triazoles has been researched along with indazoles in 46 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (10.87) | 18.2507 |
| 2000's | 11 (23.91) | 29.6817 |
| 2010's | 22 (47.83) | 24.3611 |
| 2020's | 8 (17.39) | 2.80 |
| Authors | Studies |
|---|---|
| Otvös, L; Sági, G; Szũcs, K; Vereb, G | 1 |
| Atienza, J; Claramunt, RM; Elguero, J; Escario, JA; Gómez Barrio, A; Mester, B | 1 |
| Durham, SK; Selig, WM; Tocker, JE; Welton, AF | 1 |
| Berend, N; Matheson, MJ; McClean, MA; Rynell, AC | 1 |
| Tachibana, H | 1 |
| Carrupt, PA; Crivori, P; Gnerre, C; Grandi, T; Sparatore, F; Testa, B | 1 |
| Alcaraz, MJ; Aller, E; Fernández, P; Guillén, MI; López-Cremades, P; Lorenzo, A; Molina, P; Ubeda, A | 1 |
| Konovalova, NP | 1 |
| DiJulio, DH; Jacobson, KL; Singh, JC; Watson, EL | 1 |
| Cwiklicki, A; Rehse, K | 1 |
| Alcaraz, MJ; Aller, E; Fernández, P; Gomar, F; Guillén, MI; Molina, P | 1 |
| Arion, VB; Eichinger, A; Guedes da Silva, MF; Keppler, BK; Kukushkin, VY; Lichtenecker, R; Pombeiro, AJ; Reisner, E | 1 |
| Kang, TH; Kim, S; Park, JS; Suh, YG; Yu, KA | 1 |
| Bain, J; Cozza, G; Di Maira, G; Elliott, M; Kazimierczuk, Z; Meggio, F; Orzeszko, A; Pagano, MA; Pinna, LA; Ruzzene, M; Sarno, S | 1 |
| Laleu, B; Lautens, M | 1 |
| Bovens, S; Elfringhoff, AS; Kaptur, M; Lehr, M | 1 |
| Conrad, WE; Fukazawa, R; Haddadin, MJ; Kurth, MJ | 1 |
| De Moor, O; Dorgan, CR; Johnson, PD; Lambert, AG; Lecci, C; Maillol, C; Nugent, G; Poignant, SD; Price, PD; Pye, RJ; Storer, R; Tinsley, JM; Vickers, R; Well, Rv; Wilkes, FJ; Wilson, FX; Wren, SP; Wynne, GM | 1 |
| Castillo, R; López-Vallejo, F; Medina-Franco, JL; Yépez-Mulia, L | 1 |
| Anthony, N; Distefano, D; Felock, P; Flynn, J; Gomez, R; Jolly, SJ; Lai, MT; Liang, Y; McGaughey, G; Miller, M; Munshi, V; Paton, B; Reid, J; Sanchez, R; Torrent, M; Vacca, JP; Wan, BL; Williams, T; Yan, Y | 1 |
| Fozooni, S; Hamidian, H; Hassankhani, A; Mohammadi, SZ | 1 |
| Conrad, WE; Fettinger, JC; Haddadin, MJ; Kurth, MJ; Nguyen, HH; Rodriguez, KX | 1 |
| Chrysikos, D; Dimopoulos, MA; Papadimitriou, CA; Psaltopoulou, T; Sergentanis, TN; Zagouri, F | 1 |
| Chevallier, F; Dorcet, V; Halauko, YS; Ivashkevich, OA; Matulis, VE; Mongin, F; Nagaradja, E; Roisnel, T | 1 |
| Aguilar, H; Balart, J; Barril, X; Beijersbergen, RL; Bonifaci, N; Bostner, J; Brunet, J; Burnstein, KL; Bustelo, XR; Caizzi, L; Carlson, KE; Clarke, R; Climent, F; Di Croce, L; Esteller, M; Extremera, AI; Figueras, A; Fornander, T; García, N; Garcia-Mata, R; Gil, M; Gómez-Baldó, L; Halonen, P; Islam, A; Jansen, MP; Karlsson, E; Katzenellenbogen, JA; Kiyotani, K; Martrat, G; Mushiroda, T; Nakamura, Y; Nevedomskaya, E; Pérez Tenorio, G; Pujana, MA; Rodríguez-Peña, AB; Rodríguez-Vida, A; Serra-Musach, J; Sgroi, DC; Soler, MT; Stål, O; Urruticoechea, A; Villanueva, A; Vizoso, M; Zembutsu, H; Zwart, W | 1 |
| Bao, J; Li, J; Li, X; Luo, K; Wu, C; Zhang, W; Zhou, N | 1 |
| Bagchi, MK; Chen, Y; Gong, P; Katzenellenbogen, BS; Katzenellenbogen, JA; Ko, C; Korach, KS; Nettles, KW; Nwachukwu, JC; Srinivasan, S; Taylor, RN; Zhao, Y | 1 |
| Buijsman, RC; de Man, J; de Roos, JA; de Vetter, JR; Prinsen, MB; Spijkers-Hagelstein, JA; Uitdehaag, JC; van Doornmalen, AM; Zaman, GJ | 1 |
| Baculi, F; Bates, RJ; Bennett, B; Blease, K; Brown, H; Burnett, K; Celeridad, M; Chamberlain, P; Delgado, M; Ferguson, GD; Haelewyn, J; Hickman, M; Jackson, P; Jensen-Pergakes, K; LeBrun, L; Miyazawa, K; Nadolny, L; Nguyen, T; Packard, G; Pagarigan, B; Pierce, S; Plantevin-Krenitsky, V; Tang, Y; Tehrani, L; Torres, S; Xie, W; Xu, L | 1 |
| Bundred, N; Butler, H; Derynck, M; Earl, G; Gazinska, P; Gendreau, S; Hadad, S; Hu, J; Korbie, D; Lackner, MR; Lim, L; Macaskill, J; Mainwaring, P; Parker, P; Pinder, SE; Price, R; Purushotham, A; Sarker, SJ; Schmid, P; Shia, A; Thompson, A; Trau, M; Wheatley, D; Wilson, TR; Woodman, N; Zammit, C | 1 |
| Cao, Y; Deng, M; Ding, ZB; Duan, M; Fan, J; Gao, Q; Liang, CM; Lin, YH; Liu, LZ; Niu, G; Shi, JY; Shi, YY; Wang, XY; Wang, ZC; Worthley, DL; Xi, R; Xia, Y; Xiong, L; Yang, LX; Zhang, S; Zhou, J; Zhou, XY | 1 |
| Carey, LM; Franzen, S; Ghiladi, RA; Hough, MA; McCombs, NL; Moreno-Chicano, T | 1 |
| Dong, W; Liang, J; Qi, J; Yu, P; Zhang, T; Zhu, C | 1 |
| Adjei, AA; Bishop, WR; Carr, D; Chun, P; Cooper, A; Dayananth, P; Deng, Y; Flaherty, KT; Fong, PC; Hwu, WJ; Kirschmeier, P; Long, BJ; Miselis, NR; Moreno, BH; Moschos, SJ; Ramanathan, RK; Ribas, A; Robert, L; Rubin, EH; Rubino, J; Rush, TS; Samatar, AA; Schiller, J; Shapira-Frommer, R; Shipps, GW; Sullivan, RJ; Tawbi, HA; Zhang, D | 1 |
| Alexe, G; Bandopadhayay, P; Beroukhim, R; Cheff, DM; Chen, L; Conway, A; Davis, MI; Goodale, A; Guha, R; Hall, MD; Iniguez, AB; Johannessen, C; Kitara, S; Lee, Y; Menard, M; Nasholm, N; Pantel, S; Patel, S; Piccioni, F; Qi, J; Robichaud, AL; Roti, G; Stegmaier, K; Stolte, B; Wang, EJ; Weiss, WA | 1 |
| Gong, J; Jiang, Z; Yang, T; Zhu, Y | 1 |
| Chen, X; Dai, R; Gao, L; He, F; Hu, L; Kang, D; Liu, J; Wang, J; Wen, Y; Zhou, J | 1 |
| Alexandre, PA; Cordeiro, YG; Fukumasu, H; Müller, S; Pires, PRL; Saranholi, BH; Silva, ER; Xavier, PLP | 1 |
| Mofatehnia, P; Mohajer, F; Moradi, R; Ziarani, GM | 1 |
| Bugide, S; Green, MR; Gupta, R; Wajapeyee, N | 1 |
| Bomsztyk, K; Goryca, K; Kopczynski, M; Kulecka, M; Majewska, E; Masiejczyk, M; Mikula, M; Ostrowski, J; Pysniak, K; Pyziak, K; Rumienczyk, I; Rzymski, T; Sandowska-Markiewicz, Z; Statkiewicz, M; Wojcik-Jaszczynska, K; Wojcik-Trechcinska, U | 1 |
| Ampomah-Wireko, M; Cao, Y; Obaid Arhema Frejat, F; Wang, H; Wu, C; Wu, G; Yang, P; Yang, Y; Yuan, Q; Zhai, H; Zhang, S | 1 |
| Adachi, E; Chong, Z; Diamond, MS; Douek, DC; Duong, C; Fujisaki, S; Furusawa, Y; Godbole, S; Gordon, A; Hagihara, M; Halfmann, PJ; Hasegawa, H; Hattori, SI; Hojo, M; Iida, S; Imai, M; Ito, M; Iwatsuki-Horimoto, K; Kawaoka, Y; Kiso, M; Koga, M; Kuroda, M; Larson, D; Li, R; Liu, Y; Loeber, S; Maeda, K; Maemura, T; Mitamura, K; Mitsuya, H; Murakami, J; Ohmagari, N; Okuda, M; Ozono, S; Saito, M; Sakai-Tagawa, Y; Sato, T; Suzuki, T; Takashita, E; Tsutsumi, T; Ueki, H; Ujie, M; Uraki, R; Valdez, R; Wang, Z; Watanabe, S; Wright, R; Yamamoto, S; Yamayoshi, S; Yasuhara, A; Yotsuyanagi, H | 1 |
| Jiang, N; Liu, S; Tan, Z; Wang, F; Wang, X; Yang, J; Zhai, X; Zhang, J | 1 |
| Bouissane, L; Catto, M; Eddahmi, M; Hafid, A; Khouili, M; La Spada, G | 1 |
| Fukuhara, T; Kubota, R; Kuwata, A; Matsuo, Y; Matsuzaki, T; Shimizu, R; Sonoyama, T | 1 |
1 review(s) available for triazoles and indazoles
| Article | Year |
|---|---|
Hsp90 inhibitors in breast cancer: a systematic review.
Topics: Adenine; Antineoplastic Agents; Benzamides; Benzoquinones; Biomarkers, Tumor; Female; Glycine; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Indazoles; Isoxazoles; Lactams, Macrocyclic; Pyridines; Resorcinols; Triazoles; Triple Negative Breast Neoplasms | 2013 |
3 trial(s) available for triazoles and indazoles
| Article | Year |
|---|---|
Phase II Randomized Preoperative Window-of-Opportunity Study of the PI3K Inhibitor Pictilisib Plus Anastrozole Compared With Anastrozole Alone in Patients With Estrogen Receptor-Positive Breast Cancer.
Topics: Aged; Aged, 80 and over; Anastrozole; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Combined Modality Therapy; Drug Synergism; Female; Humans; Indazoles; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Phosphoinositide-3 Kinase Inhibitors; Postmenopause; Preoperative Care; Protein Kinase Inhibitors; Receptor, ErbB-2; Receptors, Estrogen; Sulfonamides; Triazoles | 2016 |
Development of MK-8353, an orally administered ERK1/2 inhibitor, in patients with advanced solid tumors.
Topics: Administration, Oral; Adult; Animals; Biological Availability; Cell Line, Tumor; Diarrhea; Dogs; Dose-Response Relationship, Drug; Drug Eruptions; Drug Evaluation, Preclinical; Fatigue; Female; Humans; Indazoles; Male; MAP Kinase Signaling System; Maximum Tolerated Dose; Mice; Middle Aged; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nausea; Neoplasm Staging; Neoplasms; Protein Kinase Inhibitors; Pyridines; Pyrrolidines; Rats; Triazoles; Xenograft Model Antitumor Assays; Young Adult | 2018 |
Evaluation of the Drug-Drug Interaction Potential of Ensitrelvir Fumaric Acid with Cytochrome P450 3A Substrates in Healthy Japanese Adults.
Topics: Adult; Area Under Curve; COVID-19; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dexamethasone; Drug Interactions; East Asian People; Humans; Indazoles; Midazolam; Prednisolone; SARS-CoV-2; Triazines; Triazoles | 2023 |
42 other study(ies) available for triazoles and indazoles
| Article | Year |
|---|---|
Synthesis and enzymatic activity of some new purine ring system analogues of adenosine 3',5'-cyclic monophosphate.
Topics: Animals; Benzimidazoles; Cattle; Cyclic AMP; Enzyme Activation; Indazoles; Molecular Structure; Muscles; Myocardium; Phosphorylation; Protein Kinases; Rabbits; Ribose; Spectrum Analysis; Structure-Activity Relationship; Triazoles | 1992 |
Research for new antichagasic drugs.
Topics: Animals; Azoles; Benzimidazoles; Chagas Disease; Imidazoles; Indazoles; Indoles; Mice; Nifurtimox; Nitro Compounds; Thiophenes; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 1991 |
Phospholipase A2-induced pulmonary and hemodynamic responses in the guinea pig. Effects of enzyme inhibitors and mediators antagonists.
Topics: Animals; Azepines; Blood Pressure; Bronchi; Bronchoalveolar Lavage Fluid; Dexamethasone; Enzyme Inhibitors; Guinea Pigs; Humans; Indazoles; Indomethacin; Lung; Male; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Pressure; Propranolol; Pyrilamine; SRS-A; Trachea; Triazoles | 1990 |
Role of platelet activating factor, leukotrienes and polymorphs in the FMLP induced increase in microvascular leakage in rabbit trachea.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alkylating Agents; Animals; Azepines; Bronchitis; Capillary Permeability; Coloring Agents; Disease Models, Animal; Drug Interactions; Evans Blue; Indazoles; Leukotrienes; Male; Mechlorethamine; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Rabbits; Reference Values; Trachea; Triazoles; Vasoconstrictor Agents | 1997 |
[The role of lipid mediators in bronchial hyperresponsiveness and airway eosinophil accumulation induced by antigen challenge in guinea pigs].
Topics: Animals; Azepines; Bridged Bicyclo Compounds; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Eosinophils; Fatty Acids, Monounsaturated; Guinea Pigs; Indazoles; Leukotriene Antagonists; Male; Membrane Proteins; Platelet Membrane Glycoproteins; Prostaglandin Antagonists; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Leukotriene; Receptors, Thromboxane; Triazoles | 2000 |
Monoamine oxidase inhibitor properties of some benzazoles: structure-activity relationships.
Topics: Animals; Benzimidazoles; Drug Evaluation, Preclinical; In Vitro Techniques; Indazoles; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rats; Structure-Activity Relationship; Triazoles | 1999 |
A novel indazolo-triazolo-benzotriazepine exerts anti-inflammatory effects by inhibition of cyclooxygenase-2 activity and nitric oxide synthase-2 expression.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azepines; Blood Platelets; Blotting, Western; Carrageenan; Cell Survival; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Edema; Electrophoretic Mobility Shift Assay; Female; Humans; Indazoles; Isoenzymes; Macrophages; Membrane Proteins; Mice; Microsomes; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Prostaglandin-Endoperoxide Synthases; Triazoles | 2003 |
Ultralow doses of various drugs in chemotherapy of experimental tumors.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Indazoles; Leukemia P388; Lung Neoplasms; Melanoma; Mice; Mitomycin; Neoplasm Metastasis; Neoplasms, Experimental; Triazoles; Xenograft Model Antitumor Assays | 2003 |
Arachidonic acid regulates two Ca2+ entry pathways via nitric oxide.
Topics: Animals; Arachidonic Acid; Calcium; Calcium Signaling; Cells, Cultured; Cyclic GMP; Enzyme Inhibitors; Fura-2; Gadolinium; Indazoles; Mice; Nitric Oxide; Parotid Gland; Ryanodine; Tetracaine; Thapsigargin; Triazoles | 2004 |
Antiaggregating and antithrombotic activities of new 1, 2, 3-triazolecarboxamides.
Topics: Animals; Fibrinolytic Agents; Guanylate Cyclase; Indazoles; Lasers; Phosphoric Diester Hydrolases; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombosis; Triazoles | 2004 |
A novel cyclo-oxygenase-2 inhibitor modulates catabolic and antiinflammatory mediators in osteoarthritis.
Topics: Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Azepines; Cartilage; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Humans; Indazoles; Isoenzymes; Male; Membrane Proteins; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Triazoles | 2004 |
Tuning of redox potentials for the design of ruthenium anticancer drugs -- an electrochemical study of [trans-RuCl(4)L(DMSO)](-) and [trans-RuCl(4)L(2)](-) complexes, where L = imidazole, 1,2,4-triazole, indazole.
Topics: Antineoplastic Agents; Dimethyl Sulfoxide; Drug Design; Electrochemistry; Imidazoles; Indazoles; Molecular Conformation; Molecular Structure; Organometallic Compounds; Oxidation-Reduction; Ruthenium; Stereoisomerism; Triazoles | 2004 |
Discovery of novel indazole-linked triazoles as antifungal agents.
Topics: Administration, Oral; Animals; Antifungal Agents; Aspergillus; Candida; Disease Models, Animal; Indazoles; Mice; Microbial Sensitivity Tests; Rats; Stereoisomerism; Triazoles | 2007 |
The selectivity of inhibitors of protein kinase CK2: an update.
Topics: Animals; Benzimidazoles; Casein Kinase II; Humans; Indazoles; Jurkat Cells; Kinetics; Models, Molecular; Protein Kinase Inhibitors; Rats; Structure-Activity Relationship; Triazoles | 2008 |
Synthesis of annulated 2H-indazoles and 1,2,3- and 1,2,4-triazoles via a one-pot palladium-catalyzed alkylation/direct arylation reaction.
Topics: Alkylation; Catalysis; Indazoles; Palladium; Triazoles | 2008 |
1-(5-Carboxyindol-1-yl)propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha: synthesis and properties of bioisosteric benzimidazole, benzotriazole and indazole analogues.
Topics: Benzimidazoles; Cytosol; Group IV Phospholipases A2; Humans; Indazoles; Indoles; Propionates; Stereoisomerism; Triazoles | 2009 |
The Davis-Beirut reaction: N1,N2-disubstituted-1H-indazolones via 1,6-electrophilic addition to 3-alkoxy-2H-indazoles.
Topics: Combinatorial Chemistry Techniques; Indazoles; Molecular Structure; Triazoles | 2011 |
Discovery and SAR of 2-arylbenzotriazoles and 2-arylindazoles as potential treatments for Duchenne muscular dystrophy.
Topics: Dose-Response Relationship, Drug; Drug Discovery; Humans; Indazoles; Microsomes, Liver; Molecular Structure; Muscular Dystrophy, Duchenne; Solubility; Stereoisomerism; Structure-Activity Relationship; Triazoles | 2011 |
Benzotriazoles and indazoles are scaffolds with biological activity against Entamoeba histolytica.
Topics: Amebicides; Benzimidazoles; Databases, Factual; Entamoeba histolytica; Entamoebiasis; Humans; Indazoles; Inhibitory Concentration 50; Metronidazole; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Structure-Activity Relationship; Triazoles | 2011 |
Design and synthesis of conformationally constrained inhibitors of non-nucleoside reverse transcriptase.
Topics: Animals; Anti-HIV Agents; Cells, Cultured; Dogs; HIV Reverse Transcriptase; HIV-1; Humans; Imidazoles; Indazoles; Models, Molecular; Molecular Conformation; Mutation; Nitriles; Nitrobenzenes; Pyrazoles; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thermodynamics; Triazoles | 2011 |
One-pot and efficient synthesis of triazolo[1,2-a]indazole-triones via reaction of arylaldehydes with urazole and dimedone catalyzed by silica nanoparticles prepared from rice husk.
Topics: Aldehydes; Catalysis; Cyclohexanones; Indazoles; Microwaves; Molecular Structure; Nanoparticles; Oryza; Silicon Dioxide; Triazoles | 2011 |
A one-pot-three-step route to triazolotriazepinoindazolones from oxazolino-2H-indazoles.
Topics: Alkynes; Catalysis; Cyclization; Hydrocarbons, Brominated; Indazoles; Molecular Structure; Oxazoles; Palladium; Triazoles | 2012 |
Deproto-metallation using a mixed lithium-zinc base and computed CH acidity of 1-aryl 1H-benzotriazoles and 1-aryl 1H-indazoles.
Topics: Indazoles; Lithium; Models, Molecular; Organometallic Compounds; Quantum Theory; Triazoles; Zinc | 2014 |
VAV3 mediates resistance to breast cancer endocrine therapy.
Topics: Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers, Tumor; Breast; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Enzyme Activators; ErbB Receptors; Erlotinib Hydrochloride; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Genetic Association Studies; Genetic Variation; Humans; Indazoles; Letrozole; MCF-7 Cells; Nitriles; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-vav; Quinazolines; RNA Interference; RNA, Small Interfering; Tamoxifen; Toremifene; Triazoles | 2014 |
In silico discovery of potential VEGFR-2 inhibitors from natural derivatives for anti-angiogenesis therapy.
Topics: Angiogenesis Inhibitors; Axitinib; Binding Sites; Imidazoles; Indazoles; Molecular Docking Simulation; Protein Structure, Tertiary; Quinuclidines; Thermodynamics; Triazoles; Vascular Endothelial Growth Factor Receptor-2 | 2014 |
Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis.
Topics: Animals; Anti-Inflammatory Agents; Cell Survival; Cells, Cultured; Disease Models, Animal; Disease Progression; Drug Therapy, Combination; Embryonic Stem Cells; Endometriosis; Estrogens; Female; Fertility; Humans; Indazoles; Inflammation; Letrozole; Ligands; Macrophages; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Nitriles; Receptors, Estrogen; Stromal Cells; Treatment Outcome; Triazoles | 2015 |
Selective Targeting of CTNBB1-, KRAS- or MYC-Driven Cell Growth by Combinations of Existing Drugs.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aza Compounds; Benzimidazoles; beta Catenin; Cell Line, Tumor; Cell Proliferation; Humans; Imidazoles; Indazoles; Indoles; Melanoma; Molecular Targeted Therapy; Mutation; Oxazoles; Oximes; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins p21(ras); Pyridones; Pyrimidinones; Quinolines; Sulfonamides; Triazoles; Vemurafenib | 2015 |
A Novel Triazolopyridine-Based Spleen Tyrosine Kinase Inhibitor That Arrests Joint Inflammation.
Topics: Animals; Arthritis, Experimental; Basophils; Cell Line; Collagen; Crystallography, X-Ray; Dose-Response Relationship, Drug; Edema; Eosinophils; Female; HEK293 Cells; Humans; Hypertension; Indazoles; Inflammation; Inhibitory Concentration 50; Intracellular Signaling Peptides and Proteins; Janus Kinase 2; Male; Neutropenia; Neutrophils; Protein-Tyrosine Kinases; Pyridines; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Receptors, Fc; Skin; Syk Kinase; Triazoles; Vascular Endothelial Growth Factor Receptor-2 | 2016 |
Cell Culture System for Analysis of Genetic Heterogeneity Within Hepatocellular Carcinomas and Response to Pharmacologic Agents.
Topics: Antineoplastic Agents; Azepines; Base Sequence; Carcinoma, Hepatocellular; Cell Line, Tumor; Clonal Evolution; DNA Copy Number Variations; DNA Mutational Analysis; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Exome; Fibroblast Growth Factors; Gene Amplification; Genetic Heterogeneity; Humans; Indazoles; Liver Neoplasms; Mutation, Missense; Pharmacogenomic Variants; Phylogeny; Primary Cell Culture; Receptor, Fibroblast Growth Factor, Type 4; RNA, Messenger; Sequence Deletion; Triazoles | 2017 |
Interaction of Azole-Based Environmental Pollutants with the Coelomic Hemoglobin from Amphitrite ornata: A Molecular Basis for Toxicity.
Topics: Amino Acid Motifs; Animals; Benzimidazoles; Catalytic Domain; Computational Biology; Environmental Pollutants; Enzyme Inhibitors; Fungicides, Industrial; Hemoglobins; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Imidazoles; Indazoles; Isoenzymes; Kinetics; Ligands; Models, Molecular; Peroxidases; Pesticides; Polychaeta; Recombinant Fusion Proteins; Recombinant Proteins; Triazoles | 2017 |
Adrenomedullin serves a role in the humoral pathway of delayed remote ischemic preconditioning via a hypoxia-inducible factor-1α-associated mechanism.
Topics: Adrenomedullin; Animals; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Indazoles; Ischemic Preconditioning; Kidney; Male; Malondialdehyde; Pyrazoles; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase; Triazoles; Up-Regulation | 2018 |
Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling.
Topics: Animals; Azepines; Cell Line, Tumor; Disease-Free Survival; Drug Resistance, Neoplasm; Epigenesis, Genetic; Female; Humans; Indazoles; Mice, Nude; Molecular Targeted Therapy; Neuroblastoma; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proteins; Signal Transduction; Sulfonamides; Triazoles; Xenograft Model Antitumor Assays | 2018 |
In vitro and in vivo pharmacokinetics and metabolism of MK-8353 by liquid chromatography combined with diode array detector and Q-Exactive-Orbitrap tandem mass spectrometry.
Topics: Administration, Intravenous; Administration, Oral; Animals; Biological Availability; Chromatography, Liquid; Dogs; Female; Humans; Indazoles; Male; Protein Kinase Inhibitors; Pyridines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Species Specificity; Tandem Mass Spectrometry; Triazoles | 2019 |
Design, synthesis and biological evaluation of novel 1
Topics: Antineoplastic Agents; Benzothiazoles; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Indazoles; Molecular Docking Simulation; Molecular Structure; Protein Kinase Inhibitors; Receptor, Fibroblast Growth Factor, Type 1; Structure-Activity Relationship; Triazoles | 2020 |
An epigenetic screening determines BET proteins as targets to suppress self-renewal and tumorigenicity in canine mammary cancer cells.
Topics: Animals; Antineoplastic Agents; Azepines; Biomarkers, Tumor; Carcinogenesis; Cell Proliferation; Dog Diseases; Dogs; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genetic Testing; Indazoles; Mammary Neoplasms, Animal; Multigene Family; Neoplastic Stem Cells; Pyridones; Transcription Factors; Triazoles | 2019 |
The Molecular Diversity Scope of Urazole in the Synthesis of Organic Compounds.
Topics: Catalysis; Chemistry Techniques, Synthetic; Indazoles; Organic Chemicals; Pyrazoles; Spiro Compounds; Triazoles | 2019 |
EZH2 inhibits NK cell-mediated antitumor immunity by suppressing CXCL10 expression in an HDAC10-dependent manner.
Topics: Animals; Benzopyrans; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Chemokine CXCL10; Chemokines; Decitabine; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Histone Deacetylases; Humans; Indazoles; Indoles; Killer Cells, Natural; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Phenols; Pyridones; Sulfones; Triazoles | 2021 |
Selective Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibition by the SCH772984 Compound Attenuates In Vitro and In Vivo Inflammatory Responses and Prolongs Survival in Murine Sepsis Models.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Chemokine CCL2; Disease Models, Animal; Down-Regulation; Drug Repositioning; Endotoxemia; Gene Expression Regulation; Indazoles; Lipopolysaccharides; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 3; Piperazines; Platelet Activation; Pyridines; Pyrrolidines; RAW 264.7 Cells; Transcriptome; Triazoles; Tumor Necrosis Factor-alpha | 2021 |
Novel indazole skeleton derivatives containing 1,2,3-triazole as potential anti-prostate cancer drugs.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Indazoles; Male; Molecular Structure; Prostatic Neoplasms; Skeleton; Structure-Activity Relationship; Triazoles | 2022 |
Characterization and antiviral susceptibility of SARS-CoV-2 Omicron BA.2.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Neutralizing; Antibodies, Viral; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Cricetinae; Cytidine; Drug Combinations; Hydroxylamines; Indazoles; Lactams; Leucine; Mice; Nitriles; Proline; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Triazines; Triazoles | 2022 |
Design, synthesis and anti-tumor efficacy of novel phenyl thiazole/triazole derivatives as selective TrkA inhibitors.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Indazoles; Molecular Structure; Morpholinos; Protein Kinase Inhibitors; Structure-Activity Relationship; Thiazoles; Triazoles; Tropomyosin | 2022 |
Towards Alzheimer's disease-related targets: One-pot Cu(I)- mediated synthesis of new nitroindazolyltriazoles.
Topics: Alzheimer Disease; Amyloidogenic Proteins; Brain; Catalysis; Cholinesterases; Copper; Indazoles; Monoamine Oxidase; Triazoles | 2023 |