Compounds > 4-thioxothiazolidin-2-one
Page last updated: 2024-12-09

4-thioxothiazolidin-2-one

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

4-thioxothiazolidin-2-one: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID1539595
CHEMBL ID539408
SCHEMBL ID441899
MeSH IDM0445662

Synonyms (18)

Synonym
4-sulfanylidene-1,3-thiazolidin-2-one
AKOS000267509
CHEMBL539408
STL257481
FT-0688749
4-thioxo-1,3-thiazolidin-2-one
4303-29-1
4-thioxothiazolidin-2-one
thiazolidine-2-one-4-thione
XTSVDOIDJDJMDS-UHFFFAOYSA-N
2-oxo-4-thioxothiazolidine
SCHEMBL441899
mfcd02167269
mercaptothiazolinone
isorhodanine
CS-0088269
D74680
EN300-78446
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (27)

Assay IDTitleYearJournalArticle
AID420221Antimicrobial activity against multidrug-resistant Staphylococcus aureus H.C. 20489 isolate after 20 hrs by twofold serial dilution technique2009European journal of medicinal chemistry, May, Volume: 44, Issue:5
Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.
AID420222Antimicrobial activity against multidrug-resistant Staphylococcus aureus H.C. 20794 isolate after 20 hrs by twofold serial dilution technique2009European journal of medicinal chemistry, May, Volume: 44, Issue:5
Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.
AID420051Antimicrobial activity against Mycobacterium smegmatis UFPEDA 71 at 300 ug/disk after 24 hrs by disk diffusion method2009European journal of medicinal chemistry, May, Volume: 44, Issue:5
Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.
AID420226Antimicrobial activity against multidrug-resistant Enterococcus faecalis H.C. 24708 isolate after 20 hrs by twofold serial dilution technique2009European journal of medicinal chemistry, May, Volume: 44, Issue:5
Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.
AID420219Antimicrobial activity against multidrug-resistant Staphylococcus aureus H.C. 21141 isolate after 20 hrs by twofold serial dilution technique2009European journal of medicinal chemistry, May, Volume: 44, Issue:5
Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.
AID420216Antimicrobial activity against Mycobacterium smegmatis UFPEDA 71 after 20 hrs by twofold serial dilution technique2009European journal of medicinal chemistry, May, Volume: 44, Issue:5
Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.
AID420212Antimicrobial activity against Staphylococcus aureus UFPEDA 01 after 20 hrs by twofold serial dilution technique2009European journal of medicinal chemistry, May, Volume: 44, Issue:5
Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.
AID420225Antimicrobial activity against multidrug-resistant Enterococcus faecalis H.C. 21944 isolate after 20 hrs by twofold serial dilution technique2009European journal of medicinal chemistry, May, Volume: 44, Issue:5
Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.
AID420045Antimicrobial activity against Escherichia coli UFPEDA 224 at 300 ug/disk after 24 hrs by disk diffusion method2009European journal of medicinal chemistry, May, Volume: 44, Issue:5
Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.
AID420046Antimicrobial activity against Staphylococcus aureus UFPEDA 01 at 300 ug/disk after 24 hrs by disk diffusion method2009European journal of medicinal chemistry, May, Volume: 44, Issue:5
Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.
AID420048Antimicrobial activity against Micrococcus luteus UFPEDA 06 at 300 ug/disk after 24 hrs by disk diffusion method2009European journal of medicinal chemistry, May, Volume: 44, Issue:5
Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.
AID420227Antimicrobial activity against multidrug-resistant Enterococcus faecalis H.C. 24962 isolate after 20 hrs by twofold serial dilution technique2009European journal of medicinal chemistry, May, Volume: 44, Issue:5
Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.
AID420044Antimicrobial activity against Serratia marcescens UFPEDA 398 at 300 ug/disk after 24 hrs by disk diffusion method2009European journal of medicinal chemistry, May, Volume: 44, Issue:5
Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.
AID420218Antimicrobial activity against multidrug-resistant Staphylococcus aureus H.C. 20981 isolate after 20 hrs by twofold serial dilution technique2009European journal of medicinal chemistry, May, Volume: 44, Issue:5
Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.
AID420217Antimicrobial activity against Candida albicans UFPEDA 1007 after 48 hrs by twofold serial dilution technique2009European journal of medicinal chemistry, May, Volume: 44, Issue:5
Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.
AID420047Antimicrobial activity against Bacillus subtilis UFPEDA 16 at 300 ug/disk after 24 hrs by disk diffusion method2009European journal of medicinal chemistry, May, Volume: 44, Issue:5
Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.
AID420213Antimicrobial activity against Bacillus subtilis UFPEDA 16 after 20 hrs by twofold serial dilution technique2009European journal of medicinal chemistry, May, Volume: 44, Issue:5
Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.
AID420228Antimicrobial activity against coagulase-negative Staphylococcus H.A.M. 278 isolate after 20 hrs by twofold serial dilution technique2009European journal of medicinal chemistry, May, Volume: 44, Issue:5
Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.
AID420052Antimicrobial activity against Candida albicans UFPEDA 1007 at 300 ug/disk after 48 hrs by disk diffusion method2009European journal of medicinal chemistry, May, Volume: 44, Issue:5
Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.
AID420229Antimicrobial activity against coagulase-negative Staphylococcus H.A.M. 338 isolate after 20 hrs by twofold serial dilution technique2009European journal of medicinal chemistry, May, Volume: 44, Issue:5
Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.
AID420224Antimicrobial activity against multidrug-resistant Enterococcus faecalis H.C. 21752 isolate after 20 hrs by twofold serial dilution technique2009European journal of medicinal chemistry, May, Volume: 44, Issue:5
Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.
AID420214Antimicrobial activity against Micrococcus luteus UFPEDA 06 after 20 hrs by twofold serial dilution technique2009European journal of medicinal chemistry, May, Volume: 44, Issue:5
Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.
AID420215Antimicrobial activity against Enterococcus faecalis UFPEDA 138 after 20 hrs by twofold serial dilution technique2009European journal of medicinal chemistry, May, Volume: 44, Issue:5
Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.
AID420223Antimicrobial activity against multidrug-resistant Staphylococcus aureus H.C. 20905 isolate after 20 hrs by twofold serial dilution technique2009European journal of medicinal chemistry, May, Volume: 44, Issue:5
Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.
AID420220Antimicrobial activity against multidrug-resistant Staphylococcus aureus H.C. 21036 isolate after 20 hrs by twofold serial dilution technique2009European journal of medicinal chemistry, May, Volume: 44, Issue:5
Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.
AID420050Antimicrobial activity against Pseudomonas aeruginosa UFPEDA 39 at 300 ug/disk after 24 hrs by disk diffusion method2009European journal of medicinal chemistry, May, Volume: 44, Issue:5
Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.
AID420049Antimicrobial activity against Enterococcus faecalis UFPEDA 138 at 300 ug/disk after 24 hrs by disk diffusion method2009European journal of medicinal chemistry, May, Volume: 44, Issue:5
Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's1 (20.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.87

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.87 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.87)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ketoconazole
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.		2.0510dichlorobenzene;
dioxolane;
ether;
imidazoles;
N-acylpiperazine;
N-arylpiperazine
2,4-thiazolidinedione
thiazolidine-2,4-dione: structure in first source. 1,3-thiazolidine-2,4-dione : A thiazolidenedione carrying oxo substituents at positions 2 and 4.		2.0510thiazolidenedione
vincristine
[no description available]		2.0510acetate ester;
formamides;
methyl ester;
organic heteropentacyclic compound;
organic heterotetracyclic compound;
tertiary alcohol;
tertiary amino compound;
vinca alkaloid		antineoplastic agent;
drug;
microtubule-destabilising agent;
plant metabolite;
tubulin modulator
kanamycin a
Kanamycin: Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.. kanamycin : Kanamycin is a naturally occurring antibiotic complex from Streptomyces kanamyceticus that consists of several components: kanamycin A, the major component (also usually designated as kanamycin), and kanamycins B, C, D and X the minor components.		2.0510kanamycinsbacterial metabolite
ampicillin
Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.		2.0510beta-lactam antibiotic;
penicillin allergen;
penicillin		antibacterial drug
thiazoles
[no description available]		2.98401,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
cephalexin
Cephalexin: A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of CEPHALORIDINE or CEPHALOTHIN, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms.. cephalexin : A semisynthetic first-generation cephalosporin antibiotic having methyl and beta-(2R)-2-amino-2-phenylacetamido groups at the 3- and 7- of the cephem skeleton, respectively. It is effective against both Gram-negative and Gram-positive organisms, and is used for treatment of infections of the skin, respiratory tract and urinary tract.		2.0510beta-lactam antibiotic allergen;
cephalosporin;
semisynthetic derivative		antibacterial drug
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		2.08101,2,3-triazole
ConditionIndicatedRelationship StrengthStudiesTrials