triazoles has been researched along with thiophenes in 113 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 8 (7.08) | 18.7374 |
1990's | 8 (7.08) | 18.2507 |
2000's | 16 (14.16) | 29.6817 |
2010's | 75 (66.37) | 24.3611 |
2020's | 6 (5.31) | 2.80 |
Authors | Studies |
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Kilbey, BJ; Zetterberg, LG | 1 |
Aboul Wafa, OM; Berto, FA | 1 |
Atienza, J; Claramunt, RM; Elguero, J; Escario, JA; Gómez Barrio, A; Mester, B | 1 |
Crowley, H; Flynn, T; Maresca, C; Mason, C; O'Donnell, M; Walser, A; Yaremko, B | 1 |
Crowley, H; Flynn, T; Maresca, C; Mason, C; O'Donnell, M; Walser, A | 1 |
Baumann, K; Binder, D; Noe, CR; Wildburger, JM | 1 |
Maruyama, Y; Mikashima, H; Tahara, T; Terasawa, M | 1 |
Glukhov, NV; Kulikova, LK | 1 |
Berk, S; Gisser, H | 1 |
Theus, PM; Tiedt, H; Weuffen, W | 1 |
Dunoff, RY; Graboyes, H; Jaffe, G; Karash, CB; Pachter, IJ; Snader, K; Weinstock, J | 1 |
Modica, M; Russo, F; Santagati, A; Santagati, M; Spampinato, S | 1 |
Kuwano, M; Ono, M | 1 |
Algueró, M; Bartroli, J; Boncompte, E; Conte, L; Forn, J; García-Rafanell, J; Merlos, M; Ramis, J; Turmo, E; Vericat, ML | 1 |
Bu, W; Li, XM; Qin, LX; Tang, ZY; Xia, JL | 1 |
Dalvie, DK; Kalgutkar, AS; Khojasteh-Bakht, SC; O'Donnell, JP; Obach, RS | 1 |
Henry, AA; Matsuda, S; Romesberg, FE; Schultz, PG | 1 |
KANNER, LC; KOZLOFF, LM | 1 |
Dobosz, M; Kosikowska, U; Malm, A; Pitucha, M; Wujec, M | 1 |
Almási, J; Rihmer, Z | 1 |
Berrino, L; de Novellis, V; Maione, S; Marabese, I; Mariani, L; Oliva, P; Palazzo, E; Rossi, F; Scafuro, M; Siniscalco, D | 1 |
Aoudjit, L; Potapov, A; Takano, T | 1 |
Ammar, H; Malani, AK | 1 |
Kamio, K; Kawasaki, S; Kobayashi, T; Liu, X; Mao, LJ; Rennard, SI; Shen, L; Sugiura, H; Togo, S; Wang, XQ | 1 |
Chen, XB; Cherukuri, DP; Goulet, AC; Han, Y; Heimark, RL; Meuillet, E; Nelson, MA; Regan, JW; Young, RN | 1 |
Fisher, PW; Hofmann, GA; Janson, CA; Johnson, RK; Kirkpatrick, RB; Ma, C; Marino, JP; Mattern, M; Meek, TD; Ryan, MD; Schulz, C; Smith, WW; Tew, DG; Thompson, SK; Tomazek, TA; Veber, DF; Xiong, WC; Yamamoto, Y; Yamashita, K; Yang, G | 1 |
Bis, SJ; Bruce, TJ; Cudworth, DP; Dintenfass, LP; Dripps, JE; Gifford, JM; Guenthenspberger, KA; Hamilton, CT; Hegde, VB; Johnson, PL; Karr, LL; Kempe, MK; McCormick, DC; Pechacek, JT; Schoonover, JR; Tisdell, FE; Yap, MC | 1 |
Cicha, MZ; Hökfelt, T; Kopp, UC; Mulder, J; Smith, LA | 1 |
Da Settimo, F; Martini, C; Montali, M; Taliani, S; Trincavelli, ML | 1 |
Al-Bayati, RH; Aouad, M; Rezki, N; Sharba, AH | 1 |
Hussar, DA | 2 |
Barnett, JM; Clark, ML; Penn, JS; Yanni, SE | 1 |
Cuthbert, AW | 1 |
Balan, A; Ekiz, F; Timur, S; Toppare, L; Yuksel, M | 1 |
Berthelette, C; Chateauneuf, A; Li, L; Ouellet, M; Sturino, CF; Wang, Z | 1 |
Dighe, R; Kanase, V; Shiradkar, M; Thomas, J | 1 |
Arun, B; Brown, PH; Castiglione, M; Cuzick, J; DeCensi, A; Dunn, B; Forbes, JF; Glaus, A; Howell, A; Vogel, V; von Minckwitz, G; Zwierzina, H | 1 |
Al-Majid, AM; Alamary, AS; Mabkhot, YN | 1 |
Hinge, VK; Mondal, M; Pathak, RK; Rao, CP | 1 |
Beigelman, L; Blatt, L; Cai, H; Deval, J; Fan, B; Kao, CC; Ranjith-Kumar, CT; Smith, DB; Soulard, C; Yi, G | 1 |
Brooks, W; Daniel, KG; Ge, Y; Guida, WC; Jain, S; Kazi, A; Lawrence, HR; Luo, Y; Marsilio, F; Sebti, SM | 1 |
Fuskevåg, OM; Gogvadze, V; Johnsen, JI; Kock, A; Kogner, P; Kruspig, B; Rasmuson, A; Simón-Santamaría, J; Sveinbjörnsson, B | 1 |
Chen, H; Ma, Z; Wang, N; Yin, Y; Yu, F; Yun, Y | 1 |
Anjana Devi, T; Jain, N; Kalivendi, SV; Kantevari, S; Murthy, R; Patpi, SR; Pulipati, L; Sridhar, B; Sriram, D; Yogeeswari, P | 1 |
Capuano, G; Nicolle, LE; Usiskin, K; Ways, K | 1 |
Kadokura, T; Keirns, J; Krauwinkel, WJ; Smulders, RA; van Dijk, J; Veltkamp, SA; Zhang, W | 1 |
Nyirjesy, P; Usiskin, K; Ways, K; Zhao, Y | 1 |
Burke, M; Cogan, D; Gao, DA; Haverty, K; Heim-Riether, A; Hickey, ER; Moss, N; Nagaraja, R; Netherton, M; O'Shea, K; Ramsden, P; Schwartz, R; Shih, DT; Ward, Y; Xiong, Z; Young, E; Zhang, Q | 1 |
Barrett, DG; Beavers, LS; Briere, DA; Coskun, T; Dubois, SL; Efanov, AM; Franciskovich, JB; Michael, MD; O'Farrell, LS; Syed, SK | 1 |
Appleby, TC; Bidgood, AM; Byun, D; Canales, E; Clarke, MO; Doerffler, E; Eng, S; Fenaux, M; Hashash, A; Krawczyk, SH; Lazerwith, SE; Leavitt, SA; Lee, YJ; Lew, W; Liu, Q; Mabery, EM; Matles, M; Mertzman, M; Morganelli, P; Murray, BP; Mwangi, J; Tian, Y; Watkins, WJ; Xu, L; Ye, H; Zhang, J | 1 |
Ashour, HM; El-Ashmawy, IM; Rizk, OH; Shaaban, OG | 1 |
Abbate, I; Almerico, AM; Dattolo, G; Lauria, A; Martorana, A; Patella, C | 1 |
Li, X; Li, Y; Tan, L; Tang, T; Wang, J; Wu, Y; Xu, Z; Yang, P; Zhao, L; Zhao, Z | 1 |
Canovatchel, W; Fu, M; Gross, JL; Guarisco, M; Kawaguchi, M; Meininger, G; Rosenstock, J; Schernthaner, G; Yee, J | 1 |
Johnson, MS | 1 |
Hwang, DH; Kang, H; Kang, IN; Kim, B; Kim, BJ; Kim, JH; Kim, JS; Shin, N; Shin, WS; Song, CE; Wood, S | 1 |
Gu, Y; Han, Y; Ma, G; Shi, H; Tang, C; Wang, Q; Yan, G | 1 |
Canovatchel, W; Davidson, J; Januszewicz, A; Lavalle-González, FJ; Meininger, G; Qiu, R; Tong, C | 1 |
Alba, M; Canovatchel, W; Cefalu, WT; Edwards, R; Jodar, E; Kim, KA; Meininger, G; Stenlöf, K; Tong, C | 1 |
Cantonwine, EG; Johnson, RC | 1 |
Baxi, SM; Estrella, H; Li, C; Liu, KK; Mehta, PP; Smeal, T; Walls, M; Yin, MJ; Zhu, J; Zientek, M; Zong, Q | 1 |
Andersson, G; Hu, L; Jacobson, A; Lind, T; Melhus, H; Pejler, G; Sundqvist, A | 1 |
Schnell, O | 1 |
Bailey, RA; Blonde, L; Damaraju, CV; Martin, SC; Meininger, GE; Rupnow, MF | 1 |
Forst, T; Goldenberg, R; Guthrie, R; Meininger, G; Stein, P; Vijapurkar, U; Yee, J | 1 |
Ferrannini, E; Mari, A; Polidori, D | 1 |
Al-Abdullah, ES; Al-Tamimi, AM; Cırak, C; El-Emam, AA; Sert, Y; Ucun, F | 1 |
Guthrie, R; Slee, A; Traina, S | 1 |
Geolchanyan, AV; Musumeci, D; Petrosyan, SG; Roviello, GN; Roviello, V; Saghyan, AS; Simonyan, HM | 1 |
Birinci, E; Burnaz, NA; Çelik, F; Küçük, M; Sancak, K; Soylu, S; Ünver, Y | 1 |
Baltaş, N; Bekircan, O; Kahveci, B; Menteşe, E; Yılmaz, F | 1 |
Lubenov, LA; Mavrova, ATs; Tsenov, JA; Wesselinova, D | 1 |
Douglas, MW; Eltahla, AA; Tay, E; White, PA | 1 |
Dzitko, K; Paneth, A; Paneth, P; Pawełczyk, J; Plech, T; Węglińska, L | 1 |
Bridges, CR; Pollit, AA; Seferos, DS | 1 |
Jin, YH; Jin, Z; Kim, S; Lee, G; Park, CS; Park, YS | 1 |
Gallego, D; Jimenez, M; Mañé, N; Martin, MT; Martinez-Cutillas, M | 1 |
Cai, Y; Libby, P; Rocha, VZ; Shimizu, K; Sukhova, GK; Tang, EH; Vanhoutte, PM; Wong, CK; Xu, A; Xuan, G | 1 |
An, Y; Li, N; Song, Y; Tang, H; Wang, Y; Zhang, L | 1 |
Bailey, RA; Blonde, L; Meininger, GE; Rupnow, MF; Vijapurkar, U | 1 |
Bonewald, L; Brotto, M; Igwe, O; Mo, C; Vallejo, J; Wetmore, L; Zhao, R | 1 |
Bailey, RA; Blonde, L; Meininger, G; Rupnow, MF; Vijapurkar, U | 1 |
Allison, S; Hoang, KG; Murray, M; Petrovic, N | 1 |
Chen, YR; Li, YH; Liu, Y; Pan, ES; You, WW; Zhang, B; Zhao, PL | 1 |
Copp, SW; Kaufman, MP; Kim, JS; Stone, AJ | 1 |
Choi, H; Jo, H; Ko, HM; Ko, J; Koh, K; Lee, JK; Paek, S | 1 |
Bonomo, RA; Caselli, E; Krishnan, NP; Nguyen, NQ; Prati, F; Rojas, LJ; Romagnoli, C; van den Akker, F | 1 |
Abdelaziz, MA; El-Sayed, NN; Mohareb, RM; Wardakhan, WW | 1 |
Abdel-Ghany, R; Barakat, W; El-Ahwany, E; Gamal, R; Hamad, RS; Mahmoud, O; Nagy, F; Rabia, I; Saber, S | 1 |
Deredge, D; Johnson, KA; Li, J; Wintrode, PL | 1 |
Chow, KBS; Tse, KH; Wise, H | 1 |
Kantevari, S; Pulipati, L; Sriram, D; Yogeeswari, P | 1 |
Baillie, TA; Cyrus Khojasteh, S; Dalvie, D; Rietjens, IM | 1 |
Bari, F; Farkas, E; Hertelendy, P; Ivánkovits-Kiss, O; Menyhárt, Á; Puskás, T; Tóth, R; Varga, DP; Zölei-Szénási, D | 1 |
Bastos, IM; de Almeida, H; Grellier, P; Leroux, V; Maigret, B; Motta, FN; Santana, JM | 1 |
Kaieda, A; Kanzaki, N; Kori, M; Kuno, H; Mototani, H; Naito, T; Nara, H; Oki, H; Santou, T; Sato, K; Terauchi, J; Uchikawa, O; Yamamoto, Y | 1 |
Garcia, MD; Guddat, LW; Lonhienne, TG; Nouwens, A | 1 |
Han, G; Li, W; Li, X; Yang, B | 1 |
Ambudkar, SV; Chou, AW; Hsiao, SH; Huang, YH; Hung, TH; Li, YQ; Murakami, M; Wu, CP | 1 |
Chen, L; Li, D; Wu, X; Zhong, J | 1 |
Carlock, C; Elzey, BD; Kong, Y; Li, J; Liu, X; Liu, Z; Luo, Q; Mao, F; Wang, R | 1 |
Bogolyubsky, AV; Brovarets, VS; Doroshchuk, RO; Grishchenko, AV; Khomenko, DN; Konovets, AI; Moroz, YS; Pipko, SE; Savych, O; Vybornyi, M; Zhemera, AV | 1 |
Amelung, W; An, NT; Braun, G; Braun, M; Kruse, J; Renaud, FG; Sebesvari, Z | 1 |
Del Mar Montiel-Rozas, M; Diéz-Rojo, MÁ; Pascual, JA; Ros, M; Santísima-Trinidad, ABL | 1 |
Alagusundaram, P; Jaabil, G; Murugavel, S; Ravikumar, C | 1 |
Avdonin, PP; Avdonin, PV; Goncharov, NV; Mironova, GY; Nadeev, AD; Zharkikh, IL | 1 |
Abou El-Alamin, MM; Aboul-Enein, HY; Atia, MA; Sultan, MA | 1 |
Costello, DA; Jones, AC; Pinki, F; Stewart, GS | 1 |
Bergthaler, A; Bigenzahn, JW; César-Razquin, A; Kartnig, F; Kornauth, C; Lercher, A; Pemovska, T; Srndic, I; Staber, PB; Superti-Furga, G; Valent, P | 1 |
Jakubowski, M; Jarzęcki, AA; Kaszuba, A; Sitkowski, J; Wojtczak, A; Łakomska, I | 1 |
Bogucka-Kocka, A; Helmin-Basa, A; Kołodziej, P; Paprocka, R; Wiese-Szadkowska, M | 1 |
Kamra, N; Kumar, D; Rani, S; Sangwan, PL; Singh, A; Singh, SK; Singh, V; Thakral, S | 1 |
8 review(s) available for triazoles and thiophenes
Article | Year |
---|---|
[Development of anti tumor agents targeting angiogenesis].
Topics: Antineoplastic Agents; Clinical Trials as Topic; Cyclohexanes; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Hydroxamic Acids; Interferon-alpha; Interleukin-12; Neoplasms; Neovascularization, Pathologic; O-(Chloroacetylcarbamoyl)fumagillol; Phenylalanine; Platelet Factor 4; Polysaccharides, Bacterial; Sesquiterpenes; Thalidomide; Thiophenes; Triazines; Triazoles; Tumor Cells, Cultured | 1997 |
Biotransformation reactions of five-membered aromatic heterocyclic rings.
Topics: Animals; Cytochrome P-450 Enzyme System; Furans; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Indoles; Isoxazoles; Models, Chemical; Molecular Structure; Oxadiazoles; Oxazoles; Pyrazoles; Pyrroles; Tetrazoles; Thiadiazoles; Thiazoles; Thiophenes; Triazoles; Xenobiotics | 2002 |
[Review of antidepressants from the TCAs to the third generation drugs].
Topics: Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Bupropion; Cyclohexanols; Cyclopropanes; Depressive Disorder, Major; Drug Combinations; Duloxetine Hydrochloride; Humans; Mianserin; Milnacipran; Mirtazapine; Monoamine Oxidase Inhibitors; Morpholines; Piperazines; Pyrimidines; Reboxetine; Selective Serotonin Reuptake Inhibitors; Thiophenes; Trazodone; Triazoles; Venlafaxine Hydrochloride | 2004 |
GABA A/Bz receptor subtypes as targets for selective drugs.
Topics: Benzodiazepines; Carbolines; Flavones; Indoles; Pyrazoles; Pyridazines; Pyridones; Receptors, GABA-A; Thiophenes; Triazoles | 2007 |
Preventive therapy for breast cancer: a consensus statement.
Topics: Anastrozole; Androstadienes; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Consensus Development Conferences as Topic; Diphosphonates; Estrogen Receptor Modulators; Expert Testimony; Female; Fenretinide; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Metformin; Nitriles; Norpregnenes; Piperidines; Premenopause; Pyrrolidines; Raloxifene Hydrochloride; Retinoids; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes; Triazoles | 2011 |
[Oral add-on therapy to metformin in type 2 diabetes mellitus: a direct comparison between canagliflozin and sitagliptin].
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Blood Glucose; Blood Pressure; Body Weight; Canagliflozin; Clinical Trials, Phase III as Topic; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endpoint Determination; Female; Glucosides; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Pyrazines; Randomized Controlled Trials as Topic; Sitagliptin Phosphate; Thiophenes; Triazoles; Young Adult | 2014 |
Diabetes-Related Composite Quality End Point Attainment: Canagliflozin Versus Sitagliptin Based on a Pooled Analysis of 2 Clinical Trials.
Topics: Blood Pressure; Body Mass Index; Canagliflozin; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Glucosides; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Middle Aged; Pyrazines; Randomized Controlled Trials as Topic; Sitagliptin Phosphate; Thiophenes; Triazoles | 2015 |
Biotransformation and bioactivation reactions - 2015 literature highlights.
Topics: Acetaminophen; Allylbenzene Derivatives; Aniline Compounds; Animals; Anisoles; Benzbromarone; Biotransformation; Humans; Imidazoles; Niacinamide; Nitroimidazoles; Nitrosamines; Oxazoles; Oxazolidinones; Peroxides; Pyrazines; Pyrazoles; Pyridazines; Pyridines; Pyridones; Pyrimidinones; Thiophenes; Triazoles | 2016 |
12 trial(s) available for triazoles and thiophenes
Article | Year |
---|---|
Effect of canagliflozin, a sodium glucose co-transporter 2 (SGLT2) inhibitor, on bacteriuria and urinary tract infection in subjects with type 2 diabetes enrolled in a 12-week, phase 2 study.
Topics: Bacteriuria; Blood Glucose; Canagliflozin; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glucosides; Glycosuria; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Pyrazines; Sitagliptin Phosphate; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Thiophenes; Triazoles; Urinary Tract Infections | 2012 |
No pharmacokinetic interaction between ipragliflozin and sitagliptin, pioglitazone, or glimepiride in healthy subjects.
Topics: Adolescent; Adult; Area Under Curve; Body Mass Index; Cross-Over Studies; Diabetes Mellitus, Type 2; Drug Interactions; Drug Therapy, Combination; Female; Glucosides; Humans; Hypoglycemic Agents; Male; Middle Aged; Pioglitazone; Pyrazines; Sitagliptin Phosphate; Sulfonylurea Compounds; Thiazolidinediones; Thiophenes; Triazoles | 2012 |
Evaluation of vulvovaginal symptoms and Candida colonization in women with type 2 diabetes mellitus treated with canagliflozin, a sodium glucose co-transporter 2 inhibitor.
Topics: Antifungal Agents; Blood Glucose; Canagliflozin; Candida; Candidiasis, Vulvovaginal; Diabetes Mellitus, Type 2; Female; Glucosides; Humans; Hypoglycemic Agents; Middle Aged; Pyrazines; Sitagliptin Phosphate; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Thiophenes; Triazoles; Vagina | 2012 |
Preclinical characterization of GS-9669, a thumb site II inhibitor of the hepatitis C virus NS5B polymerase.
Topics: Animals; Antiviral Agents; Cell Line, Tumor; Dogs; Drug Resistance, Viral; Furans; Hepacivirus; Humans; Interferon-alpha; Male; Mutation; Polymorphism, Single Nucleotide; Pyrones; Rats; Rats, Sprague-Dawley; Ribavirin; RNA-Dependent RNA Polymerase; Thiophenes; Triazoles; Viral Nonstructural Proteins | 2013 |
Canagliflozin compared with sitagliptin for patients with type 2 diabetes who do not have adequate glycemic control with metformin plus sulfonylurea: a 52-week randomized trial.
Topics: Aged; Blood Glucose; Canagliflozin; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glucosides; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Pyrazines; Sitagliptin Phosphate; Sulfonylurea Compounds; Thiophenes; Treatment Outcome; Triazoles | 2013 |
Efficacy and safety of canagliflozin compared with placebo and sitagliptin in patients with type 2 diabetes on background metformin monotherapy: a randomised trial.
Topics: Adolescent; Aged; Aged, 80 and over; Blood Glucose; Blood Pressure; Body Weight; Canagliflozin; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Fasting; Female; Glucosides; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Lipids; Male; Metformin; Middle Aged; Pyrazines; Sitagliptin Phosphate; Thiophenes; Treatment Outcome; Triazoles | 2013 |
Long-term efficacy and safety of canagliflozin monotherapy in patients with type 2 diabetes inadequately controlled with diet and exercise: findings from the 52-week CANTATA-M study.
Topics: Blood Glucose; Blood Pressure; Body Weight; Canagliflozin; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Diet; Double-Blind Method; Exercise; Female; Glucosides; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Male; Middle Aged; Placebos; Pyrazines; Sitagliptin Phosphate; Sodium-Glucose Transporter 2 Inhibitors; Thiophenes; Treatment Outcome; Triazoles; Triglycerides; Weight Loss | 2014 |
Attainment of diabetes-related quality measures with canagliflozin versus sitagliptin.
Topics: Aged; Blood Pressure; Body Mass Index; Canagliflozin; Cholesterol, LDL; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Glucosides; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Pyrazines; Quality Indicators, Health Care; Racial Groups; Sitagliptin Phosphate; Sodium-Glucose Transporter 2 Inhibitors; Thiophenes; Triazoles | 2014 |
Efficacy and safety of canagliflozin over 52 weeks in patients with type 2 diabetes on background metformin and pioglitazone.
Topics: Blood Glucose; Blood Pressure; Canagliflozin; Candidiasis; Diabetes Mellitus, Type 2; Diuretics, Osmotic; Double-Blind Method; Drug Therapy, Combination; Female; Genital Diseases, Female; Genital Diseases, Male; Glucosides; Humans; Hypoglycemic Agents; Lipids; Male; Metformin; Middle Aged; Pioglitazone; Pyrazines; Sitagliptin Phosphate; Thiazolidinediones; Thiophenes; Treatment Outcome; Triazoles; Weight Loss | 2014 |
Canagliflozin, a sodium glucose co-transporter 2 inhibitor, improves model-based indices of beta cell function in patients with type 2 diabetes.
Topics: Adult; Aged; Blood Glucose; C-Peptide; Canagliflozin; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glucosides; Humans; Insulin-Secreting Cells; Least-Squares Analysis; Male; Metformin; Middle Aged; Pyrazines; Sitagliptin Phosphate; Sodium-Glucose Transporter 2; Sulfonylurea Compounds; Thiophenes; Time Factors; Triazoles | 2014 |
The impact of weight loss on weight-related quality of life and health satisfaction: results from a trial comparing canagliflozin with sitagliptin in triple therapy among people with type 2 diabetes.
Topics: Adult; Age Factors; Aged; Body Weight; Canagliflozin; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Glucosides; Glycated Hemoglobin; Health Behavior; Humans; Hypoglycemic Agents; Male; Middle Aged; Personal Satisfaction; Pyrazines; Quality of Life; Self Efficacy; Sex Factors; Sexual Behavior; Sitagliptin Phosphate; Thiophenes; Triazoles; Weight Loss | 2014 |
Diabetes-related quality measure attainment: canagliflozin versus sitagliptin based on a pooled analysis of 2 clinical trials.
Topics: Blood Pressure; Body Mass Index; Body Weight; Canagliflozin; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glucosides; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Lipoproteins, LDL; Male; Middle Aged; Pyrazines; Sitagliptin Phosphate; Thiophenes; Treatment Outcome; Triazoles | 2014 |
93 other study(ies) available for triazoles and thiophenes
Article | Year |
---|---|
Mutagenicity assays on fluorescent whitening agents using microorganisms.
Topics: Biphenyl Compounds; Coloring Agents; Escherichia coli; Genes; Mutagens; Neurospora crassa; Quinolines; Saccharomyces cerevisiae; Salmonella typhimurium; Stilbenes; Thiophenes; Triazoles | 1975 |
Benzo[b]thiophenes, Part I: Synthesis and antimicrobial activity of benzo[b]thienyl-1,3,4-oxadiazole, -1,2,4-triazoline, and -thiazoline derivatives.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Candida albicans; Microbial Sensitivity Tests; Oxadiazoles; Thiazoles; Thiophenes; Triazoles | 1992 |
Research for new antichagasic drugs.
Topics: Animals; Azoles; Benzimidazoles; Chagas Disease; Imidazoles; Indazoles; Indoles; Mice; Nifurtimox; Nitro Compounds; Thiophenes; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 1991 |
Triazolobenzo- and triazolothienodiazepines as potent antagonists of platelet activating factor.
Topics: Animals; Azepines; Benzodiazepines; Blood Platelets; Bronchoconstriction; Chemical Phenomena; Chemistry; Dogs; Guinea Pigs; Male; Molecular Conformation; Molecular Structure; Platelet Activating Factor; Structure-Activity Relationship; Thiophenes; Triazoles | 1991 |
Thienotriazolodiazepines as platelet-activating factor antagonists. Steric limitations for the substituent in position 2.
Topics: Animals; Azepines; Guinea Pigs; Indicators and Reagents; Lung; Magnetic Resonance Spectroscopy; Molecular Structure; Platelet Activating Factor; Structure-Activity Relationship; Thiophenes; Triazoles | 1991 |
[Thiophene as a structural element in physiologically active substances. 15. Thiophene analogs of an anxiolytic acting 1,2,4-triazolo[4,3-b]pyridazine].
Topics: Animals; Anti-Anxiety Agents; Chemical Phenomena; Chemistry; Pyridazines; Thiophenes; Triazoles | 1985 |
PAF antagonistic activity of some thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepines.
Topics: Azepines; Humans; In Vitro Techniques; Platelet Activating Factor; Platelet Aggregation; Thiophenes; Triazoles | 1987 |
[Antibacterial activity of new derivatives of nitrofuran and nitrothiophen].
Topics: Anti-Bacterial Agents; Escherichia coli; Furazolidone; Nitro Compounds; Nitrofurans; Staphylococcus; Thiophenes; Triazoles | 1973 |
Radiation chemistry of nitrogen and sulfur heterocyclics.
Topics: Chromatography, Gas; Free Radicals; Heterocyclic Compounds; Imidazoles; Nitrogen; Pyrazines; Pyrazoles; Pyrimidines; Pyrroles; Radiochemistry; Sulfur; Tetrazoles; Thiazoles; Thiophenes; Triazines; Triazoles | 1973 |
[Studies on nitrothiophene and nitrofuran derivatives. 3. Conversion of 5-nitrothiophene-2- and 5-nitrofuran-2-iminocarbonic acid ethyl ester with semicarbazide and thiosemicarbazides and antimicrobial properties of compounds].
Topics: Amidines; Bacteria; Fungi; Helminths; Nitrofurans; Semicarbazides; Thiophenes; Thiosemicarbazones; Triazoles | 1968 |
Pteridines. 8. Some 2,4,7-triamino-6-heteroarylpteridines.
Topics: Chromatography, Paper; Furans; Hydrogen-Ion Concentration; Imidazoles; Oxazoles; Pteridines; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Spectrum Analysis; Thiazoles; Thiophenes; Triazoles; Ultraviolet Rays | 1968 |
Synthesis of aminothienopyrimidine and thienotriazolopyrimidine derivatives as potential anticonvulsant agents.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry, Physical; Male; Mice; Motor Activity; Pyrimidines; Rats; Seizures; Thiophenes; Triazoles | 1996 |
New azole antifungals. 2. Synthesis and antifungal activity of heterocyclecarboxamide derivatives of 3-amino-2-aryl-1-azolyl-2-butanol.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Candidiasis; Colony Count, Microbial; Fungi; Male; Mice; Molecular Conformation; Pyrimidinones; Rats; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Thiophenes; Triazoles | 1998 |
Effect of antiangiogenic agents on experimental animal models of hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents; Cell Division; Cyclohexanes; Liver Neoplasms, Experimental; Mice; Mice, Nude; Neoplasm Metastasis; Neovascularization, Pathologic; O-(Chloroacetylcarbamoyl)fumagillol; Phenylalanine; Sesquiterpenes; Suramin; Thiophenes; Triazoles | 1999 |
The effect of minor-groove hydrogen-bond acceptors and donors on the stability and replication of four unnatural base pairs.
Topics: Base Pairing; Benzofurans; Circular Dichroism; DNA; Hydrogen Bonding; Indoles; Kinetics; Nucleotides; Thiophenes; Triazoles | 2003 |
THE REACTION OF INDOLE AND T2 BACTERIOPHAGE.
Topics: Adsorption; Antimetabolites; Bacteriophage T4; Coliphages; Furans; Imidazoles; Indoles; Naphthalenes; Pharmacology; Purines; Quinolines; Research; Thiophenes; Triazoles | 1964 |
Synthesis and potential antimycotic activity of 4-substituted-3-(thiophene-2-yl-methyl)-Delta2-1,2,4-triazoline-5-thiones.
Topics: Antifungal Agents; Chemistry, Pharmaceutical; Hydrazines; Microbial Sensitivity Tests; Molecular Structure; Quantitative Structure-Activity Relationship; Semicarbazides; Technology, Pharmaceutical; Thiones; Thiophenes; Triazoles | 2004 |
Role of periaqueductal grey prostaglandin receptors in formalin-induced hyperalgesia.
Topics: Acetates; Acrylamides; Animals; Benzyl Compounds; Dimethyl Sulfoxide; Extracellular Fluid; Formaldehyde; gamma-Aminobutyric Acid; Glutamic Acid; Hyperalgesia; Injections, Intraventricular; Male; Mice; Microdialysis; Misoprostol; Naphthalenes; Pain Measurement; Periaqueductal Gray; Prostaglandin Antagonists; Receptors, Prostaglandin E; Thiophenes; Triazoles; Xanthones | 2006 |
Prostaglandin E2 promotes cell survival of glomerular epithelial cells via the EP4 receptor.
Topics: Animals; Apoptosis; Caspase 3; Caspases; Cell Survival; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclooxygenase 2; Enzyme Induction; Epithelial Cells; Gene Expression; Kidney Glomerulus; Nephrosis; Phosphoric Diester Hydrolases; Proteinuria; Puromycin Aminonucleoside; Rats; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; Thiophenes; Transfection; Triazoles | 2006 |
Medical management of depression.
Topics: Chemical and Drug Induced Liver Injury; Depressive Disorder; Duloxetine Hydrochloride; Humans; Liver Function Tests; Piperazines; Selective Serotonin Reuptake Inhibitors; Thiophenes; Triazoles | 2006 |
Prostaglandin E(2) protects human lung fibroblasts from cigarette smoke extract-induced apoptosis via EP(2) receptor activation.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alprostadil; Apoptosis; Carbazoles; Caspases; Cell Line; Cyclic AMP-Dependent Protein Kinases; Dideoxyadenosine; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Humans; Indoles; Lung; Nicotiana; Pyrroles; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; RNA, Small Interfering; Signal Transduction; Smoke; Thiophenes; Triazoles | 2007 |
The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclic AMP Response Element-Binding Protein; Dinoprostone; Early Growth Response Protein 1; Extracellular Signal-Regulated MAP Kinases; Humans; Promoter Regions, Genetic; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; Signal Transduction; Thiophenes; Transcription, Genetic; Triazoles | 2007 |
Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore.
Topics: Aminopeptidases; Angiogenesis Inhibitors; Animals; Aorta, Thoracic; Capillaries; Cell Proliferation; Crystallography, X-Ray; Endothelial Cells; Endothelium, Vascular; Furans; In Vitro Techniques; Male; Metalloendopeptidases; Models, Molecular; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiazoles; Thiophenes; Triazoles | 2007 |
Structure-activity relationship development of dihaloaryl triazole compounds as insecticides and acaricides. 1. Phenyl thiophen-2-yl triazoles.
Topics: Acari; Animals; Insecticides; Structure-Activity Relationship; Thiophenes; Triazoles | 2007 |
Renal sympathetic nerve activity modulates afferent renal nerve activity by PGE2-dependent activation of alpha1- and alpha2-adrenoceptors on renal sensory nerve fibers.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic Fibers; Animals; Calcitonin Gene-Related Peptide; Dinoprostone; Indomethacin; Kidney; Male; Neurons, Afferent; Neurons, Efferent; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; Substance P; Thiophenes; Triazoles | 2007 |
Synthesis of oxadiazoles, thiadiazoles and triazoles derived from benzo[b]thiophene.
Topics: Oxadiazoles; Thiadiazoles; Thiophenes; Triazoles | 2005 |
New drug update: 2007.
Topics: Aged; Amides; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antihypertensive Agents; Antiparkinson Agents; Antipsychotic Agents; Drug Approval; Fumarates; Humans; Hypoglycemic Agents; Isoxazoles; Macular Degeneration; Paliperidone Palmitate; Pyrazines; Pyrimidines; Ranibizumab; Sitagliptin Phosphate; Tetrahydronaphthalenes; Thiophenes; Triazoles; United States | 2008 |
The role of PGE2 receptor EP4 in pathologic ocular angiogenesis.
Topics: Animals; Animals, Newborn; Cell Proliferation; Choroid; Choroidal Neovascularization; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Humans; Laser Coagulation; Male; Mice; Neuroglia; Oxygen; Rats; Rats, Inbred BN; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; Retinal Neovascularization; Retinal Vessels; Thiophenes; Triazoles; Vascular Endothelial Growth Factor A | 2009 |
Lubiprostone targets prostanoid EP₄ receptors in ovine airways.
Topics: Adenylyl Cyclases; Alprostadil; Animals; Chloride Channels; CLC-2 Chloride Channels; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelial Cells; Humans; Lubiprostone; Molecular Targeted Therapy; Receptors, Prostaglandin E, EP4 Subtype; Respiratory Mucosa; Sheep; Thiophenes; Trachea; Triazoles | 2011 |
Electrochemical polymerization of (2-dodecyl-4, 7-di (thiophen-2-yl)-2H-benzo[d][1,2,3] triazole): a novel matrix for biomolecule immobilization.
Topics: Amino Acids; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Electrochemistry; Enzymes, Immobilized; Glucose Oxidase; Kinetics; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Oxygen Consumption; Polymerization; Thiophenes; Triazoles; Yeasts | 2010 |
Potent and selective 5-LO inhibitor bearing benzothiophene pharmacophore: discovery of MK-5286.
Topics: Administration, Oral; Animals; Arachidonate 5-Lipoxygenase; Dogs; Drug Evaluation, Preclinical; Humans; Hydrocarbons, Fluorinated; Lipoxygenase Inhibitors; Rats; Structure-Activity Relationship; Thiophenes; Triazoles | 2010 |
Studying synergism of methyl linked cyclohexyl thiophenes with triazole: synthesis and their cdk5/p25 inhibition activity.
Topics: Cyclin-Dependent Kinase 5; Drug Synergism; Humans; Molecular Structure; Nerve Tissue Proteins; Stereoisomerism; Structure-Activity Relationship; Thiophenes; Triazoles | 2011 |
Synthesis and chemical characterisation of some new diheteroaryl thienothiophene derivatives.
Topics: Imidazoles; Pyrazoles; Pyrimidines; Thiophenes; Transition Temperature; Triazoles | 2011 |
Triazole-linked-thiophene conjugate of calix[4]arene: its selective recognition of Zn2+ and as biomimetic model in supporting the events of the metal detoxification and oxidative stress involving metallothionein.
Topics: Biomimetics; Buffers; Calixarenes; Crystallography, X-Ray; Electrons; Humans; Hydrogen Peroxide; Imines; Inactivation, Metabolic; Magnetic Resonance Spectroscopy; Metallothionein; Models, Molecular; Oxidative Stress; Quantum Theory; Spectrometry, Fluorescence; Spectrometry, Mass, Electrospray Ionization; Thermodynamics; Thiophenes; Triazoles; Zinc | 2011 |
Biochemical study of the comparative inhibition of hepatitis C virus RNA polymerase by VX-222 and filibuvir.
Topics: Antiviral Agents; Binding Sites; Cell Line, Tumor; Cyclohexanols; Drug Resistance, Viral; Enzyme Inhibitors; Hepacivirus; Humans; Models, Molecular; Mutation; Pyrones; Replicon; RNA-Dependent RNA Polymerase; RNA, Viral; Templates, Genetic; Thiophenes; Triazoles | 2012 |
Discovery and synthesis of hydronaphthoquinones as novel proteasome inhibitors.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Chymotrypsin; Drug Stability; Humans; Naphthoquinones; Proteasome Inhibitors; Rabbits; Small Molecule Libraries; Structure-Activity Relationship; Sulfonamides; Tetrazoles; Thioglycolates; Thiophenes; Triazoles | 2012 |
Autocrine prostaglandin E2 signaling promotes tumor cell survival and proliferation in childhood neuroblastoma.
Topics: 16,16-Dimethylprostaglandin E2; Autocrine Communication; Biphenyl Compounds; Blotting, Western; Calcium; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclic AMP; Cyclooxygenase 2 Inhibitors; Dinoprostone; Humans; Immunohistochemistry; In Vitro Techniques; Neuroblastoma; Phosphorylation; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP3 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Reverse Transcriptase Polymerase Chain Reaction; Tandem Mass Spectrometry; Thiophenes; Triazoles | 2012 |
Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
Topics: Ascomycota; Dioxolanes; Drug Resistance, Fungal; Fungicides, Industrial; Microbial Sensitivity Tests; Organosilicon Compounds; Plant Diseases; Thiophenes; Triazoles; Triticum | 2012 |
Design, synthesis, and structure-activity correlations of novel dibenzo[b,d]furan, dibenzo[b,d]thiophene, and N-methylcarbazole clubbed 1,2,3-triazoles as potent inhibitors of Mycobacterium tuberculosis.
Topics: Antitubercular Agents; Benzofurans; Carbazoles; Cell Line, Tumor; Click Chemistry; Cytostatic Agents; Drug Design; Humans; Mycobacterium tuberculosis; Thiophenes; Triazoles | 2012 |
Exploration of cathepsin S inhibitors characterized by a triazole P1-P2 amide replacement.
Topics: Amides; Cathepsins; Half-Life; Humans; Microsomes, Liver; Protease Inhibitors; Protein Binding; Structure-Activity Relationship; Thiophenes; Triazoles | 2012 |
Activation of prostaglandin E receptor 4 triggers secretion of gut hormone peptides GLP-1, GLP-2, and PYY.
Topics: Animals; Cells, Cultured; Gastric Inhibitory Polypeptide; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Intestinal Mucosa; Mice; Peptide YY; Real-Time Polymerase Chain Reaction; Receptors, Prostaglandin E, EP4 Subtype; Thiophenes; Triazoles | 2013 |
Synthesis and biological evaluation of thieno [2',3':4,5]pyrimido[1,2-b][1,2,4]triazines and thieno[2,3-d][1,2,4]triazolo[1,5-a]pyrimidines as anti-inflammatory and analgesic agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Edema; Formaldehyde; Male; Molecular Structure; Pyrimidines; Rats; Rats, Wistar; Structure-Activity Relationship; Thiophenes; Triazines; Triazoles | 2013 |
New annelated thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidines, with potent anticancer activity, designed through VLAK protocol.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Pyrimidines; Structure-Activity Relationship; Thiophenes; Triazoles | 2013 |
Coculture with endothelial cells enhances osteogenic differentiation of periodontal ligament stem cells via cyclooxygenase-2/prostaglandin E2/vascular endothelial growth factor signaling under hypoxia.
Topics: Angiogenesis Inhibitors; Cell Culture Techniques; Cell Differentiation; Cell Hypoxia; Coculture Techniques; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Endothelial Cells; Flavonoids; Human Umbilical Vein Endothelial Cells; Humans; Indoles; Nitrobenzenes; Osteogenesis; Periodontal Ligament; Prostaglandin Antagonists; Protein Kinase Inhibitors; Pyrroles; Signal Transduction; Stem Cells; Sulfonamides; Thiophenes; Triazoles; Vascular Endothelial Growth Factor A; Xanthones | 2013 |
The top 10 drug trends right now.
Topics: Ado-Trastuzumab Emtansine; Antibodies, Monoclonal, Humanized; Azepines; Biphenyl Compounds; Canagliflozin; Cholesterol Ester Transfer Proteins; Dimethyl Fumarate; Drug Approval; Forecasting; Fumarates; gamma-Cyclodextrins; Glucosides; Humans; Lactones; Maytansine; Pyridines; Sofosbuvir; Sugammadex; Thiophenes; Trastuzumab; Triazoles; United States; United States Food and Drug Administration; Uridine Monophosphate | 2013 |
High-crystalline medium-band-gap polymers consisting of benzodithiophene and benzotriazole derivatives for organic photovoltaic cells.
Topics: Electrochemical Techniques; Fullerenes; Polymers; Polystyrenes; Quantum Theory; Solar Energy; Spectrum Analysis, Raman; Thiophenes; Tin Compounds; Triazoles | 2013 |
Regulation of rat intrapulmonary arterial tone by arachidonic acid and prostaglandin E2 during hypoxia.
Topics: Animals; Arachidonic Acid; Calcium; Cyclic AMP; Cyclooxygenase 2; Dinoprostone; Hypoxia; Male; Muscle Tonus; Oxytocics; Pulmonary Artery; Rats; Rats, Wistar; Receptors, Prostaglandin E; Thiophenes; Triazoles; Vasoconstriction; Xanthones | 2013 |
Post-infection activities of fungicides against Cercospora arachidicola of peanut (Arachis hypogaea).
Topics: Arachis; Ascomycota; Carbamates; Fungicides, Industrial; Plant Diseases; Pyrazoles; Strobilurins; Thiophenes; Triazoles | 2014 |
Targeting small cell lung cancer harboring PIK3CA mutation with a selective oral PI3K inhibitor PF-4989216.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Class I Phosphatidylinositol 3-Kinases; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Humans; Immunoblotting; Lung Neoplasms; Mice; Mice, SCID; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Small Cell Lung Carcinoma; Thiophenes; Triazoles; Xenograft Model Antitumor Assays | 2014 |
Vitamin a is a negative regulator of osteoblast mineralization.
Topics: Animals; Benzoates; Benzothiazoles; Calcification, Physiologic; Cell Line; Core Binding Factor Alpha 1 Subunit; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Femur; Humans; Male; Osteoblasts; Rats; Rats, Sprague-Dawley; Receptors, Retinoic Acid; Retinoic Acid 4-Hydroxylase; Signal Transduction; Sp7 Transcription Factor; Thiophenes; Transcription Factors; Triazoles; Vitamin A; Vitamins | 2013 |
Use of vibrational spectroscopy to study 4-benzyl-3-(thiophen-2-yl)-4,5-dihydro-1H-1,2,4-triazole-5-thione: A combined theoretical and experimental approach.
Topics: Models, Molecular; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Thiones; Thiophenes; Triazoles | 2014 |
Thiophenyl-substituted triazolyl-thione L-alanine: asymmetric synthesis, aggregation and biological properties.
Topics: Alanine; Amino Acids, Aromatic; Antiviral Agents; Circular Dichroism; Drug Design; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; Nephelometry and Turbidimetry; RNA; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Thiophenes; Triazoles | 2014 |
New thiophene-1,2,4-triazole-5(3)-ones: highly bioactive thiosemicarbazides, structures of Schiff bases and triazole-thiols.
Topics: Anti-Bacterial Agents; Antioxidants; Bacillus cereus; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium smegmatis; Schiff Bases; Semicarbazides; Staphylococcus aureus; Structure-Activity Relationship; Sulfhydryl Compounds; Thiophenes; Triazoles | 2014 |
Synthesis and antioxidant activities of some new triheterocyclic compounds containing benzimidazole, thiophene, and 1,2,4-triazole rings.
Topics: Antioxidants; Benzimidazoles; Dose-Response Relationship, Drug; Heterocyclic Compounds; Molecular Structure; Structure-Activity Relationship; Thiophenes; Triazoles | 2015 |
Synthesis and antiproliferative activity of some new thieno[2,3-d]pyrimidin-4(3H)-ones containing 1,2,4-triazole and 1,3,4-thiadiazole moiety.
Topics: Antineoplastic Agents; Cell Line; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HeLa Cells; Hep G2 Cells; HT29 Cells; Humans; Molecular Structure; Pyrimidinones; Structure-Activity Relationship; Thiadiazoles; Thiophenes; Triazoles | 2014 |
Cross-genotypic examination of hepatitis C virus polymerase inhibitors reveals a novel mechanism of action for thumb binders.
Topics: Antiviral Agents; Benzimidazoles; Benzofurans; Cyclohexanols; Drug Resistance, Viral; Enzyme Inhibitors; Genotype; Hepacivirus; Humans; Purines; Pyridazines; Pyrones; Recombinant Proteins; Replicon; RNA-Dependent RNA Polymerase; Structure-Activity Relationship; Sulfonamides; Thiophenes; Triazoles; Viral Proteins | 2014 |
Triazole-based compound as a candidate to develop novel medicines to treat toxoplasmosis.
Topics: Animals; Antiprotozoal Agents; Cell Line; Dose-Response Relationship, Drug; Fibroblasts; HeLa Cells; Humans; Inhibitory Concentration 50; Mice; Molecular Docking Simulation; Parasitic Sensitivity Tests; Protozoan Proteins; Purine-Nucleoside Phosphorylase; Structure-Activity Relationship; Sulfadiazine; Thiophenes; Toxoplasma; Triazoles | 2014 |
Evidence for the chain-growth synthesis of statistical π-conjugated donor-acceptor copolymers.
Topics: Catalysis; Models, Chemical; Nickel; Oxidation-Reduction; Polymerization; Polymers; Quantum Theory; Thiophenes; Triazoles | 2015 |
Prostaglandin potentiates 5-HT responses in stomach and ileum innervating visceral afferent sensory neurons.
Topics: Animals; Anti-Inflammatory Agents; Carbazoles; Dinoprostone; Dose-Response Relationship, Drug; Gastrointestinal Diseases; Ileum; Male; Neurons, Afferent; Nodose Ganglion; Ondansetron; Patch-Clamp Techniques; Prostaglandins; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Serotonin, 5-HT3; Sensory Receptor Cells; Serotonin; Signal Transduction; Stomach; Thiophenes; Triazoles; Visceral Afferents; Xanthones | 2015 |
EP2 and EP4 receptors mediate PGE2 induced relaxation in murine colonic circular muscle: pharmacological characterization.
Topics: Alprostadil; Animals; Azetidines; Colon; Dinoprostone; Female; In Vitro Techniques; Male; Mice, Knockout; Muscle Contraction; Muscle, Smooth; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Thiophenes; Triazoles | 2014 |
Activation of prostaglandin E2-EP4 signaling reduces chemokine production in adipose tissue.
Topics: Adipose Tissue; Animals; Chemokine CCL3; Chemokine CXCL10; Chemokines; Dinoprostone; In Vitro Techniques; Interleukin-10; Interleukin-6; Interleukin-8; Male; Pyrrolidinones; Receptors, Prostaglandin E, EP4 Subtype; Serum Amyloid A Protein; Signal Transduction; Tetrazoles; Thiophenes; Triazoles | 2015 |
Antagonist of prostaglandin E2 receptor 4 induces metabolic alterations in liver of mice.
Topics: Animals; Liver; Male; Mice; Mice, Inbred BALB C; Proton Magnetic Resonance Spectroscopy; Receptors, Prostaglandin E, EP4 Subtype; Thiophenes; Triazoles | 2015 |
Prostaglandin E2 promotes proliferation of skeletal muscle myoblasts via EP4 receptor activation.
Topics: Acetylcysteine; Alprostadil; Animals; Cell Proliferation; Cells, Cultured; Dinoprostone; G1 Phase Cell Cycle Checkpoints; Immunohistochemistry; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Myoblasts; Reactive Oxygen Species; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP3 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Signal Transduction; Thiophenes; Triazoles | 2015 |
Prostanoids regulate angiogenesis acting primarily on IP and EP4 receptors.
Topics: Benzyl Compounds; Cell Movement; Dinoprostone; Endothelial Cells; Epoprostenol; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Neovascularization, Pathologic; Neovascularization, Physiologic; Prostaglandins I; Real-Time Polymerase Chain Reaction; Receptors, Epoprostenol; Receptors, G-Protein-Coupled; Receptors, Prostaglandin E, EP4 Subtype; Thiophenes; Triazoles; Xanthones | 2015 |
Design, synthesis and biological evaluation of novel 1,2,4-triazolo [3,4-b][1,3,4] thiadiazines bearing furan and thiophene nucleus.
Topics: Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Furans; Hep G2 Cells; Humans; Molecular Structure; Structure-Activity Relationship; Thiadiazines; Thiophenes; Triazoles | 2015 |
Combined, but not individual, blockade of ASIC3, P2X, and EP4 receptors attenuates the exercise pressor reflex in rats with freely perfused hindlimb muscles.
Topics: Acid Sensing Ion Channels; Animals; Blood Pressure; Cnidarian Venoms; Decerebrate State; Hindlimb; Muscle, Skeletal; Neurons, Afferent; Physical Exertion; Purinergic P2X Receptor Antagonists; Pyridoxal Phosphate; Rats; Receptors, Prostaglandin E, EP4 Subtype; Receptors, Purinergic P2X; Reflex; Thiophenes; Triazoles | 2015 |
Efficient Hole-Transporting Materials with Triazole Core for High-Efficiency Perovskite Solar Cells.
Topics: Calcium Compounds; Electric Power Supplies; Electrons; Equipment Design; Oxides; Solar Energy; Thiophenes; Titanium; Triazoles | 2016 |
Crystal Structures of KPC-2 and SHV-1 β-Lactamases in Complex with the Boronic Acid Transition State Analog S02030.
Topics: beta-Lactamase Inhibitors; beta-Lactamases; Boronic Acids; Carbapenems; Catalytic Domain; Cephalosporins; Crystallography, X-Ray; Klebsiella pneumoniae; Protein Structure, Tertiary; Thiophenes; Triazoles | 2016 |
The Knoevenagel reaction of cyanoacetylhydrazine with pregnenolone: Synthesis of thiophene, thieno[2,3-d]pyrimidine, 1,2,4-triazole, pyran and pyridine derivatives with anti-inflammatory and anti-ulcer activities.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Hydrazines; Pandalidae; Pregnenolone; Thiophenes; Triazoles | 2016 |
BLOCKADE OF PGE2, PGD2 RECEPTORS CONFERS PROTECTION AGAINST PREPATENT SCHISTOSOMIASIS MANSONI IN MICE.
Topics: Animals; Cytokines; Gene Expression Regulation; Indoles; Mice; Mice, Inbred C57BL; Prostaglandin Antagonists; Receptors, Immunologic; Receptors, Prostaglandin; Receptors, Prostaglandin E; Schistosomiasis mansoni; T-Lymphocytes, Helper-Inducer; Thiophenes; Triazoles; Xanthones | 2015 |
Hydrogen/Deuterium Exchange Kinetics Demonstrate Long Range Allosteric Effects of Thumb Site 2 Inhibitors of Hepatitis C Viral RNA-dependent RNA Polymerase.
Topics: Allosteric Regulation; Binding Sites; Deuterium Exchange Measurement; Furans; Hepacivirus; Kinetics; Pyrones; RNA-Dependent RNA Polymerase; RNA, Viral; Thiophenes; Triazoles; Viral Nonstructural Proteins | 2016 |
PGE2 released by primary sensory neurons modulates Toll-like receptor 4 activities through an EP4 receptor-dependent process.
Topics: Animals; Cells, Cultured; Culture Media, Conditioned; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Ganglia, Spinal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Lipopolysaccharide Receptors; Lipopolysaccharides; Male; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E, EP4 Subtype; Sensory Receptor Cells; Sulfonamides; Thiophenes; Toll-Like Receptor 4; Triazoles; Tumor Necrosis Factor-alpha | 2016 |
Click-based synthesis and antitubercular evaluation of novel dibenzo[b,d]thiophene-1,2,3-triazoles with piperidine, piperazine, morpholine and thiomorpholine appendages.
Topics: Antitubercular Agents; Cell Survival; Click Chemistry; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Molecular Structure; Morpholines; Mycobacterium tuberculosis; Piperazine; Piperazines; Piperidines; Structure-Activity Relationship; Thiophenes; Triazoles | 2016 |
New drugs 2016, part 2.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Benzimidazoles; Carbamates; Drug Approval; Drug Therapy; Humans; Imidazoles; Nitriles; Pyridines; Pyrrolidines; Quinolones; Thiophenes; Triazoles; United States; United States Food and Drug Administration; Valine | 2016 |
Contribution of prostanoid signaling to the evolution of spreading depolarization and the associated cerebral blood flow response.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Laser-Doppler Flowmetry; Male; Nitrobenzenes; Prosencephalon; Prostaglandins; Pyrazoles; Rats; Rats, Sprague-Dawley; Signal Transduction; Sulfonamides; Thiophenes; Triazoles | 2016 |
Identification of novel Trypanosoma cruzi prolyl oligopeptidase inhibitors by structure-based virtual screening.
Topics: Animals; Benzene Derivatives; Binding Sites; Catalytic Domain; Databases, Chemical; Humans; Molecular Dynamics Simulation; Molecular Structure; Prolyl Oligopeptidases; Protein Binding; Pyrimidines; Sequence Homology, Amino Acid; Serine Endopeptidases; Serine Proteinase Inhibitors; Small Molecule Libraries; Structure-Activity Relationship; Sulfonamides; Swine; Thiophenes; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach.
Topics: Animals; Cartilage; Cattle; Chelating Agents; Collagen; Drug Design; Matrix Metalloproteinase 13; Matrix Metalloproteinase Inhibitors; Pyrimidines; Pyrimidinones; Quinazolines; Thiophenes; Triazoles; Zinc | 2017 |
Comprehensive understanding of acetohydroxyacid synthase inhibition by different herbicide families.
Topics: Acetolactate Synthase; Arabidopsis Proteins; Benzoates; Catalytic Domain; Crystallography, X-Ray; Herbicides; Imidazoles; Kinetics; Models, Molecular; Molecular Structure; Protein Binding; Protein Conformation; Pyrimidines; Quinolines; Sulfonylurea Compounds; Thiamine Pyrophosphate; Thiophenes; Triazoles | 2017 |
The EP4 antagonist, L-161,982, induces apoptosis, cell cycle arrest, and inhibits prostaglandin E2-induced proliferation in oral squamous carcinoma Tca8113 cells.
Topics: Apoptosis; Carcinoma, Squamous Cell; Cell Cycle Checkpoints; Cell Proliferation; Dinoprostone; Humans; Mouth Neoplasms; Receptors, Prostaglandin E, EP4 Subtype; Thiophenes; Triazoles; Tumor Cells, Cultured | 2017 |
Overexpression of ATP-Binding Cassette Subfamily G Member 2 Confers Resistance to Phosphatidylinositol 3-Kinase Inhibitor PF-4989216 in Cancer Cells.
Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Line, Tumor; Drug Resistance, Neoplasm; HEK293 Cells; Humans; MCF-7 Cells; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; Thiophenes; Triazoles | 2017 |
L161982 alleviates collagen-induced arthritis in mice by increasing Treg cells and down-regulating Interleukin-17 and monocyte-chemoattractant protein-1 levels.
Topics: Animals; Ankle Joint; Arthritis, Experimental; Arthritis, Rheumatoid; Celecoxib; Cell Differentiation; Cell Proliferation; Chemokine CCL2; Collagen Type II; Cyclooxygenase 2 Inhibitors; Dinoprostone; Down-Regulation; Female; Humans; Injections, Intraperitoneal; Interleukin-17; Mice; Mice, Inbred DBA; Receptors, Prostaglandin E, EP4 Subtype; Severity of Illness Index; Signal Transduction; T-Lymphocytes, Regulatory; Th17 Cells; Thiophenes; Triazoles | 2017 |
Plk1 Inhibition Enhances the Efficacy of BET Epigenetic Reader Blockade in Castration-Resistant Prostate Cancer.
Topics: Animals; Azepines; beta Catenin; Cell Cycle Proteins; Cell Line, Tumor; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Nuclear Proteins; Polo-Like Kinase 1; Prostatic Neoplasms, Castration-Resistant; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; Receptors, Androgen; Signal Transduction; Thiophenes; Transcription Factors; Triazoles; Xenograft Model Antitumor Assays | 2018 |
Facile One-Pot Parallel Synthesis of 3-Amino-1,2,4-triazoles.
Topics: Alkylation; Molecular Structure; Small Molecule Libraries; Temperature; Thiophenes; Thiourea; Time Factors; Triazoles | 2018 |
Does sea-dyke construction affect the spatial distribution of pesticides in agricultural soils? - A case study from the Red River Delta, Vietnam.
Topics: Agriculture; Chlorpyrifos; Environmental Monitoring; Environmental Pollution; Floods; Oryza; Pesticides; Pyrimidines; Rivers; Soil; Soil Pollutants; Specimen Handling; Strobilurins; Thiophenes; Triazoles; Vietnam; Water Pollutants, Chemical | 2018 |
Impact of foliar fungicides on target and non-target soil microbial communities in cucumber crops.
Topics: Benzamides; Crops, Agricultural; Cucumis sativus; Fungicides, Industrial; Microbiota; Plant Diseases; Pyrazoles; Pyridines; Soil; Soil Microbiology; Thiophenes; Triazoles | 2018 |
Synthesis, computational quantum chemical study, in silico ADMET and molecular docking analysis, in vitro biological evaluation of a novel sulfur heterocyclic thiophene derivative containing 1,2,3-triazole and pyridine moieties as a potential human topois
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Density Functional Theory; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Heterocyclic Compounds; Humans; Molecular Docking Simulation; Molecular Structure; Poly-ADP-Ribose Binding Proteins; Pyridines; Structure-Activity Relationship; Sulfur; Thiophenes; Topoisomerase II Inhibitors; Triazoles | 2019 |
Enhancement by Hydrogen Peroxide of Calcium Signals in Endothelial Cells Induced by 5-HT1B and 5-HT2B Receptor Agonists.
Topics: Acetylcysteine; Benzoxazoles; Calcium; Calcium Signaling; Fluorescence; Human Umbilical Vein Endothelial Cells; Humans; Hydrogen Peroxide; Indoles; Quinoxalines; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT2B; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT2 Receptor Agonists; Thiophenes; Triazoles; Vanadates | 2019 |
Novel Application of Pentabromobenzyl Column for Simultaneous Determination of Eight Antifungal Drugs Using High-performance Liquid Chromatography.
Topics: Antifungal Agents; Chromatography, High Pressure Liquid; Clotrimazole; Humans; Hydrocarbons, Brominated; Imidazoles; Ketoconazole; Liquid-Liquid Extraction; Molecular Structure; Thiophenes; Triazoles; Voriconazole | 2020 |
Inhibition of Urea Transporter (UT)-B Modulates LPS-Induced Inflammatory Responses in BV2 Microglia and N2a Neuroblastoma Cells.
Topics: Animals; Cell Line, Tumor; Inflammation; Interleukin-6; Lipopolysaccharides; Membrane Transport Proteins; Mice; Microglia; Neuroblastoma; Nitric Oxide; Pyrimidines; Thiophenes; Triazoles; Tumor Necrosis Factor-alpha; Urea Transporters | 2021 |
Metabolic drug survey highlights cancer cell dependencies and vulnerabilities.
Topics: Biomarkers, Tumor; Cell Survival; Cluster Analysis; Fatty Acids; Genotype; Humans; Leukemia, Myeloid; Monocarboxylic Acid Transporters; Phenotype; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Pyrimidinones; Pyrrolidines; Signal Transduction; Small Molecule Libraries; Symporters; Systems Analysis; Thiophenes; Triazoles; Tumor Cells, Cultured | 2021 |
Factors Affecting the Stability of Platinum(II) Complexes with 1,2,4-Triazolo[1,5-
Topics: Antineoplastic Agents; Benzene Derivatives; Cell Line, Tumor; Oxides; Platinum; Pyrimidines; Sulfoxides; Thiophenes; Triazoles | 2022 |
Evaluation of Anthelmintic and Anti-Inflammatory Activity of 1,2,4-Triazole Derivatives.
Topics: Anthelmintics; Anti-Infective Agents; Anti-Inflammatory Agents; Humans; Imidazoles; Leukocytes, Mononuclear; Sulfonamides; Thiophenes; Triazoles; Tumor Necrosis Factor-alpha | 2022 |
Synthesis, Biological Activity and Molecular Docking Studies of Heterocyclic Chalcones.
Topics: Aldehydes; Anti-Infective Agents; Antineoplastic Agents; Candida albicans; Chalcone; Chalcones; Imidazoles; Indoles; Molecular Docking Simulation; Molecular Structure; Pyrazoles; Staphylococcus aureus; Structure-Activity Relationship; Thiophenes; Triazoles | 2022 |