Compounds > triasulfuron
Page last updated: 2024-12-06

triasulfuron

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Description

Triasulfuron is a sulfonylurea herbicide used to control broadleaf weeds in cereal crops, turf, and other non-crop areas. It is a selective herbicide, meaning it primarily targets broadleaf weeds while sparing the desired crop plants. Triasulfuron inhibits the enzyme acetolactate synthase (ALS), an essential enzyme in the biosynthesis of branched-chain amino acids, which are vital for plant growth. By blocking this enzyme, triasulfuron disrupts the growth and development of susceptible weeds. Triasulfuron is absorbed through the roots and leaves of weeds, and it is translocated throughout the plant. It is a systemic herbicide, meaning it can kill weeds even if only a portion of the plant is exposed. Triasulfuron is a relatively persistent herbicide in the soil, with a half-life of several months. This persistence can be beneficial for long-term weed control, but it also means that triasulfuron can potentially accumulate in the soil and have negative impacts on non-target organisms. The research on triasulfuron is driven by its effectiveness as a weed control agent, as well as its potential environmental impacts. Scientists are studying the effects of triasulfuron on soil microbial communities, aquatic organisms, and other non-target species. They are also investigating the persistence of triasulfuron in the environment and the development of resistant weed populations. Triasulfuron is a valuable tool for weed control, but it is important to use it responsibly and to minimize its potential negative impacts on the environment.'

triasulfuron : An N-sulfonylurea that is N-[o-(2-chloroethoxy)phenyl]sulfonylurea in which one of the hydrogens attached to the non-sulfonylated nitrogen has been replaced by a 4-methoxy-6-methyl-1,3,5-triazin-2-yl group. A herbicide used to control broad-leaved weeds in cereals, its use within the EU has been banned after September 2017 on the grounds of potential groundwater contamination and risks to aquatic life. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID73282
CHEMBL ID1896787
CHEBI ID9673
SCHEMBL ID24021
MeSH IDM0247797

Synonyms (41)

Synonym
AC-14071
1-[2-(2-chloroethoxy)phenyl]sulfonyl-3-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)urea
triasulphuron
benzenesulfonamide, 2-(2-chloroethoxy)-n-(((4-methoxy-6-methyl-1,3,5-triazin-2-yl)ami-no)carbonyl)-
logran
1-(2-(2-chloroethoxy)phenylsulfonyl)-3-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)urea (iupac)
cga 131036
epa pesticide chemical code 128969
benzenesulfonamide, 2-(2-chloroethoxy)-n-(((4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino)carbonyl)-
2-(2-chloroethoxy)-n-(((4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino)carbonyl)benzenesulfonamide
triasulfuron [iso]
triasulfuron
82097-50-5
2-(2-chloroethoxy)-n-{[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}benzenesulfonamide
NCGC00168340-01
NCGC00168340-02
dtxsid0024345 ,
NCGC00258752-01
dtxcid204345
cas-82097-50-5
tox21_201200
hsdb 8436
unii-299lhf498m
299lhf498m ,
FT-0630900
AKOS015897330
triasulfuron [mi]
1-(2-(2-chloroethoxy)phenylsulfonyl)-3-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)urea
cga-131036
SCHEMBL24021
KS-5284
CHEMBL1896787
chebi:9673 ,
1-[2-(2-chloroethoxy)phenylsulfonyl]-3-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)urea
2-(2-chloroethoxy)-n-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]benzenesulfonamide
2-(2-chloroethoxy)-n-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamoyl]benzenesulfonamide
triasulfuron, pestanal(r), analytical standard
2-(2-chloroethoxy)-n-(4-methoxy-6-methyl-1,3,5-triazin-2-ylcarbamoyl)benzenesulfonamide
1-{[2-(2-chloroethoxy)benzene]sulfonyl}-3-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)urea
mfcd00145436
Q2384787

Research Excerpts

Overview

Triasulfuron is a widely used sulfonylurea herbicide. It inhibits the acetolactate synthase in broad-leaf weeds and in some wheat crop grasses.

ExcerptReferenceRelevance
"Triasulfuron (TS) is a widely used sulfonylurea herbicide which inhibits the acetolactate synthase in broad-leaf weeds and in some wheat crop grasses (Triticum aestivum L.). "( Genotoxicity of triasulfuron in the wing spot test of Drosophila melanogaster is modulated by winter wheat seedlings.
Castañeda-Partida, L; Dueñas-García, I; Durán-Díaz, A; Flores-Maya, S; Graf, U; Heres-Pulido, ME; Lombera-Hernández, S; Perales-Canales, I; Rocha-Ortiz, C, 2008)		2.13

Toxicity

ExcerptReferenceRelevance
" For these organisms, triasulfuron photoproducts were less toxic than the parent compound but the residual toxicity observed still represented a potential environmental hazard."( Assessment of the toxicity of triasulfuron and its photoproducts using aquatic organisms.
Chouteau, C; Chovelon, JM; Clement, B; Emmelin, C; Vulliet, E, 2004)		0.93

Dosage Studied

ExcerptRelevanceReference
" Cross resistance of HB08 and HB16 to AHAS herbicides of SU, imidazolinone (IMI), triazolopyrimidine (TP) and pyrimidinyl-thiobenozoate (PTB) families was investigated by dose-response experiments."( Different cross-resistance patterns to AHAS herbicides of two tribenuron-methyl resistant flixweed (Descurainiasophia L.) biotypes in China.
Cao, Y; Deng, W; Liu, MJ; Mei, Y; Yang, Q; Zheng, MQ, 2014)		0.4
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
herbicideA substance used to destroy plant pests.
agrochemicalAn agrochemical is a substance that is used in agriculture or horticulture.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (4)

ClassDescription
aromatic etherAny ether in which the oxygen is attached to at least one aryl substituent.
N-sulfonylureaA urea in which one of the hydrogens attached to a nitrogen of the urea group is replaced by a sulfonyl group. The N-sulfonylurea moiety is a key group in various herbicides, as well as in a number of antidiabetic drugs used in the management of type 2 diabetis mellitus.
1,3,5-triazinesAny compound with a 1,3,5-triazine skeleton, in which nitrogen atoms replace carbon at positions 1, 3 and 5 of the core benzene ring structure.
organochlorine compoundAn organochlorine compound is a compound containing at least one carbon-chlorine bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (5)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
RAR-related orphan receptor gammaMus musculus (house mouse)Potency5.41500.006038.004119,952.5996AID1159521
AR proteinHomo sapiens (human)Potency0.15850.000221.22318,912.5098AID588516
estrogen nuclear receptor alphaHomo sapiens (human)Potency25.54480.000229.305416,493.5996AID588513; AID743075
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency5.46050.023723.228263.5986AID743223
thyroid stimulating hormone receptorHomo sapiens (human)Potency68.17130.001628.015177.1139AID1259385
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (72)

Assay IDTitleYearJournalArticle
AID1101201Inhibition of germination of Lepidium sativum at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101012Stimulation of root length of Lactuca sativa cv. Roman (lettuce) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1101212Stimulation of root length of Solanum lycopersicum cv. Tres Cantos (tomato) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101218Stimulation of hypocotyl length of Lactuca sativa cv. Roman (lettuce) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101209Stimulation of root length of Triticum aestivum cv. Cortex (wheat) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101217Stimulation of root length of Lactuca sativa cv. Roman (lettuce) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101206Stimulation of root length of Allium cepa cv. Valenciana (onion) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1100977Inhibition of root length of Lactuca sativa cv. Nigra (lettuce) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1101011Stimulation of germination of Lepidium sativum at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1100986Inhibition of root length of Solanum lycopersicum (tomato) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1101009Stimulation of root length of Lepidium sativum at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1101202Inhibition of hypocotyl length of Lactuca sativa cv. Roman (lettuce) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101013Stimulation of germination of Lactuca sativa cv. Roman (lettuce) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1101214Stimulation of hypocotyl length of Lepidium sativum at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101194Inhibition of hypocotyl length of Triticum aestivum cv. Cortex (wheat) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1100991Inhibition of germination of Triticum aestivum (wheat) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1100992Inhibition of root length of Triticum aestivum (wheat) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1101001Stimulation of germination of Triticum aestivum (wheat) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1101005Stimulation of shoot length of Solanum lycopersicum (tomato) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1100978Inhibition of shoot length of Lactuca sativa cv. Nigra (lettuce) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1101196Inhibition of hypocotyl length of Solanum lycopersicum cv. Tres Cantos (tomato) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1100981Inhibition of shoot length of Lactuca sativa cv. Roman (lettuce) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1101204Inhibition of germination of Lactuca sativa cv. Roman (lettuce) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1100988Inhibition of germination of Allium cepa (onion) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1101213Stimulation of germination of Solanum lycopersicum cv. Tres Cantos (tomato) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1100994Inhibition of germination of Hordeum vulgare (barley) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1100990Inhibition of shoot length of Allium cepa (onion) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1101219Stimulation of germination of Lactuca sativa cv. Roman (lettuce) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101200Inhibition of root length of Lepidium sativum at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1100984Inhibition of shoot length of Lepidium sativum at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1100996Stimulation of shoot length of Hordeum vulgare (barley) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1100999Stimulation of germination of Hordeum vulgare (barley) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1101191Inhibition of hypocotyl length of Allium cepa cv. Valenciana (onion) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101006Stimulation of root length of Solanum lycopersicum (tomato) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1101195Inhibition of germination of Triticum aestivum cv. Cortex (wheat) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1100980Inhibition of root length of Lactuca sativa cv. Roman (lettuce) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1101205Stimulation of hypocotyl length of Allium cepa cv. Valenciana (onion) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101015Stimulation of root length of Lactuca sativa cv. Nigra (lettuce) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1100995Inhibition of root length of Hordeum vulgare (barley) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1101210Stimulation of germination of Triticum aestivum cv. Cortex (wheat) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1100993Inhibition of shoot length of Triticum aestivum (wheat) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1101000Stimulation of root length of Triticum aestivum (wheat) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1101003Stimulation of shoot length of Allium cepa (onion) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1101199Inhibition of germination of Solanum lycopersicum cv. Tres Cantos (tomato) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101215Stimulation of root length of Lepidium sativum at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101197Inhibition of root length of Solanum lycopersicum cv. Tres Cantos (tomato) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101203Inhibition of root length of Lactuca sativa cv. Roman (lettuce) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101002Stimulation of root length of Allium cepa (onion) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1101190Inhibition of root length of Allium cepa cv. Valenciana (onion) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1100987Inhibition of shoot length of Solanum lycopersicum (tomato) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1101198Inhibition of hypocotyl length of Lepidium sativum at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101193Inhibition of root length of Triticum aestivum cv. Cortex (wheat) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1100983Inhibition of root length of Lepidium sativum at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1100976Inhibition of germination of Lactuca sativa cv. Nigra (lettuce) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1100979Inhibition of germination of Lactuca sativa cv. Roman (lettuce) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1101192Inhibition of germination of Allium cepa cv. Valenciana (onion) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1100975Inhibition of shoot length of Hordeum vulgare (barley) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1101014Stimulation of shoot length of Lactuca sativa cv. Nigra (lettuce) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1100985Inhibition of germination of Solanum lycopersicum (tomato) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1100997Stimulation of root length of Hordeum vulgare (barley) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1101007Stimulation of germination of Solanum lycopersicum (tomato) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1101016Stimulation of germination of Lactuca sativa cv. Nigra (lettuce) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1100998Stimulation of shoot length of Triticum aestivum (wheat) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1100982Inhibition of germination of Lepidium sativum at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1101004Stimulation of germination of Allium cepa (onion) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1101208Stimulation of germination of Allium cepa cv. Valenciana (onion) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101207Stimulation of hypocotyl length of Triticum aestivum cv. Cortex (wheat) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101008Stimulation of shoot length of Lepidium sativum at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1101010Stimulation of shoot length of Lactuca sativa cv. Roman (lettuce) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
AID1101216Stimulation of germination of Lepidium sativum at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101211Stimulation of hypocotyl length of Solanum lycopersicum cv. Tres Cantos (tomato) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1100989Inhibition of root length of Allium cepa (onion) at 0.1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7
Natural and synthetic podolactones with potential use as natural herbicide models.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (24)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's5 (20.83)18.2507
2000's16 (66.67)29.6817
2010's2 (8.33)24.3611
2020's1 (4.17)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 35.92

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index35.92 (24.57)
Research Supply Index3.33 (2.92)
Research Growth Index4.62 (4.65)
Search Engine Demand Index48.73 (26.88)
Search Engine Supply Index2.07 (0.95)

This Compound (35.92)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies1 (3.70%)4.05%
Observational0 (0.00%)0.25%
Other26 (96.30%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
bromide
Bromides: Salts of hydrobromic acid, HBr, with the bromine atom in the 1- oxidation state. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)		2.0210halide anion;
monoatomic bromine
carbamates
[no description available]		2.4620amino-acid anion
bentazone
bentazone: RN given refers to parent cpd; structure. bentazone : A benzothiadiazine that is 1H-2,1,3-benzothiadiazin-4(3H)-one 2,2-dioxide substituted by an isopropyl group at position 3.		2.0410benzothiadiazineenvironmental contaminant;
herbicide;
xenobiotic
chlorpyrifos
Chlorpyrifos: An organothiophosphate cholinesterase inhibitor that is used as an insecticide and as an acaricide.. chlorpyrifos : An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.		2.0110chloropyridine;
organic thiophosphate		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
environmental contaminant;
insecticide;
xenobiotic
1,8-naphthalenedicarboxylic acid anhydride
1,8-naphthalenedicarboxylic acid anhydride: used as seed protector from herbicides		1.9810cyclic dicarboxylic anhydride
terbutryne
terbutryn : A methylthio-1,3,5-triazine that is 2-(methylsulfanyl)-1,3,5-triazine substituted by a tert-butylamino and an ethylamino group at positions 2 and 4 respectively.		2.420diamino-1,3,5-triazine;
methylthio-1,3,5-triazine		environmental contaminant;
herbicide;
xenobiotic
phenmedipham
phenmedipham: minor descriptor (72-84); on-line search CARBAMATES (72-84); Index Medicus search HERBICIDES, CARBAMATE (75-84), CARBAMATES (72-75). phenmedipham : A carbamate ester that is (3-methylphenyl)carbamic acid in which the hydrogen of the hydroxy group has been replaced by a 3-[(methoxycarbonyl)amino]phenyl group.		2.0110carbamate esterenvironmental contaminant;
herbicide;
xenobiotic
chlortoluron
chlorotoluron : A member of the class of phenylureas that is urea in which one of the nitrogens is substituted by two methyl groups while the other is substituted by a 3-chloro-4-methylphenyl group. A herbicide that is non-toxic to honeybees but moderately toxic to mammals, birds, earthworms and most aquatic organisms.		2.9240monochlorobenzenes;
phenylureas		agrochemical;
environmental contaminant;
herbicide;
xenobiotic
isoproturon
isoproturon : A member of the class of phenylureas that is 1,1-dimethylurea substituted by a p-cumenyl group at position 3. A selective, systemic herbicide used to control annual grasses and broadleaf weeds in cereals, its use within the EU has been banned after September 2017 on the grounds of potential groundwater contamination and risks to aquatic life; there have also been concerns about its endocrine-disrupting properties.		2.71303-(3,4-substituted-phenyl)-1,1-dimethylureaagrochemical;
environmental contaminant;
herbicide;
xenobiotic
pendimethalin
pendimethalin : A member of the class of substituted anilines that is N-(pentan-3-yl)aniline bearing two additional nitro substituents at positions 2 and 6 as well as two methyl substituents at positions 3 and 4. A herbicide used to control most annual grasses and many annual broad-leaved weeds.		2.0110C-nitro compound;
secondary amino compound;
substituted aniline		agrochemical;
environmental contaminant;
herbicide
permethrin
hemoglobin Atlanta-Coventry: Leu replaced by Pro at beta75 and Leu deleted at beta141		2.0110cyclopropanecarboxylate ester;
cyclopropanes		agrochemical;
ectoparasiticide;
pyrethroid ester acaricide;
pyrethroid ester insecticide;
scabicide
chlorsulfuron
chlorsulfuron: RN given refers to parent cpd; structure given in first source. chlorsulfuron : An N-sulfonylurea that is N-carbamoyl-2-chlorobenzenesulfonamide in which one of the hydrogens attached to the non-sulfonylated nitrogen has been replaced by a 4-methoxy-6-methyl-1,3,5-triazin-2-yl group. A herbicide used for the control of broadleaf weeds in wheat, barley and oats.		2.0110methoxy-1,3,5-triazine;
monochlorobenzenes;
N-sulfonylurea		agrochemical;
EC 2.2.1.6 (acetolactate synthase) inhibitor;
herbicide
metsulfuron methyl
metsulfuron methyl : A N-sulfonylurea in which the sulfonyl group is attached to a 2-(methoxycarbonyl)phenyl group while a (4-methoxy-6-methyl-1,3,5-triazin-2-yl group replaces one of the amino hydrogens of the remaining urea group.		2.1101,3,5-triazines;
benzoate ester;
N-sulfonylurea		environmental contaminant;
herbicide;
xenobiotic
imazaquin
imazaquin: RN given refer to parent cpd. imazaquin : A racemate comprising equimolar amounts of (R)- and (S)-imazaquin. It is a pre- and post-emergence herbicide used for the control of grasses and broad-leaved weeds.. 2-[4-methyl-5-oxo-4-(propan-2-yl)-4,5-dihydro-1H-imidazol-2-yl]quinoline-3-carboxylic acid : A quinolinemonocarboxylic acid that is quinoline-3-carboxylic acid which is substituted by a 4-methyl-5-oxo-4-(propan-2-yl)-4,5-dihydro-1H-imidazol-2-yl group at position 2.		2.0110imidazolone;
monocarboxylic acid;
quinolinemonocarboxylic acid
methyl bensulfuron
methyl bensulfuron: RN given refers to parent cpds. bensulfuron-methyl : The methyl ester of bensulfuron. An acetolactate synthase inhibitor, it is used as a herbicide for the control of a variety of both annual and perennial weeds in crops, particularly wheat and rice. It is not licensed for use within the UK.		2.0110aromatic ether;
methyl ester;
N-sulfonylurea;
pyrimidines		agrochemical;
EC 2.2.1.6 (acetolactate synthase) inhibitor;
herbicide
prosulfocarb
prosulfocarb : A monothiocarbamic ester that is carbamothioic S-acid substituted by two propyl groups at the nitrogen atom and a benzyl group at the the sulfur atom.		7.1710benzenes;
monothiocarbamic ester		environmental contaminant;
herbicide;
xenobiotic
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		2.45201,2,3-triazole
zaluzanin C
zaluzanin C: from Ainsliaea yunnanensis and Zaluzania robinsonii; structure in first source. zaluzanin C : A sesquiterpene lactone that is decahydroazuleno[4,5-b]furan-2(3H)-one substituted by methylidene groups at positions 3, 6 and 9 and a hydroxy group at position 8.		210gamma-lactone;
guaiane sesquiterpenoid;
organic heterotricyclic compound;
secondary alcohol;
sesquiterpene lactone		EC 1.14.13.39 (nitric oxide synthase) inhibitor;
metabolite
dehydrocostus lactone
dehydrocostus lactone : An organic heterotricyclic compound and guaianolide sesquiterpene lactone that is acrylic acid which is substituted at position 2 by a 4-hydroxy-3,8-bis(methylene)decahydoazulen-5-yl group and in which the hydroxy group and the carboxy group have undergone formal condensation to afford the corresponding gamma-lactone.		210gamma-lactone;
guaiane sesquiterpenoid;
organic heterotricyclic compound;
sesquiterpene lactone		antimycobacterial drug;
antineoplastic agent;
apoptosis inducer;
cyclooxygenase 2 inhibitor;
metabolite;
trypanocidal drug
difenoconazole
difenoconazole : A member of the class of dioxolanes that is 1,3-dioxolane substituted at position 2 by 2-chloro-4-(4-chlorophenoxy)phenyl and 1,2,4-triazol-1-ylmethyl groups. A broad spectrum fungicide with novel broad-range activity used as a spray or seed treatment. It is moderately toxic to humans, mammals, birds and most aquatic organisms.		2.0110aromatic ether;
conazole fungicide;
cyclic ketal;
dioxolane;
triazole fungicide;
triazoles		antifungal agrochemical;
EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor;
environmental contaminant;
xenobiotic
halosulfuron methyl
halosulfuron methyl: an herbicide; structure in first source		2.110pyrazoles
ll-z 1271alpha
LL-Z 1271alpha: C(16) terpenoid lactone metabolite from Acrostalagmus; structure		210
ConditionIndicatedRelationship StrengthStudiesTrials
Abnormalities, Autosome
[description not available]		02.0310
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		01.9810