Compounds > nebularine
Page last updated: 2024-09-23

nebularine

Description

nebularine: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

nebularine : A purine ribonucleoside that is 9H-purine attached to a beta-D-ribofuranosyl residue at position 9 via a glycosidic (N-glycosyl) linkage. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID68368
CHEMBL ID1399702
CHEBI ID18255
SCHEMBL ID93409
MeSH IDM0046656

Synonyms (48)

Synonym
bdbm50335291
9-(beta-d-ribofuranosyl)-9h-purine
CHEBI:18255 ,
EU-0100423
purine nucleoside
9h-purine, 9-beta-d-ribofuranosyl-
einecs 208-981-9
brn 0091539
9h-purine, 9beta-d-ribofuranosyl-
LOPAC0_000423
(2r,3s,4r,5r)-2-(hydroxymethyl)-5-purin-9-yl-tetrahydrofuran-3,4-diol
nebularine
550-33-4
C01736
n-d-ribosylpurine
DB04440
NCGC00093846-02
NCGC00093846-01
NCGC00093846-03
D 8296
NCGC00093846-04
CHEMBL1399702 ,
HMS3261E08
4-26-00-01740 (beilstein handbook reference)
b8b604ps4p ,
unii-b8b604ps4p
CCG-204515
LP00423
nebularine [mi]
SCHEMBL93409
(2r,3s,4r,5r)-2-(hydroxymethyl)-5-(9h-purin-9-yl)-tetrahydrofuran-3,4-diol;nsc 65423;nebularine;purinosine;nsc65423;st055522
(2r,3s,4r,5r)-2-(hydroxymethyl)-5-(9h-purin-9-yl)tetrahydrofuran-3,4-diol
NCGC00261108-01
tox21_500423
MRWXACSTFXYYMV-FDDDBJFASA-N
HB3992
AKOS027327572
9-(beta-d-ribofuranosyl)-9h-purine; 6-deaminoadenosine
mfcd00022819
sr-01000075836
SR-01000075836-1
(2r,3s,4r,5r)-2-(hydroxymethyl)-5-(9h-purin-9-yl)oxolane-3,4-diol
Q3874106
AS-35125
DTXSID701015580
SDCCGSBI-0050408.P002
EN300-7400810
Z3002630759

Roles (1)

RoleDescription
fungal metaboliteAny eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
purine ribonucleosideA ribonucleoside that has a purine moiety as the nucleobase (the R group in the illustration).
purines D-ribonucleosideA purine ribonucleoside that is a purine derivative attached to a beta-D-ribofuranosyl residue at position 9 via a glycosidic (N-glycosyl) linkage.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (18)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency12.58930.003245.467312,589.2998AID2517
ATAD5 protein, partialHomo sapiens (human)Potency29.08100.004110.890331.5287AID493107
TDP1 proteinHomo sapiens (human)Potency0.36020.000811.382244.6684AID686978; AID686979
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency25.07470.001530.607315,848.9004AID1224819; AID1224820; AID1224821
67.9K proteinVaccinia virusPotency20.38650.00018.4406100.0000AID720579; AID720580
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency0.02240.035520.977089.1251AID504332
Bloom syndrome protein isoform 1Homo sapiens (human)Potency0.00110.540617.639296.1227AID2364; AID2528
hemoglobin subunit betaHomo sapiens (human)Potency1.25890.31629.086131.6228AID910
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency14.97630.316212.443531.6228AID902; AID924
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency5.12090.00798.23321,122.0200AID2546; AID2551
survival motor neuron protein isoform dHomo sapiens (human)Potency31.62280.125912.234435.4813AID1458
lamin isoform A-delta10Homo sapiens (human)Potency9.47010.891312.067628.1838AID1459; AID1487
Integrin beta-3Homo sapiens (human)Potency19.95260.316211.415731.6228AID924
Integrin alpha-IIbHomo sapiens (human)Potency19.95260.316211.415731.6228AID924
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, ADENOSINE DEAMINASEMus musculus (house mouse)Ki9.00009.00009.00009.0000AID977610
Adenosine deaminaseHomo sapiens (human)Ki7.00000.00000.30887.0000AID554264
Cytidine deaminaseMus musculus (house mouse)Ki10.00002.00006.000010.0000AID55384
Adenosine deaminase Bos taurus (cattle)Ki11.00000.00000.48937.0000AID33657; AID554263
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (127)

Processvia Protein(s)Taxonomy
adenosine catabolic processAdenosine deaminaseHomo sapiens (human)
inosine biosynthetic processAdenosine deaminaseHomo sapiens (human)
allantoin metabolic processAdenosine deaminaseHomo sapiens (human)
response to hypoxiaAdenosine deaminaseHomo sapiens (human)
trophectodermal cell differentiationAdenosine deaminaseHomo sapiens (human)
liver developmentAdenosine deaminaseHomo sapiens (human)
placenta developmentAdenosine deaminaseHomo sapiens (human)
germinal center B cell differentiationAdenosine deaminaseHomo sapiens (human)
germinal center formationAdenosine deaminaseHomo sapiens (human)
positive regulation of germinal center formationAdenosine deaminaseHomo sapiens (human)
negative regulation of leukocyte migrationAdenosine deaminaseHomo sapiens (human)
mature B cell apoptotic processAdenosine deaminaseHomo sapiens (human)
negative regulation of mature B cell apoptotic processAdenosine deaminaseHomo sapiens (human)
adenosine catabolic processAdenosine deaminaseHomo sapiens (human)
deoxyadenosine catabolic processAdenosine deaminaseHomo sapiens (human)
AMP catabolic processAdenosine deaminaseHomo sapiens (human)
xenobiotic metabolic processAdenosine deaminaseHomo sapiens (human)
smooth muscle contractionAdenosine deaminaseHomo sapiens (human)
cell adhesionAdenosine deaminaseHomo sapiens (human)
response to inorganic substanceAdenosine deaminaseHomo sapiens (human)
positive regulation of heart rateAdenosine deaminaseHomo sapiens (human)
response to purine-containing compoundAdenosine deaminaseHomo sapiens (human)
calcium-mediated signalingAdenosine deaminaseHomo sapiens (human)
positive regulation of B cell proliferationAdenosine deaminaseHomo sapiens (human)
purine nucleotide salvageAdenosine deaminaseHomo sapiens (human)
GMP salvageAdenosine deaminaseHomo sapiens (human)
T cell differentiation in thymusAdenosine deaminaseHomo sapiens (human)
positive regulation of T cell differentiation in thymusAdenosine deaminaseHomo sapiens (human)
regulation of cell-cell adhesion mediated by integrinAdenosine deaminaseHomo sapiens (human)
B cell proliferationAdenosine deaminaseHomo sapiens (human)
T cell activationAdenosine deaminaseHomo sapiens (human)
penile erectionAdenosine deaminaseHomo sapiens (human)
purine-containing compound salvageAdenosine deaminaseHomo sapiens (human)
amide catabolic processAdenosine deaminaseHomo sapiens (human)
AMP salvageAdenosine deaminaseHomo sapiens (human)
positive regulation of smooth muscle contractionAdenosine deaminaseHomo sapiens (human)
dAMP catabolic processAdenosine deaminaseHomo sapiens (human)
dATP catabolic processAdenosine deaminaseHomo sapiens (human)
adenosine metabolic processAdenosine deaminaseHomo sapiens (human)
inosine biosynthetic processAdenosine deaminaseHomo sapiens (human)
xanthine biosynthetic processAdenosine deaminaseHomo sapiens (human)
alpha-beta T cell differentiationAdenosine deaminaseHomo sapiens (human)
positive regulation of alpha-beta T cell differentiationAdenosine deaminaseHomo sapiens (human)
lung alveolus developmentAdenosine deaminaseHomo sapiens (human)
Peyer's patch developmentAdenosine deaminaseHomo sapiens (human)
embryonic digestive tract developmentAdenosine deaminaseHomo sapiens (human)
negative regulation of inflammatory responseAdenosine deaminaseHomo sapiens (human)
positive regulation of calcium-mediated signalingAdenosine deaminaseHomo sapiens (human)
T cell receptor signaling pathwayAdenosine deaminaseHomo sapiens (human)
positive regulation of T cell receptor signaling pathwayAdenosine deaminaseHomo sapiens (human)
leukocyte migrationAdenosine deaminaseHomo sapiens (human)
negative regulation of adenosine receptor signaling pathwayAdenosine deaminaseHomo sapiens (human)
negative regulation of penile erectionAdenosine deaminaseHomo sapiens (human)
thymocyte apoptotic processAdenosine deaminaseHomo sapiens (human)
negative regulation of thymocyte apoptotic processAdenosine deaminaseHomo sapiens (human)
mucus secretionAdenosine deaminaseHomo sapiens (human)
negative regulation of mucus secretionAdenosine deaminaseHomo sapiens (human)
hypoxanthine salvageAdenosine deaminaseHomo sapiens (human)
negative regulation of low-density lipoprotein receptor activityIntegrin beta-3Homo sapiens (human)
positive regulation of protein phosphorylationIntegrin beta-3Homo sapiens (human)
positive regulation of endothelial cell proliferationIntegrin beta-3Homo sapiens (human)
positive regulation of cell-matrix adhesionIntegrin beta-3Homo sapiens (human)
cell-substrate junction assemblyIntegrin beta-3Homo sapiens (human)
cell adhesionIntegrin beta-3Homo sapiens (human)
cell-matrix adhesionIntegrin beta-3Homo sapiens (human)
integrin-mediated signaling pathwayIntegrin beta-3Homo sapiens (human)
embryo implantationIntegrin beta-3Homo sapiens (human)
blood coagulationIntegrin beta-3Homo sapiens (human)
positive regulation of endothelial cell migrationIntegrin beta-3Homo sapiens (human)
positive regulation of gene expressionIntegrin beta-3Homo sapiens (human)
negative regulation of macrophage derived foam cell differentiationIntegrin beta-3Homo sapiens (human)
positive regulation of fibroblast migrationIntegrin beta-3Homo sapiens (human)
negative regulation of lipid storageIntegrin beta-3Homo sapiens (human)
response to activityIntegrin beta-3Homo sapiens (human)
smooth muscle cell migrationIntegrin beta-3Homo sapiens (human)
positive regulation of smooth muscle cell migrationIntegrin beta-3Homo sapiens (human)
platelet activationIntegrin beta-3Homo sapiens (human)
positive regulation of vascular endothelial growth factor receptor signaling pathwayIntegrin beta-3Homo sapiens (human)
cell-substrate adhesionIntegrin beta-3Homo sapiens (human)
activation of protein kinase activityIntegrin beta-3Homo sapiens (human)
negative regulation of lipid transportIntegrin beta-3Homo sapiens (human)
regulation of protein localizationIntegrin beta-3Homo sapiens (human)
regulation of actin cytoskeleton organizationIntegrin beta-3Homo sapiens (human)
cell adhesion mediated by integrinIntegrin beta-3Homo sapiens (human)
positive regulation of cell adhesion mediated by integrinIntegrin beta-3Homo sapiens (human)
positive regulation of osteoblast proliferationIntegrin beta-3Homo sapiens (human)
heterotypic cell-cell adhesionIntegrin beta-3Homo sapiens (human)
substrate adhesion-dependent cell spreadingIntegrin beta-3Homo sapiens (human)
tube developmentIntegrin beta-3Homo sapiens (human)
wound healing, spreading of epidermal cellsIntegrin beta-3Homo sapiens (human)
cellular response to platelet-derived growth factor stimulusIntegrin beta-3Homo sapiens (human)
apolipoprotein A-I-mediated signaling pathwayIntegrin beta-3Homo sapiens (human)
wound healingIntegrin beta-3Homo sapiens (human)
apoptotic cell clearanceIntegrin beta-3Homo sapiens (human)
regulation of bone resorptionIntegrin beta-3Homo sapiens (human)
positive regulation of angiogenesisIntegrin beta-3Homo sapiens (human)
positive regulation of bone resorptionIntegrin beta-3Homo sapiens (human)
symbiont entry into host cellIntegrin beta-3Homo sapiens (human)
platelet-derived growth factor receptor signaling pathwayIntegrin beta-3Homo sapiens (human)
positive regulation of fibroblast proliferationIntegrin beta-3Homo sapiens (human)
mesodermal cell differentiationIntegrin beta-3Homo sapiens (human)
positive regulation of smooth muscle cell proliferationIntegrin beta-3Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylationIntegrin beta-3Homo sapiens (human)
negative regulation of lipoprotein metabolic processIntegrin beta-3Homo sapiens (human)
negative chemotaxisIntegrin beta-3Homo sapiens (human)
regulation of release of sequestered calcium ion into cytosolIntegrin beta-3Homo sapiens (human)
regulation of serotonin uptakeIntegrin beta-3Homo sapiens (human)
angiogenesis involved in wound healingIntegrin beta-3Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascadeIntegrin beta-3Homo sapiens (human)
platelet aggregationIntegrin beta-3Homo sapiens (human)
cellular response to mechanical stimulusIntegrin beta-3Homo sapiens (human)
cellular response to xenobiotic stimulusIntegrin beta-3Homo sapiens (human)
positive regulation of glomerular mesangial cell proliferationIntegrin beta-3Homo sapiens (human)
blood coagulation, fibrin clot formationIntegrin beta-3Homo sapiens (human)
maintenance of postsynaptic specialization structureIntegrin beta-3Homo sapiens (human)
regulation of postsynaptic neurotransmitter receptor internalizationIntegrin beta-3Homo sapiens (human)
regulation of postsynaptic neurotransmitter receptor diffusion trappingIntegrin beta-3Homo sapiens (human)
positive regulation of substrate adhesion-dependent cell spreadingIntegrin beta-3Homo sapiens (human)
positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathwayIntegrin beta-3Homo sapiens (human)
regulation of trophoblast cell migrationIntegrin beta-3Homo sapiens (human)
regulation of extracellular matrix organizationIntegrin beta-3Homo sapiens (human)
cellular response to insulin-like growth factor stimulusIntegrin beta-3Homo sapiens (human)
negative regulation of endothelial cell apoptotic processIntegrin beta-3Homo sapiens (human)
positive regulation of T cell migrationIntegrin beta-3Homo sapiens (human)
cell migrationIntegrin beta-3Homo sapiens (human)
positive regulation of leukocyte migrationIntegrin alpha-IIbHomo sapiens (human)
cell-matrix adhesionIntegrin alpha-IIbHomo sapiens (human)
integrin-mediated signaling pathwayIntegrin alpha-IIbHomo sapiens (human)
angiogenesisIntegrin alpha-IIbHomo sapiens (human)
cell-cell adhesionIntegrin alpha-IIbHomo sapiens (human)
cell adhesion mediated by integrinIntegrin alpha-IIbHomo sapiens (human)
adenosine catabolic processAdenosine deaminase Bos taurus (cattle)
cell adhesionAdenosine deaminase Bos taurus (cattle)
nucleotide metabolic processAdenosine deaminase Bos taurus (cattle)
purine ribonucleoside monophosphate biosynthetic processAdenosine deaminase Bos taurus (cattle)
inosine biosynthetic processAdenosine deaminase Bos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (25)

Processvia Protein(s)Taxonomy
adenosine deaminase activityAdenosine deaminaseHomo sapiens (human)
protein bindingAdenosine deaminaseHomo sapiens (human)
zinc ion bindingAdenosine deaminaseHomo sapiens (human)
deaminase activityAdenosine deaminaseHomo sapiens (human)
2'-deoxyadenosine deaminase activityAdenosine deaminaseHomo sapiens (human)
fibroblast growth factor bindingIntegrin beta-3Homo sapiens (human)
C-X3-C chemokine bindingIntegrin beta-3Homo sapiens (human)
insulin-like growth factor I bindingIntegrin beta-3Homo sapiens (human)
neuregulin bindingIntegrin beta-3Homo sapiens (human)
virus receptor activityIntegrin beta-3Homo sapiens (human)
fibronectin bindingIntegrin beta-3Homo sapiens (human)
protease bindingIntegrin beta-3Homo sapiens (human)
protein disulfide isomerase activityIntegrin beta-3Homo sapiens (human)
protein kinase C bindingIntegrin beta-3Homo sapiens (human)
platelet-derived growth factor receptor bindingIntegrin beta-3Homo sapiens (human)
integrin bindingIntegrin beta-3Homo sapiens (human)
protein bindingIntegrin beta-3Homo sapiens (human)
coreceptor activityIntegrin beta-3Homo sapiens (human)
enzyme bindingIntegrin beta-3Homo sapiens (human)
identical protein bindingIntegrin beta-3Homo sapiens (human)
vascular endothelial growth factor receptor 2 bindingIntegrin beta-3Homo sapiens (human)
metal ion bindingIntegrin beta-3Homo sapiens (human)
cell adhesion molecule bindingIntegrin beta-3Homo sapiens (human)
extracellular matrix bindingIntegrin beta-3Homo sapiens (human)
fibrinogen bindingIntegrin beta-3Homo sapiens (human)
protein bindingIntegrin alpha-IIbHomo sapiens (human)
identical protein bindingIntegrin alpha-IIbHomo sapiens (human)
metal ion bindingIntegrin alpha-IIbHomo sapiens (human)
extracellular matrix bindingIntegrin alpha-IIbHomo sapiens (human)
molecular adaptor activityIntegrin alpha-IIbHomo sapiens (human)
fibrinogen bindingIntegrin alpha-IIbHomo sapiens (human)
integrin bindingIntegrin alpha-IIbHomo sapiens (human)
adenosine deaminase activityAdenosine deaminase Bos taurus (cattle)
protein bindingAdenosine deaminase Bos taurus (cattle)
zinc ion bindingAdenosine deaminase Bos taurus (cattle)
2'-deoxyadenosine deaminase activityAdenosine deaminase Bos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (35)

Processvia Protein(s)Taxonomy
lysosomeAdenosine deaminaseHomo sapiens (human)
cytosolAdenosine deaminaseHomo sapiens (human)
plasma membraneAdenosine deaminaseHomo sapiens (human)
external side of plasma membraneAdenosine deaminaseHomo sapiens (human)
cell surfaceAdenosine deaminaseHomo sapiens (human)
membraneAdenosine deaminaseHomo sapiens (human)
cytoplasmic vesicle lumenAdenosine deaminaseHomo sapiens (human)
anchoring junctionAdenosine deaminaseHomo sapiens (human)
cytosolAdenosine deaminaseHomo sapiens (human)
external side of plasma membraneAdenosine deaminaseHomo sapiens (human)
glutamatergic synapseIntegrin beta-3Homo sapiens (human)
nucleusIntegrin beta-3Homo sapiens (human)
nucleoplasmIntegrin beta-3Homo sapiens (human)
plasma membraneIntegrin beta-3Homo sapiens (human)
cell-cell junctionIntegrin beta-3Homo sapiens (human)
focal adhesionIntegrin beta-3Homo sapiens (human)
external side of plasma membraneIntegrin beta-3Homo sapiens (human)
cell surfaceIntegrin beta-3Homo sapiens (human)
apical plasma membraneIntegrin beta-3Homo sapiens (human)
platelet alpha granule membraneIntegrin beta-3Homo sapiens (human)
lamellipodium membraneIntegrin beta-3Homo sapiens (human)
filopodium membraneIntegrin beta-3Homo sapiens (human)
microvillus membraneIntegrin beta-3Homo sapiens (human)
ruffle membraneIntegrin beta-3Homo sapiens (human)
integrin alphav-beta3 complexIntegrin beta-3Homo sapiens (human)
melanosomeIntegrin beta-3Homo sapiens (human)
synapseIntegrin beta-3Homo sapiens (human)
postsynaptic membraneIntegrin beta-3Homo sapiens (human)
extracellular exosomeIntegrin beta-3Homo sapiens (human)
integrin alphaIIb-beta3 complexIntegrin beta-3Homo sapiens (human)
glycinergic synapseIntegrin beta-3Homo sapiens (human)
integrin complexIntegrin beta-3Homo sapiens (human)
protein-containing complexIntegrin beta-3Homo sapiens (human)
alphav-beta3 integrin-PKCalpha complexIntegrin beta-3Homo sapiens (human)
alphav-beta3 integrin-IGF-1-IGF1R complexIntegrin beta-3Homo sapiens (human)
alphav-beta3 integrin-HMGB1 complexIntegrin beta-3Homo sapiens (human)
receptor complexIntegrin beta-3Homo sapiens (human)
alphav-beta3 integrin-vitronectin complexIntegrin beta-3Homo sapiens (human)
alpha9-beta1 integrin-ADAM8 complexIntegrin beta-3Homo sapiens (human)
focal adhesionIntegrin beta-3Homo sapiens (human)
cell surfaceIntegrin beta-3Homo sapiens (human)
synapseIntegrin beta-3Homo sapiens (human)
plasma membraneIntegrin alpha-IIbHomo sapiens (human)
focal adhesionIntegrin alpha-IIbHomo sapiens (human)
cell surfaceIntegrin alpha-IIbHomo sapiens (human)
platelet alpha granule membraneIntegrin alpha-IIbHomo sapiens (human)
extracellular exosomeIntegrin alpha-IIbHomo sapiens (human)
integrin alphaIIb-beta3 complexIntegrin alpha-IIbHomo sapiens (human)
blood microparticleIntegrin alpha-IIbHomo sapiens (human)
integrin complexIntegrin alpha-IIbHomo sapiens (human)
external side of plasma membraneIntegrin alpha-IIbHomo sapiens (human)
lysosomeAdenosine deaminase Bos taurus (cattle)
cytoplasmic vesicle lumenAdenosine deaminase Bos taurus (cattle)
anchoring junctionAdenosine deaminase Bos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (36)

Assay IDTitleYearJournalArticle
AID1347057CD47-SIRPalpha protein protein interaction - LANCE assay qHTS validation2019PloS one, , Volume: 14, Issue:7
Quantitative high-throughput screening assays for the discovery and development of SIRPĪ±-CD47 interaction inhibitors.
AID1347410qHTS for inhibitors of adenylyl cyclases using a fission yeast platform: a pilot screen against the NCATS LOPAC library2019Cellular signalling, 08, Volume: 60A fission yeast platform for heterologous expression of mammalian adenylyl cyclases and high throughput screening.
AID1347049Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot screen2019Science translational medicine, 07-10, Volume: 11, Issue:500
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
AID588349qHTS for Inhibitors of ATXN expression: Validation of Cytotoxic Assay
AID588378qHTS for Inhibitors of ATXN expression: Validation
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1347045Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot counterscreen GloSensor control cell line2019Science translational medicine, 07-10, Volume: 11, Issue:500
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
AID1347405qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS LOPAC collection2020ACS chemical biology, 07-17, Volume: 15, Issue:7
High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1347059CD47-SIRPalpha protein protein interaction - Alpha assay qHTS validation2019PloS one, , Volume: 14, Issue:7
Quantitative high-throughput screening assays for the discovery and development of SIRPĪ±-CD47 interaction inhibitors.
AID1347086qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347058CD47-SIRPalpha protein protein interaction - HTRF assay qHTS validation2019PloS one, , Volume: 14, Issue:7
Quantitative high-throughput screening assays for the discovery and development of SIRPĪ±-CD47 interaction inhibitors.
AID1508630Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay2021Cell reports, 04-27, Volume: 35, Issue:4
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1347151Optimization of GU AMC qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347082qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID504836Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in human glioma: Validation2002The Journal of biological chemistry, Apr-19, Volume: 277, Issue:16
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
AID1347083qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347050Natriuretic polypeptide receptor (hNpr2) antagonism - Pilot subtype selectivity assay2019Science translational medicine, 07-10, Volume: 11, Issue:500
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
AID116794Percent increase in life span of drug-treated mice relative to tumored, vehicle treated controls at a dose of 6.25 mg/kg ip.1991Journal of medicinal chemistry, Nov, Volume: 34, Issue:11
Antitumor properties of 2(1H)-pyrimidinone riboside (zebularine) and its fluorinated analogues.
AID228918Molar potency ratio was evaluated1985Journal of medicinal chemistry, Nov, Volume: 28, Issue:11
Dog coronary artery adenosine receptor: structure of the N6-alkyl subregion.
AID124815Antitumor activity against P388 tumor in mice, at a dose of 6.25 mg/kg per ip administration.1991Journal of medicinal chemistry, Nov, Volume: 34, Issue:11
Antitumor properties of 2(1H)-pyrimidinone riboside (zebularine) and its fluorinated analogues.
AID33657Binding affinity against calf intestine adenosine deaminase enzyme1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Adenosine deaminase inhibitors. Synthesis of deaza analogues of erythro-9-(2-hydroxy-3-nonyl)adenine.
AID1065714Trypanocidal activity against bloodstream stage of Trypanosoma brucei brucei AnTat1.1E after 72 hrs by WST-1 assay2013Journal of medicinal chemistry, Dec-27, Volume: 56, Issue:24
Structure-activity relationships of synthetic cordycepin analogues as experimental therapeutics for African trypanosomiasis.
AID116788Percent increase in life span of drug-treated mice relative to tumored, vehicle treated controls at a dose of 3.13 mg/kg ip.1991Journal of medicinal chemistry, Nov, Volume: 34, Issue:11
Antitumor properties of 2(1H)-pyrimidinone riboside (zebularine) and its fluorinated analogues.
AID124812Antitumor activity against P388 tumor in mice, at a dose of 3.13 mg/kg per ip administration.1991Journal of medicinal chemistry, Nov, Volume: 34, Issue:11
Antitumor properties of 2(1H)-pyrimidinone riboside (zebularine) and its fluorinated analogues.
AID1065706Cytotoxicity against mouse L929 cells assessed as cell viability after 72 hrs by WST-1 assay2013Journal of medicinal chemistry, Dec-27, Volume: 56, Issue:24
Structure-activity relationships of synthetic cordycepin analogues as experimental therapeutics for African trypanosomiasis.
AID216185Anti-Herpes simplex virus type-1 activity in vero cells using plaque inhibition assay1999Journal of medicinal chemistry, Aug-26, Volume: 42, Issue:17
Virtual combinatorial syntheses and computational screening of new potential anti-herpes compounds.
AID584550Cytotoxicity against mouse J774A1 cells2010Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12
Testing nucleoside analogues as inhibitors of Bacillus anthracis spore germination in vitro and in macrophage cell culture.
AID584547Antibacterial activity against Bacillus anthracis Sterne 34F2 infected in mouse J774A.1 cells assessed as protection against bacteria-induced cytotoxicity using propidium iodide staining after 3 hrs measured every hours for up to 7 hrs2010Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12
Testing nucleoside analogues as inhibitors of Bacillus anthracis spore germination in vitro and in macrophage cell culture.
AID554263Inhibition of calf intestine adenosine deaminase by Lineweaver-Burk plot analysis2011Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1
Investigations into the origin of the molecular recognition of several adenosine deaminase inhibitors.
AID554264Inhibition of adenosine deaminase2011Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1
Investigations into the origin of the molecular recognition of several adenosine deaminase inhibitors.
AID584546Inhibition of inosine/L-alanine-induced Bacillus anthracis Sterne 34F2 spore germination pretreated for 15 mins before inosine/L-alanine challenge2010Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12
Testing nucleoside analogues as inhibitors of Bacillus anthracis spore germination in vitro and in macrophage cell culture.
AID55384Compound was tested for the inhibitory constant for mouse kidney cytidine deaminase1986Journal of medicinal chemistry, Aug, Volume: 29, Issue:8
Synthesis of pyrimidin-2-one nucleosides as acid-stable inhibitors of cytidine deaminase.
AID1159607Screen for inhibitors of RMI FANCM (MM2) intereaction2016Journal of biomolecular screening, Jul, Volume: 21, Issue:6
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
AID977610Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB1996Biochemistry, Jun-18, Volume: 35, Issue:24
Probing the functional role of two conserved active site aspartates in mouse adenosine deaminase.
AID1811Experimentally measured binding affinity data derived from PDB1996Biochemistry, Jun-18, Volume: 35, Issue:24
Probing the functional role of two conserved active site aspartates in mouse adenosine deaminase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (82)

TimeframeStudies, This Drug (%)All Drugs %
pre-199030 (36.59)18.7374
1990's22 (26.83)18.2507
2000's10 (12.20)29.6817
2010's13 (15.85)24.3611
2020's7 (8.54)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (1.19%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other83 (98.81%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
cytarabine[no description available]medium10beta-D-arabinoside;
monosaccharide derivative;
pyrimidine nucleoside		antimetabolite;
antineoplastic agent;
antiviral agent;
immunosuppressive agent
pyrimidin-2-one beta-ribofuranoside[no description available]medium20pyrimidine ribonucleosides
6-hydroxyadenosine[no description available]medium10
adenosine[no description available]medium110adenosines;
purines D-ribonucleoside		analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent
6-chloropurine riboside[no description available]medium20
phenylisopropyladenosine[no description available]medium10aromatic amine;
benzenes;
hydrocarbyladenosine;
purine nucleoside;
secondary amino compound		adenosine A1 receptor agonist;
neuroprotective agent
n-allyladenosine[no description available]medium10purine nucleoside
6-methylpurine riboside[no description available]medium10
n-methyladenosine[no description available]medium20methyladenosine
6-methoxypurine arabinoside[no description available]medium10
n(6),n(6)-dimethyladenosine[no description available]medium30hydrocarbyladenosine
n(6)-cyclopentyladenosine[no description available]medium10
n-(1-methyl-2-phenylethyl)adenosine, (s)-isomer[no description available]medium10
1-aminoadenosine[no description available]medium10
n(6)-cyclohexyladenosine[no description available]medium10
3-deazaadenosine[no description available]medium20
coformycin[no description available]medium20coformycinsEC 3.5.4.4 (adenosine deaminase) inhibitor
9-(2-hydroxy-3-nonyl)adenine[no description available]medium10EHNAEC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
EC 3.5.4.4 (adenosine deaminase) inhibitor
1-deazaadenosine[no description available]medium30
pentostatin[no description available]medium20coformycinsantimetabolite;
antineoplastic agent;
Aspergillus metabolite;
bacterial metabolite;
EC 3.5.4.4 (adenosine deaminase) inhibitor
adipic acid[no description available]medium10alpha,omega-dicarboxylic acid;
dicarboxylic fatty acid		food acidity regulator;
human xenobiotic metabolite
succinic acid[no description available]medium10alpha,omega-dicarboxylic acid;
C4-dicarboxylic acid		anti-ulcer drug;
fundamental metabolite;
micronutrient;
nutraceutical;
radiation protective agent
thymidine[no description available]medium10pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite
cordycepin[no description available]medium203'-deoxyribonucleoside;
adenosines		antimetabolite;
nucleoside antibiotic
formaldoxime[no description available]medium10
tropine[no description available]medium10
5-nitrobarbituric acid[no description available]medium10
deoxyuridine[no description available]medium20pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
5-nitrouracil[no description available]medium10C-nitro compound
5-methylcytidine[no description available]medium10methylcytidine
4,4'-azobis(phenol)[no description available]medium10
7-hydroxycoumarin[no description available]medium10hydroxycoumarinfluorescent probe;
food component;
plant metabolite
nitrofurantoin[no description available]medium10imidazolidine-2,4-dione;
nitrofuran antibiotic;
organonitrogen heterocyclic antibiotic;
organooxygen heterocyclic antibiotic		antibacterial drug;
antiinfective agent;
hepatotoxic agent
inosine[no description available]medium90inosines;
purines D-ribonucleoside		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
tubercidin[no description available]medium90antibiotic antifungal agent;
N-glycosylpyrrolopyrimidine;
ribonucleoside		antimetabolite;
antineoplastic agent;
bacterial metabolite
methylthioinosine[no description available]medium10purine ribonucleoside;
thiopurine
isopentenyladenosine[no description available]medium10N-ribosyl-N(6)-isopentenyladenine;
nucleoside analogue		antineoplastic agent;
plant growth regulator;
plant metabolite
benzylaminopurine[no description available]medium106-aminopurinescytokinin;
plant metabolite
xanthosine[no description available]medium10purines D-ribonucleoside;
xanthosines		Escherichia coli metabolite;
human metabolite;
mouse metabolite
isoguanosine[no description available]medium10purine nucleoside
D-alanine[no description available]medium10alanine zwitterion;
alanine;
D-alpha-amino acid		EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
Escherichia coli metabolite;
human metabolite
2-aminoadenosine[no description available]medium10purine nucleoside
6'-o-methylguanosine[no description available]medium10
8-aminoadenosine[no description available]medium20
mercaptopurine[no description available]medium10aryl thiol;
purines;
thiocarbonyl compound		anticoronaviral agent;
antimetabolite;
antineoplastic agent
thioinosine[no description available]medium40
2-mercaptobenzimidazole[no description available]medium10
thiouracil[no description available]medium10nucleobase analogue;
thiocarbonyl compound		antithyroid drug;
metabolite
pyrimidine-2-thiol[no description available]medium10aryl thiol;
pyrimidines		allergen;
corrosion inhibitor
thioguanine anhydrous[no description available]medium102-aminopurinesanticoronaviral agent;
antimetabolite;
antineoplastic agent
2-thiopyridine[no description available]medium10aryl thiol;
pyridines		allergen;
fluorescence quencher
4-thiopyridine[no description available]medium10
6-thioguanosine[no description available]medium10purine nucleoside
2-amino-6-chloropurine[no description available]medium102-aminopurines;
organochlorine compound
6-benzylthioinosine[no description available]medium10
guanosine[no description available]medium20guanosines;
purines D-ribonucleoside		fundamental metabolite
ganciclovir[no description available]medium102-aminopurines;
oxopurine		antiinfective agent;
antiviral drug
allopurinol[no description available]medium10nucleobase analogue;
organic heterobicyclic compound		antimetabolite;
EC 1.17.3.2 (xanthine oxidase) inhibitor;
gout suppressant;
radical scavenger
8-hydroxyguanosine[no description available]medium10purine nucleoside
7-deazainosine[no description available]medium20
7-methylinosine[no description available]medium10inosines;
organic cation		metabolite
2-chloroadenosine[no description available]medium30purine nucleoside
8-azanebularine[no description available]medium10
adenine[no description available]medium206-aminopurines;
purine nucleobase		Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
2-fluoroadenosine[no description available]medium10adenosines;
organofluorine compound
2-fluoroadenine[no description available]medium10organofluorine compound;
purines		antineoplastic agent
vidarabine[no description available]medium20beta-D-arabinoside;
purine nucleoside		antineoplastic agent;
bacterial metabolite;
nucleoside antibiotic
adenosine 2',3'-ribo-epoxide[no description available]medium10
2-chloroadenine[no description available]medium10
2-chloro-3'-deoxyadenosine[no description available]medium10
phosphoramidite[no description available]medium10
2-aminopurine[no description available]medium202-aminopurines;
nucleobase analogue		antimetabolite
guanine[no description available]medium202-aminopurines;
oxopurine;
purine nucleobase		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
cytosine[no description available]medium10aminopyrimidine;
pyrimidine nucleobase;
pyrimidone		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
nsc 520594[no description available]medium10
pyrazole[no description available]medium10pyrazole
glycosides[no description available]medium10
warfarin[no description available]medium10benzenes;
hydroxycoumarin;
methyl ketone
furan[no description available]medium10furans;
mancude organic heteromonocyclic parent;
monocyclic heteroarene		carcinogenic agent;
hepatotoxic agent;
Maillard reaction product
hydroxide ion[no description available]medium10oxygen hydridemouse metabolite
coumarin[no description available]medium10coumarinsfluorescent dye;
human metabolite;
plant metabolite
palladium[no description available]medium10metal allergen;
nickel group element atom;
platinum group metal atom
deoxyguanosine[no description available]medium10purine 2'-deoxyribonucleoside;
purines 2'-deoxy-D-ribonucleoside		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
gibberellins[no description available]medium10
gibberellic acid[no description available]medium10C19-gibberellin;
gibberellin monocarboxylic acid;
lactone;
organic heteropentacyclic compound		mouse metabolite;
plant metabolite
uniconazole[no description available]medium10monochlorobenzenes;
secondary alcohol;
triazoles
triazoles[no description available]medium101,2,3-triazole
purine[no description available]medium20purine
pyrimidine[no description available]medium10diazine;
pyrimidines		Daphnia magna metabolite
uric acid[no description available]medium10uric acidEscherichia coli metabolite;
human metabolite;
mouse metabolite
6-hydroxyl-1,6-dihydropurine ribonucleoside[no description available]medium10
fluorides[no description available]medium10halide anion;
monoatomic fluorine
deuterium[no description available]medium10dihydrogen
nitrobenzylthioinosine 5'-monophosphate[no description available]medium20
nad[no description available]medium10organophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite
acetonitrile[no description available]medium10aliphatic nitrile;
volatile organic compound		EC 3.5.1.4 (amidase) inhibitor;
NMR chemical shift reference compound;
polar aprotic solvent
1,4-dioxane[no description available]medium10dioxane;
volatile organic compound		carcinogenic agent;
metabolite;
NMR chemical shift reference compound;
non-polar solvent
methanol[no description available]medium10alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound		amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite
sucrose[no description available]medium10glycosyl glycosidealgal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent
glutamic acid[no description available]medium10glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical
6-methylpurine[no description available]medium10purinesEC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor
thiazoles[no description available]medium101,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
formycins[no description available]medium20
aristeromycin[no description available]medium10
difluorotoluene[no description available]medium10
toluene[no description available]medium10methylbenzene;
toluenes;
volatile organic compound		cholinergic antagonist;
fuel additive;
neurotoxin;
non-polar solvent
thymine[no description available]medium10pyrimidine nucleobase;
pyrimidone		Escherichia coli metabolite;
human metabolite;
mouse metabolite
8-hydroxyguanine[no description available]medium10oxopurine
5-iodotubercidin[no description available]medium10organoiodine compound
adenosine kinase[no description available]medium10
alanine[no description available]medium10alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid		EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite
4-nitrobenzylthioinosine[no description available]medium10purine nucleoside
hypoxanthine[no description available]medium10nucleobase analogue;
oxopurine;
purine nucleobase		fundamental metabolite
2'-deoxyadenosine[no description available]medium10purine 2'-deoxyribonucleoside;
purines 2'-deoxy-D-ribonucleoside		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
3-deazaaristeromycin[no description available]medium10
3'-deoxyinosine[no description available]medium10
formycin b[no description available]medium10formycin
sepharose[no description available]medium10
2-deoxyribose 1-phosphate, (alpha-d-erythro)-isomer[no description available]medium102-deoxy-D-ribofuranose 1-phosphate
hydroxyl radical[no description available]medium10oxygen hydride;
oxygen radical;
reactive oxygen species
9-deazaadenosine[no description available]medium10
dipyridamole[no description available]medium10piperidines;
pyrimidopyrimidine;
tertiary amino compound;
tetrol		adenosine phosphodiesterase inhibitor;
EC 3.5.4.4 (adenosine deaminase) inhibitor;
platelet aggregation inhibitor;
vasodilator agent
toyocamycin[no description available]medium10antibiotic antifungal agent;
N-glycosylpyrrolopyrimidine;
nitrile;
ribonucleoside		antimetabolite;
antineoplastic agent;
apoptosis inducer;
bacterial metabolite
5-benzylacyclouridine[no description available]medium10hydroxyether;
primary alcohol;
pyrimidone
uracil[no description available]medium10pyrimidine nucleobase;
pyrimidone		allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prodrug;
Saccharomyces cerevisiae metabolite
dilazep[no description available]medium20benzoate ester;
diazepane;
diester;
methoxybenzenes		cardioprotective agent;
platelet aggregation inhibitor;
vasodilator agent
4-hydroxyphenylacetic acid[no description available]low00monocarboxylic acid;
phenols		fungal metabolite;
human metabolite;
mouse metabolite;
plant metabolite
indoleacetamide[no description available]low00indoles;
monocarboxylic acid amide;
N-acylammonia		bacterial metabolite;
fungal metabolite;
plant metabolite
gamma-guanidinobutyric acid[no description available]low00guanidines;
monocarboxylic acid;
zwitterion		fungal metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
itaconic acid[no description available]low00dicarboxylic acid;
dicarboxylic fatty acid;
olefinic compound		fungal metabolite;
human metabolite
theophylline[no description available]low00dimethylxanthineadenosine receptor antagonist;
anti-asthmatic drug;
anti-inflammatory agent;
bronchodilator agent;
drug metabolite;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
fungal metabolite;
human blood serum metabolite;
immunomodulator;
muscle relaxant;
vasodilator agent
caffeine[no description available]low00purine alkaloid;
trimethylxanthine		adenosine A2A receptor antagonist;
adenosine receptor antagonist;
adjuvant;
central nervous system stimulant;
diuretic;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
environmental contaminant;
food additive;
fungal metabolite;
geroprotector;
human blood serum metabolite;
mouse metabolite;
mutagen;
plant metabolite;
psychotropic drug;
ryanodine receptor agonist;
xenobiotic
2,5-dihydroxybenzoic acid[no description available]low00dihydroxybenzoic acidEC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
fungal metabolite;
human metabolite;
MALDI matrix material;
mouse metabolite
muscimol[no description available]low00alkaloid;
isoxazoles;
primary amino compound		fungal metabolite;
GABA agonist;
oneirogen;
psychotropic drug
psilocin[no description available]low00hydroxyindoles;
phenols;
tertiary amino compound;
tryptamine alkaloid		drug metabolite;
fungal metabolite;
hallucinogen;
human xenobiotic metabolite;
serotonergic agonist
urethane[no description available]low00carbamate esterfungal metabolite;
mutagen
methyl n-methylanthranilate[no description available]low00benzoate ester;
methyl ester;
secondary amino compound;
substituted aniline		animal metabolite;
fungal metabolite;
plant metabolite
veratryl alcohol[no description available]low00benzyl alcohols;
dimethoxybenzene;
primary alcohol		fungal metabolite
4-hydroxyacetophenone[no description available]low00monohydroxyacetophenonefungal metabolite;
mouse metabolite;
plant metabolite
acrylonitrile[no description available]low00aliphatic nitrile;
volatile organic compound		antifungal agent;
carcinogenic agent;
fungal metabolite;
mutagen;
polar aprotic solvent
4-hydroxyphenylethanol[no description available]low00phenolsanti-arrhythmia drug;
antioxidant;
cardiovascular drug;
fungal metabolite;
geroprotector;
plant metabolite;
protective agent
psilocybin[no description available]low00organic phosphate;
tertiary amino compound;
tryptamine alkaloid		fungal metabolite;
hallucinogen;
prodrug;
serotonergic agonist
nonadecanoic acid[no description available]low00long-chain fatty acid;
straight-chain saturated fatty acid		fungal metabolite
3-methylfuran[no description available]low00furans;
volatile organic compound		Aspergillus metabolite;
environmental contaminant;
fungal metabolite;
Penicillium metabolite;
plant metabolite
gamma-dodecalactone[no description available]low00gamma-lactonebacterial metabolite;
fungal metabolite;
volatile oil component
1-octen-3-ol[no description available]low00alkenyl alcohol;
medium-chain fatty alcohol		antimicrobial agent;
fungal metabolite;
insect attractant;
volatile oil component
norsolorinic acid[no description available]low00polyketide;
tetrahydroxyanthraquinone		fungal metabolite
2-ethylhexanal[no description available]low00saturated fatty aldehydebacterial xenobiotic metabolite;
fungal metabolite
mevastatin[no description available]low002-pyranones;
carboxylic ester;
hexahydronaphthalenes;
polyketide;
statin (naturally occurring)		antifungal agent;
apoptosis inducer;
EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor;
fungal metabolite;
Penicillium metabolite
norharman[no description available]low00beta-carbolines;
mancude organic heterotricyclic parent		fungal metabolite;
marine metabolite
cephalosporin c[no description available]low00cephalosporinfungal metabolite
sulfur[no description available]low00elemental sulfur;
homomonocyclic compound		bacterial metabolite;
fungal metabolite
orsellinic acid[no description available]low00dihydroxybenzoic acid;
resorcinols		fungal metabolite;
marine metabolite;
metabolite
1,8-dihydroxynaphthalene[no description available]low00naphthalenediolfungal metabolite
siccanin[no description available]low00organic heteropentacyclic compoundantifungal drug;
fungal metabolite
rubrofusarin[no description available]low00aromatic ether;
benzochromenone;
phenols;
polyketide		biological pigment;
EC 1.14.18.1 (tyrosinase) inhibitor;
fungal metabolite
5-hydroxybenzofuran-2-one[no description available]low001-benzofurans;
aromatic alcohol		antifungal agent;
fungal metabolite
5-hydroxymethyl-2-furoic acid[no description available]low00aromatic primary alcohol;
furoic acid		bacterial xenobiotic metabolite;
fungal metabolite;
human urinary metabolite;
nematicide
fibrinogen[no description available]low00iditolfungal metabolite
3-hydroxybutyric acid[no description available]low003-hydroxybutyric acid;
ketone body		fungal metabolite;
human metabolite;
pheromone
orotidine[no description available]low00nucleoside;
pyrimidinemonocarboxylic acid;
uridines		bacterial metabolite;
fungal metabolite;
plant metabolite
atromentin[no description available]low00dihydroxy-1,4-benzoquinones;
polyphenol		antibacterial agent;
anticoagulant;
antineoplastic agent;
apoptosis inducer;
biological pigment;
EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor;
fungal metabolite
2'-o-methyladenosine[no description available]low00adenosines;
ether		fungal metabolite
ergosine[no description available]low00ergot alkaloidfungal metabolite
acromelic acid a[no description available]low00pyridone;
pyrrolidinecarboxylic acid;
tricarboxylic acid		fungal metabolite;
neurotoxin;
NMDA receptor agonist
trapoxin a[no description available]low00epoxide;
homodetic cyclic peptide;
ketone		antineoplastic agent;
EC 3.5.1.98 (histone deacetylase) inhibitor;
fungal metabolite
deoxyfuconojirimycin[no description available]low00hydroxypiperidine;
triol		fungal metabolite
emodin anthrone[no description available]low00anthracenone;
phenols		fungal metabolite
saintopin[no description available]low00tetracenequinonesantineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
fungal metabolite;
intercalator
cercosporamide[no description available]low00dibenzofurans;
methyl ketone;
monocarboxylic acid amide;
polyphenol		antifungal agent;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
fungal metabolite;
phytotoxin
baeocystin[no description available]low00organic phosphate;
secondary amino compound;
tryptamine alkaloid		fungal metabolite;
hallucinogen
albicanol[no description available]low00carbobicyclic compound;
homoallylic alcohol;
primary alcohol;
sesquiterpenoid		antifeedant;
antifungal agent;
antineoplastic agent;
fungal metabolite;
mammalian metabolite;
marine metabolite;
plant metabolite
ml 236a[no description available]low002-pyranones;
carbobicyclic compound;
hexahydronaphthalenes;
polyketide;
secondary alcohol		antiatherosclerotic agent;
anticholesteremic drug;
antilipemic drug;
antimicrobial agent;
EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor;
fungal metabolite
2,5-dihydroxybenzyl alcohol[no description available]low00aromatic primary alcohol;
phenols		antineoplastic agent;
antioxidant;
apoptosis inhibitor;
fungal metabolite
3-octanone[no description available]low00dialkyl ketoneantifeedant;
biomarker;
fungal metabolite;
human urinary metabolite;
insect attractant;
plant metabolite;
toxin
lenticin[no description available]low00amino-acid betaine;
indole alkaloid;
L-tryptophan derivative		fungal metabolite;
plant metabolite;
xenobiotic
ergonovine[no description available]low00ergot alkaloid;
monocarboxylic acid amide;
organic heterotetracyclic compound;
primary alcohol;
secondary amino compound;
tertiary amino compound		diagnostic agent;
fungal metabolite;
oxytocic;
toxin
ergosterol[no description available]low003beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
ergostanoid;
phytosterols		fungal metabolite;
Saccharomyces cerevisiae metabolite
eicosapentaenoic acid[no description available]low00icosapentaenoic acid;
omega-3 fatty acid		anticholesteremic drug;
antidepressant;
antineoplastic agent;
Daphnia galeata metabolite;
fungal metabolite;
micronutrient;
mouse metabolite;
nutraceutical
aphidicolin[no description available]low00tetracyclic diterpenoidantimicrobial agent;
antimitotic;
antineoplastic agent;
antiviral drug;
apoptosis inducer;
Aspergillus metabolite;
DNA synthesis inhibitor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
fungal metabolite
sordaricin[no description available]low003-oxo monocarboxylic acid;
aldehyde;
bridged compound;
primary alcohol;
tetracyclic diterpenoid		antifungal agent;
fungal metabolite
methyl cinnamate[no description available]low00methyl cinnamateantibacterial agent;
fungal metabolite;
nematicide;
plant metabolite
averufin[no description available]low00cyclic ketal;
organic heteropentacyclic compound;
polyketide;
polyphenol		fungal metabolite
rhodotorulic acid[no description available]low002,5-diketopiperazines;
hydroxamic acid;
L-ornithine derivative		fungal metabolite;
siderophore
helvolic acid[no description available]low003-oxo-Delta(1) steroid;
acetate ester;
monocarboxylic acid;
steroid acid		antibacterial agent;
fungal metabolite;
mycotoxin
beauvericin[no description available]low00cyclodepsipeptideantibiotic insecticide;
antifungal agent;
antineoplastic agent;
apoptosis inhibitor;
fungal metabolite;
ionophore;
mycotoxin;
P450 inhibitor
8,11,14-eicosatrienoic acid[no description available]low00fatty acid 20:3;
long-chain fatty acid		fungal metabolite;
human metabolite;
nutraceutical
canthaxanthin[no description available]low00carotenonebiological pigment;
Escherichia coli metabolite;
food colouring;
fungal metabolite
zearalenone[no description available]low00macrolide;
resorcinols		fungal metabolite;
mycoestrogen
norlichexanthone[no description available]low00polyphenol;
xanthones		antimalarial;
fungal metabolite
orobol[no description available]low007-hydroxyisoflavonesanti-inflammatory agent;
fungal metabolite;
plant metabolite;
radical scavenger
ellagic acid[no description available]low00catechols;
cyclic ketone;
lactone;
organic heterotetracyclic compound;
polyphenol		antioxidant;
EC 1.14.18.1 (tyrosinase) inhibitor;
EC 2.3.1.5 (arylamine N-acetyltransferase) inhibitor;
EC 2.4.1.1 (glycogen phosphorylase) inhibitor;
EC 2.5.1.18 (glutathione transferase) inhibitor;
EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor;
EC 2.7.1.151 (inositol-polyphosphate multikinase) inhibitor;
EC 2.7.4.6 (nucleoside-diphosphate kinase) inhibitor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
food additive;
fungal metabolite;
geroprotector;
plant metabolite;
skin lightening agent
t-2 toxin[no description available]low00acetate ester;
organic heterotetracyclic compound;
trichothecene		apoptosis inducer;
cardiotoxic agent;
DNA synthesis inhibitor;
environmental contaminant;
fungal metabolite;
mycotoxin;
neurotoxin
glycitein[no description available]low007-hydroxyisoflavone;
methoxyisoflavone		fungal metabolite;
phytoestrogen;
plant metabolite
ergothioneine[no description available]low001,3-dihydroimidazole-2-thiones;
amino-acid betaine;
L-histidine derivative;
sulfur-containing amino acid		antioxidant;
chelator;
fungal metabolite;
plant metabolite;
xenobiotic metabolite
alternariol monomethyl ether[no description available]low00aromatic ether;
benzochromenone		antifungal agent;
fungal metabolite;
mycotoxin
iditol[no description available]low00iditolfungal metabolite;
human metabolite
poricoic acid a[no description available]low00dicarboxylic acid;
secondary alcohol;
tricyclic triterpenoid		fungal metabolite
poricoic acid g[no description available]low00dicarboxylic acid;
secondary alcohol;
tricyclic triterpenoid		fungal metabolite
mevalonolactone[no description available]low004-hydroxy-4-methyloxan-2-onefungal metabolite;
plant metabolite
ascofuranone[no description available]low00dihydroxybenzaldehyde;
meroterpenoid;
monochlorobenzenes;
olefinic compound;
resorcinols;
sesquiterpenoid;
tetrahydrofuranone		angiogenesis inhibitor;
antilipemic drug;
antineoplastic agent;
antiprotozoal drug;
fungal metabolite
mucidin[no description available]low00enoate ester;
enol ether		antifungal agent;
fungal metabolite
squalestatin 1[no description available]low00acetate ester;
cyclic ketal;
oxabicycloalkane;
polyketide;
tertiary alcohol;
tricarboxylic acid		EC 2.5.1.21 (squalene synthase) inhibitor;
fungal metabolite
thermozymocidin[no description available]low00alpha-amino fatty acid;
hydroxy monocarboxylic acid;
non-proteinogenic alpha-amino acid;
sphingoid		antifungal agent;
antimicrobial agent;
antineoplastic agent;
apoptosis inducer;
EC 2.3.1.50 (serine C-palmitoyltransferase) inhibitor;
fungal metabolite;
immunosuppressive agent
acuminatin[no description available]low001-benzofurans;
dimethoxybenzene;
neolignan;
olefinic compound;
ring assembly		fungal metabolite;
plant metabolite
strobilurin b[no description available]low00enoate ester;
enol ether;
methoxyacrylate strobilurin antifungal agent;
monochlorobenzenes;
monomethoxybenzene		antifungal agent;
fungal metabolite;
mitochondrial cytochrome-bc1 complex inhibitor
ergosta-4,6,8(14),22-tetraen-3-one[no description available]low003-oxo-Delta(4) steroid;
ergostanoid		fungal metabolite
fumagillin[no description available]low00antibiotic antifungal drug;
carboxylic ester;
dicarboxylic acid monoester;
meroterpenoid;
organooxygen heterocyclic antibiotic;
spiro-epoxide		angiogenesis inhibitor;
antibacterial drug;
antimicrobial agent;
antiprotozoal drug;
fungal metabolite;
methionine aminopeptidase 2 inhibitor
altenusin[no description available]low00aromatic ether;
carboxybiphenyl;
catechols;
hydroxybiphenyls;
polyphenol		antifungal agent;
fungal metabolite
ebericol[no description available]low0014alpha-methyl steroid;
3beta-sterol;
tetracyclic triterpenoid		fungal metabolite
tmc-95a[no description available]low00indoles;
lactam;
macrocycle;
phenols;
secondary alcohol;
tertiary alcohol		antimicrobial agent;
antineoplastic agent;
bacterial metabolite;
fungal metabolite;
proteasome inhibitor
monacolin j[no description available]low002-pyranones;
carbobicyclic compound;
hexahydronaphthalenes;
polyketide;
secondary alcohol		antimicrobial agent;
EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor;
fungal metabolite
trachyspic acid[no description available]low00oxaspiro compound;
tricarboxylic acid		EC 3.2.1.166 (heparanase) inhibitor;
fungal metabolite
yw 3548[no description available]low00olefinic compound;
terpene lactone;
tertiary alcohol		fungal metabolite;
glycerophosphoinositol synthesis inhibitor
hypothemycin[no description available]low00aromatic ether;
diol;
enone;
epoxide;
macrolide;
phenols;
polyketide;
secondary alpha-hydroxy ketone		antifungal agent;
antineoplastic agent;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
fungal metabolite
HT-2 toxin[no description available]low00acetate ester;
organic heterotetracyclic compound;
trichothecene		apoptosis inducer;
fungal metabolite
tmc-95b[no description available]low00indoles;
lactam;
macrocycle;
phenols;
secondary alcohol;
tertiary alcohol		antimicrobial agent;
antineoplastic agent;
fungal metabolite;
proteasome inhibitor
sporothriolide[no description available]low00furofuran;
gamma-lactone		antifungal agent;
fungal metabolite
ascochlorin[no description available]low00cyclohexanones;
dihydroxybenzaldehyde;
meroterpenoid;
monochlorobenzenes;
olefinic compound;
resorcinols;
sesquiterpenoid		angiogenesis inhibitor;
antifungal agent;
antineoplastic agent;
antiprotozoal drug;
fungal metabolite
zaragozic acid c[no description available]low00acetate ester;
cyclic ketal;
oxabicycloalkane;
polyketide;
tertiary alcohol;
tricarboxylic acid		EC 2.5.1.21 (squalene synthase) inhibitor;
fungal metabolite
monascin[no description available]low00alpha,beta-unsaturated ketone;
gamma-lactone;
organic heterotricyclic compound;
polyketide		antilipemic drug;
antineoplastic agent;
fungal metabolite;
PPARgamma agonist
monascorubrin[no description available]low00azaphilone;
enone;
gamma-lactone;
polyketide;
triketone		anti-inflammatory agent;
antineoplastic agent;
biological pigment;
food colouring;
fungal metabolite;
Hsp90 inhibitor
5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4h-1-benzopyran-4-one[no description available]low00alkaloid;
chromones;
hydroxypiperidine;
resorcinols;
tertiary amino compound		anti-inflammatory agent;
anti-ulcer drug;
anticholesteremic drug;
antileishmanial agent;
antineoplastic agent;
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor;
fungal metabolite;
plant metabolite
ganodermadiol[no description available]low003beta-sterol;
primary allylic alcohol;
tetracyclic triterpenoid		antiviral agent;
fungal metabolite;
hepatoprotective agent
(3E,9E)-5,6-Dihydroxy-9,13,14-trimethyl-16-(2-methylpropyl)-17-azatricyclo[9.7.0.01,15]octadeca-3,9,12-triene-2,18-dione[no description available]low00cytochalasinfungal metabolite
prosomatostatin[no description available]low00heterodetic cyclic peptide;
peptide hormone		fungal metabolite;
mouse metabolite;
rat metabolite
depudecin[no description available]low00polyketideEC 3.5.1.98 (histone deacetylase) inhibitor;
fungal metabolite
diorcinol[no description available]low00aromatic ether;
phenols		fungal metabolite;
marine metabolite;
metabolite
antroquinonol d[no description available]low00enol ether;
enone;
secondary alcohol		antineoplastic agent;
fungal metabolite
equisetin[no description available]low00enol;
octahydronaphthalenes;
primary alcohol;
tetramic acids		antibacterial agent;
fungal metabolite;
HIV-1 integrase inhibitor;
quorum sensing inhibitor
hispidin[no description available]low002-pyranones;
catechols		antioxidant;
EC 2.7.11.13 (protein kinase C) inhibitor;
fungal metabolite
asperfuranone[no description available]low002-benzofurans;
cyclic ketone;
diol;
polyketide;
secondary alcohol;
tertiary alcohol;
tertiary alpha-hydroxy ketone		antineoplastic agent;
fungal metabolite
bassianolide[no description available]low00cyclodepsipeptide;
cyclooctadepsipeptide		antineoplastic agent;
fungal metabolite;
insecticide
ConditionIndicatedRelationship StrengthStudiesTrials
African Sleeping Sickness0low10
African Trypanosomiasis0low10
Aging0low10
Anemia, Fanconi0low10
Antibody Deficiency Syndrome0low10
Bilharziasis0low10
Carcinoma, Ehrlich Tumor0low20
Congenital Zika Syndrome0low10
Congenital Zika Virus Infection0low10
Contact Dermatitis0low10
Cytomegalovirus0low10
Deficiency Syndrome, Immunologic0low10
Deficiency Syndromes, Antibody0low10
Deficiency Syndromes, Immunologic0low10
Dermatitis Venenata0low10
Dermatitis, Contact0low10
Disease Models, Animal0low20
Eczema, Contact0low10
Ehrlich Ascites Tumor0low20
Experimental Leukemia0low10
Experimental Leukemias0low10
Experimental Neoplasms0low20
Fanconi Anemia0low10
Fanconi Hypoplastic Anemia0low10
Fanconi Pancytopenia0low10
Fanconi Panmyelopathy0low10
Fanconi's Anemia0low10
Fever, Zika0low10
Hypersensitivity, Contact0low10
Immunologic Deficiency Syndrome0low10
Immunologic Deficiency Syndromes0low10
Immunological Deficiency Syndromes0low10
Ischemia0low10
Itching0low10
Katayama Fever0low10
Leukemia L 12100low20
Leukemia L12100low20
Leukemia Model, Animal0low10
Leukemia P3880low10
Leukemia, Experimental0low10
Leukemias, Experimental0low10
Nagana0low10
Neoplasms, Experimental0low20
P388D(1) Leukemia0low10
Pruritis0low10
Pruritus0low10
Schistoma Infection0low10
Schistosomiasis0low10
Sensitivity, Contact0low10
Trypanosomiasis, African0low10
Zika Fever0low10
Zika Virus Disease0low10
Zika Virus Infection0low10
ZikV Infection0low10

Research Highlights

Dosage (2)

ArticleYear
Therapy of mouse leukemia L1210 with combinations of nebularine and nitrobenzylthioinosine 5'-monophosphate.
Cancer research, Volume: 41, Issue: 2		1981
Protection of mice against lethal dosages of nebularine by nitrobenzylthioinosine, an inhibitor of nucleoside transport.
Cancer research, Volume: 39, Issue: 9		1979
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Interactions (1)

ArticleYear
Treatment of schistosomiasis by purine nucleoside analogues in combination with nucleoside transport inhibitors.
Biochemical pharmacology, Nov-15, Volume: 36, Issue: 22		1987
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]