| Assay ID | Title | Year | Journal | Article |
|---|
| AID1345618 | Human A2A receptor (Adenosine receptors) | 2000 | Molecular pharmacology, May, Volume: 57, Issue:5
| [(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors. |
| AID1345721 | Human A2B receptor (Adenosine receptors) | 2000 | Molecular pharmacology, May, Volume: 57, Issue:5
| [(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors. |
| AID1345822 | Human A3 receptor (Adenosine receptors) | 2005 | Biochemical pharmacology, Nov-25, Volume: 70, Issue:11
| Pharmacological characterization of novel adenosine ligands in recombinant and native human A2B receptors. |
| AID1345721 | Human A2B receptor (Adenosine receptors) | 2005 | Biochemical pharmacology, Nov-25, Volume: 70, Issue:11
| Pharmacological characterization of novel adenosine ligands in recombinant and native human A2B receptors. |
| AID1345618 | Human A2A receptor (Adenosine receptors) | 2006 | Nature reviews. Drug discovery, Mar, Volume: 5, Issue:3
| Adenosine receptors as therapeutic targets. |
| AID1345685 | Human A1 receptor (Adenosine receptors) | 2005 | Biochemical pharmacology, Nov-25, Volume: 70, Issue:11
| Pharmacological characterization of novel adenosine ligands in recombinant and native human A2B receptors. |
| AID1345685 | Human A1 receptor (Adenosine receptors) | 2006 | Nature reviews. Drug discovery, Mar, Volume: 5, Issue:3
| Adenosine receptors as therapeutic targets. |
| AID1345721 | Human A2B receptor (Adenosine receptors) | 2006 | Nature reviews. Drug discovery, Mar, Volume: 5, Issue:3
| Adenosine receptors as therapeutic targets. |
| AID1345618 | Human A2A receptor (Adenosine receptors) | 2005 | Biochemical pharmacology, Nov-25, Volume: 70, Issue:11
| Pharmacological characterization of novel adenosine ligands in recombinant and native human A2B receptors. |
| AID1345822 | Human A3 receptor (Adenosine receptors) | 2000 | Molecular pharmacology, May, Volume: 57, Issue:5
| [(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors. |
| AID1345685 | Human A1 receptor (Adenosine receptors) | 2000 | Molecular pharmacology, May, Volume: 57, Issue:5
| [(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors. |
| AID1345822 | Human A3 receptor (Adenosine receptors) | 2006 | Nature reviews. Drug discovery, Mar, Volume: 5, Issue:3
| Adenosine receptors as therapeutic targets. |
| AID32904 | Displacement of [3H]MRE3008-F20 from human adenosine A3 receptor expressed in CHO cells; range 0.63-0.1.00 | 2000 | Journal of medicinal chemistry, Dec-14, Volume: 43, Issue:25
| Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists: influence of the chain at the N(8) pyrazole nitrogen. |
| AID234472 | Relative binding affinity for human adenosine A2A and A3 receptors | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17
| Fluorosulfonyl- and bis-(beta-chloroethyl)amino-phenylamino functionalized pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives: irreversible antagonists at the human A3 adenosine receptor and molecular modeling studies. |
| AID233967 | Ratio of binding affinity of human A2A receptor to that of human A3 receptor | 2000 | Journal of medicinal chemistry, Dec-14, Volume: 43, Issue:25
| Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists: influence of the chain at the N(8) pyrazole nitrogen. |
| AID33957 | Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 1637-2582 | 2000 | Journal of medicinal chemistry, Dec-14, Volume: 43, Issue:25
| Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists: influence of the chain at the N(8) pyrazole nitrogen. |
| AID1819795 | Binding affinity to mouse adenosine A3 receptor measured by radioligand binding assay | 2022 | ACS medicinal chemistry letters, Apr-14, Volume: 13, Issue:4
| Selective A |
| AID1857156 | Binding affinity to adenosine A3R (unknown origin) | | | |
| AID677723 | Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in CHO cells after 60 mins by scintillation counter | 2012 | Journal of medicinal chemistry, Jun-14, Volume: 55, Issue:11
| Water-soluble pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as human A₃ adenosine receptor antagonists. |
| AID231551 | Ratio of binding affinity for rat adenosine A2A of striatal membranes and human adenosine A3 receptors expressed in HEK293 cells | 1999 | Journal of medicinal chemistry, Nov-04, Volume: 42, Issue:22
| Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists. |
| AID33299 | Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 1637-2582 | 2002 | Journal of medicinal chemistry, Feb-14, Volume: 45, Issue:4
| Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists. |
| AID637482 | Displacement of [3H]-DPCPX from human adenosine A1 receptor expressed in CHO cells | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2
| Pyrrolo- and pyrazolo-[3,4-e][1,2,4]triazolo[1,5-c]pyrimidines as adenosine receptor antagonists. |
| AID637491 | Displacement of [3H]-DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2
| Pyrrolo- and pyrazolo-[3,4-e][1,2,4]triazolo[1,5-c]pyrimidines as adenosine receptor antagonists. |
| AID637484 | Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2
| Pyrrolo- and pyrazolo-[3,4-e][1,2,4]triazolo[1,5-c]pyrimidines as adenosine receptor antagonists. |
| AID677724 | Displacement of [3H]MRE-3008-F20 from human adenosine A3 receptor expressed in CHO cells after 120 mins by scintillation counter | 2012 | Journal of medicinal chemistry, Jun-14, Volume: 55, Issue:11
| Water-soluble pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as human A₃ adenosine receptor antagonists. |
| AID1857155 | Binding affinity to adenosine A3R (unknown origin) assessed as residence time | | | |
| AID1819796 | Binding affinity to human adenosine A3 receptor measured by radioligand binding assay | 2022 | ACS medicinal chemistry letters, Apr-14, Volume: 13, Issue:4
| Selective A |
| AID30462 | Displacement of [3H]DPCPX from human Adenosine A1 receptor expressed in CHO cells | 1999 | Journal of medicinal chemistry, Nov-04, Volume: 42, Issue:22
| Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists. |
| AID1819763 | Binding affinity to rat adenosine A3 receptor measured by radioligand binding assay | 2022 | ACS medicinal chemistry letters, Apr-14, Volume: 13, Issue:4
| Selective A |
| AID32767 | Inhibition of [125I]AB-MECA binding to human Adenosine A3 receptor expressed in HEK cells; Range 0.63-1.00 | 2002 | Journal of medicinal chemistry, Aug-15, Volume: 45, Issue:17
| 1,2,4-Triazolo[5,1-i]purine derivatives as highly potent and selective human adenosine A(3) receptor ligands. |
| AID30454 | Binding affinity against human Adenosine A1 receptor in CHO cells | 2000 | Bioorganic & medicinal chemistry letters, Feb-07, Volume: 10, Issue:3
| Synthesis and preliminary biological evaluation of [3H]-MRE 3008-F20: the first high affinity radioligand antagonist for the human A3 adenosine receptors. |
| AID1857153 | Binding affinity to adenosine A3R (unknown origin) assessed as association constant (kon) | | | |
| AID552780 | Displacement of [3H]MRE3008-F20 from human adenosine A3 receptor expressed in CHO cells after 120 mins | 2011 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 21, Issue:2
| QSAR of adenosine receptor antagonists: Exploring physicochemical requirements for binding of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives with human adenosine A(3) receptor subtype. |
| AID436525 | Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cells | 2009 | Bioorganic & medicinal chemistry, Jul-15, Volume: 17, Issue:14
| Combining selectivity and affinity predictions using an integrated Support Vector Machine (SVM) approach: An alternative tool to discriminate between the human adenosine A(2A) and A(3) receptor pyrazolo-triazolo-pyrimidine antagonists binding sites. |
| AID30778 | Inhibition of [3H]DPCPX binding to human Adenosine A1 receptor expressed in CHO cells; Range 1030-1400 | 2002 | Journal of medicinal chemistry, Aug-15, Volume: 45, Issue:17
| 1,2,4-Triazolo[5,1-i]purine derivatives as highly potent and selective human adenosine A(3) receptor ligands. |
| AID34421 | Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 4.4-6.5 | 2000 | Journal of medicinal chemistry, Dec-14, Volume: 43, Issue:25
| Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists: influence of the chain at the N(8) pyrazole nitrogen. |
| AID34860 | Displacement of [125]AB-MECA from human Adenosine A3 receptor expressed in HEK293 cells | 1999 | Journal of medicinal chemistry, Nov-04, Volume: 42, Issue:22
| Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists. |
| AID1857154 | Binding affinity to adenosine A3R (unknown origin) assessed as dissociation constant (koff) | | | |
| AID32332 | Displacement of [3H]DPCPX from Adenosine A1 receptor of rat brain membranes | 1999 | Journal of medicinal chemistry, Nov-04, Volume: 42, Issue:22
| Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists. |
| AID229663 | Selectivity ratio (h2B/hA3) | 2002 | Journal of medicinal chemistry, Feb-14, Volume: 45, Issue:4
| Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists. |
| AID30909 | Tested for inhibitory activity against human adenosine A1 receptor by displacement of [3H]DPCPX expressed in CHO cells; value ranges from 1027-1396 | 2000 | Journal of medicinal chemistry, Dec-14, Volume: 43, Issue:25
| Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists: influence of the chain at the N(8) pyrazole nitrogen. |
| AID30465 | Displacement of [3H]DPCPX from human Adenosine A1 receptor in CHO cells | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17
| Fluorosulfonyl- and bis-(beta-chloroethyl)amino-phenylamino functionalized pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives: irreversible antagonists at the human A3 adenosine receptor and molecular modeling studies. |
| AID34245 | Binding affinity against human Adenosine A2A receptor in CHO cells | 2000 | Bioorganic & medicinal chemistry letters, Feb-07, Volume: 10, Issue:3
| Synthesis and preliminary biological evaluation of [3H]-MRE 3008-F20: the first high affinity radioligand antagonist for the human A3 adenosine receptors. |
| AID229664 | Selectivity ratio (hA1/hA3) | 2002 | Journal of medicinal chemistry, Feb-14, Volume: 45, Issue:4
| Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists. |
| AID34552 | Perent inhibition of cAMP-accumulation in CHO cells expressing human Adenosine A3 receptor by IB-MECA at 1 uM. | 1999 | Journal of medicinal chemistry, Nov-04, Volume: 42, Issue:22
| Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists. |
| AID238660 | Binding affinity for human adenosine A3 receptor | 2005 | Journal of medicinal chemistry, Jan-13, Volume: 48, Issue:1
| Combined target-based and ligand-based drug design approach as a tool to define a novel 3D-pharmacophore model of human A3 adenosine receptor antagonists: pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as a key study. |
| AID637483 | Displacement of [3H]-SCH 58261 from human adenosine A2A receptor expressed in CHO cells | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2
| Pyrrolo- and pyrazolo-[3,4-e][1,2,4]triazolo[1,5-c]pyrimidines as adenosine receptor antagonists. |
| AID235321 | Selectivity ratio of affinity at hA2A receptor to hA3 receptors | 2002 | Journal of medicinal chemistry, Aug-15, Volume: 45, Issue:17
| 1,2,4-Triazolo[5,1-i]purine derivatives as highly potent and selective human adenosine A(3) receptor ligands. |
| AID33328 | Displacement of [125]AB-MECA from rat Adenosine A3 receptor expressed in CHO cells at 10 mM | 1999 | Journal of medicinal chemistry, Nov-04, Volume: 42, Issue:22
| Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists. |
| AID1451036 | Induction of adipogenesis in human bone marrow-derived mesenchymal stem cells assessed as adiponectin level at 20 to 30 uM measured on day 7 after 48 hrs by ELISA | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Polypharmacology of N |
| AID35055 | Displacement of [3H]MRE3008-F20 from human Adenosine A3 receptor expressed in HEK cells; range 0.63-1.0 | 2002 | Journal of medicinal chemistry, Feb-14, Volume: 45, Issue:4
| Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists. |
| AID436526 | Displacement of [3H]NECA from human adenosine A3 receptor expressed in CHO cells | 2009 | Bioorganic & medicinal chemistry, Jul-15, Volume: 17, Issue:14
| Combining selectivity and affinity predictions using an integrated Support Vector Machine (SVM) approach: An alternative tool to discriminate between the human adenosine A(2A) and A(3) receptor pyrazolo-triazolo-pyrimidine antagonists binding sites. |
| AID34693 | Displacement of [3H]-SCH- 58261 from human adenosine A2A receptor expressed in CHO cells; range 120-155 | 2000 | Journal of medicinal chemistry, Dec-14, Volume: 43, Issue:25
| Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists: influence of the chain at the N(8) pyrazole nitrogen. |
| AID34676 | Inhibition of [3H]CGS-21680 binding to human Adenosine A2A receptor expressed in HEK293 cells; Range 120-155 | 2002 | Journal of medicinal chemistry, Aug-15, Volume: 45, Issue:17
| 1,2,4-Triazolo[5,1-i]purine derivatives as highly potent and selective human adenosine A(3) receptor ligands. |
| AID34366 | Displacement of [3H]SCH-58261 from human Adenosine A2A receptor expressed in CHO cells | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17
| Fluorosulfonyl- and bis-(beta-chloroethyl)amino-phenylamino functionalized pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives: irreversible antagonists at the human A3 adenosine receptor and molecular modeling studies. |
| AID33478 | Inhibition of [3H]DPCPX binding to human Adenosine A2B receptor expressed in HEK cells; Range 1640-2580 | 2002 | Journal of medicinal chemistry, Aug-15, Volume: 45, Issue:17
| 1,2,4-Triazolo[5,1-i]purine derivatives as highly potent and selective human adenosine A(3) receptor ligands. |
| AID34429 | Inhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human Adenosine A3 receptor | 1999 | Journal of medicinal chemistry, Nov-04, Volume: 42, Issue:22
| Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists. |
| AID235322 | Selectivity ratio of affinity at human adenosine A2B and A3 receptors | 2002 | Journal of medicinal chemistry, Aug-15, Volume: 45, Issue:17
| 1,2,4-Triazolo[5,1-i]purine derivatives as highly potent and selective human adenosine A(3) receptor ligands. |
| AID34714 | Binding affinity against human Adenosine A3 receptor in CHO cells | 2000 | Bioorganic & medicinal chemistry letters, Feb-07, Volume: 10, Issue:3
| Synthesis and preliminary biological evaluation of [3H]-MRE 3008-F20: the first high affinity radioligand antagonist for the human A3 adenosine receptors. |
| AID32884 | Displacement of [3H]-SCH- 58261 from Adenosine A2A receptor in rat striatal membranes | 1999 | Journal of medicinal chemistry, Nov-04, Volume: 42, Issue:22
| Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists. |
| AID231534 | Ratio of binding affinity for human adenosine A1 and A3 receptors expressed in HEK293 cells | 1999 | Journal of medicinal chemistry, Nov-04, Volume: 42, Issue:22
| Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists. |
| AID233966 | Ratio of binding affinity of human A1 receptor to that of human A3 receptor | 2000 | Journal of medicinal chemistry, Dec-14, Volume: 43, Issue:25
| Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists: influence of the chain at the N(8) pyrazole nitrogen. |
| AID677725 | Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production | 2012 | Journal of medicinal chemistry, Jun-14, Volume: 55, Issue:11
| Water-soluble pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as human A₃ adenosine receptor antagonists. |
| AID231549 | Ratio of binding affinity for rat adenosine A1 and human adenosine A3 receptors expressed in HEK293 cells | 1999 | Journal of medicinal chemistry, Nov-04, Volume: 42, Issue:22
| Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists. |
| AID31084 | Selectivity ratio for binding affinities of human Adenosine A1 and Adenosine A3 receptors | 2000 | Bioorganic & medicinal chemistry letters, Feb-07, Volume: 10, Issue:3
| Synthesis and preliminary biological evaluation of [3H]-MRE 3008-F20: the first high affinity radioligand antagonist for the human A3 adenosine receptors. |
| AID234473 | Relative binding of human adenosine A2b and A3 receptors | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17
| Fluorosulfonyl- and bis-(beta-chloroethyl)amino-phenylamino functionalized pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives: irreversible antagonists at the human A3 adenosine receptor and molecular modeling studies. |
| AID677722 | Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells after 120 mins by scintillation counter | 2012 | Journal of medicinal chemistry, Jun-14, Volume: 55, Issue:11
| Water-soluble pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as human A₃ adenosine receptor antagonists. |
| AID33294 | Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17
| Fluorosulfonyl- and bis-(beta-chloroethyl)amino-phenylamino functionalized pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives: irreversible antagonists at the human A3 adenosine receptor and molecular modeling studies. |
| AID30764 | Displacement of [3H]DPCPX from human Adenosine A1 receptor expressed in CHO cells; range 1027-1396 | 2002 | Journal of medicinal chemistry, Feb-14, Volume: 45, Issue:4
| Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists. |
| AID231536 | Ratio of binding affinity for human adenosine A2A and A3 receptors expressed in HEK293 cells | 1999 | Journal of medicinal chemistry, Nov-04, Volume: 42, Issue:22
| Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists. |
| AID34249 | Displacement of specific [3H]-SCH- 58261 binding at human Adenosine A2A receptor expressed in HEK293 cells | 1999 | Journal of medicinal chemistry, Nov-04, Volume: 42, Issue:22
| Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists. |
| AID33058 | Selectivity ratio for binding affinities of human Adenosine A2A and Adenosine A3 receptors | 2000 | Bioorganic & medicinal chemistry letters, Feb-07, Volume: 10, Issue:3
| Synthesis and preliminary biological evaluation of [3H]-MRE 3008-F20: the first high affinity radioligand antagonist for the human A3 adenosine receptors. |
| AID229662 | Selectivity ratio (h2A/hA3) | 2002 | Journal of medicinal chemistry, Feb-14, Volume: 45, Issue:4
| Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists. |
| AID233968 | Ratio of binding affinity of human A2B receptor to that of human A3 receptor | 2000 | Journal of medicinal chemistry, Dec-14, Volume: 43, Issue:25
| Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists: influence of the chain at the N(8) pyrazole nitrogen. |
| AID234471 | Relative binding affinity for human adenosine A1 and A3 receptors | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17
| Fluorosulfonyl- and bis-(beta-chloroethyl)amino-phenylamino functionalized pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives: irreversible antagonists at the human A3 adenosine receptor and molecular modeling studies. |
| AID34884 | Displacement of [3H]MRE3008-F20 from human Adenosine A3 receptor expressed in CHO cells | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17
| Fluorosulfonyl- and bis-(beta-chloroethyl)amino-phenylamino functionalized pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives: irreversible antagonists at the human A3 adenosine receptor and molecular modeling studies. |
| AID268110 | Displacement of [3H]MRE 3008F20 from human adenosine A3 receptor expressed in CHO cells | 2006 | Journal of medicinal chemistry, Jul-13, Volume: 49, Issue:14
| Pharmacophore based receptor modeling: the case of adenosine A3 receptor antagonists. An approach to the optimization of protein models. |
| AID33188 | Percent reversal of 100 nM IB-MECA-inhibited cAMP accumulation in CHO cells expressing human adenosine A3 receptor at 1 uM; range 79-106 | 2000 | Journal of medicinal chemistry, Dec-14, Volume: 43, Issue:25
| Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists: influence of the chain at the N(8) pyrazole nitrogen. |
| AID34526 | Displacement of [3H]SCH-58261 from human Adenosine A2A receptor expressed in HEK293 cells; range 120-155 | 2002 | Journal of medicinal chemistry, Feb-14, Volume: 45, Issue:4
| Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists. |
| AID235320 | Selectivity ratio of affinity at human adenosine A1 and A3 receptors | 2002 | Journal of medicinal chemistry, Aug-15, Volume: 45, Issue:17
| 1,2,4-Triazolo[5,1-i]purine derivatives as highly potent and selective human adenosine A(3) receptor ligands. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1345822 | Human A3 receptor (Adenosine receptors) | 2000 | Bioorganic & medicinal chemistry letters, Feb-07, Volume: 10, Issue:3
| Synthesis and preliminary biological evaluation of [3H]-MRE 3008-F20: the first high affinity radioligand antagonist for the human A3 adenosine receptors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |