triazoles has been researched along with oxadiazoles in 135 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (8.15) | 18.7374 |
| 1990's | 7 (5.19) | 18.2507 |
| 2000's | 43 (31.85) | 29.6817 |
| 2010's | 58 (42.96) | 24.3611 |
| 2020's | 16 (11.85) | 2.80 |
| Authors | Studies |
|---|---|
| Bonina, F; Mazzone, G | 1 |
| Cheng, CC; Daves, GD | 1 |
| Imai, K; Mano, M; Matsuno, T; Seo, T | 1 |
| Aboul Wafa, OM; Berto, FA | 1 |
| Papadaki-Valiraki, A; Papadopoulou-Daifoiti, Z; Siatra-Papastaikoudi, T; Tsitsa, P; Vamvakidis, A | 1 |
| Boden, P; Bycroft, BW; Chhabra, SR; Chiplin, J; Crowley, PJ; Grout, RJ; King, TJ; McDonald, E; Rafferty, P; Usherwood, PN | 1 |
| Bhaduri, AP; Kamboj, VP; Mehrotra, PK | 1 |
| Pandey, HN; Ram, VJ | 1 |
| Albrecht, B; Bräuniger, H | 1 |
| Abd El-Fattah, B; Al-Ashmawi, MI; Hassan, E | 1 |
| Farkas, I; Mahmoud, SH; Somsák, L | 1 |
| Connor, DT; Dyer, RD; Kostlan, CR; Mullican, MD; Schrier, DJ; Wilson, MW | 1 |
| Bornemeier, DA; Boschelli, DH; Connor, DT; Dyer, RD; Kennedy, JA; Kuipers, PJ; Okonkwo, GC; Schrier, DJ; Wright, CD | 1 |
| Chytyroglou-Ladas, A; Marakos, P; Papakonstantinou-Garoufalias, S; Tsantili-Kakoulidou, A | 1 |
| Schönafinger, K | 1 |
| Borg, S; Labarre, M; Luthman, K; Payza, K; Terenius, L; Vollinga, RC | 1 |
| Gonsalves, R; Holla, BS; Shenoy, S | 1 |
| Altinok, G; Demirdamar, R; Kelicen, P; Palaska, E; Sahin, G | 1 |
| Fenoy, FJ; López, B; Moreno, C; Roman, RJ; Salom, MG | 1 |
| Ahmad, R; Akhtar, H; Duddeck, H; Iqbal, R; Sitkowski, J; Stefaniak, L | 1 |
| Jacobson, KL; Ott, SM; Singh, JC; Watson, EL | 1 |
| Dalvie, DK; Kalgutkar, AS; Khojasteh-Bakht, SC; O'Donnell, JP; Obach, RS | 1 |
| Bowler, AN; Ehrbar, U; Hansen, BF; Kurtzhals, P; Olesen, PH; Sørensen, AR; Ursø, B | 1 |
| FUSCO, R; MAFFII, G; TESTA, E | 1 |
| BALLONOFF, LB; FEINSTEIN, RN; SEAHOLM, JE | 1 |
| Amtul, Z; Choudhary, MI; Khan, KM; Rasheed, M; Rosanna, S; Supino, R | 1 |
| Jähnichen, S; Pertz, HH; Radtke, OA | 1 |
| Almasirad, A; Dalvandi, A; Faizi, M; Kebriaeezadeh, A; Mehrabi, N; Shafiee, A; Tabatabai, SA | 1 |
| Armstrong, JD; Balsells, J; Dimichele, L; Hansen, K; Kubryk, M; Liu, J | 1 |
| Elmedal, B; Mulvany, MJ; Simonsen, U | 1 |
| Asplund Persson, A; Bengtsson, T; Grenegård, M; Lindström, E; Whiss, PA; Zalavary, S | 1 |
| Hu, GQ; Huang, ST; Huang, WL; Xie, SQ; Xu, QJ; Zhang, HB | 1 |
| Elmedal Laursen, B; Mulvany, MJ; Simonsen, U | 1 |
| Grenegård, M; Gunnarsson, P; Lindström, E; Persson, AA | 1 |
| D'Anna, F; Frenna, V; Macaluso, G; Marullo, S; Morganti, S; Pace, V; Spinelli, D; Spisani, R; Tavani, C | 1 |
| Kamikawa, Y; Kojima, S; Ohno, Y; Sasaki, K; Sunagawa, M; Uchida, K | 1 |
| D'Anna, F; Frenna, V; Noto, R; Pace, V; Spinelli, D | 1 |
| Hu, GQ; Huang, WL; Li, S; Sun, MF; Zhang, HB | 1 |
| de Melo, SJ; dos Anjos, JV; Sinou, D; Srivastava, RM | 1 |
| Deepti, D; Padmavathi, V; Sudhakar Reddy, G; Thriveni, P | 1 |
| Amir, M; Javed, SA; Kumar, H | 1 |
| Chhibber, M; Gupta, S; Sinha, S; Surolia, A | 1 |
| Cacic, F; Cacic, M; Has-Schon, E; Trkovnik, M | 1 |
| Cansiz, A; Cetin, A; Koparir, M | 1 |
| Al-Bayati, RH; Aouad, M; Rezki, N; Sharba, AH | 1 |
| Gadaginamath, GS; Joshi, SD; Vagdevi, HM; Vaidya, VP | 1 |
| Almajan, GL; Barbuceanu, SF; Innocenti, A; Scozzafava, A; Supuran, CT | 1 |
| Amir, M; Javed, SA; Khan, SA; Kumar, H | 1 |
| Nagendra Mohan, AV; Padmavathi, V; Shazia, A; Thriveni, P | 1 |
| Chen, CN; Chen, Q; Liu, ZM; Tu, HY; Yang, GF | 1 |
| Kondaiah, P; Padmaja, A; Padmavathi, V; Sudhakar Reddy, G | 1 |
| Ahsan, W; Alam, MS; Siddiqui, N | 1 |
| Keshavarz, MH; Shokrolahi, A; Zali, A | 1 |
| Chen, F; Lee, DY; Liu-Chen, LY; Ma, Z; Xu, W; Yang, L | 1 |
| Allen, SH; Foster, SA; Garvey, EP; Jeffrey, JL; Johns, BA; Miller, WH; Thompson, JB; Weatherhead, JG | 2 |
| de Melo, SJ; do Nascimento, SC; dos Anjos, JV; Neves Filho, RA; Sinou, D; Srivastava, RM | 1 |
| Dawson, MI; Ye, M | 1 |
| Nagawade, RR; Sangshetti, JN; Shinde, DB | 1 |
| Hirano, K; Kawano, T; Miura, M; Satoh, T; Yoshizumi, T | 1 |
| Bayrak, H; Demirbas, A; Demirbas, N; Karaoglu, SA | 1 |
| Al-Omar, MA | 1 |
| Chandrashekar, SM; Kistayya, C; Mallikarjuna, BP; Rajendraprasad, Y; Suresh Kumar, GV | 1 |
| Bibian, M; Blayo, AL; El Habnouni, S; Fehrentz, JA; Martinez, J; Moulin, A | 1 |
| Akhtar, T; Choudhary, MI; Hameed, S; Khan, A; Khan, KM | 1 |
| Gadakh, S; Gill, C; Mhaske, G; Shelke, S | 1 |
| Dembinski, JL; Dinh, H; Gradl, D; Krauss, S; Lundenes, E; Machon, O; Machonova, O; Paulsen, JE; von Kries, JP; Waaler, J; Wedlich, D; Wilson, SR | 1 |
| Sangshetti, JN; Shinde, DB | 1 |
| Mayur, CY; Prasad, VV; Purohit, M | 1 |
| Charavgi, MD; Chrysina, ED; Czecze, L; Docsa, T; Gergely, P; Kun, S; Nagy, GZ; Patonay, T; Skourti, PV; Somsák, L; Tóth, M; Van Nhien, AN | 1 |
| Dong, ZQ; Liu, FM; Xu, F; Yuan, ZL | 1 |
| Girija, D; Joy Hoskeri, H; Naik, HS; Sharath, N; Sudeep, HV; Vinay Kumar, B | 1 |
| Dürüst, Y; Kaiser, M; Karakuş, H; Tasdemir, D | 1 |
| Blank, J; Charlat, O; Cheng, H; Cheung, A; Chin, DN; Cong, F; Feng, Y; Fortin, PD; Hood, T; Kirby, CA; Shao, W; Shultz, MD; Stams, T; Tyagi, V; Xu, M; Zhang, B | 1 |
| Camoutsis, Ch; Glamočlija, J; Pairas, G; Pitsas, A; Potamitis, C; Soković, M; Zoumpoulakis, P | 1 |
| Alam, MM; Alam, MS; Haider, S; Hamid, H; Nazreen, S; Shaharyar, M | 1 |
| Aota, M; Doihara, H; Harada, K; Matsuoka, N; Morita, M; Nakato, K; Ni, K; Saita, K; Sato, Y; Takahashi, S; Yamaji, T; Yamazaki, M; Yarimizu, J | 1 |
| Belavagi, NS; Gong, YD; Kalashetti, MB; Khan, AY; Khazi, IA; Mohammed Iqbal, AK | 1 |
| Husain, A; Kumar, D; Mishra, R; Parveen, S; Rashid, M; Shin, DS | 1 |
| Akinfieva, OV; Artem'eva, MM; Daliger, IL; Medvedev, OS; Medvedeva, NA; Postnikov, AB; Shevelev, SA | 1 |
| Alliston, KR; Aravapalli, S; Dou, D; Eichhorn, DM; Groutas, WC; Lai, H; Lushington, GH; Mwania, TM; Padmanabhan, R; Teramoto, T | 1 |
| Dobish, MC; Johnston, JN; Lepesheva, GI; Villalta, F; Waterman, MR | 1 |
| DeRuyter, B; Guo, Z; Holstein, M; Lu, Y; Rabinovitch, A | 1 |
| Afzal Azam, M; Dhanabal, P; Elango, K; Jubie, S; Kalirajan, R; Muruganantham, N | 1 |
| He, LQ; Jiang, AQ; Liu, ZJ; Luo, Y; Yang, YH; Zhang, S; Zhu, HL | 1 |
| Chen, X; Li, S; Lv, Q; Tu, G; Wang, J; Yan, Y | 1 |
| Aiub, CA; Araújo, JS; Batista, Dda G; Batista, MM; Britto, C; da Silva, CF; da Silva, PB; de Souza, EM; Hargrove, TY; Kim, K; Lepesheva, GI; Lionel, J; Pavão, BP; Soeiro, Mde N; Sulikowski, G; Waterman, MR | 1 |
| Castro, R; Daffinrud, J; Krauss, S; Munthe, E; Myklebost, O; Stratford, EW; Waaler, J | 1 |
| Ahmadi, F; Banafshe, HR; Mahmoodi, B; Mashayekh, S; Motaharian, D; Navidpour, L; Rahmanipour, N; Shafaroodi, H; Shafiee, A; Shahhosseini, S | 1 |
| Lei, Z; Mao, G; Wang, J; Wen, Y; Xu, H | 1 |
| Apseloff, G; Atiee, G; Bush, MA; Collins, DA; Corsino, L; Feldman, PL; Gillmor, D; McMullen, SL; Morrow, L; Nunez, DJ | 1 |
| Abd El-Dayem, NS; El Sadek, MM; Hassan, SY; Mostafa, MA; Yacout, GA | 1 |
| Raboisson, P; Swedberg, MD | 1 |
| Green, AL; Hsu, JH; Hubbell-Engler, B; Jones, K; Knoff, DS; Kung, AL; Ligon, KL; Maire, CL; McCauley, D; Perry, JA; Ramkissoon, LA; Ramkissoon, SH; Shacham, S | 1 |
| Bekircan, O; Menteşe, E; Ülker, S | 1 |
| Cheng, H; Chisca, S; Chung, TS; Duong, PH; Hong, PY; Nunes, SP | 1 |
| Qin, L; Zard, SZ | 1 |
| Bantu, R; Gurrala, S; Jain, N; Nagarapu, L; Polepalli, S; Srujana, G; Yadagiri, B | 1 |
| Baxter, C; Edgar, DM; Gilmour, G; Kellett, DO; Loomis, S; McCarthy, A; Tricklebank, M | 1 |
| Kamel, MM; Megally Abdo, NY | 1 |
| Cominetti, D; De Cesare, M; Deraco, M; Doldi, V; Friedlander, S; Gandellini, P; Kauffman, MG; Landesman, Y; Lopergolo, A; Pennati, M; Shacham, S; Zaffaroni, N | 1 |
| Al-Blewi, FF; Al-Yahyawi, AM; Aouad, MR; Bardaweel, SK; Rezki, N | 1 |
| Festuccia, C; Gravina, GL; Kauffman, M; Landesman, Y; Mancini, A; Marampon, F; McCauley, D; Sanita, P; Shacham, S; Ventura, L; Vitale, F | 1 |
| Bai, CG; Chen, Y; Chu, XQ; Ding, YH; Li, HY; Li, YT; Meng, FF; Pan, CW; Qu, WZ; Wang, JH; Yang, C; Zhang, Q | 1 |
| Fukushima, T; Ichiba, H; Iizuka, H; Kuwabara, R; Miyagi, A; Naito, Y; Onozato, M; Sakamoto, T; Takahashi, S | 1 |
| Cui, W; Hu, H; Liu, B; Liu, D; Xie, R; Zuo, Y | 1 |
| Aboukameel, A; Azmi, AS; Baloglu, E; Bhutani, D; Carlson, R; Elloul, S; Kauffman, M; Mohammad, RM; Muqbil, I; Senapedis, W; Shacham, S; Zonder, J | 1 |
| Joshi, RA; Joshi, RR; Likhite, AP; Nawale, L; Rode, ND; Sarkar, D; Sonawane, AD | 1 |
| Collu, D; Iuliano, F; Jóźwiak, M; Kozioł, AE; Lis, T; Struga, M; Szulczyk, D; Tomaszewski, P | 1 |
| Bektaş, H; Çakır, D; Emirik, M; Kahveci, B; Menteşe, E; Sokmen, BB | 1 |
| Doshi, H; Ray, A; Thakkar, SS; Thakor, P | 1 |
| Boland, BS; Vermeire, S | 1 |
| Cantürk, Z; Çavuşoğlu, BK; Yurttaş, L | 1 |
| Madhu Sekhar, M; Nagarjuna, U; Padmaja, A; Padmavathi, V; Reddy, NV; Vijaya, T | 1 |
| Dilmaghani, KA; Tukmechi, A; Ziaie, M | 1 |
| Bai, CG; Chen, Y; He, DD; Li, HY; Sun, TY; Zhang, Q; Zhao, XJ | 1 |
| Elseginy, SA; Hamdy, R; Jones, AT; Westwell, AD; Ziedan, NI | 1 |
| Bolli, MH; Boss, C; Brotschi, C; Gatfield, J; Heidmann, B; Jenck, F; Roch, C; Sifferlen, T; Treiber, A; Williams, JT | 2 |
| Battat, R; Dulai, PS; Feagan, BG; Jairath, V; Ma, C; Parker, CE; Sandborn, WJ | 1 |
| Baev, DS; Frolova, TS; Popov, SA; Semenova, MD; Shults, EE; Turks, M; Wang, C | 1 |
| Allocca, M; Correale, C; Danese, S; Fiorino, G; Furfaro, F; Gabbiadini, R; Gilardi, D; Peyrin-Biroulet, L; Zilli, A | 1 |
| Baev, DS; Frolova, TS; Popov, SA; Qi, Z; Semenova, MD; Shestopalov, MA; Shults, EE; Turks, M; Wang, C | 1 |
| Aly, AA; Bräse, S; El-Haleem, LEA; Hassan, AA; Mohamed, NK; Nieger, M | 1 |
| Bansode, MU; Doshi, GM; Somani, RR | 1 |
| Jain, A; Piplani, P | 1 |
| Kaneko, D; Koketsu, M; Ninomiya, M; Nishina, A; Ono, Y; Sonawane, AD; Tanaka, K; Yoshikawa, R | 1 |
| Archana, A | 1 |
| Abdel-Aziz, SA; Aboraia, AS; El-Koussi, NA; Gomaa, HAM; Hofny, HA; Mohamed, MFA; Youssif, BGM | 1 |
| Araújo, HM; Flávia do Amaral Moura, C; Gonçalves Ferreira, VP; Lapa Montenegro Pimentel, LM; Melo de Oliveira, VN; Nascimento de Oliveira, R; Nicolete, R; Peixoto, ADS; Pena, LJ; Pessoa, CDÓ; Rathi, B; Rollin, P; Sharma, PP; Tatibouët, A; Versiani Dos Anjos, J | 1 |
| Ben Hamida, S; Darcq, E; Decker, AM; Jin, C; Kieffer, BL; Laudermilk, L; Ma, W; Maitra, R; Rahman, MT | 1 |
| Faiz, S; Irfan, A; Kotwica-Mojzych, K; Mojzych, M; Rasul, A; Zafar, R; Zahoor, AF | 1 |
| Gomaa, HAM; Mahmoud, MA; Mohammed, AF; Salem, OIA; Youssif, BGM | 1 |
| A A Abd El-Wahab, H; Abdel-Fattah, HA; E A Hassan, A; Ghanim, AM; Hamoud, MMS; Osman, NA; Rezq, S; Romero, DG | 1 |
| Emami, S; Hashemi, SM; Hosseini-Khah, Z; Mahmoudi, F | 1 |
7 review(s) available for triazoles and oxadiazoles
| Article | Year |
|---|---|
The chemistry and biochemistry of C-nucleosides.
Topics: Animals; Anti-Bacterial Agents; Benzimidazoles; Chemical Phenomena; Chemistry; Formycins; Imidazoles; Isoxazoles; Nucleosides; Oxadiazoles; Pseudouridine; Purine Nucleosides; Pyrazoles; Showdomycin; Thiazoles; Triazoles; Uridine | 1976 |
Heterocyclic NO prodrugs.
Topics: Animals; Humans; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Structure-Activity Relationship; Triazoles | 1999 |
Biotransformation reactions of five-membered aromatic heterocyclic rings.
Topics: Animals; Cytochrome P-450 Enzyme System; Furans; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Indoles; Isoxazoles; Models, Chemical; Molecular Structure; Oxadiazoles; Oxazoles; Pyrazoles; Pyrroles; Tetrazoles; Thiadiazoles; Thiazoles; Thiophenes; Triazoles; Xenobiotics | 2002 |
Synthesis of 3,4,5-trisubstituted-1,2,4-triazoles.
Topics: Amides; Hydrazones; Oxadiazoles; Oxazolone; Quinazolines; Thioamides; Triazoles | 2010 |
Janus Kinase Antagonists and Other Novel Small Molecules for the Treatment of Crohn's Disease.
Topics: B-Lymphocytes; Colitis, Ulcerative; Crohn Disease; Humans; Indans; Janus Kinase 1; Janus Kinase Inhibitors; Oligonucleotides; Oxadiazoles; Piperidines; Pyridines; Pyrimidines; Pyrroles; Receptors, Lysosphingolipid; Smad7 Protein; T-Lymphocytes; Triazoles | 2017 |
Innovations in Oral Therapies for Inflammatory Bowel Disease.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug Discovery; Heterocyclic Compounds, 3-Ring; Humans; Indans; Inflammatory Bowel Diseases; Janus Kinase Inhibitors; Mesalamine; Oxadiazoles; Phosphodiesterase Inhibitors; Piperidines; Pyridines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Receptors, Lysosphingolipid; Triazoles | 2019 |
PK, PD, and interactions: the new scenario with JAK inhibitors and S1P receptor modulators, two classes of small molecule drugs, in IBD.
Topics: Acetates; Animals; Clinical Trials as Topic; Colitis, Ulcerative; Crohn Disease; Heterocyclic Compounds, 3-Ring; Humans; Indans; Indoles; Janus Kinase Inhibitors; Oxadiazoles; Piperidines; Pyridines; Pyrimidines; Quinolones; Sphingosine-1-Phosphate Receptors; Triazoles | 2020 |
1 trial(s) available for triazoles and oxadiazoles
| Article | Year |
|---|---|
Gut hormone pharmacology of a novel GPR119 agonist (GSK1292263), metformin, and sitagliptin in type 2 diabetes mellitus: results from two randomized studies.
Topics: Blood Glucose; C-Peptide; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Male; Mesylates; Metformin; Middle Aged; Oxadiazoles; Peptide YY; Prognosis; Pyrazines; Receptors, G-Protein-Coupled; Sitagliptin Phosphate; Triazoles | 2014 |
127 other study(ies) available for triazoles and oxadiazoles
| Article | Year |
|---|---|
[Reactions of potassium salts and methyl esters of some aroylhydrazino-carbodithioic acids].
Topics: Crystallization; Hydrazines; Methylation; Oxadiazoles; Potassium; Thiadiazines; Thiadiazoles; Triazoles | 1978 |
Anticoccidials. I. Syntheses and anticoccidial activity of 2-amino-5-aryl-1,3,4-oxadiazoles, 5-alkoxy-3-aryl-1H-1,2,4-triazoles, and 3-aryl-delta2-1,2,4-triazolin-5-ones.
Topics: Animals; Chickens; Coccidiosis; Coccidiostats; Male; Oxadiazoles; Triazoles | 1976 |
Benzo[b]thiophenes, Part I: Synthesis and antimicrobial activity of benzo[b]thienyl-1,3,4-oxadiazole, -1,2,4-triazoline, and -thiazoline derivatives.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Candida albicans; Microbial Sensitivity Tests; Oxadiazoles; Thiazoles; Thiophenes; Triazoles | 1992 |
[Synthesis and anticonvulsive activity of some new bisubstituted 1,3,4-oxadiazoles and 1H-1,2,4-triazoles].
Topics: Animals; Anticonvulsants; Male; Mice; Oxadiazoles; Triazoles | 1989 |
The action of natural and synthetic isomers of quisqualic acid at a well-defined glutamatergic synapse.
Topics: Animals; Glutamates; Grasshoppers; Imidazoles; In Vitro Techniques; Neuromuscular Junction; Oxadiazoles; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Structure-Activity Relationship; Synaptic Transmission; Triazoles; X-Ray Diffraction | 1986 |
Pregnancy interceptive activity of triazoles, oxadiazoles & thiadiazoles.
Topics: Animals; Cricetinae; Female; Mesocricetus; Oxadiazoles; Pregnancy; Pregnancy, Animal; Thiadiazoles; Triazoles | 1987 |
Synthesis of 5-membered heterocycles and related compounds.
Topics: Antifungal Agents; Aspergillus niger; Methods; Oxadiazoles; Seeds; Thiosemicarbazones; Triazoles | 1974 |
[Formation of heterocyclic derivatives from (2- or 3-methyl-phenothiazinyl-(10))-propionic acid. 17. Phenothiazine derivatives].
Topics: Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Heterocyclic Compounds; Hydrazines; Oxadiazoles; Phenothiazines; Propionates; Semicarbazides; Thiadiazoles; Triazoles | 1972 |
Synthesis and antimicrobial testing of certain oxadiazoline and triazole derivatives.
Topics: Anti-Bacterial Agents; Bacteria; Chemical Phenomena; Chemistry; Oxadiazoles; Triazoles | 1983 |
Preparation of C-(2-deoxyhex/pent-1-enopyranosyl)heterocycles.
Topics: Cyanides; Glycosides; Indicators and Reagents; Magnetic Resonance Spectroscopy; Molecular Structure; Nucleosides; Optical Rotation; Oxadiazoles; Solvents; Stereoisomerism; Thiazoles; Triazoles | 1994 |
Design of 5-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3,4-thiadiazoles, -1,3,4-oxadiazoles, and -1,2,4-triazoles as orally-active, nonulcerogenic antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Imidazoles; Lipoxygenase Inhibitors; Male; Oxadiazoles; Rats; Rats, Wistar; Thiadiazoles; Triazoles | 1993 |
1,3,4-Oxadiazole, 1,3,4-thiadiazole, and 1,2,4-triazole analogs of the fenamates: in vitro inhibition of cyclooxygenase and 5-lipoxygenase activities.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Edema; In Vitro Techniques; Lipoxygenase Inhibitors; Male; ortho-Aminobenzoates; Oxadiazoles; Rats; Rats, Wistar; Structure-Activity Relationship; Thiadiazoles; Triazoles; Tumor Cells, Cultured | 1993 |
Synthesis, lipophilicity and antimicrobial properties of some O-(5-aryl-1,2,4-triazol-3-yl-ethyl)benzaldoximes and O-(5-aryl-1,3,4-oxydiazol-2-yl-ethyl)benzaldoximes.
Topics: Anti-Bacterial Agents; Bacteria; Chemical Phenomena; Chemistry, Physical; Lipids; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Oxadiazoles; Oximes; Solubility; Triazoles | 1998 |
Design, synthesis, and evaluation of Phe-Gly mimetics: heterocyclic building blocks for pseudopeptides.
Topics: Animals; Brain; Cell Line; Dipeptides; Drug Design; Humans; In Vitro Techniques; Models, Molecular; Molecular Conformation; Molecular Mimicry; Oligopeptides; Oxadiazoles; Radioligand Assay; Rats; Receptors, Neurokinin-1; Receptors, Opioid, delta; Receptors, Opioid, mu; Triazoles | 1999 |
Synthesis and antibacterial studies of a new series of 1,2-bis(1,3, 4-oxadiazol-2-yl)ethanes and 1,2-bis(4-amino-1,2, 4-triazol-3-yl)ethanes.
Topics: Anti-Bacterial Agents; Bacteria; Indicators and Reagents; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Oxadiazoles; Spectrophotometry, Infrared; Triazoles | 2000 |
Synthesis of some new 1-acylthiosemicarbazides, 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazole-3-thiones and their anti-inflammatory activities.
Topics: Air; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azides; Carrageenan; Crystallization; Edema; Foot; Male; Mice; Oxadiazoles; Spectrophotometry, Ultraviolet; Thiadiazoles; Triazoles | 2001 |
Role of guanylyl cyclase and cytochrome P-450 on renal response to nitric oxide.
Topics: Acetylcysteine; Amidines; Animals; Blood Pressure; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glomerular Filtration Rate; Guanylate Cyclase; Infusions, Parenteral; Kidney; Male; Methylene Blue; Natriuresis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Rats; Rats, Sprague-Dawley; Renal Circulation; Triazoles | 2001 |
Synthesis and structure determination of some oxadiazole-2-thione and triazole-3-thione galactosides.
Topics: Chromatography, Thin Layer; Galactosides; Magnetic Resonance Spectroscopy; Mass Spectrometry; Oxadiazoles; Spectrophotometry, Infrared; Thiones; Triazoles | 2001 |
Nitric oxide inhibition of cAMP synthesis in parotid acini: regulation of type 5/6 adenylyl cyclase.
Topics: Adenylyl Cyclases; Animals; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Isoenzymes; Isoproterenol; Mice; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Parotid Gland; Phosphoric Diester Hydrolases; Quinoxalines; Thapsigargin; Triazoles | 2001 |
Synthesis and in vitro characterization of 1-(4-aminofurazan-3-yl)-5-dialkylaminomethyl-1H-[1,2,3]triazole-4-carboxylic acid derivatives. A new class of selective GSK-3 inhibitors.
Topics: Animals; beta Catenin; CHO Cells; Cricetinae; Cytoskeletal Proteins; Databases, Factual; Enzyme Inhibitors; Glycogen; Glycogen Synthase Kinase 3; Humans; In Vitro Techniques; Male; Muscle, Skeletal; Oxadiazoles; Rats; Rats, Wistar; Solubility; Structure-Activity Relationship; Trans-Activators; Triazoles; Water | 2003 |
[Pharmacological study of several oxadiazoles & triazoles].
Topics: Azoles; Oxadiazoles; Triazoles | 1958 |
EFFECT ON CATALASE IN VIVO AND IN VITRO OF COMPOUNDS RELATED TO AMINOTRIAZOLE. ANL-6823.
Topics: Amitrole; Azides; Azoles; Catalase; Enzyme Inhibitors; Erythrocytes; Imidazoles; In Vitro Techniques; Isoniazid; Kidney; Liver; Oxadiazoles; Oxazoles; Oxidation-Reduction; Pentylenetetrazole; Pharmacology; Pyrazoles; Rats; Research; Thiazoles; Triazoles | 1964 |
Kinetics of novel competitive inhibitors of urease enzymes by a focused library of oxadiazoles/thiadiazoles and triazoles.
Topics: Animals; Anti-Bacterial Agents; Drug Design; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Microbial Sensitivity Tests; Molecular Structure; Oxadiazoles; Thiadiazoles; Triazoles; Urease | 2004 |
Involvement of 5-HT1B receptors in triptan-induced contractile responses in guinea-pig isolated iliac artery.
Topics: Animals; Benzamides; Brain; Carbazoles; Dinoprost; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Endothelium, Vascular; Female; Forecasting; Guinea Pigs; Iliac Artery; Indoles; Ketanserin; Male; Muscle Contraction; Muscle, Smooth; Oxadiazoles; Oxazolidinones; Piperazines; Piperidines; Pyrrolidines; Receptor, Serotonin, 5-HT1B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serotonin; Serotonin 5-HT1 Receptor Antagonists; Sumatriptan; Triazoles; Tryptamines | 2004 |
Synthesis and anticonvulsant activity of new 2-substituted-5- [2-(2-fluorophenoxy)phenyl]-1,3,4-oxadiazoles and 1,2,4-triazoles.
Topics: Anticonvulsants; Drug Evaluation, Preclinical; Molecular Structure; Oxadiazoles; Structure-Activity Relationship; Triazoles | 2004 |
Synthesis of [1,2,4]triazolo[4,3-alpha]piperazines via highly reactive chloromethyloxadiazoles.
Topics: Catalysis; Ethylenediamines; Magnetic Resonance Spectroscopy; Molecular Structure; Oxadiazoles; Oxidation-Reduction; Piperazines; Stereoisomerism; Triazoles | 2005 |
Dual impact of a nitric oxide donor, GEA 3175, in human pulmonary smooth muscle.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Albuterol; Bronchi; Bronchodilator Agents; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Peptides; Pulmonary Artery; Quinoxalines; Triazoles; Vasoconstrictor Agents; Vasodilation | 2005 |
Cross-talk between adenosine and the oxatriazole derivative GEA 3175 in platelets.
Topics: Adenosine; Blood Platelets; Calcium; Cyclic AMP; Cyclic GMP; Cytosol; Drug Interactions; Enzyme Inhibitors; Guanylate Cyclase; Humans; Milrinone; Oxadiazoles; Phosphodiesterase Inhibitors; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinoxalines; Thrombin; Time Factors; Triazoles | 2005 |
[Synthesis and antibacterial activity of 3-(5-substituted phenyl-[1,3,4] oxadiazole-2-yl-methylenethio)-5-pyridin-3-yl-[1,2,4] triazole-4-yl-amines].
Topics: Anti-Bacterial Agents; Escherichia coli; Oxadiazoles; Proteus vulgaris; Staphylococcus aureus; Triazoles | 2005 |
Involvement of guanylyl cyclase, protein kinase A and Na+ K+ ATPase in relaxations of bovine isolated bronchioles induced by GEA 3175, an NO donor.
Topics: Animals; Bronchi; Calcium; Cattle; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Guanylate Cyclase; In Vitro Techniques; Molsidomine; Muscle Relaxation; Nitric Oxide; Nitric Oxide Donors; Ouabain; Oxadiazoles; Peptides; Potassium; Quinoxalines; S-Nitrosoglutathione; Serotonin; Sodium-Potassium-Exchanging ATPase; Thionucleotides; Triazoles | 2006 |
Dual actions of dephostatin on the nitric oxide/cGMP-signalling pathway in porcine iliac arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Blotting, Western; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Hydroquinones; Iliac Artery; In Vitro Techniques; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Phenylephrine; Phosphoproteins; Phosphorylation; Protein Tyrosine Phosphatases; Quinoxalines; Serine; Signal Transduction; Swine; Triazoles; Tyrosine; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2005 |
On the rearrangement in dioxane/water of (Z)-arylhydrazones of 5-amino-3-benzoyl-1,2,4-oxadiazole into (2-aryl-5-phenyl-2H-1,2,3-triazol-4-yl)ureas: substituent effects on the different reaction pathways.
Topics: Catalysis; Dioxanes; Hydrazones; Kinetics; Molecular Structure; Oxadiazoles; Thermodynamics; Triazoles; Water | 2006 |
The suppressant effect of GEA3162 on spontaneous serotonin release from human colonic mucosa in vitro.
Topics: Calcium Channel Blockers; Chromatography, High Pressure Liquid; Colon; Electrochemistry; Enzyme Inhibitors; Gastrointestinal Hormones; Guanylate Cyclase; Hydroxyindoleacetic Acid; Intestinal Mucosa; Natriuretic Peptides; NG-Nitroarginine Methyl Ester; Nicardipine; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Peroxynitrous Acid; Quinoxalines; Serotonin; Triazoles | 2006 |
Room temperature ionic liquids structure and its effect on the mononuclear rearrangement of heterocycles: an approach using thermodynamic parameters.
Topics: Amines; Heterocyclic Compounds; Hydrazones; Ionic Liquids; Molecular Structure; Oxadiazoles; Temperature; Thermodynamics; Triazoles | 2006 |
[Synthesis and antibacterial activity of 3-(4-amino-5-methyl-s-triazol-3-sulfanyl)-1-phenyl-propan-1-one O-(5-substituted phenyl-[1,3,4] oxadiazol-2-methyl)-oximes].
Topics: Anti-Bacterial Agents; Oxadiazoles; Oximes; Triazoles | 2006 |
Synthesis of glycosyl-triazole linked 1,2,4-oxadiazoles.
Topics: Glycosylation; Magnetic Resonance Spectroscopy; Molecular Structure; Oxadiazoles; Triazoles | 2007 |
Synthesis and antimicrobial activity of novel sulfone-linked bis heterocycles.
Topics: Anti-Bacterial Agents; Antifungal Agents; Microbial Sensitivity Tests; Oxadiazoles; Pyrazoles; Structure-Activity Relationship; Sulfones; Thiadiazoles; Triazoles | 2008 |
Non-carboxylic analogues of naproxen: design, synthesis, and pharmacological evaluation of some 1,3,4-oxadiazole/thiadiazole and 1,2,4-triazole derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Drug Design; Edema; Liver; Liver Function Tests; Male; Mice; Molecular Structure; Naproxen; Oxadiazoles; Pain; Rats; Stomach Ulcer; Thiadiazoles; Triazoles | 2007 |
Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates.
Topics: Amyloidosis; Benzamides; Benzothiazoles; Cell Line; Cell Survival; Cross-Linking Reagents; Drug Design; Fluorescence; Glutaral; Humans; Kinetics; Models, Molecular; Oxadiazoles; Phenyl Ethers; Prealbumin; Protein Denaturation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Structure-Activity Relationship; Thiazoles; Triazoles; Tryptophan | 2007 |
Synthesis and antimicrobial activity of some derivatives of (7-hydroxy-2-oxo-2H-chromen-4-yl)-acetic acid hydrazide.
Topics: Acetates; Anti-Bacterial Agents; Coumarins; Gram-Negative Bacteria; Gram-Positive Bacteria; Hydrazines; Microbial Sensitivity Tests; Oxadiazoles; Triazoles | 2006 |
5-Furan-2yl[1,3,4]oxadiazole-2-thiol, 5-furan-2yl-4H [1,2,4] triazole-3-thiol and their thiol-thione tautomerism.
Topics: Furans; Isomerism; Models, Biological; Oxadiazoles; Pyridazines; Sulfhydryl Compounds; Thiones; Triazoles | 2005 |
Synthesis of oxadiazoles, thiadiazoles and triazoles derived from benzo[b]thiophene.
Topics: Oxadiazoles; Thiadiazoles; Thiophenes; Triazoles | 2005 |
Synthesis of new 4-pyrrol-1-yl benzoic acid hydrazide analogs and some derived oxadiazole, triazole and pyrrole ring systems: a novel class of potential antibacterial and antitubercular agents.
Topics: Anti-Bacterial Agents; Antitubercular Agents; Benzoic Acid; Drug Design; Mycobacterium tuberculosis; Oxadiazoles; Pyrroles; Triazoles | 2008 |
Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II and IX with some 1,3,4-oxadiazole- and 1,2,4-triazole-thiols.
Topics: Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase III; Carbonic Anhydrase Inhibitors; Kinetics; Oxadiazoles; Structure-Activity Relationship; Sulfhydryl Compounds; Triazoles | 2008 |
1,3,4-Oxadiazole/thiadiazole and 1,2,4-triazole derivatives of biphenyl-4-yloxy acetic acid: synthesis and preliminary evaluation of biological properties.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Carrageenan; Diphenylacetic Acids; Drug Evaluation, Preclinical; Edema; Female; Gastric Mucosa; Lipid Peroxidation; Liver; Male; Mice; Molecular Structure; Oxadiazoles; Rats; Rats, Wistar; Stereoisomerism; Stomach Ulcer; Thiadiazoles; Triazoles | 2008 |
Synthesis and bioassay of a new class of heterocycles pyrrolyl oxadiazoles/thiadiazoles/triazoles.
Topics: Anti-Infective Agents; Antineoplastic Agents; Drug Screening Assays, Antitumor; Heterocyclic Compounds; Humans; Microbial Sensitivity Tests; Oxadiazoles; Structure-Activity Relationship; Thiadiazoles; Triazoles | 2009 |
Syntheses of diheterocyclic compounds based on 2-thioacetohydrazide-5,7-dimethyl-1,2,4-triazolo[1,5-a]- pyrimidine.
Topics: Heterocyclic Compounds; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Oxadiazoles; Pyrimidines; Thiadiazoles; Triazoles | 2008 |
Synthesis, antimicrobial and cytotoxic activities of 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles.
Topics: Anti-Infective Agents; Heterocyclic Compounds; Microbial Sensitivity Tests; Oxadiazoles; Thiadiazoles; Triazoles | 2009 |
Synthesis, anticonvulsant and toxicity evaluation of 2-(1H-indol-3-yl)acetyl-N-(substituted phenyl)hydrazine carbothioamides and their related heterocyclic derivatives.
Topics: Animals; Anticonvulsants; Female; Hydrazines; Male; Mice; Oxadiazoles; Structure-Activity Relationship; Thiadiazoles; Triazoles | 2008 |
A simple approach for predicting impact sensitivity of polynitroheteroarenes.
Topics: Explosions; Explosive Agents; Heterocyclic Compounds, 1-Ring; Materials Testing; Models, Theoretical; Neural Networks, Computer; Nitro Compounds; Nitrofurans; Nitroimidazoles; Oxadiazoles; Pyrazoles; Pyridines; Pyrimidines; Structure-Activity Relationship; Triazoles | 2009 |
Synthesis and biological evaluation of C-12 triazole and oxadiazole analogs of salvinorin A.
Topics: Animals; Carbon; CHO Cells; Cricetinae; Cricetulus; Diterpenes, Clerodane; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Mice; Oxadiazoles; Protein Binding; Rats; Structure-Activity Relationship; Triazoles | 2009 |
1,3,4-Oxadiazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 2: SAR of the C5 position.
Topics: Amino Acid Motifs; Anti-HIV Agents; Chelating Agents; Chemistry, Pharmaceutical; Drug Design; HIV Infections; HIV Integrase Inhibitors; Humans; Metals; Models, Chemical; Molecular Structure; Naphthyridines; Oxadiazoles; Structure-Activity Relationship; Triazoles | 2009 |
The use of oxadiazole and triazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 1: Establishing the pharmacophore.
Topics: Amino Acid Motifs; Anti-HIV Agents; Chelating Agents; Chemistry, Pharmaceutical; Drug Design; HIV Infections; HIV Integrase Inhibitors; Humans; Models, Chemical; Molecular Structure; Naphthyridines; Oxadiazoles; Structure-Activity Relationship; Triazoles; Virus Replication | 2009 |
Synthesis and cytotoxic profile of glycosyl-triazole linked to 1,2,4-oxadiazole moiety at C-5 through a straight-chain carbon and oxygen atoms.
Topics: Antineoplastic Agents; Carbon; Carcinoma; Cell Line, Tumor; Cell Proliferation; Glycosylation; Humans; Laryngeal Neoplasms; Lung Neoplasms; Oxadiazoles; Oxygen; Triazoles | 2009 |
Studies of cannabinoid-1 receptor antagonists for the treatment of obesity: hologram QSAR model for biarylpyrazolyl oxadiazole ligands.
Topics: Cyclopropanes; Drug Design; Ligands; Obesity; Oxadiazoles; Quantitative Structure-Activity Relationship; Receptor, Cannabinoid, CB1; Triazoles | 2009 |
Synthesis of novel 3-(1-(1-substituted piperidin-4-yl)-1H-1,2,3-triazol-4-yl)-1,2,4-oxadiazol-5(4H)-one as antifungal agents.
Topics: Antifungal Agents; Fluconazole; Miconazole; Microbial Sensitivity Tests; Oxadiazoles; Structure-Activity Relationship; Triazoles | 2009 |
Copper-mediated direct arylation of 1,3,4-oxadiazoles and 1,2,4-triazoles with aryl iodides.
Topics: Catalysis; Copper; Hydrocarbons, Iodinated; Molecular Structure; Oxadiazoles; Triazoles | 2009 |
Synthesis of some new 1,2,4-triazoles starting from isonicotinic acid hydrazide and evaluation of their antimicrobial activities.
Topics: Anti-Infective Agents; Bacteria; Isoniazid; Mannich Bases; Microbial Sensitivity Tests; Molecular Structure; Oxadiazoles; Structure-Activity Relationship; Triazoles; Yeasts | 2009 |
Synthesis and antimicrobial activity of new 5-(2-thienyl)-1,2,4-triazoles and 5-(2-thienyl)-1,3,4-oxadiazoles and related derivatives.
Topics: Anti-Infective Agents; Bacteria; Crystallization; Fungi; Microbial Sensitivity Tests; Molecular Weight; Oxadiazoles; Solvents; Triazoles | 2010 |
Synthesis of some novel 2-substituted-5-[isopropylthiazole] clubbed 1,2,4-triazole and 1,3,4-oxadiazoles as potential antimicrobial and antitubercular agents.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Antitubercular Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Oxadiazoles; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Triazoles | 2010 |
Design, synthesis, and urease inhibition studies of some 1,3,4-oxadiazoles and 1,2,4-triazoles derived from mandelic acid.
Topics: Anti-Ulcer Agents; Drug Design; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Mandelic Acids; Oxadiazoles; Structure-Activity Relationship; Triazoles; Urease | 2010 |
Green synthesis and biological evaluation of some novel azoles as antimicrobial agents.
Topics: Anti-Infective Agents; Azoles; Microbial Sensitivity Tests; Microwaves; Oxadiazoles; Semicarbazides; Thiadiazoles; Triazoles; Ultrasonics | 2010 |
Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth.
Topics: Animals; Cell Division; Cell Line, Tumor; Colorectal Neoplasms; Humans; Mice; Oxadiazoles; Signal Transduction; Triazoles; Wnt Proteins | 2011 |
Synthesis of some novel 3-(1-(1-substitutedpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)-5-substituted phenyl-1,2,4-oxadiazoles as antifungal agents.
Topics: Antifungal Agents; Benzoates; Carbonates; Fungi; Imidazoles; Microbial Sensitivity Tests; Oxadiazoles; Potassium; Structure-Activity Relationship; Triazoles | 2011 |
Synthesis and cytotoxicity of bis-1,3,4-oxadiazoles and bis-pyrazoles derived from 1,4-bis[5-thio-4-substituted-1,2,4-triazol-3-yl]-butane and their DNA binding studies.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromatography, Thin Layer; DNA; Humans; Inhibitory Concentration 50; Intercalating Agents; Molecular Structure; Oxadiazoles; Spectroscopy, Fourier Transform Infrared; Triazoles | 2011 |
Synthesis of variously coupled conjugates of D-glucose, 1,3,4-oxadiazole, and 1,2,3-triazole for inhibition of glycogen phosphorylase.
Topics: Alkynes; Animals; Azides; Catalysis; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Glucose; Glycoconjugates; Glycogen Phosphorylase, Muscle Form; Humans; Kinetics; Oxadiazoles; Phosphorylase b; Propionates; Rabbits; Triazoles | 2011 |
Synthesis of 1,5-benzothiazepine derivatives bearing 2-phenoxy-quinoline moiety via 1,3-diplolar cycloaddition reaction.
Topics: Chemistry Techniques, Synthetic; Drug Design; Oxadiazoles; Quinolines; Thiazepines; Triazoles | 2011 |
Synthesis and biological evaluation of new Tetra-aza macrocyclic scaffold constrained oxadiazole, thiadiazole and triazole rings.
Topics: Anti-Bacterial Agents; Antioxidants; Bacteria; Ciprofloxacin; DNA; DNA Replication; Macrocyclic Compounds; Microbial Sensitivity Tests; Oxadiazoles; Structure-Activity Relationship; Thiadiazoles; Triazoles | 2012 |
Synthesis and anti-protozoal activity of novel dihydropyrrolo[3,4-d][1,2,3]triazoles.
Topics: Animals; Antiprotozoal Agents; Cell Line; Eukaryota; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Molecular Structure; Oxadiazoles; Protozoan Infections; Pyrroles; Rats; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Structure-Activity Relationship; Triazoles | 2012 |
[1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding.
Topics: Adenosine; Binding Sites; Crystallography, X-Ray; HEK293 Cells; Humans; Models, Molecular; Oxadiazoles; Protein Conformation; Structure-Activity Relationship; Sulfides; Tankyrases; Triazoles; Wnt Signaling Pathway | 2012 |
Synthesis of novel sulfonamide-1,2,4-triazoles, 1,3,4-thiadiazoles and 1,3,4-oxadiazoles, as potential antibacterial and antifungal agents. Biological evaluation and conformational analysis studies.
Topics: Anti-Bacterial Agents; Antifungal Agents; Bacteria; Fungi; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Oxadiazoles; Thiadiazoles; Triazoles | 2012 |
Synthesis of novel 8-hydroxy quinolin based 1,3,4-oxadiazoles and S-substituted 1,2,4-triazole derivatives and evaluation of their anti-inflammatory, analgesic, ulcerogenic and anti-microbial activities.
Topics: Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Edema; Gram-Negative Bacteria; Microbial Sensitivity Tests; Molecular Structure; Oxadiazoles; Quinolones; Rats; Rats, Wistar; Stomach Ulcer; Structure-Activity Relationship; Triazoles | 2011 |
A novel glycine transporter-1 (GlyT1) inhibitor, ASP2535 (4-[3-isopropyl-5-(6-phenyl-3-pyridyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole), improves cognition in animal models of cognitive impairment in schizophrenia and Alzheimer's disease.
Topics: Administration, Oral; Alzheimer Disease; Animals; Brain; Cognition Disorders; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Glycine Plasma Membrane Transport Proteins; Humans; Inhibitory Concentration 50; Male; Memory Disorders; Mice; Oxadiazoles; Permeability; Rats; Rats, Wistar; Schizophrenia; Triazoles | 2012 |
Synthesis, hypoglycemic and hypolipidemic activities of novel thiazolidinedione derivatives containing thiazole/triazole/oxadiazole ring.
Topics: Animals; Chemistry Techniques, Synthetic; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Hypolipidemic Agents; Male; Oxadiazoles; Rats; Rats, Wistar; Thiazoles; Thiazolidinediones; Triazoles | 2012 |
Benzimidazole bearing oxadiazole and triazolo-thiadiazoles nucleus: design and synthesis as anticancer agents.
Topics: Antineoplastic Agents; Benzimidazoles; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; Humans; Neoplasms; Oxadiazoles; Thiadiazoles; Triazoles | 2012 |
[Peripheral mechanisms of action of oxatriazolium-5-olate derivative 3-(3-[1,2,4]-triazolo)oxatriazolium-5-olate in spontaneously hypertensive rats].
Topics: Animals; Arteries; Guanylate Cyclase; Heme; Male; Nitric Oxide; Nitroprusside; Oxadiazoles; Phenylephrine; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Wistar; Tail; Tissue Culture Techniques; Triazoles; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2012 |
Design, synthesis and characterization of novel 1,2-benzisothiazol-3(2H)-one and 1,3,4-oxadiazole hybrid derivatives: potent inhibitors of Dengue and West Nile virus NS2B/NS3 proteases.
Topics: Animals; Antiviral Agents; Dengue; Dengue Virus; Drug Design; Humans; Models, Molecular; Oxadiazoles; Peptide Hydrolases; Protease Inhibitors; Triazoles; West Nile Fever; West Nile virus | 2013 |
Organocatalytic, enantioselective synthesis of VNI: a robust therapeutic development platform for Chagas, a neglected tropical disease.
Topics: Animals; Chagas Disease; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Imidazoles; Mice; Molecular Structure; Neglected Diseases; Oxadiazoles; Triazoles; Tropical Medicine; Trypanosoma cruzi | 2012 |
Stimulating β-cell regeneration by combining a GPR119 agonist with a DPP-IV inhibitor.
Topics: Acids, Heterocyclic; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Glucagon-Like Peptide 1; Humans; Insulin-Secreting Cells; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Oxadiazoles; Pyrazines; Receptors, G-Protein-Coupled; Regeneration; Sitagliptin Phosphate; Triazoles | 2013 |
Synthesis and characterization of some novel fatty acid analogues: a preliminary investigation on their activity against human lung carcinoma cell line.
Topics: Cell Line, Tumor; Cell Survival; Cytotoxins; Drug Screening Assays, Antitumor; gamma-Linolenic Acid; Humans; Magnetic Resonance Spectroscopy; Oxadiazoles; Spirulina; Stearic Acids; Triazoles | 2013 |
Synthesis, biological evaluation, and molecular docking studies of novel 1,3,4-oxadiazole derivatives possessing benzotriazole moiety as FAK inhibitors with anticancer activity.
Topics: Antineoplastic Agents; Focal Adhesion Protein-Tyrosine Kinases; HT29 Cells; Humans; MCF-7 Cells; Molecular Docking Simulation; Neoplasms; Oxadiazoles; Protein Kinase Inhibitors; Structure-Activity Relationship; Triazoles | 2013 |
Synthesis and antiproliferative assay of 1,3,4-oxadiazole and 1,2,4-triazole derivatives in cancer cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Hep G2 Cells; HT29 Cells; Humans; K562 Cells; Oxadiazoles; Structure-Activity Relationship; Triazoles | 2013 |
In vitro and in vivo studies of the antiparasitic activity of sterol 14α-demethylase (CYP51) inhibitor VNI against drug-resistant strains of Trypanosoma cruzi.
Topics: 14-alpha Demethylase Inhibitors; Animals; Chagas Disease; Drug Resistance; Endoplasmic Reticulum; Golgi Apparatus; Imidazoles; Male; Mice; Microscopy, Electron, Transmission; Nitroimidazoles; Oxadiazoles; Protozoan Proteins; Sterol 14-Demethylase; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
The tankyrase-specific inhibitor JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines.
Topics: Antineoplastic Agents; Apoptosis; Axin Signaling Complex; Bone Neoplasms; Cell Cycle; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Humans; Osteogenesis; Osteosarcoma; Oxadiazoles; Tankyrases; Triazoles; Wnt Signaling Pathway | 2014 |
Synthesis, receptor affinity and effect on pentylenetetrazole-induced seizure threshold of novel benzodiazepine analogues: 3-Substituted 5-(2-phenoxybenzyl)-4H-1,2,4-triazoles and 2-amino-5-(phenoxybenzyl)-1,3,4-oxadiazoles.
Topics: Animals; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred Strains; Models, Molecular; Molecular Structure; Oxadiazoles; Pentylenetetrazole; Receptors, GABA-A; Seizures; Structure-Activity Relationship; Triazoles | 2014 |
Phloem mobility and translocation of fluorescent conjugate containing glucose and NBD in castor bean (Ricinus communis).
Topics: Chromatography, High Pressure Liquid; Cotyledon; Fluorescent Dyes; Glucose; Glucosides; Microscopy, Fluorescence; Oxadiazoles; Phloem; Ricinus; Tandem Mass Spectrometry; Time Factors; Triazoles | 2014 |
Antioxidant and antitumor activities of new synthesized aromatic C-nucleoside derivatives.
Topics: Antineoplastic Agents; Antioxidants; Biphenyl Compounds; Cell Line, Tumor; Cell Survival; Humans; Hydrazines; Molecular Structure; Nucleosides; Oxadiazoles; Picrates; Structure-Activity Relationship; Thiosemicarbazones; Triazoles | 2014 |
AZD9272 and AZD2066: selective and highly central nervous system penetrant mGluR5 antagonists characterized by their discriminative effects.
Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Isoxazoles; Male; Oxadiazoles; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Thiazoles; Triazoles | 2014 |
Preclinical antitumor efficacy of selective exportin 1 inhibitors in glioblastoma.
Topics: Acrylamides; Active Transport, Cell Nucleus; Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Cycle Checkpoints; Cell Differentiation; Cell Line, Tumor; Dose-Response Relationship, Drug; Exportin 1 Protein; Glioblastoma; Humans; Hydrazines; Karyopherins; Macaca fascicularis; Male; Mice; Oxadiazoles; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Thiazoles; Treatment Outcome; Triazoles; Xenograft Model Antitumor Assays | 2015 |
Synthesis of some novel heterocylic compounds derived from 2-[3-(4-chlorophenyl)-5-(4-methoxybenzyl)-4H-1,2,4-triazol-4-yl]acetohydrazide and investigation of their lipase and α-glucosidase inhibition.
Topics: alpha-Glucosidases; Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heterocyclic Compounds; Lipase; Molecular Structure; Oxadiazoles; Pancreas; Saccharomyces cerevisiae; Semicarbazides; Structure-Activity Relationship; Swine; Triazoles | 2015 |
Hydroxyl functionalized polytriazole-co-polyoxadiazole as substrates for forward osmosis membranes.
Topics: Membranes, Artificial; Osmosis; Oxadiazoles; Polymers; Porosity; Triazoles; Water Purification | 2015 |
Radical-based route to 2-(trifluoromethyl)-1,3,4-oxadiazoles and trifluoromethyl-substituted polycyclic 1,2,4-triazoles and dihydrofurans.
Topics: Alkenes; Cycloaddition Reaction; Furans; Molecular Structure; Oxadiazoles; Triazoles | 2015 |
Synthesis and evaluation of benzosuberone embedded with 1,3,4-oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole moieties as new potential anti proliferative agents.
Topics: Antineoplastic Agents; Azoles; Cell Line, Tumor; Cell Proliferation; Coumarins; Humans; Molecular Structure; Oxadiazoles; Thiadiazoles; Triazoles | 2015 |
Distinct pro-vigilant profile induced in rats by the mGluR5 potentiator LSN2814617.
Topics: Animals; Arousal; Benzhydryl Compounds; Biofeedback, Psychology; Caffeine; Central Nervous System Stimulants; Conditioning, Operant; Dextroamphetamine; Electroencephalography; Excitatory Amino Acid Agonists; Male; Modafinil; Oxadiazoles; Psychomotor Performance; Pyridines; Rats; Rats, Wistar; Reaction Time; Receptor, Metabotropic Glutamate 5; Sleep; Sleep Deprivation; Sleep, REM; Triazoles | 2015 |
Synthesis and anticancer evaluation of 1,3,4-oxadiazoles, 1,3,4-thiadiazoles, 1,2,4-triazoles and Mannich bases.
Topics: Antineoplastic Agents; Cell Line, Tumor; Humans; Mannich Bases; Molecular Structure; Oxadiazoles; Thiadiazoles; Triazoles | 2015 |
Anti-tumor activity of selective inhibitors of XPO1/CRM1-mediated nuclear export in diffuse malignant peritoneal mesothelioma: the role of survivin.
Topics: Acrylamides; Active Transport, Cell Nucleus; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Exportin 1 Protein; G1 Phase Cell Cycle Checkpoints; Humans; Hydrazines; Inhibitor of Apoptosis Proteins; Karyopherins; Lung Neoplasms; Mesothelioma; Mesothelioma, Malignant; Mice; Mice, SCID; Neoplasm Proteins; Oxadiazoles; Peritoneal Neoplasms; Real-Time Polymerase Chain Reaction; Receptors, Cytoplasmic and Nuclear; Survivin; Thiazoles; Triazoles; Tumor Suppressor Protein p53 | 2015 |
Synthesis of Novel 2,5-Disubstituted-1,3,4-thiadiazoles Clubbed 1,2,4-Triazole, 1,3,4-Thiadiazole, 1,3,4-Oxadiazole and/or Schiff Base as Potential Antimicrobial and Antiproliferative Agents.
Topics: Anti-Infective Agents; Antineoplastic Agents; Oxadiazoles; Proton Magnetic Resonance Spectroscopy; Schiff Bases; Thiadiazoles; Triazoles | 2015 |
KPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and survivin [corrected] in prostate cancer models.
Topics: Adult; Analgesics; Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin D1; Gene Expression Regulation, Neoplastic; Humans; Hydrazines; Inhibitor of Apoptosis Proteins; Male; Mice; Mice, Nude; Neoplasm Grading; Oxadiazoles; Prostatic Neoplasms; Survivin; Triazoles; Up-Regulation; Xenograft Model Antitumor Assays | 2015 |
Syntheses and biological evaluation of 1,2,3-triazole and 1,3,4-oxadiazole derivatives of imatinib.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Imatinib Mesylate; K562 Cells; Molecular Structure; Oxadiazoles; Structure-Activity Relationship; Triazoles | 2016 |
Determination of l-tryptophan and l-kynurenine derivatized with (R)-4-(3-isothiocyanatopyrrolidin-1-yl)-7-(N,N-dimethylaminosulfonyl)-2,1,3-benzoxadiazole by LC-MS/MS on a triazole-bonded column and their quantification in human serum.
Topics: Chromatography, High Pressure Liquid; Female; Humans; Isothiocyanates; Kynurenine; Limit of Detection; Male; Oxadiazoles; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry; Triazoles; Tryptophan | 2016 |
dl-3-n-butylphthalide suppresses PDGF-BB-stimulated vascular smooth muscle cells proliferation via induction of autophagy.
Topics: Animals; Autophagosomes; Autophagy; Becaplermin; Benzofurans; beta Catenin; Cell Cycle; Cell Proliferation; Cells, Cultured; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxadiazoles; Proto-Oncogene Proteins c-sis; Rats; Triazoles | 2016 |
Anti-tumor activity of selective inhibitor of nuclear export (SINE) compounds, is enhanced in non-Hodgkin lymphoma through combination with mTOR inhibitor and dexamethasone.
Topics: Acrylamides; Active Transport, Cell Nucleus; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Survival; Cyclophosphamide; Dexamethasone; Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Everolimus; Exportin 1 Protein; Humans; Hydrazines; Karyopherins; Lymphoma, Non-Hodgkin; Mice, Inbred ICR; Mice, SCID; Oxadiazoles; Prednisone; Protein Kinase Inhibitors; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Thiazoles; Time Factors; TOR Serine-Threonine Kinases; Transcription Factor RelA; Triazoles; Tumor Burden; Vincristine; Xenograft Model Antitumor Assays | 2016 |
Synthesis and biological evaluation of 1,2,4-triazole-3-thione and 1,3,4-oxadiazole-2-thione as antimycobacterial agents.
Topics: Antitubercular Agents; Cell Line, Tumor; Humans; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxadiazoles; Thiones; Triazoles; Tuberculosis | 2017 |
Synthesis and Biological Activities of Ethyl 2-(2-pyridylacetate) Derivatives Containing Thiourea, 1,2,4-triazole, Thiadiazole and Oxadiazole Moieties.
Topics: Anti-Infective Agents; Bacteria; Cell Line; Cells, Cultured; Crystallography, X-Ray; Fungi; HIV-1; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Oxadiazoles; Structure-Activity Relationship; Thiadiazoles; Thiourea; Triazoles | 2017 |
Synthesis and molecular docking study of some 5,6-dichloro-2-cyclopropyl-1H-benzimidazole derivatives bearing triazole, oxadiazole, and imine functionalities as potent inhibitors of urease.
Topics: Benzimidazoles; Canavalia; Dose-Response Relationship, Drug; Enzyme Inhibitors; Imines; Molecular Docking Simulation; Molecular Structure; Oxadiazoles; Structure-Activity Relationship; Triazoles; Urease | 2017 |
1,2,4-Triazole and 1,3,4-oxadiazole analogues: Synthesis, MO studies, in silico molecular docking studies, antimalarial as DHFR inhibitor and antimicrobial activities.
Topics: Anti-Infective Agents; Antimalarials; Folic Acid Antagonists; Molecular Docking Simulation; Oxadiazoles; Spectrum Analysis; Triazoles | 2017 |
The synthesis, antifungal and apoptotic effects of triazole-oxadiazoles against Candida species.
Topics: Antifungal Agents; Candida; Candidiasis; Humans; Microbial Sensitivity Tests; Oxadiazoles; Structure-Activity Relationship; Triazoles | 2018 |
Synthesis and antimicrobial activity of pyrimidinyl 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles.
Topics: Anti-Bacterial Agents; Antifungal Agents; Aspergillus niger; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Molecular Structure; Oxadiazoles; Pseudomonas aeruginosa; Pyrimidines; Structure-Activity Relationship; Thiadiazoles; Triazoles | 2018 |
Synthesis and Biological Evaluation of 1,2,4-Triazoles and 1,3,4-Oxadiazoles Derivatives Linked to 1,4-Dihydropyridines Scaffold.
Topics: Anti-Infective Agents; Dihydropyridines; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Oxadiazoles; Spectroscopy, Fourier Transform Infrared; Triazoles | 2017 |
Design and synthesis of novel dasatinib derivatives as inhibitors of leukemia stem cells.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Dasatinib; Drug Design; Drug Screening Assays, Antitumor; Humans; Leukemia; Mice; Neoplastic Stem Cells; Oxadiazoles; Triazoles | 2018 |
New Quinoline-Based Heterocycles as Anticancer Agents Targeting Bcl-2.
Topics: Apoptosis; Cell Line; Cell Line, Tumor; Enzyme-Linked Immunosorbent Assay; Heterocyclic Compounds; Humans; Hydrocarbons, Aromatic; Inhibitory Concentration 50; Leukemia, Lymphocytic, Chronic, B-Cell; Magnetic Resonance Spectroscopy; Oxadiazoles; Proto-Oncogene Proteins c-bcl-2; Quinolines; Triazoles | 2019 |
Oxadiazole Derivatives as Dual Orexin Receptor Antagonists: Synthesis, Structure-Activity Relationships, and Sleep-Promoting Properties in Rats.
Topics: Animals; Azepines; Cytochrome P-450 CYP3A; Dogs; Half-Life; Humans; Inhibitory Concentration 50; Orexin Receptor Antagonists; Orexin Receptors; Oxadiazoles; Rats; Sleep; Structure-Activity Relationship; Triazoles | 2019 |
Synthesis of cytotoxic urs-12-ene- and 28-norurs-12-ene- type conjugates with amino- and mercapto-1,3,4-oxadiazoles and mercapto-1,2,4-triazoles.
Topics: Antineoplastic Agents; Apoptosis; Cell Line; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Molecular Structure; Oxadiazoles; Stereoisomerism; Triazoles; Triterpenes | 2020 |
From Oxadiazole to Triazole Analogues: Optimization toward a Dual Orexin Receptor Antagonist with Improved in vivo Efficacy in Dogs.
Topics: Animals; Dogs; Male; Molecular Conformation; Orexin Receptor Antagonists; Orexin Receptors; Oxadiazoles; Rats; Rats, Wistar; Sleep; Stereoisomerism; Triazoles | 2020 |
Synthesis and cytotoxicity of hybrids of 1,3,4- or 1,2,5-oxadiazoles tethered from ursane and lupane core with 1,2,3-triazole.
Topics: Antineoplastic Agents; Chemistry Techniques, Synthetic; Hep G2 Cells; Humans; MCF-7 Cells; Molecular Docking Simulation; Oxadiazoles; Protein Conformation; Proto-Oncogene Proteins c-mdm2; Triazoles; Triterpenes | 2020 |
Synthesis of New Planar-Chiral Linked [2.2]Paracyclophanes-
Topics: Cyclization; Isothiocyanates; Molecular Structure; Oxadiazoles; Oxidation-Reduction; Solvents; Stereoisomerism; Thiones; Triazoles | 2020 |
Evaluation of Biological Activity of Derivatives of 1,3,4-Thiadiazole, 1,3,4-Oxadiazole and 1,2,4-Triazole.
Topics: Animals; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Edema; Erythrocyte Membrane; Female; Male; Oxadiazoles; Peptide Hydrolases; Protease Inhibitors; Rats; Thiadiazoles; Triazoles | 2021 |
Design, synthesis and biological evaluation of triazole-oxadiazole conjugates for the management of cognitive dysfunction.
Topics: Animals; Cognitive Dysfunction; Humans; Male; Molecular Docking Simulation; Oxadiazoles; Triazoles | 2020 |
Synthesis of [1,2,4]triazolo[4,3-a]quinoxaline-1,3,4-oxadiazole derivatives as potent antiproliferative agents via a hybrid pharmacophore approach.
Topics: Antineoplastic Agents; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Oxadiazoles; Quinoxalines; Structure-Activity Relationship; Triazoles; Tumor Cells, Cultured | 2020 |
Synthesis of Novel Triazolyl/Oxadiazolyl/Thiadiazolyl-Piperazine as Potential Anticonvulsant Agents.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Female; Humans; Male; Mice; Oxadiazoles; Piperazine; Rats; Seizures; Structure-Activity Relationship; Thiadiazoles; Toxicity Tests, Acute; Triazoles | 2021 |
Design, synthesis, and antibacterial evaluation of new quinoline-1,3,4-oxadiazole and quinoline-1,2,4-triazole hybrids as potential inhibitors of DNA gyrase and topoisomerase IV.
Topics: Anti-Bacterial Agents; DNA Gyrase; DNA Topoisomerase IV; Dose-Response Relationship, Drug; Drug Design; Escherichia coli; Microbial Sensitivity Tests; Molecular Structure; Oxadiazoles; Quinolines; Staphylococcus aureus; Structure-Activity Relationship; Topoisomerase II Inhibitors; Triazoles | 2021 |
Synthesis of alkynylated 1,2,4-oxadiazole/1,2,3-1H-triazole glycoconjugates: Discovering new compounds for use in chemotherapy against lung carcinoma and Mycobacterium tuberculosis.
Topics: Alkynes; Animals; Antineoplastic Agents; Antitubercular Agents; Carcinoma, Squamous Cell; Cell Line; Cell Proliferation; Cell Survival; Chlorocebus aethiops; Dose-Response Relationship, Drug; Drug Discovery; Glycoconjugates; Humans; Lung Neoplasms; Mice; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Oxadiazoles; Structure-Activity Relationship; Triazoles | 2021 |
Evaluation of Amide Bioisosteres Leading to 1,2,3-Triazole Containing Compounds as GPR88 Agonists: Design, Synthesis, and Structure-Activity Relationship Studies.
Topics: Animals; Benzeneacetamides; Blood-Brain Barrier; Corpus Striatum; Drug Design; Male; Mice, Inbred C57BL; Mice, Knockout; Molecular Structure; Oxadiazoles; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Triazoles | 2021 |
Exploring the Synergistic Anticancer Potential of Benzofuran-Oxadiazoles and Triazoles: Improved Ultrasound- and Microwave-Assisted Synthesis, Molecular Docking, Hemolytic, Thrombolytic and Anticancer Evaluation of Furan-Based Molecules.
Topics: A549 Cells; Antineoplastic Agents; Benzofurans; Cell Survival; Chemistry Techniques, Synthetic; Hemolysis; Humans; Microwaves; Molecular Docking Simulation; Neoplasms; Oxadiazoles; Triazoles | 2022 |
New 1,3,4-oxadiazoles linked with the 1,2,3-triazole moiety as antiproliferative agents targeting the EGFR tyrosine kinase.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Drug Screening Assays, Antitumor; ErbB Receptors; Erlotinib Hydrochloride; Humans; Molecular Structure; Oxadiazoles; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Structure-Activity Relationship; Triazoles | 2022 |
Design and Synthesis of Novel 1,3,4-Oxadiazole and 1,2,4-Triazole Derivatives as Cyclooxygenase-2 Inhibitors with Anti-inflammatory and Antioxidant activity in LPS-stimulated RAW264.7 Macrophages.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Design; Interleukin-6; Lipopolysaccharides; Macrophages; Molecular Docking Simulation; Nitric Oxide; Oxadiazoles; Reactive Oxygen Species; Structure-Activity Relationship; Triazoles | 2022 |
Synthesis of 4-Hydroxycoumarin-Based Triazoles/Oxadiazoles as Novel Anticancer Agents.
Topics: 4-Hydroxycoumarins; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Oxadiazoles; Structure-Activity Relationship; Triazoles | 2022 |