Page last updated: 2024-11-12

urushiol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Cross-References

ID SourceID
PubMed CID44144477
MeSH IDM0044843

Synonyms (4)

Synonym
urushiol ,
hsdb 7485
53237-59-5
3-[(8e,11e)-pentadeca-8,11-dienyl]benzene-1,2-diol;3-[(8e,11e)-pentadeca-8,11,14-trienyl]benzene-1,2-diol;3-[(8e,11e,13e)-pentadeca-8,11,13-trienyl]benzene-1,2-diol;3-[(e)-pentadec-8-enyl]benzene-1,2-diol;3-pentadecylbenzene-1,2-diol

Research Excerpts

Toxicity

ExcerptReferenceRelevance
"Skin irritation is one of the most common adverse reactions in hydroquinone (HQ) and retinoic acid (RA)."( S100B as a potential biomarker for the detection of cytotoxicity of melanocytes.
Cheong, KA; Kim, CH; Lee, AY; Noh, M, 2014
)
0.4

Bioavailability

ExcerptReferenceRelevance
"The aim of this study was to develop a means of improving the bioavailability and anticancer activity of urushiol by developing an urushiol-loaded novel tumor-targeted micelle delivery system based on amphiphilic block copolymer poly(ethylene glycol)-b-poly-(β-amino ester) (mPEG-PBAE)."( Novel pH-Sensitive Urushiol-Loaded Polymeric Micelles for Enhanced Anticancer Activity.
Qi, Z; Wang, C; Xue, X; Zhou, H, 2020
)
0.56

Dosage Studied

Both oral and epicutaneous administration produced hyposensitization to urushiol after weak sensitization by EF. All doses of urushio resulted in a local reaction, and severity of reactions was correlated with dosage of urUSHiol used in the patch test.

ExcerptRelevanceReference
" High doses produced a greater degree of hyposensitization regardless of the dosage schedule used."( Immunologic studies of poisonous Anacardiaceae: oral desensitization to poison ivy and oak urushiols in guinea pigs.
ElSohly, MA; Murphy, JC; Watson, ES, 1983
)
0.27
"The relative alkylation index (RAI), a theoretically derived parameter intended to quantify the relative extent of carrier haptenation resulting from a given dose of a given sensitizer, has previously been successfully applied to the analysis of relative sensitization potential and dose-response data for a variety of contact allergens which are directly electrophilic."( Quantitative structure-activity relationships for skin sensitization potential of urushiol analogues.
Benezra, C; Roberts, DW, 1993
)
0.29
" During the observation period of 10 weeks, both oral and epicutaneous administration produced hyposensitization to urushiol after weak sensitization by EF; however, only combined administrations via the oral and epicutaneous routes achieved hyposensitization after potent sensitization, while inadequate tolerance was induced by oral dosing and none by epicutaneous dosing."( Oral and epicutaneous desensitization in urushiol contact dermatitis in guinea pigs sensitized by 2 methods of different sensitizing potency.
Ikeda, Y; Kawai, K; Sato, A; Yasuno, H, 1998
)
0.3
" All doses of urushiol resulted in a local reaction, and severity of reactions was correlated with dosage of urushiol used in the patch test."( Urushiol Patch Test Using the T.R.U.E. TEST System.
ElSohly, MA; Gul, W; Hage, RJ; Hamann, CP; Kim, Y; Longenecker, A; Marks, JG,
)
0.13
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (136)

TimeframeStudies, This Drug (%)All Drugs %
pre-199038 (27.94)18.7374
1990's36 (26.47)18.2507
2000's15 (11.03)29.6817
2010's33 (24.26)24.3611
2020's14 (10.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials9 (6.12%)5.53%
Reviews8 (5.44%)6.00%
Case Studies9 (6.12%)4.05%
Observational1 (0.68%)0.25%
Other120 (81.63%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]