triazoles has been researched along with loreclezole in 60 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 35 (58.33) | 18.2507 |
| 2000's | 23 (38.33) | 29.6817 |
| 2010's | 1 (1.67) | 24.3611 |
| 2020's | 1 (1.67) | 2.80 |
| Authors | Studies |
|---|---|
| Meert, TF | 1 |
| Heinemann, U; Zhang, CL | 1 |
| Ates, N; Coenen, AM; Drinkenburg, WH; van Luijtelaar, EL; Vossen, JM | 1 |
| Ashton, D; Clincke, GH; Fransen, J; Heeres, J; Janssen, PA | 1 |
| Hulsman, JA; Rentmeester, TW | 1 |
| Ashton, D; Willems, R | 1 |
| De Beukelaar, F; Tritsmans, L | 1 |
| Hulsman, J; Rentmeester, T | 1 |
| Raffa, RB; Setler, PE; Vaught, JL | 1 |
| De Beukelaar, F; Overweg, J | 1 |
| Dailey, JW; Jo, M; Jobe, PC; Ko, KH; Seo, DO; Yan, QS | 1 |
| Bayley, P; Curnow, R; Dawson, GR; Rambridge, A; Tricklebank, MD | 1 |
| Bain, CJ; Kemp, JA; McKernan, RM; Quirk, K; Wafford, KA; Whiting, PJ; Wingrove, PB | 1 |
| Bain, C; Wafford, KA; Whiting, PJ; Wingrove, PB | 1 |
| Biggio, G; Ghiani, CA; Maciocco, E; Sanna, E; Serra, M; Tuligi, G | 1 |
| Friend, JM; Gee, KW; Xue, BG | 1 |
| Kapur, J; Macdonald, RL | 3 |
| Stevenson, A; Wafford, KA; Whiting, PJ; Wingrove, PB | 1 |
| Bracamontes, J; Steinbach, JH; Ueno, S; Zorumski, C | 1 |
| Korpi, ER; Matecka, D; Sarviharju, M; Toropainen, M; Wong, G | 1 |
| Hosie, AM; Sattelle, DB | 1 |
| Donnelly, JL; MacDonald, RL | 1 |
| Cross, AJ; Green, AR; Misra, A; Murray, TK; Snape, MF | 1 |
| Biggio, G; Casula, A; Maciocco, E; Murgia, A; Sanna, E; Tuligi, G; Usala, M | 1 |
| Simmonds, MA; Zhong, Y | 1 |
| Greenfield, LJ; Macdonald, RL; Neelands, TR; Turner, RS; Zhang, J | 1 |
| Bianchi, M; Fisher, JL; Macdonald, RL; Neelands, TR | 1 |
| Davies, CH; Manuel, NA | 1 |
| Korpi, ER; Mäkelä, R; Wisden, W | 1 |
| Kapur, J; Macdonald, RL; Tietz, EI | 1 |
| Macdonald, RL; Neelands, TR; Zhang, J | 1 |
| Halliwell, RF; James, CH; Martinez-Torres, A; Miledi, R; Patten, D; Smart, TG; Thomas, P | 1 |
| Macdonald, RL; Neelands, TR | 1 |
| Fisher, JL; Hinkle, DJ; Macdonald, RL | 1 |
| Carlisle, HJ; Davies, PA; Hales, TG; Hoffmann, EB; Tyndale, RF | 1 |
| Maksay, G; Thompson, SA; Wafford, KA | 1 |
| Sapp, DW; Yeh, HH | 1 |
| Saxena, NC | 1 |
| Feigenspan, A; Gustincich, S; Raviola, E | 1 |
| Baur, R; Dodd, RH; Furtmüller, R; Razet, R; Sieghart, W; Sigel, E; Thomet, U | 1 |
| Baur, R; Dodd, RH; Sigel, E; Thomet, U | 1 |
| Hevers, W; Korpi, ER; Lüddens, H | 1 |
| Holopainen, IE; Kivelä, R; Korpi, ER | 1 |
| Abouabdellah, A; Baur, R; Dodd, RH; El Hadri, A; Furtmüller, R; Sieghart, W; Sigel, E; Thomet, U | 1 |
| Dillon, GH; Huang, RQ | 1 |
| Atack, J; Belelli, D; Cirone, J; Dawson, GR; Hadingham, KL; Haythornthwaite, A; Howell, O; Hutson, PH; Lambert, JJ; Macaulay, AJ; McKernan, R; Myers, J; Newman, RJ; O'Meara, GF; Reynolds, DS; Rosahl, TW; Rutter, AR; Sur, C; Wafford, KA; Whiting, PJ | 1 |
| Bacci, A; Huguenard, JR; Prince, DA; Rudolph, U | 1 |
| Borowicz, KK; Czuczwar, SJ; Sawiniec, A | 1 |
| DuBois, DW; Frye, GD; Hsiao, SH; Miranda, RC | 1 |
| Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N | 3 |
| Kapur, J; Mtchedlishvili, Z | 1 |
| Baur, R; Boulineau, N; Minier, F; Sigel, E | 1 |
| Huguenard, JR; Huntsman, MM | 1 |
| Davies, A; Groves, JO; Guscott, MR; Hallett, DJ; Pike, A; Reynolds, DS; Rosahl, TW; Wafford, KA | 1 |
| Simeone, TA; White, HS; Wilcox, KS | 1 |
| Enz, D; Ernst, M; Heider, J; Koniuszewski, F; Langer, T; Miele, M; Monticelli, S; Pace, V; Scholze, P; Seidel, T; Simeone, X; Vogel, FD | 1 |
3 review(s) available for triazoles and loreclezole
| Article | Year |
|---|---|
Application of drug discrimination with drugs of abuse to develop new therapeutic agents.
Topics: Animals; Antipsychotic Agents; Discrimination Learning; Humans; Illicit Drugs; Ritanserin; Triazoles | 1991 |
Loreclezole.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drugs, Investigational; Electroencephalography; Epilepsy; Evoked Potentials; Humans; Triazoles | 1991 |
Pharmacological properties of recombinant and hippocampal dentate granule cell GABAA receptors.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Electric Conductivity; Electrophysiology; GABA-A Receptor Antagonists; Humans; Pyridines; Receptors, GABA-A; Recombinant Proteins; Triazoles; Zinc; Zolpidem | 1999 |
57 other study(ies) available for triazoles and loreclezole
| Article | Year |
|---|---|
Effects of the triazole derivative loreclezole (R72063) on stimulus induced ionic and field potential responses and on different patterns of epileptiform activity induced by low magnesium in rat entorhinal cortex-hippocampal slices.
Topics: Animals; Anticonvulsants; Calcium; Cerebral Cortex; Epilepsy; Evoked Potentials; Female; Hippocampus; In Vitro Techniques; Magnesium; Rats; Rats, Wistar; Triazoles | 1992 |
Effects of loreclezole on epileptic activity and on EEG and behaviour in rats with absence seizures.
Topics: Animals; Anticonvulsants; Behavior, Animal; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, Absence; Exploratory Behavior; Female; Male; Rats; Rats, Inbred Strains; Triazoles | 1992 |
In vivo studies on the mechanism of action of the broad spectrum anticonvulsant loreclezole.
Topics: Animals; Anticonvulsants; Diazepam; Electric Stimulation; Kindling, Neurologic; Male; Pentobarbital; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Triazoles | 1992 |
Loreclezole monotherapy in patients with partial seizures.
Topics: Anticonvulsants; Epilepsies, Partial; Female; Humans; Male; Substance Withdrawal Syndrome; Triazoles; Valproic Acid | 1992 |
In vitro studies on the broad spectrum anticonvulsant loreclezole in the hippocampus.
Topics: Animals; Anticonvulsants; Calcium; Electric Stimulation; Epilepsy; Etomidate; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Magnesium Deficiency; Pentobarbital; Phenobarbital; Triazoles | 1992 |
Efficacy and safety evaluation of loreclezole as add-on treatment in therapy-resistant epilepsy patients.
Topics: Adult; Anticonvulsants; Drug Resistance; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Middle Aged; Triazoles | 1991 |
The novel anticonvulsant loreclezole (R 72063) does not produce diazepam-like anterograde amnesia in a passive avoidance test in rats.
Topics: Amnesia; Animals; Anticonvulsants; Avoidance Learning; Diazepam; Male; Rats; Rats, Inbred Strains; Scopolamine; Triazoles | 1990 |
Single-dose efficacy evaluation of loreclezole in patients with photosensitive epilepsy.
Topics: Adult; Anticonvulsants; Drug Administration Schedule; Epilepsy; Female; Humans; Male; Molecular Structure; Photic Stimulation; Triazoles | 1990 |
The anticonvulsant effect of the broad spectrum anticonvulsant loreclezole may be mediated in part by serotonin in rats: a microdialysis study.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Genetic Predisposition to Disease; Hydroxyindoleacetic Acid; Microdialysis; Rats; Rats, Sprague-Dawley; Serotonin; Triazoles | 1994 |
Lack of effect of flumazenil and CGS 8216 on the anxiolytic-like properties of loreclezole.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Convulsants; Drug Interactions; Flumazenil; Injections, Intraperitoneal; Male; Pyrazoles; Rats; Triazoles | 1994 |
A novel allosteric modulatory site on the GABAA receptor beta subunit.
Topics: Allosteric Site; Animals; Anticonvulsants; Cells, Cultured; Chlorides; Drug Synergism; Electric Conductivity; Electrophysiology; Female; gamma-Aminobutyric Acid; Gene Expression; Humans; Pentobarbital; Pregnanolone; Rats; Receptors, GABA; Transfection; Triazoles; Xenopus | 1994 |
The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit.
Topics: Allosteric Site; Amino Acid Sequence; Animals; Anticonvulsants; Base Sequence; DNA Primers; DNA, Complementary; Dose-Response Relationship, Drug; Female; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Macromolecular Substances; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Point Mutation; Polymerase Chain Reaction; Receptors, GABA-A; Recombinant Fusion Proteins; Triazoles; Xenopus | 1994 |
Biochemical evaluations of the effects of loreclezole and propofol on the GABAA receptor in rat brain.
Topics: Anesthetics; Animals; Anticonvulsants; Brain; Bridged Bicyclo Compounds, Heterocyclic; Diazepam; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Hypnotics and Sedatives; In Vitro Techniques; Male; Muscimol; Pentobarbital; Pregnanediones; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sulfur Radioisotopes; Triazoles; Tritium | 1996 |
Loreclezole modulates [35S]t-butylbicyclophosphorothionate and [3H]flunitrazepam binding via a distinct site on the GABAA receptor complex.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Drug Interactions; Flunitrazepam; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA; Triazoles | 1996 |
Pharmacological properties of gamma-aminobutyric acidA receptors from acutely dissociated rat dentate granule cells.
Topics: Allosteric Regulation; Animals; Anticonvulsants; Carbolines; Chlorides; Convulsants; Dentate Gyrus; Diazepam; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Hypnotics and Sedatives; In Vitro Techniques; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Triazoles; Zinc Compounds; Zolpidem | 1996 |
beta-Carboline gamma-aminobutyric acidA receptor inverse agonists modulate gamma-aminobutyric acid via the loreclezole binding site as well as the benzodiazepine site.
Topics: Animals; Anticonvulsants; Benzodiazepines; Binding Sites; Carbolines; Convulsants; Drug Synergism; Female; GABA Agonists; gamma-Aminobutyric Acid; Isomerism; Macromolecular Substances; Oocytes; Point Mutation; Receptors, GABA; Triazoles; Xenopus | 1995 |
Endogenous subunits can cause ambiguities in the pharmacology of exogenous gamma-aminobutyric acidA receptors expressed in human embryonic kidney 293 cells.
Topics: Amino Acid Sequence; Anticonvulsants; Cells, Cultured; Drug Synergism; Embryo, Mammalian; Humans; Kidney; Molecular Sequence Data; Receptors, GABA-A; Transfection; Triazoles | 1996 |
Pharmacologic actions of subtype-selective and novel GABAergic ligands in rat lines with differential sensitivity to ethanol.
Topics: Animals; Autoradiography; Binding, Competitive; Diazepam; Dose-Response Relationship, Drug; Ethanol; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Male; Motor Activity; Pyridines; Rats; Triazoles; Zolpidem | 1996 |
Allosteric modulation of an expressed homo-oligomeric GABA-gated chloride channel of Drosophila melanogaster.
Topics: Allosteric Regulation; Animals; Chloride Channels; Dose-Response Relationship, Drug; Drosophila melanogaster; GABA Modulators; gamma-Aminobutyric Acid; Patch-Clamp Techniques; Pregnanolone; Receptors, GABA; Triazoles; Xenopus | 1996 |
Loreclezole enhances apparent desensitization of recombinant GABAA receptor currents.
Topics: Animals; Anticonvulsants; Cell Line; Cerebral Cortex; Electrophysiology; Fibroblasts; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Membrane Potentials; Mice; Patch-Clamp Techniques; Recombinant Proteins; Triazoles | 1996 |
A behavioural and neurochemical study in rats of the pharmacology of loreclezole, a novel allosteric modulator of the GABAA receptor.
Topics: Allosteric Regulation; Animals; Behavior, Animal; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlormethiazole; Dose-Response Relationship, Drug; GABA Modulators; Hypnotics and Sedatives; Male; Muscle Relaxation; Pentobarbital; Picrotoxin; Rats; Receptors, GABA-A; Seizures; Sesterterpenes; Triazoles | 1996 |
Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit.
Topics: Animals; Anticonvulsants; Bicuculline; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebral Cortex; Chloride Channels; Convulsants; Diazepam; DNA, Complementary; Female; gamma-Aminobutyric Acid; Humans; Kinetics; Macromolecular Substances; Male; Membrane Potentials; Oocytes; Picrotoxin; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recombinant Proteins; Triazoles; Xenopus laevis | 1996 |
Interactions between loreclezole, chlormethiazole and pentobarbitone at GABA(A) receptors: functional and binding studies.
Topics: Animals; Anticonvulsants; Bicuculline; Chlormethiazole; Flunitrazepam; In Vitro Techniques; Male; Medulla Oblongata; Pentobarbital; Rats; Rats, Wistar; Receptors, GABA-A; Triazoles | 1997 |
GABAA receptor pharmacology and subtype mRNA expression in human neuronal NT2-N cells.
Topics: Anticonvulsants; Bicuculline; Carbolines; Convulsants; Diazepam; Diuretics; DNA Primers; Furosemide; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Hypnotics and Sedatives; Lanthanum; Neurons; Patch-Clamp Techniques; Pentobarbital; Phenobarbital; Picrotoxin; Polymerase Chain Reaction; Pregnanediones; Pregnenolone; Pyridines; Receptors, GABA-A; RNA, Messenger; Teratocarcinoma; Triazoles; Tumor Cells, Cultured; Zinc; Zolpidem | 1998 |
Spontaneous and gamma-aminobutyric acid (GABA)-activated GABA(A) receptor channels formed by epsilon subunit-containing isoforms.
Topics: Animals; Cell Line; Dose-Response Relationship, Drug; Furosemide; gamma-Aminobutyric Acid; Lanthanum; Mice; Pentobarbital; Protein Isoforms; Rats; Receptors, GABA-A; Triazoles; Zinc | 1999 |
Pharmacological modulation of GABA(A) receptor-mediated postsynaptic potentials in the CA1 region of the rat hippocampus.
Topics: Animals; Anticonvulsants; Barbiturates; Benzodiazepines; Hippocampus; In Vitro Techniques; Rats; Rats, Wistar; Receptors, GABA-A; Synaptic Transmission; Triazoles; Zinc | 1998 |
Postnatal development of hippocampal dentate granule cell gamma-aminobutyric acidA receptor pharmacological properties.
Topics: Animals; Benzodiazepines; Dentate Gyrus; Electrophysiology; Furosemide; In Vitro Techniques; Rats; Receptors, GABA-A; Triazoles; Zinc | 1999 |
Loreclezole and La3+ differentiate cerebellar granule cell GABA(A) receptor subtypes.
Topics: Animals; Anticonvulsants; Autoradiography; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; gamma-Aminobutyric Acid; In Vitro Techniques; Lanthanum; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mutation; Radioligand Assay; Receptors, GABA-A; Sulfur Radioisotopes; Triazoles | 1999 |
Functional GABAA receptor heterogeneity of acutely dissociated hippocampal CA1 pyramidal cells.
Topics: Allosteric Regulation; Animals; Anticonvulsants; Carbolines; Convulsants; Diazepam; Dose-Response Relationship, Drug; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Hypnotics and Sedatives; Membrane Potentials; Patch-Clamp Techniques; Pyramidal Cells; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Triazoles; Zinc; Zolpidem | 1999 |
GABA(A) receptors expressed in undifferentiated human teratocarcinoma NT2 cells differ from those expressed by differentiated NT2-N cells.
Topics: Anti-Anxiety Agents; Anticonvulsants; Cell Differentiation; Diazepam; Furosemide; Humans; Lanthanum; Neurons; Patch-Clamp Techniques; Pyridines; Receptors, GABA-A; Teratocarcinoma; Triazoles; Tumor Cells, Cultured; Zinc; Zolpidem | 1999 |
Subunit-selective modulation of GABAA receptors by the non-steroidal anti-inflammatory agent, mefenamic acid.
Topics: Amino Acid Sequence; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Electric Conductivity; Electrophysiology; Etomidate; Humans; Mefenamic Acid; Models, Molecular; Molecular Conformation; Oocytes; Protein Isoforms; Receptors, GABA-A; Recombinant Proteins; Triazoles; Xenopus laevis | 1999 |
Incorporation of the pi subunit into functional gamma-aminobutyric Acid(A) receptors.
Topics: Animals; Barbiturates; Benzodiazepines; Cells, Cultured; Dose-Response Relationship, Drug; Electrophysiology; gamma-Aminobutyric Acid; Lanthanum; Mice; Rats; Receptors, GABA-A; Recombinant Fusion Proteins; Steroids; Triazoles; Zinc | 1999 |
Loreclezole inhibition of recombinant alpha1beta1gamma2L GABA(A) receptor single channel currents.
Topics: Animals; Anticonvulsants; Brain; Cells, Cultured; Cytoplasm; Electrophysiology; GABA Modulators; GABA-A Receptor Antagonists; Humans; Kinetics; Membrane Potentials; Mice; Patch-Clamp Techniques; Protein Isoforms; Rats; Receptors, GABA-A; Recombinant Proteins; Triazoles | 2000 |
The influence of an endogenous beta3 subunit on recombinant GABA(A) receptor assembly and pharmacology in WSS-1 cells and transiently transfected HEK293 cells.
Topics: Animals; Cell Line; Diazepam; GABA Modulators; Humans; Mice; Patch-Clamp Techniques; Receptors, GABA-A; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transfection; Triazoles | 2000 |
Allosteric modulators affect the efficacy of partial agonists for recombinant GABA(A) receptors.
Topics: Allosteric Regulation; Animals; Barbiturates; Benzodiazepines; Dose-Response Relationship, Drug; GABA Agonists; GABA-A Receptor Agonists; Humans; Oocytes; Receptors, GABA-A; Recombinant Proteins; Triazoles; Xenopus laevis | 2000 |
Heterogeneity of GABA(A) receptor-mediated responses in the human IMR-32 neuroblastoma cell line.
Topics: Anticonvulsants; Bicuculline; Diazepam; Dose-Response Relationship, Drug; GABA Modulators; gamma-Aminobutyric Acid; Humans; Neuroblastoma; Patch-Clamp Techniques; Pentobarbital; Pregnanolone; Protein Isoforms; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Triazoles; Tumor Cells, Cultured; Zinc | 2000 |
Inhibition of GABA(A) receptor (GABAR) currents by arachidonic acid in HEK 293 cells stably transfected with alpha1beta2gamma2 GABAR subunits.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Anticonvulsants; Arachidonic Acid; Binding, Competitive; Cells, Cultured; Cyclooxygenase Inhibitors; Diazepam; Dose-Response Relationship, Drug; Fatty Acids; Fatty Acids, Monounsaturated; GABA Antagonists; GABA Modulators; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Indomethacin; Kidney; Linoleic Acid; Masoprocol; Membrane Potentials; Patch-Clamp Techniques; Pentobarbital; Picrotoxin; Receptors, GABA-A; Recombinant Proteins; Transfection; Triazoles | 2000 |
Pharmacology of GABA(A) receptors of retinal dopaminergic neurons.
Topics: Alkaline Phosphatase; Animals; Benzodiazepines; Bicuculline; Binding Sites; Dopamine; Dose-Response Relationship, Drug; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Mice; Mice, Transgenic; Neurons; Osmolar Concentration; Patch-Clamp Techniques; Picrotoxin; Pregnanediones; Protein Isoforms; Receptors, GABA-A; Retina; Sesterterpenes; Triazoles; Zinc | 2000 |
A novel positive allosteric modulator of the GABA(A) receptor: the action of (+)-ROD188.
Topics: Action Potentials; Allosteric Regulation; Animals; Benzodiazepines; Cells, Cultured; Female; Furans; GABA Modulators; Hippocampus; Humans; Isoquinolines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Tetrahydroisoquinolines; Triazoles; Xenopus laevis | 2000 |
Loreclezole as a simple functional marker for homomeric rho type GABA(C) receptors.
Topics: Animals; Anticonvulsants; gamma-Aminobutyric Acid; Membrane Potentials; Receptors, GABA; Receptors, GABA-B; Triazoles; Xenopus | 2000 |
Assembly of functional alpha6beta3gamma2delta GABA(A) receptors in vitro.
Topics: Affinity Labels; Anesthetics; Animals; Anticonvulsants; Azides; Benzodiazepines; Binding Sites; Cells, Cultured; Desoxycorticosterone; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Membrane Potentials; Muscimol; Protein Structure, Tertiary; Rats; Receptors, GABA-A; Transfection; Triazoles; Tritium | 2000 |
Do antiepileptics phenytoin, carbamazepine, and loreclezole show GABA(A) receptor subtype selectivity in rat brain sections?
Topics: Animals; Anticonvulsants; Autoradiography; Brain; Bridged Bicyclo Compounds, Heterocyclic; Carbamazepine; In Vitro Techniques; Male; Phenytoin; Protein Isoforms; Rats; Rats, Wistar; Receptors, GABA-A; Triazoles | 2001 |
N-Substituted 4-amino-3,3-dipropyl-2(3H)-furanones: new positive allosteric modulators of the GABA(A) receptor sharing electrophysiological properties with the anticonvulsant loreclezole.
Topics: Allosteric Regulation; Animals; Anticonvulsants; Binding, Competitive; Brain; Electricity; Furans; In Vitro Techniques; Lactones; Oocytes; Patch-Clamp Techniques; Radioligand Assay; Rats; Receptors, GABA-A; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Triazoles; Xenopus laevis | 2002 |
Functional characterization of GABA(A) receptors in neonatal hypothalamic brain slice.
Topics: Anesthetics; Animals; Animals, Newborn; Anticonvulsants; Carbolines; Convulsants; Dehydroepiandrosterone Sulfate; Diazepam; Diuretics; Female; Furosemide; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Hypothalamus; Male; Membrane Potentials; Organ Culture Techniques; Patch-Clamp Techniques; Picrotoxin; Pregnanolone; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Triazoles; Zinc; Zolpidem | 2002 |
Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms.
Topics: Anesthetics; Animals; Anticonvulsants; Behavior, Animal; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cell Separation; Consciousness; Dose-Response Relationship, Drug; Electroencephalography; Etomidate; Gene Targeting; Hypnotics and Sedatives; In Vitro Techniques; Male; Mice; Mice, Mutant Strains; Motor Activity; Patch-Clamp Techniques; Protein Isoforms; Purkinje Cells; Receptors, GABA-A; Recovery of Function; Triazoles | 2003 |
Major differences in inhibitory synaptic transmission onto two neocortical interneuron subclasses.
Topics: Action Potentials; Animals; GABA Agonists; gamma-Aminobutyric Acid; Gene Targeting; In Vitro Techniques; Interneurons; Mice; Mice, Mutant Strains; Neocortex; Neural Inhibition; Patch-Clamp Techniques; Protein Subunits; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Somatosensory Cortex; Synaptic Transmission; Triazoles; Zolpidem | 2003 |
Interaction of loreclezole with conventional antiepileptic drugs in amygdala-kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Avoidance Learning; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Kindling, Neurologic; Male; Psychomotor Performance; Rats; Rats, Wistar; Reaction Time; Seizures; Triazoles | 2004 |
Critically timed ethanol exposure reduces GABAAR function on septal neurons developing in vivo but not in vitro.
Topics: Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Bicuculline; Body Weight; Cells, Cultured; Central Nervous System Depressants; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Embryo, Mammalian; Ethanol; Female; GABA Agonists; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Penicillins; Picrotoxin; Pregnancy; Protein Synthesis Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Septum of Brain; Streptomycin; Time Factors; Triazoles; Up-Regulation; Zinc; Zolpidem | 2004 |
Pharmacodynamic and pharmacokinetic interaction studies of loreclezole with felbamate, lamotrigine, topiramate, and oxcarbazepine in the mouse maximal electroshock seizure model.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Electroshock; Felbamate; Fructose; Kindling, Neurologic; Lamotrigine; Male; Mice; Motor Activity; Oxcarbazepine; Phenylcarbamates; Propylene Glycols; Seizures; Topiramate; Triazines; Triazoles | 2005 |
Pharmacodynamic and/or pharmacokinetic characteristics of interactions between loreclezole and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis.
Topics: Animals; Anticonvulsants; Clonazepam; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Ethosuximide; Kindling, Neurologic; Linear Models; Male; Mice; Pentylenetetrazole; Phenobarbital; Seizures; Triazoles; Valproic Acid | 2005 |
High-affinity, slowly desensitizing GABAA receptors mediate tonic inhibition in hippocampal dentate granule cells.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Diazepam; Diuretics; Furosemide; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; Male; Neural Inhibition; Penicillins; Pyridines; Rats; Rats, Sprague-Dawley; Triazoles; Zolpidem | 2006 |
Consequence of the presence of two different beta subunit isoforms in a GABA(A) receptor.
Topics: Animals; DNA; Dose-Response Relationship, Drug; Electrophysiology; Etomidate; GABA Agonists; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Isomerism; Membrane Potentials; Oocytes; Patch-Clamp Techniques; Rats; Receptors, GABA-A; Triazoles; Xenopus | 2005 |
Fast IPSCs in rat thalamic reticular nucleus require the GABAA receptor beta1 subunit.
Topics: Animals; Clonazepam; Electrophysiology; Excitatory Postsynaptic Potentials; Female; GABA Modulators; Intralaminar Thalamic Nuclei; Male; Neurons; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Synapses; Triazoles | 2006 |
Isobolographic analysis of interactions between loreclezole and conventional antiepileptic drugs in the mouse maximal electroshock-induced seizure model.
Topics: Algorithms; Animals; Anticonvulsants; Avoidance Learning; Brain; Drug Interactions; Dyskinesia, Drug-Induced; Electroshock; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Male; Memory; Mice; Psychomotor Performance; Seizures; Triazoles | 2006 |
The role of GABAbeta2 subunit-containing receptors in mediating the anticonvulsant and sedative effects of loreclezole.
Topics: Animals; Anticonvulsants; Female; Hypnotics and Sedatives; Male; Mice; Mice, Mutant Strains; Point Mutation; Receptors, GABA; Receptors, GABA-A; Triazoles | 2006 |
Topiramate modulation of β(1)- and β(3)-homomeric GABA(A) receptors.
Topics: Animals; Drug Interactions; Electrophysiological Phenomena; Fructose; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Inhibitory Concentration 50; Membrane Potentials; Oocytes; Pentobarbital; Picrotoxin; Rats; Receptors, GABA-A; Topiramate; Transfection; Triazoles; Xenopus laevis | 2011 |
Novel alpha6 preferring GABA-A receptor ligands based on loreclezole.
Topics: Allosteric Regulation; Humans; Ligands; Patch-Clamp Techniques; Protein Conformation; Receptors, GABA-A; Triazoles | 2022 |