Response Evaluation Criteria in Solid Tumors

An internationally recognized set of published rules used for evaluation of cancer treatment that define when tumors found in cancer patients improve, worsen, or remain stable during treatment. These criteria are based specifically on the response of the tumor(s) to treatment, and not on the overall health status of the patient resulting from treatment.

Synonym
Response Evaluation Criteria in Solid Tumors

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	264 (66.50)	28.8240
2020's	133 (33.50)	9.53

Drug	Relationship Strength	Studies	Trials
dalteparin	medium	1	1
iodine	low	3	0
melatonin	medium	1	1
niacinamide	medium	14	2
selenious acid	medium	1	1
thymine	low	1	0
uracil	low	1	0
1-anilino-8-naphthalenesulfonate	medium	2	2
anastrozole	medium	2	1
fluorouracil	medium	37	11
gossypol	medium	1	1
ifosfamide	medium	3	1
iodixanol	low	2	0
iohexol	low	4	0
iopromide	low	2	0
letrozole	medium	4	3
metformin	medium	2	2
oxonic acid	medium	5	2
pantoprazole	medium	1	1
propranolol	medium	1	1
vorinostat	medium	1	1
tegafur	medium	5	2
temozolomide	low	1	0
thalidomide	medium	1	1
mitomycin	medium	2	2
prednisone	low	1	0
dehydroepiandrosterone	medium	1	1
alanine	medium	1	1
serine	medium	1	1
carbostyril	medium	1	1
trifluridine	low	1	0
valine	medium	1	1
4-butyrolactone	medium	1	1
pyrroles	medium	10	1
quinazolines	medium	11	7
indazoles	medium	19	8
pyrazines	medium	1	1
alpha-aminopyridine	medium	8	7
azomycin	medium	1	1
diphenylamine	low	1	0
deoxycytidine	medium	22	6
lutetium	low	3	0
platinum	medium	4	3
gadolinium	low	1	0
camptothecin	medium	17	8
paclitaxel	medium	23	14
etoposide	medium	3	1
epirubicin	low	6	0
pravastatin	medium	1	1
topotecan	medium	4	2
gemcitabine	medium	22	6
temoporfin	low	1	0
irinotecan	medium	22	7
3-iodobenzylguanidine	low	2	0
capecitabine	medium	14	9
triazoles	medium	2	1
fluorodeoxyglucose f18	medium	46	4
zoledronic acid	low	1	0
fibrinogen	low	1	0
glycidyl nitrate	medium	1	1
fulvestrant	medium	5	5
yttrium radioisotopes	low	16	0
ecteinascidin 743	medium	3	1
1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid	low	1	0
imatinib mesylate	medium	2	2
gefitinib	medium	8	2
methotrexate	low	3	0
docetaxel anhydrous	medium	14	6
erlotinib hydrochloride	medium	11	5
lapatinib	medium	3	3
sorafenib	medium	23	9
lenalidomide	medium	1	1
gossypol acetic acid	medium	1	1
carboplatin	medium	18	13
tretinoin	medium	1	1
epothilone a	medium	1	1
melphalan	low	1	0
s 1033	medium	1	1
tamoxifen	medium	4	2
amrubicin	low	1	0
bilirubin	low	3	0
maytansine	medium	5	4
sirolimus	medium	7	2
su 11248	medium	12	2
palbociclib	medium	1	1
selenium	medium	1	1
everolimus	medium	7	6
ixabepilone	medium	1	1
axitinib	medium	4	3
ac 7700	medium	1	1
taxane	medium	3	1
lenvatinib	medium	8	3
px-866	medium	1	1
cabazitaxel	medium	4	4
hki 272	medium	2	2
rucaparib	medium	2	1
cediranib	medium	1	1
pasireotide	medium	2	2
g(m1) ganglioside	low	1	0
ly-2157299	medium	1	1
pazopanib	medium	16	7
bibw 2992	medium	3	1
binimetinib	medium	1	1
saracatinib	medium	1	1
vinflunine	medium	1	1
regorafenib	medium	9	5
brivanib	medium	1	1
er-086526	medium	2	1
pf 00299804	medium	2	2
crizotinib	medium	6	4
trametinib	low	2	0
veliparib	medium	2	2
th 302	medium	1	1
cysteinyldopa	low	1	0
jaw	low	2	0
n-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide	low	1	0
gastrins	low	1	0
glucagon	low	1	0
oligonucleotides	medium	1	1
buparlisib	medium	4	4
olaparib	medium	4	4
mln 8237	medium	3	3
lde225	medium	1	1
gdc 0449	medium	2	1
cabozantinib	medium	2	2
defactinib	medium	1	1
entrectinib	low	1	0
pexidartinib	low	1	0
azd2014	medium	1	1
plx4032	medium	3	1
piperidines	medium	3	3
interleukin-8	medium	3	2
dabrafenib	low	3	0
ribociclib	medium	1	1
apatinib	medium	6	3
abemaciclib	medium	1	1
pf 3084014	medium	1	1
alectinib	medium	3	3
vasoactive intestinal peptide	low	1	0
sar405838	medium	1	1
s 1 (combination)	medium	5	2
epidermal growth factor	medium	1	1
transforming growth factor beta	low	1	0
pm 01183	medium	1	1
ceritinib	medium	2	2
osimertinib	medium	3	2
pf-06463922	medium	1	1
cyclin d1	low	1	0
orabase	medium	1	1
lutetium lu 177 dotatate	low	3	0
exudates	low	1	0
levoleucovorin	medium	25	8
guanine	medium	1	1
dacarbazine	low	1	0
pemetrexed	medium	5	1
nintedanib	medium	6	6
bmn 673	medium	1	1
pyrimidinones	low	2	0

Protein Targets (1,484)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	2	0	0	2
thioredoxin reductase	15	0	0	15
USP1 protein, partial	13	0	0	13
TDP1 protein	31	0	0	31
vitamin D3 receptor isoform VDRA	12	0	0	12
importin subunit beta-1 isoform 1	4	0	0	4
flap endonuclease 1	4	0	0	4
serine/threonine-protein kinase PLK1	1	0	0	1
snurportin-1	4	0	0	4
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	10	0	0	10
urokinase-type plasminogen activator precursor	6	0	0	6
plasminogen precursor	6	0	0	6
urokinase plasminogen activator surface receptor precursor	6	0	0	6
geminin	27	0	0	27
DNA polymerase kappa isoform 1	10	0	0	10
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	13	14
Beta-lactamase	0	2	0	2
Transthyretin	0	0	1	1
Fatty acid-binding protein, intestinal	0	1	1	2
Fatty acid-binding protein, adipocyte	0	1	1	2
Cyclin-A2	0	8	0	8
Cannabinoid receptor 1	0	1	1	2
Cyclin-dependent kinase 2	0	15	40	55
Choline O-acetyltransferase	0	1	0	1
Mitogen-activated protein kinase 12	0	1	13	14
Guanine nucleotide-binding protein G	1	0	0	1
Fatty acid-binding protein 5	0	0	1	1
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	1	38	39
Mitogen-activated protein kinase 14	0	5	39	44
ATAD5 protein, partial	11	0	0	11
apical membrane antigen 1, AMA1	2	0	0	2
euchromatic histone-lysine N-methyltransferase 2	16	0	0	16
chromobox protein homolog 1	13	0	0	13
lethal factor (plasmid)	5	0	1	6
botulinum neurotoxin type A	0	0	1	1
botulinum neurotoxin type F, BoNT/F	0	0	1	1
dopamine D1 receptor	2	0	0	2
GLS protein	6	0	0	6
Thrombopoietin	3	0	0	3
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
cytochrome P450 2D6 isoform 1	4	0	0	4
cytochrome P450 2C19 precursor	4	0	0	4
ras-related protein Rab-9A	5	0	0	5
histone acetyltransferase KAT2A isoform 1	11	0	0	11
POU domain, class 2, transcription factor 1	0	0	0	1
Spike glycoprotein	32	0	3	35
ATP-dependent phosphofructokinase	10	0	0	10
RAR-related orphan receptor gamma	27	0	0	27
nuclear receptor subfamily 1, group I, member 3	25	0	0	25
retinoid X nuclear receptor alpha	22	0	0	22
estrogen-related nuclear receptor alpha	31	0	0	31
pregnane X nuclear receptor	24	0	0	24
peroxisome proliferator-activated receptor delta	17	0	0	17
PPM1D protein	39	0	0	39
cytochrome P450 family 3 subfamily A polypeptide 4	38	0	0	38
cytochrome P450 2D6	24	0	0	24
Bone morphogenetic protein receptor type-1B	0	0	38	38
Cell division cycle 7-related protein kinase	0	1	25	26
Serine/threonine-protein kinase PLK4	0	4	38	42
ATP-dependent RNA helicase DDX3X	0	0	38	38
Pyridoxal kinase	0	0	38	38
Citron Rho-interacting kinase	0	0	38	38
Serine/threonine-protein kinase Chk1	0	3	39	42
Aurora kinase A	0	6	38	44
Cyclin-G-associated kinase	0	2	38	40
Ephrin type-B receptor 6	0	0	37	37
Peroxisomal acyl-coenzyme A oxidase 3	0	0	38	38
Receptor-interacting serine/threonine-protein kinase 2	0	3	38	41
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	36	36
Dynamin-like 120 kDa protein, mitochondrial	0	0	38	38
Cyclin-T1	0	5	0	5
Eukaryotic translation initiation factor 5B	0	0	23	23
Rho-associated protein kinase 2	0	1	38	39
Serine/threonine-protein kinase ULK1	0	0	38	38
Serine/threonine-protein kinase/endoribonuclease IRE1	0	1	38	39
Ribosomal protein S6 kinase alpha-5	0	0	38	38
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	38	38
Ribosomal protein S6 kinase alpha-4	0	0	38	38
Serine/threonine-protein kinase 16	0	0	38	38
Cyclin-K	0	2	0	2
Cyclin-dependent kinase-like 5	0	0	28	28
Serine/threonine-protein kinase 10	0	0	38	38
Serine/threonine-protein kinase D3	0	1	38	39
Structural maintenance of chromosomes protein 2	0	0	38	38
Mitogen-activated protein kinase kinase kinase 6	0	0	38	38
Mitogen-activated protein kinase kinase kinase kinase 4	0	1	38	39
Serine/threonine-protein kinase LATS1	0	0	38	38
Serine/threonine-protein kinase PAK 4	0	3	38	41
Tyrosine-protein kinase ABL1	0	21	41	63
Epidermal growth factor receptor	0	29	44	74
Interferon beta	51	0	0	51
High affinity nerve growth factor receptor	0	7	35	42
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	33	33
ADP/ATP translocase 2	0	0	38	38
Protein kinase C beta type	0	2	38	40
Insulin receptor	0	11	38	49
Tyrosine-protein kinase Lck	0	13	38	51
Tyrosine-protein kinase Fyn	0	5	38	43
Cyclin-dependent kinase 1	0	8	38	46
Glycogen phosphorylase, liver form	0	0	38	38
Tyrosine-protein kinase Fes/Fps	0	2	38	40
Tyrosine-protein kinase Yes	0	1	38	39
Tyrosine-protein kinase Lyn	0	4	38	42
Proto-oncogene tyrosine-protein kinase receptor Ret	0	14	38	52
Insulin-like growth factor 1 receptor	0	10	38	48
Signal recognition particle receptor subunit alpha	0	0	34	34
Cytochrome c1, heme protein, mitochondrial	0	0	38	38
Hepatocyte growth factor receptor	0	10	36	47
Tyrosine-protein kinase HCK	0	4	38	42
Platelet-derived growth factor receptor beta	0	19	38	57
Replicase polyprotein 1ab	0	3	3	6
Serine/threonine-protein kinase A-Raf	0	3	37	40
Glycogen phosphorylase, brain form	0	0	38	38
Breakpoint cluster region protein	0	4	40	45
Serine/threonine-protein kinase pim-1	0	2	38	40
Fibroblast growth factor receptor 1	0	15	38	54
DNA topoisomerase 2-alpha	0	3	33	41
Cyclin-dependent kinase 4	0	9	38	48
ADP/ATP translocase 3	0	0	38	38
Inosine-5'-monophosphate dehydrogenase 2	0	0	32	32
Proto-oncogene tyrosine-protein kinase Src	0	14	38	52
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	37	37
G2/mitotic-specific cyclin-B1	0	7	0	7
Serine/threonine-protein kinase B-raf	0	7	41	50
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	38	38
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	3	38	41
Tyrosine-protein kinase Fer	0	2	38	40
Protein kinase C alpha type	0	2	38	40
cAMP-dependent protein kinase catalytic subunit alpha	0	2	38	40
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	38	38
Casein kinase II subunit alpha'	0	1	38	39
Ras-related protein Rab-6A	0	0	36	36
Ephrin type-A receptor 1	0	0	34	34
Multifunctional protein ADE2	0	0	38	38
cAMP-dependent protein kinase catalytic subunit gamma	0	1	32	33
cAMP-dependent protein kinase catalytic subunit beta	0	1	38	39
Ferrochelatase, mitochondrial	0	0	39	39
Ribosomal protein S6 kinase beta-1	0	1	37	38
Tyrosine-protein kinase JAK1	0	3	38	41
G1/S-specific cyclin-D1	0	6	0	6
G1/S-specific cyclin-E1	0	5	0	5
Beta-adrenergic receptor kinase 1	0	0	38	38
Probable ATP-dependent RNA helicase DDX6	0	0	37	37
Mitogen-activated protein kinase 3	0	1	38	39
MAP/microtubule affinity-regulating kinase 3	0	0	38	38
Deoxycytidine kinase	0	0	38	40
Mitogen-activated protein kinase 1	0	3	38	41
Ephrin type-A receptor 2	0	4	38	42
Ephrin type-B receptor 2	0	1	38	39
Non-receptor tyrosine-protein kinase TYK2	0	2	38	40
G1/S-specific cyclin-D3	0	5	0	5
Wee1-like protein kinase	0	0	38	38
Heme oxygenase 2	0	0	37	37
S-adenosylmethionine synthase isoform type-2	0	0	35	35
DnaJ homolog subfamily A member 1	0	0	38	38
RAC-alpha serine/threonine-protein kinase	0	3	38	41
RAC-beta serine/threonine-protein kinase	0	1	38	39
Dual specificity protein kinase TTK	0	1	31	32
DNA replication licensing factor MCM4	0	0	37	37
Dual specificity mitogen-activated protein kinase kinase 2	0	4	38	42
Receptor-type tyrosine-protein kinase FLT3	0	13	38	52
Bone morphogenetic protein receptor type-1A	0	0	38	38
Activin receptor type-1B	0	1	38	39
TGF-beta receptor type-1	0	2	38	40
TGF-beta receptor type-2	0	1	36	37
Tyrosine-protein kinase CSK	0	1	38	39
Glycine--tRNA ligase	0	0	38	38
Protein kinase C iota type	0	1	38	39
Exosome RNA helicase MTR4	0	0	38	38
Tyrosine-protein kinase Tec	0	0	38	38
Tyrosine-protein kinase ABL2	0	1	38	39
Tyrosine-protein kinase FRK	0	2	38	40
Tyrosine-protein kinase SYK	0	2	38	40
26S proteasome regulatory subunit 6B	0	0	38	38
Mitogen-activated protein kinase 8	0	1	38	39
Mitogen-activated protein kinase 9	0	1	38	39
Dual specificity mitogen-activated protein kinase kinase 3	0	0	38	38
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	36	36
Casein kinase I isoform alpha	0	3	38	41
Casein kinase I isoform delta	0	0	38	38
MAP kinase-activated protein kinase 2	0	1	38	39
Elongation factor Tu, mitochondrial	0	0	38	38
Choline-phosphate cytidylyltransferase A	0	0	18	18
Casein kinase I isoform epsilon	0	0	38	38
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	38	38
Dual specificity protein kinase CLK1	0	1	37	38
Dual specificity protein kinase CLK3	0	0	28	28
Glycogen synthase kinase-3 alpha	0	0	38	38
Glycogen synthase kinase-3 beta	0	5	38	43
Cyclin-dependent kinase 7	0	6	38	44
Cyclin-dependent kinase 9	0	5	38	43
Ras-related protein Rab-27A	0	0	37	37
Interleukin-1 receptor-associated kinase 1	0	0	38	38
Ribosomal protein S6 kinase alpha-3	0	1	38	39
Cyclin-H	0	5	0	5
CDK-activating kinase assembly factor MAT1	0	4	0	4
Serine/threonine-protein kinase Nek2	0	2	38	40
Serine/threonine-protein kinase Nek3	0	0	38	38
Dual specificity mitogen-activated protein kinase kinase 6	0	0	38	38
LIM domain kinase 1	0	0	38	38
LIM domain kinase 2	0	0	38	38
Tyrosine--tRNA ligase, cytoplasmic	0	0	36	36
5'-AMP-activated protein kinase subunit gamma-1	0	0	38	38
Ephrin type-B receptor 3	0	0	38	38
Ephrin type-A receptor 5	0	0	38	38
Ephrin type-B receptor 4	0	4	38	42
Ephrin type-A receptor 4	0	0	38	38
Adenylate kinase 2, mitochondrial	0	0	37	37
Adenosine kinase	0	0	37	37
Ras-related protein Rab-10	0	0	37	37
Actin-related protein 3	0	0	37	37
Actin-related protein 2	0	0	36	36
GTP-binding nuclear protein Ran	0	0	38	38
Casein kinase I isoform gamma-2	0	0	35	35
Cyclin-dependent kinase 6	0	7	37	45
Cyclin-dependent-like kinase 5	0	3	38	41
Cyclin-dependent kinase 16	0	0	38	38
Cyclin-dependent kinase 17	0	0	36	36
ATP-dependent 6-phosphofructokinase, platelet type	0	0	34	34
Dual specificity mitogen-activated protein kinase kinase 1	0	5	38	43
DNA topoisomerase 2-beta	0	2	39	48
Protein kinase C theta type	0	1	36	37
Activin receptor type-1	0	0	38	38
Macrophage-stimulating protein receptor	0	2	38	40
Focal adhesion kinase 1	0	5	38	43
Protein kinase C zeta type	0	1	21	22
Protein kinase C delta type	0	1	38	39
Tyrosine-protein kinase BTK	0	2	38	40
Activated CDC42 kinase 1	0	3	38	41
Epithelial discoidin domain-containing receptor 1	0	2	38	40
Potassium voltage-gated channel subfamily H member 2	0	19	0	19
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	38	38
Serine/threonine-protein kinase 4	0	0	38	38
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	1	38	39
Dual specificity mitogen-activated protein kinase kinase 5	0	0	38	38
Mitogen-activated protein kinase 7	0	0	37	37
Serine/threonine-protein kinase PAK 2	0	1	34	35
Serine/threonine-protein kinase 3	0	0	38	38
Mitogen-activated protein kinase kinase kinase 1	0	0	38	38
Rho-associated protein kinase 1	0	0	38	38
Non-receptor tyrosine-protein kinase TNK1	0	0	38	38
Serine/threonine-protein kinase ATR	0	0	17	17
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	38	38
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	38	38
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	38	39
Activin receptor type-2B	0	0	38	38
Bone morphogenetic protein receptor type-2	0	0	38	38
Protein-tyrosine kinase 6	0	1	38	39
cGMP-dependent protein kinase 1	0	0	38	38
Cyclin-dependent kinase 13	0	0	38	38
Calcium/calmodulin-dependent protein kinase type 1	0	1	13	14
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	38	38
Protein-tyrosine kinase 2-beta	0	3	38	41
Maternal embryonic leucine zipper kinase	0	3	38	41
Structural maintenance of chromosomes protein 1A	0	0	34	34
Chromodomain-helicase-DNA-binding protein 4	0	0	35	35
Cyclin-dependent kinase 5 activator 1	0	3	0	3
Delta(24)-sterol reductase	0	0	38	38
Ribosomal protein S6 kinase alpha-1	0	1	38	39
Dual specificity testis-specific protein kinase 1	0	0	33	33
Myosin light chain kinase, smooth muscle	0	0	38	38
Serine/threonine-protein kinase STK11	0	0	38	38
Serine/threonine-protein kinase N1	0	0	38	38
Serine/threonine-protein kinase N2	0	1	38	39
Calcium/calmodulin-dependent protein kinase type IV	0	0	38	38
Mitogen-activated protein kinase kinase kinase 11	0	0	38	38
MAP kinase-activated protein kinase 3	0	0	15	15
Discoidin domain-containing receptor 2	0	4	38	42
AP2-associated protein kinase 1	0	1	38	39
Myosin light chain kinase 3	0	0	37	37
Uncharacterized aarF domain-containing protein kinase 5	0	0	24	24
Putative heat shock protein HSP 90-beta 2	0	0	37	37
Rab-like protein 3	0	0	32	32
Serine/threonine-protein kinase MRCK alpha	0	0	38	38
Serine/threonine-protein kinase MRCK gamma	0	0	36	36
Serine/threonine-protein kinase N3	0	0	29	29
Serine/threonine-protein kinase ULK3	0	0	38	38
Uncharacterized protein FLJ45252	0	0	38	38
Acyl-CoA dehydrogenase family member 11	0	0	36	36
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	37	37
Serine/threonine-protein kinase MARK2	0	0	38	38
Serine/threonine-protein kinase TAO1	0	0	38	38
STE20-related kinase adapter protein alpha	0	0	38	38
Myosin-14	0	0	35	35
AarF domain-containing protein kinase 1	0	0	38	38
ATP-dependent RNA helicase DDX42	0	0	34	34
Homeodomain-interacting protein kinase 1	0	2	13	15
Mitogen-activated protein kinase kinase kinase kinase 3	0	1	38	39
MAP kinase-activated protein kinase 5	0	0	36	36
Atypical kinase COQ8A, mitochondrial	0	0	38	38
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	38	38
Mitogen-activated protein kinase 15	0	0	38	38
Serine/threonine-protein kinase Nek9	0	0	38	38
ATP-dependent RNA helicase DDX1	0	0	37	37
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	38	38
Aurora kinase B	0	5	38	43
MAP/microtubule affinity-regulating kinase 4	0	0	36	36
Serine/threonine-protein kinase Nek1	0	0	38	38
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	38	38
EKC/KEOPS complex subunit TP53RK	0	0	38	38
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	2	38	40
Mitogen-activated protein kinase kinase kinase 5	0	0	38	38
Mitogen-activated protein kinase kinase kinase 3	0	0	38	38
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	38	38
Nucleolar GTP-binding protein 1	0	0	37	37
Serine/threonine-protein kinase D2	0	0	38	38
NUAK family SNF1-like kinase 2	0	0	37	37
RNA cytidine acetyltransferase	0	0	38	38
Serine/threonine-protein kinase SIK2	0	0	38	38
STE20-like serine/threonine-protein kinase	0	0	38	38
Serine/threonine-protein kinase TAO3	0	0	38	38
dCTP pyrophosphatase 1	0	0	38	38
Dual specificity protein kinase CLK4	0	0	32	32
Casein kinase I isoform gamma-1	0	0	38	38
Phenylalanine--tRNA ligase beta subunit	0	0	38	38
Isoleucine--tRNA ligase, mitochondrial	0	0	23	23
BMP-2-inducible protein kinase	0	0	38	38
Midasin	0	0	38	38
Interleukin-1 receptor-associated kinase 4	0	0	38	38
Mitogen-activated protein kinase kinase kinase 20	0	1	38	39
Cyclin-dependent kinase 12	0	0	38	38
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	37	37
Serine/threonine-protein kinase 26	0	1	38	39
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	33	33
Serine/threonine-protein kinase NLK	0	0	38	38
5'-AMP-activated protein kinase subunit gamma-2	0	0	38	38
Serine/threonine-protein kinase TBK1	0	2	38	40
Septin-9	0	0	38	38
Ribosomal protein S6 kinase alpha-6	0	0	38	38
TRAF2 and NCK-interacting protein kinase	0	0	38	38
Serine/threonine-protein kinase TAO2	0	0	38	38
Serine/threonine-protein kinase ICK	0	0	37	37
RAC-gamma serine/threonine-protein kinase	0	0	38	38
Serine/threonine-protein kinase SIK3	0	0	38	38
Mitogen-activated protein kinase kinase kinase 2	0	0	38	38
Thyroid hormone receptor-associated protein 3	0	0	30	30
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	38	38
Receptor-interacting serine/threonine-protein kinase 3	0	2	38	40
Serine/threonine-protein kinase MRCK beta	0	0	38	38
Interleukin-1 receptor-associated kinase 3	0	0	38	38
Serine/threonine-protein kinase 24	0	0	31	31
Casein kinase I isoform gamma-3	0	0	38	38
Mitogen-activated protein kinase kinase kinase 4	0	0	38	38
Tubulin beta-2B chain	0	2	1	5
Similar to alpha-tubulin isoform 1	0	2	1	5
Similar to alpha-tubulin isoform 1	0	2	0	4
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	13	0	0	13
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	9	0	0	9
Carbonic anhydrase 1	0	6	0	7
Carbonic anhydrase 2	0	7	1	9
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	2
Proton-coupled amino acid transporter 1	0	2	0	2
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	1
EWS/FLI fusion protein	46	0	0	46
Adenine phosphoribosyltransferase	0	0	27	27
Proto-oncogene tyrosine-protein kinase ROS	0	8	14	22
Tyrosine-protein kinase Fgr	0	2	23	25
Mast/stem cell growth factor receptor Kit	0	18	14	32
UMP-CMP kinase	0	0	22	22
Phosphatidylethanolamine-binding protein 1	0	0	29	29
Myosin-10	0	0	28	28
Vascular endothelial growth factor receptor 2	0	32	15	50
Electron transfer flavoprotein subunit beta	0	0	27	27
G protein-coupled receptor kinase 6	0	0	30	30
Cysteine--tRNA ligase, cytoplasmic	0	0	32	32
Dual specificity protein kinase CLK2	0	0	35	35
Serine/threonine-protein kinase PLK1	0	8	28	36
Mitogen-activated protein kinase 10	0	1	37	38
Cyclin-dependent kinase 3	0	0	35	35
Cyclin-dependent kinase 18	0	0	18	18
Tyrosine-protein kinase Mer	0	3	24	27
Integrin-linked protein kinase	0	0	36	36
Peroxisomal acyl-coenzyme A oxidase 1	0	0	33	33
Cyclin-dependent kinase 10	0	0	13	13
Ephrin type-A receptor 7	0	0	32	32
Acyl-CoA dehydrogenase family member 10	0	0	35	35
ATP-dependent RNA helicase DHX30	0	0	29	29
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	12	12
Misshapen-like kinase 1	0	0	24	24
PAS domain-containing serine/threonine-protein kinase	0	0	28	28
Dual specificity testis-specific protein kinase 2	0	0	22	22
SRSF protein kinase 1	0	1	13	14
Echinoderm microtubule-associated protein-like 4	0	5	2	8
Serine/threonine-protein kinase PAK 6	0	1	25	26
Obg-like ATPase 1	0	0	30	30
Serine/threonine-protein kinase pim-2	0	0	29	29
ALK tyrosine kinase receptor	0	12	21	34
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	11	2	14
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	25	25
AR protein	32	0	0	32
retinoic acid nuclear receptor alpha variant 1	23	0	0	23
estrogen nuclear receptor alpha	36	0	0	36
thyroid stimulating hormone receptor	9	0	0	9
thyroid hormone receptor beta isoform 2	28	0	0	28
Voltage-dependent calcium channel gamma-2 subunit	19	0	0	19
Heat shock protein HSP 90-alpha	0	1	2	3
Botulinum neurotoxin type A	0	2	0	2
Neutrophil cytosol factor 1	0	2	0	2
Glutamate receptor 2	19	0	0	19
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, brain	0	2	0	2
Nitric oxide synthase, brain	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Kappa-type opioid receptor	0	0	1	1
Phosphatidylinositol 4-kinase alpha	0	1	0	1
Mu-type opioid receptor	0	1	1	2
Tyrosine-protein kinase	0	0	1	1
Phosphatidylinositol 4-kinase type 2-beta	0	1	0	1
Phosphatidylinositol 4-kinase type 2-alpha	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	2	15	17
glucocorticoid receptor [Homo sapiens]	20	0	0	20
G	28	0	0	28
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	25	0	0	25
ATP-binding cassette sub-family C member 3	0	25	0	25
Multidrug resistance-associated protein 4	0	25	0	26
Bile salt export pump	0	32	0	32
HLA class I histocompatibility antigen, B alpha chain	28	0	0	28
Aromatase	0	8	0	8
Cytochrome P450 2C9	0	7	1	9
Amine oxidase [flavin-containing] A	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	2	0	4
Inositol hexakisphosphate kinase 1	28	0	0	28
Canalicular multispecific organic anion transporter 1	0	26	0	27
cytochrome P450 2C9, partial	28	0	0	28
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	2	0	2
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	2	0	2
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	2	0	2
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	2	0	2
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	2	0	2
Leukotriene C4 synthase	0	0	13	13
Luciferase	12	0	0	12
acetylcholinesterase	10	0	0	10
SMAD family member 2	9	0	0	9
SMAD family member 3	9	0	0	9
GLI family zinc finger 3	25	0	0	25
caspase 7, apoptosis-related cysteine protease	12	0	0	12
estrogen receptor 2 (ER beta)	20	0	0	20
progesterone receptor	19	0	0	19
farnesoid X nuclear receptor	22	0	0	22
peroxisome proliferator activated receptor gamma	21	0	0	21
vitamin D (1,25- dihydroxyvitamin D3) receptor	14	0	0	14
caspase-3	12	0	0	12
aryl hydrocarbon receptor	15	0	0	15
Histone H2A.x	10	0	0	10
histone deacetylase 9 isoform 3	4	0	0	4
tyrosine-protein kinase Yes	22	0	0	22
nuclear factor erythroid 2-related factor 2 isoform 1	23	0	0	23
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	5	15	20
Serine/threonine-protein kinase 25	0	0	13	13
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	14	14
Serine/threonine-protein kinase RIO3	0	0	13	13
Dual specificity mitogen-activated protein kinase kinase 7	0	0	13	13
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	1	13	14
Peripheral plasma membrane protein CASK	0	0	13	13
Serine/threonine-protein kinase DCLK1	0	0	13	13
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	13	13
Muscle, skeletal receptor tyrosine-protein kinase	0	0	13	13
3-phosphoinositide-dependent protein kinase 1	0	2	13	15
Mitogen-activated protein kinase kinase kinase 13	0	0	13	13
Death-associated protein kinase 3	0	0	13	13
Mitogen-activated protein kinase kinase kinase 7	0	0	13	13
NUAK family SNF1-like kinase 1	0	2	13	15
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	13	13
Tyrosine-protein kinase JAK2	0	6	22	28
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	13	13
Serine/threonine-protein kinase PAK 3	0	0	13	13
Serine/threonine-protein kinase 17B	0	0	13	13
Cyclin-dependent kinase 14	0	0	13	13
Serine/threonine-protein kinase OSR1	0	0	13	13
Serine/threonine-protein kinase Chk2	0	1	13	14
RAF proto-oncogene serine/threonine-protein kinase	0	7	14	23
Receptor tyrosine-protein kinase erbB-2	0	12	16	28
Cellular tumor antigen p53	25	0	0	25
Macrophage colony-stimulating factor 1 receptor	0	7	13	20
Cytochrome P450 3A4	0	18	1	23
Wee1-like protein kinase 2	0	0	13	13
Uncharacterized serine/threonine-protein kinase SBK3	0	0	13	13
Cytochrome P450 2D6	0	9	3	12
Insulin receptor-related protein	0	0	13	13
Platelet-derived growth factor receptor alpha	0	17	14	31
Vascular endothelial growth factor receptor 1	0	16	13	30
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	13	13
Serine/threonine-protein kinase MAK	0	0	13	13
Cyclin-dependent kinase 11B	0	0	13	13
Fibroblast growth factor receptor 2	0	3	13	17
Receptor tyrosine-protein kinase erbB-3	0	4	13	17
Fibroblast growth factor receptor 4	0	2	13	16
Fibroblast growth factor receptor 3	0	3	13	17
Protein kinase C eta type	0	1	13	14
Activin receptor type-2A	0	0	13	13
Ephrin type-A receptor 3	0	0	13	13
Ephrin type-A receptor 8	0	0	13	13
Leukocyte tyrosine kinase receptor	0	2	13	15
Tyrosine-protein kinase receptor UFO	0	3	13	16
Mitogen-activated protein kinase 4	0	0	13	13
G protein-coupled receptor kinase 4	0	0	13	13
Prostaglandin G/H synthase 2	0	2	13	15
Tyrosine-protein kinase receptor Tie-1	0	0	13	13
Vascular endothelial growth factor receptor 3	0	12	13	26
Serine/threonine-protein kinase receptor R3	0	0	18	18
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	8	16	24
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	4	15	19
Serine/threonine-protein kinase mTOR	0	9	17	26
Megakaryocyte-associated tyrosine-protein kinase	0	0	13	13
Tyrosine-protein kinase TXK	0	0	13	13
Tyrosine-protein kinase ZAP-70	0	2	13	15
Dual specificity mitogen-activated protein kinase kinase 4	0	0	22	22
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	4	15	19
Cyclin-dependent kinase 8	0	1	13	14
Tyrosine-protein kinase Blk	0	1	13	14
Cytoplasmic tyrosine-protein kinase BMX	0	1	13	14
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	13	13
Serine/threonine-protein kinase Nek4	0	0	13	13
Tyrosine-protein kinase JAK3	0	8	13	21
Death-associated protein kinase 1	0	0	13	13
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	1	13	14
Ephrin type-B receptor 1	0	0	13	13
Hormonally up-regulated neu tumor-associated kinase	0	0	13	13
Serine/threonine-protein kinase SIK1	0	0	13	13
Receptor-interacting serine/threonine-protein kinase 4	0	0	13	13
Cell division control protein 2 homolog	0	0	13	13
Calcium-dependent protein kinase 1	0	0	13	13
Casein kinase II subunit alpha	0	1	13	14
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	13	13
SRSF protein kinase 2	0	0	13	13
Mitogen-activated protein kinase kinase kinase 9	0	1	13	14
Serine/threonine-protein kinase PknB	0	0	13	13
Cyclin-dependent kinase-like 1	0	0	13	13
Protein kinase C epsilon type	0	1	13	14
Angiopoietin-1 receptor	0	5	13	18
Mitogen-activated protein kinase kinase kinase 10	0	0	13	13
Tyrosine-protein kinase receptor TYRO3	0	1	13	14
Tyrosine-protein kinase ITK/TSK	0	0	13	13
Myotonin-protein kinase	0	0	13	13
Mitogen-activated protein kinase kinase kinase 12	0	0	13	13
Serine/threonine-protein kinase PAK 1	0	0	13	13
cGMP-dependent protein kinase 2	0	0	13	13
Serine/threonine-protein kinase PRP4 homolog	0	0	13	13
Receptor-interacting serine/threonine-protein kinase 1	0	3	13	16
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	13	13
Serine/threonine-protein kinase D1	0	2	13	15
Serine/threonine-protein kinase 38	0	0	19	19
Receptor tyrosine-protein kinase erbB-4	0	5	13	18
Ribosomal protein S6 kinase alpha-2	0	0	13	13
Rhodopsin kinase GRK1	0	0	13	13
NT-3 growth factor receptor	0	4	13	17
BDNF/NT-3 growth factors receptor	0	5	13	18
Mitogen-activated protein kinase 6	0	0	13	13
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	13	13
Serine/threonine-protein kinase SBK1	0	0	13	13
Mitogen-activated protein kinase kinase kinase 19	0	0	13	13
Serine/threonine-protein kinase TNNI3K	0	1	13	14
Leucine-rich repeat serine/threonine-protein kinase 2	0	1	13	14
Serine/threonine-protein kinase Nek5	0	0	13	13
Dual serine/threonine and tyrosine protein kinase	0	1	13	14
Mitogen-activated protein kinase kinase kinase 15	0	0	13	13
Serine/threonine-protein kinase tousled-like 2	0	0	13	13
Serine/threonine-protein kinase 32C	0	0	13	13
Serine/threonine-protein kinase pim-3	0	0	13	13
Serine/threonine-protein kinase VRK2	0	0	13	13
Myosin light chain kinase family member 4	0	0	13	13
Calcium/calmodulin-dependent protein kinase type 1D	0	0	13	13
Cyclin-dependent kinase-like 3	0	0	13	13
Serine/threonine-protein kinase BRSK2	0	0	13	13
Serine/threonine-protein kinase NIM1	0	1	13	14
Serine/threonine-protein kinase ULK2	0	0	13	13
Serine/threonine-protein kinase DCLK2	0	0	13	13
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	13	13
Casein kinase I isoform alpha-like	0	0	13	13
Homeodomain-interacting protein kinase 4	0	1	13	14
Myosin-IIIa	0	0	13	13
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	13	13
Serine/threonine-protein kinase Nek11	0	0	13	13
Serine/threonine-protein kinase BRSK1	0	0	13	13
Serine/threonine-protein kinase 35	0	0	13	13
Serine/threonine-protein kinase Nek7	0	0	27	27
Rhodopsin kinase GRK7	0	0	13	13
Serine/threonine-protein kinase 32A	0	0	13	13
Myosin-IIIb	0	0	13	13
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	13	13
Cyclin-dependent kinase-like 2	0	0	13	13
Serine/threonine-protein kinase Sgk3	0	0	13	13
Atypical kinase COQ8B, mitochondrial	0	0	13	13
Calcium/calmodulin-dependent protein kinase type 1G	0	0	17	17
Cyclin-dependent kinase 15	0	0	13	13
ATPase family AAA domain-containing protein 5	17	0	0	17
Ataxin-2	18	0	0	18
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	13	13
Serine/threonine-protein kinase RIO1	0	0	13	13
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	13	13
Serine/threonine-protein kinase RIO2	0	0	13	13
Cyclin-dependent kinase 19	0	1	13	14
Transient receptor potential cation channel subfamily M member 6	0	0	13	13
Testis-specific serine/threonine-protein kinase 1	0	1	13	14
Serine/threonine-protein kinase 33	0	0	13	13
Serine/threonine-protein kinase DCLK3	0	0	13	13
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	13	13
Homeodomain-interacting protein kinase 2	0	1	13	14
Tyrosine-protein kinase Srms	0	0	13	13
Homeodomain-interacting protein kinase 3	0	1	13	14
Serine/threonine-protein kinase PLK3	0	4	13	17
MAP kinase-interacting serine/threonine-protein kinase 2	0	2	13	15
Serine/threonine-protein kinase Nek6	0	1	13	14
SNF-related serine/threonine-protein kinase	0	0	13	13
Serine/threonine-protein kinase LATS2	0	0	13	13
Serine/threonine-protein kinase 36	0	0	13	13
Serine/threonine-protein kinase 32B	0	0	13	13
Serine/threonine-protein kinase PLK2	0	4	13	17
Serine/threonine-protein kinase MARK1	0	1	13	14
Serine/threonine-protein kinase PAK 5	0	1	13	14
eIF-2-alpha kinase GCN2	0	0	13	13
Serine/threonine-protein kinase 17A	0	0	13	13
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	13	13
Ephrin type-A receptor 6	0	0	13	13
Death-associated protein kinase 2	0	0	13	13
Serine/threonine-protein kinase tousled-like 1	0	0	13	13
Long-chain-fatty-acid--CoA ligase 5	0	0	28	28
SRSF protein kinase 3	0	0	13	13
Cyclin-dependent kinase 11A	0	0	13	13
Aurora kinase C	0	0	13	13
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	13	13
Serine/threonine-protein kinase 38-like	0	0	22	22
Microtubule-associated serine/threonine-protein kinase 1	0	0	13	13
Membrane-associated progesterone receptor component 1	0	0	25	25
Phosphatidylinositol 3-kinase regulatory subunit alpha	0	3	0	3
Regulatory-associated protein of mTOR	0	3	0	3
Phosphatidylinositol 3-kinase catalytic subunit type 3	0	1	2	3
Target of rapamycin complex subunit LST8	0	3	0	3
Cytochrome P450 1A2	0	9	1	11
Cytochrome P450 2E1	0	2	0	2
Cytochrome P450 2C8	0	5	0	6
Cytochrome P450 2C19	0	9	1	10
Dipeptidyl peptidase 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	4
Chain A, Putative fructose-1,6-bisphosphate aldolase	5	0	0	5
Chain A, HADH2 protein	7	0	0	7
Chain B, HADH2 protein	7	0	0	7
Chain A, 2-oxoglutarate Oxygenase	10	0	0	10
Chain A, Cruzipain	6	0	0	6
phosphopantetheinyl transferase	11	0	0	11
Microtubule-associated protein tau	10	0	0	10
aldehyde dehydrogenase 1 family, member A1	13	0	0	13
caspase-1 isoform alpha precursor	3	0	0	3
lamin isoform A-delta10	17	0	0	17
Caspase-7	3	0	0	3
Inositol monophosphatase 1	4	0	0	4
Solute carrier organic anion transporter family member 1B3	0	10	0	12
Solute carrier organic anion transporter family member 1B1	0	9	0	11
interferon gamma precursor	0	0	0	4
Poly [ADP-ribose] polymerase tankyrase-1	0	4	3	7
Poly [ADP-ribose] polymerase 1	0	9	8	17
Protein mono-ADP-ribosyltransferase PARP14	0	2	2	4
Protein mono-ADP-ribosyltransferase PARP10	0	3	4	7
Protein mono-ADP-ribosyltransferase PARP8	0	0	3	3
Protein mono-ADP-ribosyltransferase PARP16	0	1	4	5
Protein mono-ADP-ribosyltransferase PARP12	0	3	2	5
Poly [ADP-ribose] polymerase 2	0	7	8	15
Protein mono-ADP-ribosyltransferase PARP4	0	3	4	7
Protein mono-ADP-ribosyltransferase PARP3	0	3	8	11
Fumarate hydratase	26	0	0	26
polyprotein	26	0	0	26
Cholinesterase	0	2	0	3
Gastrin/cholecystokinin type B receptor	0	1	0	1
Vascular endothelial growth factor receptor 2	0	5	0	5
Chain A, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	1	0	1
Cytochrome P450 2B6	0	2	0	2
Nucleoside diphosphate kinase B	0	0	5	5
Aldo-keto reductase family 1 member C3	0	2	0	2
DNA-dependent protein kinase catalytic subunit	0	4	1	5
Phosphoinositide 3-kinase regulatory subunit 5	0	1	0	1
Serine/threonine-protein kinase mTOR	0	2	0	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Kinesin-1 heavy chain	0	3	0	3
Coiled-coil domain-containing protein 6	0	3	0	3
SAFB-like transcription modulator	0	1	0	1
Chain A, Ferritin light chain	6	0	0	6
DNA topoisomerase	0	1	0	1
15-lipoxygenase, partial	5	0	0	5
NFKB1 protein, partial	1	0	0	1
thyroid stimulating hormone receptor	4	0	0	4
regulator of G-protein signaling 4	5	0	0	5
67.9K protein	13	0	0	13
glucocerebrosidase	3	0	0	3
putative alpha-glucosidase	1	0	0	1
alpha-galactosidase	2	0	0	2
Bloom syndrome protein isoform 1	7	0	0	7
lysosomal alpha-glucosidase preproprotein	3	0	0	3
peripheral myelin protein 22 isoform 1	3	0	0	3
hemoglobin subunit beta	2	0	0	2
cellular tumor antigen p53 isoform a	4	0	0	4
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 2	8	0	0	8
huntingtin isoform 2	4	0	0	4
eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor	0	0	1	1
serine/threonine-protein kinase mTOR isoform 1	5	0	0	5
nuclear receptor ROR-gamma isoform 1	11	0	0	11
survival motor neuron protein isoform d	9	0	0	9
cytochrome P450 3A4 isoform 1	8	0	0	8
M-phase phosphoprotein 8	6	0	0	6
muscleblind-like protein 1 isoform 1	6	0	0	6
relaxin receptor 1 isoform 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	8	1	1	10
Telomerase reverse transcriptase	0	1	0	1
Histone deacetylase 3	0	5	1	9
Type-2 restriction enzyme ScaI	0	1	0	1
Deoxyribonuclease-2-alpha	0	1	0	1
Tyrosyl-DNA phosphodiesterase 2	0	1	0	1
Deoxyribonuclease-1	0	1	0	1
Type-2 restriction enzyme PstI	0	1	0	1
Type-2 restriction enzyme EcoRI	0	1	0	1
Prothrombin	0	0	0	2
DNA ligase	0	1	0	1
Integrin beta-3	4	1	0	5
Integrin alpha-IIb	4	0	0	4
Heterogeneous nuclear ribonucleoprotein A1	0	0	1	1
DNA topoisomerase 1	0	3	3	13
Gamma-aminobutyric acid receptor subunit beta-1	8	1	1	10
Gamma-aminobutyric acid receptor subunit delta	8	1	1	10
Gamma-aminobutyric acid receptor subunit gamma-2	8	1	1	10
Gamma-aminobutyric acid receptor subunit alpha-5	8	1	1	10
Gamma-aminobutyric acid receptor subunit alpha-3	8	1	1	10
Gamma-aminobutyric acid receptor subunit gamma-1	8	1	1	10
Gamma-aminobutyric acid receptor subunit alpha-2	8	1	1	10
Type-2 restriction enzyme BamHI	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	8	1	1	10
Gamma-aminobutyric acid receptor subunit gamma-3	8	1	1	10
Gamma-aminobutyric acid receptor subunit alpha-6	8	1	1	10
Somatostatin receptor type 1	0	2	0	2
Somatostatin receptor type 2	0	2	0	2
Somatostatin receptor type 4	0	2	0	2
Somatostatin receptor type 3	0	2	0	2
Somatostatin receptor type 5	0	2	0	2
5-hydroxytryptamine receptor 2B	0	9	1	10
Type-2 restriction enzyme HindIII	0	1	0	1
D(1A) dopamine receptor	3	1	0	4
Histone deacetylase 4	0	5	1	9
Ribonuclease pancreatic	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	8	1	1	10
Gamma-aminobutyric acid receptor subunit beta-3	8	1	1	10
Gamma-aminobutyric acid receptor subunit beta-2	8	1	1	10
DNA topoisomerase 1	0	2	0	3
Histone deacetylase 1	0	5	2	10
DNA topoisomerase 1	0	1	0	1
Integrase	0	2	0	2
Histone deacetylase 7	0	5	2	10
GABA theta subunit	8	1	1	10
Histone deacetylase 2	0	5	2	10
DNA topoisomerase type IB small subunit	0	0	1	1
Polyamine deacetylase HDAC10	0	5	1	9
Histone deacetylase 11	0	5	1	9
Histone deacetylase 8	0	5	2	10
Gamma-aminobutyric acid receptor subunit epsilon	8	1	1	10
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Histone deacetylase 6	0	5	2	10
Histone deacetylase 9	0	5	1	9
Histone deacetylase 5	0	5	1	9
Liver carboxylesterase 1	0	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
Chain A, serum paraoxonase	0	1	0	1
Carbonic anhydrase 12	0	4	0	4
Carbonic anhydrase 3	0	2	0	2
Carbonic anhydrase 4	0	2	0	2
Carbonic anhydrase 6	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	3	0	3
Carbonic anhydrase 7	0	3	0	3
Carbonic anhydrase 9	0	6	0	6
Carbonic anhydrase 13	0	1	0	1
Poly [ADP-ribose] polymerase tankyrase-2	0	4	3	7
Carbonic anhydrase 14	0	3	0	3
Carbonic anhydrase 5B, mitochondrial	0	2	0	2
Nucleophosmin	0	2	0	2
ATP-dependent translocase ABCB1	0	10	6	19
Transcription factor ETV6	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	0	1	0	1
Sodium-dependent phosphate transport protein 2B	0	2	0	2
Tyrosine-protein kinase ABL1	0	2	0	2
HLA class II histocompatibility antigen gamma chain	0	2	0	2
Androgen receptor	0	1	0	1
ALK tyrosine kinase receptor	0	1	0	1
Angiopoietin-1 receptor	0	1	0	1
Lysine--tRNA ligase	0	1	0	1
Macrophage-stimulating protein receptor	0	1	0	1
Mixed lineage kinase domain-like protein	0	0	1	1
Aurora kinase A-interacting protein	0	1	0	1
Pirin	0	2	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	4	4
GTPase KRas	0	2	0	2
Heat shock factor protein 1	0	2	0	2
interleukin 8	3	0	0	3
hypoxia-inducible factor 1 alpha subunit	12	0	0	12
activating transcription factor 6	10	0	0	10
Matrix metalloproteinase-9	0	2	0	2
Isocitrate lyase	0	1	0	1
Adenosine receptor A3	0	6	1	7
D(1A) dopamine receptor	0	4	1	5
Adenosine receptor A2a	0	4	1	5
Cyclin-A1	0	3	0	3
heat shock protein beta-1	9	0	0	9
Sex hormone-binding globulin	0	0	1	1
Beta-glucuronidase	0	1	0	1
Corticosteroid-binding globulin	0	1	0	1
Beta-glucuronidase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	3	0	3
Alpha-synuclein	5	1	0	6
TAR DNA-binding protein 43	4	0	0	4
G-protein coupled bile acid receptor 1	0	0	1	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
Thymidine kinase 2	0	1	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	0	0	2
AAA family ATPase	0	0	0	2
Reverse transcriptase/RNaseH	0	0	1	1
ClpP	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	7	0	0	7
v-jun sarcoma virus 17 oncogene homolog (avian)	9	0	0	9
Glycoprotein hormones alpha chain	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	5	0	0	5
Serum paraoxonase/arylesterase 1	0	4	0	4
Kinesin-like protein KIF11	0	2	0	2
Nucleotide-binding oligomerization domain-containing protein 2	0	2	0	2
Eukaryotic elongation factor 2 kinase	0	1	0	1
Putative nucleoside diphosphate kinase	0	0	3	3
Casein kinase II subunit beta	0	1	0	1
Serine/threonine-protein kinase LMTK3	0	1	0	1
Eukaryotic translation initiation factor 2-alpha kinase 3	0	1	0	1
Protein DBF4 homolog A	0	1	0	1
Genome polyprotein	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	1	0	2
Serine/threonine-protein kinase B-raf	0	3	0	3
glp-1 receptor, partial	5	0	0	5
LMP1 [Human herpesvirus 4]	0	0	0	2
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	2	0	2
transactivating tegument protein VP16 [Human herpesvirus 1]	0	2	0	2
nuclear receptor coactivator 3 isoform a	0	2	0	2
Regulatory protein E2	0	0	1	1
ATP-dependent translocase ABCB1	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
DNA topoisomerase 2	0	0	0	1
ATP-dependent translocase ABCB1	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	2
Caspase-3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
DNA topoisomerase 2-alpha	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
peripheral myelin protein 22	11	0	0	11
Potassium voltage-gated channel subfamily E member 1	0	4	0	4
Potassium voltage-gated channel subfamily KQT member 1	0	4	0	4
Sodium channel protein type 5 subunit alpha	0	5	0	5
Potassium voltage-gated channel subfamily D member 3	0	3	0	3
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
endonuclease IV	1	0	0	1
Skn7p	0	0	0	1
pregnane X receptor	5	0	0	5
nonstructural protein 1	3	0	0	3
arylsulfatase A	6	0	0	6
IDH1	6	0	0	6
Vpr	1	0	0	1
Solute carrier family 22 member 8	0	0	0	1
Amyloid-beta precursor protein	1	2	0	3
Thymidylate synthase	0	4	0	5
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
GALC protein	2	0	0	2
Estrogen receptor	0	5	3	11
Estrogen receptor	0	1	1	3
Progesterone receptor	0	2	0	2
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	3
Steroid hormone receptor ERR1	0	2	0	2
Bifunctional epoxide hydrolase 2	0	5	0	5
Beta-lactamase TEM	0	1	0	1
Estrogen receptor beta	0	4	1	5
Bile acid receptor	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	3	0	3
Albumin	0	1	2	3
Albumin	0	0	1	1
Sodium-dependent dopamine transporter	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Smoothened homolog	0	1	1	2
Sonic hedgehog protein	0	1	0	2
Sonic hedgehog protein	0	2	0	2
Smoothened homolog	0	3	2	5
Caspase-7	7	0	0	7
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
caspase-3	7	0	0	7
epidermal growth factor receptor isoform a precursor	1	1	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
Quinolone resistance protein NorA	0	1	0	1
Myosin light chain kinase, smooth muscle	0	0	5	5
Cruzipain	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Mitogen-activated protein kinase kinase kinase 8	0	2	0	2
Histamine H2 receptor	3	1	0	4
Beta-secretase 1	0	1	0	1
Tubulin alpha-1A chain	0	0	5	5
Synaptic vesicular amine transporter	0	1	0	1
Transcription factor p65	0	1	0	1
Serine/threonine-protein kinase ULK3	0	0	2	2
Chain A, DEOXYNUCLEOSIDE KINASE	0	1	0	1
Spike glycoprotein	0	0	3	3
Replicase polyprotein 1ab	0	0	3	3
Transmembrane protease serine 2	0	0	3	3
Procathepsin L	0	0	3	3
Replicase polyprotein 1a	0	0	3	3
Replicase polyprotein 1ab	0	0	3	3
Replicase polyprotein 1ab	0	0	3	3
Equilibrative nucleoside transporter 1	0	1	0	1
Angiotensin-converting enzyme 2	0	0	3	3
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Mcl-1	0	2	0	2
Estrogen receptor 1	0	1	0	1
thioredoxin glutathione reductase	5	0	0	5
Smad3	5	0	0	5
DNA polymerase III, partial	2	0	0	2
PINK1	1	0	0	1
Parkin	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
galactokinase	2	0	0	2
hexokinase-4 isoform 1	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	4	0	0	4
polyunsaturated fatty acid lipoxygenase ALOX12	4	0	0	4
cytochrome P450 2C9 precursor	1	0	0	1
D(1A) dopamine receptor	3	0	0	3
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
thyroid hormone receptor beta isoform a	4	0	0	4
glucokinase regulatory protein	1	0	0	1
DNA polymerase beta	3	0	0	3
mitogen-activated protein kinase 1	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
4-(cytidine 5'-phospho)-2-C-methyl-D-erithritol kinase	1	0	0	1
neuropeptide S receptor isoform A	2	0	0	2
Prolyl endopeptidase	0	1	0	1
L-lactate dehydrogenase A chain	0	1	0	1
Malate dehydrogenase, mitochondrial	0	1	0	1
L-lactate dehydrogenase B chain	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Apoptosis regulator Bcl-2	0	3	2	5
Muscarinic acetylcholine receptor M2	0	2	0	2
Solute carrier family 2, facilitated glucose transporter member 1	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
L-lactate dehydrogenase B chain	0	1	0	1
DNA-3-methyladenine glycosylase	0	1	0	1
Caspase-1	1	1	0	2
DNA repair protein RAD52 homolog	0	1	0	1
5-hydroxytryptamine receptor 7	0	2	0	2
BH3-interacting domain death agonist	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Type 1 InsP3 receptor isoform S2	1	0	0	1
E3 ubiquitin-protein ligase Mdm2	0	4	1	5
Bcl-2-like protein 1	0	3	1	4
Induced myeloid leukemia cell differentiation protein Mcl-1	0	2	1	3
Peroxisome proliferator-activated receptor alpha	1	0	0	1
L-lactate dehydrogenase	0	1	0	1
Aspartyl/asparaginyl beta-hydroxylase	0	2	0	2
L-lactate dehydrogenase	0	1	0	1
L-lactate dehydrogenase B chain	0	1	0	1
L-lactate dehydrogenase	0	1	0	1
Bcl-2-like protein 2	0	1	0	1
Bcl2-associated agonist of cell death	0	1	0	1
Inosine-5'-monophosphate dehydrogenase	0	1	0	1
Histamine H3 receptor	1	0	0	1
phosphoglycerate kinase	1	0	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Valosin-containing protein	0	1	0	1
pyruvate kinase	1	0	0	1
estrogen receptor beta isoform 1	0	1	0	1
pyruvate kinase PKM isoform a	1	0	0	1
eyes absent homolog 2 isoform a	1	0	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
60 kDa chaperonin	0	3	0	3
60 kDa heat shock protein, mitochondrial	0	3	0	3
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Endothelin receptor type B	1	0	0	1
Adenosine receptor A1	1	0	0	1
Endothelin-1 receptor	1	0	0	1
10 kDa heat shock protein, mitochondrial	0	3	0	3
Thiosulfate sulfurtransferase	0	3	0	3
60 kDa chaperonin	0	3	0	3
10 kDa chaperonin	0	3	0	3
Purine nucleoside phosphorylase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Shiga toxin subunit A	0	1	0	1
Guanine deaminase	0	0	0	1
Chain A, Beta-lactamase	5	0	0	5
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Cytochrome P450 3A5	0	2	0	3
Chain A, Cell Division Protein Kinase 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
DNA repair and recombination protein RadA	0	0	1	1
Indoleamine 2,3-dioxygenase 1	0	1	1	2
Chain A, Acetylcholinesterase	0	1	0	1
Solute carrier family 22 member 2	0	4	0	4
Solute carrier family 22 member 1	0	5	0	5
Solute carrier family 22 member 3	0	3	0	3
Interstitial collagenase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Muscarinic acetylcholine receptor M4	0	4	0	4
Alpha-2C adrenergic receptor	0	3	2	6
Acetylcholinesterase	0	5	0	5
Multidrug and toxin extrusion protein 2	0	3	0	3
Multidrug and toxin extrusion protein 1	0	4	0	4
Chymotrypsinogen A	0	1	0	1
Chain A, Epidermal growth factor receptor	0	1	0	1
dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
Alpha-1A adrenergic receptor	0	1	0	1
Cereblon isoform 4	0	3	0	3
Bromodomain-containing protein 4	0	2	0	2
DNA-binding protein Ikaros	0	0	1	4
DNA damage-binding protein 1	0	2	1	3
Protein cereblon	0	6	2	11
Zinc finger protein Aiolos	0	0	1	1
Nuclear receptor coactivator 4	0	1	0	1
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
Steryl-sulfatase	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
D(2) dopamine receptor	0	1	0	1
TGF-beta receptor type-1	0	1	0	1
muscarinic acetylcholine receptor M1	2	0	0	2
Cytochrome P450 1A1	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Myeloperoxidase	0	1	0	1
Cytochrome P450 2C11	0	1	0	1
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Nociceptin receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	7	1	8
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear receptor ROR-gamma	3	1	1	5
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Cytochrome P450 1B1	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Histamine H3 receptor	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Dihydrofolate reductase	0	5	0	6
Dipeptidyl peptidase 4	0	1	0	1
Solute carrier family 22 member 1	0	0	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	2	0	2
transcriptional regulator ERG isoform 3	2	0	0	2
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Bile salt export pump	0	2	0	2
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	3	0	4
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	3	0	4
Thymidylate synthase	0	3	0	3
Thymidylate synthase	0	4	0	4
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	3	2	5
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	2	0	2
5-hydroxytryptamine receptor 2A	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	2	0	2
Dihydrofolate reductase	0	3	0	3
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	3	0	3
Bifunctional purine biosynthesis protein ATIC	0	4	0	4
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	3	0	3
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	2
Canalicular multispecific organic anion transporter 1	0	2	0	4
Trifunctional purine biosynthetic protein adenosine-3	0	2	0	2
Solute carrier family 22 member 20	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Solute carrier family 22 member 6	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	3	0	4
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	1	0	2
Protein-arginine deiminase type-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Aurora kinase A	0	2	0	2
Inner centromere protein	0	1	0	1
Targeting protein for Xklp2	0	1	0	1
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	1	0	1
Tissue factor	0	1	0	1
NAD-dependent protein deacetylase HST2	0	1	0	1
Fatty-acid amide hydrolase 1	0	3	0	3
Protein mono-ADP-ribosyltransferase PARP15	0	3	0	3
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	2	0	2
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacetylase	0	1	0	1
Platelet-derived growth factor receptor beta	0	3	0	3
Platelet-derived growth factor receptor alpha	0	2	0	2
Protein mono-ADP-ribosyltransferase PARP6	0	1	0	1
Histamine H3 receptor	0	1	0	1
Lysine-specific histone demethylase 1A	0	2	0	2
von Hippel-Lindau disease tumor suppressor	0	1	0	1
Epidermal growth factor receptor	0	2	0	2
Tubulin alpha-1A chain	0	1	1	3
Tubulin beta chain	0	1	1	2
Tubulin beta-4A chain	0	1	1	3
Integrin alpha-V	0	1	0	1
Tubulin beta chain	0	1	1	3
Tubulin alpha-3C chain	0	1	1	3
UDP-glucuronosyltransferase 1-6	0	1	0	1
Substance-K receptor	0	4	0	4
Cholecystokinin receptor type A	0	3	1	4
Melanocortin receptor 5	0	4	0	4
UDP-glucuronosyltransferase 2B10	0	1	0	1
Delta-type opioid receptor	0	6	1	7
Tubulin alpha-1B chain	0	1	1	3
Tubulin alpha-4A chain	0	1	1	3
Tubulin beta-4B chain	0	1	1	3
Tubulin beta-3 chain	0	2	1	4
Tubulin beta-2A chain	0	1	1	3
Beta-tubulin	0	1	0	1
Tubulin beta-8 chain	0	1	1	3
Tubulin alpha-3E chain	0	1	1	3
Tubulin alpha-1A chain	0	1	1	3
Tubulin alpha-1C chain	0	1	1	3
Tubulin beta-6 chain	0	1	1	3
Tubulin beta-2B chain	0	1	1	3
Tubulin beta-1 chain	0	1	1	3
Chain B, Cell division protein kinase 6	0	1	0	1
Chain B, Cell division protein kinase 6	0	1	0	1
Acetylcholinesterase	0	1	0	1
G1/S-specific cyclin-D2	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Fatty acid synthase	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	2	0	2
Receptor protein-tyrosine kinase	0	1	0	1
Chain A, Thymidylate Synthase	0	1	0	1
Chain A, Thymidylate Synthase	0	1	0	1
Chain A, Thymidylate Synthase	0	1	0	1
Serine hydroxymethyltransferase, cytosolic	0	1	1	2
Thymidylate synthase	0	1	0	1
Macrophage colony-stimulating factor 1 receptor	0	2	0	2
Presenilin-1	0	1	0	1
Presenilin-2	0	1	0	1
Gamma-secretase subunit APH-1B	0	1	0	1
Nicastrin	0	1	0	1
Gamma-secretase subunit APH-1A	0	1	0	1
Gamma-secretase subunit PEN-2	0	1	0	1
Chain A, AKAP9-BRAF fusion protein	0	1	0	1
Dual specificity mitogen-activated protein kinase kinase 4	0	0	1	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	3
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
Insulin receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Solute carrier family 22 member 7	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Solute carrier family 22 member 7	0	1	0	1
Glucocorticoid receptor	0	2	1	3
Glycine receptor subunit alpha-1	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Beta-1 adrenergic receptor	0	1	1	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
5-hydroxytryptamine receptor 4	0	4	0	4
Beta-2 adrenergic receptor	0	2	1	3
Muscarinic acetylcholine receptor M2	0	3	1	4
Beta-1 adrenergic receptor	0	4	1	5
5-hydroxytryptamine receptor 1A	0	2	0	2
Alpha-2A adrenergic receptor	0	3	2	6
Beta-2 adrenergic receptor	0	2	0	3
Muscarinic acetylcholine receptor M1	0	3	1	4
Beta-3 adrenergic receptor	0	4	1	5
D(2) dopamine receptor	0	3	1	4
Alpha-1B adrenergic receptor	0	6	1	7
Alpha-2B adrenergic receptor	0	2	1	4
Beta-1 adrenergic receptor	0	2	1	4
D(3) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	6	1	8
Alpha-2B adrenergic receptor	0	0	1	1
Muscarinic acetylcholine receptor M3	0	3	1	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Alpha-2C adrenergic receptor	0	0	1	1
Alpha-2A adrenergic receptor	0	0	1	1
Alpha-1D adrenergic receptor	0	3	1	4
Alpha-1D adrenergic receptor	0	2	1	4
Endothelin-1 receptor	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
5-hydroxytryptamine receptor 2A	0	5	1	6
5-hydroxytryptamine receptor 2C	0	5	1	6
5-hydroxytryptamine receptor 1B	0	4	0	4
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Sodium-dependent serotonin transporter	0	4	0	4
5-hydroxytryptamine receptor 7	0	2	1	3
Beta-1 adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	2	4
Alpha-1B adrenergic receptor	0	0	1	2
Mu-type opioid receptor	0	3	1	4
Vasopressin V1a receptor	0	1	1	2
Kappa-type opioid receptor	0	3	1	4
5-hydroxytryptamine receptor 6	0	5	1	6
Cytochrome P450 2J2	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Beta-2 adrenergic receptor	0	1	1	3
Sigma non-opioid intracellular receptor 1	0	4	0	4
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Glycine receptor subunit alpha-1	0	0	1	1
Vascular endothelial growth factor receptor 3	0	2	0	2
GDH/6PGL endoplasmic bifunctional protein	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP9	0	0	1	1
Protein mono-ADP-ribosyltransferase PARP11	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Proto-oncogene tyrosine-protein kinase Src	0	1	1	2
Low-density lipoprotein receptor	0	1	0	1
Fibronectin	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 4	0	1	0	1
Ras-related C3 botulinum toxin substrate 1	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Multidrug resistance-associated protein 1	0	1	0	1
Proprotein convertase subtilisin/kexin type 9	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Chain A, Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Acetylcholinesterase	0	1	0	1
Pyruvate kinase PKM	0	0	1	1
Neutral amino acid transporter A	0	1	0	1
Cholinesterase	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Eukaryotic translation initiation factor 4E	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Programmed cell death protein 4	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
melanocortin receptor 4	0	1	1	2
Cyclin-C	0	1	1	2
Delta-type opioid receptor	0	0	1	1
5-hydroxytryptamine receptor 5A	0	1	0	1
Protein delta homolog 1	0	1	2	3
Vascular endothelial growth factor receptor 2	0	1	0	1
RuvB-like 2	0	1	1	2
RuvB-like 1	0	1	0	1
Mast/stem cell growth factor receptor Kit	0	1	0	1
Translocator protein	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
Bromodomain-containing protein 9	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Bromodomain-containing protein 7	0	0	1	1
Chain A, CES1 protein	0	1	0	1
thyrotropin-releasing hormone receptor	2	0	0	2
ubiquitin-conjugating enzyme E2 N	0	1	0	1
streptokinase A precursor	0	0	1	1
Lysosomal acid glucosylceramidase	0	0	1	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Androgen receptor	0	3	0	3
D(4) dopamine receptor	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Thromboxane-A synthase	0	1	0	1
Histamine H2 receptor	0	2	0	2
Substance-P receptor	0	2	0	2
B2 bradykinin receptor	0	2	0	2
Adenosine receptor A1	0	2	0	2
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	1	0	1
D(3) dopamine receptor	0	2	0	2
Melanocortin receptor 3	0	2	0	2
Estrogen-related receptor gamma	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Platelet-activating factor acetylhydrolase	0	2	0	2
Phospholipase D1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	1	3
Estrogen receptor beta	0	0	1	2
Protein kinase C eta type	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Emopamil-binding protein-like	0	1	0	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
polyadenylate-binding protein 1	0	1	0	1
Alpha-enolase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Thymidine phosphorylase	0	1	0	1
NPYLR7B	0	0	1	1
Hypoxia-inducible factor 1-alpha	0	1	1	2
Endothelial PAS domain-containing protein 1	0	0	1	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Ornithine decarboxylase	0	0	0	1
Ornithine decarboxylase	0	0	0	1
Retinoic acid receptor alpha	0	2	2	7
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Retinoic acid receptor gamma	0	2	2	7
Alpha-1A adrenergic receptor	0	1	0	1
Retinoic acid receptor gamma	0	1	2	3
Retinoic acid receptor RXR-alpha	0	2	2	4
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Nuclear receptor ROR-alpha	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	0	1	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Nuclear receptor ROR-beta	0	1	0	1
Thymidine kinase	0	1	0	1
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Chain A, Uracil-DNA Glycosylase	0	1	0	1
Chain A, Arginase 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Chain A, Histone deacetylase-like amidohydrolase	0	1	0	1
Chain A, Histone deacetylase-like amidohydrolase	0	1	0	1
Histone deacetylase 8	0	1	0	1
Nrf2	1	0	0	1
PAX8	0	0	0	1
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
Histone deacetylase	0	1	0	1
Lysine-specific demethylase 4E	0	1	0	1
Gli1	0	1	0	1
nuclear receptor subfamily 0 group B member 1	0	1	0	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
steroidogenic factor 1	0	1	0	1
protein Wnt-3a precursor	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Histone deacetylase 1	0	2	0	2
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Nuclear receptor corepressor 1	0	2	0	2
Protein Tat	0	0	1	1
Leukotriene A-4 hydrolase	0	1	0	1
Aminopeptidase N	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX12	0	0	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Proteasome subunit beta type-5	0	1	0	1
Apoptosis regulator BAX	0	0	1	1
Histone deacetylase 1	0	1	0	1
Histone deacetylase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Renin	0	1	0	1
Histone deacetylase 3	0	1	0	1
Histone deacetylase-like amidohydrolase	0	2	1	3
Histone deacetylase	0	1	0	1
HD2 type histone deacetylase HDA106	0	2	0	2
Carboxypeptidase B2	0	1	0	1
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 4	0	1	0	1
REST corepressor 3	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Histone deacetylase	0	1	0	1
Nuclear receptor corepressor 2	0	2	0	2
Histone deacetylase 6	0	1	0	1
Histone deacetylase	0	1	0	1
Butyrophilin subfamily 3 member A1	0	0	1	2
Geranylgeranyl pyrophosphate synthase	0	2	0	3
72 kDa type IV collagenase	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Neutrophil collagenase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
Matrix metalloproteinase-14	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Geranylgeranyl pyrophosphate synthase	0	2	0	2
Farnesyl pyrophosphate synthase	0	1	0	1
H	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Response Evaluation Criteria in Solid Tumors

Synonyms(1)

Research

Studies (397)

Protein Targets (1,484)

Response Evaluation Criteria in Solid Tumors

Synonyms(1)

Research

Studies (397)

Drugs Studied (174)

Protein Targets (1,484)