Chronic Wasting Disease

A transmissible spongiform encephalopathy (prion disease) of DEER and elk characterized by chronic weight loss leading to death. It is thought to spread by direct contact between animals or through environmental contamination with the prion protein (PRIONS).

Synonym
Wasting Disease, Chronic
Chronic Wasting Disease

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	5 (14.29)	18.1394
2010's	25 (71.43)	28.8240
2020's	5 (14.29)	9.53

Drug	Relationship Strength	Studies
quinacrine	low	1
formic acid	low	1
formaldehyde	low	1
melatonin	low	1
2-aminothiazole	low	1
ether	low	1
serine	low	1
leucine	low	1
methionine	low	2
phenylalanine	low	1
thiazoles	low	2
thioflavin t	low	1
manganese	low	1
molybdenum	low	1
gold	low	1
transferrin	low	1
fenoxaprop ethyl	low	3
triazoles	low	1
pica	low	1
phenylephrine hydrochloride	low	1
selenium	low	1
beta-escin	low	1
tannins	low	1
oligonucleotides	low	1
cellulose	low	1
phosphatidylcholines	low	1
sodium hypochlorite	low	1
piperidines	low	1
tetracycline	low	1
clay	low	3
eye	low	1
leptin	low	1

Protein Targets (331)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
RAR-related orphan receptor gamma	3	0	0	3
GLS protein	1	0	0	1
GLI family zinc finger 3	4	0	0	4
aldehyde dehydrogenase 1 family, member A1	3	0	0	3
thyroid stimulating hormone receptor	1	0	0	1
estrogen nuclear receptor alpha	6	0	0	6
Cellular tumor antigen p53	3	0	0	3
Nitric oxide synthase, brain	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Luciferase	2	0	0	2
AR protein	4	0	0	4
estrogen receptor 2 (ER beta)	1	0	0	1
nuclear receptor subfamily 1, group I, member 3	3	0	0	3
progesterone receptor	2	0	0	2
retinoic acid nuclear receptor alpha variant 1	2	0	0	2
retinoid X nuclear receptor alpha	2	0	0	2
pregnane X nuclear receptor	3	0	0	3
peroxisome proliferator-activated receptor delta	1	0	0	1
peroxisome proliferator activated receptor gamma	3	0	0	3
aryl hydrocarbon receptor	2	0	0	2
thyroid hormone receptor beta isoform a	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	4	0	0	4
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	2	0	2
Large neutral amino acids transporter small subunit 1	0	3	0	4
Proton-coupled amino acid transporter 1	0	2	0	3
Phospholipase A-2-activating protein	0	2	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
interleukin 8	1	0	0	1
thioredoxin reductase	4	0	0	4
ClpP	1	0	0	1
phosphopantetheinyl transferase	2	0	0	2
ATAD5 protein, partial	2	0	0	2
caspase 7, apoptosis-related cysteine protease	1	0	0	1
regulator of G-protein signaling 4	2	0	0	2
EWS/FLI fusion protein	2	0	0	2
caspase-3	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	4	0	0	4
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	1	0	0	1
Bloom syndrome protein isoform 1	2	0	0	2
cytochrome P450 2D6 isoform 1	1	0	0	1
peripheral myelin protein 22 isoform 1	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
chromobox protein homolog 1	4	0	0	4
ras-related protein Rab-9A	2	0	0	2
geminin	3	0	0	3
cytochrome P450 3A4 isoform 1	1	0	0	1
M-phase phosphoprotein 8	2	0	0	2
muscarinic acetylcholine receptor M1	2	0	0	2
lamin isoform A-delta10	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	1	0	0	1
ATP-binding cassette sub-family C member 3	0	3	0	3
Multidrug resistance-associated protein 4	0	3	0	3
Bile salt export pump	0	4	0	4
Cytochrome P450 1A1	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Myeloperoxidase	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Cholinesterase	0	2	0	2
Cytochrome P450 2C11	0	1	0	1
Cytochrome P450 2D6	0	1	0	1
Aromatase	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	1	0	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	1	0	0	1
Acetylcholinesterase	0	2	0	2
Metabotropic glutamate receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	1	0	0	1
Acetylcholinesterase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	1	0	0	1
Mu-type opioid receptor	0	1	0	1
Nociceptin receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	2	0	2
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear receptor ROR-gamma	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-2	1	0	0	1
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Cytochrome P450 1B1	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
GABA theta subunit	1	0	0	1
Canalicular multispecific organic anion transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	1	0	0	1
Carboxylic ester hydrolase	0	1	0	1
Histamine H3 receptor	0	1	0	1
ATP-dependent phosphofructokinase	1	0	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
glucocorticoid receptor [Homo sapiens]	3	0	0	3
peripheral myelin protein 22	2	0	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Carbonic anhydrase 12	0	0	0	1
Carbonic anhydrase 1	0	0	0	1
Carbonic anhydrase 2	0	0	0	1
Plasma kallikrein	0	0	0	1
Carbonic anhydrase 3	0	0	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 6	0	0	0	1
Adenosine receptor A1	0	0	0	1
Adenosine receptor A2a	0	0	0	1
Carbonic anhydrase 5A, mitochondrial	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 7	0	0	0	1
Carbonic anhydrase	0	0	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2B	0	0	0	1
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
SLC16A10 protein	0	0	0	1
Carbonic anhydrase 9	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
Carbonic anhydrase 15	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
Carbonic anhydrase 14	0	0	0	1
Carbonic anhydrase 5B, mitochondrial	0	0	0	1
glp-1 receptor, partial	1	0	0	1
GALC protein	1	0	0	1
TDP1 protein	3	0	0	3
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
estrogen-related nuclear receptor alpha	2	0	0	2
IDH1	2	0	0	2
thyroid stimulating hormone receptor	1	0	0	1
beta-2 adrenergic receptor	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Spike glycoprotein	1	0	0	1
N	0	1	0	1
dopamine D1 receptor	1	0	0	1
Fumarate hydratase	1	0	0	1
USP1 protein, partial	1	0	0	1
NPYLR7B	0	0	1	1
polyprotein	1	0	0	1
67.9K protein	2	0	0	2
arylsulfatase A	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
flap endonuclease 1	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
tumor susceptibility gene 101 protein	1	0	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
DNA polymerase kappa isoform 1	2	0	0	2
histone acetyltransferase KAT2A isoform 1	1	0	0	1
Glutathione reductase, mitochondrial	0	1	0	1
Riboflavin-binding protein	0	1	1	2
Major prion protein	0	0	1	1
Major prion protein	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	3	0	3
Muscarinic acetylcholine receptor M4	0	2	0	2
ATP-dependent translocase ABCB1	0	0	1	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
DNA-directed RNA polymerase subunit alpha	0	1	0	1
DNA-directed RNA polymerase subunit omega	0	1	0	1
DNA-directed RNA polymerase subunit beta'	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Phospholipase A2, membrane associated	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Acidic phospholipase A2 2	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Sodium-dependent noradrenaline transporter	0	2	0	2
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
Trypanothione reductase	0	2	0	2
D(3) dopamine receptor	0	2	0	2
D(1A) dopamine receptor	1	0	0	1
Aldehyde oxidase 1	0	1	0	1
Cholinesterase	0	2	0	2
Aldehyde oxidase	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
Ataxin-2	1	0	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
lethal factor (plasmid)	1	0	0	1
Acetylcholinesterase	0	1	0	1
Pyruvate kinase PKM	0	0	1	1
Neutral amino acid transporter A	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	2	0	0	2
cytochrome P450 2D6	2	0	0	2
Myc proto-oncogene protein	0	1	0	1
CPG DNA methylase	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	1	2
Dual specificity mitogen-activated protein kinase kinase 3	0	1	0	1
Protein arginine N-methyltransferase 1	0	1	0	1
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
Histone-lysine N-methyltransferase EHMT1	0	1	0	1
DNA (cytosine-5)-methyltransferase 3B	0	1	0	1
DNA (cytosine-5)-methyltransferase 3-like	0	1	0	1
DNA (cytosine-5)-methyltransferase 3A	0	1	1	2
mitogen-activated protein kinase 1	1	0	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
Histone H2A.x	1	0	0	1
estrogen receptor beta isoform 1	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
Stromelysin-1	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Neutrophil collagenase	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-synuclein	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Integrase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Amyloid-beta precursor protein	0	1	0	1
Chain A, Ferritin light chain	1	0	0	1
acid sphingomyelinase	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Research

Studies (35)

Protein Targets (331)

Chronic Wasting Disease

Synonyms(2)

Research Excerpts

Research

Studies (35)

Drugs Studied (41)

Protein Targets (331)