benzene oxide: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 10942345 |
| MeSH ID | M0080572 |
| Synonym |
|---|
| ccris 2979 |
| benzene oxide |
| benzeneoxide |
| brn 1236712 |
| dihydroepoxybenzene |
| 1488-25-1 |
| 5-17-01-00475 (beilstein handbook reference) |
| v2wdi94m5s , |
| unii-v2wdi94m5s |
| Q27896514 |
| (1s,6r)-7-oxabicyclo[4.1.0]hepta-2,4-diene |
| Excerpt | Reference | Relevance |
|---|---|---|
| "1 0)undeca-1,6-diene, a stable bridge-head diene analog of sym-oxepin oxide, were toxic but not mutagenic in both assays." | ( Structure-activity relationships in the mutagenicity and cytotoxicity of putative metabolites and related analogs of benzene derived from the valence tautomers benzene oxide and oxepin. Rastetter, WH; Stark, AA, 1996) | 0.29 |
We used adducts of hemoglobin (Hb) and bone marrow proteins to study the disposition of three benzene and metabolites. The production of BO has never been unambiguously confirmed in animals dosed with benzene.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We were able to detect SPC in the hemoglobin of exposed rats and mice, to show the linearity of the exposure dose-response relationship, and to establish the sensitivity limits of this assay." | ( S-phenylcysteine formation in hemoglobin as a biological exposure index to benzene. Bechtold, WE; Birnbaum, LS; Henderson, RF; Kasicki, S; Li, GL; Lucier, G; Sun, JD; Yin, SN, 1992) | 0.28 |
| " The analysis of Hb adducts of BO from rats dosed with 50-400 mg/kg [13C6]benzene via this method resulted in values which were generally consistent, though slightly lower, than those obtained using an established method." | ( Analysis of hemoglobin adducts of benzene oxide by gas chromatography-mass spectrometry. McDonald, TA; Rappaport, SM; Yeowell-O'Connell, K, 1996) | 0.29 |
| " We used adducts of hemoglobin (Hb) and bone marrow proteins to study the disposition of three benzene and metabolites (benzene oxide [BO], 1,2-benzoquinone [1,2-BQ], and 1,4-benzoquinone [1,4-BQ]) in F344 rats and B6C3F1 mice following a single oral dosage of [13C6]benzene and/or [14C]benzene." | ( The use of protein adducts to investigate the disposition of reactive metabolites of benzene. McDonald, TA; Rappaport, SM; Yeowell-O'Connell, K, 1996) | 0.29 |
| "Although it is generally assumed that metabolism of benzene proceeds through an initial step involving oxidation to benzene oxide (BO) by CYP450 in the liver, the production of BO has never been unambiguously confirmed in animals dosed with benzene." | ( Measurement of benzene oxide in the blood of rats following administration of benzene. Golding, BT; Lindstrom, AB; Rappaport, SM; Tornero-Velez, R; Waidyanatha, S; Yeowell-O'Connell, K, 1997) | 0.3 |
| " This assay was employed to quantitate mono-S-substituted background adducts in human and rat Hb and Alb and benzene-specific adducts in Hb and Alb from F344 rats following a single oral dosage of 50-400 mg [13C6]benzene/kg body wt." | ( A new assay for albumin and hemoglobin adducts of 1,2- and 1,4-benzoquinones. Rappaport, SM; Waidyanatha, S; Yeowell-O'Connell, K, 1998) | 0.3 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (5.88) | 18.7374 |
| 1990's | 14 (41.18) | 18.2507 |
| 2000's | 12 (35.29) | 29.6817 |
| 2010's | 6 (17.65) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 34 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||