Page last updated: 2024-12-08

ribothymidine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

ribothymidine : A methyluridine having a single methyl substituent at the 5-position on the uracil ring. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID445408
CHEMBL ID106175
CHEBI ID45996
CHEBI ID30821
SCHEMBL ID29298
MeSH IDM0053659

Synonyms (67)

Synonym
ribosylthymine
1-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
1-[(4s,2r,3r,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,3-dihydropyrimidine-2,4-dione
5-methyluridine ,
beta-d-ribofuranoside
1-((2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1h,3h)-dione
5-methyluridine, powder
5-methyluridine, 97%
5MU-5MU-5MU ,
1-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
1463-10-1
CHEMBL106175
chebi:45996 ,
ribothymidine
BMSE000759
M1405
A808481
1-((2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1h,3h)-dione
einecs 215-973-9
thymine riboside
zs1409014a ,
unii-zs1409014a
uridine, 5-methyl-
EPITOPE ID:141497
ribosylthymidine
1-(beta-d-ribofuranosyl)thymine
chebi:30821
AKOS015896830
S6156
AM83947
SCHEMBL29298
38t ,
J-700101
thymine riboside [mi]
thymine riboside, (-)-
pyrimidinedione, 5-methyl-1-.beta.-d-ribofuranosyl-
1-.beta.-d-ribofuranosylthymine 2,4(1h,3h)-pyrimidinedione, 5-methyl-1-.beta.-d-ribofuranosyl-
.beta.-d-ribofuranoside, thymine-1
2,4(1h,3h)-pyrimidinedione, 5-methyl-1-.beta.-d-ribofuranosyl-
1-.beta.-d-ribofuranosylthymine
.beta.-d-ribofuranosylthymine
thymine ribofuranoside
5-methyl-uridine
mfcd00006535
DTXSID20163348
1-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
AC-8172
1-((2r,3r,4s,5r)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-methylpyrimidine-2,4(1h,3h)-dione
1-beta-delta-ribofuranosylthymine
beta-delta-ribofuranoside
5-methyl-1-beta-d-ribofuranosyl-2,4(1h,3h)-pyrimidinedione
thymine-1 beta-d-ribofuranosylthymine
5-methyl-1-beta-delta-ribofuranosyl-2,4(1h,3h)-pyrimidinedione
thymine ribonucleoside
beta-delta-ribofuranoside thymine-1
1-b-d-ribofuranosylthymine
thymine-1 beta-delta-ribofuranosylthymine
b-d-ribofuranoside thymine-1
HY-W009444
CS-W010160
STL507242
DS-18476
Q425078
EN300-2009864
PD099507
Z3037473449
BP-58644
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (3)

RoleDescription
antigenAny substance that stimulates an immune response in the body, such as through antibody production or by presentation to a T-cell receptor after binding to a major histocompability complex (MHC).
human metaboliteAny mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
Escherichia coli metaboliteAny bacterial metabolite produced during a metabolic reaction in Escherichia coli.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
methyluridineA uridine bearing one or more methyl substituents.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (19)

Assay IDTitleYearJournalArticle
AID156691Antiviral activity was measured against vaccinia virus in rabbit kidney cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID718193Competitive inhibition of bovine pancreatic RNase A type 12-A assessed as degradation of yeast tRNA preincubated for 10 mins before addition of the enzyme by double reciprocal plot analysis2012Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24
Triazole pyrimidine nucleosides as inhibitors of Ribonuclease A. Synthesis, biochemical, and structural evaluation.
AID218031Antiviral activity was measured against Reo virus-1 in african green monkey kidney (Vero B) cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID218431Antiviral activity was measured against Rhino virus-9 in human diploid (WI-38) cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID156692Antiviral activity was measured against vesicular stomatitis virus in rabbit kidney cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID87136Antiviral activity was measured against vesicular stomatitis virus in HeLa cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID87135Antiviral activity was measured against polio virus-1 in HeLa cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID216436Concentration required for microscopically detectable alteration of the normal cell morphology in Wi-38 cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID156688Antiviral activity was measured against Herpes simplex virus (HSV-2 G) in rabbit kidney cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID218030Antiviral activity was measured against Parainfluenza virus-3 in african green monkey kidney (Vero B) cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID156696Concentration required for microscopically detectable alteration of the normal cell morphology in PRK cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID218032Antiviral activity was measured against forest virus in african green monkey kidney (Vero B) cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID218171Antiviral activity was measured against Coxsackie virus B4 in african green monkey kidney (Vero B) cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID87131Antiviral activity was measured against Coxsackie virus B4 in HeLa cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID156687Antiviral activity was measured against Herpes simplex virus (HSV-1 KOS) in rabbit kidney cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID87139Concentration required for microscopically detectable alteration of the normal cell morphology in HeLa cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID218430Antiviral activity was measured against Rhino virus-1A in human diploid (WI-38) cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID218035Concentration required for microscopically detectable alteration of the normal cell morphology in Vero B cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID218033Antiviral activity was measured against Sindbis virus in african green monkey kidney (Vero B) cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (79)

TimeframeStudies, This Drug (%)All Drugs %
pre-199027 (34.18)18.7374
1990's9 (11.39)18.2507
2000's10 (12.66)29.6817
2010's24 (30.38)24.3611
2020's9 (11.39)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 31.38

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index31.38 (24.57)
Research Supply Index4.41 (2.92)
Research Growth Index4.74 (4.65)
Search Engine Demand Index42.09 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (31.38)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews4 (4.94%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other77 (95.06%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]