isoconazole

Description

Isoconazole is an antifungal medication that is used to treat a variety of fungal infections. It is a synthetic imidazole derivative and works by inhibiting the synthesis of ergosterol, a vital component of fungal cell membranes. This disruption leads to fungal cell death. Isoconazole is available in various formulations, including creams, lotions, and vaginal tablets. It is often prescribed for superficial fungal infections like athlete's foot, jock itch, and vaginal yeast infections. Isoconazole has demonstrated efficacy in treating fungal infections caused by a range of organisms, including Candida species, Malassezia globosa, and Trichophyton species. However, its use is generally restricted to topical applications due to limited systemic bioavailability. Research on isoconazole focuses on its antifungal activity, its mechanisms of action, its potential applications in treating resistant fungal infections, and its safety profile. It is also studied for its potential use in combination therapies with other antifungal agents. The compound's effectiveness, ease of application, and relatively good safety profile have made it a valuable treatment option for a variety of fungal infections.'

1-{2-[(2,6-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}imidazole : A member of the class of imidazoles that carries a 2-[(2,6-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl group at position 1. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

isoconazole : A racemate comprising equimolar amounts of (R)- and (S)-isoconazole. A broad-spectrum antibacterial drug used (as its nitrate salt) for treatment of dermatomycoses. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]