| Assay ID | Title | Year | Journal | Article |
|---|
| AID343109 | Activity at GABAA alpha-3-beta-3-gamma-2 receptor expressed in Xenopus oocytes assessed as potentiation of GABA-induced chloride current at 1 uM | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13
| Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit. |
| AID1604585 | Negative allosteric modulation of GABA-A alpha1 (unknown origin) assessed as reduction in DMCM induced current relative to control | | | |
| AID1604591 | Selectivity ratio of Ki for binding affinity to GABAA alpha3beta3gamma2 (unknown origin) to Ki for binding affinity to GABAA alpha5beta3gamma2 (unknown origin) | | | |
| AID343107 | Activity at GABAA alpha-4-beta-3-gamma-2 receptor expressed in Xenopus oocytes assessed as potentiation of GABA-induced chloride current at 1 uM | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13
| Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit. |
| AID71268 | Binding affinity against Gamma-aminobutyric acid A receptor alpha-6-beta-3-gamma-2 | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21
| Predictive models for GABAA/benzodiazepine receptor subtypes: studies of quantitative structure-activity relationships for imidazobenzodiazepines at five recombinant GABAA/benzodiazepine receptor subtypes [alphaxbeta3gamma2 (x = 1-3, 5, and 6)] via compar |
| AID219794 | Binding affinity against alpha-1-beta-3-gamma-2 GABAA/BzR receptor subtype. | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21
| Predictive models for GABAA/benzodiazepine receptor subtypes: studies of quantitative structure-activity relationships for imidazobenzodiazepines at five recombinant GABAA/benzodiazepine receptor subtypes [alphaxbeta3gamma2 (x = 1-3, 5, and 6)] via compar |
| AID343096 | Binding affinity to GABAA alpha-6-beta-3-gamma-2 receptor | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13
| Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit. |
| AID343094 | Binding affinity to GABAA alpha-3-beta-3-gamma-2 receptor | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13
| Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit. |
| AID1604600 | Negative allosteric modulation of GABAA alpha5beta3gamma2 (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current response at -60 mV holding potential by two electrode voltage clamp method relative to control | | | |
| AID343103 | Selectivity for GABAA alpha-5-beta-3-gamma-2 receptor over GABAA alpha-6-beta-3-gamma-2 receptor | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13
| Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit. |
| AID343093 | Binding affinity to GABAA alpha-2-beta-3-gamma-2 receptor | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13
| Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit. |
| AID73523 | Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-5-beta-3-gamma-2 | 2000 | Journal of medicinal chemistry, Jan-13, Volume: 43, Issue:1
| Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach. |
| AID533782 | Binding affinity to human recombinant GABA alpha-5-beta-3-gamma-2 receptor | 2010 | Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22
| The GABA(A) receptor as a target for photochromic molecules. |
| AID343106 | Activity at GABAA alpha-2-beta-3-gamma-2 receptor expressed in Xenopus oocytes assessed as potentiation of GABA-induced chloride current at 1 uM | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13
| Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit. |
| AID343102 | Selectivity for GABAA alpha-5-beta-3-gamma-2 receptor over GABAA alpha-4-beta-3-gamma-2 receptor | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13
| Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit. |
| AID533781 | Binding affinity to human recombinant GABA alpha-4-beta-3-gamma-2 receptor | 2010 | Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22
| The GABA(A) receptor as a target for photochromic molecules. |
| AID1604586 | Binding affinity to GABA-A alpha2 (unknown origin) assessed as reduction in DMCM induced current relative to control | | | |
| AID1604528 | Binding affinity to GABA-A alpha2 (unknown origin) | | | |
| AID343402 | Binding affinity to GABAA alpha-1-beta-3-gamma-2 receptor | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13
| Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit. |
| AID71266 | Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2 | 2000 | Journal of medicinal chemistry, Jan-13, Volume: 43, Issue:1
| Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach. |
| AID219795 | It is the ratio of Ki value for alpha-1-beta-3-gamma-2 to that of alpha-5-beta-3-gamma-2 | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21
| Predictive models for GABAA/benzodiazepine receptor subtypes: studies of quantitative structure-activity relationships for imidazobenzodiazepines at five recombinant GABAA/benzodiazepine receptor subtypes [alphaxbeta3gamma2 (x = 1-3, 5, and 6)] via compar |
| AID71699 | Binding affinity against Diazepam sensitive (DS) Gamma-aminobutyric acid A receptor | 1995 | Journal of medicinal chemistry, May-12, Volume: 38, Issue:10
| Synthesis of novel imidazobenzodiazepines as probes of the pharmacophore for "diazepam-insensitive" GABAA receptors. |
| AID219954 | Binding affinity against alpha-3-beta-3-gamma-2 GABAA/BzR receptor subtype. | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21
| Predictive models for GABAA/benzodiazepine receptor subtypes: studies of quantitative structure-activity relationships for imidazobenzodiazepines at five recombinant GABAA/benzodiazepine receptor subtypes [alphaxbeta3gamma2 (x = 1-3, 5, and 6)] via compar |
| AID73089 | Binding affinity to human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-2-beta-3-gamma-2 | 2000 | Journal of medicinal chemistry, Jan-13, Volume: 43, Issue:1
| Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach. |
| AID343110 | Inhibition of scopolamine-induced impairment of contextual memory in C57BL/6J mouse at 10 mg/kg, ip after 24 hrs | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13
| Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit. |
| AID72132 | Binding affinity against Diazepam insensitive (DI) Gamma-aminobutyric acid A receptor | 1995 | Journal of medicinal chemistry, May-12, Volume: 38, Issue:10
| Synthesis of novel imidazobenzodiazepines as probes of the pharmacophore for "diazepam-insensitive" GABAA receptors. |
| AID1604590 | Selectivity ratio of Ki for binding affinity to GABAA alpha2beta3gamma2 (unknown origin) to Ki for binding affinity to GABAA alpha5beta3gamma2 (unknown origin) | | | |
| AID343095 | Binding affinity to GABAA alpha-4-beta-3-gamma-2 receptor | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13
| Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit. |
| AID343101 | Selectivity for GABAA alpha-5-beta-3-gamma-2 receptor over GABAA alpha-3-beta-3-gamma-2 receptor | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13
| Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit. |
| AID343403 | Binding affinity to GABAA alpha-5-beta-3-gamma-2 receptor | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13
| Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit. |
| AID533779 | Binding affinity to human recombinant GABA alpha-2-beta-3-gamma-2 receptor | 2010 | Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22
| The GABA(A) receptor as a target for photochromic molecules. |
| AID1604589 | Selectivity ratio of Ki for binding affinity to GABAA alpha1beta3gamma2 (unknown origin) to Ki for binding affinity to GABAA alpha5beta3gamma2 (unknown origin) | | | |
| AID1604588 | Binding affinity to GABA-A alpha5 (unknown origin) assessed as reduction in DMCM induced current relative to control | | | |
| AID343104 | Activity at GABAA alpha-5-beta-3-gamma-2 receptor expressed in Xenopus oocytes assessed as assessed as inhibition in GABA-induced current at 1 uM by voltage clamp assay | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13
| Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit. |
| AID533778 | Binding affinity to human recombinant GABA alpha-1-beta-3-gamma-2 receptor | 2010 | Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22
| The GABA(A) receptor as a target for photochromic molecules. |
| AID1604530 | Binding affinity to GABA-A alpha3 (unknown origin) | | | |
| AID73244 | Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-3-beta-3-gamma-2 | 2000 | Journal of medicinal chemistry, Jan-13, Volume: 43, Issue:1
| Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach. |
| AID72927 | Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-1-beta-3-gamma-2 | 2000 | Journal of medicinal chemistry, Jan-13, Volume: 43, Issue:1
| Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach. |
| AID1604587 | Binding affinity to GABA-A alpha3 (unknown origin) assessed as reduction in DMCM induced current relative to control | | | |
| AID219940 | Binding affinity tested against alpha-2-beta-3-gamma-2 GABAA/BzR receptor subtype. | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21
| Predictive models for GABAA/benzodiazepine receptor subtypes: studies of quantitative structure-activity relationships for imidazobenzodiazepines at five recombinant GABAA/benzodiazepine receptor subtypes [alphaxbeta3gamma2 (x = 1-3, 5, and 6)] via compar |
| AID343099 | Selectivity for GABAA alpha-5-beta-3-gamma-2 receptor over GABAA alpha-1-beta-3-gamma-2 receptor | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13
| Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit. |
| AID1604531 | Binding affinity to GABA-A alpha5 (unknown origin) | | | |
| AID1604529 | Binding affinity to GABA-A alpha1 (unknown origin) | | | |
| AID343404 | Anticonvulsant activity in C57BL/6J mouse assessed as inhibition of increase in excitatory tone in brain at 30 mg/kg, ip | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13
| Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit. |
| AID343105 | Activity at GABAA alpha-1-beta-3-gamma-2 receptor expressed in Xenopus oocytes assessed as potentiation of GABA-induced chloride current at 1 uM | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13
| Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit. |
| AID343100 | Selectivity for GABAA alpha-5-beta-3-gamma-2 receptor over GABAA alpha-2-beta-3-gamma-2 receptor | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13
| Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit. |
| AID533780 | Binding affinity to human recombinant GABA alpha-3-beta-3-gamma-2 receptor | 2010 | Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22
| The GABA(A) receptor as a target for photochromic molecules. |
| AID73530 | Binding affinity for Gamma-aminobutyric acid A receptor alpha-5-beta-3-gamma-2 | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21
| Predictive models for GABAA/benzodiazepine receptor subtypes: studies of quantitative structure-activity relationships for imidazobenzodiazepines at five recombinant GABAA/benzodiazepine receptor subtypes [alphaxbeta3gamma2 (x = 1-3, 5, and 6)] via compar |
| AID232720 | Selectivity ratio of alpha1 beta-3 gamma2 GABA A / BzR and alpha5 beta-3 gamma2 GABA A / BzR | 2000 | Journal of medicinal chemistry, Jan-13, Volume: 43, Issue:1
| Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach. |
| AID343108 | Activity at GABAA alpha-6-beta-3-gamma-2 receptor expressed in Xenopus oocytes assessed as potentiation of GABA-induced chloride current at 1 uM | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13
| Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |