Page last updated: 2024-12-07

rhc 3164

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

7-chloro-5-propyl-1,2,4-triazolo(4,3-a)quinoxaline-1,4(2H,5H)-dione: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	133527
CHEMBL ID	121101
MeSH ID	M0120009

Synonyms (9)

Synonym
rev 3164
(1,2,4)triazolo(4,3-a)quinoxaline-1,4(2h,5h)-dione, 7-chloro-5-propyl-
7-chloro-5-propyl-1,2,4-triazolo(4,3-a)quinoxaline-1,4(2h,5h)-dione
rhc-3164
rev-3164
rhc 3164
CHEMBL121101
80708-33-4
DTXSID90230516

Research Excerpts

Effects

Excerpt	Reference	Relevance
"RHC 3164 has been investigated for its antiallergic activities in 3 in vitro models of anaphylaxis. "	( Antiallergic activity profiles in vitro of RHC 3164 and related compounds. II. Comparison of RHC 3164 with disodium cromoglycate. Dally-Meade, V; Huang, F; Jariwala, N; Khandwala, A, 1984)	1.97

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (6)

Assay ID	Title	Year	Journal	Article
AID185586	Percent inhibitory activity in rat passive cutaneous anaphylaxis test at a dose of 25 mg/kg administered perorally	1985	Journal of medicinal chemistry, Mar, Volume: 28, Issue:3	1,2,4-Triazolo[4,3-a]quinoxaline-1,4-diones as antiallergic agents.
AID1859262	Inhibition of IgE-mediated passive cutaneous anaphylaxis in rat when administered orally	2022	European journal of medicinal chemistry, Feb-05, Volume: 229	Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities.
AID1859261	Inhibition of IgE-mediated passive cutaneous anaphylaxis in rat at 25 mg/kg, po	2022	European journal of medicinal chemistry, Feb-05, Volume: 229	Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities.
AID181354	Concentration required to inhibit Antigen-induced release of Histamine from rat mast cells	1985	Journal of medicinal chemistry, Mar, Volume: 28, Issue:3	1,2,4-Triazolo[4,3-a]quinoxaline-1,4-diones as antiallergic agents.
AID1859258	Inhibition of antigen-induced release of histamine (AIR) from rat peritoneal mast cells (RMC)	2022	European journal of medicinal chemistry, Feb-05, Volume: 229	Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities.
AID177829	Effective dose against IgE-mediated cutaneous anaphylaxis in the rat after peroral administration	1985	Journal of medicinal chemistry, Mar, Volume: 28, Issue:3	1,2,4-Triazolo[4,3-a]quinoxaline-1,4-diones as antiallergic agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	5 (83.33)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (16.67)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.50

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.50 (24.57)
Research Supply Index	1.95 (2.92)
Research Growth Index	4.45 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.50)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (16.67%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (83.33%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
celecoxib [no description available]	3.51	1	organofluorine compound; pyrazoles; sulfonamide; toluenes	cyclooxygenase 2 inhibitor; geroprotector; non-narcotic analgesic; non-steroidal anti-inflammatory drug
ibuprofen Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine	3.51	1	monocarboxylic acid	antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; drug allergen; environmental contaminant; geroprotector; non-narcotic analgesic; non-steroidal anti-inflammatory drug; radical scavenger; xenobiotic
moclobemide Moclobemide: A reversible inhibitor of monoamine oxidase type A; (RIMA); (see MONOAMINE OXIDASE INHIBITORS) that has antidepressive properties.. moclobemide : A member of the class of benzamides that is benzamide substituted by a chloro group at position 4 and a 2-(morpholin-4-yl)ethyl group at the nitrogen atom. It acts as a reversible monoamine oxidase inhibitor and is used in the treatment of depression.	3.51	1	benzamides; monochlorobenzenes; morpholines	antidepressant; environmental contaminant; xenobiotic
clorgyline Clorgyline: An antidepressive agent and monoamine oxidase inhibitor related to PARGYLINE.. clorgyline : An aromatic ether that is the 2,4-dichlorophenyl ether of 3-aminopropan-1-ol in which the nitrogen is substituted by a methyl group and a prop-1-yn-3-yl group. A monoamine oxidase inhibitor, it was formerly used as an antidepressant.	3.51	1	aromatic ether; dichlorobenzene; terminal acetylenic compound; tertiary amino compound	antidepressant; EC 1.4.3.4 (monoamine oxidase) inhibitor
quinoxalines quinoxaline : A naphthyridine in which the nitrogens are at positions 1 and 4.	1.96	1	mancude organic heterobicyclic parent; naphthyridine; ortho-fused heteroarene
2-methylquinoxaline 2-methylquinoxaline: structure given in first source. 2-methylquinoxaline : A quinoxaline derivative in which the quinoxaline (1,4-naphthyridine) skeleton is substituted at C-2 with a methyl group.	3.51	1	quinoxaline derivative
cromolyn sodium Cromolyn Sodium: A chromone complex that acts by inhibiting the release of chemical mediators from sensitized MAST CELLS. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.. disodium cromoglycate : An organic sodium salt that is the disodium salt of cromoglycic acid.	4	4	organic sodium salt	anti-asthmatic drug; drug allergen
acarbose [no description available]	3.51	1	tetrasaccharide derivative	EC 3.2.1.1 (alpha-amylase) inhibitor; EC 3.2.1.20 (alpha-glucosidase) inhibitor; geroprotector; hypoglycemic agent
triazoles Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.	2.88	4	1,2,3-triazole
p-methoxy-n-methylphenethylamine p-Methoxy-N-methylphenethylamine: A potent mast cell degranulator. It is involved in histamine release.. N,O-dimethyltyramine : A secondary amino compound that is tyramine in which the hydrogen of the phenolic hydroxy group has been replaced by a methyl group.	1.96	1	aromatic ether; secondary amino compound	metabolite
sorafenib [no description available]	3.51	1	(trifluoromethyl)benzenes; aromatic ether; monochlorobenzenes; phenylureas; pyridinecarboxamide	angiogenesis inhibitor; anticoronaviral agent; antineoplastic agent; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; ferroptosis inducer; tyrosine kinase inhibitor
ovalbumin Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.	1.96	1
6-cyano-7-nitroquinoxaline-2,3-dione 6-Cyano-7-nitroquinoxaline-2,3-dione: A potent excitatory amino acid antagonist with a preference for non-NMDA iontropic receptors. It is used primarily as a research tool.	3.51	1	quinoxaline derivative
fg 9041 FG 9041: structure given in first source	3.51	1	quinoxaline derivative
lofepramine hydrochloride [no description available]	3.51	1
tqx 173 [no description available]	3.51	1
calcimycin Calcimycin: An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.	1.96	1	benzoxazole
LSM-2536 [no description available]	3.51	1	piperazines
N-[2-(3-oxo-4H-quinoxalin-2-yl)-4-propan-2-ylphenyl]-2-thiophenecarboxamide [no description available]	3.51	1	aromatic amide

Condition	Relationship Strength	Studies
Allergic Reaction [description not available]	2.65	3
Hypersensitivity Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.	2.65	3
Asthma, Bronchial [description not available]	1.96	1
Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).	1.96	1

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