Premature Ejaculation

The emission of SEMEN and seminal fluid during the act of preparation for sexual intercourse, i.e. before there is penetration, or shortly after penetration.

Synonym
Premature Ejaculation

Excerpt	Reference
"Premature ejaculation is a frequent male sexual complaint or sexual disturbance found in urological practices and outpatient units."	( Brandt, AS; Degener, S; Mathers, MJ; Roth, S; Sommer, F, 2013)
"Premature ejaculation is a condition for which the cause is not well understood."	( Albersen, M; Castiglione, F; Giuliano, F; Gratzke, C; Hedlund, P; Salonia, A, 2016)
"Premature ejaculation is one of the most common sexual disorders in men due to uncontrolled modulation of spinal reflexes controlled by cortico-limbic centers in the brain."	( Abbas, S; Aslamkhan, M; Aydin, HH; Bhatti, S; Gonzalez, GR; Gonzalez, RMM; Khan, HL; Khan, YL, 2018)
"Premature ejaculation is the most common sexual dysfunction in young men, and it often leads to reduced relationship satisfaction and quality of life."	( Ågmo, A; Chu, X; Lehtimäki, J; Paredes, RG; Ventura-Aquino, E, 2021)
"Premature ejaculation is one of the common male sexual dysfunction diseases."	( Sun, J; Yang, DW, 2021)
"Premature ejaculation is the most common male sexual dysfunction, with therapies including selective serotonin reuptake inhibitors, clomipramine, topical anesthetics, dapoxetine and tramadol."	( Carto, C; Kulkarni, N; Madhusoodanan, V; Nackeeran, S; Ramasamy, R; Zucker, I, 2023)

Excerpt	Reference
"A total of 26 patients with untreated acquired premature ejaculation were enrolled."	( Amano, T; Araki, T; Haga, K; Honma, I; Kondou, N; Matsukawa, M; Otani, T; Sato, Y; Tobe, M; Uchida, K, 2017)
"GROUP A: The mean post-treatment Premature Ejaculation Diagnostic Tool (PEDT) score decreased from 12."	( Abbadessa, D; Gambino, G; Pavone, C; Scaduto, G; Vella, M, 2017)
"Use of sertraline to treat premature ejaculation needs to be tested in further RCTs."	( Anderson, P; Brown-Major, A; Ng, L; Sansom, J; Stratton, H, 2020)
"Pre- and post-treatment IELT, premature ejaculation profile (PEP), and International Index of Erectile Function-Erectile Function (IIEF-EF) scores of the patients were analyzed."	( Can, O; Culha, MG; Ermec, B; Onal, B, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	5 (2.37)	23.3326
1990's	0 (0.00)	12.5806
2000's	1 (0.47)	18.1394
2010's	153 (72.51)	28.8240
2020's	52 (24.64)	9.53

Drug	Relationship Strength	Studies	Trials
benzoic acid	low	1	0
bupropion	low	1	0
melatonin	medium	5	1
8-hydroxy-2-(di-n-propylamino)tetralin	low	2	0
amitriptyline	low	1	0
caffeine	medium	1	1
citalopram	medium	2	1
clomipramine	medium	4	2
fluoxetine	medium	9	2
guanethidine	low	2	0
haloperidol	low	1	0
imipramine	low	1	0
modafinil	low	2	0
naftopidil	medium	3	1
prilocaine	medium	5	2
thioridazine	low	4	0
trazodone	medium	1	1
glutamine	low	1	0
tryptophan	medium	2	1
thiophenes	medium	1	1
yohimbine	low	1	0
nuciferine	medium	1	1
s,n,n'-tripropylthiocarbamate	low	1	0
tramadol	medium	11	1
paroxetine	medium	22	8
fomesafen	low	1	0
duloxetine hydrochloride	medium	1	1
allicin	medium	1	1
triazoles	medium	7	4
sertraline	medium	19	11
dapoxetine	medium	62	22
diosgenin	medium	1	1
tadalafil	medium	8	4
tamsulosin	medium	3	3
benzofurans	medium	3	1
oxytocin	low	9	0
apigenin	medium	1	1
alprostadil	low	1	0
silodosin	medium	6	2
pregabalin	medium	1	1
resiniferatoxin	medium	7	1
radolmidine	low	1	0
psd 502	medium	4	1
tribulus	medium	1	1
epelsiban	medium	1	1
quetiapine fumarate	low	1	0
vitamin b 12	low	2	0
sildenafil citrate	medium	4	1
mirodenafil	medium	1	1
leptin	low	4	0
pyrimidinones	medium	1	1

Protein Targets (800)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
phosphopantetheinyl transferase	8	0	0	8
euchromatic histone-lysine N-methyltransferase 2	26	0	0	26
mu-type opioid receptor isoform MOR-1	0	0	1	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
5-hydroxytryptamine receptor 2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	6	3	0	9
Cytochrome P450 3A4	0	6	0	9
5-hydroxytryptamine receptor 1A	0	7	3	11
5-hydroxytryptamine receptor 2C	0	13	0	13
Neuronal acetylcholine receptor subunit alpha-4	0	2	0	2
Cytochrome P450 2C9	0	7	0	7
Neuronal acetylcholine receptor subunit beta-2	0	2	0	2
D(2) dopamine receptor	0	21	2	26
5-hydroxytryptamine receptor 2A	0	14	0	15
Gamma-aminobutyric acid receptor subunit beta-1	6	3	0	9
Alpha-1B adrenergic receptor	0	15	2	17
Translocator protein	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	6	3	0	9
Gamma-aminobutyric acid receptor subunit gamma-2	6	3	0	9
D	0	8	0	8
D(3) dopamine receptor	0	8	0	8
5-hydroxytryptamine receptor 1A	0	16	1	19
Alpha-2B adrenergic receptor	0	12	2	15
Gamma-aminobutyric acid receptor subunit alpha-5	6	3	0	9
Gamma-aminobutyric acid receptor subunit alpha-3	6	3	0	9
D(2) dopamine receptor	0	3	0	3
Alpha-2C adrenergic receptor	0	11	2	14
Alpha-2A adrenergic receptor	0	11	2	14
Gamma-aminobutyric acid receptor subunit gamma-1	6	3	0	9
Gamma-aminobutyric acid receptor subunit alpha-2	6	3	0	9
Alpha-1D adrenergic receptor	0	15	2	18
Sodium-dependent dopamine transporter	0	16	0	16
Alpha-1D adrenergic receptor	0	21	1	24
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	1	2
5-hydroxytryptamine receptor 2C	0	18	0	19
Gamma-aminobutyric acid receptor subunit alpha-4	6	3	0	9
Gamma-aminobutyric acid receptor subunit gamma-3	6	3	0	9
5-hydroxytryptamine receptor 1B	0	13	0	14
5-hydroxytryptamine receptor 1D	0	6	0	7
Gamma-aminobutyric acid receptor subunit alpha-6	6	3	0	9
5-hydroxytryptamine receptor 1F	0	6	0	7
5-hydroxytryptamine receptor 2B	0	13	0	13
Sodium-dependent serotonin transporter	0	13	1	14
5-hydroxytryptamine receptor 7	0	5	0	5
5-hydroxytryptamine receptor 7	0	6	0	6
Alpha-1A adrenergic receptor	0	9	2	13
Alpha-1B adrenergic receptor	0	9	2	13
5-hydroxytryptamine receptor 3A	0	4	0	4
Alpha-1A adrenergic receptor	0	19	2	21
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 6	0	13	0	13
5-hydroxytryptamine receptor 7	0	6	0	6
D(2) dopamine receptor	0	15	0	15
Gamma-aminobutyric acid receptor subunit alpha-1	6	3	0	9
Gamma-aminobutyric acid receptor subunit beta-3	6	3	0	9
Gamma-aminobutyric acid receptor subunit beta-2	6	3	0	9
D	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
GABA theta subunit	6	3	0	9
Sigma non-opioid intracellular receptor 1	0	19	0	19
Gamma-aminobutyric acid receptor subunit epsilon	6	3	0	9
5-hydroxytryptamine receptor 3B	0	4	0	4
Lysosomal alpha-glucosidase	0	2	0	2
Transporter	0	11	0	11
ATP-dependent phosphofructokinase	18	0	0	18
Transient receptor potential cation channel subfamily V member 1	0	1	1	2
Transient receptor potential cation channel subfamily A member 1	0	0	1	2
Procathepsin L	0	1	1	2
Cathepsin B	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Transient receptor potential cation channel subfamily V member 1	0	0	0	1
Cysteine protease	0	1	0	1
Mitochondrial 2-oxodicarboxylate carrier	0	1	0	1
TDP1 protein	14	0	0	14
AR protein	18	0	0	18
glucocorticoid receptor [Homo sapiens]	12	0	0	12
estrogen nuclear receptor alpha	20	0	0	20
peroxisome proliferator activated receptor gamma	10	0	0	10
ATP-binding cassette sub-family C member 3	0	18	0	18
Multidrug resistance-associated protein 4	0	18	0	19
Bile salt export pump	0	25	0	25
Cellular tumor antigen p53	11	0	0	11
Thromboxane-A synthase	0	1	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostacyclin receptor	0	1	1	2
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Canalicular multispecific organic anion transporter 1	0	17	0	17
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier organic anion transporter family member 3A1	0	0	0	1
Chain A, HADH2 protein	4	0	0	4
Chain B, HADH2 protein	4	0	0	4
thioredoxin reductase	16	0	0	16
USP1 protein, partial	13	0	0	13
NFKB1 protein, partial	6	0	0	6
GLS protein	14	0	0	14
cytochrome P450 family 3 subfamily A polypeptide 4	13	0	0	13
cytochrome P450 2D6	16	0	0	16
arylsulfatase A	11	0	0	11
cytochrome P450 2D6 isoform 1	8	0	0	8
D(1A) dopamine receptor	15	0	0	15
chromobox protein homolog 1	13	0	0	13
atrial natriuretic peptide receptor 2 precursor	7	0	0	7
serine/threonine-protein kinase mTOR isoform 1	10	0	0	10
nuclear factor erythroid 2-related factor 2 isoform 1	13	0	0	13
muscarinic acetylcholine receptor M1	9	0	0	9
Solute carrier family 22 member 1	0	6	0	6
Polyunsaturated fatty acid lipoxygenase ALOX15B	4	0	0	4
Voltage-dependent L-type calcium channel subunit alpha-1F	0	5	0	5
5-hydroxytryptamine receptor 4	0	16	0	16
Albumin	0	0	5	5
High affinity nerve growth factor receptor	0	1	2	3
Aldo-keto reductase family 1 member B1	0	17	0	17
Muscarinic acetylcholine receptor M2	0	11	0	11
Muscarinic acetylcholine receptor M4	0	11	0	11
Muscarinic acetylcholine receptor M1	0	4	0	4
Muscarinic acetylcholine receptor M3	0	4	0	4
Muscarinic acetylcholine receptor M4	0	4	0	4
Muscarinic acetylcholine receptor M5	0	5	0	5
Muscarinic acetylcholine receptor M5	0	14	0	14
Alpha-2A adrenergic receptor	0	18	1	19
Muscarinic acetylcholine receptor M2	0	4	0	4
Muscarinic acetylcholine receptor M1	0	14	0	14
Angiotensin-converting enzyme	0	14	0	14
Alpha-2B adrenergic receptor	0	16	0	16
Alpha-2C adrenergic receptor	0	15	0	15
Muscarinic acetylcholine receptor M3	0	11	0	11
D(1A) dopamine receptor	0	8	0	9
D(1B) dopamine receptor	0	3	0	4
UDP-glucuronosyltransferase 1A4	0	1	0	5
Sodium-dependent noradrenaline transporter	0	24	4	28
Histamine H2 receptor	0	8	0	8
5-hydroxytryptamine receptor 2A	0	16	0	17
5-hydroxytryptamine receptor 6	0	3	0	3
Histamine H1 receptor	0	6	0	6
Sodium-dependent serotonin transporter	0	25	5	30
5-hydroxytryptamine receptor 5A	0	3	0	3
5-hydroxytryptamine receptor 5B	0	3	0	3
Histamine H1 receptor	0	14	0	14
D(3) dopamine receptor	0	16	2	22
Sodium channel protein type 1 subunit alpha	0	3	0	3
Sodium channel protein type 4 subunit alpha	0	4	0	4
UDP-glucuronosyltransferase 1A3	0	0	0	2
5-hydroxytryptamine receptor 2B	0	16	0	17
Histamine H2 receptor	6	3	0	11
D(1A) dopamine receptor	8	1	0	9
Voltage-dependent N-type calcium channel subunit alpha-1B	0	3	0	3
Sodium channel protein type 7 subunit alpha	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	5	0	5
Sodium-dependent dopamine transporter	0	19	3	22
Potassium voltage-gated channel subfamily H member 2	0	19	0	19
Voltage-dependent L-type calcium channel subunit alpha-1S	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1C	0	7	0	7
Sodium channel protein type 5 subunit alpha	0	7	0	7
Sodium channel protein type 9 subunit alpha	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	3	1	4
5-hydroxytryptamine receptor 4	0	3	0	3
Nuclear receptor subfamily 3 group C member 3	0	12	0	12
Sodium channel protein type 2 subunit alpha	0	3	0	3
Ataxin-2	14	0	0	14
Sodium channel protein type 3 subunit alpha	0	4	0	4
Sodium channel protein type 11 subunit alpha	0	3	0	3
Sodium channel protein type 8 subunit alpha	0	3	0	3
Histamine H3 receptor	0	3	0	3
Sodium channel protein type 10 subunit alpha	0	3	0	3
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	8	0	0	8
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	5	0	0	5
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain A, Cruzipain	2	0	0	2
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain B, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain B, Transthyretin	0	0	1	1
Chain A, Casein kinase II subunit alpha	0	1	0	1
Chain A, Casein kinase II subunit alpha	0	1	0	1
Chain A, Casein Kinase Ii Subunit Alpha	0	1	0	1
Luciferase	4	0	0	4
interleukin 8	2	0	0	2
endonuclease IV	2	0	0	2
BRCA1	1	0	0	1
RGS12	1	0	0	1
15-lipoxygenase, partial	3	0	0	3
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
RAR-related orphan receptor gamma	15	0	0	15
ATAD5 protein, partial	10	0	0	10
PPM1D protein	3	0	0	3
GLI family zinc finger 3	15	0	0	15
Microtubule-associated protein tau	8	0	0	8
Thrombopoietin	3	0	0	3
Smad3	4	0	0	4
apical membrane antigen 1, AMA1	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	7	0	0	7
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
thyroid stimulating hormone receptor	9	0	0	9
estrogen receptor 2 (ER beta)	10	0	0	10
nuclear receptor subfamily 1, group I, member 3	14	0	0	14
progesterone receptor	12	0	0	12
regulator of G-protein signaling 4	11	0	0	11
EWS/FLI fusion protein	9	0	0	9
retinoic acid nuclear receptor alpha variant 1	17	0	0	17
retinoid X nuclear receptor alpha	8	0	0	8
estrogen-related nuclear receptor alpha	16	0	0	16
farnesoid X nuclear receptor	7	0	0	7
pregnane X nuclear receptor	12	0	0	12
G	9	0	0	9
Neuraminidase	0	2	0	2
67.9K protein	2	0	0	2
glucocerebrosidase	2	0	0	2
Parkin	2	0	0	2
peroxisome proliferator-activated receptor delta	7	0	0	7
vitamin D (1,25- dihydroxyvitamin D3) receptor	9	0	0	9
pyruvate kinase	1	0	0	1
IDH1	6	0	0	6
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
aryl hydrocarbon receptor	9	0	0	9
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	8	0	0	8
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	9	0	0	9
v-jun sarcoma virus 17 oncogene homolog (avian)	11	0	0	11
Histone H2A.x	6	0	0	6
Replicase polyprotein 1ab	0	1	1	2
NPC intracellular cholesterol transporter 1 precursor	6	0	0	6
peripheral myelin protein 22 isoform 1	6	0	0	6
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	2	0	0	2
cytochrome P450 2C19 precursor	4	0	0	4
cytochrome P450 2C9 precursor	3	0	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	4	0	0	4
thyroid hormone receptor beta isoform a	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
thyroid hormone receptor beta isoform 2	11	0	0	11
histone deacetylase 9 isoform 3	1	0	0	1
heat shock protein beta-1	4	0	0	4
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
mitogen-activated protein kinase 1	7	0	0	7
flap endonuclease 1	6	0	0	6
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	4	0	0	4
nuclear receptor ROR-gamma isoform 1	7	0	0	7
geminin	13	0	0	13
DNA polymerase kappa isoform 1	2	0	0	2
survival motor neuron protein isoform d	2	0	0	2
cytochrome P450 3A4 isoform 1	6	0	0	6
M-phase phosphoprotein 8	7	0	0	7
lamin isoform A-delta10	13	0	0	13
pyruvate kinase PKM isoform b	1	0	0	1
neuropeptide S receptor isoform A	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Polyphenol oxidase 2	0	2	0	2
Aldo-keto reductase family 1 member B10	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	5	0	0	5
G2/mitotic-specific cyclin-B2	0	1	0	1
Poly [ADP-ribose] polymerase tankyrase-1	0	1	0	1
Lysozyme C-1	0	1	0	1
Cationic trypsin	0	1	0	1
Carbonic anhydrase 1	0	4	0	8
Carbonic anhydrase 2	0	4	0	8
Interferon beta	13	0	0	13
HLA class I histocompatibility antigen, B alpha chain	9	0	0	9
Transthyretin	0	0	1	1
Estrogen receptor	0	1	0	1
Glucocorticoid receptor	0	0	0	1
Cytochrome P450 1A1	0	3	0	3
Amyloid-beta precursor protein	0	1	0	1
Integrin beta-3	1	0	0	1
Myeloperoxidase	0	5	0	5
Cytochrome P450 1A2	0	4	0	5
Cyclin-dependent kinase 1	0	1	0	1
Beta-glucuronidase	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	3
ATP-dependent translocase ABCB1	0	5	1	7
Neutrophil elastase	0	2	0	2
Integrin alpha-IIb	1	0	0	1
Ornithine decarboxylase	1	0	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Replicase polyprotein 1a	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	2	1	3
Replicase polyprotein 1ab	0	3	1	4
Androgen receptor	0	1	0	2
Sialidase	0	1	0	1
Serine/threonine-protein kinase pim-1	0	1	0	2
Aromatase	0	2	0	2
Cystic fibrosis transmembrane conductance regulator	0	1	2	3
17-beta-hydroxysteroid dehydrogenase type 1	0	1	0	1
Pyruvate kinase PKM	0	1	0	1
G2/mitotic-specific cyclin-B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Urease subunit alpha	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
G2/mitotic-specific cyclin-B	0	1	0	1
Mucin-1	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Glutamate receptor 2	5	0	0	5
Casein kinase II subunit alpha'	0	1	0	1
Amine oxidase [flavin-containing] A	0	3	0	3
Acetylcholinesterase	0	5	0	5
Carbonic anhydrase 4	0	1	0	3
Amine oxidase [flavin-containing] B	0	4	0	4
Dipeptidyl peptidase 4	0	1	0	1
Proteasome subunit beta type-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	2	0	2
Substance-P receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	0	2
Multidrug resistance-associated protein 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Mu-type opioid receptor	0	3	2	6
Receptor-type tyrosine-protein kinase FLT3	0	1	0	1
Testosterone 17-beta-dehydrogenase 3	0	1	0	1
17-beta-hydroxysteroid dehydrogenase type 2	0	1	0	1
Acetylcholinesterase	0	2	0	2
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Delta-type opioid receptor	0	1	0	2
Kappa-type opioid receptor	0	3	0	4
Homeobox protein Nkx-2.5	0	1	0	1
Tyrosine-protein kinase SYK	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-2	0	2	0	2
Xanthine dehydrogenase/oxidase	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Glycogen synthase kinase-3 alpha	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Estrogen receptor	0	0	1	1
Nuclear receptor ROR-gamma	2	0	0	2
Death-associated protein kinase 1	0	1	0	1
Mitogen-activated protein kinase 10	0	1	0	1
Beta-secretase 1	0	1	0	2
Casein kinase II subunit beta	0	1	0	1
Casein kinase II subunit alpha	0	2	0	2
Urease subunit beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Lactoperoxidase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
MO15-related protein kinase Pfmrk	0	1	0	1
Inositol monophosphatase 1	3	0	0	3
Cyclin-dependent kinase 6	0	1	0	1
Cyclin-dependent-like kinase 5	0	1	0	1
Cyclin homolog	0	1	0	1
Transcription factor GATA-4	0	1	0	1
Cyclin-dependent kinase 5 activator 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	0	2
Mitogen-activated protein kinase 14	0	1	0	1
Cytochrome P450 1B1	0	4	0	4
Carbonic anhydrase 3	0	1	0	1
Substance-K receptor	0	1	0	1
Reverse transcriptase/RNaseH	0	1	0	1
Integrase	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Casein kinase II subunit alpha 3	0	1	0	1
Inositol polyphosphate multikinase	0	1	0	1
G2/mitotic-specific cyclin-B3	0	1	0	1
Inositol hexakisphosphate kinase 1	9	0	0	9
Estrogen receptor beta	0	1	0	1
Enoyl-acyl-carrier protein reductase	0	1	0	1
Aurora kinase B	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
ATPase family AAA domain-containing protein 5	6	0	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Myocilin	0	0	1	1
Cyclin-dependent kinase 1	0	1	0	1
Prenyltransferase homolog	0	0	0	1
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
MAP kinase-interacting serine/threonine-protein kinase 2	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
NADPH oxidase 4	0	1	0	1
Dipeptidyl peptidase 3	0	1	0	1
Estrogen receptor beta	0	0	1	1
Inositol hexakisphosphate kinase 2	0	1	0	1
Short transient receptor potential channel 5	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	3
Sialidase-2	0	1	0	1
cytochrome P450 2C9, partial	9	0	0	9
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	2	0	0	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
alpha-galactosidase	2	0	0	2
lethal factor (plasmid)	5	0	0	5
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, brain	0	1	0	3
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	4
Cationic amino acid transporter 3	0	1	0	1
glp-1 receptor, partial	5	0	0	5
thyroid stimulating hormone receptor	8	0	0	8
TAR DNA-binding protein 43	2	0	0	2
Chain A, Oxygen-insensitive Nad(p)h Nitroreductase	0	1	0	1
Chain B, Oxygen-insensitive Nad(p)h Nitroreductase	0	1	0	1
acetylcholinesterase	7	0	0	7
D-amino-acid oxidase	0	0	1	1
Tyrosinase	0	1	0	1
D-amino-acid oxidase	0	2	1	3
Metabotropic glutamate receptor 5	0	0	1	1
Alpha-glucosidase MAL12	0	1	0	1
Monocarboxylate transporter 1	0	0	0	1
Beta-lactamase	0	1	1	2
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
D-aspartate oxidase	0	1	0	1
Serine racemase	0	1	0	1
histone acetyltransferase KAT2A isoform 1	5	0	0	5
Acetylcholine receptor subunit alpha	0	1	0	1
Acetylcholine receptor subunit gamma	0	1	0	1
Integrin alpha-5	0	1	0	1
Acetylcholine receptor subunit beta	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	2	0	3
Neuronal acetylcholine receptor subunit beta-2	0	1	0	2
UDP-glucuronosyltransferase 1-6	0	1	0	1
Cytochrome P450 2B6	0	0	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Cytochrome P450 2C19	0	6	0	7
UDP-glucuronosyltransferase 2B10	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	2
Acetylcholine receptor subunit delta	0	1	0	1
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	3	0	0	3
DNA polymerase beta	1	0	0	1
Potassium channel subfamily K member 2	0	3	1	4
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	1	0	1
Cholinesterase	0	2	0	2
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Adenosine receptor A3	0	1	0	1
Adenosine receptor A1	0	3	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	3	0	3
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	2	1	4
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	2	0	3
Adenosine receptor A1	0	1	1	4
Adenosine receptor A2a	0	2	0	4
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	2	2	4
Endochitinase B1	0	1	0	1
Muscarinic acetylcholine receptor	0	0	0	1
Phosphodiesterase	0	1	0	1
Guanine deaminase	0	1	0	1
Sodium-dependent noradrenaline transporter	0	4	0	4
Tryptophan 5-hydroxylase 1	0	3	0	3
Aldo-keto reductase family 1 member B1	0	2	0	2
Aromatase	0	1	0	1
Spike glycoprotein	12	0	1	13
Sigma intracellular receptor 2	0	6	0	6
Sodium-dependent serotonin transporter	0	4	0	4
Sodium-dependent dopamine transporter	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	7	0	7
Fumarate hydratase	8	0	0	8
caspase 7, apoptosis-related cysteine protease	7	0	0	7
polyprotein	8	0	0	8
caspase-3	7	0	0	7
Spike glycoprotein	0	0	1	1
potassium voltage-gated channel subfamily H member 2 isoform d	11	0	0	11
peripheral myelin protein 22	8	0	0	8
Transmembrane protease serine 2	0	0	1	1
Cytochrome P450 2D6	0	13	0	13
Trypanothione reductase	0	2	0	2
Trypanothione reductase	0	1	0	1
Proteasome subunit alpha type-6	0	0	2	2
Envelope glycoprotein	0	0	4	4
Angiotensin-converting enzyme 2	0	0	1	1
SMAD family member 2	1	0	0	1
SMAD family member 3	1	0	0	1
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
Alpha-synuclein	1	0	0	1
Vasopressin V2 receptor	0	2	1	3
Oxytocin receptor	0	4	2	6
Vasopressin V1a receptor	0	3	1	4
Vasopressin V1b receptor	0	2	1	3
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
huntingtin isoform 2	2	0	0	2
ras-related protein Rab-9A	5	0	0	5
Sodium channel protein type 1 subunit alpha	0	3	0	3
Cytochrome P450 2C8	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Acetylcholinesterase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
Cytochrome P450 2J2	0	5	0	5
Gastrin/cholecystokinin type B receptor	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
Transporter	0	3	0	3
Beta-2 adrenergic receptor	0	1	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
Bloom syndrome protein isoform 1	5	0	0	5
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	2
Amino acid transporter	0	1	0	1
nonstructural protein 1	2	0	0	2
Adenylate cyclase type 1	0	1	0	1
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Cocaine esterase	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
UDP-glucuronosyltransferase 1A9	0	1	0	2
Major prion protein	0	0	2	2
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Beta-2 adrenergic receptor	0	2	0	2
Integrin alpha-4	0	1	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
Beta-1 adrenergic receptor	0	2	0	2
D(4) dopamine receptor	0	7	1	10
Adenylate cyclase type 3	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
D(1B) dopamine receptor	0	7	0	7
Beta-3 adrenergic receptor	0	1	0	1
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
D(4) dopamine receptor	0	7	0	7
C-8 sterol isomerase	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	3	0	3
5-hydroxytryptamine receptor 2C	0	2	0	2
Kappa-type opioid receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	3
Adenylate cyclase type 8	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	3
Glutamate receptor ionotropic, NMDA 2B	0	2	0	3
Glutamate receptor ionotropic, NMDA 2C	0	2	0	3
5-hydroxytryptamine receptor 2B	0	1	0	1
Adenylate cyclase type 6	0	1	0	1
Adenylate cyclase type 5	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Zinc finger protein 664	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	2	0	3
Vesicular acetylcholine transporter	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Protease	0	2	0	2
Adenylyl cyclase 7	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	0	3
D	0	2	0	2
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	0	3
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
hypothetical protein, conserved	1	0	0	1
vitamin D3 receptor isoform VDRA	2	0	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	2	0	2
Snq2p	0	0	0	2
activating transcription factor 6	2	0	0	2
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Sphingomyelin phosphodiesterase	0	1	0	1
Pleiotropic ABC efflux transporter of multiple drugs	0	2	0	4
D(2) dopamine receptor	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Multidrug and toxin extrusion protein 1	0	2	0	2
Solute carrier family 22 member 2	0	1	0	1
Bile salt export pump	0	2	0	2
Amine oxidase [flavin-containing] B	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Chain A, Beta-lactamase	3	0	0	3
Potassium channel subfamily K member 3	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
ClpP	2	0	0	2
Cytochrome P450 1A2	0	1	0	1
Cytochrome P450 2C11	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Carboxylic ester hydrolase	0	1	0	1
POU domain, class 2, transcription factor 1	0	0	0	1
thioredoxin glutathione reductase	2	0	0	2
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	0	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	2
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	0	0	1
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
voltage-dependent T-type calcium channel subunit alpha-1H isoform a	0	0	1	1
Beta-2 adrenergic receptor	0	1	0	1
Vasopressin V1a receptor	0	1	0	1
Vasopressin V1b receptor	0	1	0	1
Oxytocin receptor	0	1	0	1
Oxytocin receptor	0	0	1	1
Vasopressin V2 receptor	0	1	0	1
Quinolone resistance protein NorA	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	1	2
Substance-P receptor	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
P2X purinoceptor 4	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
P2X purinoceptor 4	0	1	0	1
Beta-adrenergic receptor kinase 1	0	0	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Transcriptional activator protein LuxR	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Melanocortin receptor 5	0	2	0	2
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Carbonic anhydrase 12	0	1	0	3
cGMP-specific 3',5'-cyclic phosphodiesterase	0	3	1	4
Carbonic anhydrase 3	0	1	0	3
Carbonic anhydrase 6	0	1	0	3
Carbonic anhydrase 5A, mitochondrial	0	1	0	3
Carbonic anhydrase 7	0	1	0	3
Carbonic anhydrase 9	0	1	0	4
Carbonic anhydrase 13	0	0	0	2
Carbonic anhydrase 14	0	0	0	2
Carbonic anhydrase 5B, mitochondrial	0	1	0	3
Alpha-1A adrenergic receptor	0	2	1	3
Potassium voltage-gated channel subfamily E member 1	0	2	0	2
Potassium voltage-gated channel subfamily KQT member 1	0	2	0	2
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Carbonic anhydrase	0	1	0	2
Mu-type opioid receptor	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase 4	0	1	0	1
Carbonic anhydrase 15	0	1	0	2
D(2) dopamine receptor	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain B, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Phosphodiesterase	0	1	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	1	2
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	1	1
Alpha-1A adrenergic receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
GALC protein	1	0	0	1
Epidermal growth factor receptor	0	1	0	1
Albumin	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Cathepsin D	0	1	0	1
Aldehyde oxidase	0	0	0	2
Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Dihydrofolate reductase	0	2	0	2
Plasma kallikrein	0	0	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Stromelysin-1	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Carbonic anhydrase	0	0	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
Large neutral amino acids transporter small subunit 1	0	1	0	1
SLC16A10 protein	0	0	0	1
Tryprostatin B synthase	0	0	0	1
Carbonic anhydrase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Monocarboxylate transporter 10	0	0	0	1
Phospholipase A-2-activating protein	0	1	0	1
POsterior Segregation	0	0	1	1
Estrogen receptor beta	0	1	0	1
DNA topoisomerase 1	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Estrogen receptor	0	1	0	1
M-phase inducer phosphatase 1	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Zinc finger protein mex-5	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (211)

Protein Targets (800)

Premature Ejaculation

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (211)

Drugs Studied (67)

Protein Targets (800)