Compounds > vrx-480773
Page last updated: 2024-11-12

vrx-480773

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Description

VRX-480773: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11519951
CHEMBL ID373571
SCHEMBL ID248867
MeSH IDM0510100

Synonyms (12)

Synonym
acetamide, n-[4-(aminosulfonyl)-2-chlorophenyl]-2-[[5-bromo-4-(4-cyclopropyl-1-naphthalenyl)-4h-1,2,4-triazol-3-yl]thio]-
2-[[5-bromo-4-(4-cyclopropyl-1-naphthyl)-1,2,4-triazol-3-yl]sulfanyl]-n-(2-chloro-4-sulfamoyl-phenyl)acetamide
vrx-480773
CHEMBL373571 ,
2-[5-bromo-4-(4-cyclopropyl-naphthalen-1-yl)-4h-[1,2,4]triazol-3-ylsulfanyl]-n-(2-chloro-4-sulfamoylphenyl)acetamide
JMAGRGYNUBAGRG-UHFFFAOYSA-N
2-[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4h-[1,2,4]triazol-3-ylsulfanyl]-n-(2-chloro-4-sulfamoylphenyl)acetamide
2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4h-1,2,4-triazol-3-ylthio)-n-(2-chloro-4-sulfamoylphenyl)acetamide
SCHEMBL248867
bdbm50476133
2-[[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-1,2,4-triazol-3-yl]sulfanyl]-n-(2-chloro-4-sulfamoylphenyl)acetamide
PD161402
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Reverse transcriptase/RNaseH Human immunodeficiency virus 1IC50 (µMol)0.00400.00011.076810.0000AID279503; AID569731
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (176)

Assay IDTitleYearJournalArticle
AID279521Antiviral activity against wild type HIV1 NL4-3 in Hela-JC53 cells in the presence of 40% human serum after 48 hrs2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279497Antiviral activity against HIV1 isolate with RT K103N-K101Q-P225H mutation2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279467Antiviral activity against HIV1 isolate with RT 106A, 181C mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279435Antiviral activity against HIV1 isolate with RT 101Q, 103R mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279463Antiviral activity against HIV1 isolate with RT 108I, 181C, 190A mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279542Inhibition of hepatitis C virus replication2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279479Antiviral activity against HIV1 isolate with RT 179D, 181C mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279421Antiviral activity against HIV1 isolate with RT 101E, 190S mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279543Inhibition of HIV2(NIH-Z) isolate2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279493Antiviral activity against HIV1 isolate V106I-Y188L mutant2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279480Antiviral activity against HIV1 isolate with RT 100F mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID1520054Antiviral activity against HIV1 harbouring NNRTI K103N mutant infected in human HeLa-JC3 cells assessed as virus-induced cytopathic effect incubated for 48 hrs by chemiluminescent method2020European journal of medicinal chemistry, Jan-01, Volume: 185Fragment hopping-based discovery of novel sulfinylacetamide-diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors.
AID717260Antiviral activity against HIV1 RES056 harboring reverse transcriptase K103N/Y181C mutant infected in human MT4 cells assessed as inhibition of virus-induced cytopathicity by MTT assay2012Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23
Structure-based bioisosterism design, synthesis and biological evaluation of novel 1,2,4-triazin-6-ylthioacetamides as potent HIV-1 NNRTIs.
AID279507Antiviral activity against HIV1 isolate with RT D123G mutation in Hela-JC-53 cells2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID1520053Antiviral activity against HIV1 infected in human HeLa-JC3 cells assessed as virus-induced cytopathic effect incubated for 48 hrs by chemiluminescent method2020European journal of medicinal chemistry, Jan-01, Volume: 185Fragment hopping-based discovery of novel sulfinylacetamide-diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors.
AID279448Antiviral activity against HIV1 isolate with RT 101H, 190A mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279534Plasma concentration in dog at 10 mg/kg, iv after 12 hrs2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279544Inhibition of wild type clade B HIV1 NL4-32007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279393Antiviral activity against HIV1 isolate with RT 106I mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279455Antiviral activity against HIV1 isolate with RT 103N, 188H mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279462Antiviral activity against HIV1 isolate with RT 103N, 108I, 190A mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279482Antiviral activity against HIV1 isolate with RT K103N mutation2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279489Antiviral activity against HIV1 isolate with RT K103N-V108I-P225H mutation2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279422Antiviral activity against HIV1 isolate with RT 190E mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279469Antiviral activity against HIV1 isolate with RT 238N mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279446Antiviral activity against HIV1 isolate with RT 101Q, 181C mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279511Antiviral activity against HIV1 isolate with RT V106I, Y181C mutation in Hela-JC-53 cells2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279398Antiviral activity against HIV1 isolate with RT 103N, 108I mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279440Antiviral activity against HIV1 isolate with RT 101R, 103N mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID1235377Antiviral activity against HIV1 RES056 expressing reverse transcriptase K103N + Y181C mutant infected in human MT4 cells assessed as inhibition of virus-induced cytopathicity incubated for 4 days by MTT method2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Hybrid chemistry. Part 4: Discovery of etravirine-VRX-480773 hybrids as potent HIV-1 non-nucleoside reverse transcriptase inhibitors.
AID569731Inhibition of HIV1 reverse transcriptase2011Journal of medicinal chemistry, Feb-10, Volume: 54, Issue:3
Deconstruction of non-nucleoside reverse transcriptase inhibitors of human immunodeficiency virus type 1 for exploration of the optimization landscape of fragments.
AID279476Antiviral activity against HIV1 isolate with RT 101N, 103N mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279538AUC in dog at 20 mg/kg, po2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279394Antiviral activity against HIV1 isolate with RT 98G mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279450Antiviral activity against HIV1 isolate with RT 98G, 103N, 181C mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279490Antiviral activity against HIV1 isolate with RT Y188L mutation2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279540Bioavailability in dog at 20 mg/kg, po2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279453Antiviral activity against HIV1 isolate with RT 98G, 100I, 103N mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279471Antiviral activity against HIV1 isolate with RT 103N, 238N mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279526Antiviral activity against HIV1 NL4-3 with Y188L mutation in Hela-JC53 cells in the presence of 20% human serum after 48 hrs2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279517Antiviral activity against wild type HIV1 NL4-3 in Hela-JC53 cells in the presence of 5% human serum after 48 hrs2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279466Antiviral activity against HIV1 isolate with RT 103N, 190S mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279405Antiviral activity against HIV1 isolate with RT 101E, 190A mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279433Antiviral activity against HIV1 isolate with RT 179T mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279402Antiviral activity against HIV1 isolate with RT 103N, 190A mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279418Antiviral activity against HIV1 isolate with RT 98G, 181C mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279411Antiviral activity against HIV1 isolate with RT 103N, 108I, 181C mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID389379Cytotoxicity against human MT4 cells2008Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
1,2,3-Thiadiazole thioacetanilides as a novel class of potent HIV-1 non-nucleoside reverse transcriptase inhibitors.
AID279506Antiviral activity against HIV1 isolate with RT V106I mutation in Hela-JC-53 cells2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279425Antiviral activity against HIV1 isolate with RT 179G mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279504Inhibition of human DNA polymerase alpha upto 45 uM2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279423Antiviral activity against HIV1 isolate with RT 106I, 188L mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279528Antiviral activity against HIV1 NL4-3 with Y188L mutation in Hela-JC53 cells in the presence of 40% human serum after 48 hrs2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID717255Antiviral activity against HIV1 infected in human MT4 cells assessed as inhibition of virus-induced cytopathicity by MTT assay2012Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23
Structure-based bioisosterism design, synthesis and biological evaluation of novel 1,2,4-triazin-6-ylthioacetamides as potent HIV-1 NNRTIs.
AID279492Antiviral activity against HIV1 isolate with RT K103N-F227L mutation2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279410Antiviral activity against HIV1 isolate with RT 179E mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279428Antiviral activity against HIV1 isolate with RT 101E, 181C mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279491Antiviral activity against HIV1 isolate with RT K101E mutant2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279436Antiviral activity against HIV1 isolate with RT 103R, 179D mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279496Antiviral activity against HIV1 isolate with RT K103N-G190A mutation2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279406Antiviral activity against HIV1 isolate with RT 103N, 238T mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID685330Antiviral activity against HIV-1 RES056 harboring RT K103N/Y181C mutant gene infected human MT4 cells assessed as inhibition in viral syncytium formation by MTT assay2012Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18
Arylazolyl(azinyl)thioacetanilides. Part 10: design, synthesis and biological evaluation of novel substituted imidazopyridinylthioacetanilides as potent HIV-1 inhibitors.
AID389380Selectivity index, ratio of CC50 for human MT4 cells to EC50 for HIV1 3B2008Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
1,2,3-Thiadiazole thioacetanilides as a novel class of potent HIV-1 non-nucleoside reverse transcriptase inhibitors.
AID279419Antiviral activity against HIV1 isolate with RT 101Q, 181C, 190A mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279442Antiviral activity against HIV1 isolate with RT 98G, 190A mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279445Antiviral activity against HIV1 isolate with RT 101E, 103N mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279465Antiviral activity against HIV1 isolate with RT 98G, 103N, 181C, 190A mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279408Antiviral activity against HIV1 isolate with RT 101Q, 103N mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279509Antiviral activity against HIV1 isolate with RT F227L mutation in Hela-JC-53 cells2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279434Antiviral activity against HIV1 isolate with RT 101E, 181C, 190S mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279533AUC in dog at 10 mg/kg, iv2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID718373Antiviral activity against HIV harboring reverse transcriptase K103N/Y181C mutant2012Bioorganic & medicinal chemistry, Dec-01, Volume: 20, Issue:23
Discovery of novel 2-(3-(2-chlorophenyl)pyrazin-2-ylthio)-N-arylacetamides as potent HIV-1 inhibitors using a structure-based bioisosterism approach.
AID279427Antiviral activity against HIV1 isolate with RT 103R, 179D, 188L mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279499Antiviral activity against HIV1 isolate with RT A98G mutation2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279443Antiviral activity against HIV1 isolate with RT 106A, 190A mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279495Antiviral activity against HIV1 isolate with RT K103N-Y188L mutation2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279487Antiviral activity against HIV1 isolate with RT K103N-L100I mutation2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279468Antiviral activity against HIV1 isolate with RT 98G, 108I, 181C mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279396Antiviral activity against HIV1 isolate with RT 103N, 225H mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279530Tmax in dog at 10 mg/kg, iv2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID1235379Cytotoxicity against human MT4 cells assessed as reduction in cell viability incubated for 4 days MTT method2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Hybrid chemistry. Part 4: Discovery of etravirine-VRX-480773 hybrids as potent HIV-1 non-nucleoside reverse transcriptase inhibitors.
AID279535Tmax in dog at 20 mg/kg, po2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID619640Antiviral activity against HIV-1 3B harboring RT K103N and Y181C mutant infected in human MT4 cells assessed as inhibition of virus-induced syncytium formation after 5 days by MTT assay2011European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
Arylazolylthioacetanilide. Part 8: Design, synthesis and biological evaluation of novel 2-(2-(2,4-dichlorophenyl)-2H-1,2,4-triazol-3-ylthio)-N-arylacetamides as potent HIV-1 inhibitors.
AID279401Antiviral activity against HIV1 isolate with RT 181C, 190A mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279456Antiviral activity against HIV1 isolate with RT 188H mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID1235380Selectivity index, ratio of CC50 for human MT4 cells to EC50 for HIV1 3B infected in human MT4 cells2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Hybrid chemistry. Part 4: Discovery of etravirine-VRX-480773 hybrids as potent HIV-1 non-nucleoside reverse transcriptase inhibitors.
AID279532Half life in dog at 10 mg/kg, iv2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID1235376Antiviral activity against HIV1 3B infected in human MT4 cells assessed as inhibition of virus-induced cytopathicity incubated for 4 days by MTT method2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Hybrid chemistry. Part 4: Discovery of etravirine-VRX-480773 hybrids as potent HIV-1 non-nucleoside reverse transcriptase inhibitors.
AID279397Antiviral activity against HIV1 isolate with RT 188L mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279458Antiviral activity against HIV1 isolate with RT 103Q mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279518Antiviral activity against HIV1 NL4-3 in Hela-JC53 cells in the presence of 10% human serum after 48 hrs2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279441Antiviral activity against HIV1 isolate with RT 101Q, 190S mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID1235378Antiviral activity against HIV2 ROD infected in human MT4 cells assessed as inhibition of virus-induced cytopathicity incubated for 4 days by MTT method2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Hybrid chemistry. Part 4: Discovery of etravirine-VRX-480773 hybrids as potent HIV-1 non-nucleoside reverse transcriptase inhibitors.
AID279447Antiviral activity against HIV1 isolate with RT 236L mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279519Antiviral activity against wild type HIV1 NL4-3 in Hela-JC53 cells in the presence of 20% human serum after 48 hrs2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279481Antiviral activity against HIV1 isolate with RT 101E mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279438Antiviral activity against HIV1 isolate with RT 98G, 103N, 108I mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID685331Antiviral activity against HIV-1 3B infected human MT4 cells assessed as inhibition in viral syncytium formation by MTT assay2012Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18
Arylazolyl(azinyl)thioacetanilides. Part 10: design, synthesis and biological evaluation of novel substituted imidazopyridinylthioacetanilides as potent HIV-1 inhibitors.
AID279399Antiviral activity against HIV1 isolate with RT 179D mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279485Antiviral activity against HIV1 isolate with RT K103N-V108I mutation2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279414Antiviral activity against HIV1 isolate with RT 108I, 181C mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279412Antiviral activity against HIV1 isolate with RT 103N, 188L mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279457Antiviral activity against HIV1 isolate with RT 98G, 101E, 181C, 190A mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279522Antiviral activity against wild type HIV1 NL4-3 in Hela-JC53 cells in the presence of 50% human serum after 48 hrs2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279424Antiviral activity against HIV1 isolate with RT 103N, 106A mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279430Antiviral activity against HIV1 isolate with RT 103N, 106I mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279403Antiviral activity against HIV1 isolate with RT 108I mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279389Antiviral activity against HIV1 isolate with RT 103N mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID389378Antiviral activity against HIV1 3B in human MT4 cells assessed as protection of cell against virus-induced cytopathogenicity2008Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
1,2,3-Thiadiazole thioacetanilides as a novel class of potent HIV-1 non-nucleoside reverse transcriptase inhibitors.
AID279503Inhibition of HIV1 reverse transcriptase2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279498Antiviral activity against HIV1 isolate with RT K103N-V108I-A98G mutation2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279536Cmax in dog at 20 mg/kg, po2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279516Antiviral activity against wild type HIV1 NL4-3 in Hela-JC53 cells after 48 hrs2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279501Antiviral activity against HIV1 isolate with RT Y181C mutation2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279524Antiviral activity against HIV1 NL4-3 with Y188L mutation in Hela-JC53 cells in the presence of 5% human serum after 48 hrs2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279392Antiviral activity against HIV1 isolate with RT 100I, 103N mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279426Antiviral activity against HIV1 isolate with RT 227L mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279473Antiviral activity against HIV1 isolate with RT 230L mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279464Antiviral activity against HIV1 isolate with RT 101Q, 103N, 225H mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279451Antiviral activity against HIV1 isolate with RT 101E, 108I, 181C, 190A mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279437Antiviral activity against HIV1 isolate with RT 103N, 108I, 225H mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279390Antiviral activity against HIV1 isolate with RT 103N, 181C mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279417Antiviral activity against HIV1 isolate with RT 106A, F227L mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279420Antiviral activity against HIV1 isolate with RT 190S mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279494Antiviral activity against HIV1 isolate with RT G190A mutation2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279415Antiviral activity against HIV1 isolate with RT 101E, 181C, 190A mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279531Cmax in dog at 10 mg/kg, iv2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279478Antiviral activity against HIV1 isolate with RT 106L, 188L mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279500Antiviral activity against HIV1 isolate with RT V106I mutation2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279502Antiviral activity against wild type HIV12007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279431Antiviral activity against HIV1 isolate with RT 103S, 190A mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279483Antiviral activity against HIV1 isolate with RT K103N-Y181C mutation2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279515Antiviral activity against HIV1 isolate with RT V106I, D123G, Y181C, F227L, T369I mutation in Hela-JC-53 cells2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279537Half life in dog at 20 mg/kg, po2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279488Antiviral activity against HIV1 isolate with RT G190S mutation2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279539Plasma concentration in dog at 20 mg/kg, po after 12 hrs2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279391Antiviral activity against HIV1 isolate with RT 181C mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279461Antiviral activity against HIV1 isolate with RT 179D, 188L mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279475Antiviral activity against HIV1 isolate with RT 101E, 103N, 190A mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279470Antiviral activity against HIV1 isolate with RT 238T mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279523Antiviral activity against HIV1 NL4-3 with Y188L mutation in Hela-JC53 cells after 48 hrs2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279477Antiviral activity against HIV1 isolate with RT 181V mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279510Antiviral activity against HIV1 isolate with RT T369I mutation in Hela-JC-53 cells2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279407Antiviral activity against HIV1 isolate with RT 98G, 103N mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279444Antiviral activity against HIV1 isolate with RT 101Q, 181C, 190S mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279508Antiviral activity against HIV1 isolate with RT Y181C mutation in Hela-JC-53 cells2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279454Antiviral activity against HIV1 isolate with RT 100I, 103N, 108I mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID718374Antiviral activity against wild type HIV2012Bioorganic & medicinal chemistry, Dec-01, Volume: 20, Issue:23
Discovery of novel 2-(3-(2-chlorophenyl)pyrazin-2-ylthio)-N-arylacetamides as potent HIV-1 inhibitors using a structure-based bioisosterism approach.
AID279520Antiviral activity against wild type HIV1 NL4-3 in Hela-JC53 cells in the presence of 30% human serum after 48 hrs2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279527Antiviral activity against HIV1 NL4-3 with Y188L mutation in Hela-JC53 cells in the presence of 30% human serum after 48 hrs2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279413Antiviral activity against HIV1 isolate with RT 106A mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279541Inhibition of hepatitis B virus replication2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279525Antiviral activity against HIV1 NL4-3 with Y188L mutation in Hela-JC53 cells in the presence of 10% human serum after 48 hrs2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279545Inhibition of non-B HIV1 isolates (clades A, AC, C, D and F)2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279472Antiviral activity against HIV1 isolate with RT 103S mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID619629Antiviral activity against HIV-1 3B infected in human MT4 cells assessed as inhibition of virus-induced syncytium formation after 5 days by MTT assay2011European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
Arylazolylthioacetanilide. Part 8: Design, synthesis and biological evaluation of novel 2-(2-(2,4-dichlorophenyl)-2H-1,2,4-triazol-3-ylthio)-N-arylacetamides as potent HIV-1 inhibitors.
AID279512Antiviral activity against HIV1 isolate with RT V106I, Y181C, F227L mutation in Hela-JC-53 cells2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279400Antiviral activity against HIV1 isolate with RT 190A mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279432Antiviral activity against HIV1 isolate with RT 181I mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279449Antiviral activity against HIV1 isolate with RT 98G, 188L mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279452Antiviral activity against HIV1 isolate with RT 103N, 108I, 238T mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279404Antiviral activity against HIV1 isolate with RT 103N, 181C, 190A mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279505Inhibition of human DNA polymerase beta upto 45 uM2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279416Antiviral activity against HIV1 isolate with RT 179A mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279409Antiviral activity against HIV1 isolate with RT 101P, 103N mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279429Antiviral activity against HIV1 isolate with RT 103N, 106M mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279474Antiviral activity against HIV1 isolate with RT 101R, 103N, 181C, 190A mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279439Antiviral activity against HIV1 isolate with RT 101P, 190A mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279460Antiviral activity against HIV1 isolate with RT 103N, 108I, 181C, 190A mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279513Antiviral activity against HIV1 isolate with RT V106I, Y181C, F227L, T369I mutation in Hela-JC-53 cells2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279484Antiviral activity against HIV1 isolate with RT K103N-P225H mutation2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279514Antiviral activity against HIV1 isolate with RT V106I, D123G, Y181C, F227L mutation in Hela-JC-53 cells2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279486Antiviral activity against HIV1 isolate with RT K103N-K101Q mutation2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279459Antiviral activity against HIV1 isolate with RT 101H mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279395Antiviral activity against HIV1 isolate with RT 101Q mutation relative to wild type2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
AID279529Antiviral activity against HIV1 NL4-3 with Y188L mutation in Hela-JC53 cells in the presence of 50% human serum after 48 hrs2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (20.00)29.6817
2010's7 (70.00)24.3611
2020's1 (10.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.40

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.40 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.80 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.40)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
acetanilide
acetanilide: a phenylacetamide; use ACETANILIDES for the plural group meaning of the singular term. N-phenylacetamide : A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen is substituted by a phenyl group.		2.1110acetamides;
anilide		analgesic
nevirapine
Nevirapine: A potent, non-nucleoside reverse transcriptase inhibitor used in combination with nucleoside analogues for treatment of HIV INFECTIONS and AIDS.. nevirapine : A dipyridodiazepine that is 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine which is substituted by methyl, oxo, and cyclopropyl groups at positions 4, 6, and 11, respectively. A non-nucleoside reverse transcriptase inhibitor with activity against HIV-1, it is used in combination with other antiretrovirals for the treatment of HIV infection.		3.5880cyclopropanes;
dipyridodiazepine		antiviral drug;
HIV-1 reverse transcriptase inhibitor
delavirdine
Delavirdine: A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1.. delavirdine : The amide resulting from the formal condensation of 5-[(methylsulfonyl)amino]-1H-indole-2-carboxylic acid and 4-amino group of 1-[3-(isopropylamino)pyridin-2-yl]piperazine, delavirdine is a non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. Viral resistance emerges rapidly when delavirdine is used alone, so it is therefore used (as the methanesulfonic acid salt) with other antiretrovirals for combination therapy of HIV infection.		3.1750aminopyridine;
indolecarboxamide;
N-acylpiperazine;
sulfonamide		antiviral drug;
HIV-1 reverse transcriptase inhibitor
zalcitabine
Zalcitabine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.. zalcitabine : A pyrimidine 2',3'-dideoxyribonucleoside compound having cytosine as the nucleobase.		2.9940pyrimidine 2',3'-dideoxyribonucleosideantimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
zidovudine
Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.. zidovudine : A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.		3.1650azide;
pyrimidine 2',3'-dideoxyribonucleoside		antimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
efavirenz
efavirenz: HIV-1 reverse transcriptase inhibitor. efavirenz : 1,4-Dihydro-2H-3,1-benzoxazin-2-one substituted at the 4 position by cyclopropylethynyl and trifluoromethyl groups (S configuration) and at the 6 position by chlorine. A non-nucleoside reverse transcriptase inhibitor with activity against HIV, it is used with other antiretrovirals for combination therapy of HIV infection.		3.5880acetylenic compound;
benzoxazine;
cyclopropanes;
organochlorine compound;
organofluorine compound		antiviral drug;
HIV-1 reverse transcriptase inhibitor
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		2.75301,2,3-triazole
etravirine
[no description available]		7.8130aminopyrimidine;
aromatic ether;
dinitrile;
organobromine compound		antiviral agent;
HIV-1 reverse transcriptase inhibitor
delavirdine mesylate
delavirdine mesylate : The monomethanesulfonic acid salt of delavirdine, a non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. Viral resistance emerges rapidly when delavirdine is used alone, so it is therefore used (as the methanesulfonic acid salt) with other antiretrovirals for combination therapy of HIV infection.		2.0610methanesulfonate saltantiviral drug;
HIV-1 reverse transcriptase inhibitor
didanosine
Didanosine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.. didanosine : A purine 2',3'-dideoxyribonucleoside that is inosine in which the hydroxy groups at both the 2' and the 3' positions on the sugar moiety have been replaced by hydrogen. An antiviral drug, it is used as a medication to treat HIV/AIDS.		2.0610purine 2',3'-dideoxyribonucleosideantimetabolite;
antiviral drug;
EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor;
geroprotector;
HIV-1 reverse transcriptase inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
HIV Coinfection
[description not available]		03.1550
HIV Infections
Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).		03.1550