| Assay ID | Title | Year | Journal | Article |
|---|
| AID459330 | Inhibition of SHP2-dependent ERK1/2 activation in EGF-stimulated mouse NIH/3T3 cells assessed as phosphorylated ERK1/2 level at 10 uM treated for 3 hrs before EGF challenge measured after 5 to 15 mins of EGF stimulation by immunoblot analysis | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6
| Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). |
| AID459329 | Inhibition of SHP2-dependent ERK1/2 activation in EGF-stimulated mouse NIH/3T3 cells assessed as phosphorylated ERK1/2 level at 10 uM treated for 3 hrs before EGF challenge measured after 60 mins of EGF stimulation by immunoblot analysis | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6
| Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). |
| AID459321 | Inhibition of CD45 expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6
| Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). |
| AID1866108 | Inhibition of SHP2 (unknown origin) | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Strategies Targeting Protein Tyrosine Phosphatase SHP2 for Cancer Therapy. |
| AID459338 | Selectivity ratio of IC50 for SHP2 K364R mutant to IC50 for SHP2 Src homology-2 domain | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6
| Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). |
| AID459340 | Ratio of 3-ethynyl-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid IC50 to compound IC50 for SHP2 Src homology-2 domain | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6
| Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). |
| AID459334 | Antiproliferative activity against GM-CSF-stimulated C57/BL6 mouse low density BM-MNC expressing SHP2 E76K mutant assessed as inhibition of hyperproliferation at 10 uM after 16 hrs by [3H]thymidine incorporation assay | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6
| Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). |
| AID653546 | Inhibition of SHP2 expressed in Escherichia coli BL21 (DE3) cells using pNPP as substrate by spectrophotometric analysis | 2012 | Bioorganic & medicinal chemistry, Mar-15, Volume: 20, Issue:6
| Bicyclic benzofuran and indole-based salicylic acids as protein tyrosine phosphatase inhibitors. |
| AID459333 | Antiproliferative activity against GM-CSF-stimulated C57/BL6 mouse low density BM-MNC expressing wild type SHP2 assessed as inhibition of hyperproliferation at 10 uM after 16 hrs by [3H]thymidine incorporation assay | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6
| Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). |
| AID459317 | Inhibition of PTP1B expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6
| Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). |
| AID1182573 | Anticancer activity against mouse 32D cells bearing wild-type KIT assessed as ligand dependent growth inhibition at 1 to 5 uM measured after 6 hrs | 2014 | Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15
| Therapeutic potential of targeting the oncogenic SHP2 phosphatase. |
| AID459336 | Inhibition of SHP2 K364R mutant expressed in Escherichia coli BL21 (DE3) assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6
| Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). |
| AID1706915 | Inhibition of recombinant SHP2 (262 to 532 amino acids) (unknown origin) incubated for 1 hr using 10 uM DiFMUP by DiFMUP assay | 2020 | Journal of medicinal chemistry, 12-10, Volume: 63, Issue:23
| From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement. |
| AID459314 | Inhibition of SHP2 Src homology-2 domain expressed in Escherichia coli BL21 (DE3) assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6
| Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). |
| AID459327 | Inhibition of SHP2-dependent ERK1/2 activation in EGF-stimulated HEK293 cells assessed as phosphorylated ERK1/2 level at 10 uM treated for 3 hrs before EGF challenge measured after 60 mins of EGF stimulation by immunoblot analysis | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6
| Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). |
| AID1631774 | Inhibition of human 6his-tagged SHP2 (2 to 593 residues) expressed in Escherichia coli BL21 Star (DE3) cells preincubated with IRS1_pY1172(dPEG8)pY1222 for 30 to 60 mins followed by addition of DiFMUP measured after 30 mins by fluorescence analysis | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17
| Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor. |
| AID1182575 | Anticancer activity against mouse 32D cells bearing KITD814V mutant assessed as ligand dependent growth inhibition at 1 uM measured after 6 hrs | 2014 | Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15
| Therapeutic potential of targeting the oncogenic SHP2 phosphatase. |
| AID1182574 | Anticancer activity against mouse 32D cells bearing KITD814V mutant assessed as ligand dependent growth inhibition at 5 uM measured after 6 hrs | 2014 | Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15
| Therapeutic potential of targeting the oncogenic SHP2 phosphatase. |
| AID459323 | Inhibition of PTPalpha expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6
| Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). |
| AID459331 | Inhibition of SHP2-dependent ERK1/2 activation in EGF-stimulated HEK293 cells assessed as phosphorylated ERK1/2 level treated for 3 hrs before EGF challenge measured after 60 mins of EGF stimulation by immunoblot analysis | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6
| Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). |
| AID459337 | Inhibition of SHP2 K364S mutant expressed in Escherichia coli BL21 (DE3) assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6
| Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). |
| AID459328 | Inhibition of SHP2-dependent ERK1/2 activation in EGF-stimulated HEK293 cells assessed as phosphorylated ERK1/2 level at 10 uM treated for 3 hrs before EGF challenge measured after 5 to 15 mins of EGF stimulation by immunoblot analysis | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6
| Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). |
| AID459335 | Antiproliferative activity against GM-CSF-stimulated C57/BL6 mouse low density BM-MNC expressing SHP2 D61Y mutant assessed as inhibition of hyperproliferation at 10 uM after 16 hrs by [3H]thymidine incorporation assay | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6
| Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). |
| AID459324 | Inhibition of VHR expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6
| Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). |
| AID459326 | Inhibition of LMWPTP expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6
| Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). |
| AID459316 | Inhibition of SHP1 expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6
| Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). |
| AID459325 | Inhibition of Cdc14A expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6
| Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). |
| AID459322 | Inhibition of LAR expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6
| Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). |
| AID459318 | Inhibition of HePTP expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6
| Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). |
| AID459319 | Inhibition of Lyp expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6
| Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). |
| AID459339 | Selectivity ratio of IC50 for SHP2 K364S mutant to IC50 for SHP2 Src homology-2 domain | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6
| Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). |
| AID459315 | Inhibition of SHP2 Src homology-2 domain expressed in Escherichia coli BL21 (DE3) assessed as inhibition of p-nitrophenyl phosphate hydrolysis by Lineweaver-Burke plot analysis | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6
| Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). |
| AID1706914 | Inhibition of recombinant SHP2 (262 to 532 amino acids) (unknown origin) incubated for 1 hr using 20 uM DiFMUP by DiFMUP assay | 2020 | Journal of medicinal chemistry, 12-10, Volume: 63, Issue:23
| From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement. |
| AID459320 | Inhibition of FAP1 expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6
| Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |