Immune Reconstitution Disease

Exuberant inflammatory response towards a previously acquired or undiagnosed opportunistic infection. It is frequently seen in AIDS patients following antiretroviral treatment.

Synonym
Immune Restoration Disease
Immune Reconstitution Inflammatory Syndrome
Immune Restoration Syndrome
Immune Reconstitution Syndrome
Immune Reconstitution Disease

Excerpt	Reference
"Immune reconstitution inflammatory syndrome is recognized as a paradoxical worsening of preexisting or smoldering opportunistic infections in patients with human immunodeficiency virus on highly active antiretroviral therapy because of the recuperating of immune system."	( Chen, WL; Lin, YF; Tsai, WC; Tsao, YT, 2009)
"Immune reconstitution inflammatory syndrome is an adverse consequence of the restoration of pathogen-specific immune responses during the early phase of antiretroviral therapy."	( Lin, YT; Tsao, YT; Wu, YC; Yang, CS, 2009)
"Immune reconstitution inflammatory syndrome is a clinical entity with a broad presentation, described in both HIV and non-HIV-infected patients."	( Babu, TM; Laguio, M; Larppanichpoonphol, P; Luque, AE, 2014)
"Immune reconstitution inflammatory syndrome is a rare complication of the treatment of Whipple's disease."	( D'Incan, M; Dubost, JJ; Soubrier, M; Tournadre, A; Vayssade, M, 2015)
"Immune reconstitution inflammatory syndrome is an inflammatory reaction in HIV-infected patients after initiation of antiretroviral therapy resulting from restored immunity to specific infectious or non-infectious antigens."	( Ali, NM; Kumar, P; Nayak, K, 2017)
"Paradoxical immune reconstitution inflammatory syndrome is a well-described entity even in immunocompetent children, principally in association with Mycobacterium tuberculosis infections."	( Boucher, FD; Drolet, JP; Thibeault, R; Viel-Thériault, I, 2016)
"KS associated with immune reconstitution inflammatory syndrome is rare, especially in children, but with the increased use of ART is becoming more prevalent."	( Amaro, C; Azurara, L; Miroux-Catarino, A; Monteiro, AF; Silva, L; Viana, I, 2020)

Excerpt	Reference
"Recently, immune reconstitution syndrome has also been described in transplant recipients, although information is scarce because of its low incidence."	( Cervera, C; Crespo, G; Marco, F; Michelena, J; Moreno, A; Navasa, M, 2008)
"Immune reconstitution inflammatory syndrome has been described in Kaposi sarcoma, but does not usually manifest as acute hepatitis."	( Kulasegaram, R; Lucas, S; Morris, S; Read, PJ, 2013)

Excerpt	Reference
"This entity was defined as immune reconstitution syndrome, and it is believed to result from an intense inflammatory reaction in patients with an appropriately treated infection who recover immunological status."	( Cervera, C; Crespo, G; Marco, F; Michelena, J; Moreno, A; Navasa, M, 2008)
"We hypothesize that CNS immune reconstitution inflammatory syndrome (IRIS) after highly active antiretroviral therapy (HAART) in HIV-1-positive patients may become manifest without any opportunistic infection as an aseptic leucoencephalopathy."	( Arendt, G; Dziewas, R; Hasselblatt, M; Husstedt, IW; Mathys, C; Niederstadt, T; Oelschlaeger, C; Reichelt, D; Ringelstein, A; Saleh, A, 2009)
"Paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is a frequent complication of antiretroviral therapy in resource-limited countries."	( Maartens, G; Meintjes, G; Morroni, C; Oni, T; Pepper, DJ; Rangaka, MX; Rebe, K; Wilkinson, RJ, 2010)
"Cryptococcal immune reconstitution inflammatory syndrome (IRIS) may present as a clinical worsening or new presentation of cryptococcal disease after initiation of antiretroviral therapy (ART), and is thought to be caused by recovery of cryptococcus-specific immune responses."	( Bohjanen, PR; Boulware, DR; Colebunders, R; Easterbrook, PJ; Elliott, JH; French, MA; Haddow, LJ; Lawn, SD; Manabe, YC; Meintjes, G; Sungkanuparph, S, 2010)
"To demonstrate that the immune reconstitution inflammatory syndrome (IRIS) occurs in patients treated for Whipple disease."	( Allers, K; Biagi, F; Bläker, H; Feurle, GE; Geelhaar, A; Jansen, A; Loddenkemper, C; Moos, V; Moter, A; Schinnerling, K; Schneider, T, 2010)
"To estimate the impact of immune reconstitution inflammatory syndrome (IRIS) on morbidity and mortality in patients starting highly-active antiretroviral therapy (HAART)."	( Belaunzarán-Zamudio, PF; Crabtree-Ramirez, B; Galindo-Fraga, A; Hoyo-Ulloa, I; Pérez-Aguinaga, ME; Sierra-Madero, JG, 2011)
"Given the well documented occurrence of immune reconstitution inflammatory syndrome (IRIS) in HIV-infected patients who recently started combination antiretroviral therapy (cART), we examined whether cART initiation increased the risk of Kaposi sarcoma and non-Hodgkin lymphoma (NHL) using data from the Concerted Action on SeroConversion to AIDS and Death in Europe (CASCADE) collaboration."	( Carpenter, LM; Cox, DR; De Stavola, BL; Jaffe, HW; Porter, K, 2011)
"In the case of Immune reconstitution inflammatory syndrome (IRIS) or inflammatory lesions of the CNS in the setting of Whipple's disease, additional treatment with corticosteroids should be considered to avoid severe tissue damage."	( Loddenkemper, C; Moos, V; Schneider, T, 2011)
"Tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is an early complication of combination antiretroviral therapy (cART)."	( Goliath, R; Meintjes, G; Seldon, R; Wilkinson, KA; Wilkinson, RJ, 2012)
"HIV-tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is an immunopathological reaction to mycobacterial antigens induced by antiretroviral therapy."	( Colebunders, R; Conesa-Botella, A; Maartens, G; Matthews, K; Meintjes, G; Morroni, C; Pepper, DJ; Rangaka, MX; Rebe, K; Seldon, R; Skolimowska, KH; Tadokera, R; Wilkinson, KA; Wilkinson, RJ, 2012)
"Management of relapsing or refractory immune reconstitution inflammatory syndromes (IRISs) despite corticosteroid therapy is yet to be defined."	( Brunel, AS; Le Moing, V; Lortholary, O; Makinson, A; Montes, B; Reynes, J; Rubbo, PA; Tuaillon, E, 2012)
"Concerns about the immune reconstitution inflammatory syndrome (IRIS) remain a barrier to antiretroviral therapy (ART) initiation during antituberculosis treatment in co-infected patients."	( Abdool Karim, S; Bamber, S; El-Sadr, WM; Friedland, G; Gengiah, S; Jithoo, N; Naidoo, K; Nair, G; Padayatchi, N; Yende-Zuma, N, 2012)
"The HIV-TB-associated immune reconstitution inflammatory syndrome (TB-IRIS) can complicate combined treatments for HIV-1 and TB."	( Elkington, PT; Friedland, JS; Maartens, G; Meintjes, GA; Skolimowska, KH; Tadokera, R; Walker, N; Wilkinson, KA; Wilkinson, RJ, 2014)
"This immune reconstitution inflammatory syndrome (TB-IRIS) can lead to significant morbidity and needs to be distinguished from TB recurrence due to ineffective treatment."	( Boucherie, C; Breton, G; Bugault, F; Chakrabarti, LA; Chêne, G; Cumont, MC; Lortholary, O; Patey, O; Richert, L; Roussillon, C, 2014)
"This clinical condition, known as immune reconstitution inflammatory syndrome, may cause significant morbidity and even mortality if it is not promptly recognized and treated."	( Gatell, JM; Guardo, AC; Letang, E; Manzardo, C; Miro, JM; Plana, M, 2015)
"We have also analysed two PML/IRIS (immune reconstitution inflammatory syndrome) patients and four longitudinal samples of a NTZ-treated patients before and during the development of a clinical asymptomatic magnetic resonance imaging (MRI) lesion confirmed as PML by cerebrospinal fluid (CSF) examination."	( Bertolotto, A; Caldano, M; Lugaresi, A; Marnetto, F; Spadaro, M, 2015)
"Paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) occurs in 8-54% of South African patients undergoing treatment for tuberculosis/human immunodeficiency virus co-infection."	( Bell, L; Blackburn, JM; Garnett, S; Meintjes, G; Peyper, JM; Tadokera, R; Wilkinson, R, 2017)
"Tuberculosis associated Immune reconstitution inflammatory syndrome (IRIS) in a HIV negative patient can present with a multitude of clinic-radiological presentations that are often confused with drug resistance/treatment failure."	( Aggarwal, D; Bhardwaj, M; Kumar, A; Saini, V; Sawal, N, 2020)
"BACKGROUND Immune reconstitution inflammatory syndrome (IRIS) is a well-recognized complication after antiretroviral therapy (ART) initiation among patients with HIV."	( Arshad, I; Feinstein, A; Gandhi, M; Gossai, M, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	65 (19.52)	18.1394
2010's	228 (68.47)	28.8240
2020's	40 (12.01)	9.53

Drug	Relationship Strength	Studies	Trials
adenine	medium	8	1
cytosine	low	2	0
kynurenine	low	2	0
porphobilinogen	low	1	0
pyrazinamide	low	1	0
phenytoin	low	1	0
clofazimine	low	1	0
dapsone	low	4	0
diclofenac	low	1	0
fluconazole	low	17	0
flucytosine	low	4	0
hydroxychloroquine	low	4	0
ibuprofen	low	1	0
isoniazid	medium	7	1
mesalamine	low	1	0
mianserin	low	2	0
mirtazapine	low	2	0
nevirapine	medium	3	1
praziquantel	low	1	0
pyrimethamine	low	1	0
ritanserin	low	1	0
sulfasalazine	low	1	0
thalidomide	low	10	0
prednisolone	low	12	0
thyroxine	low	2	0
prednisone	medium	24	4
dehydroepiandrosterone	low	1	0
galactose	low	1	0
fluocinolone acetonide	low	1	0
cytarabine	low	1	0
valine	medium	2	1
tryptophan	low	2	0
methylprednisolone	low	14	0
pyridostigmine bromide	low	1	0
meglumine	low	1	0
hydrazine	low	1	0
lucanthone hydrochloride	low	1	0
dehydroepiandrosterone sulfate	low	1	0
deoxycytidine	medium	7	1
ethambutol	medium	4	1
stavudine	low	5	0
streptomycin	medium	4	1
gadolinium	low	3	0
trolamine salicylate	medium	4	1
phenyl acetate	low	1	0
glutamic acid	low	1	0
zidovudine	medium	5	1
paclitaxel	low	2	0
etoposide	medium	2	2
itraconazole	low	1	0
cidofovir anhydrous	low	2	0
lamivudine	medium	12	1
emtricitabine	medium	6	1
efavirenz	medium	15	2
glucose, (beta-d)-isomer	low	1	0
meglumine antimoniate	low	1	0
triazoles	low	9	0
fluorodeoxyglucose f18	low	5	0
voriconazole	low	4	0
clarithromycin	low	4	0
fibrinogen	low	1	0
lopinavir	low	5	0
fingolimod hydrochloride	low	8	0
clofarabine	low	1	0
methotrexate	low	2	0
combivir	low	1	0
organophosphonates	medium	9	1
etravirine	medium	1	1
darunavir	low	1	0
deoxycholic acid	low	1	0
trimethoprim, sulfamethoxazole drug combination	low	7	0
ritonavir	low	6	0
epiglucan	low	2	0
pentostatin	low	1	0
meropenem	low	1	0
abacavir	medium	4	1
fumaric acid	low	1	0
tacrolimus	low	2	0
mycophenolic acid	low	1	0
clindamycin	low	1	0
tenofovir	medium	6	1
posaconazole	low	1	0
methimazole	low	2	0
terbinafine	low	1	0
maraviroc	low	7	0
galactomannan	low	1	0
abacavir, lamivudine drug combination	low	2	0
sphingosine	low	1	0
cholecalciferol	low	1	0
amphotericin b	medium	18	1
montelukast	low	1	0
phenylephrine hydrochloride	low	2	0
fumarates	low	1	0
rilpivirine	low	1	0
gs-7340	low	1	0
efavirenz, emtricitabine, tenofovir disoproxil fumarate drug combination	low	1	0
tofacitinib	low	2	0
idelalisib	low	1	0
dextrothyroxine	low	1	0
mefloquine	low	3	0
enfuvirtide	low	1	0
raltegravir potassium	medium	1	1
amphotericin b, deoxycholate drug combination	low	1	0
ro13-9904	low	2	0
pci 32765	low	1	0
mannans	low	1	0
glycolipids	low	1	0
piperidines	low	3	0
interleukin-8	low	2	0
teriflunomide	low	1	0
dolutegravir	low	4	0
thymic factor, circulating	low	1	0
rome	low	1	0
cyclosporine	low	1	0
apyrase	low	1	0
exudates	low	2	0
acyclovir	medium	4	2
levoleucovorin	low	1	0
rifampin	medium	8	2
ganciclovir	low	4	0
valacyclovir	medium	3	1
valganciclovir	low	2	0
amg531	low	1	0
eye	low	1	0
antimony sodium gluconate	low	1	0

Protein Targets (1,696)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Luciferase	11	0	0	11
cytochrome P450 family 3 subfamily A polypeptide 4	33	0	0	33
cytochrome P450 2D6	16	0	0	16
euchromatic histone-lysine N-methyltransferase 2	27	0	0	27
peripheral myelin protein 22	15	0	0	15
Albumin	0	2	8	14
ATP-dependent translocase ABCB1	0	12	1	16
Replicase polyprotein 1ab	0	6	2	8
Replicase polyprotein 1ab	0	8	3	11
Reverse transcriptase/RNaseH	0	11	11	38
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	15	0	16
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	6	0	0	6
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	6	0	0	6
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
thioredoxin reductase	14	0	0	14
GALC protein	5	0	0	5
GLI family zinc finger 3	27	0	0	27
nuclear receptor subfamily 1, group I, member 3	23	0	0	23
glucocorticoid receptor [Homo sapiens]	34	0	0	34
retinoic acid nuclear receptor alpha variant 1	25	0	0	25
retinoid X nuclear receptor alpha	27	0	0	27
estrogen-related nuclear receptor alpha	34	0	0	34
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
arylsulfatase A	11	0	0	11
Carbonic anhydrase	0	1	0	1
Bloom syndrome protein isoform 1	13	0	0	13
thyroid hormone receptor beta isoform a	10	0	0	10
nuclear factor erythroid 2-related factor 2 isoform 1	31	0	0	31
geminin	35	0	0	35
survival motor neuron protein isoform d	9	0	0	9
muscleblind-like protein 1 isoform 1	6	0	0	6
Gamma-aminobutyric acid receptor subunit pi	10	3	0	13
ATP-binding cassette sub-family C member 3	0	38	0	38
Multidrug resistance-associated protein 4	0	38	0	40
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	2	0	5
Carbonic anhydrase 12	0	2	1	6
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	48	0	48
Glycogen phosphorylase, muscle form	0	2	0	2
Renin	0	3	0	3
Carbonic anhydrase 1	0	5	1	13
Carbonic anhydrase 2	0	5	2	13
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	10	0	10
Carbonic anhydrase 3	0	2	1	6
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	23	0	25
Steryl-sulfatase	0	1	0	2
5-hydroxytryptamine receptor 2C	0	7	1	9
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cytochrome P450 2C8	0	6	0	7
Cytochrome P450 2D6	0	12	0	12
Cytochrome P450 2A6	0	4	0	4
Cytochrome P450 2C9	0	21	0	23
5-hydroxytryptamine receptor 2A	0	7	1	8
Androgen receptor	0	6	0	6
Gamma-aminobutyric acid receptor subunit beta-1	10	3	0	13
Translocator protein	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	10	3	0	13
Gamma-aminobutyric acid receptor subunit gamma-2	10	3	0	13
Gamma-aminobutyric acid receptor subunit alpha-5	10	3	0	13
Gamma-aminobutyric acid receptor subunit alpha-3	10	3	0	13
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	3	1	6
Carbonic anhydrase 4	0	2	1	5
Carbonic anhydrase 6	0	2	1	5
Gamma-aminobutyric acid receptor subunit gamma-1	10	3	0	13
Gamma-aminobutyric acid receptor subunit alpha-2	10	3	0	13
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	2	0	2
Serum paraoxonase/arylesterase 1	0	3	0	3
Dipeptidyl peptidase 4	0	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	10	3	0	13
Gamma-aminobutyric acid receptor subunit gamma-3	10	3	0	13
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	10	3	0	13
Adenosine receptor A2a	0	2	0	2
5-hydroxytryptamine receptor 2B	0	5	1	6
Sodium-dependent serotonin transporter	0	4	0	4
Delta-type opioid receptor	0	1	0	1
Cytochrome P450 2C19	0	11	0	12
Delta-type opioid receptor	0	3	0	3
Mu-type opioid receptor	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	2	1	7
Carbonic anhydrase	0	1	0	2
Kappa-type opioid receptor	0	4	0	4
Carbonic anhydrase 7	0	2	1	5
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	2	1	0	3
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	1	0	2
D(2) dopamine receptor	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-1	10	3	0	13
Gamma-aminobutyric acid receptor subunit beta-3	10	3	0	13
Gamma-aminobutyric acid receptor subunit beta-2	10	3	0	13
Cholinesterase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Fatty-acid amide hydrolase 1	0	3	0	3
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	5	1	8
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Carbonic anhydrase 9	0	3	1	7
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	4	0	4
Delta carbonic anhydrase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Renin	0	1	0	1
Carbonic anhydrase	0	1	0	2
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	2	1	4
GABA theta subunit	10	3	0	13
Canalicular multispecific organic anion transporter 1	0	39	0	40
Carbonic anhydrase 4	0	3	0	3
Carbonic anhydrase 15	0	1	0	3
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	2	0	4
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	10	3	0	13
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	2	1	6
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	2	1	7
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	8	0	0	8
Chain B, HADH2 protein	8	0	0	8
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Chain A, Ferritin light chain	9	0	0	9
Thymidine kinase	0	3	0	3
phosphopantetheinyl transferase	17	0	0	17
GLS protein	13	0	0	13
TDP1 protein	38	0	0	38
Smad3	8	0	0	8
thyroid stimulating hormone receptor	9	0	0	9
EWS/FLI fusion protein	26	0	0	26
activating transcription factor 6	7	0	0	7
Histone H2A.x	13	0	0	13
hemoglobin subunit beta	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
lamin isoform A-delta10	32	0	0	32
Solute carrier family 22 member 1	0	3	0	5
Bile salt export pump	0	11	0	11
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	4	0	7
POU domain, class 2, transcription factor 2	0	0	0	2
Cytochrome P450 2J2	0	5	0	5
Disintegrin and metalloproteinase domain-containing protein 17	2	2	0	4
Purine nucleoside phosphorylase	0	0	2	2
Solute carrier family 22 member 6	0	3	0	9
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	6
Thymidine kinase	0	2	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	17	0	0	17
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
RAR-related orphan receptor gamma	25	0	0	25
AR protein	36	0	0	36
pregnane X nuclear receptor	29	0	0	29
estrogen nuclear receptor alpha	50	0	0	50
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	15	0	0	15
nuclear factor erythroid 2-related factor 2 isoform 2	11	0	0	11
heat shock protein beta-1	7	0	0	7
importin subunit beta-1 isoform 1	7	0	0	7
snurportin-1	7	0	0	7
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	3	0	0	3
Voltage-dependent calcium channel gamma-2 subunit	13	0	0	13
Cyclin-dependent kinase 1	0	1	3	4
Heat shock protein HSP 90-beta	0	1	0	1
Glutamate receptor 2	13	3	1	17
Xanthine dehydrogenase/oxidase	0	1	0	1
TAR DNA-binding protein 43	8	0	0	8
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	1	3
ATPase family AAA domain-containing protein 5	14	0	0	14
Ataxin-2	17	0	0	17
acetylcholinesterase	8	0	0	8
hypoxia-inducible factor 1 alpha subunit	8	0	0	8
estrogen receptor 2 (ER beta)	17	0	0	17
progesterone receptor	18	0	0	18
farnesoid X nuclear receptor	19	0	0	19
G	20	0	0	20
peroxisome proliferator-activated receptor delta	19	0	0	19
peroxisome proliferator activated receptor gamma	25	0	0	25
vitamin D (1,25- dihydroxyvitamin D3) receptor	21	0	0	21
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	7	0	0	7
v-jun sarcoma virus 17 oncogene homolog (avian)	12	0	0	12
Solute carrier organic anion transporter family member 2B1	0	7	0	8
Interferon beta	26	0	0	26
HLA class I histocompatibility antigen, B alpha chain	20	0	0	20
Thrombopoietin receptor	0	0	1	1
Potassium voltage-gated channel subfamily H member 2	0	13	0	13
Sodium channel protein type 5 subunit alpha	0	5	0	5
Inositol hexakisphosphate kinase 1	20	0	0	20
Solute carrier organic anion transporter family member 1B3	0	13	0	17
Potassium voltage-gated channel subfamily D member 3	0	3	0	3
Solute carrier organic anion transporter family member 1B1	0	12	0	16
cytochrome P450 2C9, partial	20	0	0	20
Chain A, Cruzipain	6	0	0	6
interleukin 8	5	0	0	5
tumor necrosis factor	1	0	0	1
vitamin D3 receptor isoform VDRA	11	0	0	11
Nuclear receptor ROR-gamma	6	0	0	6
Aurora kinase B	0	1	3	4
15-lipoxygenase, partial	5	0	0	5
USP1 protein, partial	16	0	0	16
Microtubule-associated protein tau	12	0	0	12
aldehyde dehydrogenase 1 family, member A1	19	0	0	19
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
nuclear receptor ROR-gamma isoform 1	13	0	0	13
DNA polymerase kappa isoform 1	8	0	0	8
cytochrome P450 3A4 isoform 1	10	0	0	10
Cellular tumor antigen p53	25	0	0	25
60 kDa chaperonin	0	3	0	3
60 kDa heat shock protein, mitochondrial	0	4	0	4
Vitamin D3 receptor	0	2	2	6
Glycine receptor subunit alpha-1	0	0	1	1
Vitamin D3 receptor	0	0	1	1
10 kDa heat shock protein, mitochondrial	0	4	0	4
Thiosulfate sulfurtransferase	0	4	0	4
60 kDa chaperonin	0	4	0	4
10 kDa chaperonin	0	4	0	4
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Thymidine kinase	0	0	0	1
thyroid hormone receptor beta isoform 2	27	0	0	27
mitogen-activated protein kinase 1	10	0	0	10
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
streptokinase A precursor	0	0	5	5
Protein-arginine deiminase type-4	0	5	0	5
Fumarate hydratase	11	0	0	11
polyprotein	11	0	0	11
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	2	0	2
Spike glycoprotein	25	0	2	27
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	10	0	0	10
67.9K protein	12	0	0	12
cytochrome P450 2D6 isoform 1	5	0	0	5
chromobox protein homolog 1	15	0	0	15
potassium voltage-gated channel subfamily H member 2 isoform d	10	0	0	10
transcriptional regulator ERG isoform 3	5	0	0	5
mitogen-activated protein kinase kinase kinase kinase 2 isoform 1	0	0	1	1
eyes absent homolog 2 isoform a	1	0	0	1
mitogen-activated protein kinase kinase kinase 3 isoform 1	0	0	1	1
Estrogen receptor	0	0	3	3
Spike glycoprotein	0	0	1	1
5-hydroxytryptamine receptor 1A	0	5	1	8
Cruzipain	0	2	0	2
C-terminal-binding protein 1	1	0	0	1
Estrogen receptor beta	0	0	3	3
Beta-lactamase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Beta-lactamase OXA-7	0	0	0	1
Solute carrier family 15 member 1	0	3	0	4
Beta-lactamase TEM	0	1	0	2
Solute carrier family 15 member 2	0	1	0	1
Efflux transporter	0	1	0	1
Beta-lactamase	0	1	0	1
Solute carrier family 15 member 2	0	2	0	2
Metallo-b-lactamase	0	0	0	2
Beta-lactamase class B VIM-2	0	0	1	3
endonuclease IV	7	0	0	7
glp-1 receptor, partial	8	0	0	8
LMP1 [Human herpesvirus 4]	0	0	0	3
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	3	0	3
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	6	0	0	6
DNA polymerase iota isoform a (long)	12	0	0	12
transactivating tegument protein VP16 [Human herpesvirus 1]	0	3	0	3
nuclear receptor coactivator 3 isoform a	0	3	0	3
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase	0	1	0	1
Thymidylate synthase	0	2	0	3
Thymidine kinase	0	1	0	1
Deoxycytidine kinase	0	0	3	5
Probable deoxycytidylate deaminase	0	0	0	2
Cytidine deaminase	0	1	0	3
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Deoxynucleoside kinase	0	1	0	1
ATP-dependent phosphofructokinase	9	0	0	9
IDH1	10	0	0	10
Deoxycytidine kinase	0	0	0	1
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase	0	1	0	1
bromodomain adjacent to zinc finger domain 2B	5	0	0	5
cytochrome P450 2C9 precursor	6	0	0	6
Myeloperoxidase	0	3	0	3
Dihydrofolate reductase	0	5	0	5
Histamine H2 receptor	8	1	0	10
5-hydroxytryptamine receptor 6	0	3	0	4
Chain A, Pol Polyprotein	0	1	0	1
Chain A, Pol Polyprotein	0	1	0	1
Chain B, Pol Polyprotein	0	1	0	1
Chain A, Pol Polyprotein	0	1	0	1
Chain B, Pol Polyprotein	0	1	0	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, protease	0	1	0	1
Chain B, protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease (Retropepsin)	0	0	1	1
Chain B, Protease (Retropepsin)	0	0	1	1
Chain A, Protease (Retropepsin)	0	0	1	1
Chain B, Protease (Retropepsin)	0	0	1	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, HIV-1 protease	0	0	1	1
Chain B, HIV-1 protease	0	0	1	1
Chain A, HIV-1 protease	0	0	1	1
Chain B, HIV-1 protease	0	0	1	1
Chain A, HIV-1 Protease	0	0	1	1
Chain B, HIV-1 Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, HIV-1 protease	0	1	0	1
Chain B, HIV-1 protease	0	1	0	1
Chain A, HIV-1 protease	0	1	0	1
Chain B, HIV-1 protease	0	1	0	1
Chain A, HIV-1 protease	0	1	0	1
Chain B, HIV-1 protease	0	1	0	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	9	0	0	9
Gag-Pol polyprotein	0	3	0	3
Gag-Pol polyprotein	0	5	1	6
Potassium voltage-gated channel subfamily E member 1	0	3	0	3
Alpha-1B adrenergic receptor	0	11	2	13
Alpha-1D adrenergic receptor	0	9	2	11
Alpha-1A adrenergic receptor	0	11	2	13
Potassium voltage-gated channel subfamily KQT member 1	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
Protease	0	7	3	15
Gag-Pol polyprotein	0	1	0	1
Protease	0	6	5	12
SMAD family member 2	12	0	0	12
SMAD family member 3	12	0	0	12
aryl hydrocarbon receptor	12	0	0	12
thyroid stimulating hormone receptor	11	0	0	11
Sex hormone-binding globulin	0	0	1	1
Beta-glucuronidase	0	1	0	1
Corticosteroid-binding globulin	0	2	0	2
Beta-glucuronidase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	3	0	3
Alpha-synuclein	2	1	0	3
G-protein coupled bile acid receptor 1	0	0	3	3
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
Solute carrier organic anion transporter family member 1A4	0	2	0	4
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Multidrug resistance-associated protein 1	0	1	0	3
Solute carrier organic anion transporter family member 1A1	0	2	0	3
Solute carrier organic anion transporter family member 1A2	0	1	0	3
Solute carrier organic anion transporter family member 1A3	0	0	0	4
ATP-binding cassette sub-family C member 11	0	0	0	2
Solute carrier family 22 member 11	0	0	0	3
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Chain A, STEROID DELTA-ISOMERASE	0	0	1	1
Steroid Delta-isomerase	0	0	1	1
Ileal sodium/bile acid cotransporter	0	1	0	1
Bile acid receptor	0	1	1	2
Thymidine kinase 2	0	2	0	2
AAA family ATPase	0	0	0	1
nonstructural protein 1	5	0	0	5
glucocerebrosidase	2	0	0	2
peripheral myelin protein 22 isoform 1	4	0	0	4
DNA polymerase beta	5	0	0	5
M-phase phosphoprotein 8	6	0	0	6
neuropeptide S receptor isoform A	5	0	0	5
Aldo-keto reductase family 1 member B10	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	1	0	3
Prostaglandin G/H synthase 1	0	2	0	2
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Dihydrofolate reductase	0	9	0	10
Cytochrome c oxidase subunit 2	0	1	0	1
Fatty acid-binding protein, liver	0	3	0	3
Transthyretin	0	1	1	5
Prostaglandin G/H synthase 1	0	5	0	5
Interleukin-8	0	1	0	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Fatty acid-binding protein, intestinal	0	2	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	2	0	6
UDP-glucuronosyltransferase 1-6	0	3	0	3
UDP-glucuronosyltransferase 1A1	0	6	0	9
UDP-glucuronosyltransferase 1A4	0	2	0	3
Prostaglandin G/H synthase 1	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
C-X-C chemokine receptor type 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Prostaglandin G/H synthase 2	0	4	1	5
Prostaglandin G/H synthase 2	0	2	0	3
UDP-glucuronosyltransferase 1A3	0	0	0	2
UDP-glucuronosyltransferase 2B10	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Prostaglandin G/H synthase 2	0	4	0	4
Prostaglandin G/H synthase 2	0	2	0	2
Prostaglandin G/H synthase 1	0	2	0	3
Multidrug and toxin extrusion protein 1	0	3	0	3
P2Y purinoceptor 12	0	1	0	1
UDP-glucuronosyltransferase 1A7	0	1	0	2
UDP-glucuronosyltransferase 1A10	0	1	0	2
Chain A, PFV integrase	0	1	0	1
Chain A, PFV integrase	0	1	0	1
Chain A, PFV integrase	0	1	0	1
Solute carrier family 22 member 2	0	3	0	3
Integrase	0	0	1	1
Sigma intracellular receptor 2	0	2	0	2
Vesicular acetylcholine transporter	0	1	0	1
Integrase	0	3	1	4
Chain A, POL POLYPROTEIN	0	1	0	1
Chain A, POL POLYPROTEIN	0	1	0	1
Chain B, POL POLYPROTEIN	0	1	0	1
Chain A, POL POLYPROTEIN	0	1	0	1
Chain B, POL POLYPROTEIN	0	1	0	1
Chain A, Pol Polyprotein	0	1	0	1
Chain B, Pol Polyprotein	0	1	0	1
PPM1D protein	6	0	0	6
caspase 7, apoptosis-related cysteine protease	4	0	0	4
caspase-3	4	0	0	4
Prothrombin	0	2	0	2
Gag-Pol polyprotein	0	6	0	6
Acetylcholinesterase	0	0	0	2
Cannabinoid receptor 1	0	2	0	2
Microsomal triglyceride transfer protein large subunit	0	2	0	2
Envelope glycoprotein gp160 [Cleaved into: Surface protein gp120	0	1	0	1
Fructose-1,6-bisphosphatase 1	0	0	0	2
Reverse transcriptase	0	3	4	7
Cholesterol 24-hydroxylase	0	2	2	4
Env polyprotein	0	0	2	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	6
Pantothenate synthetase	0	2	0	2
Prothrombin	0	0	1	2
Regulatory protein E2	0	0	1	1
ATP-dependent translocase ABCB1	0	3	0	3
DNA topoisomerase 1	0	1	0	2
DNA topoisomerase 2-alpha	0	1	4	10
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
DNA topoisomerase 2	0	0	0	1
ATP-dependent translocase ABCB1	0	4	0	4
Glutamate receptor ionotropic, NMDA 1	0	3	1	6
Caspase-3	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	3	1	6
Glutamate receptor ionotropic, NMDA 2C	0	3	1	6
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	4	11
Glutamate receptor ionotropic, NMDA 2D	0	3	1	6
Tubulin beta-2B chain	0	1	1	4
Similar to alpha-tubulin isoform 1	0	1	1	4
Similar to alpha-tubulin isoform 1	0	1	0	3
Glutamate receptor ionotropic, NMDA 3B	0	3	1	6
Glutamate receptor ionotropic, NMDA 3A	0	3	1	6
Chain A, Reverse transcriptase/ribonuclease H	0	1	0	1
Chain B, p51 RT	0	1	0	1
Chain A, Reverse transcriptase/ribonuclease H	0	1	0	1
Chain B, p51 RT	0	1	0	1
Sphingosine 1-phosphate receptor 1	0	0	1	1
RCG53912, isoform CRA_a	0	0	0	1
Sphingosine kinase 1	0	0	0	1
Sphingosine kinase 2	0	3	0	4
Sphingosine kinase 1	0	2	0	3
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
apical membrane antigen 1, AMA1	3	0	0	3
unnamed protein product	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
bcl-2-like protein 11 isoform 1	0	0	1	1
Histone deacetylase 3	0	1	0	1
Rap guanine nucleotide exchange factor 3	3	0	0	3
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	2	0	2
Heme oxygenase 1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	3	4
Aromatase	0	2	0	2
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Cytochrome P450 11B2, mitochondrial	0	2	0	2
Heme oxygenase 2	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Histone deacetylase 4	0	1	0	1
Cytochrome P450 144	0	0	3	3
Steroid C26-monooxygenase	0	0	3	3
Steroid C26-monooxygenase	0	0	3	3
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Histone deacetylase 1	0	1	0	1
Lanosterol 14-alpha demethylase	0	3	1	4
Sterol 14-alpha demethylase	0	0	3	3
Sterol 14-alpha demethylase	0	2	2	4
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
14-alpha sterol demethylase	0	0	3	3
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
heat shock protein 90, putative	0	0	0	1
likely tRNA 2'-phosphotransferase	0	1	0	1
Skn7p	0	0	0	1
heat shock protein 90	0	0	1	1
calcineurin A1, putative	0	0	1	1
serine/threonine-protein kinase PLK1	3	0	0	3
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Chain A, 2-oxoglutarate Oxygenase	8	0	0	8
Glucocorticoid receptor	0	8	2	15
Glycine receptor subunit alpha-1	0	8	0	8
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
ATAD5 protein, partial	8	0	0	8
Lysine-specific demethylase 4E	0	1	0	1
NADP-dependent malic enzyme, mitochondrial	0	0	0	1
Solute carrier family 22 member 20	0	3	0	3
Prolyl 4-hydroxylase	0	2	0	2
Solute carrier family 22 member 6	0	3	0	3
Alpha-ketoglutarate-dependent dioxygenase FTO	0	2	0	2
Egl nine homolog 1	0	1	1	2
Methyl-accepting chemotaxis protein NahY	0	0	1	1
histone acetyltransferase KAT2A isoform 1	7	0	0	7
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
ClpP	2	0	0	2
NFKB1 protein, partial	3	0	0	3
Transitional endoplasmic reticulum ATPase	0	1	0	1
Asialoglycoprotein receptor 1	0	1	1	2
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
regulator of G-protein signaling 4	5	0	0	5
beta-2 adrenergic receptor	2	0	0	2
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Integrin beta-3	3	1	1	5
Integrin alpha-IIb	3	0	1	4
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	3	1	4
Glutamate receptor 3	0	3	1	4
Glutamate receptor 4	0	3	1	4
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	2
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Lysosomal protective protein	0	0	0	1
Genome polyprotein	0	1	0	1
Spike glycoprotein	0	0	2	2
Replicase polyprotein 1ab	0	0	3	3
Transmembrane protease serine 2	0	0	2	2
Procathepsin L	0	0	2	2
Muscarinic acetylcholine receptor M2	0	4	0	4
Muscarinic acetylcholine receptor M4	0	3	0	3
Muscarinic acetylcholine receptor M5	0	3	0	3
Alpha-2A adrenergic receptor	0	9	0	9
Replicase polyprotein 1a	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Muscarinic acetylcholine receptor M1	0	5	0	5
Alpha-2B adrenergic receptor	0	4	0	4
Alpha-2C adrenergic receptor	0	7	0	7
Muscarinic acetylcholine receptor M3	0	5	0	5
Alpha-1D adrenergic receptor	0	4	0	4
Cyclic GMP-AMP synthase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	3	0	3
Angiotensin-converting enzyme 2	0	0	2	2
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
Acid-sensing ion channel 3	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Epidermal growth factor receptor	0	6	4	10
Albumin	0	1	0	1
Albumin	0	0	1	1
Cholinesterase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
Acetylcholinesterase	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Caspase-1	0	3	0	3
Substance-P receptor	0	2	0	2
Aldo-keto reductase family 1 member C3	0	1	0	1
Caspase-4	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Bone morphogenetic protein receptor type-1B	0	0	3	3
Membrane-associated progesterone receptor component 1	0	0	2	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	1	2	3
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	0	1	0	1
Serine/threonine-protein kinase PLK4	0	0	3	3
ATP-dependent RNA helicase DDX3X	0	0	3	3
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	1	1	2
Pyridoxal kinase	0	0	3	3
Citron Rho-interacting kinase	0	0	3	3
Serine/threonine-protein kinase Chk1	0	1	3	4
Aurora kinase A	0	0	3	3
Cyclin-G-associated kinase	0	0	3	3
Ephrin type-B receptor 6	0	0	3	3
Peroxisomal acyl-coenzyme A oxidase 3	0	0	3	3
Receptor-interacting serine/threonine-protein kinase 2	0	0	3	3
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	3	3
Dynamin-like 120 kDa protein, mitochondrial	0	0	3	3
Eukaryotic translation initiation factor 5B	0	0	1	1
Rho-associated protein kinase 2	0	1	3	4
Serine/threonine-protein kinase ULK1	0	0	3	3
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	3	3
Ribosomal protein S6 kinase alpha-5	0	1	3	4
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	3	3
Ribosomal protein S6 kinase alpha-4	0	0	3	3
Serine/threonine-protein kinase 16	0	0	3	3
Cyclin-dependent kinase-like 5	0	0	2	2
Serine/threonine-protein kinase 10	0	0	3	3
Serine/threonine-protein kinase D3	0	0	3	3
Structural maintenance of chromosomes protein 2	0	0	2	2
Mitogen-activated protein kinase kinase kinase 6	0	0	3	3
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	3	3
Serine/threonine-protein kinase LATS1	0	0	3	3
Serine/threonine-protein kinase PAK 4	0	0	3	3
Tyrosine-protein kinase ABL1	0	1	4	5
High affinity nerve growth factor receptor	0	0	3	3
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	2	2
ADP/ATP translocase 2	0	0	3	3
Protein kinase C beta type	0	1	3	4
Insulin receptor	0	1	3	4
Tyrosine-protein kinase Lck	0	2	3	5
Tyrosine-protein kinase Fyn	0	3	3	6
Glycogen phosphorylase, liver form	0	0	3	3
Tyrosine-protein kinase Fes/Fps	0	0	3	3
Adenine phosphoribosyltransferase	0	0	2	2
Tyrosine-protein kinase Yes	0	1	3	4
Tyrosine-protein kinase Lyn	0	1	3	4
Proto-oncogene tyrosine-protein kinase receptor Ret	0	1	3	4
Insulin-like growth factor 1 receptor	0	0	3	3
Signal recognition particle receptor subunit alpha	0	0	3	3
Cytochrome c1, heme protein, mitochondrial	0	0	3	3
Hepatocyte growth factor receptor	0	0	3	3
Tyrosine-protein kinase HCK	0	1	3	4
Platelet-derived growth factor receptor beta	0	1	3	4
Tyrosine-protein kinase Fgr	0	1	2	3
Serine/threonine-protein kinase A-Raf	0	0	3	3
Glycogen phosphorylase, brain form	0	0	3	3
Breakpoint cluster region protein	0	0	3	3
Serine/threonine-protein kinase pim-1	0	0	3	3
Fibroblast growth factor receptor 1	0	1	3	4
Cyclin-dependent kinase 4	0	0	3	3
ADP/ATP translocase 3	0	0	3	3
Inosine-5'-monophosphate dehydrogenase 2	0	2	2	4
Proto-oncogene tyrosine-protein kinase Src	0	2	3	5
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	2	2
Serine/threonine-protein kinase B-raf	0	0	3	3
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	3	3
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	0	3	3
Tyrosine-protein kinase Fer	0	0	3	3
Protein kinase C alpha type	0	1	3	4
cAMP-dependent protein kinase catalytic subunit alpha	0	0	3	3
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	3	3
Casein kinase II subunit alpha'	0	0	3	3
Ras-related protein Rab-6A	0	0	3	3
Ephrin type-A receptor 1	0	0	3	3
Multifunctional protein ADE2	0	0	3	3
cAMP-dependent protein kinase catalytic subunit gamma	0	0	3	3
cAMP-dependent protein kinase catalytic subunit beta	0	0	3	3
Ferrochelatase, mitochondrial	0	0	3	3
Ribosomal protein S6 kinase beta-1	0	1	3	4
Tyrosine-protein kinase JAK1	0	5	4	11
Cyclin-dependent kinase 2	0	2	4	6
Beta-adrenergic receptor kinase 1	0	0	3	3
Probable ATP-dependent RNA helicase DDX6	0	0	3	3
Mitogen-activated protein kinase 3	0	0	3	3
MAP/microtubule affinity-regulating kinase 3	0	0	3	3
Phosphatidylinositol 3-kinase regulatory subunit alpha	0	1	0	1
Mitogen-activated protein kinase 1	0	1	3	4
Ephrin type-A receptor 2	0	1	3	4
Ephrin type-B receptor 2	0	0	3	3
Non-receptor tyrosine-protein kinase TYK2	0	3	4	9
Phosphatidylethanolamine-binding protein 1	0	0	2	2
Wee1-like protein kinase	0	0	3	3
Heme oxygenase 2	0	0	3	3
S-adenosylmethionine synthase isoform type-2	0	0	3	3
DnaJ homolog subfamily A member 1	0	0	3	3
RAC-alpha serine/threonine-protein kinase	0	1	3	4
RAC-beta serine/threonine-protein kinase	0	0	3	3
DNA replication licensing factor MCM4	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 2	0	1	3	4
Receptor-type tyrosine-protein kinase FLT3	0	2	3	5
Bone morphogenetic protein receptor type-1A	0	0	3	3
Activin receptor type-1B	0	0	3	3
TGF-beta receptor type-1	0	0	3	3
TGF-beta receptor type-2	0	0	3	3
Electron transfer flavoprotein subunit beta	0	0	1	1
Tyrosine-protein kinase CSK	0	2	3	5
Glycine--tRNA ligase	0	0	3	3
Protein kinase C iota type	0	0	3	3
Exosome RNA helicase MTR4	0	0	3	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	2	1	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	1	1	2
Serine/threonine-protein kinase mTOR	0	2	1	3
Phosphatidylinositol 4-kinase alpha	0	1	0	1
Tyrosine-protein kinase Tec	0	2	3	5
Tyrosine-protein kinase ABL2	0	0	3	3
Tyrosine-protein kinase FRK	0	1	3	4
G protein-coupled receptor kinase 6	0	0	2	2
Tyrosine-protein kinase SYK	0	1	3	4
26S proteasome regulatory subunit 6B	0	0	3	3
Mitogen-activated protein kinase 8	0	1	3	4
Mitogen-activated protein kinase 9	0	0	3	3
Dual specificity mitogen-activated protein kinase kinase 4	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 3	0	0	3	3
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	2	2
Casein kinase I isoform alpha	0	0	2	2
Casein kinase I isoform delta	0	0	3	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	1	2
MAP kinase-activated protein kinase 2	0	1	3	4
Elongation factor Tu, mitochondrial	0	0	3	3
Cysteine--tRNA ligase, cytoplasmic	0	0	2	2
Casein kinase I isoform epsilon	0	0	3	3
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	3	3
Dual specificity protein kinase CLK1	0	0	3	3
Dual specificity protein kinase CLK2	0	0	3	3
Glycogen synthase kinase-3 alpha	0	0	3	3
Glycogen synthase kinase-3 beta	0	1	3	4
Cyclin-dependent kinase 7	0	0	3	3
Cyclin-dependent kinase 9	0	0	3	3
Ras-related protein Rab-27A	0	0	2	2
Interleukin-1 receptor-associated kinase 1	0	0	3	3
Ribosomal protein S6 kinase alpha-3	0	1	3	4
Serine/threonine-protein kinase Nek2	0	0	3	3
Serine/threonine-protein kinase Nek3	0	0	3	3
Dual specificity mitogen-activated protein kinase kinase 6	0	0	3	3
Serine/threonine-protein kinase PLK1	0	0	3	3
LIM domain kinase 1	0	0	3	3
LIM domain kinase 2	0	0	3	3
Mitogen-activated protein kinase 10	0	0	3	3
Tyrosine--tRNA ligase, cytoplasmic	0	0	3	3
5'-AMP-activated protein kinase subunit gamma-1	0	0	3	3
Ephrin type-B receptor 3	0	0	3	3
Ephrin type-A receptor 5	0	0	3	3
Ephrin type-B receptor 4	0	0	3	3
Ephrin type-A receptor 4	0	0	3	3
Adenylate kinase 2, mitochondrial	0	0	3	4
Adenosine kinase	0	0	3	3
Ras-related protein Rab-10	0	0	3	3
Actin-related protein 3	0	0	3	3
Actin-related protein 2	0	0	2	2
GTP-binding nuclear protein Ran	0	0	3	3
Casein kinase I isoform gamma-2	0	0	3	3
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Cyclin-dependent kinase 3	0	0	3	3
Cyclin-dependent kinase 6	0	0	3	3
Cyclin-dependent-like kinase 5	0	1	3	4
Cyclin-dependent kinase 16	0	0	3	3
Cyclin-dependent kinase 17	0	0	3	3
ATP-dependent 6-phosphofructokinase, platelet type	0	0	3	3
Dual specificity mitogen-activated protein kinase kinase 1	0	0	3	3
Protein kinase C theta type	0	0	3	3
Activin receptor type-1	0	0	3	3
Macrophage-stimulating protein receptor	0	0	3	3
Focal adhesion kinase 1	0	0	3	3
Protein kinase C delta type	0	0	3	3
Tyrosine-protein kinase BTK	0	3	4	7
Activated CDC42 kinase 1	0	0	3	3
Epithelial discoidin domain-containing receptor 1	0	0	3	3
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	3	3
Serine/threonine-protein kinase 4	0	0	3	3
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	3	3
Dual specificity mitogen-activated protein kinase kinase 5	0	0	3	3
Mitogen-activated protein kinase 7	0	0	3	3
Serine/threonine-protein kinase PAK 2	0	0	3	3
Serine/threonine-protein kinase 3	0	0	3	3
Mitogen-activated protein kinase kinase kinase 1	0	0	3	3
Integrin-linked protein kinase	0	0	3	3
Rho-associated protein kinase 1	0	0	3	3
Non-receptor tyrosine-protein kinase TNK1	0	0	3	3
Serine/threonine-protein kinase ATR	0	0	2	2
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	3	3
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	3	3
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	3	3
Activin receptor type-2B	0	0	3	3
Bone morphogenetic protein receptor type-2	0	0	3	3
Protein-tyrosine kinase 6	0	1	3	4
cGMP-dependent protein kinase 1	0	0	3	3
Cyclin-dependent kinase 13	0	0	3	3
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	3	3
Protein-tyrosine kinase 2-beta	0	0	3	3
Maternal embryonic leucine zipper kinase	0	0	3	3
Structural maintenance of chromosomes protein 1A	0	0	2	2
Chromodomain-helicase-DNA-binding protein 4	0	0	3	3
Peroxisomal acyl-coenzyme A oxidase 1	0	0	1	1
Serine/threonine-protein kinase 38	0	0	3	3
Ephrin type-A receptor 7	0	0	3	3
Delta(24)-sterol reductase	0	0	2	2
Ribosomal protein S6 kinase alpha-1	0	1	3	4
Dual specificity testis-specific protein kinase 1	0	0	2	2
Myosin light chain kinase, smooth muscle	0	0	3	3
Mitogen-activated protein kinase 11	0	1	3	4
Serine/threonine-protein kinase STK11	0	0	3	3
Serine/threonine-protein kinase N1	0	0	3	3
Serine/threonine-protein kinase N2	0	0	3	3
Mitogen-activated protein kinase 14	0	2	3	5
Calcium/calmodulin-dependent protein kinase type IV	0	0	3	3
Mitogen-activated protein kinase kinase kinase 11	0	0	3	3
MAP kinase-activated protein kinase 3	0	0	2	2
Discoidin domain-containing receptor 2	0	0	3	3
AP2-associated protein kinase 1	0	0	3	3
Myosin light chain kinase 3	0	0	3	3
Uncharacterized aarF domain-containing protein kinase 5	0	0	2	2
Putative heat shock protein HSP 90-beta 2	0	0	3	3
Rab-like protein 3	0	0	3	3
Serine/threonine-protein kinase MRCK alpha	0	0	3	3
Serine/threonine-protein kinase MRCK gamma	0	0	3	3
Acyl-CoA dehydrogenase family member 10	0	0	3	3
Serine/threonine-protein kinase N3	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	3	3
Uncharacterized protein FLJ45252	0	0	3	3
Acyl-CoA dehydrogenase family member 11	0	0	2	2
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	3	3
Serine/threonine-protein kinase MARK2	0	0	3	3
ATP-dependent RNA helicase DHX30	0	0	3	3
Serine/threonine-protein kinase TAO1	0	0	3	3
STE20-related kinase adapter protein alpha	0	0	3	3
AarF domain-containing protein kinase 1	0	0	3	3
ATP-dependent RNA helicase DDX42	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	3	3
MAP kinase-activated protein kinase 5	0	1	3	4
Misshapen-like kinase 1	0	0	3	3
Phosphatidylinositol 3-kinase catalytic subunit type 3	0	1	0	1
Atypical kinase COQ8A, mitochondrial	0	0	3	3
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	3	3
Mitogen-activated protein kinase 15	0	0	3	3
Serine/threonine-protein kinase Nek9	0	0	3	3
ATP-dependent RNA helicase DDX1	0	0	3	3
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	3	3
MAP/microtubule affinity-regulating kinase 4	0	0	3	3
Serine/threonine-protein kinase Nek1	0	0	3	3
PAS domain-containing serine/threonine-protein kinase	0	0	3	3
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	3	3
EKC/KEOPS complex subunit TP53RK	0	0	3	3
Dual specificity testis-specific protein kinase 2	0	0	2	2
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	3	3
Mitogen-activated protein kinase kinase kinase 5	0	0	3	3
Mitogen-activated protein kinase kinase kinase 3	0	0	3	3
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	3	3
Nucleolar GTP-binding protein 1	0	0	3	3
Serine/threonine-protein kinase D2	0	0	3	3
NUAK family SNF1-like kinase 2	0	0	3	3
RNA cytidine acetyltransferase	0	0	3	3
Serine/threonine-protein kinase SIK2	0	0	3	3
STE20-like serine/threonine-protein kinase	0	0	3	3
Serine/threonine-protein kinase TAO3	0	0	3	3
dCTP pyrophosphatase 1	0	0	3	3
Dual specificity protein kinase CLK4	0	0	3	3
Casein kinase I isoform gamma-1	0	0	3	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
Serine/threonine-protein kinase PAK 6	0	0	3	3
Phenylalanine--tRNA ligase beta subunit	0	0	3	3
BMP-2-inducible protein kinase	0	0	3	3
Midasin	0	0	3	3
Interleukin-1 receptor-associated kinase 4	0	0	3	3
Mitogen-activated protein kinase kinase kinase 20	0	0	3	3
Cyclin-dependent kinase 12	0	0	3	3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	3	3
Serine/threonine-protein kinase 26	0	0	3	3
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	3	3
Serine/threonine-protein kinase NLK	0	0	3	3
Phosphatidylinositol 4-kinase beta	0	1	1	2
5'-AMP-activated protein kinase subunit gamma-2	0	0	3	3
Serine/threonine-protein kinase TBK1	0	1	3	4
Septin-9	0	0	3	3
Ribosomal protein S6 kinase alpha-6	0	0	3	3
TRAF2 and NCK-interacting protein kinase	0	0	3	3
Serine/threonine-protein kinase TAO2	0	0	3	3
Long-chain-fatty-acid--CoA ligase 5	0	0	2	2
Serine/threonine-protein kinase ICK	0	0	3	3
RAC-gamma serine/threonine-protein kinase	0	0	3	3
Serine/threonine-protein kinase 38-like	0	0	2	2
Serine/threonine-protein kinase SIK3	0	0	3	3
Mitogen-activated protein kinase kinase kinase 2	0	0	3	3
Thyroid hormone receptor-associated protein 3	0	0	3	3
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	3	3
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	3	3
Receptor-interacting serine/threonine-protein kinase 3	0	0	3	3
Serine/threonine-protein kinase MRCK beta	0	0	3	3
Interleukin-1 receptor-associated kinase 3	0	0	3	3
Serine/threonine-protein kinase 24	0	0	3	3
Casein kinase I isoform gamma-3	0	0	3	3
Mitogen-activated protein kinase kinase kinase 4	0	0	3	3
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
N-glycosylase/DNA lyase	0	1	0	1
Polyphenol oxidase 2	0	3	0	4
Formamidopyrimidine-DNA glycosylase	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Macrophage migration inhibitory factor	0	2	0	2
Endonuclease III-like protein 1	0	1	0	1
DNA gyrase subunit B	0	2	0	2
DNA gyrase subunit A	0	2	0	2
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Endonuclease 8-like 1	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
Hsf1 protein	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Capsid protein	0	1	2	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Chain A, protease	0	1	0	1
Chain B, protease	0	1	0	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, PROTEASE RETROPEPSIN	0	1	0	1
Chain B, PROTEASE RETROPEPSIN	0	1	0	1
Chain A, Protease Retropepsin	0	1	0	1
Chain B, Protease Retropepsin	0	1	0	1
Chain A, Protease Retropepsin	0	1	0	1
Chain B, Protease Retropepsin	0	1	0	1
Gag-Pol polyprotein	0	2	0	2
Gag-Pol polyprotein	0	2	0	2
Gag-Pol polyprotein	0	2	0	2
CAAX prenyl protease 1 homolog	0	1	0	1
Plasmepsin V	0	2	0	2
C-C chemokine receptor type 5	0	1	2	4
C-C chemokine receptor type 5	0	1	0	1
C-C chemokine receptor type 5	0	1	0	1
Multidrug and toxin extrusion protein 2	0	2	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	1	2
Metallo-beta-lactamase VIM-11	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
lethal factor (plasmid)	3	0	0	3
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	1	2
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Histamine H3 receptor	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase VIM-1	0	0	0	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
cytochrome P450 2C19 precursor	2	0	0	2
microphthalmia-associated transcription factor isoform 9	0	1	0	1
caspase-1 isoform alpha precursor	2	0	0	2
Tumor necrosis factor	0	1	1	2
Neuraminidase	0	1	0	1
Platelet-activating factor receptor	1	0	0	1
Cystathionine gamma-lyase	0	1	0	1
Caspase-7	2	0	0	2
Cystine/glutamate transporter	0	2	0	2
Hydroxyacid oxidase 1	0	1	0	1
large T antigen	0	1	0	1
Dopamine beta-hydroxylase	0	2	0	2
Lactoperoxidase	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
acid sphingomyelinase	2	0	0	2
dopamine D1 receptor	2	0	0	2
Thymidylate synthase	0	1	0	1
alpha-galactosidase	5	0	0	5
Thymidylate synthase	0	1	0	1
cellular tumor antigen p53 isoform a	4	0	0	4
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
flap endonuclease 1	4	0	0	4
DNA polymerase eta isoform 1	3	0	0	3
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	3	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	4	3	8
Bifunctional dihydrofolate reductase-thymidylate synthase	0	3	0	3
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	3	0	3
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Pteridine reductase 1	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	5	5
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
5-hydroxytryptamine receptor 3E	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
D(1A) dopamine receptor	2	0	0	2
huntingtin isoform 2	1	0	0	1
ras-related protein Rab-9A	2	0	0	2
5-hydroxytryptamine receptor 4	0	2	0	2
5-hydroxytryptamine receptor 3B	0	1	0	1
Aldo-keto reductase family 1 member B1	0	6	0	6
5-hydroxytryptamine receptor 1A	0	3	3	6
Muscarinic acetylcholine receptor M5	0	1	0	1
D(2) dopamine receptor	0	3	0	3
D	0	2	0	2
D(3) dopamine receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	2	1	3
Endothelin receptor type B	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
D(4) dopamine receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	1	3
Alpha-2A adrenergic receptor	0	2	1	3
Sodium-dependent noradrenaline transporter	0	6	0	6
5-hydroxytryptamine receptor 3A	0	2	0	2
Endothelin receptor type B	0	2	0	2
Histamine H2 receptor	0	2	0	2
Endothelin-1 receptor	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 2A	0	5	0	5
5-hydroxytryptamine receptor 2C	0	5	0	5
5-hydroxytryptamine receptor 1B	0	2	0	2
5-hydroxytryptamine receptor 1D	0	2	0	2
5-hydroxytryptamine receptor 1F	0	2	0	2
5-hydroxytryptamine receptor 6	0	1	0	1
Histamine H1 receptor	0	1	0	1
Sodium-dependent serotonin transporter	0	2	0	2
5-hydroxytryptamine receptor 7	0	3	0	3
5-hydroxytryptamine receptor 7	0	4	0	4
Alpha-1A adrenergic receptor	0	2	0	2
Type-2 angiotensin II receptor	0	3	0	3
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
Histamine H1 receptor	0	3	0	3
D(3) dopamine receptor	0	5	0	5
5-hydroxytryptamine receptor 3A	0	2	0	2
5-hydroxytryptamine receptor 2B	0	5	0	5
5-hydroxytryptamine receptor 3A	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
Inositol monophosphatase 1	2	0	0	2
5-hydroxytryptamine receptor 4	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
5-hydroxytryptamine receptor 3B	0	2	0	2
5-hydroxytryptamine receptor 3B	0	2	0	2
G-protein coupled receptor	0	1	0	1
Transporter	0	4	0	4
Sodium-dependent dopamine transporter	0	1	0	1
Beta-2 adrenergic receptor	0	2	0	2
Adenosine receptor A3	0	2	0	2
Beta-3 adrenergic receptor	0	2	0	2
Substance-K receptor	0	6	0	6
Thromboxane-A synthase	0	3	0	3
Delta-type opioid receptor	0	4	0	4
Sodium-dependent dopamine transporter	0	2	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	2	0	2
Leukotriene C4 synthase	0	1	0	1
Cysteinyl leukotriene receptor 1	0	1	0	1
Cysteinyl leukotriene receptor 2	0	1	0	1
Cysteinyl leukotriene receptor 1	0	2	1	3
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
Inosine-5'-monophosphate dehydrogenase 1	0	2	0	2
Peroxisome proliferator-activated receptor gamma	0	0	3	3
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A8	0	0	0	1
Chain B, Hiv-1 Reverse Transcriptase	0	1	0	1
Chain A, Hiv-1 Reverse Transcriptase	0	1	0	1
Chain A, Hiv-1 Reverse Transcriptase	0	1	0	1
Chain A, Hiv-1 Reverse Transcriptase	0	1	0	1
Chain B, Hiv-1 Reverse Transcriptase	0	1	0	1
Chain A, Reverse transcriptase/ribonuclease H	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Imidazoleglycerol-phosphate dehydratase	0	1	0	1
Ryanodine receptor 1	0	1	0	1
Exoribonuclease H	0	1	0	1
Cardiac ryanodine receptor 2	0	1	0	1
Genome polyprotein	0	1	0	1
pregnane X receptor	3	0	0	3
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
Tubulin alpha-1A chain	0	0	1	2
Tubulin beta chain	0	0	1	1
Tubulin beta-4A chain	0	1	1	3
Receptor tyrosine-protein kinase erbB-2	0	3	2	5
Integrin alpha-V	0	1	0	1
Tubulin beta chain	0	1	1	3
Tubulin alpha-3C chain	0	1	1	3
Botulinum neurotoxin type A	0	1	0	1
Apoptosis regulator Bcl-2	0	1	0	1
Cholecystokinin receptor type A	0	2	0	2
Melanocortin receptor 5	0	2	0	2
Tubulin alpha-1B chain	0	1	1	3
Tubulin alpha-4A chain	0	1	1	3
Tubulin beta-4B chain	0	1	1	3
Bcl-2-like protein 1	0	1	0	1
Tyrosine-protein kinase Mer	0	1	2	3
Tubulin beta-3 chain	0	2	1	4
Tubulin beta-2A chain	0	1	1	3
Beta-tubulin	0	1	0	1
Tubulin beta-8 chain	0	1	1	3
Tubulin alpha-3E chain	0	1	1	3
Tubulin alpha-1A chain	0	1	1	3
Tubulin alpha-1C chain	0	1	1	3
Tubulin beta-6 chain	0	1	1	3
Tubulin beta-2B chain	0	1	1	3
Tubulin beta-1 chain	0	1	1	3
Nucleotide-binding oligomerization domain-containing protein 2	0	1	0	1
tyrosine-protein kinase Yes	3	0	0	3
Cell division cycle 7-related protein kinase	0	0	1	1
Testosterone 17-beta-dehydrogenase 3	0	1	0	1
Putative nucleoside diphosphate kinase	0	0	1	1
Tyrosine-protein kinase JAK2	0	5	2	9
Solute carrier family 22 member 3	0	2	0	2
Macrophage colony-stimulating factor 1 receptor	0	1	1	2
Receptor tyrosine-protein kinase erbB-3	0	1	1	2
Nucleoside diphosphate kinase B	0	0	1	1
G1/S-specific cyclin-E1	0	1	0	1
Dual specificity protein kinase TTK	0	0	2	2
Myosin-10	0	0	1	1
Tyrosine-protein kinase TXK	0	2	2	4
Choline-phosphate cytidylyltransferase A	0	0	1	1
Tyrosine-protein kinase Blk	0	2	2	4
Cytoplasmic tyrosine-protein kinase BMX	0	3	2	5
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	2	2
Tyrosine-protein kinase JAK3	0	4	3	10
Tyrosine-protein kinase ITK/TSK	0	2	2	4
Receptor tyrosine-protein kinase erbB-4	0	2	2	4
Myosin-14	0	0	2	2
Serine/threonine-protein kinase Nek7	0	0	2	2
Nuclear receptor subfamily 4 group A member 3	0	1	0	1
Calcium/calmodulin-dependent protein kinase type 1G	0	0	2	2
Peroxiredoxin-like 2A	0	1	0	1
Platelet glycoprotein VI	0	1	0	1
Obg-like ATPase 1	0	0	1	1
Adenosine deaminase	0	1	0	1
Adenosine deaminase	0	1	0	1
Adenosine deaminase	0	1	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Gamma-aminobutyric acid	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
muscarinic acetylcholine receptor M1	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Sterol 14-alpha-demethylase	0	0	2	2
14-alpha sterol demethylase	0	0	2	2
14-alpha sterol demethylase	0	0	2	2
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b	0	0	1	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	1	1	2
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
thioredoxin glutathione reductase	4	0	0	4
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
dual specificity protein phosphatase 3	0	1	0	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
tyrosine-protein phosphatase non-receptor type 22 isoform 1	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Beta-hexosaminidase subunit alpha	0	1	0	2
Beta-hexosaminidase subunit beta	0	1	0	1
Substance-K receptor	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Multidrug and toxin extrusion protein 1	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Arylacetamide deacetylase	0	1	0	2
Glutathione S-transferase omega-1	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Reverse transcriptase	0	1	0	1
DNA polymerase III, partial	1	0	0	1
ubiquitin-conjugating enzyme E2 N	0	2	0	2
pyruvate kinase PKM isoform b	1	0	0	1
Ornithine decarboxylase	1	0	0	1
Diacylglycerol kinase alpha	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Guanine nucleotide-binding protein G	1	0	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Chain A, HIV-1 PROTEASE	0	1	0	1
Chain B, HIV-1 PROTEASE	0	1	0	1
Chain A, POL polyprotein	0	1	0	1
Chain B, POL polyprotein	0	1	0	1
Chain A, POL polyprotein	0	1	0	1
Chain B, POL polyprotein	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
Cytochrome P450 3A5	0	3	0	3
Mu-type opioid receptor	0	2	0	2
Vasopressin V1a receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Thromboxane-A synthase	0	0	0	1
Sodium/bile acid cotransporter	0	2	0	2
C-X-C chemokine receptor type 5 isoform 1	0	1	0	1
C-C chemokine receptor type 6	0	1	0	1
apelin receptor	0	1	0	1
bcl-2-related protein A1	0	1	0	1
Endoglycoceramidase II	0	0	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Protein kinase C eta type	0	1	0	1
Protein kinase C theta type	0	1	0	1
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
Thymidine kinase, cytosolic	0	1	0	2
Chain A, Glutathione S-transferase	0	1	0	1
histone deacetylase 9 isoform 3	1	0	0	1
Interstitial collagenase	0	1	0	1
Fibroblast growth factor 1	0	0	1	1
Flavin reductase (NADPH)	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Adenylate kinase isoenzyme 1	0	0	0	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
C-8 sterol isomerase	0	1	0	1
Squalene monooxygenase	0	1	0	1
Squalene monooxygenase	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	2	1	3
Stromal interaction molecule 1	0	1	0	1
Dihydroorotate dehydrogenase	0	2	0	2
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Calcium release-activated calcium channel protein 1	0	1	0	1
Cereblon isoform 4	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Chain A, Tyrosine-protein kinase	0	1	0	1
Chain A, Tyrosine-protein kinase	0	1	0	1
Chain A, Tyrosine-protein kinase JAK2	0	1	0	1
Leukotriene C4 synthase	0	0	1	1
Serine/threonine-protein kinase Sgk1	0	1	0	1
Serine/threonine-protein kinase 25	0	0	1	1
Serine/threonine-protein kinase RIO3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 7	0	1	1	2
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	1	1
Peripheral plasma membrane protein CASK	0	0	1	1
Serine/threonine-protein kinase DCLK1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	1	1
Muscle, skeletal receptor tyrosine-protein kinase	0	0	1	1
Mitogen-activated protein kinase 13	0	1	1	2
3-phosphoinositide-dependent protein kinase 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 13	0	0	1	1
Death-associated protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
NUAK family SNF1-like kinase 1	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	1	1
Serine/threonine-protein kinase PAK 3	0	0	1	1
Serine/threonine-protein kinase 17B	0	0	1	1
Cyclin-dependent kinase 14	0	0	1	1
Serine/threonine-protein kinase OSR1	0	0	1	1
Serine/threonine-protein kinase Chk2	0	0	1	1
RAF proto-oncogene serine/threonine-protein kinase	0	0	1	1
Proto-oncogene tyrosine-protein kinase ROS	0	0	1	1
Wee1-like protein kinase 2	0	0	1	1
Uncharacterized serine/threonine-protein kinase SBK3	0	0	1	1
Mast/stem cell growth factor receptor Kit	0	0	1	1
Myosin light chain kinase, smooth muscle	0	0	1	1
Insulin receptor-related protein	0	0	1	1
Platelet-derived growth factor receptor alpha	0	0	1	1
Vascular endothelial growth factor receptor 1	0	0	1	1
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	1	1
Serine/threonine-protein kinase MAK	0	0	1	1
Cyclin-dependent kinase 11B	0	0	1	1
Fibroblast growth factor receptor 2	0	0	1	1
Fibroblast growth factor receptor 4	0	0	1	1
Fibroblast growth factor receptor 3	0	0	1	1
Protein kinase C eta type	0	0	1	1
Activin receptor type-2A	0	0	1	1
Ephrin type-A receptor 3	0	0	1	1
Ephrin type-A receptor 8	0	0	1	1
Leukocyte tyrosine kinase receptor	0	0	1	1
Tyrosine-protein kinase receptor UFO	0	0	1	1
Mitogen-activated protein kinase 4	0	0	1	1
G protein-coupled receptor kinase 4	0	0	1	1
Tyrosine-protein kinase receptor Tie-1	0	0	1	1
Vascular endothelial growth factor receptor 3	0	0	1	1
Vascular endothelial growth factor receptor 2	0	0	1	1
Serine/threonine-protein kinase receptor R3	0	0	1	1
Megakaryocyte-associated tyrosine-protein kinase	0	0	1	1
Tyrosine-protein kinase ZAP-70	0	0	1	1
Cyclin-dependent kinase 8	0	0	1	1
Dual specificity protein kinase CLK3	0	0	1	1
Serine/threonine-protein kinase Nek4	0	0	1	1
Death-associated protein kinase 1	0	0	1	1
Mitogen-activated protein kinase 12	0	1	1	2
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	1
Ephrin type-B receptor 1	0	0	1	1
Hormonally up-regulated neu tumor-associated kinase	0	0	1	1
Serine/threonine-protein kinase SIK1	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 4	0	0	1	1
Cell division control protein 2 homolog	0	0	1	1
Calcium-dependent protein kinase 1	0	0	1	1
Tubulin alpha-1A chain	0	0	1	1
Casein kinase II subunit alpha	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	1	1
SRSF protein kinase 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 9	0	0	1	1
Serine/threonine-protein kinase PknB	0	0	1	1
Cyclin-dependent kinase-like 1	0	0	1	1
Protein kinase C epsilon type	0	1	1	2
Angiopoietin-1 receptor	0	0	1	1
Mitogen-activated protein kinase kinase kinase 10	0	0	1	1
Tyrosine-protein kinase receptor TYRO3	0	0	1	1
Cyclin-dependent kinase 18	0	0	1	1
Myotonin-protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 12	0	0	1	1
Serine/threonine-protein kinase PAK 1	0	0	1	1
cGMP-dependent protein kinase 2	0	0	1	1
Serine/threonine-protein kinase PRP4 homolog	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1	0	0	1	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0	1	0	1
Serine/threonine-protein kinase D1	0	0	1	1
Ribosomal protein S6 kinase alpha-2	0	0	1	1
Rhodopsin kinase GRK1	0	0	1	1
NT-3 growth factor receptor	0	0	1	1
BDNF/NT-3 growth factors receptor	0	0	1	1
Mitogen-activated protein kinase 6	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	1	1
Serine/threonine-protein kinase SBK1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 19	0	0	1	1
Serine/threonine-protein kinase TNNI3K	0	0	1	1
Tyrosine-protein kinase JAK3	0	1	0	1
Tyrosine-protein kinase JAK2	0	1	0	1
Tyrosine-protein kinase JAK3	0	1	0	1
Serine/threonine-protein kinase Nek5	0	0	1	1
Dual serine/threonine and tyrosine protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 15	0	0	1	1
Serine/threonine-protein kinase tousled-like 2	0	0	1	1
Serine/threonine-protein kinase 32C	0	0	1	1
Serine/threonine-protein kinase pim-3	0	0	1	1
Serine/threonine-protein kinase VRK2	0	0	1	1
Myosin light chain kinase family member 4	0	0	1	1
Homeodomain-interacting protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1D	0	0	1	1
Cyclin-dependent kinase-like 3	0	0	1	1
Serine/threonine-protein kinase BRSK2	0	0	1	1
Serine/threonine-protein kinase NIM1	0	0	1	1
Serine/threonine-protein kinase ULK2	0	0	1	1
Serine/threonine-protein kinase DCLK2	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	1	1
Casein kinase I isoform alpha-like	0	0	1	1
Homeodomain-interacting protein kinase 4	0	0	1	1
Myosin-IIIa	0	0	1	1
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	1	1
Serine/threonine-protein kinase Nek11	0	0	1	1
Serine/threonine-protein kinase BRSK1	0	0	1	1
Serine/threonine-protein kinase 35	0	0	1	1
Rhodopsin kinase GRK7	0	0	1	1
Serine/threonine-protein kinase 32A	0	0	1	1
Myosin-IIIb	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	1	1
Cyclin-dependent kinase-like 2	0	0	1	1
Serine/threonine-protein kinase Sgk3	0	0	1	1
Atypical kinase COQ8B, mitochondrial	0	0	1	1
Cyclin-dependent kinase 15	0	0	1	1
SRSF protein kinase 1	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	1	1
Serine/threonine-protein kinase RIO1	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase RIO2	0	0	1	1
Cyclin-dependent kinase 19	0	0	1	1
Transient receptor potential cation channel subfamily M member 6	0	0	1	1
Testis-specific serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase 33	0	0	1	1
Serine/threonine-protein kinase DCLK3	0	0	1	1
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	1	1
Homeodomain-interacting protein kinase 2	0	0	1	1
Tyrosine-protein kinase Srms	0	0	1	1
Homeodomain-interacting protein kinase 3	0	0	1	1
Serine/threonine-protein kinase PLK3	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 2	0	0	1	1
Serine/threonine-protein kinase Nek6	0	0	1	1
SNF-related serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase LATS2	0	0	1	1
Serine/threonine-protein kinase 36	0	0	1	1
Serine/threonine-protein kinase 32B	0	0	1	1
Serine/threonine-protein kinase PLK2	0	0	1	1
Serine/threonine-protein kinase MARK1	0	0	1	1
Serine/threonine-protein kinase pim-2	0	0	1	1
Serine/threonine-protein kinase PAK 5	0	0	1	1
eIF-2-alpha kinase GCN2	0	0	1	1
Serine/threonine-protein kinase 17A	0	0	1	1
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	1	1
Ephrin type-A receptor 6	0	0	1	1
Death-associated protein kinase 2	0	0	1	1
Serine/threonine-protein kinase tousled-like 1	0	0	1	1
ALK tyrosine kinase receptor	0	0	1	1
SRSF protein kinase 3	0	0	1	1
Cyclin-dependent kinase 11A	0	0	1	1
Aurora kinase C	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	1	1
Microtubule-associated serine/threonine-protein kinase 1	0	0	1	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
Plasma kallikrein	0	0	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Stromelysin-1	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Tryptophan 2,3-dioxygenase	0	1	0	2
Large neutral amino acids transporter small subunit 1	0	2	0	2
SLC16A10 protein	0	0	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Monocarboxylate transporter 10	0	0	0	1
Phospholipase A-2-activating protein	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Valacyclovir hydrolase	0	0	0	1
Chain A, Arginase 1	0	1	0	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	0	1	1
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
pyruvate kinase PKM isoform a	1	0	0	1
Ectonucleoside triphosphate diphosphohydrolase 1	0	0	0	1
DNA polymerase beta	0	1	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Solute carrier family 22 member 7	0	0	0	1
Thymidine kinase	0	1	0	2
Solute carrier family 22 member 7	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Immune Reconstitution Disease

Synonyms(5)

Research Excerpts

Overview

Context

Treatment

Research

Studies (333)

Protein Targets (1,696)

Immune Reconstitution Disease

Synonyms(5)

Research Excerpts

Overview

Context

Treatment

Research

Studies (333)

Drugs Studied (136)

Protein Targets (1,696)