Myotonia

Prolonged failure of muscle relaxation after contraction. This may occur after voluntary contractions, muscle percussion, or electrical stimulation of the muscle. Myotonia is a characteristic feature of MYOTONIC DISORDERS.

Synonym
Myotonia
Myotonic Phenomenon
Percussion Myotonia

Excerpt	Reference
"While myotonia is the result of a primary defect in the muscle membrane, these experiments indicate the innervation is necessary to maintain the muscle membrane in a state that will support myotonia."	( Fenichel, G; Iyer, V; Whiting, M, 1977)
"Pseudomyotonia is a syndrome characterized by progressive muscle stiffness, weakness, myokymia, hyperhydrosis, and wasting of muscle."	( Canalis, RF; Kaplan, HJ; Levinson, S, 1976)
"Neuromyotonia is a rare condition of peripheral nerve dysfunction characterized by the signs of motor nerve hyperactivity, namely, myokymia, fasciculations, and muscular stiffness."	( Feldmann, M; Kukowski, B, 1992)
"Myotonia is defined as a persistent contraction of skeletal muscles after their stimulation."	( Lienhart, A, 1989)
"Myotonia is characterized by prolonged contraction (delay in onset of relaxation) of skeletal muscle fibers with characteristic electromyographic findings."	( al-Rajeh, S; Iyer, V; Olson, WH, 1989)
"Insertion myotonia is ceased by addition of the Na channel blocker tetrotoxin."	( Kinoshita, M; Kishi, M; Kurihara, T; Uchida, H, 1989)
"Acquired neuromyotonia is characterized by hyperexcitability of motor nerves leading to muscle twitching, cramps, and weakness."	( Chauplannaz, G; Leys, K; Molenaar, PC; Plomp, JJ; Shillito, P; van den Berg, RJ; van Kempen, GT; Vincent, A; Wintzen, AR; Zheng, W, 1995)
"Pseudo-myotonia is the most important clinical feature."	( Benders, AA; Bindels, RJ; Busch, HF; Jongen, PJ; Oosterhof, A; Smit, LM; Veerkamp, JH; Wevers, RA, 1994)
"Ocular neuromyotonia is characterised by spontaneous spasm of extraocular muscles and has been described in only 14 patients."	( Ezra, E; Graham, EM; Plant, GT; Sanders, MD; Spalton, D, 1996)
"Ocular neuromyotonia is described in 2 patients with dysthyroid orbitopathy, confirming previous findings."	( Chung, SM; Cruz, OA; Holds, JB; Lee, AG; Roper-Hall, G, 1997)
"However myotonia is rarely a revealing feature."	( Masmoudi, S; Mrabet, A; Mrabet, H, 2007)
"Myotonia is an early, prominent symptom in DM1 and contributes to decreased dexterity, gait instability, difficulty with speech/swallowing, and muscle pain."	( Annis, CL; Barbieri, CA; Dilek, N; Logigian, EL; Martens, WB; McDermott, MP; Moxley, RT; Pearson, AT; Thornton, CA; Wiegner, AW, 2010)
"Non-dystrophic myotonias are rare diseases caused by mutations in skeletal muscle chloride and sodium ion channels with considerable phenotypic overlap between diseases."	( Amato, A; Barohn, RJ; Bundy, B; Cannon, S; Cleland, J; Fialho, D; Gorham, N; Griggs, RC; Hanna, MG; Herbelin, L; Matthews, E; Rayan, DR; Salajegheh, M; Statland, J; Trivedi, JR; Venance, SL; Wang, Y, 2013)
"Myotonia is a skeletal muscle condition characterized by the over-excitability of the sarcolemma, resulting in delayed relaxation after contraction and muscle stiffness."	( Boccanegra, B; Cerchiara, AG; De Bellis, M; De Luca, A; Imbrici, P, 2023)
"Clinical myotonia is uncommon."	( Brito, LA; Freitas, HC; Landim, JID; Maia, IHM; Oliveira, EB; Ribeiro, IS; Rodrigues, CL; Távora, DGF, 2023)

Excerpt	Reference
"Hitherto, myotonia has been considered peculiar to homeotherms where it is associated with several hereditable diseases and can be induced by specific treatments, most of which seem to act by decreasing membrane chloride conductance."	( Bretag, AH; Dawe, SR; Moskwa, AG, 1980)
"To date, myotonia has not been described in this disorder."	( De Girolami, U; Freeman, R; Gouras, GK; Johns, DR; Nardin, RA; Preston, DC; Raynor, EM; Rutkove, SB, 1996)

Excerpt	Reference
"The symptomatic treatment of myotonia and myalgia in patients with dystrophic and non-dystrophic myotonias is often not satisfactory."	( Montagnese, F; Schoser, B; Stahl, K; Wenninger, S, 2020)
"Although mexiletine effectively treats myotonia, supply disruptions affected Europe between 2008-2018."	( Díaz-Manera, J; Foerster, D; Kole, A; Schey, C; Urtizberea, JA; von Gallwitz, P; Whiting, A; Zozulya-Weidenfeller, A, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	288 (66.21)	23.3326
1990's	80 (18.39)	12.5806
2000's	29 (6.67)	18.1394
2010's	24 (5.52)	28.8240
2020's	14 (3.22)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	2	0
carnitine	low	2	0
chlorine	low	34	0
creatine	low	3	0
lactic acid	low	1	0
glycine	low	3	0
histamine	low	1	0
indole	low	1	0
indoleacetic acid	low	1	0
iodine	low	1	0
kynurenine	low	1	0
nitrous oxide	low	2	0
triphosphoric acid	low	1	0
pyridoxal	low	1	0
pyridoxine	low	1	0
taurine	medium	2	1
uracil	low	1	0
1-anilino-8-naphthalenesulfonate	low	1	0
2,4-dichlorophenoxyacetic acid	low	24	0
4-aminopyridine	low	2	0
phenytoin	medium	20	1
hydroxyindoleacetic acid	low	1	0
acetaminophen	low	1	0
acetazolamide	medium	11	1
theophylline	low	1	0
amitriptyline	low	2	0
9-anthroic acid	low	13	0
baclofen	medium	1	1
caffeine	low	2	0
verapamil	low	1	0
carbamazepine	low	18	0
chlordiazepoxide	low	1	0
chlormezanone	low	1	0
chlorothiazide	medium	2	1
chlorpromazine	low	5	0
clofibrate	low	8	0
clomipramine	medium	1	1
dantrolene	low	4	0
diazepam	low	7	0
dicamba	low	1	0
diphenhydramine	low	1	0
disopyramide	medium	1	1
disulfiram	low	1	0
berotek	low	1	0
flecainide	low	2	0
furosemide	low	1	0
gabapentin	low	1	0
glyphosate	low	1	0
1-(5-isoquinolinesulfonyl)-2-methylpiperazine	low	1	0
haloperidol	low	1	0
halothane	low	8	0
hydrochlorothiazide	low	1	0
lidocaine	low	10	0
isoflurane	low	1	0
ketamine	low	1	0
lamotrigine	low	1	0
mephenesin	low	1	0
methocarbamol	low	1	0
metoclopramide	low	1	0
mexiletine	medium	28	5
moxisylyte	low	1	0
ethylmaleimide	low	1	0
neostigmine	low	5	0
nicardipine	low	1	0
nifedipine	medium	3	1
orphenadrine	low	1	0
pentobarbital	low	1	0
potassium chloride	medium	6	1
potassium iodide	low	1	0
4-aminobenzoic acid	low	1	0
procainamide	low	14	0
procaine	low	2	0
propofol	low	3	0
propranolol	low	5	0
riluzole	low	1	0
sevoflurane	low	1	0
succinylcholine	low	24	0
tolazoline	low	1	0
tolperisone	low	1	0
prednisolone	low	1	0
reserpine	low	2	0
thyroxine	low	7	0
dextroamphetamine	low	1	0
spironolactone	low	2	0
penicillamine	low	1	0
prednisone	low	8	0
dehydroepiandrosterone	low	1	0
pilocarpine	low	1	0
alanine	low	1	0
serine	low	1	0
tubocurarine	low	6	0
adenosine diphosphate	low	2	0
uridine	low	2	0
phenylephrine	low	1	0
levodopa	low	1	0
edetic acid	low	3	0
zoxazolamine	low	1	0
leucine	low	1	0
methionine	low	4	0
phenylalanine	low	1	0
colchicine	low	5	0
gallamine triethiodide	low	2	0
egtazic acid	low	1	0
valine	low	4	0
tryptophan	low	1	0
isoleucine	low	1	0
arginine	low	3	0
triparanol	low	5	0
methylprednisolone	low	2	0
2-methyl-4-chlorophenoxyacetic acid	low	1	0
pyridostigmine bromide	low	1	0
methylergonovine	low	1	0
hexachlorobenzene	low	3	0
acridines	low	1	0
thiazoles	low	1	0
trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane dihydrochloride	low	2	0
betamethasone	low	1	0
hydantoins	low	4	0
dehydroepiandrosterone sulfate	low	3	0
benzohexonium	medium	1	1
thorium dioxide	low	1	0
d-alpha tocopherol	low	1	0
s,n,n'-tripropylthiocarbamate	low	1	0
dronabinol	low	1	0
tetrahydropapaveroline	low	1	0
dithiothreitol	low	1	0
nafenopin	low	1	0
metocurine	low	1	0
iodinated glycerol	low	1	0
cadmium	low	1	0
vanadium	low	1	0
magnesium sulfate	low	1	0
trolamine salicylate	low	1	0
fluorides	low	1	0
iodine	low	2	0
phenyl acetate	low	4	0
triamcinolone	low	1	0
du-21220	low	1	0
glutamic acid	low	1	0
torpedo	low	2	0
phorbol 12,13-dibutyrate	low	1	0
tocainide	medium	13	1
diltiazem	low	1	0
propiconazole	low	2	0
colforsin	low	1	0
fomesafen	low	4	0
lovastatin	low	1	0
simvastatin	low	3	0
pravastatin	low	2	0
fosphenytoin	low	1	0
lubeluzole	low	1	0
triazoles	low	1	0
trypan red	low	1	0
leucinocaine mesylate	low	1	0
rufinamide	low	1	0
safinamide	low	1	0
atropine	low	2	0
lacosamide	low	1	0
cortisone	low	2	0
glycogen	low	4	0
oxytocin	low	2	0
ouabain	low	14	0
desmosterol	low	14	0
quinidine	low	2	0
pancuronium	low	2	0
cannabidiol	low	1	0
thiopental	low	1	0
lithium	low	1	0
quinine	low	9	0
sodium dodecyl sulfate	low	1	0
17-ketosteroids	low	3	0
amphotericin b	low	1	0
lysophosphatidylcholines	low	1	0
phosphorus	low	1	0
ajmaline	low	2	0
tetrodotoxin	low	4	0
butylscopolammonium bromide	low	1	0
staurosporine	low	1	0
azacosterol	low	15	0
veratridine	low	1	0
calcimycin	low	1	0
pituitrin	low	1	0
dihydrotachysterol	low	1	0
acid phosphatase	low	2	0
nad	low	1	0
cosyntropin	low	1	0
glucagon	low	1	0
phosphatidylcholines	low	1	0
ubiquinone	low	2	0
k-strophanthin-beta	low	1	0
sodium oxybate	medium	1	1
cardiovascular agents	low	2	0
glycolipids	low	2	0
piperidines	low	3	0
toxin ii (anemonia sulcata)	low	3	0
caseins	low	1	0
nitrophenols	low	1	0
guanine	low	1	0
phosphorus radioisotopes	low	1	0
phenanthrenes	low	1	0

Protein Targets (1,358)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	34	0	0	34
thioredoxin reductase	48	0	0	48
ATAD5 protein, partial	18	0	0	18
GLS protein	33	0	0	33
TDP1 protein	47	0	0	47
regulator of G-protein signaling 4	31	0	0	31
67.9K protein	7	0	0	7
Parkin	9	0	0	9
bromodomain adjacent to zinc finger domain 2B	9	0	0	9
IDH1	22	0	0	22
euchromatic histone-lysine N-methyltransferase 2	63	0	0	63
nuclear factor erythroid 2-related factor 2 isoform 2	15	0	0	15
huntingtin isoform 2	7	0	0	7
ras-related protein Rab-9A	9	0	0	9
serine/threonine-protein kinase mTOR isoform 1	11	0	0	11
urokinase-type plasminogen activator precursor	11	0	0	11
plasminogen precursor	11	0	0	11
urokinase plasminogen activator surface receptor precursor	11	0	0	11
survival motor neuron protein isoform d	16	0	0	16
D(1A) dopamine receptor	8	2	0	10
Ataxin-2	27	0	0	27
ATP-dependent phosphofructokinase	29	0	0	29
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	7	0	0	7
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	2	0	0	2
USP1 protein, partial	32	0	0	32
vitamin D3 receptor isoform VDRA	19	0	0	19
importin subunit beta-1 isoform 1	5	0	0	5
flap endonuclease 1	16	0	0	16
serine/threonine-protein kinase PLK1	7	0	0	7
snurportin-1	5	0	0	5
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	11	0	0	11
GTP-binding nuclear protein Ran isoform 1	3	0	0	3
DNA polymerase eta isoform 1	4	0	0	4
DNA polymerase iota isoform a (long)	15	0	0	15
geminin	50	0	0	50
DNA polymerase kappa isoform 1	11	0	0	11
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	0	1
Beta-lactamase	0	3	0	3
Transthyretin	0	1	1	3
Fatty acid-binding protein, intestinal	0	1	1	2
Fatty acid-binding protein, adipocyte	0	1	1	2
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	5	2	7
Cyclin-dependent kinase 2	0	1	1	2
Choline O-acetyltransferase	0	1	0	1
Mitogen-activated protein kinase 12	0	1	0	1
Guanine nucleotide-binding protein G	7	0	0	7
Fatty acid-binding protein 5	0	0	1	1
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	1	0	1
Mitogen-activated protein kinase 14	0	2	0	2
Chain A, Beta-lactamase	18	0	0	18
Luciferase	16	0	0	16
RAR-related orphan receptor gamma	51	0	0	51
GLI family zinc finger 3	47	0	0	47
AR protein	64	0	0	64
retinoic acid nuclear receptor alpha variant 1	42	0	0	42
retinoid X nuclear receptor alpha	34	0	0	34
estrogen nuclear receptor alpha	72	0	0	72
peroxisome proliferator activated receptor gamma	36	0	0	36
vitamin D (1,25- dihydroxyvitamin D3) receptor	33	0	0	33
chromobox protein homolog 1	37	0	0	37
thyroid hormone receptor beta isoform 2	40	0	0	40
nuclear factor erythroid 2-related factor 2 isoform 1	45	0	0	45
Inositol monophosphatase 1	10	0	0	10
TAR DNA-binding protein 43	16	0	0	16
Prostaglandin D2 receptor	0	1	0	1
Prostaglandin D2 receptor 2	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	13	0	0	13
SMAD family member 2	16	0	0	16
SMAD family member 3	16	0	0	16
progesterone receptor	31	0	0	31
estrogen-related nuclear receptor alpha	54	0	0	54
peroxisome proliferator-activated receptor delta	27	0	0	27
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial	0	1	0	1
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	0	1	0	1
Chain A, Toluene-4-monooxygenase system protein A	0	1	0	1
Chain A, Cruzipain	8	0	0	8
Microtubule-associated protein tau	20	0	0	20
aldehyde dehydrogenase 1 family, member A1	29	0	0	29
thyroid stimulating hormone receptor	29	0	0	29
estrogen receptor 2 (ER beta)	23	0	0	23
cytochrome P450 family 3 subfamily A polypeptide 4	40	0	0	40
glucocorticoid receptor [Homo sapiens]	51	0	0	51
cytochrome P450 2D6	30	0	0	30
glucocerebrosidase	8	0	0	8
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	15	0	0	15
cytochrome P450 2D6 isoform 1	15	0	0	15
transcriptional regulator ERG isoform 3	5	0	0	5
mitogen-activated protein kinase 1	12	0	0	12
peripheral myelin protein 22	27	0	0	27
lethal factor (plasmid)	12	0	0	12
lamin isoform A-delta10	53	0	0	53
Potassium channel subfamily K member 2	0	6	6	12
Rap guanine nucleotide exchange factor 3	8	0	0	8
Cellular tumor antigen p53	35	0	0	35
Potassium voltage-gated channel subfamily A member 3	0	1	1	2
Acetylcholinesterase	0	1	0	1
Pteridine reductase 1	0	3	0	3
Potassium voltage-gated channel subfamily A member 1	0	4	1	5
Potassium voltage-gated channel subfamily H member 2	0	34	0	34
Chain A, HADH2 protein	15	0	0	15
Chain B, HADH2 protein	15	0	0	15
Chain A, 2-oxoglutarate Oxygenase	15	0	0	15
hypoxia-inducible factor 1 alpha subunit	15	0	0	15
nuclear receptor subfamily 1, group I, member 3	39	0	0	39
alpha-galactosidase	6	0	0	6
v-jun sarcoma virus 17 oncogene homolog (avian)	28	0	0	28
Histone H2A.x	14	0	0	14
cytochrome P450 2C19 precursor	9	0	0	9
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	10	0	0	10
Smad3	14	0	0	14
EWS/FLI fusion protein	27	0	0	27
aryl hydrocarbon receptor	25	0	0	25
cytochrome P450 3A4 isoform 1	22	0	0	22
Gamma-aminobutyric acid receptor subunit pi	22	10	3	35
ATP-binding cassette sub-family C member 3	0	45	0	45
Multidrug resistance-associated protein 4	0	46	0	47
Solute carrier family 22 member 6	0	6	0	6
Carbonic anhydrase 12	0	7	1	16
UDP-glucuronosyltransferase 1A9	0	1	0	4
Bile salt export pump	0	11	0	11
Voltage-dependent calcium channel gamma-2 subunit	27	0	0	27
Bile salt export pump	0	66	0	66
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	18	1	31
Carbonic anhydrase 2	0	19	1	32
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	1	1	3
Cytochrome P450 1A2	0	7	1	9
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 3	0	7	1	15
Cytochrome P450 3A4	0	18	0	21
Cytochrome P450 2D6	0	18	1	19
Cytochrome P450 2C9	0	26	0	26
Polyunsaturated fatty acid lipoxygenase ALOX15	0	6	0	6
Gamma-aminobutyric acid receptor subunit beta-1	22	10	3	35
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	22	10	3	35
Gamma-aminobutyric acid receptor subunit gamma-2	22	10	5	37
UDP-glucuronosyltransferase 1-6	0	1	0	2
Glutamate receptor 2	27	2	2	31
Gamma-aminobutyric acid receptor subunit alpha-5	22	10	3	35
Gamma-aminobutyric acid receptor subunit alpha-3	22	10	3	35
Arachidonate 5-lipoxygenase-activating protein	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	3	0	4
Carbonic anhydrase 4	0	13	1	21
Prostaglandin G/H synthase 1	0	3	0	3
Carbonic anhydrase 6	0	8	1	16
Gamma-aminobutyric acid receptor subunit gamma-1	22	10	3	35
Gamma-aminobutyric acid receptor subunit alpha-2	22	10	3	35
Gamma-aminobutyric acid receptor subunit alpha-4	22	10	3	35
Gamma-aminobutyric acid receptor subunit gamma-3	22	10	3	35
Gamma-aminobutyric acid receptor subunit alpha-6	22	10	3	35
Carbonic anhydrase 5A, mitochondrial	0	10	1	19
Prostaglandin G/H synthase 2	0	4	0	5
Carbonic anhydrase 7	0	7	1	15
Nuclear receptor ROR-gamma	8	0	1	9
Cytochrome P450 2J2	0	17	0	17
Gamma-aminobutyric acid receptor subunit alpha-1	22	10	5	37
Gamma-aminobutyric acid receptor subunit beta-3	22	10	3	35
Gamma-aminobutyric acid receptor subunit beta-2	22	10	5	37
Carbonic anhydrase 9	0	10	1	19
GABA theta subunit	22	10	3	35
Canalicular multispecific organic anion transporter 1	0	44	0	44
Carbonic anhydrase 15	0	7	0	12
Carbonic anhydrase 13	0	6	0	13
Gamma-aminobutyric acid receptor subunit epsilon	22	10	3	35
Carbonic anhydrase 14	0	7	1	16
Carbonic anhydrase 5B, mitochondrial	0	7	1	16
toxin B	0	0	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	4	0	4
GALC protein	7	0	0	7
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase	0	2	0	2
arylsulfatase A	26	0	0	26
Carbonic anhydrase	0	2	0	2
Bloom syndrome protein isoform 1	20	0	0	20
thyroid hormone receptor beta isoform a	19	0	0	19
muscleblind-like protein 1 isoform 1	7	0	0	7
Carbonic anhydrase	0	2	0	2
Prolyl endopeptidase	0	2	0	2
Carbonic anhydrase-related protein 11	0	1	0	2
Glycogen phosphorylase, muscle form	0	3	0	3
Renin	0	4	0	4
Carbonic anhydrase 2	0	2	0	2
Cathepsin B	0	1	0	1
Steryl-sulfatase	0	1	0	2
5-hydroxytryptamine receptor 2C	0	11	1	12
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cytochrome P450 2C8	0	4	0	4
Cytochrome P450 2A6	0	3	1	4
5-hydroxytryptamine receptor 2A	0	13	2	15
Androgen receptor	0	8	0	9
Translocator protein	0	3	1	5
Cytochrome P450 2B6	0	2	1	3
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Adenosine receptor A1	0	7	0	12
Serum paraoxonase/arylesterase 1	0	2	0	2
Dipeptidyl peptidase 4	0	0	0	2
Endochitinase	0	1	0	1
Adenosine receptor A2a	0	7	0	14
5-hydroxytryptamine receptor 2B	0	11	1	12
Sodium-dependent serotonin transporter	0	5	1	6
Delta-type opioid receptor	0	6	0	6
Cytochrome P450 2C19	0	8	0	8
Delta-type opioid receptor	0	7	0	7
Mu-type opioid receptor	0	9	1	10
Carbonic anhydrase	0	6	0	10
Kappa-type opioid receptor	0	6	0	6
Carbonic anhydrase	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	2	0	2
Carbonic anhydrase	0	2	0	7
D(2) dopamine receptor	0	10	0	11
Cholinesterase	0	6	0	6
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	5	0	5
Fatty-acid amide hydrolase 1	0	4	0	4
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	9	2	15
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	3	0	3
Carbonic anhydrase	0	2	0	7
Carbonic anhydrase 3	0	2	0	2
Carbonic anhydrase	0	2	0	8
Carbonic anhydrase	0	2	0	8
Carbonic anhydrase	0	3	0	3
Sigma intracellular receptor 2	0	3	0	3
Delta carbonic anhydrase	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	7	2	9
Renin	0	1	0	1
Carbonic anhydrase	0	2	0	7
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	4	1	8
Carbonic anhydrase 4	0	4	0	6
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Chain A, Ferritin light chain	11	0	0	11
DNA topoisomerase 2-alpha	0	0	0	1
Acetylcholinesterase	0	9	0	9
Chain A, Heat Shock Protein 90	0	0	1	1
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, Myosin Ie Heavy Chain	0	0	1	1
Chain A, Preprotein translocase secA	0	0	1	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Phosphoribosylformylglycinamidine synthase	0	1	0	1
Chain A, nucleoside diphosphate kinase A	0	0	1	1
Chain B, nucleoside diphosphate kinase A	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A, Kinesin-like protein KIF11	0	1	0	1
HPr kinase/phosphorylase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
ATP-dependent molecular chaperone HSP82	0	0	0	1
Heat shock protein HSP 90-alpha	0	1	1	3
Heat shock protein HSP 90-beta	0	1	1	3
2-dehydropantoate 2-reductase	0	1	1	2
Heat shock 70 kDa protein 1A	0	1	1	2
Endoplasmic reticulum chaperone BiP	0	0	1	1
Heat shock cognate 71 kDa protein	0	0	1	1
Pyruvate kinase PKM	0	0	0	1
Pyruvate kinase PKLR	0	0	0	1
Endoplasmin	0	0	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
5'-nucleotidase	0	2	0	2
Mu-type opioid receptor	0	13	4	17
Delta-type opioid receptor	0	6	2	8
Kappa-type opioid receptor	0	8	2	10
Endoplasmin	0	1	1	2
P2Y purinoceptor 2	0	0	1	1
Phosphatidylinositol 4-kinase alpha	0	2	0	2
P2X purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 4	0	0	1	1
P2X purinoceptor 5	0	0	1	1
P2X purinoceptor 6	0	0	1	1
P2X purinoceptor 3	0	0	1	1
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
P2Y purinoceptor 6	0	0	1	1
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	2
P2Y purinoceptor 11	0	0	1	1
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	2
P2Y purinoceptor 12	0	0	1	1
Sensor protein kinase WalK	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	2	0	2
P2X purinoceptor 2	0	0	1	1
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	1	0	3
Glutamate receptor ionotropic, NMDA 1	0	9	2	15
Proton-coupled amino acid transporter 1	0	8	0	9
Adenosine deaminase	0	0	0	1
NFKB1 protein, partial	12	0	0	12
D(1A) dopamine receptor	21	0	0	21
atrial natriuretic peptide receptor 2 precursor	8	0	0	8
muscarinic acetylcholine receptor M1	27	0	0	27
Solute carrier family 22 member 1	0	18	0	21
Polyunsaturated fatty acid lipoxygenase ALOX15B	10	0	0	10
Voltage-dependent L-type calcium channel subunit alpha-1F	0	15	0	15
5-hydroxytryptamine receptor 4	0	28	1	29
Albumin	0	0	7	7
High affinity nerve growth factor receptor	0	1	2	3
Aldo-keto reductase family 1 member B1	0	22	0	22
Muscarinic acetylcholine receptor M2	0	19	3	26
Muscarinic acetylcholine receptor M4	0	13	1	17
Muscarinic acetylcholine receptor M1	0	9	2	14
Muscarinic acetylcholine receptor M3	0	8	2	13
Muscarinic acetylcholine receptor M4	0	8	2	13
Muscarinic acetylcholine receptor M5	0	8	2	13
Muscarinic acetylcholine receptor M5	0	17	1	21
Alpha-2A adrenergic receptor	0	21	3	25
Muscarinic acetylcholine receptor M2	0	8	2	14
Muscarinic acetylcholine receptor M1	0	18	4	26
Angiotensin-converting enzyme	0	9	0	9
D(2) dopamine receptor	0	17	2	22
Alpha-2B adrenergic receptor	0	22	1	24
Alpha-2C adrenergic receptor	0	11	3	15
5-hydroxytryptamine receptor 1A	0	21	3	25
Muscarinic acetylcholine receptor M3	0	16	2	21
D(1A) dopamine receptor	0	14	1	17
D(1B) dopamine receptor	0	4	0	6
UDP-glucuronosyltransferase 1A4	0	1	0	4
Sodium-dependent noradrenaline transporter	0	24	2	26
Histamine H2 receptor	0	13	2	15
Alpha-1D adrenergic receptor	0	10	1	12
5-hydroxytryptamine receptor 2A	0	24	1	25
5-hydroxytryptamine receptor 2C	0	29	1	30
5-hydroxytryptamine receptor 1B	0	14	1	15
5-hydroxytryptamine receptor 1D	0	5	1	6
5-hydroxytryptamine receptor 1F	0	5	1	6
5-hydroxytryptamine receptor 6	0	2	1	3
Histamine H1 receptor	0	6	1	7
Sodium-dependent serotonin transporter	0	18	3	21
5-hydroxytryptamine receptor 7	0	4	1	5
5-hydroxytryptamine receptor 5A	0	2	1	3
5-hydroxytryptamine receptor 5B	0	2	1	3
Histamine H1 receptor	0	17	2	19
D(3) dopamine receptor	0	18	2	23
Sodium channel protein type 1 subunit alpha	0	7	0	7
Sodium channel protein type 4 subunit alpha	0	11	0	14
UDP-glucuronosyltransferase 1A3	0	0	0	1
5-hydroxytryptamine receptor 3A	0	4	1	5
5-hydroxytryptamine receptor 2B	0	26	2	28
Alpha-1A adrenergic receptor	0	18	2	20
Histamine H2 receptor	18	2	1	25
5-hydroxytryptamine receptor 6	0	17	1	18
5-hydroxytryptamine receptor 7	0	13	0	13
Voltage-dependent N-type calcium channel subunit alpha-1B	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	6	0	6
Voltage-dependent L-type calcium channel subunit alpha-1D	0	15	0	15
Sodium-dependent dopamine transporter	0	14	2	16
Voltage-dependent L-type calcium channel subunit alpha-1S	0	15	0	15
Voltage-dependent L-type calcium channel subunit alpha-1C	0	20	0	21
Sodium channel protein type 5 subunit alpha	0	16	0	16
Sodium channel protein type 9 subunit alpha	0	15	0	15
5-hydroxytryptamine receptor 4	0	3	1	5
Nuclear receptor subfamily 3 group C member 3	0	8	0	8
Sodium channel protein type 2 subunit alpha	0	8	0	8
Sigma non-opioid intracellular receptor 1	0	20	0	20
5-hydroxytryptamine receptor 3B	0	4	1	5
Sodium channel protein type 3 subunit alpha	0	9	0	9
Sodium channel protein type 11 subunit alpha	0	6	0	6
Sodium channel protein type 8 subunit alpha	0	6	0	6
Histamine H3 receptor	0	5	2	7
Sodium channel protein type 10 subunit alpha	0	7	0	7
interleukin 8	4	0	0	4
phosphopantetheinyl transferase	24	0	0	24
farnesoid X nuclear receptor	24	0	0	24
tumor necrosis factor	2	0	0	2
Aurora kinase B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	9	1	10
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
pregnane X nuclear receptor	45	0	0	45
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	4	0	0	4
short transient receptor potential channel 6 isoform 1	0	0	1	1
Muscarinic acetylcholine receptor M1	0	0	1	2
Muscarinic acetylcholine receptor M4	0	1	0	1
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	1	1	3
activating transcription factor 6	15	0	0	15
histone acetyltransferase KAT2A isoform 1	15	0	0	15
Gamma-aminobutyric acid type B receptor subunit 2	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 2	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 1	0	2	0	2
glp-1 receptor, partial	15	0	0	15
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	13	0	0	13
thyroid stimulating hormone receptor	20	0	0	20
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	6	0	0	6
potassium voltage-gated channel subfamily H member 2 isoform d	25	0	0	25
D(4) dopamine receptor	0	8	1	12
Spike glycoprotein	25	2	3	30
beta-2 adrenergic receptor	4	0	0	4
Beta-2 adrenergic receptor	0	3	3	6
Beta-2 adrenergic receptor	0	3	2	7
pregnane X receptor	10	0	0	10
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	32	0	0	32
nuclear receptor subfamily 1, group I, member 2	8	0	0	8
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	14	3	22
Glycine receptor subunit alpha-1	0	14	0	14
Glycine receptor subunit beta	0	14	0	14
Glycine receptor subunit alpha-2	0	14	0	14
Glycine receptor subunit alpha-3	0	14	0	14
ORF73	0	0	2	2
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	7	0	0	7
nuclear receptor ROR-gamma isoform 1	16	0	0	16
Cholinesterase	0	6	0	6
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	5	3	8
Adenosine receptor A3	0	8	1	9
Replicase polyprotein 1ab	0	7	3	10
Amine oxidase [flavin-containing] A	0	6	0	6
Amine oxidase [flavin-containing] B	0	6	2	8
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	4	0	4
Adenosine receptor A3	0	3	0	3
Adenosine receptor A2a	0	6	4	12
Adenosine receptor A2b	0	2	0	4
Adenosine receptor A2b	0	3	0	5
Adenosine receptor A1	0	7	2	13
Vasopressin V2 receptor	0	0	0	2
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	2	0	2
Adenosine receptor A1	0	3	0	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	2	0	2
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	1	1	4
Chitotriosidase-1	0	2	0	2
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	3
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	3	4
Endochitinase B1	0	2	0	2
Phosphodiesterase	0	1	0	1
Guanine deaminase	0	1	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	9	0	0	9
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
endonuclease IV	9	0	0	9
ClpP	1	0	0	1
electroneutral potassium-chloride cotransporter KCC2	0	0	1	1
Fumarate hydratase	12	0	0	12
TSHR protein	1	0	0	1
apical membrane antigen 1, AMA1	5	0	0	5
nonstructural protein 1	12	0	0	12
polyprotein	12	0	0	12
LacZ protein (plasmid)	0	0	2	2
XBP1	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	5	0	0	5
serine-protein kinase ATM isoform a	1	0	0	1
lysosomal alpha-glucosidase preproprotein	3	0	0	3
hexokinase-4 isoform 1	2	0	0	2
NPC intracellular cholesterol transporter 1 precursor	5	0	0	5
peripheral myelin protein 22 isoform 1	20	0	0	20
type-1 angiotensin II receptor	0	2	0	2
glucokinase regulatory protein	2	0	0	2
apelin receptor	0	2	0	2
heat shock protein HSP 90-alpha isoform 2	0	0	0	3
DNA damage-inducible transcript 3 protein	0	1	0	1
Vpr	4	0	0	4
streptokinase A precursor	0	0	1	1
neuropeptide S receptor isoform A	7	0	0	7
Amyloid-beta precursor protein	2	1	0	3
Alpha-synuclein	4	0	0	4
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
heat shock protein 90, putative	0	0	0	3
PPM1D protein	6	0	0	6
Acetylcholinesterase	0	5	0	5
L-lactate dehydrogenase A chain	0	2	0	2
Interferon beta	27	0	0	27
Cytochrome P450 2C11	0	1	0	1
5-hydroxytryptamine receptor 1A	0	6	1	7
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Fatty acid-binding protein, liver	0	2	0	2
Cytochrome P450 3A5	0	1	0	1
Cannabinoid receptor 1	0	3	1	6
Cytochrome P450 3A7	0	1	0	1
Caspase-1	0	1	1	2
Cannabinoid receptor 2	0	3	2	7
Peroxisome proliferator-activated receptor gamma	0	1	4	5
N-acylethanolamine-hydrolyzing acid amidase	0	1	0	1
Cytochrome P450 1B1	0	2	0	2
Heat sensitive channel TRPV3	0	1	1	2
Sigma intracellular receptor 2	0	2	0	2
Transient receptor potential cation channel subfamily A member 1	0	1	2	3
Transient receptor potential cation channel subfamily V member 1	0	1	1	2
Transient receptor potential cation channel subfamily M member 8	0	1	0	1
Transient receptor potential cation channel subfamily V member 4	0	2	1	3
Transient receptor potential cation channel subfamily V member 2	0	2	1	3
G-protein coupled receptor 55	0	1	2	3
Diacylglycerol lipase-alpha	0	1	0	1
acetylcholinesterase	17	0	0	17
Major prion protein	0	0	3	3
Sodium channel protein type 1 subunit alpha	0	7	0	7
Sodium channel protein type 2 subunit alpha	0	8	0	8
Sodium channel protein type 3 subunit alpha	0	7	0	7
UDP-glucuronosyltransferase 2B7	0	2	0	4
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
ATPase family AAA domain-containing protein 5	18	0	0	18
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	0	5
Gamma-aminobutyric acid receptor subunit beta-1	0	3	0	5
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	0	5
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	0	8	4	12
Gamma-aminobutyric acid receptor subunit gamma-2	0	7	4	11
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	0	5
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	0	5
Gamma-aminobutyric acid receptor subunit beta-3	0	8	3	11
Cholecystokinin receptor type A	0	2	0	2
Gastrin/cholecystokinin type B receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	6	4	10
Gamma-aminobutyric acid receptor subunit alpha-3	0	6	3	9
Gamma-aminobutyric acid receptor subunit alpha-2	0	6	4	10
M-phase phosphoprotein 8	15	0	0	15
Proteasome subunit beta type-11	0	0	0	1
Thrombopoietin	9	0	0	9
caspase 7, apoptosis-related cysteine protease	9	0	0	9
NADPH oxidase 1	0	1	0	1
G	20	0	0	20
Snq2p	0	0	0	1
caspase-3	9	0	0	9
Adenylate cyclase type 1	0	3	0	3
Caspase-7	4	0	0	4
Spike glycoprotein	0	2	3	5
Replicase polyprotein 1ab	0	2	3	5
cellular tumor antigen p53 isoform a	7	0	0	7
caspase-3	4	0	0	4
histone deacetylase 9 isoform 3	4	0	0	4
heat shock protein beta-1	13	0	0	13
Proteasome subunit alpha type-7	0	0	0	1
Transmembrane protease serine 2	0	2	3	5
Glutamate receptor ionotropic, NMDA 2D	0	4	0	4
Transient receptor potential cation channel subfamily V member 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	4	0	4
Epidermal growth factor receptor	0	2	0	2
HLA class I histocompatibility antigen, B alpha chain	20	0	0	20
Albumin	0	3	5	9
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Major prion protein	0	0	1	1
Integrin beta-3	5	0	1	6
Tyrosine-protein kinase Fyn	0	2	0	2
Procathepsin L	0	2	3	5
ATP-dependent translocase ABCB1	0	23	1	37
Integrin alpha-IIb	5	0	1	6
Replicase polyprotein 1a	0	2	3	5
Replicase polyprotein 1ab	0	2	3	5
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	2	1	3
Alpha-1B adrenergic receptor	0	16	2	18
Sphingomyelin phosphodiesterase	0	1	0	1
D	0	5	0	5
D(3) dopamine receptor	0	7	0	7
Alpha-2B adrenergic receptor	0	9	2	11
D(2) dopamine receptor	0	4	0	4
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	4	0	4
Adenylate cyclase type 3	0	3	0	3
Alpha-2C adrenergic receptor	0	9	2	11
Alpha-2A adrenergic receptor	0	9	2	11
Alpha-1D adrenergic receptor	0	12	2	14
Sodium-dependent dopamine transporter	0	5	1	6
D(1B) dopamine receptor	0	5	0	5
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	3	1	4
Adenylate cyclase type 4	0	3	0	3
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
Trypanothione reductase	0	4	0	4
D(4) dopamine receptor	0	5	0	5
Histamine H1 receptor	0	2	3	6
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
5-hydroxytryptamine receptor 7	0	3	1	4
Adenylate cyclase type 8	0	3	0	3
Proteasome subunit beta type-10	0	0	0	1
Melanocortin receptor 3	0	2	0	2
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
Gastrin/cholecystokinin type B receptor	0	2	0	2
Proteasome subunit alpha type-6	0	0	2	3
Calmodulin	0	1	2	3
Aldehyde oxidase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	8	2	14
Glutamate receptor ionotropic, NMDA 2C	0	8	2	14
Adenylate cyclase type 6	0	3	0	3
Adenylate cyclase type 5	0	3	0	3
Glutamate receptor ionotropic, NMDA 1	0	5	0	5
Aldehyde oxidase	0	3	0	3
Glutamate receptor ionotropic, NMDA 2A	0	5	0	5
Glutamate receptor ionotropic, NMDA 2B	0	5	0	5
Glutamate receptor ionotropic, NMDA 2C	0	4	0	4
Glutamate receptor ionotropic, NMDA 2D	0	8	2	14
Adenylyl cyclase 7	0	3	0	3
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	4	0	4
Glutamate receptor ionotropic, NMDA 3B	0	8	2	14
Inositol hexakisphosphate kinase 1	20	0	0	20
D	0	2	0	2
Proteasome subunit beta type-7	0	0	0	1
Angiotensin-converting enzyme 2	0	2	3	5
Glutamate receptor ionotropic, NMDA 3A	0	8	2	14
cytochrome P450 2C9, partial	20	0	0	20
Fatty acid-binding protein, liver	0	3	1	4
Peroxisome proliferator-activated receptor alpha	0	0	1	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Peroxisome proliferator-activated receptor alpha	1	0	1	2
Trypanothione reductase	0	1	0	1
Envelope glycoprotein	0	0	1	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
PAX8	0	0	0	1
nuclear receptor subfamily 0 group B member 1	0	2	0	2
cytochrome P450 2C9 precursor	11	0	0	11
steroidogenic factor 1	0	2	0	2
caspase-1 isoform alpha precursor	2	0	0	2
Solute carrier family 22 member 3	0	3	0	4
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	5
Tubulin beta-4A chain	0	2	2	5
ATP-dependent translocase ABCB1	0	5	0	5
Tubulin beta chain	0	2	2	5
Tubulin alpha-3C chain	0	2	2	5
Serine/threonine-protein kinase pim-1	0	1	0	1
ATP-dependent translocase ABCB1	0	5	0	6
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	2	0	2
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Tubulin beta-1 chain	0	2	2	5
histone-lysine N-methyltransferase 2A isoform 2 precursor	6	0	0	6
relaxin receptor 1 isoform 1	1	0	0	1
relaxin receptor 2 isoform 1	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	5	5
Solute carrier family 2, facilitated glucose transporter member 1	0	0	1	1
Adenylate cyclase type 8	0	0	1	1
Relaxin receptor 1	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
dopamine D1 receptor	4	0	0	4
Sex hormone-binding globulin	0	0	3	3
Corticosteroid-binding globulin	0	4	0	4
Multidrug and toxin extrusion protein 1	0	9	0	9
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Beta-glucuronidase	0	1	0	1
Beta-glucuronidase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	3	0	3
G-protein coupled bile acid receptor 1	0	0	2	2
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
Solute carrier organic anion transporter family member 1A4	0	2	0	6
Solute carrier organic anion transporter family member 1A5	0	0	0	3
Multidrug resistance-associated protein 1	0	2	1	5
Solute carrier organic anion transporter family member 1A1	0	2	0	5
Solute carrier organic anion transporter family member 1A2	0	0	0	3
Solute carrier organic anion transporter family member 1A3	0	0	0	2
ATP-binding cassette sub-family C member 11	0	0	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Solute carrier family 22 member 11	0	1	0	2
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier organic anion transporter family member 1B1	0	7	0	10
Solute carrier family 22 member 3	0	1	0	1
Solute carrier family 22 member 2	0	10	0	11
Phenylethanolamine N-methyltransferase	0	1	0	1
Amine oxidase [flavin-containing] B	0	3	0	3
Amine oxidase [flavin-containing] B	0	1	0	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	1	1	2
Sigma non-opioid intracellular receptor 1	0	5	1	6
Gamma-aminobutyric acid	0	2	1	3
Gamma-aminobutyric acid receptor subunit pi	0	5	0	5
Gamma-aminobutyric acid receptor subunit delta	0	5	0	5
Alpha-1-acid glycoprotein 1	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-1	0	5	2	7
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit delta	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	1	3
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	5	4	9
Gamma-aminobutyric acid receptor subunit alpha-4	0	5	2	7
Gamma-aminobutyric acid receptor subunit beta-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit epsilon	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-6	0	5	2	7
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-1	0	5	0	5
Gamma-aminobutyric acid receptor subunit pi	0	2	1	3
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	1	3
Gamma-aminobutyric acid receptor subunit theta	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit theta	0	5	0	5
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	8	0	8
Voltage-dependent L-type calcium channel subunit alpha-1C	0	7	0	7
Voltage-dependent L-type calcium channel subunit alpha-1D	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1S	0	4	0	4
Histamine N-methyltransferase	0	0	0	1
Solute carrier family 22 member 1	0	10	0	13
Calcium release-activated calcium channel protein 1	0	1	0	1
Protein orai-2	0	1	0	1
Protein orai-3	0	1	0	1
Histamine H4 receptor	0	2	2	4
Histamine H3 receptor	0	1	0	2
Solute carrier family 22 member 2	0	5	0	7
Multidrug and toxin extrusion protein 2	0	3	0	3
15-lipoxygenase, partial	7	0	0	7
hypothetical protein, conserved	3	0	0	3
pyruvate kinase	3	0	0	3
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
thyrotropin-releasing hormone receptor	4	0	0	4
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
runt-related transcription factor 1 isoform AML1b	1	0	0	1
perilipin-5	0	2	0	2
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
perilipin-1	0	2	0	2
core-binding factor subunit beta isoform 2	1	0	0	1
polypyrimidine tract-binding protein 1 isoform a	1	0	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	2	0	2
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase	0	1	0	1
pyruvate kinase PKM isoform b	3	0	0	3
Fatty-acid amide hydrolase 1	0	3	0	3
Transient receptor potential cation channel subfamily A member 1	0	0	2	3
Carbamate kinase	0	1	0	1
Retinal dehydrogenase 1	0	1	0	1
Aldehyde dehydrogenase, mitochondrial	0	1	0	1
Ornithine decarboxylase	3	0	0	3
Fructose-1,6-bisphosphatase 1	0	1	0	1
C-X-C chemokine receptor type 2	0	2	0	2
Mitogen-activated protein kinase 3	0	1	0	1
Protein-lysine 6-oxidase	0	1	0	1
Lysine-specific demethylase 5A	0	1	0	1
C-C chemokine receptor type 2	0	4	0	4
C-C chemokine receptor type 4	0	2	0	2
C-C chemokine receptor type 5	0	2	0	2
Gasdermin-D	0	1	0	1
Lysyl oxidase homolog 3	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	2	0	2
Lysyl oxidase homolog 4	0	1	0	1
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
Monoglyceride lipase	0	3	0	3
Gasdermin-D	0	1	0	1
Histone-lysine N-methyltransferase EHMT1	0	1	0	1
Lysyl oxidase homolog 2	0	1	0	1
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
large T antigen	0	1	0	1
Glutamate receptor 1	0	2	2	4
Glutamate receptor 3	0	2	2	4
Glutamate receptor 4	0	2	2	4
Glycine receptor subunit alpha-1	0	0	2	2
Cannabinoid receptor 1	0	1	0	1
Cannabinoid receptor 2	0	1	1	2
N-arachidonyl glycine receptor	0	0	1	1
Lysophosphatidylserine lipase ABHD12	0	1	0	1
Monoacylglycerol lipase ABHD6	0	1	0	1
Cannabinoid receptor 2	0	2	0	2
Beta-2 adrenergic receptor	0	6	0	7
Beta-3 adrenergic receptor	0	4	1	5
Eyes absent homolog 2	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
Ghrelin O-acyltransferase	0	1	0	1
14 kDa phosphohistidine phosphatase	0	1	0	1
Kappa-type opioid receptor	0	3	0	3
Mu-type opioid receptor	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	4	0	4
Potassium voltage-gated channel subfamily D member 2	0	3	0	3
Sodium-dependent noradrenaline transporter	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Acetylcholinesterase	0	2	0	2
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	3	0	3
Sodium-dependent serotonin transporter	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Transporter	0	2	0	2
Transporter	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Sodium/bile acid cotransporter	0	2	0	2
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	4	0	4
thioredoxin glutathione reductase	5	0	0	5
ubiquitin carboxyl-terminal hydrolase 2 isoform a	4	0	0	4
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	2	2
Histone deacetylase 3	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	3	0	3
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	2	0	2
Sodium- and chloride-dependent GABA transporter 2	0	3	0	3
Sodium- and chloride-dependent GABA transporter 3	0	3	0	3
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	3	0	3
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Histone deacetylase 4	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Histone deacetylase 1	0	2	0	2
Sterol O-acyltransferase 1	0	0	1	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	2	0	2
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Platelet glycoprotein VI	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Excitatory amino acid transporter 4	0	1	0	1
Glutathione reductase, mitochondrial	0	4	0	4
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	1	2	3
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	5
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
ATP-binding cassette sub-family C member 9	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	4
Chymotrypsinogen A	0	2	0	2
ATP synthase subunit beta, mitochondrial	0	1	0	1
ATP synthase subunit delta, mitochondrial	0	1	0	1
ATP synthase subunit gamma, mitochondrial	0	1	0	1
ATP synthase subunit epsilon, mitochondrial	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	1	0	1
Cholesteryl ester transfer protein	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	2	0	2
Solute carrier family 15 member 1	0	1	0	1
ATP-binding cassette sub-family C member 8	0	1	0	1
ATP-sensitive inward rectifier potassium channel 11	0	1	0	1
Solute carrier family 22 member 7	0	2	0	2
Solute carrier family 15 member 2	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	8	0	9
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase	0	1	0	1
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase	0	1	0	1
Glutamine synthetase	0	1	0	1
Cytochrome P450 71B1	0	1	0	2
Glutamine synthetase	0	1	0	1
2-dehydro-3-deoxyphosphooctonate aldolase	0	1	0	1
Purine nucleoside phosphorylase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Shiga toxin subunit A	0	1	0	1
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Cocaine esterase	0	1	0	1
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Integrin alpha-4	0	1	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
Beta-1 adrenergic receptor	0	5	1	7
5-hydroxytryptamine receptor 3A	0	2	0	2
C-8 sterol isomerase	0	2	0	2
5-hydroxytryptamine receptor 2C	0	1	0	1
Alpha-1A adrenergic receptor	0	3	3	7
5-hydroxytryptamine receptor 2A	0	1	0	1
Alpha-1B adrenergic receptor	0	2	2	5
5-hydroxytryptamine receptor 2A	0	1	0	1
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
5-hydroxytryptamine receptor 2B	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	0	2
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Protease	0	2	0	2
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Macrophage migration inhibitory factor	0	2	0	2
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Equilibrative nucleoside transporter 4	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carboxylic ester hydrolase	0	0	0	1
Glycogen synthase kinase-3 alpha	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Protein cereblon	0	6	0	6
Uracil nucleotide/cysteinyl leukotriene receptor	0	2	0	2
Phenol oxidase	0	1	0	1
Endolysin	0	0	1	1
Integrin beta-2	0	1	1	2
Intercellular adhesion molecule 1	0	1	1	2
Trp operon repressor	0	0	1	1
Integrin alpha-L	0	1	2	3
Adenosine kinase	0	0	1	1
Peptide deformylase 1A, chloroplastic/mitochondrial	0	1	0	1
Peptide deformylase	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Potassium voltage-gated channel subfamily E member 1	0	2	0	2
Potassium voltage-gated channel subfamily KQT member 1	0	2	0	2
Sodium channel protein type 10 subunit alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	5	0	5
Intestinal-type alkaline phosphatase	0	4	0	4
Phospholipase A-2-activating protein	0	4	0	4
WRN	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
Polyphenol oxidase 2	0	0	0	1
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosinase	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
SLC16A10 protein	0	0	0	3
Monocarboxylate transporter 10	0	0	0	3
phosphoglycerate kinase	1	0	0	1
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 18	0	1	0	1
Chain A, Antigen Cd11a (p180)	0	1	0	1
PINK1	2	0	0	2
isocitrate dehydrogenase 1, partial	1	0	0	1
bcl-2-related protein A1	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	4	0	4
Neutrophil elastase	0	1	0	1
Insulin receptor	0	3	0	3
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	3	0	3
Lanosterol 14-alpha demethylase	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Acyl-CoA:cholesterol acyltransferase	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
DNA polymerase III, partial	1	0	0	1
tumor susceptibility gene 101 protein	1	0	0	1
5-hydroxytryptamine receptor 3E	0	0	1	1
5-hydroxytryptamine receptor 3B	0	0	1	1
Myeloperoxidase	0	2	0	2
5-hydroxytryptamine receptor 3A	0	0	1	1
Lactoperoxidase	0	1	0	1
5-hydroxytryptamine receptor 3D	0	0	1	1
5-hydroxytryptamine receptor 3C	0	0	1	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Mitogen-activated protein kinase 1	0	1	1	2
Equilibrative nucleoside transporter 1	0	1	0	1
B2 bradykinin receptor	0	1	0	1
Quinolone resistance protein NorA	0	2	0	3
Transient receptor potential cation channel subfamily A member 1	0	0	2	2
eyes absent homolog 2 isoform a	1	0	0	1
Phospholipase A2, membrane associated	0	0	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Platelet-activating factor receptor	0	0	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	2	0	2
Leukotriene B4 receptor 1	0	0	0	1
Myosin light chain kinase, smooth muscle	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Leukotriene B4 receptor 2	0	0	0	1
Chain H, Igg2b-kappa 40-50 Fab (heavy Chain)	0	1	0	1
Chain L, Igg2b-kappa 40-50 Fab (light Chain)	0	1	0	1
Chain A, Na, K-ATPase alpha subunit	0	0	1	1
STAT3, partial	0	1	0	1
Kruppel-like factor 5	0	1	0	1
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	3
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	3
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	2
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	3
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	2
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	2
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	2
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	2
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	2	2	4
Vasopressin V1a receptor	0	1	0	1
Vasopressin V1a receptor	0	3	2	5
Vasopressin V1b receptor	0	1	1	2
Vasopressin V1b receptor	0	1	0	1
Oxytocin receptor	0	1	0	1
Oxytocin receptor	0	0	1	1
Vasopressin V2 receptor	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Alpha-1B adrenergic receptor	0	0	1	1
Beta-1 adrenergic receptor	0	2	2	4
Beta-3 adrenergic receptor	0	2	2	4
POU domain, class 2, transcription factor 1	0	0	0	1
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	0	0	1
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C gamma type	0	1	1	2
Protein kinase C beta type	0	1	1	2
Proto-oncogene vav	0	0	1	1
Protein kinase C alpha type	0	1	1	3
Protein kinase C eta type	0	1	1	2
Protein kinase C delta type	0	1	1	2
Protein kinase C epsilon type	0	1	1	2
Protein kinase C theta type	0	1	1	2
Protein kinase C delta type	0	1	1	2
Transient receptor potential cation channel subfamily V member 4	0	0	1	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Cytochrome P450 2A13	0	1	1	2
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Sodium/potassium/calcium exchanger 4	0	1	1	2
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Sodium/potassium/calcium exchanger 2	0	1	1	2
Solute carrier family 22 member 6	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Solute carrier family 22 member 7	0	1	0	1
luciferase	0	0	0	1
Estrogen receptor	0	4	1	5
Progesterone receptor	0	4	1	6
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	4	1	6
Androgen receptor	0	4	1	5
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	3	1	4
Solute carrier family 22 member 1	0	2	0	2
Sterol O-acyltransferase 1	0	1	0	1
Solute carrier family 22 member 2	0	2	0	2
Acetylcholinesterase	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Solute carrier family 22 member 4	0	1	0	1
DNA (cytosine-5)-methyltransferase 3-like	0	1	0	1
DNA (cytosine-5)-methyltransferase 3A	0	1	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Beta-1 adrenergic receptor	0	1	1	3
Endothelin-1 receptor	0	1	1	2
5-hydroxytryptamine receptor 1B	0	3	1	4
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Pyridoxal kinase	0	0	0	2
Histidine-rich protein PFHRP-II	0	2	0	2
Cytochrome P450 2D1	0	2	0	2
Cytochrome P450 2D26	0	2	0	2
Cytochrome P450 2D3	0	2	0	2
UDP-glucuronosyltransferase 2B10	0	1	0	1
Cytochrome P450 2D4	0	2	0	2
Multidrug resistance protein 1a	0	0	0	1
Voltage-gated sodium channel Nav1.5 cardiac isoform	0	1	0	1
hemoglobin subunit beta	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
DNA topoisomerase 1	0	1	0	1
Chromaffin granule amine transporter	0	1	0	1
Caspase-7	1	0	0	1
Synaptic vesicular amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	2	1	3
Synaptic vesicular amine transporter	0	1	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Dihydrofolate reductase	0	3	0	3
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Amine oxidase [flavin-containing] A	0	2	0	2
Renin	0	1	0	1
Pyruvate kinase PKM	0	0	1	1
Neutral amino acid transporter A	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
photoreceptor-specific nuclear receptor	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Free fatty acid receptor 3	0	0	1	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Chain A, Ribosomal protein S6 kinase alpha-1	0	1	0	1
Chain X, Tyrosine-protein kinase Lyn	0	1	0	1
Chain A, Dual specificity protein kinase TTK	0	0	1	1
Chain A, Dual specificity protein kinase TTK	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Pyridoxal kinase	0	1	0	1
Chain A, Pyridoxal Kinase	0	1	0	1
Phosphodiesterase	0	2	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Adenosine receptor A1	0	2	0	2
Adenosine receptor A1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Stromelysin-1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Substance-P receptor	0	1	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Chain A, Uracil-DNA Glycosylase	0	1	0	1
Chain A, Cytidine Deaminase	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Sodium/nucleoside cotransporter 2	0	2	0	2
Cytidine deaminase	0	1	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Equilibrative nucleoside transporter 1	0	2	0	2
Uridine-cytidine kinase 1	0	0	0	1
Solute carrier family 28 member 3	0	2	0	2
Chain A, Arginase 1	0	1	0	1
Glycoprotein	0	1	0	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Catechol O-methyltransferase	0	1	0	1
Chloroquine resistance transporter	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(3)

Research Excerpts

Overview

Context

Treatment

Research

Studies (435)

Protein Targets (1,358)

Myotonia

Synonyms(3)

Research Excerpts

Overview

Context

Treatment

Research

Studies (435)

Drugs Studied (224)

Protein Targets (1,358)