Page last updated: 2024-08-24

triazoles and ici 195739

triazoles has been researched along with ici 195739 in 48 studies

Research

Studies (48)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (10.42)	18.7374
1990's	37 (77.08)	18.2507
2000's	6 (12.50)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Aguirre, T; Lazardi, K; Piras, MM; Piras, R; Urbina, JA	1
de Souza, W; Lazardi, K; Urbina, JA	1
Ryley, JF; Ryley, NG	1
McCormack, JG; Seow, WK; Thong, YH; Vuddhakul, V	1
Brummer, E; Hanson, LH; Stevens, DA; Tucker, RM	1
Barrett-Bee, K; Campbell, J; Lees, J; Newboult, L; Pinder, P	1
Boyle, FT; Gilman, DJ; Gravestock, MB; Wardleworth, JM	1
McGregor, S; Ryley, JF; Wilson, RG	1
Denning, DW; Hall, L; Hollis, S; Jackson, M	1
Coffmann, S; Messer, SA; Pfaller, MA	1
Anaissie, EJ; Dignani, MC; Hachem, R; Karyotakis, NC	1
Denning, DW; Law, D; Mason, C; Moore, CB; Wardle, HM	1
Graybill, JR; Holmberg, JD; Luther, MF; Najvar, LK	1
Clemons, KV; Stevens, DA	2
Bale, MJ; Buschelman, B; Pfaller, MA; Rhomberg, P	1
Barchiesi, F; Colombo, AL; Fothergill, AW; McGough, DA; Rinaldi, MG	1
Atkinson, BA; Bocanegra, R; Colombo, AL; Graybill, JR	1
Denning, DW; Law, D; Moore, CB	1
Galgiani, JN; Peng, T	1
Mochizuki, H; Murakami, K; Ohashi, M; Tsuda, T; Watanabe, T; Yamada, H	1
Maldonado, RA; Molina, J; Payares, G; Urbina, JA	1
Clemons, KV; Hanson, LH; Stevens, DA	1
Lazardi, K; Liendo, A; Molina, J; Payares, G; Perez, N; Piras, MM; Piras, R; Ryley, JF; Sanoja, C; Urbina, JA; Wincker, P	1
Denning, DW; Kelly, SL; Manning, NJ; Venkateswarlu, K	1
Kierszenbaum, F	1
Dagger, F; Hernandez, A; Liendo, A; Rangel, H; Urbina, JA	1
Cartledge, JD; Clumeck, N; De Wit, S; Denning, DW; Dupont, B; Gazzard, BG; Hawkins, DA	1
Hollis, RJ; Pfaller, MA; Zhang, J	1
Cutright, JL; Fidel, PL; Sobel, JD	1
Denning, DW; Kelly, SL; Venkateswarlu, K	1
Urbina, JA	2
Kato, K; Mochizuki, H; Watanabe, T; Yamada, H	1
Cartledge, JD; Clumeck, N; De Wit, S; Denning, DW; Dupont, B; Gazzard, BG; Hawkins, DA; Midgley, J	1
Lazardi, K; Liendo, A; Urbina, JA	1
Clumeck, AN; De Wit, S; Edwards, J; O'Doherty, E; Smith, RP; Yates, R	1
Hitchcock, CA; Koltin, Y	1
Aoki, FH; Branchini, ML; Mikami, Y; Miyaji, M; Nishimura, K; Taguchi, H; Yamamoto, K; Yang, HC; Yazawa, K	1
Atkinson, G; Denning, DW; Hollis, S; Hood, SV; Percy, M; Williams, K	1
Back, DJ; Evans, JA; McCormick, AD; McKillop, D; Tjia, J	1
Aldridge, A; Duffy, PA; Harada, T; Inokuma, M; Matsunaga, T; Mitsui, T; Shibutani, Y	1
Kikuchi, M; Kojima, M; Mikami, Y; Mochizuki, H; Nakamura, S; Nakanishii, T; Takahashi, Y; Yamada, H	1
Aldridge, A; Duffy, PA; Harada, T; Matsunaga, T; Mitsui, T; Murano, H; Shibutani, Y	1
Harada, T; Hirata, Z; Matsunaga, T; Mitsui, T; Murano, H; Shibutani, Y	1
Brener, Z; Molina, J; Romanha, AJ; Urbina, JA	1
Brener, Z; Gref, R; Molina, J; Urbina, J	1
Denning, DW; Williams, KJ	1

Reviews

4 review(s) available for triazoles and ici 195739

Article	Year
Can a killer be arrested? Nature medicine, 1996, Volume: 2, Issue:10 Topics: Animals; Chagas Disease; Humans; Insect Vectors; Mice; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	1996
Lipid biosynthesis pathways as chemotherapeutic targets in kinetoplastid parasites. Parasitology, 1997, Volume: 114 Suppl Topics: Animals; Antiprotozoal Agents; Cytochrome P-450 Enzyme Inhibitors; Drug Design; Kinetoplastida; Lipids; Methyltransferases; Oxidoreductases; Parasites; Phospholipids; Sterol 14-Demethylase; Sterols; Triazoles	1997
The search for new triazole antifungal agents. Current opinion in chemical biology, 1997, Volume: 1, Issue:2 Topics: Antifungal Agents; Drugs, Investigational; Humans; Pyrimidines; Triazoles; Voriconazole	1997
Specific treatment of Chagas disease: current status and new developments. Current opinion in infectious diseases, 2001, Volume: 14, Issue:6 Topics: Chagas Disease; Cysteine Proteinase Inhibitors; Humans; Quinazolines; Triazoles	2001

Trials

4 trial(s) available for triazoles and ici 195739

Article	Year
A dose comparison study of a new triazole antifungal (D0870) in HIV-positive patients with oral candidiasis. AIDS (London, England), 1997, Volume: 11, Issue:6 Topics: Adolescent; Adult; AIDS-Related Opportunistic Infections; Antifungal Agents; Candida; Candida albicans; Candidiasis; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Mouth Diseases; Recurrence; Treatment Outcome; Triazoles	1997
Treatment of HIV-related fluconazole-resistant oral candidosis with D0870, a new triazole antifungal. AIDS (London, England), 1998, Mar-05, Volume: 12, Issue:4 Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Candida; Candida albicans; Candidiasis, Oral; Drug Resistance, Microbial; Fluconazole; Humans; Male; Microbial Sensitivity Tests; Pilot Projects; Treatment Outcome; Triazoles	1998
Pharmacokinetics of two multiple-dosing regimens of D0870 in human immunodeficiency virus-positive patients: a phase I study. Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:4 Topics: Adolescent; Adult; Antifungal Agents; Area Under Curve; Half-Life; HIV Seropositivity; Humans; Male; Middle Aged; Triazoles	1998
Assessment of therapeutic response of oropharyngeal and esophageal candidiasis in AIDS with use of a new clinical scoring system: studies with D0870. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1999, Volume: 28, Issue:3 Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Candida albicans; Candidiasis, Oral; Colony Count, Microbial; Drug Resistance, Microbial; Esophageal Diseases; Fluconazole; Humans; Microbial Sensitivity Tests; Prospective Studies; Treatment Outcome; Triazoles	1999

Other Studies

40 other study(ies) available for triazoles and ici 195739

Article	Year
Antiproliferative effects and mechanism of action of ICI 195,739, a novel bis-triazole derivative, on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi. Antimicrobial agents and chemotherapy, 1991, Volume: 35, Issue:4 Topics: Animals; Cell Division; Chromatography, Gas; Chromatography, Thin Layer; Ergosterol; Naphthalenes; Terbinafine; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells	1991
Ultrastructural alterations induced by ICI 195,739, a bis-triazole derivative with strong antiproliferative action against Trypanosoma (Schizotrypanum) cruzi. Antimicrobial agents and chemotherapy, 1991, Volume: 35, Issue:4 Topics: Animals; Ergosterol; Ketoconazole; Naphthalenes; Terbinafine; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells	1991
Candida albicans--do mycelia matter? Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology, 1990, Volume: 28, Issue:3 Topics: Amphotericin B; Animals; Candida albicans; Candidiasis; Culture Media; Kidney Cortex; Kidney Diseases; Kidney Glomerulus; Mice; Triazoles	1990
Effects of the newer antifungal agents (bifonazole, ICI 195, 739 and amorolfin) on in vitro phagocytic, lymphocytic and natural-killer cell responses. International journal of immunopharmacology, 1989, Volume: 11, Issue:7 Topics: Antifungal Agents; Humans; Imidazoles; In Vitro Techniques; Killer Cells, Natural; Lymphocyte Activation; Lymphocytes; Morpholines; Neutrophils; Phagocytosis; Triazoles	1989
Activity of ICI 195,739, a new oral triazole, compared with that of ketoconazole in the therapy of experimental murine blastomycosis. Antimicrobial agents and chemotherapy, 1989, Volume: 33, Issue:4 Topics: Animals; Antifungal Agents; Blastomyces; Blastomycosis; Ketoconazole; Male; Mice; Mice, Inbred BALB C; Time Factors; Triazoles	1989
Biochemical studies with a novel antifungal agent, ICI 195,739. Annals of the New York Academy of Sciences, 1988, Volume: 544 Topics: Animals; Antifungal Agents; Aromatase; Candida albicans; Cytochrome P-450 Enzyme System; Female; Humans; Kinetics; Lanosterol; Male; Placenta; Pregnancy; Rats; Steroids; Sterols; Testosterone; Triazoles	1988
Synthesis and structure-activity relationships of a novel antifungal agent, ICI 195,739. Annals of the New York Academy of Sciences, 1988, Volume: 544 Topics: Animals; Antifungal Agents; Candida albicans; Candidiasis, Vulvovaginal; Female; Mice; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship; Triazoles	1988
Activity of ICI 195,739--a novel, orally active bistriazole--in rodent models of fungal and protozoal infections. Annals of the New York Academy of Sciences, 1988, Volume: 544 Topics: Animals; Antifungal Agents; Antiprotozoal Agents; Candidiasis, Vulvovaginal; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Malaria; Mice; Rats; Structure-Activity Relationship; Tinea; Triazoles; Trypanosomiasis	1988
Efficacy of D0870 compared with those of itraconazole and amphotericin B in two murine models of invasive aspergillosis. Antimicrobial agents and chemotherapy, 1995, Volume: 39, Issue:8 Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Colony Count, Microbial; Female; Immunosuppression Therapy; Itraconazole; Leukocyte Count; Lung Diseases, Fungal; Mice; Mice, Inbred Strains; Microbial Sensitivity Tests; Neutrophils; Triazoles	1995
Comparison of visual and spectrophotometric methods of MIC endpoint determinations by using broth microdilution methods to test five antifungal agents, including the new triazole D0870. Journal of clinical microbiology, 1995, Volume: 33, Issue:5 Topics: Antifungal Agents; Candida; Candida albicans; Evaluation Studies as Topic; Humans; Microbial Sensitivity Tests; Reference Standards; Spectrophotometry; Triazoles	1995
Activities of D0870, a novel triazole, against Candida lusitaniae and Trichosporon beigelii in experimental murine infections. Antimicrobial agents and chemotherapy, 1995, Volume: 39, Issue:2 Topics: Animals; Antifungal Agents; Candida; Candidiasis; Male; Mice; Microbial Sensitivity Tests; Mycoses; Triazoles; Trichosporon	1995
In vitro activity of D0870 compared with those of other azoles against fluconazole-resistant Candida spp. Antimicrobial agents and chemotherapy, 1995, Volume: 39, Issue:4 Topics: Antifungal Agents; Candida; Drug Resistance, Microbial; Fluconazole; Itraconazole; Ketoconazole; Microbial Sensitivity Tests; Triazoles	1995
Fluconazole, D0870, and flucytosine treatment of disseminated Candida tropicalis infections in mice. Antimicrobial agents and chemotherapy, 1995, Volume: 39, Issue:4 Topics: Animals; Antifungal Agents; Candidiasis; Drug Therapy, Combination; Fluconazole; Flucytosine; Mice; Mice, Inbred ICR; Triazoles	1995
Efficacy of the triazole D0870 in a murine model of systemic histoplasmosis. Antimicrobial agents and chemotherapy, 1995, Volume: 39, Issue:3 Topics: Animals; Antifungal Agents; Female; Fluconazole; Histoplasmosis; Liver; Mice; Spleen; Triazoles	1995
Antifungal activity of a new triazole, D0870, compared with four other antifungal agents tested against clinical isolates of Candida and Torulopsis glabrata. Diagnostic microbiology and infectious disease, 1994, Volume: 19, Issue:2 Topics: Antifungal Agents; Candida; Fluconazole; Itraconazole; Microbial Sensitivity Tests; Triazoles	1994
In vitro activity of a new antifungal triazole, D0870, against Candida albicans isolates from oral cavities of patients infected with human immunodeficiency virus. Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:11 Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Candida albicans; Candidiasis, Oral; Drug Resistance, Microbial; Humans; Microbial Sensitivity Tests; Stereoisomerism; Triazoles	1994
Treatment of disseminated Torulopsis glabrata infection with DO870 and amphotericin B. Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:7 Topics: Amphotericin B; Animals; Antifungal Agents; Candidiasis; Drug Synergism; Drug Therapy, Combination; Fluconazole; Immunosuppression Therapy; Kidney; Male; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Spleen; Triazoles	1994
Utility of the triazole D0870 in the treatment of experimental systemic coccidioidomycosis. Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology, 1994, Volume: 32, Issue:4 Topics: Animals; Antifungal Agents; Coccidioides; Coccidioidomycosis; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fluconazole; Liver; Lung; Mice; Mice, Inbred Strains; Spleen; Stereoisomerism; Triazoles	1994
In-vitro activity of the new triazole D0870 compared with amphotericin B and itraconazole against Aspergillus spp. The Journal of antimicrobial chemotherapy, 1993, Volume: 32, Issue:6 Topics: Amphotericin B; Antifungal Agents; Aspergillus; Aspergillus flavus; Aspergillus fumigatus; Aspergillus niger; Itraconazole; Microbial Sensitivity Tests; Reproducibility of Results; Stereoisomerism; Triazoles	1993
In vitro studies of a new antifungal triazole, D0870, against Candida albicans, Cryptococcus neoformans, and other pathogenic yeasts. Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:10 Topics: Antifungal Agents; Candida albicans; Cryptococcus neoformans; Hydrogen-Ion Concentration; Microbial Sensitivity Tests; Temperature; Triazoles	1993
In vitro and in vivo antifungal activities of D0870, a new triazole agent. Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:11 Topics: Animals; Antifungal Agents; Culture Media; Fungi; Hydrogen-Ion Concentration; Immunosuppression Therapy; Male; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Mycoses; Stereoisomerism; Triazoles	1993
Experimental chemotherapy with combinations of ergosterol biosynthesis inhibitors in murine models of Chagas' disease. Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:6 Topics: Animals; Antifungal Agents; Chagas Disease; Disease Models, Animal; Ergosterol; Female; Ketoconazole; Mice; Naphthalenes; Terbinafine; Triazoles; Trypanocidal Agents	1993
Activities of the triazole D0870 in vitro and against murine blastomycosis. Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:5 Topics: Animals; Antifungal Agents; Blastomyces; Blastomycosis; Fluconazole; Male; Mice; Microbial Sensitivity Tests; Triazoles	1993
Cure of short- and long-term experimental Chagas' disease using D0870. Science (New York, N.Y.), 1996, Aug-16, Volume: 273, Issue:5277 Topics: Animals; Base Sequence; Chagas Disease; Drug Administration Schedule; Ketoconazole; Molecular Sequence Data; Nifurtimox; Sterols; Time Factors; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	1996
Comparison of D0870, a new triazole antifungal agent, to fluconazole for inhibition of Candida albicans cytochrome P-450 by using in vitro assays. Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:6 Topics: Antifungal Agents; Candida albicans; Cytochrome P-450 Enzyme System; Ergosterol; Fluconazole; Gas Chromatography-Mass Spectrometry; Humans; Microbial Sensitivity Tests; Microsomes; Structure-Activity Relationship; Triazoles	1996
Naturally azole-resistant Leishmania braziliensis promastigotes are rendered susceptible in the presence of terbinafine: comparative study with azole-susceptible Leishmania mexicana promastigotes. Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:12 Topics: Animals; Antifungal Agents; Azoles; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Drug Resistance; Enzyme Inhibitors; Ketoconazole; Leishmania braziliensis; Leishmania mexicana; Naphthalenes; Oxidoreductases; Squalene; Sterol 14-Demethylase; Sterols; Terbinafine; Triazoles	1996
Variations in DNA subtype and antifungal susceptibility among clinical isolates of Candida tropicalis. Diagnostic microbiology and infectious disease, 1997, Volume: 27, Issue:3 Topics: Amphotericin B; Antifungal Agents; Candida; Candidiasis; Cross Infection; DNA, Fungal; Electrophoresis, Gel, Pulsed-Field; Fluconazole; Flucytosine; Humans; Itraconazole; Microbial Sensitivity Tests; Mycological Typing Techniques; Polymorphism, Restriction Fragment Length; Triazoles	1997
Efficacy of D0870 treatment of experimental Candida vaginitis. Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:7 Topics: Animals; Antifungal Agents; Candidiasis; Drug Resistance, Microbial; Female; Fluconazole; Mice; Mice, Inbred CBA; Microbial Sensitivity Tests; Triazoles; Vaginitis	1997
In-vitro activity of D0870, a new triazole antifungal drug, in comparison with fluconazole and itraconazole against Aspergillus fumigatus and Candida krusei. The Journal of antimicrobial chemotherapy, 1997, Volume: 39, Issue:6 Topics: Antifungal Agents; Aspergillus fumigatus; Candida; Carbon Monoxide; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Ergosterol; Fluconazole; Itraconazole; Time Factors; Triazoles	1997
Fungicidal mechanism of action of D0870 against Cryptococcus neoformans under acidic conditions. Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:12 Topics: Antifungal Agents; Cryptococcus neoformans; Hydrogen-Ion Concentration; Microbial Sensitivity Tests; Potassium; Sterols; Triazoles	1997
In-vitro antiproliferative effects and mechanism of action of the bis-triazole D0870 and its S(-) enantiomer against Trypanosoma cruzi. The Journal of antimicrobial chemotherapy, 1998, Volume: 41, Issue:2 Topics: Animals; Cell Division; Chlorocebus aethiops; Dose-Response Relationship, Drug; Sterols; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells	1998
Colorimetric MTT assessment of antifungal activity of D0870 against fluconazole-resistant Candida albicans. Mycoses, 1998, Volume: 41, Issue:11-12 Topics: Antifungal Agents; Candida albicans; Candidiasis; Colorimetry; Drug Resistance, Microbial; Fluconazole; Humans; Microbial Sensitivity Tests; Tetrazolium Salts; Thiazoles; Triazoles	1998
Preclinical and in vitro assessment of the potential of D0870, an antifungal agent, for producing clinical drug interactions. Xenobiotica; the fate of foreign compounds in biological systems, 1999, Volume: 29, Issue:4 Topics: Animals; Antifungal Agents; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Hypnotics and Sedatives; Inhibitory Concentration 50; Kinetics; Male; Microsomes, Liver; Models, Chemical; Pentobarbital; Rats; Time Factors; Triazoles	1999
QT prolongation and torsades de pointes induced by an antifungal agent, D0870, in conscious dogs. Toxicology, 1999, Feb-15, Volume: 132, Issue:2-3 Topics: Animals; Antifungal Agents; Dogs; Electrocardiography; Female; Male; Torsades de Pointes; Triazoles	1999
Antifungal activities of D0870 against fluconazole-resistant Candida albicans. Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology, 1999, Volume: 40, Issue:4 Topics: Animals; Antifungal Agents; Candida albicans; Drug Resistance, Microbial; Fluconazole; Male; Mice; Mice, Inbred ICR; Triazoles	1999
Influences of catecholamines on the sudden death induced in dogs by an antifungal agent, D0870. Journal of electrocardiology, 2000, Volume: 33, Issue:2 Topics: Action Potentials; Animals; Antifungal Agents; Catecholamines; Death, Sudden, Cardiac; Dogs; Electrocardiography; Epinephrine; Heart Ventricles; Isoproterenol; Torsades de Pointes; Triazoles	2000
D0870, an antifungal agent, induces reverse use-dependent QT prolongation in dogs. The Journal of veterinary medical science, 2000, Volume: 62, Issue:5 Topics: Action Potentials; Animals; Antifungal Agents; Dogs; Electric Stimulation; Electrocardiography, Ambulatory; Female; Male; Purkinje Fibers; Torsades de Pointes; Triazoles	2000
In vivo activity of the bis-triazole D0870 against drug-susceptible and drug-resistant strains of the protozoan parasite Trypanosoma cruzi. The Journal of antimicrobial chemotherapy, 2000, Volume: 46, Issue:1 Topics: Animals; Chagas Disease; Drug Resistance; Female; Mice; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2000
Cure of experimental Chagas' disease by the bis-triazole DO870 incorporated into 'stealth' polyethyleneglycol-polylactide nanospheres. The Journal of antimicrobial chemotherapy, 2001, Volume: 47, Issue:1 Topics: Animals; Chagas Disease; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Female; Mice; Microspheres; Polyesters; Polyethylene Glycols; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2001
Termination of development of D0870. The Journal of antimicrobial chemotherapy, 2001, Volume: 47, Issue:5 Topics: Animals; Antifungal Agents; Drug Design; Drug Industry; Humans; Long QT Syndrome; Triazoles	2001