Clubfeet

Synonym
Talipes Equinovarus
Clubfeet
Clubfeet, Congenital
Equinovarus
Clubfoot
Pie Torcido
Clubfoot, Congenital
Congenital Talipes Equinovarus

Excerpt	Reference
"Clubfeet are resistant to correction and warrant early orthopedic consultation."	( Yngve, DA, 1984)
"Inturning in clubfeet is associated with knee dynamics alteration, which might contribute to the long-term development of knee osteoarthritis."	( Andre, JM; Beyaert, C; Haumont, T; Lascombes, P; Paysant, J, 2003)
"Congenital clubfoot is correlated closely with defects of neural tube and spinal cord."	( Du, SX; Ji, SJ; Sun, KL, 2005)
"Clubfoot is the commonest congenital deformity in babies."	( Gupta, A; Patel, J; Patel, P; Singh, S; Varshney, MK, 2008)
"Talipes equinovarus is the most common congenital lower limb abnormality."	( Briggs, D; Fulton, Z; Silva, S; Szalay, EA, 2015)
"Idiopathic pes equinovarus is a congenital deformity of the foot and lower leg defined as a fixation of the foot in adduction, supination, and varus."	( Burian, M; Chomiak, J; Dungl, P; Eckhardt, A; Frydrychová, M; Herget, J; Mikšík, I; Ošt'ádal, M, 2015)
"Clubfoot is a congenital deformity affecting the musculoskeletal system, resulting in contracted and stiff tissue in the medial part of the foot."	( Bacakova, L; Doubkova, M; Eckhardt, A; Knitlova, J; Musilkova, J; Novotny, T; Ostadal, M; Plencner, M; Vondrasek, D, 2021)
"Congenital clubfoot is a complex musculoskeletal deformity, in which a stiff, contracted tissue forms in the medial part of the foot."	( Bacakova, L; Doubkova, M; Eckhardt, A; Knitlova, J; Musilkova, J; Novotny, T; Ostadal, M, 2021)

Excerpt	Reference
"Congenital Talipes Equinovarus often remains untreated in developing countries."	( Sengupta, A, 1987)
"Twenty-four of the 62 clubfeet were treated conservatively and 38 had at least one operative intervention."	( Berggren, L; Widhe, T, 1994)
"Experimental induction of clubfoot-like deformity in rat fetuses was produced by maternal administration of retinoic acid (120 mg/kg body weight) as a single intragastric dose on day 10 of pregnancy."	( Delgado-Baeza, E; Martos-Rodríguez, A; Santos-Alvarez, I, 1999)
"Experimental induction of clubfoot-like deformity in rat fetuses was performed by maternal administration of retinoic acid (RA) (120 mg/kg body weight) as a single intragastric dose on day 10 of pregnancy (previous phase of this assay)."	( Delgado-Baeza, E; Martos-Rodríguez, A; Santos-Alvarez, I, 2003)
"The fetal rat models with congenital clubfoot were constructed by treating 24 Wistar rats with all trans retinoic acid (ATRA)."	( Dong, LY; Guo, L; Ji, SJ; Sun, KL; Zhao, YY, 2004)
"Many patients with clubfoot treated with an extensive soft-tissue release have poor long-term foot function."	( Dobbs, MB; Nunley, R; Schoenecker, PL, 2006)
"The Ponseti method of correcting clubfoot is especially important in developing countries, where operative facilities are not available in the remote areas and well-trained physicians and personnel can manage the cases effectively with cast treatment only."	( Gupta, A; Patel, J; Patel, P; Singh, S; Varshney, MK, 2008)
"Popular initial treatment for congenital clubfoot includes the use of serial manipulations and casting as described by Ponseti et al."	( Beebe, AC; Klingele, KE; Pittner, DE, 2008)
"Conservative clubfoot treatment requires weekly cast changes."	( Cheng, JC; Lam, TP; Ng, BK, 2010)
"The percentage of clubfeet that were treated with surgery in each year was calculated by dividing the number of surgical release procedures by the number of clubfoot diagnoses."	( Ebramzadeh, E; Hitchcock, K; Maewal, J; Zhao, G; Zionts, LE, 2010)
"The Ponseti method of clubfoot treatment has been shown to be a very safe, effective and minimally invasive technique when performed in medical centers in Europe and North America."	( Aroojis, AJ; Belthur, MV; Cook, T; Gadhok, K; Morcuende, JA; Oprescu, F; Ranade, AS, 2012)
"The Ponseti method for treating congenital clubfoot requires Achilles tenotomy to be performed toward the end of serial casting."	( Beppu, M; Hirano, T; Nakajima, H; Niki, H; Okada, H, 2013)
"We studied 36 patients with congenital clubfoot who were treated with the Ponseti method and underwent Achilles tenotomy."	( Beppu, M; Hirano, T; Nakajima, H; Niki, H; Okada, H, 2013)
"Eligible children with idiopathic clubfoot, treated using the Ponseti method, were randomised to either below- or above-knee plaster of Paris casting."	( Bridgens, J; Gallacher, PD; Kiely, NT; Kuiper, JH; Maripuri, SN, 2013)
"Ponseti treatment for clubfoot is effective and inexpensive, improving children's social participation."	( Chamberlain, MA; O'Connor, RJ; Ramahenina, H, 2016)
"Idiopathic clubfoot treatment is treated by manipulation and casting utilizing the Ponseti technique which can make the infant fussy and irritable."	( Iwinski, H; Kryscio, R; Milbrandt, T; Muchow, R; Talwalkar, V; Walker, J, 2018)
"Even when clubfoot deformity is treated in a timely manner, the consequences observed in adulthood include hypoplasia of the calf muscles, gait impairment, decreases in foot size, and it can also affect the tibial length."	( Andjelkov, K; Atanasijevic, TC; Colic, M; Llull, R; Popovic, VM, 2018)
"Background and purpose - Idiopathic clubfeet are commonly treated with serial manipulation and casting, known as the Ponseti method."	( Giesberts, RB; Hekman, EEG; Maathuis, PGM; Verkerke, GJ, 2018)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	170 (56.11)	23.3326
1990's	31 (10.23)	12.5806
2000's	47 (15.51)	18.1394
2010's	41 (13.53)	28.8240
2020's	14 (4.62)	9.53

Drug	Relationship Strength	Studies	Trials
ammonium hydroxide	low	1	0
chlorine	low	2	0
salicylic acid	low	5	0
glycine	low	1	0
iodine	low	2	0
dihydroxyphenylalanine	low	1	0
nitrous oxide	low	3	0
taurine	low	1	0
urea	low	1	0
2,4,5-trichlorophenoxyacetic acid	low	1	0
aminopropionitrile	low	1	0
phenytoin	low	1	0
aspirin	low	1	0
benserazide	low	1	0
bupivacaine	medium	3	1
caffeine	low	1	0
chlorambucil	low	1	0
chlorpromazine	low	1	0
disulfiram	low	1	0
fentanyl	low	1	0
flumazenil	low	1	0
fluorouracil	low	1	0
halothane	low	3	0
hydrochlorothiazide	low	1	0
2-propanol	low	1	0
mepivacaine	low	1	0
minoxidil	low	1	0
apnea	low	1	0
pamidronate	low	2	0
procaine	low	1	0
prochlorperazine	low	1	0
propofol	low	3	0
sevoflurane	low	4	0
streptonigrin	low	1	0
thalidomide	low	2	0
thiotepa	low	1	0
estriol	low	1	0
thymidine	low	2	0
floxuridine	low	1	0
thyroxine	low	2	0
prednisone	low	1	0
idoxuridine	low	1	0
sucrose	medium	1	1
tubocurarine	low	2	0
levodopa	low	2	0
adenosine monophosphate	low	1	0
leucine	low	1	0
colchicine	low	1	0
norethindrone	low	1	0
mestranol	low	1	0
acrylonitrile	low	1	0
methohexital	low	1	0
chlormadinone acetate	low	1	0
calcium lactate	low	1	0
fluorescein	low	1	0
streptomycin	low	1	0
mercury	low	1	0
technetium	low	1	0
cadmium	low	1	0
gold	low	1	0
calcium sulfate	medium	12	3
fluorine	low	1	0
trolamine salicylate	low	16	0
iodine	low	1	0
transferrin	low	1	0
paclitaxel	low	1	0
substance p	medium	1	1
propiconazole	low	1	0
atracurium	low	1	0
fomesafen	low	4	0
remifentanil	low	1	0
cephalosporin c	low	1	0
triazoles	low	1	0
homocysteine	low	1	0
hydroxypropylmethylcellulose acetate succinate	low	1	0
aminopterin	low	1	0
atropine	low	1	0
ropivacaine	low	1	0
carboplatin	low	1	0
lithium chloride	low	1	0
glycogen	low	1	0
elastin	low	1	0
inositol 3-phosphate	low	5	0
rocuronium	low	1	0
tretinoin	low	10	0
dactinomycin	low	1	0
thiourea	low	1	0
lithium	low	1	0
dermatan sulfate	low	1	0
quinine	low	1	0
misoprostol	low	1	0
phenylephrine hydrochloride	low	6	0
morphine	low	3	0
cysteine	low	1	0
radium	low	1	0
pituitrin	low	1	0
clove	low	1	0
jaw	low	1	0
vendex	medium	3	1
sodium ethylxanthate	low	1	0
piperidines	low	1	0
methylcellulose	low	1	0
tetracycline	low	1	0
salicylates	low	1	0
transforming growth factor beta	low	2	0
ephrin-a5	low	1	0
exudates	low	3	0
acyclovir	low	1	0
folic acid	low	2	0
neopterin	low	1	0
olanzapine	low	1	0
trypan blue	low	1	0

Protein Targets (1,007)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	12	0	0	12
RAR-related orphan receptor gamma	27	0	0	27
GLI family zinc finger 3	31	0	0	31
AR protein	37	0	0	37
aldehyde dehydrogenase 1 family, member A1	20	0	0	20
retinoic acid nuclear receptor alpha variant 1	28	0	0	28
retinoid X nuclear receptor alpha	25	0	0	25
estrogen nuclear receptor alpha	45	0	0	45
peroxisome proliferator-activated receptor delta	21	0	0	21
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	17	0	0	17
activating transcription factor 6	14	0	0	14
v-jun sarcoma virus 17 oncogene homolog (avian)	22	0	0	22
Histone H2A.x	18	0	0	18
thyroid hormone receptor beta isoform a	12	0	0	12
heat shock protein beta-1	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 1	30	0	0	30
lamin isoform A-delta10	28	0	0	28
Voltage-dependent calcium channel gamma-2 subunit	15	0	0	15
Glutamate receptor 2	16	0	0	16
Chain A, Putative fructose-1,6-bisphosphate aldolase	10	0	0	10
SMAD family member 2	8	0	0	8
SMAD family member 3	8	0	0	8
estrogen-related nuclear receptor alpha	37	0	0	37
farnesoid X nuclear receptor	20	0	0	20
pregnane X nuclear receptor	31	0	0	31
peroxisome proliferator activated receptor gamma	20	0	0	20
vitamin D (1,25- dihydroxyvitamin D3) receptor	20	0	0	20
thyroid hormone receptor beta isoform 2	27	0	0	27
Androgen receptor	0	8	0	8
thyroid stimulating hormone receptor	15	0	0	15
Cellular tumor antigen p53	26	0	0	26
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	10	0	0	10
Chain B, HADH2 protein	10	0	0	10
Chain A, ATP-DEPENDENT DNA HELICASE Q1	6	0	0	6
Chain A, Ferritin light chain	11	0	0	11
Thymidine kinase	0	3	0	4
thioredoxin reductase	20	0	0	20
phosphopantetheinyl transferase	14	0	0	14
GLS protein	14	0	0	14
TDP1 protein	31	0	0	31
Smad3	6	0	0	6
EWS/FLI fusion protein	13	0	0	13
arylsulfatase A	13	0	0	13
euchromatic histone-lysine N-methyltransferase 2	35	0	0	35
Bloom syndrome protein isoform 1	17	0	0	17
hemoglobin subunit beta	3	0	0	3
atrial natriuretic peptide receptor 1 precursor	5	0	0	5
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
Solute carrier family 22 member 1	0	7	0	8
ATP-binding cassette sub-family C member 3	0	22	0	22
Multidrug resistance-associated protein 4	0	22	0	23
Solute carrier family 22 member 6	0	3	0	4
Bile salt export pump	0	5	0	5
Bile salt export pump	0	32	0	32
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	3	0	6
POU domain, class 2, transcription factor 2	0	0	0	1
Cytochrome P450 2C9	0	5	1	6
Cytochrome P450 2J2	0	3	0	3
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	1	0	2
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	3
Canalicular multispecific organic anion transporter 1	0	22	0	22
Thymidine kinase	0	1	0	2
Chain A, Glycogen Phosphorylase B	0	0	1	1
Chain B, Glycogen Phosphorylase B	0	0	1	1
Chain A, ADP-dependent glucokinase	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, phosphodiesterase-nucleotide pyrophosphatase	0	1	0	1
Chain A, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
Chain B, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
Chain A, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
regulator of G-protein signaling 4	10	0	0	10
glucocorticoid receptor [Homo sapiens]	28	0	0	28
2'-deoxynucleoside 5'-phosphate N-hydrolase 1	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
2'-deoxynucleoside 5'-phosphate N-hydrolase 1	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	1	2
Transient receptor potential cation channel subfamily M member 2	0	1	0	1
Alcohol dehydrogenase E chain	0	2	0	2
Alcohol dehydrogenase S chain	0	2	0	2
L-lactate dehydrogenase A chain	0	1	1	2
Adenylate kinase isoenzyme 1	0	0	0	1
Fructose-1,6-bisphosphatase 1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	2
Fructose-1,6-bisphosphatase 1	0	2	0	2
2-dehydropantoate 2-reductase	0	1	1	2
Inosine-5'-monophosphate dehydrogenase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	2	0	2
Amine oxidase [flavin-containing] B	0	1	0	1
5'-nucleotidase	0	0	0	1
Choline O-acetyltransferase	0	1	0	1
Adenylate kinase 2, mitochondrial	0	1	0	2
GTP:AMP phosphotransferase AK3, mitochondrial	0	0	0	1
Adenosine receptor A1	0	1	2	5
Adenylate kinase isoenzyme 1	0	1	0	2
P2Y purinoceptor 2	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	2	3
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	2
Adenylate kinase 2, mitochondrial	0	0	0	1
Glycine--tRNA ligase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	2	3
Adenosine deaminase-like protein	0	0	0	1
Protease	0	1	1	2
P2Y purinoceptor 11	0	0	1	1
Histamine H3 receptor	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	1	2
5'-AMP-activated protein kinase subunit gamma-2	0	0	1	2
5'-AMP-activated protein kinase subunit beta-1	0	0	2	3
ATP-dependent phosphofructokinase	16	0	0	16
ATAD5 protein, partial	12	0	0	12
Lysyl oxidase homolog 2	0	1	0	1
Protein-lysine 6-oxidase	0	2	0	2
Protein-lysine 6-oxidase	0	1	0	1
Lysyl oxidase homolog 2	0	1	0	1
Lysyl oxidase homolog 3	0	2	0	2
Lysyl oxidase homolog 4	0	2	0	2
Lysyl oxidase homolog 2	0	2	0	2
nuclear receptor subfamily 1, group I, member 3	28	0	0	28
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	6	0	0	6
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	2
5-hydroxytryptamine receptor 2C	0	3	0	4
Dihydrofolate reductase	0	1	1	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Solute carrier organic anion transporter family member 1A3	0	2	0	3
Folylpolyglutamate synthase, mitochondrial	0	0	0	3
Microtubule-associated protein tau	13	0	0	13
D(1A) dopamine receptor	6	0	0	6
neuropeptide S receptor isoform A	6	0	0	6
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	21	0	0	21
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	10	0	0	10
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	9	0	0	9
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	5	0	0	5
hypothetical protein, conserved	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	20	0	0	20
cytochrome P450 2D6	13	0	0	13
glucocerebrosidase	5	0	0	5
Rac1 protein	0	0	1	1
IDH1	11	0	0	11
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	7	0	0	7
DNA polymerase iota isoform a (long)	11	0	0	11
DNA polymerase kappa isoform 1	14	0	0	14
muscarinic acetylcholine receptor M1	14	0	0	14
lethal factor (plasmid)	8	0	0	8
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Epidermal growth factor receptor	0	6	0	6
Carbonic anhydrase 1	0	10	0	11
Carbonic anhydrase 2	0	12	1	14
Fatty acid-binding protein, liver	0	1	0	1
Integrin beta-3	3	2	0	5
Myeloperoxidase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	3	1	0	4
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	5	0	5
Adenosine receptor A1	1	4	0	7
Adenosine receptor A2a	0	3	0	6
Substance-P receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	4	0	4
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	6	1	1	8
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	9	5	1	15
Prostaglandin G/H synthase 2	0	2	0	2
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	7	1	8
Sigma non-opioid intracellular receptor 1	0	1	1	2
NPYLR7B	0	0	1	1
Amine oxidase [flavin-containing] A	0	0	1	1
Small conductance calcium-activated potassium channel protein 3	0	1	1	2
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	5	0	0	5
short transient receptor potential channel 6 isoform 1	0	0	1	1
5-hydroxytryptamine receptor 4	0	10	0	10
Muscarinic acetylcholine receptor M2	0	8	1	12
Muscarinic acetylcholine receptor M4	0	8	1	11
Muscarinic acetylcholine receptor M1	0	4	1	7
Muscarinic acetylcholine receptor M3	0	4	1	7
Muscarinic acetylcholine receptor M4	0	4	1	7
Muscarinic acetylcholine receptor M5	0	4	1	7
Muscarinic acetylcholine receptor M5	0	8	1	11
Muscarinic acetylcholine receptor M2	0	4	1	8
Muscarinic acetylcholine receptor M1	0	7	2	12
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M3	0	8	1	11
Alpha-1D adrenergic receptor	0	8	0	8
5-hydroxytryptamine receptor 2C	0	10	0	10
Muscarinic acetylcholine receptor M4	0	1	0	1
Histamine H2 receptor	7	0	0	8
5-hydroxytryptamine receptor 7	0	5	0	5
Reverse transcriptase/RNaseH	0	1	0	2
Muscarinic acetylcholine receptor	0	1	1	3
vitamin D3 receptor isoform VDRA	16	0	0	16
chromobox protein homolog 1	17	0	0	17
serine/threonine-protein kinase mTOR isoform 1	5	0	0	5
M-phase phosphoprotein 8	6	0	0	6
Zinc finger protein mex-5	0	0	1	1
POsterior Segregation	0	0	1	1
Genome polyprotein	0	1	0	1
Replicase polyprotein 1ab	0	5	1	6
D(1A) dopamine receptor	3	0	0	3
Hexokinase-2	0	1	0	1
Potassium channel subfamily K member 3	0	3	0	3
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	2	2	4
Potassium channel subfamily K member 9	0	1	0	1
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
thyroid stimulating hormone receptor	11	0	0	11
nuclear receptor ROR-gamma isoform 1	12	0	0	12
geminin	29	0	0	29
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	1	0	1
Cholinesterase	0	1	0	1
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	4	1	5
Adenosine receptor A3	0	5	0	5
Amine oxidase [flavin-containing] A	0	3	0	3
Acetylcholinesterase	0	4	0	4
Amine oxidase [flavin-containing] B	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	3	0	3
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	2	1	4
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	2	0	3
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	2	0	2
Serine/threonine-protein kinase ATR	0	2	0	2
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	2	3
Endochitinase B1	0	1	0	1
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Guanine deaminase	0	1	0	1
acetylcholinesterase	9	0	0	9
estrogen receptor 2 (ER beta)	14	0	0	14
G	16	0	0	16
histone-lysine N-methyltransferase 2A isoform 2 precursor	5	0	0	5
histone acetyltransferase KAT2A isoform 1	12	0	0	12
Interferon beta	18	0	0	18
HLA class I histocompatibility antigen, B alpha chain	16	0	0	16
Inositol hexakisphosphate kinase 1	16	0	0	16
cytochrome P450 2C9, partial	16	0	0	16
Luciferase	16	0	0	16
NFKB1 protein, partial	5	0	0	5
GALC protein	4	0	0	4
Thrombopoietin	6	0	0	6
thioredoxin glutathione reductase	6	0	0	6
caspase 7, apoptosis-related cysteine protease	6	0	0	6
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	9	0	0	9
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
caspase-3	6	0	0	6
peripheral myelin protein 22 isoform 1	5	0	0	5
potassium voltage-gated channel subfamily H member 2 isoform d	6	0	0	6
FAD-linked sulfhydryl oxidase ALR	0	0	0	2
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
urokinase plasminogen activator surface receptor precursor	4	0	0	4
peripheral myelin protein 22	17	0	0	17
survival motor neuron protein isoform d	14	0	0	14
muscleblind-like protein 1 isoform 1	6	0	0	6
Carbonic anhydrase 12	0	3	0	4
Cytochrome P450 2D6	0	5	2	7
Spike glycoprotein	12	2	1	15
Carbonic anhydrase 9	0	4	1	6
ATPase family AAA domain-containing protein 5	9	0	0	9
Ataxin-2	11	0	0	11
Solute carrier organic anion transporter family member 1B3	0	4	0	4
Carbonic anhydrase 4	0	4	0	5
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase 15	0	3	0	4
Chain A, Cruzipain	7	0	0	7
progesterone receptor	18	0	0	18
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	9	0	0	9
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
transcriptional regulator ERG isoform 3	3	0	0	3
importin subunit beta-1 isoform 1	4	0	0	4
mitogen-activated protein kinase 1	6	0	0	6
snurportin-1	4	0	0	4
Glucocorticoid receptor	0	8	1	9
Glycine receptor subunit alpha-1	0	8	0	8
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
Cytochrome P450 2C19	0	1	1	2
Proteasome subunit beta type-11	0	0	0	1
Fumarate hydratase	3	0	0	3
USP1 protein, partial	11	0	0	11
NADPH oxidase 1	0	1	0	1
polyprotein	3	0	0	3
67.9K protein	8	0	0	8
Snq2p	0	0	0	2
Adenylate cyclase type 1	0	2	0	2
Caspase-7	5	0	0	5
Spike glycoprotein	0	2	1	3
Replicase polyprotein 1ab	0	2	1	3
cytochrome P450 2D6 isoform 1	5	0	0	5
cellular tumor antigen p53 isoform a	4	0	0	4
caspase-3	5	0	0	5
histone deacetylase 9 isoform 3	4	0	0	4
atrial natriuretic peptide receptor 2 precursor	4	0	0	4
ras-related protein Rab-9A	3	0	0	3
cytochrome P450 3A4 isoform 1	9	0	0	9
Gamma-aminobutyric acid receptor subunit pi	9	4	1	14
Proteasome subunit alpha type-7	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	4	0	0	4
Transmembrane protease serine 2	0	2	1	3
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Albumin	0	4	2	6
Albumin	0	0	1	1
Major prion protein	0	0	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Major prion protein	0	0	1	1
Cytochrome P450 1A2	0	2	2	4
Tyrosine-protein kinase Fyn	0	4	0	4
Procathepsin L	0	2	1	3
Aldo-keto reductase family 1 member B1	0	10	0	10
ATP-dependent translocase ABCB1	0	7	0	14
5-hydroxytryptamine receptor 1A	0	2	1	3
Alpha-2A adrenergic receptor	0	8	1	9
Replicase polyprotein 1a	0	2	1	3
Replicase polyprotein 1ab	0	2	1	3
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	2	1	3
Polyunsaturated fatty acid lipoxygenase ALOX15	0	6	0	6
Angiotensin-converting enzyme	0	5	0	5
D(2) dopamine receptor	0	9	0	10
5-hydroxytryptamine receptor 2A	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-1	9	4	1	14
Alpha-1B adrenergic receptor	0	8	0	8
Sphingomyelin phosphodiesterase	0	1	0	1
Alpha-2B adrenergic receptor	0	8	0	8
Gamma-aminobutyric acid receptor subunit delta	9	4	1	14
Gamma-aminobutyric acid receptor subunit gamma-2	9	4	1	14
Alpha-2C adrenergic receptor	0	6	0	6
D	0	3	0	3
D(3) dopamine receptor	0	4	0	4
5-hydroxytryptamine receptor 1A	0	9	0	9
Alpha-2B adrenergic receptor	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	9	4	1	14
Gamma-aminobutyric acid receptor subunit alpha-3	9	4	1	14
D(2) dopamine receptor	0	1	0	1
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	6	0	6
D(1A) dopamine receptor	0	8	0	9
D(4) dopamine receptor	0	9	0	10
D(1B) dopamine receptor	0	1	0	2
Adenylate cyclase type 3	0	2	0	2
Alpha-2C adrenergic receptor	0	3	0	3
UDP-glucuronosyltransferase 1A4	0	1	0	3
Alpha-2A adrenergic receptor	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-1	9	4	1	14
Gamma-aminobutyric acid receptor subunit alpha-2	9	4	1	14
Alpha-1D adrenergic receptor	0	5	0	5
Sodium-dependent noradrenaline transporter	0	11	0	11
Sodium-dependent dopamine transporter	0	2	0	2
Histamine H2 receptor	0	2	0	2
D(1B) dopamine receptor	0	2	0	2
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	2	0	2
Adenylate cyclase type 4	0	2	0	2
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
5-hydroxytryptamine receptor 2A	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-4	9	4	1	14
Gamma-aminobutyric acid receptor subunit gamma-3	9	4	1	14
5-hydroxytryptamine receptor 1B	0	4	0	4
Trypanothione reductase	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	9	4	1	14
D(4) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 2B	0	3	0	3
Histamine H1 receptor	0	2	0	2
Sodium-dependent serotonin transporter	0	12	0	12
Melanocortin receptor 4	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Melanocortin receptor 5	0	4	0	4
Pleiotropic ABC efflux transporter of multiple drugs	0	2	0	4
5-hydroxytryptamine receptor 7	0	2	0	2
Histamine H1 receptor	0	7	1	8
Mu-type opioid receptor	0	8	2	11
Glutamate receptor ionotropic, NMDA 1	0	3	1	5
D(3) dopamine receptor	0	9	0	10
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	2	0	3
Adenylate cyclase type 8	0	2	0	2
Proteasome subunit beta type-10	0	0	0	1
Delta-type opioid receptor	0	8	1	10
Kappa-type opioid receptor	0	8	1	10
5-hydroxytryptamine receptor 2B	0	12	0	12
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	8	0	8
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
5-hydroxytryptamine receptor 6	0	8	0	8
Gastrin/cholecystokinin type B receptor	0	1	0	1
Proteasome subunit alpha type-6	0	0	1	2
D(2) dopamine receptor	0	4	1	6
Calmodulin	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	9	4	1	14
Gamma-aminobutyric acid receptor subunit beta-2	9	4	1	14
Aldehyde oxidase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	3	1	5
Glutamate receptor ionotropic, NMDA 2B	0	3	1	5
Glutamate receptor ionotropic, NMDA 2C	0	3	1	5
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Sodium-dependent dopamine transporter	0	6	0	6
Adenylate cyclase type 6	0	2	0	2
Adenylate cyclase type 5	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Aldehyde oxidase	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	10	0	10
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Sodium channel protein type 5 subunit alpha	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	3	1	5
Nuclear receptor subfamily 3 group C member 3	0	5	0	5
Adenylyl cyclase 7	0	2	0	2
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	3	1	5
GABA theta subunit	9	4	1	14
D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Proteasome subunit beta type-7	0	0	0	1
Angiotensin-converting enzyme 2	0	2	1	3
Gamma-aminobutyric acid receptor subunit epsilon	9	4	1	14
Sodium channel protein type 3 subunit alpha	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	3	1	5
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Histamine H3 receptor	0	2	0	2
Sodium channel protein type 10 subunit alpha	0	1	0	1
Chain A, Beta-lactamase	6	0	0	6
endonuclease IV	5	0	0	5
PAX8	0	0	0	1
pregnane X receptor	7	0	0	7
PPM1D protein	2	0	0	2
aryl hydrocarbon receptor	13	0	0	13
nuclear receptor subfamily 0 group B member 1	0	1	0	1
cytochrome P450 2C19 precursor	5	0	0	5
cytochrome P450 2C9 precursor	4	0	0	4
flap endonuclease 1	10	0	0	10
steroidogenic factor 1	0	1	0	1
caspase-1 isoform alpha precursor	2	0	0	2
Solute carrier family 22 member 3	0	1	0	1
Tubulin alpha-1A chain	0	2	2	5
Tubulin beta chain	0	2	2	4
Plasma kallikrein	0	0	0	2
Tubulin beta-4A chain	0	3	3	8
ATP-dependent translocase ABCB1	0	2	0	2
Tubulin beta chain	0	3	3	8
Cytochrome P450 3A4	0	4	2	6
Tubulin alpha-3C chain	0	3	3	8
Serine/threonine-protein kinase pim-1	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	3
Tubulin alpha-1B chain	0	3	3	8
Tubulin alpha-4A chain	0	3	3	8
Tubulin beta-4B chain	0	3	3	8
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	4	3	9
Tubulin beta-2A chain	0	3	3	8
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	3	3	8
Tubulin beta-2B chain	0	2	1	5
Tubulin alpha-3E chain	0	3	3	8
Tubulin alpha-1A chain	0	3	3	8
Similar to alpha-tubulin isoform 1	0	1	1	4
Similar to alpha-tubulin isoform 1	0	1	0	3
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	3	3	8
Tubulin beta-6 chain	0	3	3	8
Tubulin beta-2B chain	0	3	3	8
Tubulin beta-1 chain	0	3	3	8
15-lipoxygenase, partial	4	0	0	4
RAD51	0	1	0	1
huntingtin isoform 2	4	0	0	4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	0	1	0	1
Caspase-7	2	0	0	2
Growth factor receptor-bound protein 2	0	1	0	1
Pantothenate synthetase	0	1	0	1
Discoidin domain-containing receptor 2	0	1	0	1
Growth factor receptor-bound protein 2	0	1	0	1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	0	0	1	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
runt-related transcription factor 1 isoform AML1b	2	0	0	2
core-binding factor subunit beta isoform 2	2	0	0	2
Glutamate receptor 1	1	0	0	1
Glutamate receptor 3	1	0	0	1
Glutamate receptor 4	1	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
apical membrane antigen 1, AMA1	5	0	0	5
nonstructural protein 1	6	0	0	6
pyruvate kinase	2	0	0	2
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
LacZ protein (plasmid)	0	0	1	1
thyrotropin-releasing hormone receptor	3	0	0	3
beta-2 adrenergic receptor	2	0	0	2
type-1 angiotensin II receptor	0	1	0	1
perilipin-5	0	1	0	1
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
perilipin-1	0	1	0	1
polypyrimidine tract-binding protein 1 isoform a	1	0	0	1
serine/threonine-protein kinase PLK1	3	0	0	3
apelin receptor	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	3
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Vpr	4	0	0	4
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase	0	1	0	1
pyruvate kinase PKM isoform b	1	0	0	1
Fatty-acid amide hydrolase 1	0	2	0	2
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Carbamate kinase	0	1	0	1
Retinal dehydrogenase 1	0	1	0	1
Amyloid-beta precursor protein	2	1	0	3
Aldehyde dehydrogenase, mitochondrial	0	1	0	1
Ornithine decarboxylase	1	0	0	2
C-X-C chemokine receptor type 2	0	2	0	2
Mitogen-activated protein kinase 3	0	1	0	1
Lysine-specific demethylase 5A	0	1	0	1
Caspase-1	0	1	0	1
Alpha-synuclein	2	3	0	5
C-C chemokine receptor type 2	0	2	0	2
C-C chemokine receptor type 4	0	2	0	2
C-C chemokine receptor type 5	0	2	0	2
Gasdermin-D	0	1	0	1
Inositol monophosphatase 1	5	0	0	5
TAR DNA-binding protein 43	6	0	0	6
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
Monoglyceride lipase	0	1	0	1
Gasdermin-D	0	1	0	1
Histone-lysine N-methyltransferase EHMT1	0	1	0	1
heat shock protein 90, putative	0	0	0	2
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
large T antigen	0	1	0	1
Estrogen receptor	0	6	0	6
Sex hormone-binding globulin	0	0	2	2
Corticosteroid-binding globulin	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	2
Solute carrier organic anion transporter family member 1A1	0	2	0	2
Lanosterol 14-alpha demethylase	0	0	1	1
Olfactory receptor 51E2	0	0	3	3
UDP-glucuronosyltransferase 1A10	0	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Delta-type opioid receptor	0	4	0	5
Delta-type opioid receptor	0	5	1	7
Mu-type opioid receptor	0	6	2	11
Kappa-type opioid receptor	0	3	1	5
Kappa-type opioid receptor	0	4	0	4
Mu-type opioid receptor	0	3	1	6
Mu-type opioid receptor	0	5	0	5
Sigma non-opioid intracellular receptor 1	0	4	0	4
interferon gamma precursor	0	0	0	1
streptokinase A precursor	0	0	1	1
Sodium/nucleoside cotransporter 2	0	1	0	1
Thymidylate synthase	0	3	0	4
Thymidine phosphorylase	0	0	0	3
Solute carrier family 15 member 1	0	2	0	2
Thymidine kinase	0	0	0	3
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	3
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	3
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	3
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	2	5
Gamma-aminobutyric acid receptor subunit beta-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	2	5
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	3
Gamma-aminobutyric acid receptor subunit beta-3	0	3	2	5
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	2	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	2	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	1	3
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
glp-1 receptor, partial	5	0	0	5
Skn7p	0	0	0	1
Solute carrier family 22 member 8	0	0	0	1
Aromatase	0	1	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Chain A, Dihydrofolate reductase	0	0	1	1
acid sphingomyelinase	1	0	0	1
alpha-galactosidase	1	0	0	1
lysosomal alpha-glucosidase preproprotein	3	0	0	3
Thymidylate synthase	0	2	0	2
Aldo-keto reductase family 1 member B1	0	2	0	2
Multidrug resistance associated protein	0	0	0	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	3	0	3
Proton-coupled amino acid transporter 1	0	3	0	4
Serine racemase	0	1	0	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
Carbonic anhydrase	0	1	0	1
Hsf1 protein	0	0	1	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 3	0	2	0	3
Carbonic anhydrase 6	0	2	0	3
Carbonic anhydrase 5A, mitochondrial	0	2	0	3
Carbonic anhydrase 7	0	2	0	3
Guanine nucleotide-binding protein G	3	0	0	3
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Carbonic anhydrase 13	0	2	0	3
Carbonic anhydrase 14	0	2	0	3
Carbonic anhydrase 5B, mitochondrial	0	2	0	3
Chymotrypsinogen A	0	1	0	1
Parkin	2	0	0	2
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
dopamine D1 receptor	1	0	0	1
WRN	2	0	0	2
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
DNA polymerase eta isoform 1	3	0	0	3
Polyphenol oxidase 2	0	1	0	3
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosinase	0	1	0	1
Carbonic anhydrase	0	0	0	1
SLC16A10 protein	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
phosphoglycerate kinase	2	0	0	2
inositol monophosphatase 1	1	0	0	1
Cholecystokinin receptor type A	1	0	0	1
Gastrin/cholecystokinin type B receptor	1	0	0	1
Glycogen synthase kinase-3 beta	0	1	1	2
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
Cannabinoid receptor 1	0	2	0	2
Opioid receptor, delta 1b	0	1	0	1
Acetylcholinesterase	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Translocator protein	0	0	1	1
Histidine decarboxylase	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Sodium-dependent serotonin transporter	0	1	0	1
Kappa-type opioid receptor	0	2	1	4
UDP-glucuronosyltransferase 1A3	0	0	0	1
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	2	2
Mu-type opioid receptor	0	1	0	1
Estrogen receptor	0	0	1	1
Progesterone receptor	0	2	2	4
Estrogen receptor beta	0	0	1	1
5-hydroxytryptamine receptor 3E	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Alpha-1A adrenergic receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Transporter	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
Transporter	0	1	0	1
Genome polyprotein	0	1	0	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
Tyrosine-protein kinase ABL1	0	1	0	1
Integrin alpha-V	0	1	0	1
60 kDa chaperonin	0	2	0	2
Botulinum neurotoxin type A	0	1	0	1
Apoptosis regulator Bcl-2	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	2	0	2
Fibroblast growth factor receptor 1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	2	0	2
Serum paraoxonase/arylesterase 1	0	1	0	1
Cholecystokinin receptor type A	0	2	0	2
UDP-glucuronosyltransferase 2B10	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	2	0	2
Bcl-2-like protein 1	0	1	0	1
Tyrosine-protein kinase Mer	0	1	0	1
Thiosulfate sulfurtransferase	0	2	0	2
Beta-tubulin	0	1	0	1
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
Nucleotide-binding oligomerization domain-containing protein 2	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	2	0	3
Geranylgeranyl pyrophosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	1	0	1
Farnesyl pyrophosphate synthase	0	1	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Gamma-aminobutyric acid	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Mcl-1	0	1	0	1
neutrophil cytosol factor 1	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	2	0	3
Solute carrier organic anion transporter family member 1A4	0	1	0	2
Solute carrier family 22 member 2	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Solute carrier family 22 member 1	0	2	0	3
Cytochrome P450 2D4	0	1	0	1
Solute carrier family 22 member 2	0	2	0	2
Sphingosine kinase 2	0	2	0	2
Sphingosine kinase 1	0	1	0	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	1	1	2
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
Protein-arginine deiminase type-4	0	4	0	4
MPI protein	0	1	0	1
serine-protein kinase ATM isoform a	2	0	0	2
galactokinase	1	0	0	1
protein-arginine deiminase type-4	0	1	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Vif	0	1	0	1
Tat	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
DNA repair and recombination protein RAD54-like	0	0	1	1
Sentrin-specific protease 6	0	1	0	1
Sentrin-specific protease 2	0	1	0	1
Sentrin-specific protease 1	0	1	0	1
Protein-arginine deiminase type-1	0	1	0	1
Protein-arginine deiminase type-3	0	1	0	1
Protein-arginine deiminase type-2	0	1	0	1
Substance-P receptor	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Substance-K receptor	0	1	1	2
Substance-P receptor	0	2	1	3
Neuromedin-K receptor	0	1	1	2
Substance-K receptor	0	1	0	1
Substance-K receptor	0	1	0	1
Growth hormone secretagogue receptor type 1	0	0	1	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Neutrophil collagenase	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Integrase	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Cereblon isoform 4	0	2	0	2
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
Cytochrome P450 2B1	0	1	0	1
Cytochrome P450 2B6	0	1	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
Urease	0	2	0	3
Urease subunit alpha	0	2	0	2
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	2	0	2
Urease subunit beta	0	1	0	1
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	2	4	6
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Interleukin-8	0	1	0	1
Lactoylglutathione lyase	0	1	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Ornithine decarboxylase	0	0	0	1
Retinoic acid receptor alpha	0	2	2	7
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Retinoic acid receptor gamma	0	2	2	7
Alpha-1A adrenergic receptor	0	1	0	1
Retinoic acid receptor gamma	0	1	2	3
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nuclear receptor ROR-alpha	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	0	1	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(8)

Research Excerpts

Overview

Treatment

Research

Studies (303)

Protein Targets (1,007)

Clubfeet

Synonyms(8)

Research Excerpts

Overview

Treatment

Research

Studies (303)

Drugs Studied (130)

Protein Targets (1,007)