2	2	0	0	2
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
GABA theta subunit	2	0	0	2
Multidrug and toxin extrusion protein 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	2	0	0	2
Luciferase	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
Fumarate hydratase	1	0	0	1
estrogen receptor 2 (ER beta)	4	0	0	4
nuclear receptor subfamily 1, group I, member 3	2	0	0	2
EWS/FLI fusion protein	2	0	0	2
polyprotein	1	0	0	1
thyroid stimulating hormone receptor	2	0	0	2
Histone H2A.x	1	0	0	1
thyroid hormone receptor beta isoform 2	4	0	0	4
Lysine-specific demethylase 6B	0	1	0	1
Lysine-specific demethylase 4A	0	1	1	2
Cellular tumor antigen p53	3	0	0	3
Lysine-specific demethylase 5A	0	1	0	1
Flavin reductase (NADPH)	0	0	1	1
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
aryl hydrocarbon receptor	2	0	0	2
Beta-glucuronidase	0	1	0	1
Beta-glucuronidase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Alpha-synuclein	1	0	0	1
G-protein coupled bile acid receptor 1	0	0	2	2
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Steryl-sulfatase	0	0	0	1
Multidrug resistance-associated protein 1	0	0	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Solute carrier organic anion transporter family member 1B3	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier organic anion transporter family member 1B1	0	0	0	1
GALC protein	2	0	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	2	0	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
Chain E, Fibrin beta chain	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
15-lipoxygenase, partial	2	0	0	2
WRN	1	0	0	1
Mcl-1	0	1	0	1
phosphopantetheinyl transferase	1	0	0	1
MPI protein	0	1	0	1
USP1 protein, partial	2	0	0	2
Cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0	0	0	1
PPM1D protein	1	0	0	1
alkaline phosphatase, intestinal	0	0	1	1
thioredoxin glutathione reductase	3	0	0	3
apical membrane antigen 1, AMA1	1	0	0	1
hypothetical protein, conserved	1	0	0	1
67.9K protein	1	0	0	1
glucocerebrosidase	1	0	0	1
luciferase	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
pyruvate kinase	1	0	0	1
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
CDK5	0	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
major prion protein preproprotein Prp precursor	0	1	0	1
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	0	1	1
cellular tumor antigen p53 isoform a	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
vitamin D3 receptor isoform VDRA	2	0	0	2
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
intestinal alkaline phosphatase precursor	0	0	1	1
DNA polymerase beta	1	0	0	1
mitogen-activated protein kinase 1	1	0	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
DNA polymerase kappa isoform 1	1	0	0	1
Vif	0	1	0	1
Tat	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	0	1	0	1
alkaline phosphatase, germ cell type preproprotein	0	0	1	1
endoribonuclease toxin MazF	0	0	1	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Rap guanine nucleotide exchange factor 3	1	0	0	1
Integrin beta-3	1	0	0	1
Integrin alpha-IIb	1	0	0	1
Pyruvate kinase PKM	0	1	0	1
Endothelin receptor type B	1	0	0	1
Endothelin-1 receptor	1	0	0	1
Histamine H2 receptor	2	0	0	2
Inositol monophosphatase 1	1	0	0	1
phosphoglycerate kinase	1	0	0	1
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
large T antigen	0	1	0	1
thyroid stimulating hormone receptor	1	0	0	1
nonstructural protein 1	1	0	0	1
Bloom syndrome protein isoform 1	3	0	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
peripheral myelin protein 22	1	0	0	1
ATPase family AAA domain-containing protein 5	1	0	0	1
Ataxin-2	1	0	0	1
Nuclear receptor ROR-gamma	1	0	0	1
Cereblon isoform 4	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
Chain A, Beta-lactamase	1	0	0	1
Chain A, Cruzipain	1	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Research

Studies (37)

Protein Targets (254)

Myelolipoma

Synonyms(1)

Research Excerpts

Overview

Context

Research

Studies (37)

Drugs Studied (36)

Protein Targets (254)