Page last updated: 2024-11-12

fluorapatite

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

fluorapatite: RN refers to fluorapatite [Ca5F(PO4)3]) [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

apatite : A phosphate mineral with the general formula Ca5(PO4)3X where X = OH, F or Cl. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

fluorapatite : A phosphate mineral with the formula Ca5(PO4)3F. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID10207414
MeSH IDM0084099

Synonyms (14)

Synonym
einecs 215-144-1
fluorapatite
phosphate rock
apatite
m4cm1h238j ,
1306-05-4
unii-m4cm1h238j
apatite [hpus]
VSIIXMUUUJUKCM-UHFFFAOYSA-D
phospate rock
DTXSID2051429
fluorapatite (synthetic)
pentacalcium;fluoride;triphosphate
Q26841220

Research Excerpts

Effects

ExcerptReferenceRelevance
"Fluorapatite mullite has been developed from the dental glass-ceramics used for more general hard tissue replacement."( Fluorapatite-mullite glass sputter coated Ti6Al4V for biomedical applications.
Bibby, JK; Bubb, NL; Mummery, PM; Wood, DJ, 2005
)
2.49

Treatment

ExcerptReferenceRelevance
"Treatment of fluorapatite (prepared by incorporating basic species F(-) in apatite in situ by coprecipitation) with an aqueous solution of RhCl(3) resulted in rhodium-exchanged fluorapatite catalyst (RhFAP), which successfully promoted cross coupling of Baylis-Hillman adducts with arylboronic acids to yield trisubstituted olefins. "( Rhodium fluorapatite catalyst for the synthesis of trisubstituted olefins via cross coupling of Baylis-Hillman adducts and arylboronic acids.
Kantam, ML; Kumar, KB; Sreedhar, B, 2008
)
1.15

Compound-Compound Interactions

ExcerptReferenceRelevance
" The aim of this in vitro study was to evaluate the effects of fluoride mouthrinses or gels in combination with de-/remineralizing saliva substitutes on dentinal subsurface lesions."( Mineral distribution of artificial dentinal caries lesions after treatment with fluoride agents in combination with saliva substitutes.
Meyer-Lueckel, H; Tschoppe, P, 2011
)
0.37
"Under the in vitro conditions chosen, use of fluoride agents in combination with a demineralizing saliva substitute resulted in reduced mineral loss."( Mineral distribution of artificial dentinal caries lesions after treatment with fluoride agents in combination with saliva substitutes.
Meyer-Lueckel, H; Tschoppe, P, 2011
)
0.37

Bioavailability

ExcerptReferenceRelevance
" Furthermore, the bioavailability of dentifrices, in terms of formation of total fluorine (TF), CaF2, and fluorapatite (FA) on human dental enamel, was evaluated."( [Dose-response effect of a dentifrice formulation with low fluoride concentration - an in vitro study].
Cury, JA; Negri, HM,
)
0.34
" Most of the studies on Pb stabilization were performed using various phosphorus-containing amendments that can reduce Pb mobility and bioavailability by the sorption and precipitation of new, stable pyromorphite-type minerals, presenting very low solubility and bioaccessibility."( Theoretical assessment of phosphate amendments for stabilization of (Pb+Zn) in polluted soil.
Perovic, V; Raicevic, S; Zouboulis, AI, 2009
)
0.35

Dosage Studied

ExcerptRelevanceReference
"5, with 275, 550 and 1,100 ppm F (NaF/silica) were developed in order to assess dose-response effects."( [Dose-response effect of a dentifrice formulation with low fluoride concentration - an in vitro study].
Cury, JA; Negri, HM,
)
0.13
" We created distinct levels of CaF(2) on enamel to evaluate a dose-response effect."( Fluoride release from CaF2 and enamel demineralization.
Cerezetti, RV; Cury, JA; Del Bel Cury, AA; Tabchoury, CP; Tenuta, LM, 2008
)
0.35
" Changes in mineral distribution effected by F were most pronounced in MeC lesions, with remineralization/mineral redeposition in the original lesion body at the expense of sound enamel beyond the original lesion in a dose-response manner."( Effect of fluoride, lesion baseline severity and mineral distribution on lesion progression.
Butler, A; Hara, AT; Lippert, F; Lynch, RJ, 2012
)
0.38
"The present mechanistic in vitro study aimed to investigate dose-response effects of zinc and fluoride on caries lesion remineralization and subsequent protection from demineralization."( Dose-response effects of zinc and fluoride on caries lesion remineralization.
Lippert, F, 2012
)
0.38
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (404)

TimeframeStudies, This Drug (%)All Drugs %
pre-199061 (15.10)18.7374
1990's66 (16.34)18.2507
2000's84 (20.79)29.6817
2010's164 (40.59)24.3611
2020's29 (7.18)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 58.87

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index58.87 (24.57)
Research Supply Index6.10 (2.92)
Research Growth Index4.76 (4.65)
Search Engine Demand Index99.43 (26.88)
Search Engine Supply Index2.01 (0.95)

This Compound (58.87)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials23 (5.44%)5.53%
Reviews9 (2.13%)6.00%
Case Studies12 (2.84%)4.05%
Observational0 (0.00%)0.25%
Other379 (89.60%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]