triazoles has been researched along with zm 241385 in 347 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 43 (12.39) | 18.2507 |
| 2000's | 194 (55.91) | 29.6817 |
| 2010's | 105 (30.26) | 24.3611 |
| 2020's | 5 (1.44) | 2.80 |
| Authors | Studies |
|---|---|
| Brooks, R; Collis, MG; Keddie, JR; Poucher, SM; Shaw, GR | 1 |
| Hourani, SM; Prentice, DJ | 2 |
| Brooks, R; Keddie, JR; McKillop, D; Poucher, SM; Shaw, GR | 1 |
| Jacobson, KA; Palmer, TM; Poucher, SM; Stiles, GL | 1 |
| Poucher, SM | 2 |
| Dixon, AK; Richardson, PJ; Widdowson, L | 1 |
| Apasov, S; Huang, S; Kojima, H; Koshiba, M; Sitkovsky, MV | 1 |
| Constantino, MD; Cunha, RA; Ribeiro, JA | 2 |
| Hourani, SM; Payne, SL; Prentice, DJ | 1 |
| McGrath, JC; Moore, FP; Thomson, NC | 1 |
| Fukamachi, H; Nakahata, T; Suzuki, H; Takei, M | 1 |
| Conforti, L; Kobayashi, S; Millhorn, DE; Pun, RY | 1 |
| Coney, AM; Marshall, JM | 1 |
| Jones, PA; Smith, RA; Stone, TW | 2 |
| Baraldi, PG; Borea, PA; Cacciari, B; Dionisotti, S; Ongini, E; Varani, K | 1 |
| Baker, SP; Baraldi, PG; Belardinelli, L; Cacciari, B; Monopoli, A; Ongini, E; Shryock, JC; Snowdy, S; Spalluto, G | 1 |
| O'Regan, MH; Phillis, JW; Song, D | 1 |
| Bryan, PT; Marshall, JM | 1 |
| O'Kane, EM; Stone, TW | 1 |
| Cutler, BS; Dobson, JG; Fenton, RA; Li, Jm; Peyton, BD; Powell, CC; Wheeler, HB | 1 |
| Dionisotti, S; Fredholm, BB; Gessi, S; Irenius, E; Ongini, E | 1 |
| Chung, ES; Dobson, JG; Fenton, RA; Honeyman, TW; Lorbar, M; McGinn, RJ; Meyer, TE; Norton, GR; Woodiwiss, AJ | 1 |
| Cseppentö, A; Kovács, P; Nagy, E; Szabó, JZ; Szentmiklósi, AJ; Ujfalusi, A | 1 |
| Huang, L; Linden, J; Macdonald, T; Okusa, MD | 1 |
| Cunha, RA; Lopes, LV; Ribeiro, JA | 3 |
| Fredholm, BB; Lindström, K | 1 |
| Buster, BL; Linden, J; Scheld, WM; Sullivan, GW | 1 |
| Benovic, JL; Kelly, E; Parent, JL; Willets, JM | 1 |
| Palmer, TM; Stiles, GL | 1 |
| Bordoni, F; Corradetti, R; Latini, S; Pedata, F; Pepeu, G | 1 |
| Enyeart, JJ; Xu, L | 1 |
| Brunsden, AM; Grundy, D | 1 |
| Davie, CS; Everitt, DE; Standen, NB | 1 |
| Fei, Q; Loutzenhiser, R; Parker, M; Tang, L | 1 |
| Jacobson, KA; Ji, XD | 1 |
| Harada, N; Katsuragi, T; Okajima, K | 1 |
| Dashwood, MR; Spyer, KM; St Lambert, JH; Thomas, T | 1 |
| Costentin, J; El Yacoubi, M; Ledent, C; Parmentier, M; Vaugeois, JM | 1 |
| Hong, KW; Shin, HK; Shin, YW | 1 |
| Abebe, W; Arif Hasan, AZ; Mustafa, SJ | 1 |
| Jabbari-T, J; Oberhauser, V; Rump, LC; von Kügelgen, I | 1 |
| Cunha, RA; Pereira, MF; Ribeiro, JA | 1 |
| Clark, KL; Guyton, RA; Nakamura, M; Velez, DV; Vinten-Johansen, J; Zhao, ZQ | 1 |
| Anderson, R; Ramafi, G; Theron, AJ; Visser, SS | 1 |
| Olah, ME; Roudabush, FL | 1 |
| Agostinho, P; Cunha, RA; Melo, J; Oliveira, CR; Rego, AC | 1 |
| Matsuki, N; Nakazawa, K; Ohno, Y; Sato, K | 1 |
| Costentin, J; El Yacoubi, M; Ledent, C; Parmentier, M; Vaugeois, J | 1 |
| Feoktistov, I; Mustafa, SJ; Olanrewaju, HA; Qin, W; Scemama, JL | 1 |
| Gao, ZG; Ijzerman, AP; Jacobson, KA; Jiang, Q | 1 |
| Gao, ZG; Ijzerman, AP | 1 |
| Harada, N; Katsuragi, T; Murakami, K; Ohshima, K; Okajima, K; Sato, C; Usune, S | 1 |
| Cunha, RA; Hernández, MD; Miras-Portugal, MT; Pereira, MF; Pintor, J; Ribeiro, JA | 1 |
| Koos, BJ; Maeda, T | 2 |
| Kaszkin, M; Pfeilschifter, J; Scholz-Pedretti, K | 1 |
| Hein, TW; Kuo, L; Muthuchamy, M; Wang, W; Zoghi, B | 1 |
| Alexander, SP; Millns, PJ | 1 |
| Costentin, J; Daoust, M; El Yacoubi, M; Ledent, C; Parmentier, M; Vaugeois, J | 1 |
| Linden, J; Macdonald, TL; Rieger, JM; Scheld, WM; Sullivan, GW | 1 |
| Coyne, EF; Meno, JR; Ngai, AC; West, GA; Winn, HR | 1 |
| Barringhaus, KG; Bishop, GG; Gimple, LW; Hesselbacher, SE; Linden, J; Macdonald, T; McPherson, JA; Powers, ER; Rieger, JM; Sanders, JM; Sarembock, IJ; Sullivan, G | 1 |
| Linden, J; Macdonald, TL; Peirce, SM; Rieger, JM; Skalak, TC | 1 |
| Jan, C; Koos, BJ; Maeda, T | 1 |
| Baker, SP; Belardinelli, L; Blackburn, B; Elzein, E; Gao, Z; Lasley, RD; Li, Z; Meyer, S; Palle, V; Zablocki, JA | 1 |
| Bernardi, G; Calabresi, P; Centonze, D; Pisani, A; Saulle, E | 1 |
| Nikbakht, MR; Stone, TW | 1 |
| Hamann, M; Richter, A | 1 |
| Breschi, MC; Calderone, V; Martinotti, E; Nieri, P | 1 |
| Culmsee, C; Kemp, BE; Mattson, MP; Monnig, J | 1 |
| Crum, AV; Meno, JR; Winn, HR | 1 |
| Inoue, H; Kikkawa, K; Mochida, H; Noto, T | 1 |
| Edmunds, NJ; Marshall, JM | 1 |
| Harvey, V; Jones, J; Knight, AR; Misra, A; Quirk, K | 1 |
| Furue, H; Kumamoto, E; Lao, LJ; Luo, C; Yoshimura, M | 1 |
| Grisshammer, R; Weiss, HM | 1 |
| Higashi, H; Marwaha, AS; Meno, JR; Winn, HR | 1 |
| Ellis, KM; Fozard, JR; Mazzoni, L; Tigani, B; Villela Dantas, MF | 1 |
| Jan, C; Koos, BJ; Lopez, G; Maeda, T | 1 |
| Cunha, RA; Fredholm, BB; Kull, B; Lopes, LV; Ribeiro, JA | 1 |
| Belem, PC; Chen, JF; Cronstein, B; Elson, G; Fink, JS; Jacobson, M; Leibovich, SJ; Montesinos, C; Pinhal-Enfield, G; Ramanathan, M; Rosania, A; Schwarzschild, MA | 1 |
| Gao, ZG; IJzerman, AP; Jacobson, KA; Kim, SG; Melman, N; Soltysiak, KA | 1 |
| Bril, A; Broadley, KJ; Khandoudi, N; Maddock, HL | 1 |
| Chicz-DeMet, A; DeMet, EM | 1 |
| Cunha, RA; Oliveira, CR; Rebola, N | 1 |
| Daoust, M; Ledent, C; Naassila, M | 1 |
| Borea, PA; Cattabriga, E; Iannotta, V; Manfredini, R; Pancaldi, C; Portaluppi, F; Uluoglu, C; Varani, K | 1 |
| Abbracchio, MP; Borea, PA; Camurri, A; Capecchi, PL; Cattabeni, F; Ceccatelli, L; Diciolla, F; Laghi-Pasini, F; Lazzerini, PE; Maccherini, M; Ulouglu, C; Varani, K | 1 |
| D'Ambrosio, R; Iliff, JJ; Ngai, AC; Winn, HR | 1 |
| Diniz, C; Gonçalves, J; Leal, S | 1 |
| Duling, BR; Linden, J; Platts, SH | 1 |
| Antoniou, K; Ferré, S; Fuxe, K; Goldberg, SR; Justinova, Z; Karcz-Kubicha, M; Müller, CE; Pezzola, A; Popoli, P; Quarta, D; Reggio, R; Solinas, M; Terasmaa, A | 1 |
| Cunha, RA; Dall'Igna, OP; Dall'lgna, OP; Lara, DR; Porciúncula, LO; Souza, DO | 1 |
| Adamski, D; Berger, F; Charles, MP; Kholler, B; Pelletier, L; Wion, D | 1 |
| Boehm, S; Freissmuth, M; Just, H; Klinger, M; Korkhov, VM; Kudlacek, O; Nanoff, C; Pankevych, H; Vartian, N; Yang, Q | 1 |
| Fredholm, BB; Hellsten, Y; Lynge, J; Nordsborg, N; Schulte, G | 1 |
| Cunha, RA; de Mendonca, A; Oliveira, CR; Rebola, N; Ribeiro, JA; Sebastião, AM | 1 |
| O'Regan, MH; Phillis, JW | 1 |
| Corradetti, R; Latini, S; Pedata, F; Pugliese, AM | 1 |
| Brodmann, M; Lischnig, U; Lueger, A; Pilger, E; Stark, G | 1 |
| Addae, JI; Stone, TW; Youssef, FF | 1 |
| Mustafa, JS; Rekik, M | 1 |
| Costentin, J; El Yacoubi, M; Vaugeois, JM | 1 |
| Benwell, K; Cliffe, IA; Dourish, CT; Gillespie, RJ; Knight, AR; Lerpiniere, J; Misra, A; Pratt, RM; Revell, D; Upton, R; Weiss, SM | 1 |
| Day, YJ; Huang, L; Linden, J; Marshall, MA; McDuffie, MJ; Okusa, MD | 1 |
| Brooke, RE; Deuchars, J; Deuchars, SA | 1 |
| Goulart, EC; Kaster, MP; Rodrigues, AL; Rosa, AO; Rosso, MM; Santos, AR | 1 |
| Furuta, S; Honma, I; Kumagai, M; Miyazaki, S; Onodera, K; Sakurada, S; Sato, T | 1 |
| Kwok, YN; Yip, L | 1 |
| Abebe, W; Mozaffari, MS | 1 |
| Easton, AS; Inglis, VI; Jones, MP; Tse, AD | 1 |
| Bier, D; Coenen, HH; Holschbach, MH; Olsson, RA; Schulze, A; Sihver, W; Wutz, W | 1 |
| Galluzzo, M; Grieco, R; Pèzzola, A; Pintor, A; Popoli, P; Reggio, R | 1 |
| Diógenes, MJ; Fernandes, CC; Ribeiro, JA; Sebastião, AM | 1 |
| Konishi, S; Rusakov, D; Saitow, F; Satake, S | 1 |
| Etherington, LA; Frenguelli, BG | 1 |
| Ho, CM; Ho, ST; Peng, SC; Su, CK; Tsai, SK | 1 |
| Awadallah, NW; Chan, ES; Cronstein, BN; Montesinos, MC; Rahman, MM; Reiss, AB | 1 |
| Domenici, MR; Frank, C; Grieco, R; Martire, A; Pepponi, R; Pintor, A; Popoli, P; Potenza, RL; Tebano, MT | 1 |
| Barbu, DE; Lungu, CL; O'Regan, MH; Phillis, JW | 1 |
| Dziubina, A; Gołembiowska, K | 3 |
| Domenici, MR; Martire, A; Pepponi, R; Popoli, P; Potenza, RL; Tebano, MT | 1 |
| Batista, LC; Prediger, RD; Takahashi, RN | 1 |
| Bailey, A; Hourani, S; Kelly, M; Kitchen, I; Ledent, C | 1 |
| Colgan, SP; Eltzschig, HK; Ibla, JC; Morote-Garcia, JC; Resta, R; Thompson, LF; Van De Wiele, CJ | 1 |
| Bohorquez, F; Kawasaki, Y; Kim, YH; Koos, BJ | 1 |
| Lappas, CM; Linden, J; Rieger, JM | 1 |
| Briones, R; Donoso, MV; Huidobro-Toro, JP; López, R; Miranda, R | 1 |
| Ballard-Croft, C; Keith, BJ; Kristo, G; Lasley, RD; Mentzer, RM; Reid, EA; Yoshimura, Y | 1 |
| Fuxe, K; Rinken, A; Terasmaa, A; Uustare, A; Vonk, A | 1 |
| Ackley, MA; Baldwin, SA; King, AE | 1 |
| Abbracchio, MP; Camurri, A; Capecchi, PL; Diciolla, F; Laghi-Pasini, F; Lazzerini, PE; Maccherini, M; Mazzola, A; Pompella, G | 1 |
| Prediger, RD; Takahashi, RN | 1 |
| Hikichi, T; Kawahara, A; Kitaya, N; Mori, F; Takahashi, J; Yoshida, A | 1 |
| Fernandes, D; Prediger, RD; Takahashi, RN | 1 |
| Bonan, CD; Cammarota, M; Izquierdo, I; Pereira, GS; Rossato, JI; Sarkis, JJ | 1 |
| Arun, KH; Kaul, CL; Kumar, S; Sharma, SS | 1 |
| Herrera, S; Kasza, K; Mendelson, WB; Szafran, MJ; Tung, A | 1 |
| Amerson, BS; Guyton, RA; Halkos, ME; Headrick, JP; Kerendi, F; Kin, H; Lofye, MT; Vinten-Johansen, J; Zatta, AJ; Zhao, ZQ | 1 |
| Boeck, CR; Bronzatto, MJ; Kroth, EH; Vendite, D | 1 |
| Almeida, T; Cunha, RA; Oliveira, CR; Richardson, PJ; Rodrigues, RJ | 1 |
| Linden, J; Marshall, MA; Murphree, LJ; Sullivan, GW | 1 |
| Angulo, E; Casadó, V; Chen, JF; Ejarque, A; Franco, R; Lluis, C; Moratalla, R; Saura, J; Schwarzschild, MA; Serratosa, J; Tusell, JM | 1 |
| Belardinelli, L; Biaggioni, I; Dhalla, AK; Wang, WQ; Wong, MY | 1 |
| Marshall, JM; Ray, CJ | 3 |
| Deussen, A; Frøbert, O; Gravholt, CH; Haink, G; Levin, M; Simonsen, U | 1 |
| Fathollahi, Y; Mirnajafi-Zadeh, J; Namvar, S; Rezvani, ME; Zeraati, M | 1 |
| Allen-Gipson, DS; Sisson, JH; Spurzem, JR; Wong, J; Wyatt, TA | 1 |
| Antonioli, L; Blandizzi, C; Colucci, R; Del Tacca, M; Fornai, M; Ghisu, N | 1 |
| Cheng, JJ; Huang, NK; Lai, WL; Lin, YR; Lu, MK | 1 |
| Alexander, SP; Beckett, SR; Harper, LK; Marsden, CA; McCreary, AC | 1 |
| Baghdoyan, HA; Coleman, CG; Lydic, R | 1 |
| Fang, X; Gao, N; Hu, HZ; Liu, S; Wang, GD; Wang, XY; Wood, JD; Xia, Y | 1 |
| Ay, I; Tuncer, M | 1 |
| Csóka, B; Deitch, EA; Haskó, G; Ledent, C; Lu, Q; Németh, ZH; Pacher, P; Spolarics, Z; Wilmanski, J; Xu, D | 1 |
| Abbracchio, MP; Bates, G; Borea, PA; Camurri, A; Cattaneo, E; Tarditi, A; Varani, K; Woodman, B | 1 |
| Aceves, J; Erlij, D; Florán, B; Florán, L; Gonzalez, B; Paz, F | 1 |
| Greengard, P; Higashi, H; Kuroiwa, M; Nishi, A; Shuto, T; Snyder, GL; Sotogaku, N; Tanaka, M; Yabuuchi, K | 1 |
| O'Leary, DS; Scislo, TJ | 1 |
| Koos, BJ; Kruger, L; Linden, J; Murray, TF; Yan, X | 1 |
| Day, YJ; Kern, JA; Li, Y; Linden, J; Liu, L; Oskouian, RJ; Rieger, JM | 1 |
| Chan, ES; Chen, JF; Cronstein, BN; Delano, DL; Desai, A; Fernandez, P; Friedman, SL; Montesinos, MC; Pillinger, MH; Reiss, AB; Schwarzschild, MA; Yee, H | 1 |
| Conde, SV; Gonzalez, C; Obeso, A; Rigual, R; Rocher, A; Vicario, I | 1 |
| Brown, R; Fredholm, BB; Lai, EY; Mrowka, R; Patzak, A; Persson, AE; Persson, PB; Spielmann, N; Steege, A | 1 |
| Huxley, VH; Wang, J | 1 |
| Chan, ES; Chen, JF; Cronstein, BN; Desai, A; Fernandez, P; Khoa, DN; Merchant, AA; Montesinos, MC; Pillinger, MH; Reiss, AB; Schwarzschild, MA; Tomic-Canic, M; Trzaska, S; Tung, CF | 1 |
| Ellman, PI; Kern, JA; Kron, IL; Laurent, JJ; Linden, J; Maxey, TS; Okonkwo, DO; Reece, TB; Tache-Leon, C; Tribble, CG | 1 |
| Baunez, C; Bernardi, G; Calabresi, P; Centonze, D; De Chiara, V; Gubellini, P; Picconi, B; Prosperetti, C; Rossi, S; Tscherter, A | 1 |
| Keith, BJ; Kristo, G; Lasley, RD; Mentzer, RM | 1 |
| Auchampach, JA; Ge, ZD; Gross, GJ; Jacobson, MA; Kreckler, LM; Peart, JN; Wan, TC | 1 |
| Grden, M; Kocbuch, K; Pawelczyk, T; Podgorska, M; Szutowicz, A | 1 |
| Gao, C; Gao, N; Hu, HZ; Liu, S; Wood, JD; Xia, Y | 1 |
| Cunha-Reis, D; Fontinha, BM; Ribeiro, JA; Sebastião, AM | 1 |
| Hao, I; Leibovich, SJ; Pinhal-Enfield, G; Ramanathan, M | 1 |
| Beukers, MW; Blad, CC; Brouwer, J; den Dulk, H; Ijzerman, AP; Li, Q; Ye, K | 1 |
| Bairam, A; Kinkead, R; Montandon, G | 2 |
| Fatokun, AA; Smith, RA; Stone, TW | 1 |
| Einav, S; Galun, E; Linden, J; Matot, I; Rivo, J; Zeira, E | 1 |
| Behan, WM; Stone, TW | 1 |
| Agnati, L; Filip, M; Franco, R; Fuxe, K; Lluís, C; Marcellino, D; Navarro, G; Roberts, DC | 1 |
| Biskup, W; Celiński, K; Cichoz-Lach, H; Czechowska, G; Korobowicz, E; Korolczuk, A; Madro, A; Prozorow-Król, B; Słomka, M | 1 |
| Awad, AS; Huang, L; Li, L; Linden, J; Lobo, PI; McDuffie, M; Okusa, MD; Sevigny, CP | 1 |
| Albasanz, JL; Castillo, CA; Fernández, M; Martín, M | 1 |
| Bradding, P; Brightling, CE; Cruse, G; Duffy, SM | 1 |
| Hurley, DJ; Moore, JN; Murray, TF; Sun, WC; Vandenplas, ML | 1 |
| Fathollahi, Y; Hosseinmardi, N; Mirnajafi-Zadeh, J; Shahabi, P | 1 |
| Canas, PM; Cunha, RA; Oliveira, CR; Porciúncula, LO; Silva, CG | 1 |
| Hofmann, PA; Ledent, C; Morrison, RR; Mustafa, SJ; Tan, XL | 1 |
| Hamano, R; Iwagaki, H; Kanke, T; Liu, K; Nishibori, M; Sendo, T; Takahashi, HK; Tanaka, N; Yoshino, T | 1 |
| Fathollahi, Y; Mirnajafi-Zadeh, J; Palizvan, MR; Rezvani, ME | 1 |
| Baranyi, M; Illes, P; Sperlágh, B; Vizi, ES; Zsilla, G | 1 |
| Belcastro, V; Borsini, F; Calabresi, P; Centonze, D; Costa, C; Picconi, B; Tantucci, M; Tozzi, A; Tscherter, A | 1 |
| Cao, Z; Hurley, DJ; Linden, J; Moore, JN; Murray, TF; Sun, WC; Vandenplas, ML | 1 |
| Armida, M; Chen, JF; Domenici, MR; Grò, C; Martire, A; Pepponi, R; Popoli, P; Potenza, RL; Schwarzschild, MA; Tebano, MT | 1 |
| Awad, AS; Linden, J; Liu, L; Okusa, MD; Rosin, DL; Rouse, M; Sedor, JR; Vergis, AL | 1 |
| Albasanz, JL; Barrachina, M; Ferrer, I; Martín, M; Perez, S | 1 |
| Binfaré, RW; Budni, J; Lobato, KR; Rodrigues, AL; Rosa, AO; Santos, AR | 1 |
| Coskun, C; Mutlu, D; Savci, V; Suzer, O; Yalcin, M; Yilmaz, MS | 1 |
| Blackburn, MR; Chan, ES; Chiriboga, L; Cronstein, BN; Fernández, P; Trzaska, S; Wilder, T | 1 |
| Chen, JF; Kulik, T; Kung, D; Kusano, Y; Miekisiak, G; Winn, HR | 1 |
| Broadley, KJ; Smith, N | 1 |
| Casanello, P; Escudero, C; Sobrevia, L | 1 |
| Cormack, LK; Feinberg, LM; Schallert, K; Schallert, T; Spinetta, MJ; Stroud, C; Woodlee, MT | 1 |
| Cherezov, V; Chien, EY; Griffith, MT; Hanson, MA; Ijzerman, AP; Jaakola, VP; Lane, JR; Stevens, RC | 1 |
| Bendor, J; Flajolet, M; Futter, M; Greengard, P; Nairn, AC; Nuangchamnong, N; Shen, W; Surmeier, DJ; Wallach, I; Wang, Z | 1 |
| Hamilton, JB; Lancaster, DM; Patel, N; Pietersen, AN; Vreugdenhil, M | 1 |
| Fathollahi, Y; Jahanshahi, A; Javan, M; Mirnajafi-Zadeh, J; Mohammad-Zadeh, M; Motamedi, F; Noorbakhsh, SM | 1 |
| Ahlawat, R; Chavez-Valdez, R; Cristofalo, EA; Gauda, EB; Nathan, A; Wills-Karp, M | 1 |
| Carlström, M; Lai, EY; Patzak, A; Persson, AE | 1 |
| Baghdoyan, HA; Lydic, R; Van Dort, CJ | 1 |
| Ichinose, TK; O'Leary, DS; Scislo, TJ | 1 |
| Fernandes, D; Pamplona, FA; Pandolfo, P; Pires, VA; Prediger, RD; Takahashi, RN | 1 |
| Miriel, VA; Rivers, RJ; Thengchaisri, N | 1 |
| Church, JE; Coupar, IM; Pouton, CW; Rose'Meyer, RB; Urmaliya, VB; White, PJ | 1 |
| Jin, M; Koizumi, S; Linden, J; Odashima, M; Ohnishi, H; Otaka, M; Watanabe, S | 1 |
| Dziubina, A; Gołembiowska, K; Kamińska, K; Kowalska, M | 1 |
| Autuori, A; Belcastro, V; Borsini, F; Calabresi, P; Costa, C; Di Filippo, M; Luchetti, E; Picconi, B; Siliquini, S; Tantucci, M; Tozzi, A | 1 |
| Cipriani, S; Galli, A; Gianfriddo, M; Giovannini, MG; Mello, T; Pedata, F; Pugliese, AM; Traini, C | 1 |
| Bertram, EH; Hargus, NJ; Patel, MK | 1 |
| Abola, E; Brooks, CL; Dixon, JS; Michino, M; Moult, J; Stevens, RC | 1 |
| Csóka, B; Haskó, G; Leibovich, SJ; Lukashev, D; Luo, W; Ramanathan, M; Sitkovsky, MV | 1 |
| Ackerman, Z; Avraham, Y; Berry, EM; Magen, I; Mechoulam, R; Vorobiev, L | 1 |
| Ferrante, A; Ferretti, R; Martire, A; Pepponi, R; Popoli, P | 1 |
| Chen, JF; Chiodi, V; Domenici, MR; Ferrante, A; Frank, C; Ledent, C; Martire, A; Pepponi, R; Popoli, P; Tebano, MT | 1 |
| Borea, PA; Catarzi, D; Colotta, V; Filacchioni, G; Lenzi, O; Morizzo, E; Moro, S; Paoletta, S; Poli, D; Varani, K; Varano, F; Vincenzi, F | 1 |
| Maass, A; Müller, CE; Schiedel, AC; Sherbiny, FF | 1 |
| Carroll, MA; Doumad, AB; Falck, JR; Li, J; Liclican, EL; Stier, CT; Wang, J | 1 |
| Bernstein, SH; Burack, WR; Cochran, MR; Hilchey, SP; Hyrien, O; Kobie, JJ; Mosmann, TR; Quataert, SA; Secor-Socha, S; Wang, JC | 1 |
| Aronhime, SN; Chen, JF; Echeverry, G; Kulik, TB; Kusano, Y; Miekisiak, G; Winn, HR | 1 |
| Albasanz, JL; Barrachina, M; Buira, SP; Dentesano, G; Ferrer, I; Martín, M; Moreno, J | 1 |
| Boeck, CR; Calo', G; de Castro, AA; Dos Santos Casagrande, T; Gavioli, EC; Guerrini, R; Martinello, C; Moretti, M | 1 |
| Berghaus, LJ; Hurley, DJ; Linden, J; Moore, JN; Sun, WC; Thompson, R; Vandenplas, ML | 1 |
| Abrol, R; Goddard, WA; Griffith, AR; Kim, SK; Li, Y; Trzaskowski, B | 1 |
| Chen, SR; Li, DP; Pan, HL | 1 |
| Arnould, I; Bellamy, JF; Besnard, F; Blouquit-Laye, S; Buenestado, A; Chapelier, A; Devillier, P; Grassin Delyle, S; Naline, E | 1 |
| Cairo, G; Gammella, E; Tacchini, L | 1 |
| Ijzerman, AP; Jaakola, VP; Katritch, V; Lane, JR; Lin, JY; Stevens, RC | 1 |
| Ledent, C; Palmer, TM; Rutherford, C; Safhi, MM; Sands, WA | 1 |
| Belcher, JD; Geng, JG; Huo, Y; Slungaard, A; Tang, R; Viollet, B; Wang, H; Wang, J; Wu, C; Zhang, C; Zhang, W; Zhu, C | 1 |
| Pao, AC; Rajagopal, M | 1 |
| Carlström, M; Welch, WJ; Wilcox, CS | 1 |
| Ashok, Y; Jaakola, VP; Nanekar, RT; Piirainen, H | 1 |
| Li, GQ; Lu, HH; Mo, Q; Qian, J; Tang, LM; Wang, F; Wang, XH; Zhu, J; Zhu, JF | 1 |
| Fredholm, BB; Hao, JX; Li, L; Schulte, G; Wiesenfeld-Hallin, Z; Xu, XJ | 1 |
| Ledent, C; Pouton, CW; Short, JL; Urmaliya, VB; White, PJ | 1 |
| Beukers, MW; Guo, D; Ijzerman, AP; Müller, CE; Peeters, MC; van Westen, GJ; Wisse, LE | 1 |
| Che, PL; Du, J; Ha, B; Wang, Z; Yarema, KJ | 1 |
| Casadó, V; Cinca, J; Ciruela, F; Fernandes, J; Franco, R; Hove-Madsen, L; Llach, A; Lluís, C; Molina, CE; Prat-Vidal, C | 1 |
| Alves-Do-Prado, W; Bornia, EC; Correia-de-Sá, P | 1 |
| Carlini, M; Cesari, D; Da Pozzo, E; Daniele, S; Dell'Osso, L; Golia, F; Martini, C; Panighini, A; Picchetti, M; Trincavelli, ML | 1 |
| Cherezov, V; Gao, ZG; Han, GW; Jacobson, KA; Katritch, V; Stevens, RC; Wu, H; Xu, F | 1 |
| Chen, JF; Feng, L; Garcia, GE; Johnson, RJ; Truong, LD | 1 |
| Choukèr, A; Feuerecker, M; Kaufmann, I; Salam, A; Schelling, G; Thiel, M | 1 |
| Bennett, K; Edwards, PC; Langmead, CJ; Lebon, G; Leslie, AG; Tate, CG; Warne, T | 1 |
| Andrews, SP; Congreve, M; Errey, JC; Marshall, FH; Mason, JS; Robertson, N; Tehan, B; Weir, M; Zhukov, A | 1 |
| Cronstein, BN; Williams, AJ | 1 |
| Brown, RM; Duncan, JR; Lawrence, AJ; Ledent, C; Stagnitti, MR | 1 |
| Bennett, K; Congreve, M; Doré, AS; Errey, JC; Hollenstein, K; Hurrell, E; Magnani, F; Marshall, FH; Ng, I; Robertson, N; Tate, CG; Tehan, B; Weir, M | 1 |
| Ayers, PW; Burger, SK; Liu, Y; Vöhringer-Martinez, E | 1 |
| Moriya, T; Nakahata, N; Nakata, H; Obara, Y; Suzuki, T | 1 |
| Akamine, AT; Almeida, VI; Crippa, JA; Dal-Pizzol, F; Ferraz-de-Paula, V; Hallak, JE; Mariano-Souza, DP; Palermo-Neto, J; Pinheiro, ML; Quevedo, J; Quinteiro-Filho, WM; Ribeiro, A; Vitoretti, LB; Zuardi, AW | 1 |
| Chancellor, MB; de Groat, WC; Kitta, T; Kuno, S; Nonomura, K; Yoshimura, N | 1 |
| Dell'anno, MT; Fisone, G; Pallottino, S | 1 |
| Chen, X; Kang, H; Li, X; Liu, X; Liu, Z; Shu, K; Zhu, S | 1 |
| Blanco, C; Colettis, N; Hartley, RC; Harvey, AL; Jamieson, AG; Jerusalinsky, D; Kornisiuk, E; Snitcofsky, M; Stone, TW; Young, LC | 1 |
| Chiriboga, L; Cronstein, BN; Perez-Aso, M | 1 |
| Lochner, A; Moolman, JA; Salie, R | 1 |
| Cherezov, V; Chubukov, P; Chun, E; Han, GW; Heitman, LH; IJzerman, AP; Katritch, V; Liu, W; Roth, CB; Stevens, RC; Thompson, AA; Xu, F | 1 |
| Azevedo, MS; Cechinel-Filho, V; Ferreira, VM; Lucena, GM; Matheus, FC; Prediger, RD; Tessele, PB | 1 |
| Falck, JR; Morisseau, C; Mustafa, SJ; Nayeem, MA; Pradhan, I; Zeldin, DC | 1 |
| Coppi, E; Galli, A; Maraula, G; Mello, T; Pedata, F; Pugliese, AM; Traini, C | 1 |
| Martins, DF; Mazzardo-Martins, L; Piovezan, AP; Santos, AR; Soldi, F; Stramosk, J | 1 |
| Ashok, Y; Jaakola, VP; Nanekar, RT | 1 |
| Ailawadi, G; Barbery, C; Bhamidipati, CM; Kron, IL; Laubach, VE; Meher, AK; Mehta, GS; Moehle, CW; Owens, GK; Sharma, AK; Su, G; Upchurch, GR; Vigneshwar, NG | 1 |
| Adams, C; Choi, DS; Hinton, DJ; Kang, NY; Kim, T; Lee, MR; Nam, HW; Oliveros, A; Ruby, CL | 1 |
| An, JH; Chen, JF; Dai, SS; Li, W; Ning, YL; Wang, H; Yang, N; Zhou, YG; Zhu, PF | 1 |
| Han, K; Pang, X; Yang, M | 1 |
| Almerico, AM; Lauria, A; Pantano, L; Tutone, M | 1 |
| Capuano, B; Jörg, M; Mak, FS; Miller, ND; Scammells, PJ; Shonberg, J; Yuriev, E | 1 |
| Alam, MN; Hsieh, KC; Kumar, S; McGinty, D; Rai, S; Szymusiak, R | 1 |
| Agostinho, P; Castro, AA; Cunha, RA; Garção, P; Köfalvi, A; Prediger, RD; Szabó, EC; Tomé, ÂR; Wopereis, S | 1 |
| Bacilieri, M; Cacciari, B; Ciancetta, A; Cosconati, S; Da Settimo, F; Federico, S; Klotz, KN; Moro, S; Novellino, E; Paoletta, S; Spalluto, G; Taliani, S | 1 |
| Carrillo-Salinas, FJ; Feliú, A; Guaza, C; Iñigo, PM; Mecha, M; Mestre, L | 1 |
| Antonia, SJ; Khalil, FK; Luddy, K; Mediavilla-Varela, M; Neuger, AM; Noyes, D; Soliman, H | 1 |
| Feng, LY; Huang, L; Wu, DD; Zhang, L | 1 |
| Bencivelli, D; Borea, PA; Casetta, I; Corciulo, C; Gentile, M; Granieri, E; Varani, K; Vincenzi, F | 1 |
| Bernardo, A; De Nuccio, C; Ferrante, A; Minghetti, L; Pepponi, R; Popoli, P; Visentin, S | 1 |
| Minic, Z; O'Leary, DS; Scislo, TJ | 1 |
| Alves-Do-Prado, W; Ambiel, CR; Antônio, MB; Correia-de-Sá, P; de Paula Ramos, E | 1 |
| Alarcón, M; Badimon, L; Caballero, J; Fuentes, E; Padró, T; Palomo, I; Pérez, P; Vilahur, G | 1 |
| Frøbert, O; Hedegaard, ER; Mogensen, S; Nielsen, BD; Rembold, CM; Simonsen, U | 1 |
| Albasanz, JL; Barrachina, M; Blanch, M; Díaz-Sánchez, S; Ferrer, I; Martín, M; Monje, A; Pereira-Veiga, T; Planchat, LM; Villar-Menéndez, I | 1 |
| Exley, M; Kini, R; Madasu, M; Nowak, M; Ohta, A; Sitkovsky, M; Subramanian, M | 1 |
| Bruzzese, L; By, Y; Condo, J; Durand-Gorde, JM; Fenouillet, E; Fromonot, J; Guieu, R; Kipson, N; Ruf, J | 1 |
| Brussee, J; Guo, D; Hazeu, M; Heitman, LH; Ijzerman, AP; Mocking, T; van Veldhoven, JP; Xia, L | 1 |
| Alarcón, M; Caballero, J; Fuentes, E; Palomo, I; Rojas, A | 1 |
| Lappas, CM | 1 |
| Arias-Montaño, JA; Escamilla-Sánchez, J; González-Pantoja, R; Márquez-Gómez, R; Morales-Figueroa, GE | 1 |
| Liu, W; Manaenko, A; Sun, X; Ye, Z; Zhang, L; Zhang, R | 1 |
| Dimitrieva, TV; Pliyev, BK; Savchenko, VG | 1 |
| Åqvist, J; Gutiérrez-de-Terán, H; Keränen, H | 1 |
| Cataño-Cañizalez, YG; Cortés-Garcia, JD; Cortez-Espinosa, N; Guzman-Flores, JM; Portales-Perez, DP; Rodríguez-Rivera, JG; Vargas-Morales, JM | 1 |
| Bilos, A; Geraci, S; Gretz, N; Heemskerk, S; Kraenzlin, B; Masereeuw, R; Peters, E; Pickkers, P; Wilmer, MJ | 1 |
| Chaimovitz, C; Douvdevani, A; Eini, H; Frishman, V; Kachko, L; Lewis, EC; Yulzari, R | 1 |
| Cortés-Garcia, JD; Cortez-Espinosa, N; García-Hernández, MH; Guzmán-Flores, JM; Layseca-Espinosa, E; López-López, C; Portales-Cervantes, L; Portales-Pérez, DP | 1 |
| Kimura, E; Matsuno, A; Midorikawa, T; Monoi, N; Murakoshi, M; Nagamori, Y; Nakamura, Y; Nishino, H; Oka, K; Sano, T; Sugafuji, T; Sugiyama, K; Uchiyama, A; Urade, Y | 1 |
| Cronstein, BN; Levine, J; Low, YC; Mediero, A; Perez-Aso, M | 1 |
| Guo, D; Hankemeier, T; Hölscher, A; Holzheimer, M; IJzerman, AP; Louvel, J; Massink, A; Spijksma, G | 1 |
| Cai, L; Luo, HM; Pi, T; Ren, XM; Su, CF; Wu, WT; Zhang, W; Zhou, XW | 1 |
| Sabio, M; Topiol, S | 1 |
| Christopoulos, A; Gregory, KJ; May, LT; Tan, CY; Vecchio, EA; White, PJ | 1 |
| Dror, RO; Guo, D; Heitman, LH; IJzerman, AP; Liu, R; Mocking, T; Pan, AC; Shaw, DE | 1 |
| Huang, P; Huang, S; Liu, X; Luo, X; Qi, J; Shen, X; Wang, J; Yang, Z; Zhong, Y | 1 |
| Bortolato, A; Cheng, RK; Cooke, RM; Deflorian, F; Doré, AS; Errey, JC; Guo, D; Heitman, LH; IJzerman, AP; Marshall, FH; Segala, E | 1 |
| Bethge, P; Blanchet, C; Cunha, RA; Frick, A; Gonçalves, FQ; Gonçalves, N; Gorlewicz, A; Grosjean, N; Haberl, MG; Lemos, C; Malezieux, M; Mulle, C; Nägerl, UV; Viana da Silva, S; Zhang, P | 1 |
| Kimura, E; Midorikawa, T; Monoi, N; Murakoshi, M; Murata-Matsuno, A; Nakamura, Y; Nishino, H; Oka, K; Sano, T; Sugafuji, T; Sugiyama, K; Uchiyama, A; Urade, Y | 1 |
| Amin, MN; Chiang, MJ; Cole, PA; Gabrielson, K; Giddens, J; Hsiao, PY; Kalin, JH; Lo, YC; Powell, JD; Sun, IH; Sysa-Shah, P; Wang, LX | 1 |
| Bonaventura, J; Brugarolas, M; Casadó, V; Cellai, L; Chang, CP; Chern, Y; Cortés, A; Dettori, I; Ferré, S; Guitart, X; Narayanan, M; Orrú, M; Pedata, F; Rea, W | 1 |
| Adam, RM; Chung, YG; Cristofaro, V; Doyle, C; Lukianov, SN; Sack, BS; Schäfer, M; Sullivan, MP | 1 |
| Bai, W; Chen, JF; Chen, X; Chen, XY; Li, P; Liu, D; Ning, YL; Peng, Y; Wang, H; Yang, N; Zhao, Y; Zhao, ZA; Zhou, YG | 1 |
| Colmenero, AV; Gabel, M; Hambrecht-Wiedbusch, VS; Imperial, JP; Liu, LJ; Vanini, G | 1 |
| Guo, D; IJzerman, AP | 1 |
| Chen, JF; Li, P; Ning, YL; Peng, Y; Yang, N; Zeng, XJ; Zhao, Y; Zhao, ZA; Zhou, YG | 1 |
| Ernst, OP; García, AE; Larda, ST; Lyda, B; Neale, C; Pichugin, D; Pomès, R; Prosser, RS; Sljoka, A; Sunahara, RK; Tsuchimura, N; Ye, L | 1 |
| Bajnok, A; Orbán, C; Sava, F; Toldi, G; Vásárhelyi, Z | 1 |
| Ávila-Ibarra, LR; de Lourdes Mora-García, M; Del Carmen Fuentes-Castañeda, M; Don-López, CA; García-Rocha, R; Gutiérrez-Serrano, V; Hernández-Montes, J; Monroy-García, A; Torres-Pineda, DB; Weiss-Steider, B | 1 |
| Cao, J; Dong, Z; Li, W; Lin, H; Shi, Y; Xiao, R; Zhang, X | 1 |
| Chelvanambi, M; Fabian, KPL; Hong, CS; Lang, S; Ludwig, S; Razzo, BM; Storkus, WJ; Whiteside, TL | 1 |
| Dziodzio, J; Eldridge, A; Emery, IF; Ichinose, F; Leclerc, A; Lord, C; Lucas, FL; May, T; McCrum, B; Riker, R; Robich, MP; Ryzhov, S; Sawyer, DB; Seder, DB | 1 |
| Conde, SV; Gonzalez, C; Martins, FO; Melo, BF; Monteiro, EC; Olea, E; Prieto-Lloret, J; Ribeiro, MJ; Sacramento, JF | 1 |
| Baudry, JY; Green, AT; Hu, X; Humphreys, BM; Parks, JM; Smith, JC; Smith, MD | 1 |
| Bill, RM; Dafforn, TR; Jamshad, M; Lin, YP; Little, HA; Poyner, DR; Routledge, SJ; Simms, J; Spickett, CM; Thakker, A; Wheatley, M | 1 |
| Byeon, JJ; Choi, JM; Kim, N; Lee, BI; Lim, JH; Na, YG; Park, MH; Park, MJ; Park, SJ; Park, Y; Shin, SH; Shin, YG | 1 |
| Buccioni, M; Coelho, JE; Dal Ben, D; Lambertucci, C; Lopes, LV; Marques-Morgado, I; Martí Navia, A; Marucci, G; Spinaci, A; Volpini, R | 1 |
| Dong, X; Fan, Y; Li, L; Liu, X; Lu, Q; Sun, B; Yang, Y; Zhang, H; Zhao, J; Zhu, J | 1 |
| Briddon, SJ; Franks, HA; Harwood, CR; Hill, SJ; Kellam, B; Kindon, ND; Otun, O; Patera, F; Stoddart, LA; Veprintsev, DB; Woolard, J | 1 |
3 review(s) available for triazoles and zm 241385
| Article | Year |
|---|---|
Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008.
Topics: Animals; Crystallization; Crystallography, X-Ray; Drug Design; Drug Industry; Humans; Ligands; Models, Molecular; Predictive Value of Tests; Protein Binding; Receptor, Adenosine A2A; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Triazines; Triazoles | 2009 |
Structural features of adenosine receptors: from crystal to function.
Topics: Crystallography, X-Ray; Humans; Protein Conformation; Receptors, Purinergic P1; Triazines; Triazoles | 2011 |
Molecular Basis of Ligand Dissociation from G Protein-Coupled Receptors and Predicting Residence Time.
Topics: Cholinergic Antagonists; Drug Discovery; Humans; Kinetics; Ligands; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Binding; Quantitative Structure-Activity Relationship; Receptors, Cholinergic; Receptors, G-Protein-Coupled; Receptors, Purinergic P1; Tiotropium Bromide; Triazines; Triazoles | 2018 |
3 trial(s) available for triazoles and zm 241385
| Article | Year |
|---|---|
Effects of doxazosin and propranolol on A2A adenosine receptors in essential hypertension.
Topics: Adenosine-5'-(N-ethylcarboxamide); Adult; Antihypertensive Agents; Binding, Competitive; Blood Pressure; Body Mass Index; Cyclic AMP; Diastole; Doxazosin; Female; Humans; Hypertension; Lymphocytes; Male; Middle Aged; Neutrophils; Propranolol; Radioligand Assay; Receptor, Adenosine A2A; Receptors, Purinergic P1; Reference Values; Systole; Treatment Outcome; Triazines; Triazoles | 2002 |
Plasma glutamate-modulated interaction of A2AR and mGluR5 on BMDCs aggravates traumatic brain injury-induced acute lung injury.
Topics: Acute Lung Injury; Adenosine; Adenosine A2 Receptor Agonists; Adult; Animals; Bone Marrow Cells; Brain Injuries; Disease Models, Animal; Female; Glutamic Acid; Humans; Male; Mice; Mice, Knockout; Middle Aged; Phenethylamines; Protein Kinase C; Receptor, Adenosine A2A; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Signal Transduction; Triazines; Triazoles; Type C Phospholipases | 2013 |
Japanese sake yeast supplementation improves the quality of sleep: a double-blind randomised controlled clinical trial.
Topics: Adenosine A2 Receptor Antagonists; Adult; Alcoholic Beverages; Cell Extracts; Cross-Over Studies; Double-Blind Method; Electroencephalography; Female; HEK293 Cells; Humans; Male; Powders; Receptor, Adenosine A2A; Saccharomyces cerevisiae; Sleep; Sleep Stages; Triazines; Triazoles | 2016 |
341 other study(ies) available for triazoles and zm 241385
| Article | Year |
|---|---|
In vivo characterisation of ZM 241385, a selective adenosine A2A receptor antagonist.
Topics: Adenosine; Animals; Cardiovascular Agents; Decerebrate State; Dogs; Female; Heart Rate; Hindlimb; In Vitro Techniques; Myocardial Contraction; Purinergic P1 Receptor Antagonists; Rats; Rats, Inbred SHR; Regional Blood Flow; Triazines; Triazoles; Vasodilation | 1996 |
Activation of multiple sites by adenosine analogues in the rat isolated aorta.
Topics: Adenosine; Animals; Aorta, Thoracic; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Rats; Rats, Wistar; Receptors, Purinergic P1; Sulfonamides; Theophylline; Triazines; Triazoles; Xanthines | 1996 |
Pharmacodynamics of ZM 241385, a potent A2a adenosine receptor antagonist, after enteric administration in rat, cat and dog.
Topics: Administration, Oral; Animals; Cats; Dogs; Drug Interactions; Female; Hemodynamics; Hypertension; Injections, Intravenous; Intubation, Gastrointestinal; Male; Purinergic P1 Receptor Antagonists; Rats; Species Specificity; Theophylline; Triazines; Triazoles; Vasodilation; Vasodilator Agents | 1996 |
125I-4-(2-[7-amino-2-[2-furyl][1,2,4]triazolo[2,3-a][1,3,5] triazin-5-yl-amino]ethyl)phenol, a high affinity antagonist radioligand selective for the A2a adenosine receptor.
Topics: Animals; Cattle; CHO Cells; Cricetinae; Iodine Radioisotopes; Purinergic P1 Receptor Antagonists; Radioligand Assay; Receptors, Purinergic P1; Recombinant Proteins; Triazines; Triazoles | 1995 |
The role of the A(2A) adenosine receptor subtype in functional hyperaemia in the hindlimb of anaesthetized cats.
Topics: Adenosine; Animals; Arteries; Cats; Gases; Hindlimb; Hydrogen-Ion Concentration; Hyperemia; Isometric Contraction; Male; Muscles; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Regional Blood Flow; Theophylline; Triazines; Triazoles | 1996 |
Ischaemic skeletal muscle hyperaemia in the anaesthetized cat: no contribution of A2A adenosine receptors.
Topics: Anesthesia, General; Animals; Blood Pressure; Cats; Electric Stimulation; Femoral Nerve; Hindlimb; Hyperemia; Ischemia; Isometric Contraction; Male; Muscle Contraction; Muscle, Skeletal; Oxygen Consumption; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A2A; Receptors, Purinergic P1; Regional Blood Flow; Sciatic Nerve; Triazines; Triazoles | 1997 |
Adenosine analogues relax guinea-pig taenia caeci via an adenosine A2B receptor and a xanthine-resistant site.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cecum; Dose-Response Relationship, Drug; Guinea Pigs; Male; Muscle Relaxation; Muscle, Smooth; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Theophylline; Triazines; Triazoles; Vasodilator Agents; Xanthines | 1997 |
Desensitisation of the adenosine A1 receptor by the A2A receptor in the rat striatum.
Topics: Adenosine; Animals; Antihypertensive Agents; Corpus Striatum; Enzyme Inhibitors; Isoquinolines; Phenethylamines; Presynaptic Terminals; Protein Kinase C; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; Sensitivity and Specificity; Sulfonamides; Synaptosomes; Triazines; Triazoles; Tritium; Xanthines | 1997 |
Memory of extracellular adenosine A2A purinergic receptor-mediated signaling in murine T cells.
Topics: Adenosine; Animals; Cell Division; Exocytosis; Extracellular Matrix; Fas Ligand Protein; fas Receptor; Interleukin-2; Membrane Glycoproteins; Mice; Mice, Inbred DBA; Phenethylamines; Purinergic P1 Receptor Agonists; Receptor, Adenosine A2A; Receptors, Antigen, T-Cell; Receptors, Purinergic P1; Signal Transduction; T-Lymphocytes; Triazines; Triazoles | 1997 |
ZM241385 is an antagonist of the facilitatory responses produced by the A2A adenosine receptor agonists CGS21680 and HENECA in the rat hippocampus.
Topics: Acetylcholine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Antihypertensive Agents; Binding Sites; Hippocampus; Ligands; Membranes; Phenethylamines; Platelet Aggregation Inhibitors; Purinergic P1 Receptor Agonists; Rats; Synaptic Transmission; Synaptosomes; Triazines; Triazoles; Visual Cortex | 1997 |
Activation of two sites by adenosine receptor agonists to cause relaxation in rat isolated mesenteric artery.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Anti-Arrhythmia Agents; Dinucleoside Phosphates; Dose-Response Relationship, Drug; Male; Mesenteric Arteries; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles; Vasodilation; Vasodilator Agents | 1997 |
Adenosine A1 receptor-mediated activation of AMP-activated protein kinase in bovine bronchial rings.
Topics: Adenosine-5'-(N-ethylcarboxamide); Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Bronchi; Cattle; Enzyme Activation; In Vitro Techniques; Multienzyme Complexes; Phenylisopropyladenosine; Protein Kinases; Protein Serine-Threonine Kinases; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Ribonucleotides; Triazines; Triazoles; Xanthines | 1997 |
Inhibitory effect of adenosine on degranulation of human cultured mast cells upon cross-linking of Fc epsilon RI.
Topics: Adenosine; Antibodies; Chymases; Cross-Linking Reagents; Cyclic AMP; Guanosine; Humans; Immunoglobulin E; Mast Cells; Mitogen-Activated Protein Kinase 1; Phenethylamines; Phosphorylation; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, IgE; RNA, Messenger; Serine Endopeptidases; Thioinosine; Thionucleosides; Triazines; Triazoles; Tryptases | 1998 |
Adenosine modulates hypoxia-induced responses in rat PC12 cells via the A2A receptor.
Topics: Adenosine; Adenosine Deaminase; Adrenal Gland Neoplasms; Animals; Calcium; Cell Hypoxia; Fluorescent Dyes; Fura-2; Lung; Membrane Potentials; Patch-Clamp Techniques; PC12 Cells; Pheochromocytoma; Purinergic P1 Receptor Antagonists; Rats; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptor, Adenosine A3; Receptors, Purinergic P1; RNA, Messenger; Theophylline; Transcription, Genetic; Triazines; Triazoles | 1998 |
Role of adenosine and its receptors in the vasodilatation induced in the cerebral cortex of the rat by systemic hypoxia.
Topics: Adenosine; Animals; Blood Flow Velocity; Blood-Brain Barrier; Erythrocytes; Hypoxia; Laser-Doppler Flowmetry; Male; Parietal Lobe; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles; Vasodilation | 1998 |
Protection against kainate-induced excitotoxicity by adenosine A2A receptor agonists and antagonists.
Topics: Adenosine; Animals; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Neurons; Neuroprotective Agents; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Triazines; Triazoles; Xanthines | 1998 |
Protection against hippocampal kainate excitotoxicity by intracerebral administration of an adenosine A2A receptor antagonist.
Topics: Adenosine; Adrenergic alpha-2 Receptor Antagonists; Animals; Antihypertensive Agents; Brain Chemistry; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Neurotoxins; Phenethylamines; Rats; Rats, Wistar; Triazines; Triazoles | 1998 |
Binding affinity of adenosine receptor agonists and antagonists at human cloned A3 adenosine receptors.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Binding, Competitive; Cell Line; Cloning, Molecular; Humans; Kidney; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Quinazolines; Receptor, Adenosine A3; Receptors, Purinergic P1; Transfection; Triazines; Triazoles | 1998 |
A2A-adenosine receptor reserve for coronary vasodilation.
Topics: Adenosine; Animals; Coronary Circulation; Female; Guinea Pigs; Heart; In Vitro Techniques; Kinetics; Male; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Triazines; Triazoles; Vasodilation | 1998 |
The role of adenosine in rat coronary flow regulation during respiratory and metabolic acidosis.
Topics: Acidosis; Acidosis, Respiratory; Adenosine; Animals; Caffeine; Coronary Circulation; Hypercapnia; Male; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Sprague-Dawley; Theophylline; Triazines; Triazoles | 1998 |
Adenosine receptor subtypes and vasodilatation in rat skeletal muscle during systemic hypoxia: a role for A1 receptors.
Topics: Adenosine; Animals; Antihypertensive Agents; Blood Gas Analysis; Hydrogen-Ion Concentration; Hypoxia; Male; Muscle, Skeletal; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Regional Blood Flow; Respiration; Triazines; Triazoles; Vasodilation; Vasodilator Agents; Xanthines | 1999 |
Interaction between adenosine A1 and A2 receptor-mediated responses in the rat hippocampus in vitro.
Topics: Adenosine; Animals; Excitatory Postsynaptic Potentials; Hippocampus; Male; Organ Culture Techniques; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrazines; Rats; Rats, Wistar; Receptors, Purinergic P1; Triazines; Triazoles | 1998 |
Adenosine A2a receptors increase arterial endothelial cell nitric oxide.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Carotid Arteries; Cells, Cultured; Endothelium, Vascular; Humans; Iliac Artery; Nitric Oxide; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Swine; Triazines; Triazoles; Xanthines | 1998 |
Comparison of CGS 15943, ZM 241385 and SCH 58261 as antagonists at human adenosine receptors.
Topics: Animals; Cell Line; CHO Cells; Cricetinae; Cyclic AMP; Humans; Purinergic P1 Receptor Antagonists; Pyrimidines; Quinazolines; Rats; Transfection; Triazines; Triazoles; Xanthines | 1999 |
Adenosine A1 receptor-mediated antiadrenergic effects are modulated by A2a receptor activation in rat heart.
Topics: Adenosine; Adrenergic alpha-Antagonists; Animals; Calcium; Drug Synergism; Heart; In Vitro Techniques; Intracellular Membranes; Male; Myocardium; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Triazines; Triazoles | 1999 |
Sensitization by chronic diazepam treatment of A2A adenosine receptor-mediated relaxation in rat pulmonary artery.
Topics: Adenosine; Animals; Carrier Proteins; Diazepam; Dinucleoside Phosphates; Dipyridamole; Dose-Response Relationship, Drug; Female; Heart; Heart Atria; Muscle Relaxation; Phenethylamines; Pulmonary Artery; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; Thioinosine; Triazines; Triazoles; Verapamil | 1999 |
G protein coupling of CGS 21680 binding sites in the rat hippocampus and cortex is different from that of adenosine A1 and striatal A2A receptors.
Topics: Adenosine; Animals; Binding Sites; Binding, Competitive; Brain; Cerebral Cortex; Cholera Toxin; Corpus Striatum; Ethylmaleimide; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Hippocampus; Male; Membranes; Pertussis Toxin; Phenethylamines; Purinergic P1 Receptor Agonists; Pyrimidines; Rats; Rats, Wistar; Receptors, Purinergic P1; Triazines; Triazoles; Tritium; Virulence Factors, Bordetella | 1999 |
Selective A2A adenosine receptor activation reduces ischemia-reperfusion injury in rat kidney.
Topics: Animals; Humans; Kidney; Male; Necrosis; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Reperfusion Injury; Triazines; Triazoles | 1999 |
Increase in the number, G protein coupling, and efficiency of facilitatory adenosine A2A receptors in the limbic cortex, but not striatum, of aged rats.
Topics: Adenosine; Aging; Animals; Cell Membrane; Cerebral Cortex; Corpus Striatum; Cyclic AMP; Dentate Gyrus; GTP-Binding Proteins; Kinetics; Limbic System; Male; Organ Specificity; Phenethylamines; Purinergic P1 Receptor Agonists; Radioligand Assay; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; Triazines; Triazoles; Tritium | 1999 |
Autoradiographic comparison of the potency of several structurally unrelated adenosine receptor antagonists at adenosine A1 and A(2A) receptors.
Topics: Adenosine; Animals; Autoradiography; Binding, Competitive; Brain; Caffeine; In Vitro Techniques; Male; Phenethylamines; Purinergic P1 Receptor Antagonists; Pyrazines; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles; Tritium; Xanthines | 1999 |
Neutrophil A2A adenosine receptor inhibits inflammation in a rat model of meningitis: synergy with the type IV phosphodiesterase inhibitor, rolipram.
Topics: Adenosine; Animals; Blood-Brain Barrier; Cell Adhesion; Cyclic AMP; Disease Models, Animal; Drug Synergism; Humans; Leukocytosis; Meningitis, Bacterial; Neutrophil Activation; Neutrophils; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; Respiratory Burst; Rolipram; Superoxides; Triazines; Triazoles; Tumor Necrosis Factor-alpha | 1999 |
Selective reduction in A2 adenosine receptor desensitization following antisense-induced suppression of G protein-coupled receptor kinase 2 expression.
Topics: Animals; beta-Adrenergic Receptor Kinases; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA, Antisense; G-Protein-Coupled Receptor Kinase 2; G-Protein-Coupled Receptor Kinase 3; Gene Expression; Glioma; Homeostasis; Hybrid Cells; Mice; Neuroblastoma; Phosphorylation; Rats; Receptors, Purinergic P1; Transfection; Triazines; Triazoles; Tumor Cells, Cultured | 1999 |
Stimulation of A(2A) adenosine receptor phosphorylation by protein kinase C activation: evidence for regulation by multiple protein kinase C isoforms.
Topics: Acetophenones; Animals; Benzopyrans; Carbazoles; CHO Cells; Consensus Sequence; Cricetinae; Cyclic AMP; Dogs; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Glioma; Indoles; Isoenzymes; Maleimides; Mutagenesis, Site-Directed; Phosphorylation; Protein Kinase C; Rats; Receptor, Adenosine A2A; Receptors, Purinergic P1; Signal Transduction; Tetradecanoylphorbol Acetate; Triazines; Triazoles; Tumor Cells, Cultured | 1999 |
Effect of A2A adenosine receptor stimulation and antagonism on synaptic depression induced by in vitro ischaemia in rat hippocampal slices.
Topics: Adenosine; Animals; Excitatory Postsynaptic Potentials; Hippocampus; Hypoxia-Ischemia, Brain; In Vitro Techniques; Male; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Synapses; Synaptic Transmission; Triazines; Triazoles; Xanthines | 1999 |
Adenosine inhibits a non-inactivating K+ current in bovine adrenal cortical cells by activation of multiple P1 receptors.
Topics: Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Cattle; GTP-Binding Proteins; In Vitro Techniques; Male; Membrane Potentials; Patch-Clamp Techniques; Potassium; Potassium Channel Blockers; Potassium Channels; Receptors, Purinergic P1; Signal Transduction; Triazines; Triazoles; Xanthines; Zona Fasciculata | 1999 |
Sensitization of visceral afferents to bradykinin in rat jejunum in vitro.
Topics: Adenosine; Animals; Bradykinin; Bucladesine; Cyclooxygenase Inhibitors; Dinoprostone; Histamine; Histamine Antagonists; Histamine H2 Antagonists; In Vitro Techniques; Jejunum; Male; Membrane Potentials; Naproxen; Neurons, Afferent; Piperidines; Ranitidine; Rats; Rats, Inbred Strains; Serotonin; Stimulation, Chemical; Triazines; Triazoles; Xanthines | 1999 |
Increase in the vasorelaxant potency of K(ATP) channel opening drugs by adenosine A(1) and A(2) receptors in the pig coronary artery.
Topics: Adenosine; Animals; ATP-Binding Cassette Transporters; Coronary Vessels; Cromakalim; Dose-Response Relationship, Drug; Drug Interactions; In Vitro Techniques; KATP Channels; Nicorandil; Phenethylamines; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Swine; Triazines; Triazoles; Vasodilator Agents; Xanthines | 1999 |
ZM 241385, an adenosine A(2A) receptor antagonist, inhibits hippocampal A(1) receptor responses.
Topics: Animals; Dinucleoside Phosphates; Enzyme Inhibitors; Hippocampus; Male; Phenylisopropyladenosine; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; Triazines; Triazoles | 1999 |
Afferent arteriolar adenosine A2a receptors are coupled to KATP in in vitro perfused hydronephrotic rat kidney.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Arterioles; Blood Pressure; Enzyme Inhibitors; Hydronephrosis; Kidney; Perfusion; Potassium Channels; Potassium Chloride; Rats; Receptor, Adenosine A2A; Receptors, Purinergic P1; Renal Artery; Renal Circulation; Triazines; Triazoles; Vasoconstriction; Vasodilation; Vasodilator Agents; Xanthines | 1999 |
Cross talk between A(1) and A(2A) adenosine receptors in the hippocampus and cortex of young adult and old rats.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Aging; Animals; Binding, Competitive; Cerebral Cortex; Electrophysiology; Hippocampus; In Vitro Techniques; Male; Phenethylamines; Protein Kinase C; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor Cross-Talk; Receptor, Adenosine A2A; Receptors, Purinergic P1; Synaptic Membranes; Triazines; Triazoles; Xanthines | 1999 |
Use of the triazolotriazine [3H]ZM 241385 as a radioligand at recombinant human A2B adenosine receptors.
Topics: Animals; Cell Line; CHO Cells; Cricetinae; Humans; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Radioligand Assay; Receptor, Adenosine A2B; Receptors, Purinergic P1; Recombinant Proteins; Triazines; Triazoles; Tritium | 1999 |
[Adenosine reduces ischemia/reperfusion-induced liver injury by inhibiting leukocyte activation].
Topics: Adenosine; Alkynes; Animals; Humans; In Vitro Techniques; Leukocyte Elastase; Liver; Male; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Rats; Rats, Wistar; Receptors, Purinergic P1; Reperfusion Injury; Transaminases; Triazines; Triazoles; Tumor Necrosis Factor-alpha | 1999 |
Localization and action of adenosine A2a receptors in regions of the brainstem important in cardiovascular control.
Topics: Adenosine; Animals; Aorta; Autoradiography; Blood Pressure; Brain Stem; Image Processing, Computer-Assisted; Iodine Radioisotopes; Phrenic Nerve; Pressoreceptors; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Reflex; Stimulation, Chemical; Triazines; Triazoles | 2000 |
The anxiogenic-like effect of caffeine in two experimental procedures measuring anxiety in the mouse is not shared by selective A(2A) adenosine receptor antagonists.
Topics: Adenosine; Administration, Oral; Animals; Anxiety; Behavior, Animal; Caffeine; Darkness; Drug Administration Schedule; Injections, Intraperitoneal; Light; Male; Maze Learning; Mice; Mice, Knockout; Neuroprotective Agents; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Reaction Time; Receptor, Adenosine A2A; Triazines; Triazoles; Xanthines | 2000 |
Role of adenosine A(2B) receptors in vasodilation of rat pial artery and cerebral blood flow autoregulation.
Topics: Animals; Arteries; Cerebrovascular Circulation; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Flavins; Homeostasis; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitrites; Pia Mater; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2B; Receptors, Purinergic P1; Thionucleotides; Triazines; Triazoles; Vasodilation | 2000 |
Antagonism of coronary artery relaxation by adenosine A2A-receptor antagonist ZM241385.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Antihypertensive Agents; Coronary Vessels; Dinoprost; Dose-Response Relationship, Drug; Drug Interactions; Endothelium, Vascular; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Phenethylamines; Purinergic P1 Receptor Antagonists; Pyrimidines; Receptors, Purinergic P1; Swine; Triazines; Triazoles; Vasodilator Agents | 2000 |
Adenosine mediates nitric-oxide-independent renal vasodilation by activation of A2A receptors.
Topics: Adenosine; Animals; Endothelium, Vascular; Female; In Vitro Techniques; Male; Nitric Oxide; Phenethylamines; Potassium; Potassium Channels; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rabbits; Receptors, Purinergic; Renal Artery; Triazines; Triazoles; Vasodilation; Vasodilator Agents | 1999 |
Tonic adenosine neuromodulation is preserved in motor nerve endings of aged rats.
Topics: Acetylcholine; Adenosine; Aging; Animals; Electric Stimulation; Male; Motor Neurons; Nerve Endings; Neurotransmitter Agents; Phrenic Nerve; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Triazines; Triazoles; Xanthines | 2000 |
A novel adenosine analog, AMP579, inhibits neutrophil activation, adherence and neutrophil-mediated injury to coronary vascular endothelium.
Topics: Animals; Cell Adhesion; Cell Degranulation; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Imidazoles; In Vitro Techniques; Male; Neutrophil Activation; Neutrophils; Pyridines; Quinazolines; Superoxides; Triazines; Triazoles; Vasodilation; Xanthines | 2000 |
Accelerated resequestration of cytosolic calcium and suppression of the pro-inflammatory activities of human neutrophils by CGS 21680 in vitro.
Topics: Adenosine; Calcium; Calcium Radioisotopes; Cyclic AMP; Cytosol; Dose-Response Relationship, Drug; Fura-2; Humans; Inflammation; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pancreatic Elastase; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P2 Receptor Antagonists; Superoxides; Thapsigargin; Triazines; Triazoles | 2000 |
Down-regulation of vascular endothelial growth factor expression after A(2A) adenosine receptor activation in PC12 pheochromocytoma cells.
Topics: Adenosine; Animals; Down-Regulation; Endothelial Growth Factors; Gene Expression Regulation; Lymphokines; PC12 Cells; Phenethylamines; Rats; Receptors, Purinergic P1; RNA, Messenger; Signal Transduction; Triazines; Triazoles; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
Adenosine A2A receptors regulate the extracellular accumulation of excitatory amino acids upon metabolic dysfunction in chick cultured retinal cells.
Topics: Adenosine; Analysis of Variance; Animals; Aspartic Acid; Bicuculline; Cells, Cultured; Chick Embryo; Chromatography, High Pressure Liquid; Excitatory Amino Acids; Extracellular Space; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycolysis; Humans; Ischemia; Organophosphorus Compounds; Purinergic P1 Receptor Antagonists; Pyrimidines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Retina; Triazines; Triazoles; Xanthines | 2000 |
Extracellular ATP reduces optically monitored electrical signals in hippocampal slices through metabolism to adenosine.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Hippocampus; Organ Culture Techniques; Rats; Rats, Wistar; Signal Transduction; Triazines; Triazoles; Uridine Diphosphate; Xanthines | 2000 |
SCH 58261 and ZM 241385 differentially prevent the motor effects of CGS 21680 in mice: evidence for a functional 'atypical' adenosine A(2A) receptor.
Topics: Adenosine; Animals; Dose-Response Relationship, Drug; Drug Interactions; Exploratory Behavior; Injections, Intraventricular; Male; Maze Learning; Mice; Mice, Knockout; Motor Activity; Neuroprotective Agents; Phenethylamines; Pyrimidines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Time Factors; Triazines; Triazoles | 2000 |
Adenosine A(2A) and A(2B) receptors in cultured human and porcine coronary artery endothelial cells.
Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Affinity Labels; Animals; Binding, Competitive; Cells, Cultured; Coronary Vessels; Cyclic AMP; Endothelium, Vascular; Gene Expression Regulation; Humans; Iodine Radioisotopes; Iodobenzenes; Kinetics; Phenethylamines; Purinergic P1 Receptor Antagonists; Radioligand Assay; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; Swine; Transcription, Genetic; Triazines; Triazoles | 2000 |
Site-directed mutagenesis studies of human A(2A) adenosine receptors: involvement of glu(13) and his(278) in ligand binding and sodium modulation.
Topics: Animals; Binding, Competitive; Drug Interactions; Glutamic Acid; Guanosine Triphosphate; Histidine; Humans; In Vitro Techniques; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Radioligand Assay; Receptor, Adenosine A2A; Receptors, Purinergic P1; Sodium; Triazines; Triazoles; Tritium | 2000 |
Allosteric modulation of A(2A) adenosine receptors by amiloride analogues and sodium ions.
Topics: Allosteric Regulation; Amiloride; Animals; Binding, Competitive; Cell Membrane; Corpus Striatum; Diuretics; Dose-Response Relationship, Drug; Drug Interactions; In Vitro Techniques; Purinergic P1 Receptor Antagonists; Radiopharmaceuticals; Rats; Receptor, Adenosine A2A; Receptors, Purinergic P1; Sodium; Sodium Chloride; Time Factors; Triazines; Triazoles; Tritium | 2000 |
Adenosine and selective A(2A) receptor agonists reduce ischemia/reperfusion injury of rat liver mainly by inhibiting leukocyte activation.
Topics: Adenosine; Alkynes; Animals; Calcium; Cells, Cultured; Chemokine CXCL1; Chemokines, CXC; Chemotactic Factors; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Ischemia; Leukocyte Elastase; Lipopolysaccharides; Liver; Male; Monocytes; Neutrophil Activation; Peroxidase; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A2A; Reperfusion Injury; Triazines; Triazoles; Tumor Necrosis Factor-alpha | 2000 |
Diadenosine polyphosphates facilitate the evoked release of acetylcholine from rat hippocampal nerve terminals.
Topics: Acetylcholine; Animals; Dinucleoside Phosphates; Hippocampus; Male; Presynaptic Terminals; Pyridoxal Phosphate; Rats; Rats, Wistar; Receptors, Purinergic P1; Suramin; Synaptosomes; Triazines; Triazoles; Tritium; Xanthines | 2000 |
Adenosine A(2A) receptors mediate cardiovascular responses to hypoxia in fetal sheep.
Topics: Adenosine; Animals; Blood Gas Analysis; Blood Pressure; Female; Fetal Hypoxia; Heart Rate; Hydrogen-Ion Concentration; Phenethylamines; Pregnancy; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A2A; Receptors, Purinergic P1; Sheep; Triazines; Triazoles; Xanthines | 2001 |
Potentiation of cytokine induction of group IIA phospholipase A(2) in rat mesangial cells by ATP and adenosine via the A2A adenosine receptor.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Deaminase; Adenosine Triphosphate; Animals; Blotting, Northern; Cells, Cultured; Enzyme Induction; Enzyme Inhibitors; Glomerular Mesangium; Group II Phospholipases A2; Interleukin-1; Phospholipases A; Purinergic P2 Receptor Antagonists; Rats; Receptor, Adenosine A2A; Receptors, Purinergic P1; RNA, Messenger; Signal Transduction; Suramin; Triazines; Triazoles; Uridine Triphosphate; Vasodilator Agents | 2001 |
Functional and molecular characterization of receptor subtypes mediating coronary microvascular dilation to adenosine.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Animals; Antihypertensive Agents; Blotting, Western; Colforsin; Coronary Vessels; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Glyburide; Heart; Hypoglycemic Agents; In Situ Hybridization; Male; Microcirculation; Myocardium; Peptides; Phenethylamines; Potassium Channel Blockers; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; Stress, Physiological; Swine; Thionucleotides; Tissue Distribution; Triazines; Triazoles | 2001 |
[(3)H]ZM241385--an antagonist radioligand for adenosine A(2A) receptors in rat brain.
Topics: Animals; Autoradiography; Binding, Competitive; Brain Chemistry; Female; Half-Life; In Vitro Techniques; Male; Membranes; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Rats, Wistar; Receptor, Adenosine A2A; Thermodynamics; Triazines; Triazoles | 2001 |
Absence of the adenosine A(2A) receptor or its chronic blockade decrease ethanol withdrawal-induced seizures in mice.
Topics: Administration, Oral; Alcohol Withdrawal Seizures; Animals; Beverages; Cacao; Disease Models, Animal; Drug Administration Schedule; Eating; Ethanol; Female; Flavoring Agents; Injections, Intraperitoneal; Male; Mice; Mice, Knockout; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A2A; Receptors, Purinergic P1; Triazines; Triazoles | 2001 |
Cyclic AMP-dependent inhibition of human neutrophil oxidative activity by substituted 2-propynylcyclohexyl adenosine A(2A) receptor agonists.
Topics: Adenosine; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Humans; Neutrophils; Receptor, Adenosine A2A; Receptors, Purinergic P1; Respiratory Burst; Triazines; Triazoles | 2001 |
Receptor subtypes mediating adenosine-induced dilation of cerebral arterioles.
Topics: Adenosine; Adenosine Triphosphate; Animals; Antihypertensive Agents; Arterioles; Cerebrovascular Circulation; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Phenethylamines; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Triazines; Triazoles; Vasodilation | 2001 |
Adenosine A(2A) receptor stimulation reduces inflammation and neointimal growth in a murine carotid ligation model.
Topics: Animals; Arteriosclerosis; Carotid Artery Injuries; Cell Adhesion Molecules; Female; Inflammation; Leukocyte Count; Macrophages; Mice; Mice, Inbred C57BL; Neutrophils; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A2A; Receptors, Purinergic P1; Triazines; Triazoles | 2001 |
Selective A(2A) adenosine receptor activation reduces skin pressure ulcer formation and inflammation.
Topics: Animals; Cell Line; Cyclohexanecarboxylic Acids; Dermatitis; Drug Combinations; Humans; Ischemia; Leukocytes; Male; Necrosis; Pressure Ulcer; Purines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; Reference Values; Regional Blood Flow; Reperfusion Injury; Skin; Triazines; Triazoles | 2001 |
Adenosine A(1) and A(2A) receptors modulate sleep state and breathing in fetal sheep.
Topics: Adenosine; Animals; Fetus; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Respiratory Physiological Phenomena; Sheep; Sleep Stages; Triazines; Triazoles; Xanthines | 2001 |
Novel short-acting A2A adenosine receptor agonists for coronary vasodilation: inverse relationship between affinity and duration of action of A2A agonists.
Topics: Adenosine; Animals; Antihypertensive Agents; Coronary Vessels; Corpus Striatum; Cyclic AMP; Dose-Response Relationship, Drug; Female; Humans; Male; PC12 Cells; Phenethylamines; Purinergic P1 Receptor Agonists; Purines; Pyrazoles; Rats; Receptor, Adenosine A2A; Receptors, Purinergic P1; Swine; Triazines; Triazoles; Vasodilation; Vasodilator Agents | 2001 |
Adenosine-mediated inhibition of striatal GABAergic synaptic transmission during in vitro ischaemia.
Topics: Adenosine; Adenosine Triphosphate; Animals; Brain Ischemia; Corpus Striatum; gamma-Aminobutyric Acid; Male; Membrane Potentials; Neural Inhibition; Organ Culture Techniques; Patch-Clamp Techniques; Potassium Channels; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Synaptic Transmission; Triazines; Triazoles; Xanthines | 2001 |
Suppression of presynaptic responses to adenosine by activation of NMDA receptors.
Topics: Action Potentials; Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Baclofen; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; GABA Agonists; Glycine; Hippocampus; In Vitro Techniques; Kainic Acid; Long-Term Potentiation; Male; N-Methylaspartate; Phenethylamines; Presynaptic Terminals; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, N-Methyl-D-Aspartate; Time Factors; Triazines; Triazoles | 2001 |
Effects of adenosine receptor agonists and antagonists in a genetic animal model of primary paroxysmal dystonia.
Topics: Adenosine; Animals; Caffeine; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Dystonia; Female; Male; Mesocricetus; Muscle Contraction; Mutation; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Theobromine; Theophylline; Triazines; Triazoles; Xanthines | 2001 |
Adenosine-mediated hypotension in in vivo guinea-pig: receptors involved and role of NO.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Blood Pressure; Diphenhydramine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Heart Rate; Hypotension; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles; Vasodilator Agents; Xanthines | 2001 |
AMP-activated protein kinase is highly expressed in neurons in the developing rat brain and promotes neuronal survival following glucose deprivation.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apoptosis; Brain; Cell Survival; Cells, Cultured; Glucose; Hypoglycemic Agents; Immunohistochemistry; Male; Multienzyme Complexes; Neurons; Neuroprotective Agents; Oligonucleotides, Antisense; Protein Serine-Threonine Kinases; Protein Subunits; Rats; Rats, Sprague-Dawley; Ribonucleotides; Triazines; Triazoles; Xanthines | 2001 |
Effect of adenosine receptor blockade on pial arteriolar dilation during sciatic nerve stimulation.
Topics: Adenine; Administration, Topical; Animals; Electric Stimulation; Enzyme Inhibitors; Evoked Potentials, Somatosensory; Injections, Intraperitoneal; Male; Pia Mater; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Theophylline; Triazines; Triazoles; Vasodilation; Vasodilator Agents; Xanthines | 2001 |
Role of adenosine and P2 receptors in the penile tumescence in anesthetized dogs.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Anesthesia; Animals; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Injections, Intravenous; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Penile Erection; Penis; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Theophylline; Thionucleotides; Triazines; Triazoles | 2001 |
Oxygen delivery and oxygen consumption in rat hindlimb during systemic hypoxia: role of adenosine.
Topics: Adenosine; Animals; Hemodynamics; Hindlimb; Hypoxia; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Oxygen Consumption; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; Triazines; Triazoles; Vital Capacity; Xanthines | 2001 |
Solubilisation and immunoprecipitation of rat striatal adenosine A(2A) receptors.
Topics: Adenosine; Animals; Cholic Acids; Corpus Striatum; Detergents; Phenethylamines; Precipitin Tests; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Radioligand Assay; Rats; Receptor, Adenosine A2A; Receptors, Purinergic P1; Solubility; Triazines; Triazoles | 2001 |
Adenosine inhibits excitatory transmission to substantia gelatinosa neurons of the adult rat spinal cord through the activation of presynaptic A(1) adenosine receptor.
Topics: Adenosine; Age Factors; Analgesics; Animals; Antihypertensive Agents; Excitatory Postsynaptic Potentials; In Vitro Techniques; Male; Neural Inhibition; Neurons; Patch-Clamp Techniques; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Substantia Gelatinosa; Triazines; Triazoles; Xanthines | 2001 |
Purification and characterization of the human adenosine A(2a) receptor functionally expressed in Escherichia coli.
Topics: Escherichia coli; Humans; Receptors, Purinergic P1; Recombinant Fusion Proteins; Solubility; Triazines; Triazoles | 2002 |
Hippocampal injury and neurobehavioral deficits following hyperglycemic cerebral ischemia: effect of theophylline and ZM 241385.
Topics: Adenosine; Animals; Blood Glucose; Cell Death; Cerebral Infarction; Escape Reaction; Hippocampus; Injections, Intraperitoneal; Male; Maze Learning; Neurons; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles | 2002 |
Effects of CGS 21680, a selective adenosine A2A receptor agonist, on allergic airways inflammation in the rat.
Topics: Adenosine; Allergens; Animals; Anti-Inflammatory Agents; Asthma; Blood Pressure; Budesonide; Dose-Response Relationship, Drug; Inflammation; Lung; Male; Ovalbumin; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Rats, Inbred BN; Receptor, Adenosine A2A; Triazines; Triazoles; Vascular Resistance | 2002 |
Adenosine A(2A) receptors mediate hypoxic inhibition of fetal breathing in sheep.
Topics: Animals; Carbon Dioxide; Electroencephalography; Electrooculography; Eye Movements; Female; Fetal Blood; Fetal Hypoxia; Fetal Movement; Fetus; Hydrogen-Ion Concentration; Oxygen; Pregnancy; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A2A; Receptors, Purinergic P1; Respiration; Sheep; Triazines; Triazoles; Xanthines | 2002 |
Adenosine A(2A) receptor facilitation of hippocampal synaptic transmission is dependent on tonic A(1) receptor inhibition.
Topics: Adenosine; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cyclic AMP; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Humans; In Vitro Techniques; Ligands; Male; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; Signal Transduction; Synaptic Transmission; Transfection; Triazines; Triazoles; Xanthines | 2002 |
Synergistic up-regulation of vascular endothelial growth factor expression in murine macrophages by adenosine A(2A) receptor agonists and endotoxin.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Blotting, Western; Cells, Cultured; Drosophila Proteins; Endothelial Growth Factors; Female; Interferon-gamma; Lipopolysaccharides; Lymphokines; Macrophages, Peritoneal; Male; Membrane Glycoproteins; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phenethylamines; Protein Kinase Inhibitors; Purinergic P1 Receptor Agonists; Receptor, Adenosine A2A; Receptors, Cell Surface; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Theobromine; Toll-Like Receptor 4; Toll-Like Receptors; Triazines; Triazoles; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Xanthines | 2002 |
Selective allosteric enhancement of agonist binding and function at human A3 adenosine receptors by a series of imidazoquinoline derivatives.
Topics: Adenosine; Allosteric Regulation; Animals; Binding, Competitive; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Imidazoles; Iodine Radioisotopes; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Quinolines; Radioligand Assay; Rats; Receptor, Adenosine A2A; Receptor, Adenosine A3; Receptors, Purinergic P1; Triazines; Triazoles; Tritium; Xanthines | 2002 |
Effects of adenosine receptor agonists on guinea-pig isolated working hearts and the role of endothelium and NO.
Topics: Adenosine; Animals; Cyclooxygenase Inhibitors; Endothelium, Vascular; Guinea Pigs; Heart; Hemodynamics; In Vitro Techniques; Indomethacin; Male; Nitric Oxide; Nitric Oxide Synthase; Phenethylamines; Prostaglandins; Purinergic P1 Receptor Agonists; Triazines; Triazoles | 2002 |
Localization of adenosine A2A-receptors in rat brain with [3H]ZM-241385.
Topics: Animals; Brain; Male; Protein Binding; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; Triazines; Triazoles; Tritium | 2002 |
Transducing system operated by adenosine A(2A) receptors to facilitate acetylcholine release in the rat hippocampus.
Topics: Acetylcholine; Adenylyl Cyclases; Animals; Blotting, Western; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Activation; Hippocampus; In Vitro Techniques; Male; Nerve Endings; Protein Kinase C; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; Signal Transduction; Synaptosomes; Triazines; Triazoles; Xanthines | 2002 |
Low ethanol sensitivity and increased ethanol consumption in mice lacking adenosine A2A receptors.
Topics: Administration, Oral; Alcohol Drinking; Animals; Behavior, Animal; Body Temperature; Choice Behavior; Dose-Response Relationship, Drug; Drug Resistance; Drug Tolerance; Ethanol; Female; Hypothermia; Injections, Intraperitoneal; Male; Mice; Mice, Knockout; Purinergic P1 Receptor Antagonists; Quinine; Receptor, Adenosine A2A; Receptors, Purinergic P1; Reflex; Sex Factors; Sucrose; Triazines; Triazoles | 2002 |
Changes of peripheral A2A adenosine receptors in chronic heart failure and cardiac transplantation.
Topics: Binding, Competitive; Female; Heart Failure; Heart Transplantation; Humans; Kinetics; Lymphocytes; Male; Myocardium; Neutrophils; Receptor, Adenosine A2A; Receptors, Purinergic P1; Triazines; Triazoles; Tritium | 2003 |
Adenosine receptors mediate glutamate-evoked arteriolar dilation in the rat cerebral cortex.
Topics: Animals; Arterioles; Blood Pressure; Cerebrovascular Circulation; Excitatory Amino Acid Agonists; Glutamic Acid; Male; N-Methylaspartate; Pia Mater; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Triazines; Triazoles; Vasodilation | 2003 |
Regional differences in the adenosine A(2) receptor-mediated modulation of contractions in rat vas deferens.
Topics: Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Epididymis; Immunohistochemistry; In Vitro Techniques; Male; Muscle Contraction; Norepinephrine; Phenethylamines; Prostate; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; Theobromine; Triazines; Triazoles; Vas Deferens; Xanthines | 2003 |
Rapid modification of the glycocalyx caused by ischemia-reperfusion is inhibited by adenosine A2A receptor activation.
Topics: Animals; Arterioles; Biotransformation; Capillaries; Cyclohexanecarboxylic Acids; Erythrocytes; Glycocalyx; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Receptor, Adenosine A2A; Reperfusion Injury; Triazines; Triazoles | 2003 |
Involvement of adenosine A1 and A2A receptors in the motor effects of caffeine after its acute and chronic administration.
Topics: Adenosine; Amphetamine; Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Male; Motor Activity; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; Theophylline; Time Factors; Triazines; Triazoles; Tritium; Xanthines | 2003 |
Neuroprotection by caffeine and adenosine A2A receptor blockade of beta-amyloid neurotoxicity.
Topics: Adenosine A2 Receptor Antagonists; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Caffeine; Cells, Cultured; Central Nervous System Diseases; Cerebellum; Neurons; Neuroprotective Agents; Peptide Fragments; Rats; Rats, Wistar; Receptor, Adenosine A2A; Theophylline; Triazines; Triazoles | 2003 |
Induction of neurite outgrowth in PC12 cells by the bacterial nucleoside N6-methyldeoxyadenosine is mediated through adenosine A2a receptors and via cAMP and MAPK signaling pathways.
Topics: Adenosine; Animals; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cyclic AMP; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Deoxyadenosines; DNA-Binding Proteins; Enzyme Inhibitors; ets-Domain Protein Elk-1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Neurites; PC12 Cells; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Rats; Receptor, Adenosine A2A; Receptors, Purinergic P1; Second Messenger Systems; Transcription Factors; Triazines; Triazoles | 2003 |
The human D2 dopamine receptor synergizes with the A2A adenosine receptor to stimulate adenylyl cyclase in PC12 cells.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenine; Adenosine; Adenosine Deaminase; Adenosine Diphosphate; Adenylyl Cyclases; Animals; Benzamides; Binding, Competitive; Cell Cycle; Cell Membrane; Cofilin 1; Colforsin; Cyclic AMP; Cytoskeletal Proteins; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Enzyme Activation; Gene Expression; Glutamic Acid; Humans; Membrane Potentials; Patch-Clamp Techniques; PC12 Cells; Pertussis Toxin; Phenethylamines; Phosphodiesterase Inhibitors; Phosphoproteins; Propionates; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrrolidines; Quinpirole; Radioligand Assay; Rats; Receptors, Dopamine D2; Receptors, Purinergic P1; Thionucleotides; Transfection; Triazines; Triazoles; Xenopus Proteins | 2003 |
Adenosine A 2B receptors modulate cAMP levels and induce CREB but not ERK1/2 and p38 phosphorylation in rat skeletal muscle cells.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cells, Cultured; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phenethylamines; Phosphorylation; Rats; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptors, Purinergic P1; RNA; Triazines; Triazoles | 2003 |
Enhanced adenosine A2A receptor facilitation of synaptic transmission in the hippocampus of aged rats.
Topics: Adenosine; Adrenergic beta-Agonists; Aging; Animals; Blotting, Western; Cyclic AMP; Electrophysiology; Excitatory Postsynaptic Potentials; Hippocampus; Isoproterenol; Male; Neurons; Phenethylamines; Presynaptic Terminals; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; Synaptic Transmission; Triazines; Triazoles; Xanthines | 2003 |
Effects of adenosine receptor antagonists on pial arteriolar dilation during carbon dioxide inhalation.
Topics: Adenosine; Administration, Inhalation; Animals; Caffeine; Carbon Dioxide; Cerebral Cortex; Cerebral Veins; Cerebrovascular Circulation; Drug Interactions; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Rats, Sprague-Dawley; Triazines; Triazoles; Vasodilation; Vasodilator Agents; Xanthines | 2003 |
Brief, repeated, oxygen-glucose deprivation episodes protect neurotransmission from a longer ischemic episode in the in vitro hippocampus: role of adenosine receptors.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Antagonists; Animals; Brain Ischemia; Electric Stimulation; Excitatory Postsynaptic Potentials; Glucose; Hippocampus; Hypoxia; In Vitro Techniques; Ischemic Preconditioning; Male; Oxygen; Purinergic P1 Receptor Antagonists; Pyridines; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Adenosine A3; Receptors, Purinergic P1; Synaptic Transmission; Time Factors; Triazines; Triazoles; Xanthines | 2003 |
The effect of caffeine on peripheral vascular resistance in isolated perfused guinea pig hind limbs.
Topics: Adenosine; Animals; Caffeine; Dose-Response Relationship, Drug; Female; Flavins; Guinea Pigs; Hindlimb; Hypoxia; Iliac Artery; Iloprost; Male; Nitrogen; Norepinephrine; Perfusion; Triazines; Triazoles; Vascular Resistance; Vasoconstriction; Vasodilation | 2003 |
LTP-induced depression of response to hypoxia in hippocampus: effects of adenosine receptor activation.
Topics: Adenosine; Animals; Electric Stimulation; Hippocampus; Hypoxia; In Vitro Techniques; Long-Term Potentiation; Male; Membrane Potentials; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Triazines; Triazoles | 2003 |
Modulation of A2A adenosine receptors and associated Galphas proteins by ZM 241385 treatment of porcine coronary artery.
Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Coronary Vessels; Cyclic AMP; Male; Muscle, Smooth, Vascular; Swine; Triazines; Triazoles; Up-Regulation; Vasodilation | 2003 |
Adenosine A2A receptors and depression.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Antidepressive Agents; Behavior, Animal; Caffeine; Depression; Disease Models, Animal; Dopamine Antagonists; Drug Interactions; Haloperidol; Mice; Mice, Knockout; Motor Activity; Neurotransmitter Agents; Parkinsonian Disorders; Purines; Pyrimidines; Receptor, Adenosine A2A; Triazines; Triazoles | 2003 |
Discovery of nonxanthine adenosine A2A receptor antagonists for the treatment of Parkinson's disease.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Humans; Ligands; Mefloquine; Mice; Motor Activity; Neuroprotective Agents; Parkinsonian Disorders; Phenethylamines; Purines; Pyrimidines; Radioligand Assay; Rats; Triazines; Triazoles | 2003 |
Protection from ischemic liver injury by activation of A2A adenosine receptors during reperfusion: inhibition of chemokine induction.
Topics: Adenosine A2 Receptor Agonists; Animals; Blood Cells; Chemokines; Cyclohexanecarboxylic Acids; Cytokines; Drug Administration Schedule; Edema; Gene Deletion; Ischemia; Leukocytes; Liver; Liver Circulation; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Purines; Radioligand Assay; Receptor, Adenosine A2A; Reperfusion Injury; RNA, Messenger; Triazines; Triazoles | 2004 |
Input-specific modulation of neurotransmitter release in the lateral horn of the spinal cord via adenosine receptors.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Cells, Cultured; Excitatory Postsynaptic Potentials; Immunohistochemistry; Interneurons; Male; Neural Inhibition; Neurons; Neurotransmitter Agents; Patch-Clamp Techniques; Phenethylamines; Presynaptic Terminals; Rats; Receptor, Adenosine A1; Receptor, Adenosine A2A; Spinal Cord; Triazines; Triazoles | 2004 |
Adenosine administration produces an antidepressant-like effect in mice: evidence for the involvement of A1 and A2A receptors.
Topics: Adenosine; Animals; Antidepressive Agents; Caffeine; Depressive Disorder; Disease Models, Animal; Female; Male; Mice; Motor Activity; Receptor, Adenosine A1; Receptor, Adenosine A2A; Stress, Psychological; Triazines; Triazoles; Xanthines | 2004 |
Involvement of adenosine A1 receptors in forced walking stress-induced analgesia in mice.
Topics: Adenosine A1 Receptor Antagonists; Analgesia; Animals; Behavior, Animal; Formaldehyde; Male; Mice; Mice, Inbred Strains; Pain; Receptor, Adenosine A1; Stress, Psychological; Theophylline; Triazines; Triazoles; Walking; Xanthines | 2003 |
Role of adenosine A2A receptor in the regulation of gastric somatostatin release.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Gastric Mucosa; Male; Phenethylamines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Somatostatin; Stomach; Tissue Distribution; Triazines; Triazoles; Xanthines | 2004 |
Effect of taurine deficiency on adenosine receptor-mediated relaxation of the rat aorta.
Topics: 2-Chloroadenosine; Acetylcholine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Aorta, Thoracic; beta-Alanine; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phenylephrine; Rats; Rats, Inbred WKY; Receptors, Purinergic P1; Taurine; Triazines; Triazoles; Vasoconstrictor Agents; Vasodilator Agents | 2003 |
Neutrophils both reduce and increase permeability in a cell culture model of the blood-brain barrier.
Topics: Adenosine; Adenosine Deaminase; Animals; Aprotinin; Blood-Brain Barrier; Capillary Permeability; Catalase; Cell Culture Techniques; Cell Movement; Cells, Cultured; Egtazic Acid; Electric Impedance; Endothelial Cells; Free Radicals; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Superoxide Dismutase; Triazines; Triazoles | 2004 |
Binding of tritiated and radioiodinated ZM241,385 to brain A2A adenosine receptors.
Topics: Animals; Brain; Iodine Radioisotopes; Isotope Labeling; Metabolic Clearance Rate; Organ Specificity; Protein Binding; Radionuclide Imaging; Radiopharmaceuticals; Rats; Receptor, Adenosine A2A; Tissue Distribution; Triazines; Triazoles; Tritium | 2004 |
Adenosine A 2A receptor antagonists prevent the increase in striatal glutamate levels induced by glutamate uptake inhibitors.
Topics: Adenosine A2 Receptor Antagonists; Animals; Corpus Striatum; Dicarboxylic Acids; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Glutamic Acid; Kainic Acid; Male; Microdialysis; Neuroprotective Agents; Neurotransmitter Uptake Inhibitors; Pyrimidines; Pyrrolidines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Triazines; Triazoles | 2004 |
Activation of adenosine A2A receptor facilitates brain-derived neurotrophic factor modulation of synaptic transmission in hippocampal slices.
Topics: Adenosine; Adenosine Kinase; Animals; Brain-Derived Neurotrophic Factor; Bucladesine; Carbazoles; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Indole Alkaloids; Long-Term Potentiation; Male; Patch-Clamp Techniques; Phenethylamines; Potassium; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptor, trkB; Synaptic Transmission; Triazines; Triazoles | 2004 |
AMPA receptor-mediated presynaptic inhibition at cerebellar GABAergic synapses: a characterization of molecular mechanisms.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Benzoxazines; Calcium; Calcium Channel Blockers; Cerebellum; Chelating Agents; Colforsin; Cyclopropanes; Drug Interactions; Egtazic Acid; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Piperidines; Presynaptic Terminals; Pyrazoles; Rats; Rats, Wistar; Receptors, AMPA; Ryanodine; Synapses; Triazines; Triazoles | 2004 |
Endogenous adenosine modulates epileptiform activity in rat hippocampus in a receptor subtype-dependent manner.
Topics: Adenosine; Animals; Animals, Newborn; Dihydropyridines; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Indoles; Maleimides; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Seizures; Theophylline; Time Factors; Triazines; Triazoles | 2004 |
The role of intraspinal adenosine A1 receptors in sympathetic regulation.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Dihydropyridines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Spinal Cord; Splanchnic Nerves; Sympathetic Nervous System; Synaptic Transmission; Theobromine; Theophylline; Triazines; Triazoles | 2004 |
Adenosine A2A receptor occupancy stimulates expression of proteins involved in reverse cholesterol transport and inhibits foam cell formation in macrophages.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Arteriosclerosis; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Carrier Proteins; Cell Differentiation; Cholestanetriol 26-Monooxygenase; Cholesterol; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Foam Cells; Gene Expression Regulation, Enzymologic; Humans; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Phenethylamines; Receptor, Adenosine A2A; RNA, Messenger; Steroid Hydroxylases; Triazines; Triazoles; Up-Regulation | 2004 |
Adenosine A2A receptor blockade differentially influences excitotoxic mechanisms at pre- and postsynaptic sites in the rat striatum.
Topics: 4-Aminopyridine; Adenosine; Adenosine A2 Receptor Antagonists; Animals; Calcium; Corpus Striatum; Dose-Response Relationship, Drug; Glutamic Acid; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Models, Biological; N-Methylaspartate; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Phenethylamines; Pyrimidines; Quinolinic Acid; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes; Synaptic Transmission; Triazines; Triazoles | 2004 |
Adenosine's role in hypercapnia-evoked cerebral vasodilation in the rat.
Topics: Adenosine; Animals; Carbon Dioxide; Cerebrovascular Circulation; Hypercapnia; Male; Microscopy, Video; Nitric Oxide; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Triazines; Triazoles; Vasodilation | 2004 |
Striatal adenosine A(2A) receptor blockade increases extracellular dopamine release following l-DOPA administration in intact and dopamine-denervated rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Area Under Curve; Brain Chemistry; Chromatography, High Pressure Liquid; Corpus Striatum; Denervation; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Extracellular Space; Homovanillic Acid; Hydroxyindoleacetic Acid; Levodopa; Male; Malonates; Methyltyrosines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Reserpine; Serotonin; Substantia Nigra; Time Factors; Triazines; Triazoles; Xanthines | 2004 |
Permissive role of adenosine A2A receptors on metabotropic glutamate receptor 5 (mGluR5)-mediated effects in the striatum.
Topics: Adenosine; Animals; Carbazoles; Cells, Cultured; Corpus Striatum; Dose-Response Relationship, Drug; Drug Interactions; Electrophysiology; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glycine; In Vitro Techniques; Indoles; Male; Membrane Potentials; N-Methylaspartate; Phenethylamines; Phenylacetates; Pregnancy; Purinergic P1 Receptor Agonists; Pyridines; Pyrroles; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Adenosine A2; Receptors, Metabotropic Glutamate; Triazines; Triazoles | 2004 |
Adenosine A1 receptors modulate the anxiolytic-like effect of ethanol in the elevated plus-maze in mice.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Caffeine; Dose-Response Relationship, Drug; Drug Synergism; Ethanol; Male; Maze Learning; Mice; Receptor, Adenosine A1; Triazines; Triazoles; Xanthines | 2004 |
Characterization of [3H]ZM 241385 binding in wild-type and adenosine A2A receptor knockout mice.
Topics: Animals; Binding Sites; Brain; Dose-Response Relationship, Drug; Male; Mice; Mice, Knockout; Protein Binding; Receptor, Adenosine A2A; Triazines; Triazoles; Tritium | 2004 |
Crucial role for ecto-5'-nucleotidase (CD73) in vascular leakage during hypoxia.
Topics: 5'-Nucleotidase; Adenosine; Animals; Capillary Permeability; Hypoxia; Lung; Mice; Triazines; Triazoles | 2004 |
Adenosine A2A-receptor blockade abolishes the roll-off respiratory response to hypoxia in awake lambs.
Topics: Adenosine A2 Receptor Antagonists; Animals; Animals, Newborn; Blood Pressure; Body Temperature; Carbon Dioxide; Heart Rate; Hydrogen-Ion Concentration; Hypoxia; Oxygen; Receptor, Adenosine A2A; Respiration; Sheep; Tidal Volume; Time Factors; Triazines; Triazoles; Xanthines | 2005 |
A2A adenosine receptor induction inhibits IFN-gamma production in murine CD4+ T cells.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; CD4-Positive T-Lymphocytes; Cell Line; Cyclic AMP; Cyclohexanecarboxylic Acids; Gene Dosage; Humans; Interferon-gamma; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Purines; Receptor, Adenosine A2A; Receptors, Antigen, T-Cell; RNA, Messenger; Rolipram; Triazines; Triazoles | 2005 |
A2B adenosine receptor mediates human chorionic vasoconstriction and signals through arachidonic acid cascade.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Arachidonic Acid; Chorion; Endothelium, Vascular; Female; Humans; In Vitro Techniques; Placenta; Pregnancy; Receptor, Adenosine A2B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Triazines; Triazoles; Vasoconstriction; Vasodilator Agents; Xanthines | 2005 |
In vivo adenosine receptor preconditioning reduces myocardial infarct size via subcellular ERK signaling.
Topics: Animals; Butadienes; Enzyme Inhibitors; Imidazoles; Ischemic Preconditioning, Myocardial; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardial Infarction; Nitriles; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Reperfusion Injury; Subcellular Fractions; Triazines; Triazoles; Xanthines | 2005 |
Kinetic and functional properties of [3H]ZM241385, a high affinity antagonist for adenosine A2A receptors.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Algorithms; Animals; Binding, Competitive; Cell Membrane; CHO Cells; Cricetinae; Cyclic AMP; GTP-Binding Proteins; Kinetics; Ligands; Neostriatum; Phenethylamines; Radioligand Assay; Triazines; Triazoles | 2005 |
Adenosine contributes to mu-opioid synaptic inhibition in rat substantia gelatinosa in vitro.
Topics: Adenosine; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Postsynaptic Potentials; Neural Inhibition; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Rats; Receptors, Opioid, mu; Receptors, Purinergic P1; Substantia Gelatinosa; Synapses; Triazines; Triazoles; Xanthines | 2005 |
Upregulation of A2A adenosine receptor expression by TNF-alpha in PBMC of patients with CHF: a regulatory mechanism of inflammation.
Topics: Adenosine; Blotting, Western; Female; Heart Failure; Humans; Lipopolysaccharides; Male; Middle Aged; Neutrophils; Phenethylamines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; Triazines; Triazoles; Tumor Necrosis Factor-alpha; Up-Regulation | 2005 |
Modulation of short-term social memory in rats by adenosine A1 and A(2A) receptors.
Topics: Adenosine; Animals; Behavior, Animal; Brain; Caffeine; Dose-Response Relationship, Drug; Drug Administration Schedule; Injections, Intraperitoneal; Male; Memory, Short-Term; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptor, Adenosine A2A; Social Behavior; Triazines; Triazoles; Xanthines | 2005 |
Adenosine agonist regulation of outward active transport of fluorescein across retinal pigment epithelium in rabbits.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Biological Transport, Active; Dihydropyridines; Fluorescein; Fluoresceins; Fluorophotometry; Injections, Intravenous; Male; Pigment Epithelium of Eye; Purinergic P1 Receptor Antagonists; Rabbits; Retinal Detachment; Triazines; Triazoles; Xanthines | 2005 |
Blockade of adenosine A2A receptors reverses short-term social memory impairments in spontaneously hypertensive rats.
Topics: Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Caffeine; Discrimination Learning; Habituation, Psychophysiologic; Male; Memory Disorders; Memory, Short-Term; Rats; Rats, Inbred SHR; Rats, Wistar; Receptor, Adenosine A2A; Recognition, Psychology; Smell; Social Behavior; Social Environment; Species Specificity; Triazines; Triazoles; Xanthines | 2005 |
Activation of adenosine receptors in the posterior cingulate cortex impairs memory retrieval in the rat.
Topics: Adenosine; Animals; Avoidance Learning; Cerebral Cortex; Exploratory Behavior; Gyrus Cinguli; Male; Memory; Microinjections; Phenethylamines; Purinergic Agonists; Purinergic Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptor, Adenosine A2A; Triazines; Triazoles; Xanthines | 2005 |
Effects of adenosine and adenosine A2A receptor agonist on motor nerve conduction velocity and nerve blood flow in experimental diabetic neuropathy.
Topics: Adenosine; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Interactions; Neural Conduction; Phenethylamines; Purinergic P2 Receptor Agonists; Rats; Regional Blood Flow; Sciatic Nerve; Staining and Labeling; Streptozocin; Theophylline; Time Factors; Triazines; Triazoles | 2005 |
Effect of sleep deprivation on righting reflex in the rat is partially reversed by administration of adenosine A1 and A2 receptor antagonists.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Drug Combinations; Male; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptors, Adenosine A2; Reflex; Sleep Deprivation; Theophylline; Triazines; Triazoles | 2005 |
Postconditioning reduces infarct size via adenosine receptor activation by endogenous adenosine.
Topics: Adenosine; Animals; Male; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Perfusion; Purinergic P1 Receptor Antagonists; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles; Xanthines | 2005 |
Adenosine receptors co-operate with NMDA preconditioning to protect cerebellar granule cells against glutamate neurotoxicity.
Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Animals; Animals, Newborn; Cell Death; Cells, Cultured; Cerebellum; Cyclic AMP; Drug Antagonism; Excitatory Amino Acid Agonists; Glutamic Acid; Hydrolysis; N-Methylaspartate; Neurons; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles | 2005 |
Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adenylyl Imidodiphosphate; Animals; Astrocytoma; Calcium; Cell Line; Cell Line, Tumor; Glutamic Acid; Hippocampus; Kidney; Male; Potassium; Pyramidal Cells; Pyridoxal Phosphate; Rats; Rats, Wistar; Receptors, Presynaptic; Receptors, Purinergic P2; Receptors, Purinergic P2X; Receptors, Purinergic P2X2; Receptors, Purinergic P2X3; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y2; Recombinant Fusion Proteins; RNA, Messenger; Subcellular Fractions; Suramin; Synaptosomes; Transfection; Triazines; Triazoles; Xanthines | 2005 |
Lipopolysaccharide rapidly modifies adenosine receptor transcripts in murine and human macrophages: role of NF-kappaB in A(2A) adenosine receptor induction.
Topics: Animals; Cells, Cultured; Cyclohexanecarboxylic Acids; Gene Expression Regulation; Humans; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Nitriles; Protein Binding; Purines; Receptor, Adenosine A2A; RNA, Messenger; Sulfones; Transcription, Genetic; Triazines; Triazoles; Tumor Necrosis Factor-alpha | 2005 |
Adenosine A2A receptor stimulation potentiates nitric oxide release by activated microglia.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Animals, Newborn; Blotting, Western; Cell Proliferation; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Immunohistochemistry; Indoles; Lipopolysaccharides; Maleimides; Mice; Mice, Inbred C57BL; Microglia; Nitric Oxide; Nitrites; Phenethylamines; Protein Binding; Radioligand Assay; Receptor, Adenosine A2A; Time Factors; Triazines; Triazoles; Tritium; Tumor Necrosis Factor-alpha | 2005 |
Tachycardia caused by A2A adenosine receptor agonists is mediated by direct sympathoexcitation in awake rats.
Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Male; Norepinephrine; Purines; Pyrazoles; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Tachycardia; Time Factors; Triazines; Triazoles | 2006 |
The cellular mechanisms by which adenosine evokes release of nitric oxide from rat aortic endothelium.
Topics: Adenosine; Animals; Aorta, Thoracic; Apamin; Arachidonic Acids; Calcium; Endothelium, Vascular; In Vitro Techniques; Large-Conductance Calcium-Activated Potassium Channels; Male; Nitric Oxide; Peptides; Phospholipases A; Phospholipases A2; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptors, Adenosine A2; Second Messenger Systems; Small-Conductance Calcium-Activated Potassium Channels; Triazines; Triazoles; Vasodilator Agents; Xanthines | 2006 |
Adenosine concentration in the porcine coronary artery wall and A2A receptor involvement in hypoxia-induced vasodilatation.
Topics: Acetamides; Adenosine; Adenosine A2 Receptor Antagonists; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Coronary Vessels; Dose-Response Relationship, Drug; Glucose; Hypoxia; In Vitro Techniques; Lactates; Purines; Pyruvic Acid; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Swine; Triazines; Triazoles; Vasodilation | 2006 |
Adenosine A1 and A2A receptors of hippocampal CA1 region have opposite effects on piriform cortex kindled seizures in rats.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Cerebral Cortex; Electric Stimulation; Hippocampus; Kindling, Neurologic; Male; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptors, Purinergic P2; Seizures; Triazines; Triazoles; Xanthines | 2006 |
Adenosine A2A receptors promote adenosine-stimulated wound healing in bronchial epithelial cells.
Topics: Adenosine; Bronchi; Cell Division; Cell Line; Cell Movement; Humans; Kinetics; Receptor, Adenosine A2A; Respiratory Mucosa; Transcription, Genetic; Triazines; Triazoles; Wound Healing; Wounds and Injuries | 2006 |
A2a receptors mediate inhibitory effects of adenosine on colonic motility in the presence of experimental colitis.
Topics: Adenosine; Animals; Colitis; Disease Models, Animal; Gastrointestinal Motility; Intestinal Mucosa; Male; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Reverse Transcriptase Polymerase Chain Reaction; Sensitivity and Specificity; Tissue Culture Techniques; Triazines; Triazoles | 2006 |
Adenosine as an active component of Antrodia cinnamomea that prevents rat PC12 cells from serum deprivation-induced apoptosis through the activation of adenosine A(2A) receptors.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Aminohydrolases; Animals; Apoptosis; Culture Media, Serum-Free; Inosine; PC12 Cells; Polyporales; Rats; Triazines; Triazoles | 2006 |
Effects of the A 2A adenosine receptor antagonist KW6002 in the nucleus accumbens in vitro and in vivo.
Topics: Animals; Binding, Competitive; Conditioning, Operant; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Microdialysis; Motor Activity; Nucleus Accumbens; Purines; Rats; Receptor, Adenosine A2A; Triazines; Triazoles; Xanthines | 2006 |
Dialysis delivery of an adenosine A2A agonist into the pontine reticular formation of C57BL/6J mouse increases pontine acetylcholine release and sleep.
Topics: Acetylcholine; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Dose-Response Relationship, Drug; Extracellular Fluid; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred C57BL; Microdialysis; Neural Inhibition; Neural Pathways; Phenethylamines; Pons; Receptor, Adenosine A2A; Reticular Formation; Sleep; Sleep, REM; Synaptic Transmission; Triazines; Triazoles; Up-Regulation; Wakefulness | 2006 |
Neurogenic secretion mediated by the purinergic P2Y1 receptor in guinea-pig small intestine.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Bumetanide; Chlorides; Dose-Response Relationship, Drug; Electric Stimulation; Electrolytes; Gene Expression; Guinea Pigs; In Vitro Techniques; Intestine, Small; Male; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Vasoactive Intestinal Polypeptide, Type I; Signal Transduction; Sodium Potassium Chloride Symporter Inhibitors; Tetrodotoxin; Theophylline; Triazines; Triazoles; Vasoactive Intestinal Peptide | 2006 |
Both endothelium and afferent nerve endings play a role in acetylcholine-induced renal vasodilation.
Topics: Acetylcholine; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Female; Glycyrrhetinic Acid; Indomethacin; Male; Nerve Endings; Neurons, Afferent; Nitric Oxide; Nitric Oxide Synthase Type III; Nitroarginine; Octoxynol; Rats; Rats, Wistar; Renal Circulation; Second Messenger Systems; Triazines; Triazoles; Vasodilator Agents | 2006 |
Adenosine A2A receptor inactivation increases survival in polymicrobial sepsis.
Topics: Adenosine A2 Receptor Antagonists; Animals; Apoptosis; Bacteremia; Biomarkers; Cytokines; Gene Expression Profiling; Male; Mice; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Receptor, Adenosine A2A; Spleen; Survival Rate; Triazines; Triazoles | 2006 |
Early and transient alteration of adenosine A2A receptor signaling in a mouse model of Huntington disease.
Topics: Adenylyl Cyclases; Animals; Basal Ganglia; Cyclic AMP; Disease Models, Animal; Huntington Disease; Mice; Mice, Transgenic; Receptors, Adenosine A2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Triazines; Triazoles | 2006 |
Adenosine A2A receptor stimulation decreases GAT-1-mediated GABA uptake in the globus pallidus of the rat.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adenosine A2 Receptor Agonists; Animals; Colforsin; Cyclic AMP-Dependent Protein Kinases; Data Interpretation, Statistical; Enzyme Inhibitors; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Globus Pallidus; In Vitro Techniques; Isoquinolines; Male; Okadaic Acid; Phenethylamines; Rats; Rats, Wistar; Sulfonamides; Synapses; Triazines; Triazoles | 2006 |
Role of adenosine A1 receptors in the modulation of dopamine D1 and adenosine A2A receptor signaling in the neostriatum.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Benzazepines; Dopamine and cAMP-Regulated Phosphoprotein 32; Dopamine Antagonists; Drug Interactions; Gene Expression; In Vitro Techniques; Mice; Mice, Inbred C57BL; Neostriatum; Phenethylamines; Raclopride; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptors, Dopamine D1; Signal Transduction; Threonine; Triazines; Triazoles; Xanthines | 2006 |
Adenosine receptors located in the NTS contribute to renal sympathoinhibition during hypotensive phase of severe hemorrhage in anesthetized rats.
Topics: Anesthesia; Animals; Blood Pressure; Heart Rate; Hemorrhage; Kidney; Male; Microinjections; Neural Inhibition; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Solitary Nucleus; Sympathetic Nervous System; Theophylline; Triazines; Triazoles | 2006 |
Characterization of [125I]ZM 241385 binding to adenosine A2A receptors in the pineal of sheep brain.
Topics: Adenosine; Algorithms; Animals; Autoradiography; Binding Sites; Binding, Competitive; Brain; Brain Chemistry; Data Interpretation, Statistical; Diencephalon; Female; In Vitro Techniques; Iodine Radioisotopes; Membranes; Pineal Gland; Pregnancy; Receptor, Adenosine A2A; Receptors, G-Protein-Coupled; Sheep; Thalamic Nuclei; Triazines; Triazoles | 2006 |
Mouse spinal cord compression injury is reduced by either activation of the adenosine A2A receptor on bone marrow-derived cells or deletion of the A2A receptor on non-bone marrow-derived cells.
Topics: Adenosine A2 Receptor Agonists; Analysis of Variance; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Female; Mice; Mice, Knockout; Motor Activity; Myelin Sheath; Piperidines; Radioligand Assay; Receptor, Adenosine A2A; Spinal Cord Compression; Time Factors; Triazines; Triazoles | 2006 |
Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Blotting, Western; Caffeine; Carbon Tetrachloride; Cell Line; Chromatography, High Pressure Liquid; Ethanol; Hepatocytes; Humans; Liver Cirrhosis; Matrix Metalloproteinases, Membrane-Associated; Methotrexate; Mice; Mice, Inbred C57BL; Rats; Receptor, Adenosine A2A; Reverse Transcriptase Polymerase Chain Reaction; Thioacetamide; Triazines; Triazoles | 2006 |
Caffeine inhibition of rat carotid body chemoreceptors is mediated by A2A and A2B adenosine receptors.
Topics: Adenosine; Animals; Caffeine; Carotid Body; Catecholamines; Central Nervous System Stimulants; Chemoreceptor Cells; Dose-Response Relationship, Drug; Female; Hypoxia; Immunohistochemistry; Male; Potassium; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptors, Presynaptic; Respiratory Mechanics; Triazines; Triazoles; Xanthines | 2006 |
Contribution of adenosine receptors in the control of arteriolar tone and adenosine-angiotensin II interaction.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Angiotensin II; Animals; Arterioles; Feedback; Female; Kidney Glomerulus; Kidney Tubules; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenethylamines; Purines; Receptor, Adenosine A1; Receptors, Adenosine A2; Theophylline; Triazines; Triazoles; Vasoconstriction; Vasodilation | 2006 |
Adenosine A2A receptor modulation of juvenile female rat skeletal muscle microvessel permeability.
Topics: Adenine; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Aging; Animals; Arterioles; Cell Membrane Permeability; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gene Expression Regulation; Muscle, Skeletal; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Adenosine A2B; RNA, Messenger; Serum Albumin; Triazines; Triazoles; Vasodilator Agents; Venules | 2006 |
Adenosine A2A receptors in diffuse dermal fibrosis: pathogenic role in human dermal fibroblasts and in a murine model of scleroderma.
Topics: Animals; Cells, Cultured; Collagen; Dermis; Disease Models, Animal; Enzyme Inhibitors; Fibroblasts; Fibrosis; Gene Expression; Humans; Hydroxyproline; Male; MAP Kinase Kinase 1; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, Adenosine A2A; RNA, Messenger; Scleroderma, Diffuse; Triazines; Triazoles | 2006 |
Functional and cytoarchitectural spinal cord protection by ATL-146e after ischemia/reperfusion is mediated by adenosine receptor agonism.
Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Cell Survival; Cyclohexanecarboxylic Acids; Disease Models, Animal; Microtubule-Associated Proteins; Neurons; Neuroprotective Agents; Paraplegia; Purines; Rabbits; Receptor, Adenosine A2A; Reperfusion Injury; Spinal Cord; Spinal Cord Ischemia; Time Factors; Triazines; Triazoles | 2006 |
Deficits of glutamate transmission in the striatum of experimental hemiballism.
Topics: Anesthetics, Local; Animals; Corpus Striatum; Disease Models, Animal; Dopamine Antagonists; Dyskinesias; Electric Stimulation; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sulpiride; Synaptic Transmission; Tetrodotoxin; Triazines; Triazoles | 2006 |
The A2a/A2b receptor antagonist ZM-241385 blocks the cardioprotective effect of adenosine agonist pretreatment in in vivo rat myocardium.
Topics: Adenosine A2 Receptor Antagonists; Animals; Cardiotonic Agents; Drug Combinations; Male; Myocardial Ischemia; Premedication; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Treatment Outcome; Triazines; Triazoles | 2007 |
Cl-IB-MECA [2-chloro-N6-(3-iodobenzyl)adenosine-5'-N-methylcarboxamide] reduces ischemia/reperfusion injury in mice by activating the A3 adenosine receptor.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Blood Pressure; Cardiotonic Agents; Cell Degranulation; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Histamine; In Vitro Techniques; Male; Mice; Mice, Knockout; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; p-Methoxy-N-methylphenethylamine; Pyridines; Radioligand Assay; Receptor, Adenosine A3; Triazines; Triazoles | 2006 |
Expression of adenosine receptors in cardiac fibroblasts as a function of insulin and glucose level.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclases; Animals; Blotting, Western; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Fibroblasts; Gene Expression; Glucose; Heart Ventricles; Insulin; Male; Phenethylamines; Protein Isoforms; Rats; Rats, Wistar; Receptors, Purinergic P1; RNA, Messenger; Triazines; Triazoles | 2006 |
Stimulation of adenosine A1 and A2A receptors by AMP in the submucosal plexus of guinea pig small intestine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Action Potentials; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adenosine Diphosphate; Adenosine Monophosphate; Animals; Boron Compounds; Enzyme Inhibitors; Estrenes; Excitatory Postsynaptic Potentials; Guinea Pigs; Ileum; Indoles; Male; Maleimides; Norepinephrine; Phenethylamines; Pyrrolidinones; Quinazolines; Receptor, Adenosine A1; Receptor, Adenosine A2A; Signal Transduction; Submucous Plexus; Synaptic Transmission; Tetrodotoxin; Theophylline; Triazines; Triazoles | 2007 |
Tonic adenosine A1 and A2A receptor activation is required for the excitatory action of VIP on synaptic transmission in the CA1 area of the hippocampus.
Topics: Adenosine; Adenosine Deaminase; Analysis of Variance; Animals; Drug Interactions; Electric Stimulation; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Neuroprotective Agents; Patch-Clamp Techniques; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptor, Adenosine A2A; Synaptic Transmission; Triazines; Triazoles; Vasoactive Intestinal Peptide; Xanthines | 2007 |
Synergistic up-regulation of vascular endothelial growth factor (VEGF) expression in macrophages by adenosine A2A receptor agonists and endotoxin involves transcriptional regulation via the hypoxia response element in the VEGF promoter.
Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Cell Hypoxia; DNA; Exons; Female; Hypoxia-Inducible Factor 1, alpha Subunit; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Response Elements; RNA, Messenger; Sequence Deletion; Toll-Like Receptor 4; Transcription, Genetic; Triazines; Triazoles; Tumor Necrosis Factor-alpha; Up-Regulation; Vascular Endothelial Growth Factor A | 2007 |
ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor.
Topics: Adenosine A2 Receptor Agonists; Humans; Mutation; Purines; Saccharomyces cerevisiae; Triazines; Triazoles; Xanthines | 2007 |
Disruption of adenosinergic modulation of ventilation at rest and during hypercapnia by neonatal caffeine in young rats: role of adenosine A(1) and A(2A) receptors.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Central Nervous System Stimulants; Hypercapnia; Injections, Intraperitoneal; Male; Plethysmography; Pulmonary Ventilation; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Rest; Time Factors; Triazines; Triazoles; Xanthines | 2007 |
Cell death in rat cerebellar granule neurons induced by hydrogen peroxide in vitro: mechanisms and protection by adenosine receptor ligands.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Animals, Newborn; Apoptosis; Brain Diseases; Catalase; Cell Death; Cell Survival; Cells, Cultured; Cerebellar Cortex; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hydrogen Peroxide; Necrosis; Neurons; Oxidative Stress; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptors, Adenosine A2; Receptors, Purinergic P1; Time Factors; Triazines; Triazoles | 2007 |
Attenuation of reperfusion lung injury and apoptosis by A2A adenosine receptor activation is associated with modulation of Bcl-2 and Bax expression and activation of extracellular signal-regulated kinases.
Topics: Adenosine A2 Receptor Agonists; Animals; Apoptosis; bcl-2-Associated X Protein; Cats; Extracellular Signal-Regulated MAP Kinases; Lung; Lung Injury; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Piperidines; Proto-Oncogene Proteins c-bcl-2; Pulmonary Alveoli; Receptor, Adenosine A2A; Reperfusion Injury; Triazines; Triazoles; Wounds and Injuries | 2007 |
Interleukin-1beta but not tumor necrosis factor-alpha potentiates neuronal damage by quinolinic acid: protection by an adenosine A2A receptor antagonist.
Topics: Adenosine A2 Receptor Antagonists; Animals; Brain Injuries; Brain Ischemia; Cytoprotection; Drug Synergism; Hippocampus; Interleukin-1beta; Male; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Pyramidal Cells; Quinolinic Acid; Rats; Rats, Wistar; Receptor, Adenosine A2A; Triazines; Triazoles; Tumor Necrosis Factor-alpha | 2007 |
Increase in A2A receptors in the nucleus accumbens after extended cocaine self-administration and its disappearance after cocaine withdrawal.
Topics: Animals; Behavior, Animal; Binding, Competitive; Cocaine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Male; Nucleus Accumbens; Raclopride; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Reinforcement Schedule; Self Administration; Substance Withdrawal Syndrome; Time Factors; Triazines; Triazoles; Tritium | 2007 |
The role of adenosine A2a receptors in experimental acute pancreatitis.
Topics: Acute Disease; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Amylases; Animals; Disease Models, Animal; Immunohistochemistry; Lipase; Male; Pancreas; Pancreatitis; Phenethylamines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Taurocholic Acid; Triazines; Triazoles | 2006 |
Activation of adenosine 2A receptors attenuates allograft rejection and alloantigen recognition.
Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Antibodies, Monoclonal; Antigen-Presenting Cells; Antigens, CD; Antigens, Differentiation; CD3 Complex; CD40 Ligand; CTLA-4 Antigen; Cytokines; Graft Rejection; Interferon-gamma; Interleukin-2 Receptor alpha Subunit; Isoantigens; Lymphocyte Activation; Mice; Mice, Knockout; Piperidines; Programmed Cell Death 1 Receptor; Receptor, Adenosine A2A; Reperfusion Injury; Skin Transplantation; T-Lymphocytes; Triazines; Triazoles; ZAP-70 Protein-Tyrosine Kinase | 2007 |
Endogenous expression of adenosine A1, A2 and A3 receptors in rat C6 glioma cells.
Topics: Adenylyl Cyclases; Animals; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Membrane; Fluorescent Antibody Technique; Glioma; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Molecular Sequence Data; Nerve Tissue Proteins; Protein Binding; Rats; Receptor, Adenosine A1; Receptor, Adenosine A3; Receptors, Adenosine A2; Reverse Transcriptase Polymerase Chain Reaction; Triazines; Triazoles; Xanthines | 2007 |
Adenosine closes the K+ channel KCa3.1 in human lung mast cells and inhibits their migration via the adenosine A2A receptor.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Benzimidazoles; Calcium Channel Agonists; Cations; Cell Movement; Culture Media, Conditioned; Electric Stimulation; Electrophysiology; Histamine; Humans; Immunoglobulin E; Intermediate-Conductance Calcium-Activated Potassium Channels; Lung; Mast Cells; Phenethylamines; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Triazines; Triazoles | 2007 |
Effects of stimulation of adenosine A2A receptors on lipopolysaccharide-induced production of reactive oxygen species by equine neutrophils.
Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Cyclic AMP; Dose-Response Relationship, Drug; Horses; Lipopolysaccharides; Neutrophils; Reactive Oxygen Species; Receptor, Adenosine A2A; Rolipram; Triazines; Triazoles | 2007 |
The role of adenosine A1 and A2A receptors of entorhinal cortex on piriform cortex kindled seizures in rats.
Topics: Adenosine; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Entorhinal Cortex; Kindling, Neurologic; Male; Microinjections; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Seizures; Triazines; Triazoles; Xanthines | 2007 |
Blockade of adenosine A(2A) receptors prevents staurosporine-induced apoptosis of rat hippocampal neurons.
Topics: Adenosine A2 Receptor Antagonists; Animals; Apoptosis; Blotting, Western; Cells, Cultured; Enzyme Inhibitors; Hippocampus; Immunohistochemistry; Male; Mitochondria; Neurons; Phosphoprotein Phosphatases; Rats; Rats, Wistar; Staurosporine; Synaptophysin; Triazines; Triazoles | 2007 |
Targeted deletion of A2A adenosine receptors attenuates the protective effects of myocardial postconditioning.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Disease Models, Animal; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardial Reperfusion Injury; Myocardium; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptor, Adenosine A2A; Research Design; Signal Transduction; Time Factors; Triazines; Triazoles; Troponin I; Ventricular Function, Left; Ventricular Pressure | 2007 |
Stimulation of adenosine A2A receptor inhibits LPS-induced expression of intercellular adhesion molecule 1 and production of TNF-alpha in human peripheral blood mononuclear cells.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; CD40 Antigens; Cells, Cultured; Cyclic AMP; Enzyme-Linked Immunosorbent Assay; Flavins; Flow Cytometry; Humans; Intercellular Adhesion Molecule-1; Leukocytes, Mononuclear; Lipopolysaccharide Receptors; Lipopolysaccharides; Receptor, Adenosine A2A; Triazines; Triazoles; Tumor Necrosis Factor-alpha; Xanthines | 2008 |
Anticonvulsant effect of A1 but not A2A adenosine receptors of piriform cortex in amygdala-kindled rats.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Amygdala; Analysis of Variance; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electric Stimulation; Evoked Potentials; Kindling, Neurologic; Male; Microinjections; Models, Anatomic; Phenethylamines; Rats; Rats, Sprague-Dawley; Theophylline; Triazines; Triazoles | 2007 |
Purinergic modulation of glutamate release under ischemic-like conditions in the hippocampus.
Topics: Adenosine; Adenosine Triphosphate; Analgesics; Animals; Dose-Response Relationship, Drug; Glucose; Glutamic Acid; Hippocampus; Hypoxia; In Vitro Techniques; Ischemia; Male; Phenethylamines; Purinergic Agonists; Purinergic Antagonists; Pyrimidines; Rats; Rats, Wistar; Receptors, Purinergic; Sodium Channel Blockers; Tetrodotoxin; Triazines; Triazoles; Xanthines | 2007 |
Interaction of A2A adenosine and D2 dopamine receptors modulates corticostriatal glutamatergic transmission.
Topics: Adenine; Adenosine; Animals; Cerebral Cortex; Corpus Striatum; Dopamine Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Phenethylamines; Quinpirole; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Dopamine D2; Synaptic Transmission; Triazines; Triazoles | 2007 |
Adenosine A2A receptor agonists inhibit lipopolysaccharide-induced production of tumor necrosis factor-alpha by equine monocytes.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding, Competitive; Cyclic AMP; Horses; Immunoenzyme Techniques; Lipopolysaccharides; Monocytes; Phenethylamines; Piperidines; Receptor, Adenosine A2A; Regression Analysis; Triazines; Triazoles; Tumor Necrosis Factor-alpha | 2008 |
Adenosine A(2A) receptors are required for normal BDNF levels and BDNF-induced potentiation of synaptic transmission in the mouse hippocampus.
Topics: Adenosine A2 Receptor Antagonists; Animals; Brain-Derived Neurotrophic Factor; Dose-Response Relationship, Drug; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Excitatory Postsynaptic Potentials; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Mice; Mice, Knockout; Patch-Clamp Techniques; Receptor, Adenosine A2A; Synaptic Transmission; Triazines; Triazoles | 2008 |
Activation of adenosine 2A receptors preserves structure and function of podocytes.
Topics: Adenosine A2 Receptor Agonists; Albuminuria; Animals; Diabetic Nephropathies; Mice; Mice, Inbred C57BL; Piperidines; Podocytes; Proteinuria; Purine Nucleosides; Receptors, Adenosine A2; Triazines; Triazoles | 2008 |
Up-regulation of adenosine receptors in the frontal cortex in Alzheimer's disease.
Topics: Adenylyl Cyclases; Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Cell Membrane; Colforsin; Cyclic AMP; Female; Frontal Lobe; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Middle Aged; Protein Binding; Receptors, Purinergic P1; Triazines; Triazoles; Tritium; Up-Regulation; Xanthines | 2008 |
Involvement of the adenosine A1 and A2A receptors in the antidepressant-like effect of zinc in the forced swimming test.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Aniline Compounds; Animals; Antidepressive Agents; Caffeine; Central Nervous System Stimulants; Dipyridamole; Female; Male; Mice; Motor Activity; Nucleoside Transport Proteins; Receptor, Adenosine A1; Receptor, Adenosine A2A; Swimming; Triazines; Triazoles; Xanthines; Zinc | 2008 |
Hypotensive effects of intravenously administered uridine and cytidine in conscious rats: involvement of adenosine receptors.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Animals; Antihypertensive Agents; Blood Pressure; Caffeine; Carotid Arteries; Consciousness; Cytidine; Dose-Response Relationship, Drug; Heart Rate; Hypotension; Injections, Intravenous; Injections, Intraventricular; Male; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptor, Adenosine A2A; Theobromine; Theophylline; Time Factors; Triazines; Triazoles; Uridine; Ventricular Function, Left; Ventricular Pressure; Xanthines | 2008 |
Pharmacological blockade of A2A receptors prevents dermal fibrosis in a model of elevated tissue adenosine.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Collagen; Fibrosis; Interleukin-13; Mice; Receptor, Adenosine A2A; Skin; Transforming Growth Factor beta1; Triazines; Triazoles | 2008 |
Cerebral blood flow response in adenosine 2a receptor knockout mice during transient hypoxic hypoxia.
Topics: Adrenergic alpha-2 Receptor Antagonists; Aminophylline; Animals; Blood Pressure; Cardiotonic Agents; Cerebrovascular Circulation; Female; Hyperemia; Hypoxia, Brain; Ischemic Attack, Transient; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Adrenergic, alpha-2; Triazines; Triazoles | 2008 |
Neonatal caffeine induces sex-specific developmental plasticity of the hypoxic respiratory chemoreflex in adult rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Anesthesia; Animals; Animals, Newborn; Caffeine; Carotid Body; Central Nervous System Stimulants; Female; Gene Expression; Hypoxia; Male; Neural Inhibition; Phrenic Nerve; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Dopamine D2; Reflex; Respiration; RNA, Messenger; Sex Characteristics; Triazines; Triazoles; Tyrosine 3-Monooxygenase | 2008 |
Adenosine receptor subtypes in the airways responses to 5'-adenosine monophosphate inhalation of sensitized guinea-pigs.
Topics: Adenosine Monophosphate; Administration, Inhalation; Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchodilator Agents; Dexamethasone; Dose-Response Relationship, Drug; Guinea Pigs; Immunization; Purinergic P1 Receptor Antagonists; Purines; Quinazolines; Receptors, Purinergic P1; Triazines; Triazoles; Xanthines | 2008 |
Human equilibrative nucleoside transporters 1 and 2 may be differentially modulated by A2B adenosine receptors in placenta microvascular endothelial cells from pre-eclampsia.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adult; Endothelial Cells; Equilibrative Nucleoside Transporter 1; Equilibrative-Nucleoside Transporter 2; Female; Gene Expression Regulation; Humans; Phenethylamines; Placenta; Pre-Eclampsia; Pregnancy; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Triazines; Triazoles | 2008 |
Alcohol-induced retrograde memory impairment in rats: prevention by caffeine.
Topics: Adenosine A2 Receptor Antagonists; Amnesia, Retrograde; Animals; Caffeine; Central Nervous System Depressants; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ethanol; Exploratory Behavior; Habituation, Psychophysiologic; Injections, Intraperitoneal; Male; Odorants; Pentylenetetrazole; Phosphodiesterase 5 Inhibitors; Purinones; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Recognition, Psychology; Seizures; Smell; Time Factors; Triazines; Triazoles; Wood | 2008 |
The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist.
Topics: Adenosine A2 Receptor Antagonists; Animals; Binding Sites; Crystallography, X-Ray; Humans; Ligands; Protein Binding; Protein Conformation; Receptor, Adenosine A2A; Structure-Activity Relationship; Triazines; Triazoles; Tryptophan; Turkeys | 2008 |
FGF acts as a co-transmitter through adenosine A(2A) receptor to regulate synaptic plasticity.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Cell Differentiation; Cells, Cultured; Chlorocebus aethiops; Cyclic AMP; Embryo, Mammalian; Fibroblast Growth Factors; Hippocampus; Immunoprecipitation; In Vitro Techniques; Long-Term Potentiation; Mitogen-Activated Protein Kinase Kinases; Neurites; Neurons; Patch-Clamp Techniques; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptor, Adenosine A2A; Receptors, Fibroblast Growth Factor; Synapses; Transfection; Triazines; Triazoles; Two-Hybrid System Techniques | 2008 |
Modulation of gamma oscillations by endogenous adenosine through A1 and A2A receptors in the mouse hippocampus.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Biological Clocks; Dose-Response Relationship, Drug; Evoked Potentials; Excitatory Amino Acid Agonists; Fourier Analysis; Hippocampus; Hypoxia; In Vitro Techniques; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Phenethylamines; Receptor, Adenosine A1; Receptor, Adenosine A2A; Theophylline; Thioinosine; Time Factors; Triazines; Triazoles | 2009 |
The role of adenosine A(1) receptors in mediating the inhibitory effects of low frequency stimulation of perforant path on kindling acquisition in rats.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Biophysics; Cyclic AMP; Electric Stimulation; Excitatory Postsynaptic Potentials; Hippocampus; Kindling, Neurologic; Male; Neural Inhibition; Perforant Pathway; Rats; Rats, Wistar; Receptor, Adenosine A1; Seizures; Time Factors; Triazines; Triazoles; Xanthines | 2009 |
Caffeine modulates TNF-alpha production by cord blood monocytes: the role of adenosine receptors.
Topics: Acetamides; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Antagonists; Adult; Blotting, Western; Caffeine; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Fetal Blood; Humans; Infant, Newborn; Interleukins; Lipopolysaccharides; Middle Aged; Monocytes; Purines; Quinazolines; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptor, Adenosine A3; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Triazines; Triazoles; Tumor Necrosis Factor-alpha; Xanthines | 2009 |
Adenosine A1 and A2a receptors modulate insulinemia, glycemia, and lactatemia in fetal sheep.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Blood Gas Analysis; Blood Glucose; Female; Fetus; Hydrogen-Ion Concentration; Hypoxia; Insulin; Lactates; Pregnancy; Receptor, Adenosine A1; Receptor, Adenosine A2A; Sheep; Triazines; Triazoles; Xanthines | 2009 |
Angiotensin II enhances the afferent arteriolar response to adenosine through increases in cytosolic calcium.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arterioles; Calcium; Cytosol; Kidney; Male; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Naphthyridines; Purines; Receptor, Adenosine A1; Receptor, Angiotensin, Type 1; Receptors, Adenosine A2; Triazines; Triazoles; Vasoconstriction | 2009 |
Adenosine A(1) and A(2A) receptors in mouse prefrontal cortex modulate acetylcholine release and behavioral arousal.
Topics: Acetylcholine; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Arousal; Behavior, Animal; Caffeine; Chromatography, High Pressure Liquid; Electroencephalography; Electromyography; Male; Mice; Microdialysis; Phenethylamines; Phosphodiesterase Inhibitors; Prefrontal Cortex; Receptor, Adenosine A1; Receptors, Adenosine A2; Spectrum Analysis; Triazines; Triazoles; Xanthines | 2009 |
Activation of NTS A2a adenosine receptors differentially resets baroreflex control of renal vs. adrenal sympathetic nerve activity.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adrenal Glands; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Heart Rate; Kidney; Male; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Solitary Nucleus; Sympathetic Nervous System; Theophylline; Triazines; Triazoles | 2009 |
Nitric oxide (NO) does not contribute to the generation or action of adenosine during exercise hyperaemia in rat hindlimb.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Femoral Artery; Hindlimb; Hyperemia; Isometric Contraction; Male; Muscle, Skeletal; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxygen Consumption; Physical Exertion; Rats; Rats, Wistar; Receptor, Adenosine A2A; Regional Blood Flow; S-Nitroso-N-Acetylpenicillamine; Sciatic Nerve; Time Factors; Triazines; Triazoles; Vasodilation | 2009 |
Elucidation in the rat of the role of adenosine and A2A-receptors in the hyperaemia of twitch and tetanic contractions.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Blood Pressure; Carbon Dioxide; Electric Stimulation; Femoral Artery; Hydrogen-Ion Concentration; Hyperemia; Isometric Contraction; Male; Muscle, Skeletal; Muscle, Smooth, Vascular; Oxygen; Rats; Rats, Wistar; Receptor, Adenosine A2A; Regional Blood Flow; Sciatic Nerve; Theophylline; Time Factors; Triazines; Triazoles; Vasodilation | 2009 |
Adenosine receptor antagonists improve short-term object-recognition ability of spontaneously hypertensive rats: a rodent model of attention-deficit hyperactivity disorder.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Attention Deficit Disorder with Hyperactivity; Blood Pressure; Caffeine; Disease Models, Animal; Female; Male; Memory, Short-Term; Methylphenidate; Rats; Rats, Inbred SHR; Rats, Wistar; Receptor, Adenosine A1; Receptors, Adenosine A2; Recognition, Psychology; Triazines; Triazoles; Xanthines | 2009 |
Multiple receptor subtypes and multiple mechanisms of dilation are involved in vascular network dilation caused by adenosine.
Topics: Adenosine; Animals; Arterioles; Cricetinae; Drug Antagonism; Endothelium, Vascular; Flavins; Mesocricetus; Methacholine Chloride; Nitroprusside; Purinergic P1 Receptor Antagonists; Quinazolines; Receptors, Purinergic P1; Triazines; Triazoles; Vasodilation; Vasodilator Agents | 2009 |
Cardioprotection induced by adenosine A1 receptor agonists in a cardiac cell ischemia model involves cooperative activation of adenosine A2A and A2B receptors by endogenous adenosine.
Topics: Acetamides; Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Aminopyridines; Animals; Apoptosis; Cardiotonic Agents; Cell Line; Cell Survival; Dihydropyridines; Imidazoles; Myocardial Ischemia; Phenethylamines; Purines; Rats; Triazines; Triazoles; Xanthines | 2009 |
Attenuation of gastric mucosal inflammation induced by indomethacin through activation of the A2A adenosine receptor in rats.
Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemokine CXCL1; Dinoprostone; Gastric Mucosa; Indomethacin; Inflammation; Interleukin-1beta; Male; Peroxidase; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Stomach Ulcer; Triazines; Triazoles; Tumor Necrosis Factor-alpha | 2009 |
Effect of adenosine A(2A) receptor antagonists on L-DOPA-induced hydroxyl radical formation in rat striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine A2 Receptor Antagonists; Animals; Area Under Curve; Benserazide; Catalepsy; Corpus Striatum; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Homovanillic Acid; Hydroxyl Radical; Levodopa; Male; Microdialysis; Rats; Rats, Wistar; Time Factors; Triazines; Triazoles; Xanthines | 2009 |
A2A adenosine receptor antagonists protect the striatum against rotenone-induced neurotoxicity.
Topics: Action Potentials; Adenine; Adenosine A2 Receptor Antagonists; Animals; Cerebral Cortex; Corpus Striatum; Dose-Response Relationship, Drug; In Vitro Techniques; Insecticides; Male; Neurons; Rats; Rats, Wistar; Rotenone; Time Factors; Triazines; Triazoles | 2009 |
The adenosine A2A receptor antagonist ZM241385 enhances neuronal survival after oxygen-glucose deprivation in rat CA1 hippocampal slices.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Astrocytes; Blotting, Western; Brain Ischemia; Cell Hypoxia; Cell Survival; Coloring Agents; Excitatory Postsynaptic Potentials; Glial Fibrillary Acidic Protein; Glucose; Hippocampus; Immunohistochemistry; In Vitro Techniques; Male; Neurons; Neuroprotective Agents; Oxygen; Phenethylamines; Propidium; Pyrazoles; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Staining and Labeling; Time Factors; Triazines; Triazoles | 2009 |
Adenosine A1 receptors presynaptically modulate excitatory synaptic input onto subiculum neurons.
Topics: Action Potentials; Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Central Nervous System Agents; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Membrane Potentials; Neurons; Presynaptic Terminals; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptors, Adenosine A2; Synapses; Synaptic Transmission; Triazines; Triazoles; Xanthines | 2009 |
Differential regulation of HIF-1alpha isoforms in murine macrophages by TLR4 and adenosine A(2A) receptor agonists.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Cells, Cultured; Drug Combinations; Female; Gene Expression Regulation; Genes, Reporter; Hypoxia-Inducible Factor 1, alpha Subunit; Lipopolysaccharides; Luciferases, Renilla; Macrophages, Peritoneal; Mice; Mice, Congenic; Mice, Inbred C57BL; NF-kappa B; Nitriles; Phenethylamines; Protein Isoforms; Purinergic P1 Receptor Agonists; RNA, Messenger; Sulfones; Toll-Like Receptor 4; Transfection; Triazines; Triazoles; Vascular Endothelial Growth Factor A | 2009 |
Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation.
Topics: Adenosine A2 Receptor Antagonists; Animals; Bile Ducts; Brain-Derived Neurotrophic Factor; Cannabidiol; Chronic Disease; Cognition; Cognition Disorders; Cyclooxygenase 2; Disease Models, Animal; Female; Gait Disorders, Neurologic; Hepatic Encephalopathy; Ligation; Liver Diseases; Mice; Mice, Inbred Strains; Motor Activity; Receptor, Adenosine A2A; Receptors, Tumor Necrosis Factor, Type I; RNA, Messenger; Treatment Outcome; Triazines; Triazoles | 2009 |
Region-specific neuroprotective effect of ZM 241385 towards glutamate uptake inhibition in cultured neurons.
Topics: Adenosine A2 Receptor Antagonists; Animals; Binding, Competitive; Biological Transport; Biomimetics; Blotting, Western; Cells, Cultured; Cerebral Cortex; Dicarboxylic Acids; Female; Gene Expression Regulation; Glutamic Acid; Neostriatum; Neurons; Neuroprotective Agents; Organ Specificity; Pregnancy; Pyrrolidines; Rats; Receptor, Adenosine A2A; Substrate Specificity; Triazines; Triazoles | 2009 |
Adenosine A2A receptors enable the synaptic effects of cannabinoid CB1 receptors in the rodent striatum.
Topics: Action Potentials; Animals; Benzoxazines; Biophysics; Calcium; Calcium Channel Blockers; Cerebral Cortex; Corpus Striatum; Electric Stimulation; Embryo, Mammalian; Excitatory Amino Acid Agonists; Female; Glycine; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Mice; Mice, Knockout; Morpholines; N-Methylaspartate; Naphthalenes; Neurons; Phenylacetates; Piperidines; Pregnancy; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Adenosine A2; Synapses; Triazines; Triazoles | 2009 |
2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a new scaffold to obtain potent and selective human A3 adenosine receptor antagonists: new insights into the receptor-antagonist recognition.
Topics: Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Antagonists; Amino Acid Sequence; Animals; CHO Cells; Cricetinae; Cricetulus; Humans; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Protein Binding; Pyrazoles; Pyrimidines; Pyrimidinones; Receptor, Adenosine A2A; Receptor, Adenosine A3; Substrate Specificity; Triazines; Triazoles | 2009 |
Homology modelling of the human adenosine A2B receptor based on X-ray structures of bovine rhodopsin, the beta2-adrenergic receptor and the human adenosine A2A receptor.
Topics: Animals; Cattle; Humans; Models, Molecular; Molecular Structure; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Receptor, Adenosine A2B; Receptors, Adrenergic, beta-2; Rhodopsin; Triazines; Triazoles; X-Rays | 2009 |
Inhibition of the adenosine2A receptor-epoxyeicosatrienoic acid pathway renders Dahl salt-resistant rats hypertensive.
Topics: Adrenergic alpha-2 Receptor Antagonists; Amides; Animals; Blood Pressure; Drinking; Eicosanoids; Hydroxyeicosatetraenoic Acids; Hypertension, Renal; Male; Natriuresis; Oxidoreductases; Rats; Rats, Inbred Dahl; Receptors, Adrenergic, alpha-2; Sodium Chloride, Dietary; Triazines; Triazoles | 2009 |
Human follicular lymphoma CD39+-infiltrating T cells contribute to adenosine-mediated T cell hyporesponsiveness.
Topics: Adenosine; Adenosine Triphosphate; Antigens, CD; Apyrase; CD8-Positive T-Lymphocytes; Clonal Anergy; Humans; Interferon-gamma; Interleukin-2; Lymphocytes, Tumor-Infiltrating; Lymphoma, Follicular; Neuroprotective Agents; Pyrimidines; Receptors, Purinergic P1; T-Lymphocytes, Regulatory; Triazines; Triazoles | 2009 |
Role of adenosine A2 receptors in regulation of cerebral blood flow during induced hypotension.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Cerebrovascular Circulation; Dipyridamole; Hypotension; Male; Mice; Mice, Knockout; Phenethylamines; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Triazines; Triazoles; Vasodilation; Vasodilator Agents | 2010 |
DNA methylation regulates adenosine A(2A) receptor cell surface expression levels.
Topics: Azacitidine; Cell Line; Chromatin Immunoprecipitation; DNA Methylation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; HeLa Cells; Humans; Immunoprecipitation; Methyl-CpG-Binding Protein 2; Neuroblastoma; Protein Binding; Radioligand Assay; Receptor, Adenosine A2A; Receptors, Cell Surface; RNA, Messenger; S-Adenosylmethionine; Time Factors; Triazines; Triazoles; Tritium | 2010 |
Blockade of adenosine A2A receptor counteracts neuropeptide-S-induced hyperlocomotion in mice.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Humans; Male; Mice; Mice, Inbred Strains; Motor Activity; Neuropeptides; Triazines; Triazoles | 2010 |
Lipopolysaccharide and TNF-alpha modify adenosine A(2A) receptor expression and function in equine monocytes.
Topics: Adenosine A2 Receptor Agonists; Animals; Animals, Newborn; Base Sequence; DNA Primers; Horse Diseases; Horses; Humans; In Vitro Techniques; Lipopolysaccharides; Mice; Monocytes; Piperidines; Radioligand Assay; Receptor, Adenosine A2A; Recombinant Proteins; RNA, Messenger; Systemic Inflammatory Response Syndrome; Triazines; Triazoles; Tumor Necrosis Factor-alpha | 2010 |
Predicted 3D structures for adenosine receptors bound to ligands: comparison to the crystal structure.
Topics: Binding Sites; Crystallization; Humans; Models, Molecular; Molecular Structure; Monte Carlo Method; Protein Conformation; Receptor, Adenosine A2A; Triazines; Triazoles | 2010 |
Adenosine inhibits paraventricular pre-sympathetic neurons through ATP-dependent potassium channels.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adenosine; Analgesics; Animals; Bicuculline; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glyburide; Guanosine Diphosphate; In Vitro Techniques; KATP Channels; Male; Membrane Potentials; Neurons; Paraventricular Hypothalamic Nucleus; Patch-Clamp Techniques; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Sodium Channel Blockers; Tetrodotoxin; Thionucleotides; Tolbutamide; Triazines; Triazoles; Xanthines | 2010 |
The role of adenosine receptors in regulating production of tumour necrosis factor-alpha and chemokines by human lung macrophages.
Topics: Acetamides; Cells, Cultured; Chemokines; Female; Humans; Lipopolysaccharides; Lung; Macrophages, Alveolar; Male; Middle Aged; Protein Subunits; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Quinazolines; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; Triazines; Triazoles; Tumor Necrosis Factor-alpha | 2010 |
Adenosine A(2)A receptor but not HIF-1 mediates Tyrosine hydroxylase induction in hypoxic PC12 cells.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; Cell Hypoxia; Cyclic AMP Response Element-Binding Protein; DNA; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Mutation; PC12 Cells; Phenethylamines; Promoter Regions, Genetic; Rats; Receptor, Adenosine A2A; RNA, Messenger; Signal Transduction; Transcription, Genetic; Transfection; Triazines; Triazoles; Tyrosine 3-Monooxygenase | 2010 |
Ligand binding and subtype selectivity of the human A(2A) adenosine receptor: identification and characterization of essential amino acid residues.
Topics: Adenosine A2 Receptor Antagonists; Amino Acid Substitution; Binding Sites; Cell Line; Humans; Ligands; Models, Molecular; Mutagenesis; Mutation, Missense; Protein Binding; Receptor, Adenosine A2A; Triazines; Triazoles | 2010 |
Priming of signal transducer and activator of transcription proteins for cytokine-triggered polyubiquitylation and degradation by the A 2A adenosine receptor.
Topics: Animals; Blotting, Western; Cells, Cultured; Cytokines; Down-Regulation; Humans; Hydrolysis; Immunoprecipitation; Mice; Mice, Knockout; Phosphorylation; Receptors, Adenosine A2; STAT Transcription Factors; Triazines; Triazoles; Ubiquitination | 2010 |
Acadesine inhibits tissue factor induction and thrombus formation by activating the phosphoinositide 3-kinase/Akt signaling pathway.
Topics: Adenosine A2 Receptor Antagonists; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apolipoproteins E; Atherosclerosis; Blood Coagulation; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Fibrinolytic Agents; Humans; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocytes; NF-kappa B; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyrimidines; Receptor, Adenosine A2A; Ribonucleosides; RNA, Messenger; Sepsis; Signal Transduction; Thromboplastin; Transcription Factor AP-1; Triazines; Triazoles; Up-Regulation; Venous Thrombosis | 2010 |
Adenosine activates a2b receptors and enhances chloride secretion in kidney inner medullary collecting duct cells.
Topics: Adenosine; Animals; Cell Line; Chlorides; Cystic Fibrosis Transmembrane Conductance Regulator; Kidney Medulla; Kidney Tubules, Collecting; Pyrazoles; Pyrimidines; Rats; Receptor, Adenosine A2B; Triazines; Triazoles; Xanthines | 2010 |
Adenosine A(2) receptors modulate tubuloglomerular feedback.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Arterioles; Blood Pressure; Feedback, Physiological; Kidney Glomerulus; Kidney Tubules; Male; Microcirculation; Perfusion; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Renal Circulation; Triazines; Triazoles; Vasoconstriction; Vasodilation; Xanthines | 2010 |
Activation of adenosine A2A receptor attenuates inflammatory response in a rat model of small-for-size liver transplantation.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Alanine Transaminase; Animals; Chemokine CXCL2; Cytokines; Enzyme-Linked Immunosorbent Assay; Inflammation; Intercellular Adhesion Molecule-1; Liver; Liver Transplantation; Male; NF-kappa B; Organ Size; Peroxidase; Phenethylamines; Phosphorylation; Rats; Rats, Inbred Lew; Receptor, Adenosine A2A; Triazines; Triazoles; Tumor Necrosis Factor-alpha | 2010 |
Peripheral adenosine A2A receptors are involved in carrageenan-induced mechanical hyperalgesia in mice.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Carrageenan; Female; Ganglia, Spinal; Hyperalgesia; Inflammation; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mice; Mice, Knockout; Pain; Pain Threshold; Phenethylamines; Receptor, Adenosine A2A; Sex Characteristics; Triazines; Triazoles | 2010 |
Cooperative cardioprotection through adenosine A1 and A2A receptor agonism in ischemia-reperfused isolated mouse heart.
Topics: Acetamides; Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Blood Pressure; Cardiotonic Agents; Drug Synergism; In Vitro Techniques; Male; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardial Contraction; Myocardial Reperfusion Injury; Phosphorylation; Purines; Receptor, Adenosine A2A; Triazines; Triazoles; Xanthines | 2010 |
GPCR structure and activation: an essential role for the first extracellular loop in activating the adenosine A2B receptor.
Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Amino Acid Sequence; Aminopyridines; Gene Expression Regulation; Humans; Models, Molecular; Molecular Structure; Mutagenesis, Site-Directed; Protein Conformation; Receptor, Adenosine A2B; Saccharomyces cerevisiae; Triazines; Triazoles | 2011 |
Static magnetic field exposure reproduces cellular effects of the Parkinson's disease drug candidate ZM241385.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine Triphosphate; Analysis of Variance; Animals; Blotting, Western; Calcium; Cell Proliferation; Cyclic AMP; Iron; Magnetic Field Therapy; Magnetics; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurites; Parkinson Disease; PC12 Cells; Phenethylamines; Phosphorylation; Rats; Receptor, Adenosine A2A; Triazines; Triazoles | 2010 |
Abnormal calcium handling in atrial fibrillation is linked to up-regulation of adenosine A2A receptors.
Topics: Adenosine A2 Receptor Antagonists; Aged; Atrial Fibrillation; Blotting, Western; Calcium; Calcium Channels, L-Type; Calcium Signaling; Female; Humans; Male; Middle Aged; Myocytes, Cardiac; Real-Time Polymerase Chain Reaction; Receptor, Adenosine A2A; RNA, Messenger; Sarcoplasmic Reticulum; Triazines; Triazoles; Up-Regulation | 2011 |
Presynaptic facilitatory adenosine A2A receptors mediate fade induced by neuromuscular relaxants that exhibit anticholinesterase activity.
Topics: Acetylcholine; Animals; Atracurium; Cholinesterase Inhibitors; Diaphragm; Electric Stimulation; Hexamethonium; Male; Muscle Contraction; Neuromuscular Agents; Neuromuscular Junction; Pancuronium; Phrenic Nerve; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptor, Muscarinic M2; Receptors, Nicotinic; Receptors, Presynaptic; Synaptic Transmission; Triazines; Triazoles; Tubocurarine; Vecuronium Bromide | 2011 |
A(2A) adenosine receptor binding parameters in platelets from patients affected by pathological gambling.
Topics: Adult; Blood Platelets; Case-Control Studies; Female; Gambling; Humans; Kinetics; Male; Radioligand Assay; Radionuclide Imaging; Receptor, Adenosine A2A; Triazines; Triazoles; Tritium | 2011 |
Structure of an agonist-bound human A2A adenosine receptor.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Binding Sites; Crystallography, X-Ray; Humans; Hydrogen Bonding; Ligands; Models, Molecular; Opsins; Protein Conformation; Protein Structure, Secondary; Receptor, Adenosine A2A; Rhodopsin; Triazines; Triazoles | 2011 |
Adenosine A(2A) receptor activation prevents progressive kidney fibrosis in a model of immune-associated chronic inflammation.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Anti-Inflammatory Agents; Autoantibodies; Disease Models, Animal; Extracellular Matrix Proteins; Fibrosis; Glomerulonephritis; Inflammation Mediators; Kidney; Macrophages; Male; Phenethylamines; Rats; Rats, Inbred WKY; Receptor, Adenosine A2A; Severity of Illness Index; Time Factors; Triazines; Triazoles | 2011 |
Adenosine A2(A) receptor modulates the oxidative stress response of primed polymorphonuclear leukocytes after parabolic flight.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Adult; Gene Expression Regulation; Gravity, Altered; Humans; Hydrogen Peroxide; Immunologic Factors; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxidative Stress; Receptors, Adenosine A2; RNA, Messenger; Triazines; Triazoles; Tumor Necrosis Factor-alpha; Vasodilator Agents | 2011 |
Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Crystallography, X-Ray; Drug Inverse Agonism; Humans; Ligands; Models, Molecular; Molecular Conformation; Receptor, Adenosine A2A; Triazines; Triazoles | 2011 |
Biophysical mapping of the adenosine A2A receptor.
Topics: Adenosine A2 Receptor Antagonists; Binding Sites; Drug Design; Ligands; Models, Molecular; Mutation; Pyrimidines; Receptor, Adenosine A2A; Small Molecule Libraries; Triazines; Triazoles; Xanthines | 2011 |
The effect of A(2A) adenosine receptor activation on C-C chemokine receptor 7 expression in human THP1 macrophages during inflammation.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Cell Line; Cell Movement; Chemokine CCL21; Humans; Inflammation; Macrophages; Phenethylamines; Receptors, Adenosine A2; Receptors, CCR7; RNA, Messenger; Triazines; Triazoles | 2012 |
mGlu5 and adenosine A2A receptor interactions regulate the conditioned effects of cocaine.
Topics: Analysis of Variance; Animals; Autoradiography; Brain; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Drug Interactions; Excitatory Amino Acid Antagonists; Iodine Isotopes; Locomotion; Male; Mice; Mice, Knockout; Protein Binding; Pyridines; Radionuclide Imaging; Receptor, Adenosine A2A; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Thiazoles; Time Factors; Triazines; Triazoles | 2012 |
Effect of adenosine A(2A) receptor antagonists and L-DOPA on hydroxyl radical, glutamate and dopamine in the striatum of 6-OHDA-treated rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine A2 Receptor Antagonists; Animals; Benserazide; Caffeine; Dopamine; Glutamic Acid; Hydroxyl Radical; Levodopa; Male; Microdialysis; Neostriatum; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Receptor, Adenosine A2A; Triazines; Triazoles | 2012 |
Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine.
Topics: Adenosine A2 Receptor Agonists; Amino Acid Motifs; Amino Acid Sequence; Amino Acid Substitution; Binding Sites; Caffeine; Crystallography, X-Ray; HEK293 Cells; Humans; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Protein Stability; Protein Structure, Tertiary; Receptor, Adenosine A2A; Surface Properties; Triazines; Triazoles; Xanthines | 2011 |
Computational study of the binding modes of caffeine to the adenosine A2A receptor.
Topics: Amino Acid Substitution; Caffeine; Entropy; Humans; Lipid Bilayers; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Protein Binding; Protein Structure, Tertiary; Receptor, Adenosine A2A; Triazines; Triazoles | 2011 |
Functional interaction between purinergic receptors: effect of ligands for A2A and P2Y12 receptors on P2Y1 receptor function.
Topics: Adenosine A2 Receptor Antagonists; Calcium Signaling; Cell Line, Tumor; Gene Expression Regulation; HEK293 Cells; Humans; Intracellular Space; Ligands; Protein Binding; Purinergic P2Y Receptor Agonists; Purinergic P2Y Receptor Antagonists; Receptor, Adenosine A2A; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Triazines; Triazoles | 2011 |
Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: role for the adenosine A(2A) receptor.
Topics: Acute Lung Injury; Adenosine A2 Receptor Antagonists; Animals; Anti-Inflammatory Agents; Bone Marrow Cells; Bronchoalveolar Lavage Fluid; Cannabidiol; Cannabinoids; Capillary Permeability; Chemokines; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Leukocytes; Male; Mice; Mice, Inbred C57BL; Peroxidase; Receptor, Adenosine A2A; Triazines; Triazoles | 2012 |
The effect of adenosine A(2A) receptor antagonists on hydroxyl radical, dopamine, and glutamate in the striatum of rats with altered function of VMAT2.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine A2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Animals; Caffeine; Corpus Striatum; Dopamine; Dopamine Agents; Extracellular Space; Glutamic Acid; Homovanillic Acid; Hydroxyl Radical; Levodopa; Male; Microdialysis; Oxidative Stress; Rats; Rats, Wistar; Reserpine; Triazines; Triazoles; Vesicular Monoamine Transport Proteins | 2012 |
Suppression of bladder overactivity by adenosine A2A receptor antagonist in a rat model of Parkinson disease.
Topics: Adenosine A2 Receptor Antagonists; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Parkinson Disease; Rats; Rats, Sprague-Dawley; Triazines; Triazoles; Urinary Bladder, Overactive; Urination | 2012 |
mGlu5R promotes glutamate AMPA receptor phosphorylation via activation of PKA/DARPP-32 signaling in striatopallidal medium spiny neurons.
Topics: Animals; Corpus Striatum; Cyclic AMP-Dependent Protein Kinases; Dopamine and cAMP-Regulated Phosphoprotein 32; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Phosphorylation; Purinergic P1 Receptor Antagonists; Pyridines; Receptor, Adenosine A2A; Receptor, Metabotropic Glutamate 5; Receptors, AMPA; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Metabotropic Glutamate; Resorcinols; Signal Transduction; Triazines; Triazoles | 2013 |
Effect of adenosine A2A receptor antagonist ZM241385 on amygdala-kindled seizures and progression of amygdala kindling.
Topics: Adenosine A2 Receptor Antagonists; Amygdala; Animals; Dose-Response Relationship, Drug; Male; Rats; Rats, Wistar; Receptor, Adenosine A2A; Seizures; Treatment Outcome; Triazines; Triazoles | 2012 |
A novel dihydro-pyrazolo(3,4d)(1,2,4)triazolo(1,5a)pyrimidin-4-one (AJ23) is an antagonist at adenosine A(1) receptors and enhances consolidation of step-down avoidance.
Topics: Adenosine; Analysis of Variance; Animals; Avoidance Learning; CA1 Region, Hippocampal; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Electric Stimulation; Excitatory Postsynaptic Potentials; HEK293 Cells; Heterocyclic Compounds, 3-Ring; Humans; In Vitro Techniques; Inhibition, Psychological; Male; Protein Binding; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Wistar; Reaction Time; Retention, Psychology; Structure-Activity Relationship; Triazines; Triazoles; Tritium; Xanthines | 2012 |
Pharmacological blockade of adenosine A2A receptors diminishes scarring.
Topics: Adenosine A2 Receptor Antagonists; Animals; Blotting, Western; Cicatrix; Collagen; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Receptor, Adenosine A2A; Reverse Transcriptase Polymerase Chain Reaction; Triazines; Triazoles; Wound Healing | 2012 |
The mechanism of beta-adrenergic preconditioning: roles for adenosine and ROS during triggering and mediation.
Topics: Adenosine; Animals; Ethanolamines; Extracellular Signal-Regulated MAP Kinases; Formoterol Fumarate; Ischemic Preconditioning, Myocardial; Isoproterenol; Myocardial Infarction; Phosphatidylinositol 3-Kinases; Potassium Channels; Protein Kinase C; Proto-Oncogene Proteins c-akt; Rats; Reactive Oxygen Species; Receptors, Adrenergic, beta; Receptors, Purinergic P1; Triazines; Triazoles | 2012 |
Structural basis for allosteric regulation of GPCRs by sodium ions.
Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Allosteric Regulation; Cholesterol; Crystallography, X-Ray; Cytochrome b Group; Escherichia coli Proteins; HEK293 Cells; Humans; Hydrogen Bonding; Ligands; Lipid Bilayers; Lipids; Models, Molecular; Protein Conformation; Protein Engineering; Protein Structure, Secondary; Receptor, Adenosine A2A; Recombinant Fusion Proteins; Sodium; Triazines; Triazoles; Water | 2012 |
Effects of ethanolic extract and naphthoquinones obtained from the bulbs of Cipura paludosa on short-term and long-term memory: involvement of adenosine A₁ and A₂A receptors.
Topics: Animals; Avoidance Learning; Brazil; Caffeine; Ethanol; Furans; Iridaceae; Male; Memory, Long-Term; Memory, Short-Term; Mice; Naphthoquinones; Plant Extracts; Plant Roots; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptors, Adenosine A2; Triazines; Triazoles; Xanthines | 2013 |
Adenosine A2A receptor modulates vascular response in soluble epoxide hydrolase-null mice through CYP-epoxygenases and PPARγ.
Topics: 8,11,14-Eicosatrienoic Acid; Adamantane; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Benzamides; Benzoates; Butyrates; Enzyme Inhibitors; Epoxide Hydrolases; Female; Gene Silencing; Lauric Acids; Male; Mice; NG-Nitroarginine Methyl Ester; Oxygenases; Phenethylamines; Phenylurea Compounds; PPAR gamma; Pyridines; Pyrimidines; Receptor, Adenosine A2A; Triazines; Triazoles; Urea; Vasodilation; Vasodilator Agents | 2013 |
Effects of oxygen and glucose deprivation on synaptic transmission in rat dentate gyrus: role of A2A adenosine receptors.
Topics: Animals; Cell Proliferation; Dentate Gyrus; Doublecortin Protein; Excitatory Postsynaptic Potentials; Glucose; Male; Organ Culture Techniques; Oxygen; Rats; Rats, Wistar; Receptor, Adenosine A2A; Synaptic Transmission; Triazines; Triazoles | 2013 |
High-intensity swimming exercise reduces neuropathic pain in an animal model of complex regional pain syndrome type I: evidence for a role of the adenosinergic system.
Topics: Adenine; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adenosine Deaminase Inhibitors; Animals; Caffeine; Exercise Therapy; Hyperalgesia; Male; Mice; Naloxone; Narcotic Antagonists; Neuralgia; Neurons; Reflex Sympathetic Dystrophy; Swimming; Triazines; Triazoles; Xanthines | 2013 |
Crystallogenesis of adenosine A(2A) receptor-T4 lysozyme fusion protein: a practical route for the structure.
Topics: Adenosine A2 Receptor Antagonists; Animals; Humans; Models, Biological; Muramidase; Protein Binding; Protein Conformation; Receptor, Adenosine A2A; Receptors, G-Protein-Coupled; Recombinant Fusion Proteins; Triazines; Triazoles | 2013 |
Adenosine 2A receptor modulates inflammation and phenotype in experimental abdominal aortic aneurysms.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Aortic Aneurysm, Abdominal; CD4-Positive T-Lymphocytes; Cytokines; Humans; Inflammation; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Pancreatic Elastase; Phenethylamines; Phenotype; Receptors, Adenosine A2; Triazines; Triazoles | 2013 |
Adenosine transporter ENT1 regulates the acquisition of goal-directed behavior and ethanol drinking through A2A receptor in the dorsomedial striatum.
Topics: Alcohol Drinking; Analysis of Variance; Animals; beta-Galactosidase; Choice Behavior; Conditioning, Operant; Corpus Striatum; CREB-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Equilibrative Nucleoside Transporter 1; Gene Expression Regulation; Goals; Green Fluorescent Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Receptor, Adenosine A2A; Reinforcement Schedule; Signal Transduction; Sucrose; Sweetening Agents; Triazines; Triazoles | 2013 |
Antagonist binding and induced conformational dynamics of GPCR A2A adenosine receptor.
Topics: Adenosine A2 Receptor Antagonists; Animals; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Conformation; Purines; Rats; Receptor, Adenosine A2A; Thermodynamics; Triazines; Triazoles | 2013 |
A3 adenosine receptor: homology modeling and 3D-QSAR studies.
Topics: Adenosine A3 Receptor Antagonists; Amino Acid Sequence; Binding Sites; Drug Discovery; Humans; Intracellular Signaling Peptides and Proteins; Models, Molecular; Molecular Dynamics Simulation; Protein Binding; Quantitative Structure-Activity Relationship; Receptor, Adenosine A2A; Receptor, Adenosine A3; Triazines; Triazoles | 2013 |
Novel adenosine A(2A) receptor ligands: a synthetic, functional and computational investigation of selected literature adenosine A(2A) receptor antagonists for extending into extracellular space.
Topics: Adenosine A2 Receptor Antagonists; Binding Sites; Humans; Hydrogen Bonding; Ligands; Molecular Docking Simulation; Protein Binding; Protein Structure, Tertiary; Receptor, Adenosine A2A; Triazines; Triazoles | 2013 |
Adenosine A(2A) receptors regulate the activity of sleep regulatory GABAergic neurons in the preoptic hypothalamus.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; GABAergic Neurons; Hypothalamus; Infusions, Intraventricular; Male; Microinjections; Models, Animal; Phenethylamines; Preoptic Area; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Sleep; Triazines; Triazoles | 2013 |
Functional interaction between pre-synaptic α6β2-containing nicotinic and adenosine A2A receptors in the control of dopamine release in the rat striatum.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Corpus Striatum; Dopamine; Gene Expression Regulation; Male; Motor Skills; Nicotine; Phenethylamines; Presynaptic Terminals; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Nicotinic; Synaptosomes; Triazines; Triazoles | 2013 |
Revisiting a receptor-based pharmacophore hypothesis for human A(2A) adenosine receptor antagonists.
Topics: Adenosine A2 Receptor Antagonists; Drug Design; Humans; Molecular Docking Simulation; Protein Conformation; Quantitative Structure-Activity Relationship; Receptor, Adenosine A2A; Static Electricity; Triazines; Triazoles | 2013 |
Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: a role for A2A receptors.
Topics: Animals; Brain; Cannabidiol; Cardiovirus Infections; Cell Adhesion; Cells, Cultured; Chemokine CCL2; Chemokine CCL5; Disease Models, Animal; Endothelial Cells; Inflammation; Interleukin-1beta; Mice; Motor Activity; Multiple Sclerosis; Receptor, Adenosine A2A; Triazines; Triazoles; Vascular Cell Adhesion Molecule-1 | 2013 |
Antagonism of adenosine A2A receptor expressed by lung adenocarcinoma tumor cells and cancer associated fibroblasts inhibits their growth.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Adenosine A2 Receptor Antagonists; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Fibroblasts; Heterografts; Humans; Lung Neoplasms; Mice, Nude; Pyrimidines; Receptor, Adenosine A2A; Triazines; Triazoles | 2013 |
Modulation of A₂a receptor antagonist on D₂ receptor internalization and ERK phosphorylation.
Topics: Adenosine A2 Receptor Antagonists; Animals; Arrestins; beta-Arrestins; Bioluminescence Resonance Energy Transfer Techniques; Cells, Cultured; Corpus Striatum; Extracellular Signal-Regulated MAP Kinases; HEK293 Cells; Humans; Neurons; Phosphorylation; Protein Multimerization; Quinpirole; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Dopamine D2; src-Family Kinases; Triazines; Triazoles | 2013 |
A(2A) adenosine receptors and Parkinson's disease severity.
Topics: Adenosine A2 Receptor Agonists; Aged; Disease Progression; Dose-Response Relationship, Drug; Dyskinesias; Female; Humans; Lymphocytes; Male; Middle Aged; Parkinson Disease; Protein Binding; Receptor, Adenosine A2A; Statistics, Nonparametric; Triazines; Triazoles; Tritium | 2014 |
The stimulation of adenosine A2A receptors ameliorates the pathological phenotype of fibroblasts from Niemann-Pick type C patients.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Calcium; Case-Control Studies; Cell Line; Cholesterol; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electron Transport Complex IV; Extracellular Signal-Regulated MAP Kinases; Female; Fibroblasts; Humans; Lysosomes; Male; Membrane Potential, Mitochondrial; Mitochondria; Niemann-Pick Disease, Type C; Phenethylamines; Phenotype; Receptor, Adenosine A2A; Triazines; Triazoles | 2013 |
Nucleus tractus solitarii A(2a) adenosine receptors inhibit cardiopulmonary chemoreflex control of sympathetic outputs.
Topics: Adenosine; Adrenal Glands; Animals; Biguanides; Blood Pressure; Chemoreceptor Cells; Heart Atria; Heart Conduction System; Heart Rate; Hypotension; Kidney; Lumbosacral Region; Male; Microinjections; Models, Neurological; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Reflex; Serotonin 5-HT3 Receptor Agonists; Solitary Nucleus; Sympathetic Nervous System; Triazines; Triazoles | 2014 |
Paradoxical neostigmine-induced TOFfade: on the role of presynaptic cholinergic and adenosine receptors.
Topics: Animals; Atropine; Cholinesterase Inhibitors; Diamines; Diaphragm; In Vitro Techniques; Male; Muscarinic Antagonists; Neostigmine; Phrenic Nerve; Pirenzepine; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Cholinergic; Receptors, Presynaptic; Receptors, Purinergic P1; Synaptic Transmission; Triazines; Triazoles | 2014 |
Protective mechanisms of adenosine 5'-monophosphate in platelet activation and thrombus formation.
Topics: Adenosine A2 Receptor Agonists; Adenosine Monophosphate; Animals; Blood Platelets; CD40 Ligand; Cells, Cultured; Crotalid Venoms; Cyclic Nucleotide Phosphodiesterases, Type 3; Disease Models, Animal; Humans; Lasers; Lectins, C-Type; Mesenteric Veins; Mice; Molecular Targeted Therapy; P-Selectin; Peptide Fragments; Photochemical Processes; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Receptor, Adenosine A2A; Rose Bengal; Stereoisomerism; Thrombosis; Triazines; Triazoles | 2014 |
Mechanisms involved in increased sensitivity to adenosine A(2A) receptor activation and hypoxia-induced vasodilatation in porcine coronary arteries.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Coronary Vessels; Cyclic AMP; Dinoprost; HSP20 Heat-Shock Proteins; Hypoxia; In Vitro Techniques; Oxygen; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Swine; Triazines; Triazoles; Vasodilation | 2014 |
Reduced striatal adenosine A2A receptor levels define a molecular subgroup in schizophrenia.
Topics: Actins; Adenosine A1 Receptor Antagonists; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Cell Membrane; DNA Methylation; Female; Humans; Lewy Body Disease; Male; Middle Aged; Positron-Emission Tomography; Postmortem Changes; Psychiatric Status Rating Scales; Putamen; Receptor, Adenosine A2A; Schizophrenia; Triazines; Triazoles; Tritium; Xanthines | 2014 |
Extracellular adenosine controls NKT-cell-dependent hepatitis induction.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Cells, Cultured; Concanavalin A; Flow Cytometry; Galactosylceramides; Hepatitis, Animal; Interferon-gamma; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout; Natural Killer T-Cells; Phenethylamines; Receptor, Adenosine A2A; Triazines; Triazoles; Tumor Necrosis Factor-alpha | 2014 |
NF-κB enhances hypoxia-driven T-cell immunosuppression via upregulation of adenosine A(2A) receptors.
Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Cell Hypoxia; Cell Survival; Cells, Cultured; Cobalt; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunosuppression Therapy; Isoquinolines; NF-kappa B; Receptor, Adenosine A2A; Signal Transduction; Sulfites; Sulfonamides; T-Lymphocytes; Triazines; Triazoles; Up-Regulation | 2014 |
Binding kinetics of ZM241385 derivatives at the human adenosine A2A receptor.
Topics: Adenosine A2 Receptor Antagonists; Binding Sites; Dose-Response Relationship, Drug; Humans; Kinetics; Molecular Structure; Receptor, Adenosine A2A; Structure-Activity Relationship; Triazines; Triazoles | 2014 |
Chlorogenic acid inhibits human platelet activation and thrombus formation.
Topics: Adenine; Adenosine Triphosphate; Animals; Binding Sites; Bleeding Time; Cell Communication; Cell Line; Cell Survival; Chlorogenic Acid; Collagen; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Hemorheology; Humans; Inflammation Mediators; Leukocytes; Mice; Models, Molecular; P-Selectin; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Receptor, Adenosine A2A; Thrombosis; Triazines; Triazoles | 2014 |
The plant hormone zeatin riboside inhibits T lymphocyte activity via adenosine A2A receptor activation.
Topics: Animals; Antigens, CD; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cells, Cultured; Cyclic AMP; Cytokines; Female; Immunomodulation; Isopentenyladenosine; Leukocytosis; Mice; Mice, Inbred C57BL; Plant Growth Regulators; Receptor, Adenosine A2A; Triazines; Triazoles | 2015 |
Histamine H3 receptor activation counteracts adenosine A2A receptor-mediated enhancement of depolarization-evoked [3H]-GABA release from rat globus pallidus synaptosomes.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Biphenyl Compounds; gamma-Aminobutyric Acid; Globus Pallidus; Histamine Agonists; Histamine H3 Antagonists; Imidazoles; Male; Membrane Potentials; Nitriles; Phenethylamines; Piperidines; Potassium; Pyrrolidines; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Histamine H3; Synaptosomes; Thiourea; Triazines; Triazoles; Tritium | 2014 |
Helium preconditioning protects mouse liver against ischemia and reperfusion injury through the PI3K/Akt pathway.
Topics: Adenosine A2 Receptor Antagonists; Animals; Apoptosis; Disease Models, Animal; Helium; Ischemic Preconditioning; Liver; Liver Transplantation; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Reperfusion Injury; Signal Transduction; Transplantation Conditioning; Triazines; Triazoles; Warm Ischemia | 2014 |
Diadenosine diphosphate (Ap₂A) delays neutrophil apoptosis via the adenosine A2A receptor and cAMP/PKA pathway.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine A2 Receptor Antagonists; Apoptosis; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dideoxyadenosine; Dinucleoside Phosphates; Humans; Neutrophils; Pyrazoles; Pyrimidines; Receptor, Adenosine A2A; Thionucleotides; Triazines; Triazoles | 2014 |
Structural and energetic effects of A2A adenosine receptor mutations on agonist and antagonist binding.
Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Binding Sites; Humans; Ligands; Mutant Proteins; Mutation; Receptor, Adenosine A2A; Thermodynamics; Triazines; Triazoles | 2014 |
Expression of CD73 and A2A receptors in cells from subjects with obesity and type 2 diabetes mellitus.
Topics: 5'-Nucleotidase; Adenosine; Adult; Antigens, CD; Apoptosis; Apyrase; Body Mass Index; CD8-Positive T-Lymphocytes; Diabetes Mellitus, Type 2; Gene Expression Regulation; GPI-Linked Proteins; Humans; Inflammation; Lymphocyte Subsets; Lymphocytes; Obesity; Phenethylamines; Receptor, Adenosine A2A; Triazines; Triazoles | 2015 |
Alkaline phosphatase protects against renal inflammation through dephosphorylation of lipopolysaccharide and adenosine triphosphate.
Topics: Acute Kidney Injury; Adrenergic alpha-2 Receptor Antagonists; Alkaline Phosphatase; Animals; Cells, Cultured; Cytokines; Epithelial Cells; Fluoresceins; Gene Expression Regulation; Humans; Inflammation; Kidney; Lipopolysaccharides; Male; Oligosaccharides; Protective Agents; Purines; Rats, Sprague-Dawley; Recombinant Proteins; Triazines; Triazoles | 2015 |
Caffeine promotes anti-tumor immune response during tumor initiation: Involvement of the adenosine A2A receptor.
Topics: Adenosine A2 Receptor Antagonists; Animals; Caffeine; Cell Line, Tumor; Cyclopentanes; Fibrosarcoma; Mice; Mice, Knockout; Neoplasms, Experimental; Receptor, Adenosine A2A; Triazines; Triazoles | 2015 |
Evaluation of the expression and function of the P2X7 receptor and ART1 in human regulatory T-cell subsets.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine Triphosphate; Adolescent; ADP Ribose Transferases; Adult; Antigens, CD; Apyrase; Cell Death; Cell Proliferation; Female; Gene Expression Regulation; GPI-Linked Proteins; Humans; Immunophenotyping; L-Selectin; Male; NAD; Phenethylamines; Primary Cell Culture; Receptors, Adenosine A2; Receptors, Purinergic P2X7; Signal Transduction; T-Lymphocyte Subsets; Triazines; Triazoles | 2016 |
Adenosine A2A receptor plays an important role in radiation-induced dermal injury.
Topics: Adenosine A2 Receptor Antagonists; Animals; Collagen; Keratinocytes; Mice; Mice, Inbred C57BL; Myofibroblasts; Radiodermatitis; Receptor, Adenosine A2A; Triazines; Triazoles | 2016 |
Mass spectrometry-based ligand binding assays on adenosine A1 and A2A receptors.
Topics: Animals; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Deuterium; Humans; Isotope Labeling; Ligands; Mass Spectrometry; Radioligand Assay; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptors, G-Protein-Coupled; Reference Standards; Reproducibility of Results; Triazines; Triazoles; Xanthines | 2015 |
PI3K/Akt signaling pathway is involved in the neurotrophic effect of senegenin.
Topics: Animals; Cell Survival; Chromones; Drugs, Chinese Herbal; Humans; Morpholines; Neurites; Neurodegenerative Diseases; Neurons; Phosphatidylinositol 3-Kinases; Polygala; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Triazines; Triazoles | 2016 |
7TM X-ray structures for class C GPCRs as new drug-discovery tools. 1. mGluR5.
Topics: Benzamides; Binding Sites; Crystallography, X-Ray; Drug Discovery; Indoles; Ligands; Models, Molecular; Molecular Docking Simulation; Molecular Structure; Protein Domains; Pyrazoles; Pyridines; Pyrimidines; Receptor, Metabotropic Glutamate 5; Thiazoles; Triazines; Triazoles | 2016 |
Ligand-Independent Adenosine A2B Receptor Constitutive Activity as a Promoter of Prostate Cancer Cell Proliferation.
Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine Deaminase; Animals; Cell Line, Tumor; Cell Proliferation; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Drug Design; Humans; Inositol Phosphates; Ligands; Male; MAP Kinase Signaling System; Prostatic Neoplasms; Receptor, Adenosine A2B; Signal Transduction; Sulfonamides; Triazines; Triazoles; Xanthines | 2016 |
Molecular Basis of Ligand Dissociation from the Adenosine A2A Receptor.
Topics: Adenosine A2 Receptor Antagonists; Amino Acid Substitution; Binding Sites; Cell Membrane; Databases, Protein; HEK293 Cells; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Kinetics; Ligands; Models, Molecular; Molecular Conformation; Molecular Dynamics Simulation; Mutation; Radioligand Assay; Receptor, Adenosine A2A; Recombinant Proteins; Solubility; Triazines; Triazoles | 2016 |
The Effect of A2A Receptor Antagonist on Microglial Activation in Experimental Glaucoma.
Topics: Adenosine A2 Receptor Antagonists; Animals; Blotting, Western; Cell Count; Cells, Cultured; Chronic Disease; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Glaucoma; Immunohistochemistry; Intravitreal Injections; Male; Microglia; Ocular Hypertension; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Retinal Ganglion Cells; RNA; Triazines; Triazoles | 2016 |
Controlling the Dissociation of Ligands from the Adenosine A2A Receptor through Modulation of Salt Bridge Strength.
Topics: Cells, Cultured; Crystallography, X-Ray; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Ligands; Models, Molecular; Molecular Structure; Protein Engineering; Receptor, Adenosine A2A; Structure-Activity Relationship; Triazines; Triazoles | 2016 |
Early synaptic deficits in the APP/PS1 mouse model of Alzheimer's disease involve neuronal adenosine A2A receptors.
Topics: Adenosine A2 Receptor Antagonists; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; CA3 Region, Hippocampal; Dendritic Spines; Disease Models, Animal; Gene Expression Regulation; Humans; Long-Term Potentiation; Memory, Episodic; Mice; Mice, Transgenic; Neuroprotective Agents; Presenilin-1; Pyrimidines; Receptor, Adenosine A2A; Receptors, N-Methyl-D-Aspartate; RNA, Small Interfering; Signal Transduction; Synapses; Triazines; Triazoles | 2016 |
Oral administration of Japanese sake yeast (Saccharomyces cerevisiae sake) promotes non-rapid eye movement sleep in mice via adenosine A
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Administration, Oral; Alcoholic Beverages; Animals; Electroencephalography; Electromyography; Eye Movements; Japan; Locomotion; Male; Mice; Mice, Inbred C57BL; Receptor, Adenosine A2A; Saccharomyces cerevisiae; Sleep; Sleep, REM; Theophylline; Time Factors; Triazines; Triazoles | 2016 |
An Fc-Small Molecule Conjugate for Targeted Inhibition of the Adenosine 2A Receptor.
Topics: Adenosine A2 Receptor Antagonists; Animals; Female; Humans; Immunoglobulin Fab Fragments; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Molecular; Molecular Structure; Receptor, Adenosine A2A; Respiratory Tract Infections; Triazines; Triazoles; Vaccinia virus | 2016 |
Equilibrative nucleoside transporter ENT1 as a biomarker of Huntington disease.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Biomarkers; Corpus Striatum; Disease Models, Animal; Gene Expression Regulation; Humans; Huntingtin Protein; Huntington Disease; Locomotion; Nucleoside Transport Proteins; Prefrontal Cortex; Psychomotor Disorders; Purines; Rats; Rats, Transgenic; Receptor, Adenosine A2A; Triazines; Triazoles; Trinucleotide Repeat Expansion; Tritium | 2016 |
Inosine attenuates spontaneous activity in the rat neurogenic bladder through an A
Topics: Adenosine A2 Receptor Antagonists; Animals; Disease Models, Animal; Humans; Inosine; Potassium Channels; Rats; Receptor, Adenosine A2A; Spinal Cord Injuries; Sulfonamides; Triazines; Triazoles; Urinary Bladder, Neurogenic; Urinary Bladder, Overactive; Xanthines | 2017 |
Adenosine A
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adult; Aged; Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Disease Models, Animal; Female; Glycogen Synthase Kinase 3 beta; Glycogen Synthase Kinases; Hippocampus; Humans; Indoles; Isoquinolines; Male; Maleimides; Mice; Mice, Knockout; Middle Aged; Neurons; Phenethylamines; Phosphorylation; Protein Kinase Inhibitors; Receptor, Adenosine A2A; Signal Transduction; Sulfonamides; tau Proteins; Triazines; Triazoles | 2017 |
Preemptive Caffeine Administration Blocks the Increase in Postoperative Pain Caused by Previous Sleep Loss in the Rat: A Potential Role for Preoptic Adenosine A2A Receptors in Sleep-Pain Interactions.
Topics: Adenosine A2 Receptor Antagonists; Animals; Caffeine; Female; Hyperalgesia; Male; Pain, Postoperative; Preoptic Area; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Sex Characteristics; Sleep; Sleep Deprivation; Triazines; Triazoles | 2017 |
Impaired autophagic flux is associated with the severity of trauma and the role of A
Topics: Adenosine A2 Receptor Antagonists; Animals; Autophagosomes; Autophagy; Autophagy-Related Protein 12; Autophagy-Related Protein 5; Beclin-1; Brain Injuries, Traumatic; Cerebral Cortex; Chloroquine; Disease Models, Animal; Female; Gene Expression Regulation; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Microtubule-Associated Proteins; Neurons; Neuroprotective Agents; Receptor, Adenosine A2A; Sequestosome-1 Protein; Signal Transduction; Trauma Severity Indices; Triazines; Triazoles | 2018 |
Mechanistic insights into allosteric regulation of the A
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Allosteric Regulation; Amino Acid Sequence; Animals; Binding Sites; Calcium; Cations, Divalent; Crystallography, X-Ray; Gene Expression; Humans; Kinetics; Magnesium; Models, Molecular; Molecular Dynamics Simulation; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Receptor, Adenosine A2A; Recombinant Proteins; Sf9 Cells; Spodoptera; Thermodynamics; Triazines; Triazoles | 2018 |
Effects of caffeine and phosphodiesterase inhibitors on activation of neonatal T lymphocytes.
Topics: Adenosine A2 Receptor Antagonists; Adult; Aging; Caffeine; Calcium Signaling; Cells, Cultured; Cyclic AMP; Cytokines; Female; Humans; Infant, Newborn; Leukocytes, Mononuclear; Lymphocyte Activation; Male; Milrinone; Phosphodiesterase Inhibitors; Reactive Oxygen Species; Sildenafil Citrate; T-Lymphocytes; Triazines; Triazoles | 2018 |
Cervical cancer cells produce TGF-β1 through the CD73-adenosine pathway and maintain CD73 expression through the autocrine activity of TGF-β1.
Topics: 5'-Nucleotidase; Acetamides; Adenosine; Adenosine A2 Receptor Antagonists; Autocrine Communication; Cell Line, Tumor; Female; GPI-Linked Proteins; HeLa Cells; Humans; Immunosuppression Therapy; Purines; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Transforming Growth Factor beta1; Triazines; Triazoles; Tumor Microenvironment; Uterine Cervical Neoplasms | 2019 |
Ischemia postconditioning protects dermal microvascular endothelial cells of rabbit epigastric skin flaps against apoptosis via adenosine A2a receptors.
Topics: Abdomen; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Apoptosis; Dermis; Endothelial Cells; Ischemic Postconditioning; Models, Animal; Phenethylamines; Rabbits; Surgical Flaps; Triazines; Triazoles | 2019 |
Impact of combination immunochemotherapies on progression of 4NQO-induced murine oral squamous cell carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Combined Chemotherapy Protocols; Cancer Vaccines; Cisplatin; Combined Modality Therapy; Female; Immunotherapy; Mice; Mice, Inbred C57BL; Mouth Neoplasms; Neoplasms, Experimental; Squamous Cell Carcinoma of Head and Neck; Treatment Outcome; Triazines; Triazoles; Vaccines, Subunit | 2019 |
Number of Circulating CD 73-Expressing Lymphocytes Correlates With Survival After Cardiac Arrest.
Topics: 5'-Nucleotidase; Adenosine A2 Receptor Antagonists; Adenosine Diphosphate; Adenosine Monophosphate; Aged; Antigens, CD; Apyrase; Cardiopulmonary Resuscitation; Case-Control Studies; Enzyme Inhibitors; Female; Heart Arrest; Humans; In Vitro Techniques; Leukocyte Count; Lymphocytes; Male; Middle Aged; Myeloid Cells; Prognosis; Reactive Oxygen Species; Triazines; Triazoles; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2019 |
Contribution of adenosine and ATP to the carotid body chemosensory activity in ageing.
Topics: Adenosine; Adenosine Triphosphate; Aging; Animals; Antinematodal Agents; Carotid Body; Chemoreceptor Cells; Female; Gene Expression Regulation; Male; Rats; Rats, Wistar; Suramin; Triazines; Triazoles | 2019 |
Ligand-Dependent Sodium Ion Dynamics within the A
Topics: Binding Sites; Humans; Ions; Ligands; Molecular Dynamics Simulation; Receptor, Adenosine A2A; Sodium; Triazines; Triazoles | 2019 |
Ligand-induced conformational changes in a SMALP-encapsulated GPCR.
Topics: Hydrophobic and Hydrophilic Interactions; Ligands; Lipids; Maleates; Pichia; Protein Conformation; Receptor, Adenosine A2A; Spectrometry, Fluorescence; Styrene; Triazines; Triazoles; Tryptophan | 2020 |
In Vitro, In Silico, and In Vivo Assessments of Pharmacokinetic Properties of ZM241385.
Topics: Adenosine A2 Receptor Antagonists; Animals; Computer Simulation; Male; Parkinson Disease; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Triazines; Triazoles | 2020 |
Adenosine Receptors as Neuroinflammation Modulators: Role of A
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Cells, Cultured; Inflammation; Male; Neuroglia; Neurons; Rats, Wistar; Receptors, Purinergic P1; Triazines; Triazoles | 2020 |
Suppression of adenosine A
Topics: Adenosine A2 Receptor Antagonists; Animals; Antineoplastic Agents, Alkylating; Cyclophosphamide; Cystitis; Female; Hyperalgesia; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Triazines; Triazoles; TRPV Cation Channels; Urinary Bladder; Urinary Bladder, Overactive | 2021 |
Ligand-directed covalent labelling of a GPCR with a fluorescent tag in live cells.
Topics: Affinity Labels; Drug Design; Fluorescent Dyes; HEK293 Cells; Humans; Ligands; Receptor, Adenosine A2A; Receptors, G-Protein-Coupled; Triazines; Triazoles | 2020 |