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proherbicide

A compound that, on administration, must undergo chemical conversion by biochemical (enzymatic), chemical (possibly following an enzymatic step), or physical (e.g. photochemical) activation processes before becoming the pharmacologically active herbicide for which it is a proherbicide.

ChEBI ID: 136646

Members (6)

MemberDefinitionClass
carfentrazone-ethylAn ethyl ester resulting from the formal condensation of the carboxy group of 2-chloro-3-{2-chloro-5-[4-(difluoromethyl)-3-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-4-fluorophenyl}propanoic acid with ethanol.ethyl 2-chloro-3-{2-chloro-5-[4-(difluoromethyl)-3-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-4-fluorophenyl}propanoate
chlorimuron ethylAn ethyl ester resulting from the formal condensation of the carboxy group of chlorimuron with ethanol. A proherbicide for chloimuron, it is used as herbicide for the control of broad-leaved weeds in peanuts, soya beans, and other crops.chlorimuron-ethyl
haloxyfop-P-methylA methyl 2-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoate that has R configuration. It is a proherbicide (by hydrolysis of the methyl ester) for the herbicide haloxyfop-P, the most active enantiomer of the racemic herbicide haloxyfop.haloxyfop-P-methyl
isoxaflutoleA member of the class of isoxazoles that is 1,2-oxazole substituted by a 2-(methanesulfonyl)-4-(trifluoromethyl)benzoyl group and a cyclopropyl group at positions 4 and 5, respectively. It is a 4-hydroxyphenylpyruvate dioxygenase inhibitor which is used as a herbicide for weed control in maize and sugarcane.isoxaflutole
pinoxadenA pyrazolooxadiazepine that is 7-oxo-1,2,4,5-tetrahydro-7H-pyrazolo[1,2-d][1,4,5]oxadiazepin which is substituted at positions 8 and 9 by 2,6-diethyl-4-methylphenyl and pivaloyloxy groups, respectively. A pro-herbicide (by hydrolysis of the pivalate ester to give the corresponding enol), it is used for control of grass weeds in cereal crops.pinoxaden
triflusulfuron-methylA methyl ester resulting from the formal condensation of the carboxy group of triflusulfuron with methanol. A proherbicide for triflusulfuron.triflusulfuron-methyl

Research

Studies (154)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (0.65)18.2507
2000's63 (40.91)29.6817
2010's68 (44.16)24.3611
2020's22 (14.29)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (0.63%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other159 (99.38%)84.16%

Protein Targets (19)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
acetylcholinesteraseHomo sapiens (human)Potency49.417622
AR proteinHomo sapiens (human)Potency24.578044
Cellular tumor antigen p53Homo sapiens (human)Potency29.747522
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency65.720812
estrogen nuclear receptor alphaHomo sapiens (human)Potency34.376211
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency5.847223
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency3.981111
Histone H2A.xCricetulus griseus (Chinese hamster)Potency35.735111
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency47.467823
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency45.664823
pregnane X nuclear receptorHomo sapiens (human)Potency70.794612
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency53.997124
SMAD family member 2Homo sapiens (human)Potency43.641211
SMAD family member 3Homo sapiens (human)Potency43.641211
thyroid stimulating hormone receptorHomo sapiens (human)Potency54.482722
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency35.810822
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency0.002811

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Acetolactate synthase catalytic subunit, mitochondrialSaccharomyces cerevisiae S288CKi0.003311
Acetolactate synthase, chloroplasticArabidopsis thaliana (thale cress)Ki0.009422